IndraLab

Statements

BTRC affects USP47
6 1 | 5 11
BTRC binds USP47.
6 | 4 10
BTRC binds USP47. 10 / 25
6 | 4 10
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"For example, USP47 could bind to β-TrCP through its unique “DEGICLE” motif (Shi et al., 2015)."
34604226
sparser
"At the post-translational level, studies have shown that USP47 interacts with β-TrCP proteins in the E3 ubiquitin ligase complex SCF."
34604226
biogrid
No evidence text available
25332235
biogrid
No evidence text available
25900982
biogrid
No evidence text available
28514442
reach
"Moreover, endoplasmic reticulum aminopeptidase 1, a key regulator of innate and adaptive anti-tumor immune responses, was found to interact with USP47 and thus interfered with the interaction of USP47 and β-TrCP, leading to ubiquitination degradation of β-TrCP (Bufalieri et al., 2019)."
34604226
biogrid
No evidence text available
19966869
sparser
"Therefore, FAM83H and SCRIB stabilize β-catenin protein by protecting it from proteasomal degradation via interaction with β-TrCP and USP47."
32564009
sparser
"For example, USP47 could bind to β-TrCP through its unique “ DEG ICL E ” motif ( xref )."
34604226
sparser
"Another study showed that USP47 bound to β-TrCP and mediated its deubiquitination to stabilize its expression ( xref )."
34604226
BTRC ubiquitinates USP47.
1 | 1 1
BTRC leads to the ubiquitination of USP47. 3 / 3
1 | 1 1
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"Furthermore, USP47 deubiquitinates itself, whereas beta-TrCP promotes USP47 ubiquitination through interaction with an atypical motif in USP47."
26169834
ubibrowser
"UbiNet 2.0"
24658274
sparser
"Furthermore, USP47 deubiquitinates itself, whereas β-TrCP promotes USP47 ubiquitination through interaction with an atypical motif in USP47."
26169834
USP47 affects SNAI1
1 | 16 8
USP47 binds SNAI1.
| 8 8
SNAI1 binds USP47. 10 / 14
| 8 6
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"USP47 binds to Snail and triggers its deubiquitination."
29162839
reach
"However, under hypoxic conditions, USP47 binding to Snail was markedly enhanced."
29162839
sparser
"Taken together, these results indicate that USP47 interacts directly with Snail and impedes its ubiquitination and subsequent proteasomal degradation."
29162839
reach
"To visualize the interaction between Snail and USP47, we stained the DLD-1 cells with fluorescent probes detecting USP47 (red) and Snail (green)."
29162839
sparser
"This observation implies that USP47 binds to Snail and removes ubiquitins from it in the cytoplasm of DLD-1 cells."
29162839
reach
"Taken together, these results indicate that USP47 interacts directly with Snail and impedes its ubiquitination and subsequent proteasomal degradation."
29162839
sparser
"Notably, USP47 interacts directly with Snail and enhances its stability."
29162839
sparser
"However, under hypoxic conditions, USP47 binding to Snail was markedly enhanced (Fig.  xref )."
29162839
sparser
"USP47 binds to Snail and triggers its deubiquitination."
29162839
reach
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
SNAI1 binds USP47 and CXXC1. 1 / 1
| 1
sparser
"It would be worthwhile determining whether USP47 can bind to Snail at the SNAG or zinc finger domains and whether such interaction contributes to stabilization of its substarte Snail."
29162839
SATB1 binds SNAI1 and USP47. 1 / 1
| 1
sparser
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
USP47 deubiquitinates SNAI1.
1 | 2
USP47 deubiquitinates SNAI1. 3 / 3
1 | 2
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"USP47 has been shown to induce the decomposition of E-cadherin and promote the epithelial–mesenchymal transition via Snail-deubiquitination (Choi et al., 2017)."
34604226
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"USP47, which deubiquitinates SNAIL1, is upregulated in hypoxia via a transcription factor cascade."
