IndraLab

Statements

CYLD affects TRAF2
9 2 7 1 1 | 47 28
CYLD binds TRAF2.
7 1 | 15 25
TRAF2 binds CYLD. 10 / 38
7 1 | 13 15
biogrid
No evidence text available
23405219
reach
"TNFalpha treatment increases the binding between PrP and the deubiquitinase tumor suppressor cylindromatosis (CYLD), in these treated cells, binding of CYLD to RIP1 and TRAF2 is reduced."
28900035
sparser
"Thus, the loss of HSC dormancy that occurs in these mice is most likely solely caused by an impaired CYLD–TRAF2 interaction."
25824820
reach
"Recently, it was reported that CYLD directly interacts with NEMO and IKKgamma and TRAF2 in the NF-kappaB signaling pathway."
15341735
biogrid
No evidence text available
12917691
biogrid
No evidence text available
12917691
sparser
"This phenotype is dependent on the interactions between CYLD and its substrate TRAF2 (tumor necrosis factor–associated factor 2)."
25824820
reach
"CYLD interacts directly with TRAF2, an adaptor molecule involved in signaling by members of the family of TNF and nerve growth factor receptors."
19489724
biogrid
No evidence text available
12917691
reach
"It was also shown that CYLD, a de-ubiquitinase known to remove K63 linked polyubiquitin chains from other proteins, binds TRAF2 [68]."
26993379
TRAF2 binds CYLD and IKBKG. 3 / 3
| 3
sparser
"Mechanistically, CYLD binds to NEMO and TRAF2 and reverses non-K48-linked polyubiquitination of TRAF2, thereby blocking TRAF2-mediated activation of the IKK complex [ xref - xref ] ( xref )."
27844253
sparser
"The direct interaction of CYLD with both TRAF2 and NEMO is facilitated by N-terminal protein-protein interaction domains and contributes to its activity toward these substrates ( Kovalenko et al., 200[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
sparser
"Interestingly, CYLD interacts with NEMO (IKKγ; references xref – xref ) and TRAF2 ( xref , xref ), both of which are recruited to the TNF receptor upon ligand binding."
14676304
RIPK1 binds TRAF2 and CYLD. 2 / 2
| 2
sparser
"Interactions between CYLD and RIP1 or TRAF2 were specific as isotype controls did not pull down any CYLD ( xref , A and B )."
28900035
sparser
"TNFα treatment increases the binding between PrP and the deubiquitinase tumor suppressor cylindromatosis (CYLD), in these treated cells, binding of CYLD to RIP1 and TRAF2 is reduced."
28900035
RIPK1 binds TRADD, TRAF2, CYLD, and BIRC2. 1 / 1
| 1
sparser
"TNFα activates the TNF receptor, which induces the formation of a complex formed by TRADD, TRAF2, RIPK1, CYLD, and cIAP1 at the cytoplasmic membrane."
35252383
TRAF2 binds CYLD and K63. 1 / 1
| 1
reach
"When CYLD associates with TRAF2, it removes the K63 and M1 poly-ubiquitin chains from RIPK1, thereby allowing RIPK1 to dissociate from the TNFR1 complex."
33324405
TRAF2 binds CYLD, IKBKG, and BCL3. 1 / 1
| 1
sparser
"In addition to these well-defined protein domains, new domains of CYLD have been defined, based on mutational analyses, for the interaction of CYLD with TRAF2, IKKγ and BCL-3 (Refs xref , xref )."
18535581
TNFAIP3 binds TNFRSF9, TRAF2, and CYLD. 1 / 1
| 1
sparser
"The deubiquitinases A20 and CYLD interact with the 4-1BB and TRAF2 complex and, by regulating the ubiquitination of TRAF2 and TAK1 ( xref ), they decrease 4-1BB activation [ xref ]."
| PMC
IKK_complex binds TRAF2, TRAF6, and CYLD. 1 / 1
| 1
sparser
"The initial clue to the signaling function of CYLD came from an RNAi-based functional screening study, which identified CYLD as a DUB that negatively regulates NF- κ B activation. xref At the same time, yeast two-hybrid screening studies identified CYLD as a protein that binds to NF- κ B essential modulator (NEMO), a regulatory subunit of I κ B kinase (IKK). xref , xref CoIP assays also revealed the association of CYLD with two IKK regulatory proteins, TRAF2 and TRAF6, and subsequent studies identified additional molecular targets of CYLD ( xref )."
19373246
NFkappaB binds TRAF2 and CYLD. 1 / 1
| 1
sparser
"Recently, it was reported that CYLD directly interacts with NEMO/IKKgamma and TRAF2 in the NF-kappaB signaling pathway."
