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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CYLD binds TRAF3.

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TRAF3 binds TRAF5, TRAF6, and CYLD. 1 / 1

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sparser

"After initial details of the negative regulation of NF-kB by CYLD emerged, it was found that TRAF3, TRAF5 and TRAF6 do not interact with CYLD but a TRAF-interacting protein (TRIP) does [ xref , xref ]."

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TRAF3 binds CYLD. 1 / 1

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sparser

"We have previously shown that mutations in CYLD and TRAF3 are associated with non-hyperdiploid karyotypes with a t(4;14)."

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CYLD ubiquitinates TRAF3.

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CYLD leads to the ubiquitination of TRAF3. 1 / 1

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reach

"Other DUBs that target the RIG-I and MDA5 pathway include CYLD and DUBA which target RIG-I and TRAF3 ubiquitination respectively (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...