32470488
ubibrowser
"Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9"
29162839
USP47 activates SNAI1.
| 3
USP47 activates SNAI1. 3 / 3
| 3
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"Because hypoxia induced USP47 expression enhanced EMT by stabilizing Snail, we investigated the contribution of USP47 to tumor growth and invasion in vivo."
29162839
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"Silencing of USP47 accelerated the proteasomal degradation of Snail and inhibited EMT."
29162839
reach
"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
34604226
USP47 increases the amount of SNAI1.
| 2
USP47 increases the amount of SNAI1. 2 / 2
| 2
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"We found that the USP47 elevated the protein level of Snail without influencing the expression of its mRNA."
29162839
reach
"Transient knockdown of USP47 in DLD-1 cells lowered the expression of Snail protein."
29162839
USP47 inhibits SNAI1.
| 1
USP47 inhibits ubiquitinated SNAI1. 1 / 1
| 1
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"Silencing of USP47 significantly increased the accumulation of ubiquitinated Snail."
29162839
USP47 affects BTRC
6 | 4 10
BTRC binds USP47. 10 / 25
6 | 4 10
reach
"For example, USP47 could bind to β-TrCP through its unique “DEGICLE” motif (Shi et al., 2015)."
34604226
sparser
"At the post-translational level, studies have shown that USP47 interacts with β-TrCP proteins in the E3 ubiquitin ligase complex SCF."
34604226
biogrid
No evidence text available
25332235
biogrid
No evidence text available
25900982
biogrid
No evidence text available
28514442
reach
"Moreover, endoplasmic reticulum aminopeptidase 1, a key regulator of innate and adaptive anti-tumor immune responses, was found to interact with USP47 and thus interfered with the interaction of USP47 and β-TrCP, leading to ubiquitination degradation of β-TrCP (Bufalieri et al., 2019)."
34604226
biogrid
No evidence text available
19966869
sparser
"Therefore, FAM83H and SCRIB stabilize β-catenin protein by protecting it from proteasomal degradation via interaction with β-TrCP and USP47."
32564009
sparser
"For example, USP47 could bind to β-TrCP through its unique “ DEG ICL E ” motif ( xref )."
34604226
sparser
"Another study showed that USP47 bound to β-TrCP and mediated its deubiquitination to stabilize its expression ( xref )."
34604226
USP47 affects CDH1
1 | 16 1
USP47 deubiquitinates CDH1.
1 | 4
USP47 deubiquitinates CDH1. 5 / 5
1 | 4
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"As mentioned above, E-cadherin is deubiquitinated by USP47."
34604226
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"USP47 can be recruited to AJs and suppress the ubiquitination of E-cadherin, thus inhibiting its resultant proteasomal degradation."
29080116
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"However, as mentioned above, E-cadherin can also be deubiquitinated and stabilized by USP47."
34604226
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
ubibrowser
"USP47 can be recruited to AJs and suppress the ubiquitination of E-cadherin, thus inhibiting its resultant proteasomal degradation"
29080116
USP47 activates CDH1.
| 5
USP47 activates CDH1. 5 / 5
| 5
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"The enhancement of USP47 in colorectal cancer cells under hypoxic conditions induced the disassembly of E-cadherin and promoted EMT through deubiquitination of Snail."
29162839
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"Therefore, the modulation of E-cadherin by USP47 may be related to the cell states."
34604226
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"KIFC3 and USP47 depletion enhances formation of a unique E-cadherin fragment."
25253721
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"Depletion of KIFC3 or USP47 promotes cleavage of E-cadherin at a juxtamembrane region of the cytoplasmic domain, resulting in the production of a 90-kDa fragment and the internalization of E-cadherin."
25253721
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
34604226
USP47 decreases the amount of CDH1.
| 4
USP47 decreases the amount of CDH1. 2 / 2
| 2
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"Knockdown of USP47 suppressed the expression of vimentin and N-cadherin and restored E-cadherin expression under hypoxic conditions."