15341735
TRAF2 binds mutated CYLD. 1 / 1
| 1
reach
"The biochemical analysis using phosphomimetic mutants demonstrated that this PTM negatively affects the deubiquitinating activity of CYLD on TRAF2, most likely through interfering with the catalytic activity of CYLD, since the binding of TRAF2 to a CYLD mutant mimicking phosphorylation on Ser 418 is not affected."
21480003
CYLD deubiquitinates TRAF2.
1 1 | 19
CYLD deubiquitinates TRAF2. 10 / 18
1 1 | 16
signor
"Cyld also interacts directly with tumour-necrosis factor receptor (tnfr)-associated factor 2 (traf2), an adaptor molecule involved in by members of the family of tnf/nerve growth factor receptors. (articolo-abstract)"
12917691
reach
"Using an shRNA approach, Brummelkamp et al. showed that CYLD inhibits NF-kappaB signaling by counteracting TRAF2 ubiquitination [XREF_BIBR]."
21119682
reach
"The steady state association of TRAF2 with MLKL was diminished upon TNF induced necroptosis induction, and this correlated with CYLD dependent deubiquitylation of TRAF2."
27158445
reach
"Numerous studies in vitro and in vivo have validated that CYLD mediates NF-κB activation by deubiquitinating TRAF2, TRAF6, and NEMO, making it an important regulator in the adaptive immune response."
30285829
reach
"The Cylindroma tumour suppressor protein (CYLD) de-ubiquitinates NEMO and TRAF2 [XREF_BIBR - XREF_BIBR], while USP15 reverses betaTRCP mediated ubiquitination of IkappaBalpha [XREF_BIBR]."
22212761
reach
"Here we described that the adenoviral vector expressing CYLD (Ad/hTERT-CYLD) augmented the cytotoxicity of TRAIL in HCC cells by negatively regulating NF-kappaB activity since CYLD could reverse the ubiquitination of TNF receptor associated factor 2 (TRAF2) and interact with the IkappaB kinasegamma (IKKgamma)."
16627981
reach
"Contributing to the " death signal ", CYLD deubiquitylates TRAF2 and RIPK1, allowing the formation of the ripoptosome."
| PMC
reach
"Another example is already mentioned CYLD, which is an important inflammatory mediator that deubiquitinates TRAF2 and TRAF6, resulting in negative regulation of the NF-kappaB pathway [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23151130
reach
"Because the target of CYLD in the NF-kappaB pathway is known to be deubiquitination of TRAF2, we also confirmed the deubiquitination of TRAF2 by CYLD in ECs."
18245814
ubibrowser
"We conclude that PrP traps CYLD, preventing it from binding and deubiquitinating RIP1 and TRAF2."
28900035
Modified CYLD leads to the deubiquitination of TRAF2. 2 / 2
| 2
reach
"Indeed, immunoprecipitation analysis showed that overexpression of CYLD induced deubiquitination of TRAF2 in ECs."
18245814
reach
"Of importance, overexpression of catalytically inactive CYLD did not induce deubiquitination of TRAF2."
18245814
Mutated CYLD leads to the deubiquitination of TRAF2. 1 / 1
| 1
reach
"When these serines are mutated to alanines, it generates a super-active CYLD mutant that prevents TNF-alpha-stimulated TRAF2 ubiquitination."
19373246
CYLD ubiquitinates TRAF2.
9 | 9 1
CYLD ubiquitinates TRAF2. 9 / 10
| 8 1
reach
"We show that CYLD binds to the NEMO (also known as IKKgamma) component of the IkappaB kinase (IKK) complex, and appears to regulate its activity through de-ubiquitination of TRAF2, as TRAF2 ubiquitination can be modulated by CYLD."
12917690
reach
"CYLD mediated regulation of the JNK signaling pathway appears to target TRAF2 ubiquitylation, as CYLD knockdown increases both TRAF2 ubiquitylation and JNK activation, further enhancing cell survival [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
reach
"CYLD also decreased IFN promotor activation by deubiquitinating TRAF2 and TRAF6 in HEK293T cells, respectively [XREF_BIBR, XREF_BIBR]."
31208841
sparser
"Ubiquitination of TRAF2 by CYLD was found to be nearly abolished in the presence of a dominant negative ubiquitin-specific protease mutant deficient in CYLD ( xref )."
27508514
reach
"A20 also suppresses necroptosis by deubiquitinating RIPK3 at K5, whereas CYLD mediates necroptotic effects by deubiquitinating TNF receptor associated factor 2 (TRAF2)."
27959630
reach
"Ubiquitination of TRAF2 by CYLD was found to be nearly abolished in the presence of a dominant negative ubiquitin specific protease mutant deficient in CYLD."