29162839
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"Besides, USP47 knockout could increase E-cadherin expression and inhibited β-catenin expression in HCT116 cells, which is the reverse process of EMT."
34604226
USP47 bound to SNAI1 decreases the amount of CDH1. 1 / 1
| 1
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"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
USP47 bound to SATB1 decreases the amount of CDH1. 1 / 1
| 1
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"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
USP47 binds CDH1.
| 1 1
CDH1 binds USP47. 2 / 2
| 1 1
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"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
sparser
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
USP47 ubiquitinates CDH1.
| 1
USP47 leads to the ubiquitination of CDH1. 1 / 1
| 1
reach
"Enhancement of E-cadherin ubiquitination by KIFC3 and USP47 depletion."
25253721
USP47 increases the amount of CDH1.
| 1
USP47 increases the amount of CDH1. 1 / 1
| 1
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"Knockdown of USP47 suppressed the expression of vimentin and N-cadherin and restored E-cadherin expression under hypoxic conditions."
29162839
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"For example, USP47 overexpression accelerated ovarian cancer cell development, whereas USP47 knockdown inhibited gastric cancer cell proliferation."
33576460
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"Specifically, we demonstrate that USP47 is highly expressed in primary CML cells and promotes cell proliferation, while Usp47 knockout significantly prolongs the survival of BCR-ABL and BCR-ABL T315I -induced CML mice by reducing leukemia stem and progenitor cells."
33397955
eidos
"Finally , we show that depletion of USP47 induces p53 and therefore inhibits cell proliferation , colony formation , and tumor progression in cancer cell lines and a mouse xenograft model ."
32370049
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"Functional analysis shows that USP47 knockdown represses proliferation of CML cells sensitive or resistant to imatinib in vitro and in vivo."
33397955
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"Ubiquitin specific peptidase 47 promotes proliferation of lung squamous cell carcinoma."
35254655
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"Functional experimental results showed that USP47 promoted the cell proliferation in vitro and tumor growth in vivo ."
35141006
eidos
"Finally , we show that depletion of USP47 induces p53 and therefore inhibits cell proliferation , colony formation , and tumor progression in cancer cell lines and a mouse xenograft model ."
32370049
reach
"USP47 knockdown inhibits proliferation of CML cells."
33397955
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"USP47 silencing reduces proliferation and migration of colorectal cancer cells and suppresses the self-renewal of CCSCs by downregulating the expression of cancer stem cell markers, including CD44, CD133, CD166, OCT4 and NANOG."
34030041
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"Silencing Usp47 inhibits BCR-ABL T315I -induced CML and proliferation of KBM T315I in a xenograft mouse model."
33397955
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"Moreover, USP47 knockdown could repress CRC cell proliferation, which could be rescued by YAP overexpression (Pan et al., 2020)."
34604226
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"The deficiency of USP47 impaired the transcriptional activity of SATB1 target genes and inhibited cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer."
34604226
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"Downregulation of USP47 inhibited the proliferation of imatinib-sensitive or drug-resistant CML cells."
34604226
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"USP47 deficiency impairs transcriptional activity of SATB1 target genes and inhibits colon cancer cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer."
30742943
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"Here, we demonstrate that miR-101-3p regulates the RPL11-MDM2-p53 pathway by targeting ubiquitin-specific peptidase 47 (USP47), consequently inhibiting cancer cell proliferation."
35205710
USP47 affects apoptotic process
| 1 14
USP47 inhibits apoptotic process.
| 1 8
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"Knockdown of USP47 expression in human osteosarcoma U-2OS and SAOS-2 cells and breast cancer T47D, BT-20, and MCF7 cells significantly induced apoptosis and improved the sensitivity to chemotherapeutic drugs.Ubiquitin-specific peptidase 47 knockdown inhibited the proliferation of A549 lung cancer cells and PC3 prostate cancer cells by deubiquitinating β-catenin (Shi et al., 2015)."