27508514
reach
"CYLD knockdown by siRNA results in constitutive ubiquitination of TRAF2."
19373246
reach
"CYLD also decreased IFN promotor activation by deubiquitinating TRAF2 and TRAF6 in HEK293 T cells, respectively [29,30]."
31208841
reach
"CYLD can inhibit NF-kappaB activity by deubiquitinating and inactivating TRAF2 and TRAF6, RIP, NEMO, and the NF-kappaB co-activator BCL-3."
18718859
CYLD ubiquitinates TRAF2 on lysine. 9 / 9
9 |
biopax:pid
No evidence text available
16543241
biopax:pid
No evidence text available
8565075
biopax:pid
No evidence text available
10848577
biopax:pid
No evidence text available
12917690
biopax:pid
No evidence text available
9915703
biopax:pid
No evidence text available
12917691
biopax:pid
No evidence text available
8612133
biopax:pid
No evidence text available
12917689
biopax:pid
No evidence text available
16603398
CYLD-S418A leads to the ubiquitination of TRAF2. 1 / 1
| 1
reach
"In constrast, cotransfection of CYLD S418A with IKKepsilon did not block deubiquitination of TRAF2 (XREF_FIG)."
19481526
CYLD inhibits TRAF2.
1 | 2 2
CYLD inhibits TRAF2. 5 / 8
1 | 2 2
reach
"CYLD also inhibits TRAF2 and NEMO (NF-kappaB essential modulator, a regulatory subunit of IKK), and blocks NF-kappaB signaling downstream to TLR activation [176] [177] [178]."
| DOI
signor
"Cyld also interacts directly with tumour-necrosis factor receptor (tnfr)-associated factor 2 (traf2), an adaptor molecule involved in by members of the family of tnf/nerve growth factor receptors. (articolo-abstract)"
12917691
reach
"Similarly, de-ubiquitinating enzyme cylindromatosis (CYLD) inhibits NF-kappaB signaling via de-ubiquitination and inactivation of TNFR associated factor 2 (TRAF2) and TRAF6 [XREF_BIBR, XREF_BIBR]; de-ubiquitinating protease A20 inhibits NF-kappaB activation induced by Toll like receptor 4 (TLR4) via removing K63 linked polyubiquitin chains of TRAF6 [XREF_BIBR]."
27164085
sparser
"Similarly to active-site C601 CYLD mutants ( Trompouki et al. , 2003 ; this work), CYLD-D681G was unable to inhibit TRAF2- or TRAF6-mediated activation of NF- κ B and TNF α activation of JNK, and to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17851586
sparser
"CYLD also inhibits TRAF2 and NEMO (NF-κB essential modulator, a regulatory subunit of IKK), and blocks NF-κB signaling downstream to TLR activation [176] [177] [178] ."
| DOI
CYLD activates TRAF2.
| 2
CYLD activates TRAF2. 2 / 2
| 2
reach
"The regulation of TRAF2 signaling by CYLD was identified by screening an RNAi library targeting DUBs for ones that attenuate NFkappaB activation [XREF_BIBR] and through a two-hybrid screen for proteins that interact with the regulatory subunit of the IkappaB kinase complex that could also bind to TRAF2 [XREF_BIBR]."
19007437
reach
"In contrast to earlier studies, which had shown that CYLD acts as a Lys-63-specific DUB, Xue et al. found that CYLD removes Lys 48 polyubiquitin chains from TRAF2, thereby preventing TRAF2 proteolytic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
TRAF2 affects CYLD
7 1 | 15 26
TRAF2 binds CYLD.
7 1 | 15 25
TRAF2 binds CYLD. 10 / 38
7 1 | 13 15
biogrid
No evidence text available
23405219
reach
"TNFalpha treatment increases the binding between PrP and the deubiquitinase tumor suppressor cylindromatosis (CYLD), in these treated cells, binding of CYLD to RIP1 and TRAF2 is reduced."
28900035
sparser
"Thus, the loss of HSC dormancy that occurs in these mice is most likely solely caused by an impaired CYLD–TRAF2 interaction."
25824820
reach
"Recently, it was reported that CYLD directly interacts with NEMO and IKKgamma and TRAF2 in the NF-kappaB signaling pathway."
15341735
biogrid
No evidence text available
12917691
biogrid
No evidence text available
12917691
sparser
"This phenotype is dependent on the interactions between CYLD and its substrate TRAF2 (tumor necrosis factor–associated factor 2)."
25824820
reach
"CYLD interacts directly with TRAF2, an adaptor molecule involved in signaling by members of the family of TNF and nerve growth factor receptors."