34604226
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"Notably, selective dual inhibitors of USP7 and USP47 have been synthesized and induced accumulation of p53 and apoptosis in human cancer cell lines [XREF_BIBR]."
25481052
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"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
33643919
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"USP47 knockdown attenuated myocardial cell I/R injury by inhibiting apoptosis."
32761659
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"Compound 1, a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines."
24900381
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"USP47 facilitated osteosarcoma cell invasion and migration, and suppressed apoptosis."
33576460
eidos
"USP47 facilitated osteosarcoma cell invasion and migration , and suppressed apoptosis ( 46 ) ."
33576460
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"In agreement with this result, we observed that silencing of USP47 augments the apoptosis of MCF-7 breast cancer cells, which are known to be resistant to inhibition of NF-kappaB."
19966869
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"In cultured CRC cells, knockdown of USP47 increased pyroptosis and apoptosis induced by chemotherapeutic doxorubicin."
34630087
USP47 activates apoptotic process.
| 6
USP47 activates apoptotic process. 6 / 6
| 6
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"USP47 promotes apoptosis in rat myocardial cells after ischemia and reperfusion injury via NF-kappaB activation."
32761659
reach
"USP47 has also been described as an interaction partner for the ubiquitin E3 ligase complex, b-TrCP, with the authors of this study showing that silencing of USP47 expression inhibits cell survival and sensitises cells to chemotherapeutic agent-induced apoptosis [139] ."
23712866
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"USP47 induced apoptosis was potently counteracted by the NF-kappaB inhibitor, and cytoplasmic NF-kappaB was increased and nuclear NF-kappaB was decreased."
32761659
reach
"USP47 has also been described as an interaction partner for the ubiquitin E3 ligase complex, β-TrCP, with the authors of this study showing that silencing of USP47 expression inhibits cell survival and sensitises cells to chemotherapeutic agent-induced apoptosis [139]."
23712866
reach
"Downregulation of USP47 decreased apoptosis induced by ischemia/reperfusion injury, increased survivin and cytoplasmic NF-κB, and decreased cleaved caspase-3 and nuclear NF-κB. NF-κB inhibitors could effectively inhibit USP47-induced apoptosis, increase cytoplasmic NF-κB, and decrease nuclear NF-κB. Luciferase reporter genes showed that USP47 promoted NF-κB promoter activity."
34604226
reach
"USP47-deficient MEF cells isolated from a USP47 knockout mouse model revealed that USP47 knockout significantly increased the levels of ultraviolet-induced apoptosis (Peschiaroli et al., 2010)."
34604226
USP47 affects RPS2
| 1 2 13
USP47 binds RPS2.
| 1 13
RPS2 binds USP47. 10 / 13
| 1 12
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"As for USP47, the deficiency of UBLs impaired the binding between USP47 and RPS2, indicating that the UBLs of USP47 were also involved in substrate binding (Cho et al., 2020)."
34604226
sparser
"Next, we examined the direct interaction between USP47 and RPS2 by a Glutathione S-transferase (GST) pull-down assay using the GST-USP47 477–934 protein that includes the ubiquitin-like (UBL) domain, as the UBL domain is known to mediate protein–protein interaction [ xref ]."
32370049
sparser
"As shown in xref a, USP47 interacted with RPS2 in cells."
32370049
sparser
"Consistent with these results, we also found that endogenous RPS2 interacted with endogenous USP47 in cells ( xref b)."
32370049
sparser
"In addition, ribosomal stress decreases the interaction between RPS2 and USP47, and dissociated RPS2 can then inhibit MDM2 and subsequently lead to p53 stabilization."
32370049
sparser
"These results indicate that USP47 directly interacts with RPS2."
32370049
sparser
"Localization data also showed that interaction between USP47 and RPS2 dissociated during ribosomal stress, as shown in xref a,b."
32370049
sparser
"On the contrary, the interaction between USP47 and RPS2 was not decreased by the addition of MDM2 ( xref d and xref )."
32370049
sparser
"Since the upregulation of p53 by ribosomal proteins mainly occurred under ribosomal stress, we compared the interaction between USP47 and RPS2 under normal or ribosomal stress."
32370049
sparser
"USP47 Interacts with RPS2."
32370049
RPS2 binds USP47 and Flag. 1 / 1
| 1
sparser
"Moreover, ectopically overexpressed Flag-USP47 interacted with endogenous RPS2 ( xref )."
32370049
USP47 deubiquitinates RPS2.
| 1 1
USP47 deubiquitinates RPS2. 2 / 2
| 1 1
trips
"USP47 Promotes Tumorigenesis by Negative Regulation of p53 through Deubiquitinating Ribosomal Protein S2."
32370049
reach
"Further mechanistic studies showed that USP47 deubiquitinated RPS2, thereby inhibiting interaction between RPS2 and MDM2, and alleviated RPS2-mediated MDM2 inhibition under normal conditions, thus inhibiting P53."
34604226
USP47 affects Cell Survival
| 2 11
USP47 activates Cell Survival.
| 2 9
USP47 activates Cell Survival. 10 / 14
| 2 9
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"In the present study, USP47 was identified as a target of miR-454, and USP47 knockdown significantly inhibited cell viability and DDP resistance in NPC cells compared with the shNC group."
33576460
reach
"It was recently demonstrated that silencing of USP47 inhibits cell survival and sensitizes cells to DNA damaging agents (Peschiaroli et al., 2010)."
21362556
reach
"USP47 has also been described as an interaction partner for the ubiquitin E3 ligase complex, beta-TrCP, with the authors of this study showing that silencing of USP47 expression inhibits cell survival and sensitises cells to chemotherapeutic agent induced apoptosis [XREF_BIBR]."
23712866
reach
"Additionally, the utilization of AZD6738 (50nM), an ATR pathway inhibitor, partially inhibits USP47 knockdown induced suppression of cell viability in CML cells."
33397955
eidos
"The CCK-8 assay results demonstrated that USP47 knockdown significantly reduced cell viability compared with the shNC group , which was significantly reversed by co-transfection with miR-454 knockdown in 5-8F / DDP and SUNE-1 / DDP cells ( Fig. 6C ) ."
33576460
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"Silencing of USP47 inhibits cell survival and sensitizes cells to chemotherapic agent induced apoptosis."
19966869
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"Compared with the shNC group, USP47 knockdown significantly suppressed NPC cell viability and DDP resistance, which was significantly reversed by co-transfection with miR-454 inhibitor."
33576460
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"Silencing of USP47 decreases cell survival and augments the cytotoxic effects of antitumor drugs on a variety of tumor cells, including osteosarcoma and breast cancer cell lines."
19966869
eidos
"Compared with the shNC group , USP47 knockdown significantly suppressed NPC cell viability and DDP resistance , which was significantly reversed by co-transfection with miR-454 inhibitor ."
33576460
reach
"The CCK-8 assay results demonstrated that USP47 knockdown significantly reduced cell viability compared with the shNC group, which was significantly reversed by co-transfection with miR-454 knockdown in 5-8F/DDP and SUNE-1 and DDP cells (XREF_FIG)."
33576460
USP47 inhibits Cell Survival.
| 2
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"Notably, genetic or siRNA mediated depletion of USP47 induced accumulation of Cdc25A, decreased cell survival and augmented the cytotoxic effects of anticancer drugs."
19966869
reach
"Notably, genetic or siRNA mediated depletion of USP47 decreases cell survival and augments the anti-proliferative effect of anticancer drugs, providing a novel potential target for anticancer therapies."