19489724
biogrid
No evidence text available
12917691
reach
"It was also shown that CYLD, a de-ubiquitinase known to remove K63 linked polyubiquitin chains from other proteins, binds TRAF2 [68]."
26993379
TRAF2 binds CYLD and IKBKG. 3 / 3
| 3
sparser
"Mechanistically, CYLD binds to NEMO and TRAF2 and reverses non-K48-linked polyubiquitination of TRAF2, thereby blocking TRAF2-mediated activation of the IKK complex [ xref - xref ] ( xref )."
27844253
sparser
"The direct interaction of CYLD with both TRAF2 and NEMO is facilitated by N-terminal protein-protein interaction domains and contributes to its activity toward these substrates ( Kovalenko et al., 200[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
sparser
"Interestingly, CYLD interacts with NEMO (IKKγ; references xref – xref ) and TRAF2 ( xref , xref ), both of which are recruited to the TNF receptor upon ligand binding."
14676304
RIPK1 binds TRAF2 and CYLD. 2 / 2
| 2
sparser
"Interactions between CYLD and RIP1 or TRAF2 were specific as isotype controls did not pull down any CYLD ( xref , A and B )."
28900035
sparser
"TNFα treatment increases the binding between PrP and the deubiquitinase tumor suppressor cylindromatosis (CYLD), in these treated cells, binding of CYLD to RIP1 and TRAF2 is reduced."
28900035
RIPK1 binds TRADD, TRAF2, CYLD, and BIRC2. 1 / 1
| 1
sparser
"TNFα activates the TNF receptor, which induces the formation of a complex formed by TRADD, TRAF2, RIPK1, CYLD, and cIAP1 at the cytoplasmic membrane."
35252383
TRAF2 binds CYLD and K63. 1 / 1
| 1
reach
"When CYLD associates with TRAF2, it removes the K63 and M1 poly-ubiquitin chains from RIPK1, thereby allowing RIPK1 to dissociate from the TNFR1 complex."
33324405
TRAF2 binds CYLD, IKBKG, and BCL3. 1 / 1
| 1
sparser
"In addition to these well-defined protein domains, new domains of CYLD have been defined, based on mutational analyses, for the interaction of CYLD with TRAF2, IKKγ and BCL-3 (Refs xref , xref )."
18535581
TNFAIP3 binds TNFRSF9, TRAF2, and CYLD. 1 / 1
| 1
sparser
"The deubiquitinases A20 and CYLD interact with the 4-1BB and TRAF2 complex and, by regulating the ubiquitination of TRAF2 and TAK1 ( xref ), they decrease 4-1BB activation [ xref ]."
| PMC
IKK_complex binds TRAF2, TRAF6, and CYLD. 1 / 1
| 1
sparser
"The initial clue to the signaling function of CYLD came from an RNAi-based functional screening study, which identified CYLD as a DUB that negatively regulates NF- κ B activation. xref At the same time, yeast two-hybrid screening studies identified CYLD as a protein that binds to NF- κ B essential modulator (NEMO), a regulatory subunit of I κ B kinase (IKK). xref , xref CoIP assays also revealed the association of CYLD with two IKK regulatory proteins, TRAF2 and TRAF6, and subsequent studies identified additional molecular targets of CYLD ( xref )."
19373246
NFkappaB binds TRAF2 and CYLD. 1 / 1
| 1
sparser
"Recently, it was reported that CYLD directly interacts with NEMO/IKKgamma and TRAF2 in the NF-kappaB signaling pathway."
15341735
TRAF2 binds mutated CYLD. 1 / 1
| 1
reach
"The biochemical analysis using phosphomimetic mutants demonstrated that this PTM negatively affects the deubiquitinating activity of CYLD on TRAF2, most likely through interfering with the catalytic activity of CYLD, since the binding of TRAF2 to a CYLD mutant mimicking phosphorylation on Ser 418 is not affected."
21480003
TRAF2 ubiquitinates CYLD.
| 1
TRAF2 ubiquitinates CYLD. 1 / 1
| 1
sparser
"CYLD-mediated regulation of the JNK signaling pathway appears to target TRAF2 ubiquitylation, as CYLD knockdown increases both TRAF2 ubiquitylation and JNK activation, further enhancing cell survival [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
sparser
"The 21 core genes associated with the RIG-I-like receptor signaling pathway included IFIH1, TRIM25, NFKB1, DHX58, DDX3X, IRF7, ISG15, DDX58, TRAF2, MAPK11, RELA, CXCL8, TBK1, IL12B, RIPK1, NFKBIA, CYLD, IL12A, TNF, AZI2 , and TANK ."
34490145