19966869
SNAI1 affects USP47
| 8 8
SNAI1 binds USP47. 10 / 14
| 8 6
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"USP47 binds to Snail and triggers its deubiquitination."
29162839
reach
"However, under hypoxic conditions, USP47 binding to Snail was markedly enhanced."
29162839
sparser
"Taken together, these results indicate that USP47 interacts directly with Snail and impedes its ubiquitination and subsequent proteasomal degradation."
29162839
reach
"To visualize the interaction between Snail and USP47, we stained the DLD-1 cells with fluorescent probes detecting USP47 (red) and Snail (green)."
29162839
sparser
"This observation implies that USP47 binds to Snail and removes ubiquitins from it in the cytoplasm of DLD-1 cells."
29162839
reach
"Taken together, these results indicate that USP47 interacts directly with Snail and impedes its ubiquitination and subsequent proteasomal degradation."
29162839
sparser
"Notably, USP47 interacts directly with Snail and enhances its stability."
29162839
sparser
"However, under hypoxic conditions, USP47 binding to Snail was markedly enhanced (Fig.  xref )."
29162839
sparser
"USP47 binds to Snail and triggers its deubiquitination."
29162839
reach
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
SNAI1 binds USP47 and CXXC1. 1 / 1
| 1
sparser
"It would be worthwhile determining whether USP47 can bind to Snail at the SNAG or zinc finger domains and whether such interaction contributes to stabilization of its substarte Snail."
29162839
SATB1 binds SNAI1 and USP47. 1 / 1
| 1
sparser
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
USP47 affects CTNNB1
1 | 9 4
USP47 binds CTNNB1.
| 3 4
USP47 binds CTNNB1. 5 / 5
| 3 2
sparser
"USP47 directly interacts with β-catenin and affects Wnt/β-catenin signaling by deubiquitination of β-catenin."
32486158
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"Both USP15 and USP47 form a complex with beta-catenin leading to its deubiquitination and stabilization [248,249]."
28923280
sparser
"The interaction between β-catenin and USP47 protein was weakened with the loss of FAM83H and increased with overexpression of FAM83H ( xref )."
32564009
reach
"Although it has been reported that MAPK or beta-catenin interacts with USP47 in Drosophila or tumors XREF_BIBR, XREF_BIBR, USP47 knockdown does not affect the expression of MAPK or beta-catenin in CML cells."
33397955
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"USP47 directly interacts with beta-catenin and affects Wnt and beta-catenin signaling by deubiquitination of beta-catenin."
32486158
MAPK binds USP47 and CTNNB1. 1 / 1
| 1
sparser
"Although it has been reported that MAPK or β-catenin interacts with USP47 in Drosophila or tumors xref , xref , USP47 knockdown does not affect the expression of MAPK or β-catenin in CML cells (Supplementary Fig.  xref )."
33397955
USP47 binds CTNNB1 and fbxw1. 1 / 1
| 1
sparser
"Importantly, mutation of Arginine 434 to alanine abrogated the binding of β-Trcp with both USP47 and β-catenin ( xref , lane 10), indicating that the β-Trcp-USP47 association is comparable with other β-Trcp-substrate interactions."
19966869
USP47 activates CTNNB1.
| 3
USP47 activates CTNNB1. 3 / 3
| 3
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
34604226
reach
"The results indicate that USP47 induces a positive process in Wnt and beta-catenin signaling while increasing the stability of beta-catenin [XREF_BIBR, XREF_BIBR]."
32486158
reach
"GSK-3β inactivated by its upstream Akt and ubiquitin-specific protease 47 (USP47) has been shown to inhibit β-catenin degradation."
36813838
USP47 deubiquitinates CTNNB1.
1 | 1
USP47 deubiquitinates CTNNB1. 2 / 2
1 | 1
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
ubibrowser
"Additionally, DUBs USP14, USP15, USP47, and Fam/USP9X have been reported to prevent β-catenin turnover by inhibiting its Ub-proteasomal degradation"
29080116
USP47 ubiquitinates CTNNB1.
| 1
USP47 leads to the ubiquitination of CTNNB1. 1 / 1
| 1
reach
"Inactivation of USP47 by RNAi increased beta-catenin ubiquitination, attenuated Wnt signaling, and repressed cancer cell growth."
26169834
USP47 decreases the amount of CTNNB1.
| 1
USP47 decreases the amount of CTNNB1. 1 / 1
| 1
reach
"Besides, USP47 knockout could increase E-cadherin expression and inhibited β-catenin expression in HCT116 cells, which is the reverse process of EMT."
34604226
RPS2 affects USP47
| 1 13
RPS2 binds USP47. 10 / 13
| 1 12
reach
"As for USP47, the deficiency of UBLs impaired the binding between USP47 and RPS2, indicating that the UBLs of USP47 were also involved in substrate binding (Cho et al., 2020)."
34604226
sparser
"Next, we examined the direct interaction between USP47 and RPS2 by a Glutathione S-transferase (GST) pull-down assay using the GST-USP47 477–934 protein that includes the ubiquitin-like (UBL) domain, as the UBL domain is known to mediate protein–protein interaction [ xref ]."
32370049
sparser
"As shown in xref a, USP47 interacted with RPS2 in cells."
32370049
sparser
"Consistent with these results, we also found that endogenous RPS2 interacted with endogenous USP47 in cells ( xref b)."
32370049
sparser
"In addition, ribosomal stress decreases the interaction between RPS2 and USP47, and dissociated RPS2 can then inhibit MDM2 and subsequently lead to p53 stabilization."
32370049
sparser
"These results indicate that USP47 directly interacts with RPS2."
32370049
sparser
"Localization data also showed that interaction between USP47 and RPS2 dissociated during ribosomal stress, as shown in xref a,b."
32370049
sparser
"On the contrary, the interaction between USP47 and RPS2 was not decreased by the addition of MDM2 ( xref d and xref )."
32370049
sparser
"Since the upregulation of p53 by ribosomal proteins mainly occurred under ribosomal stress, we compared the interaction between USP47 and RPS2 under normal or ribosomal stress."
32370049
sparser
"USP47 Interacts with RPS2."
32370049
RPS2 binds USP47 and Flag. 1 / 1
| 1
sparser
"Moreover, ectopically overexpressed Flag-USP47 interacted with endogenous RPS2 ( xref )."
32370049
reach
"Ubiquitin-specific peptidase 47 also helps to promote EMT in normal cells (Silvestrini et al., 2020)."
34604226
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"These results suggested that USP47 could mediate EMT by stabilizing SATB1 (Yu et al., 2019)."
34604226
reach
"Because hypoxia induced USP47 expression enhanced EMT by stabilizing Snail, we investigated the contribution of USP47 to tumor growth and invasion in vivo."
29162839
reach
"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
34604226
reach
"Here we report that upregulation of USP47 under hypoxic conditions stimulates EMT in CRC cells and subsequently their metastatic potential."
29162839
reach
"However, the relationship between EMT mediated by USP47 and E-cadherin was not explored in this study."
34604226
reach
"Silencing of USP47 accelerated the proteasomal degradation of Snail and inhibited EMT."
29162839
reach
"By utilizing the microarray database system of the Cancer Genome Atlas, we identified ubiquitin specific protease 47 (USP47), a deubiquitinating enzyme, as a potential mediator of hypoxia induced EMT."
29162839
reach
"The enhancement of USP47 in colorectal cancer cells under hypoxic conditions induced the disassembly of E-cadherin and promoted EMT through deubiquitination of Snail."
29162839
USP47 increases the amount of epithelial to mesenchymal transition.
| 2
reach
"In line with the in vitro findings, knockdown of USP47 abrogated the expression of EMT markers in transplanted tumors, and this led to suppression of progression and invasiveness of CRC cells."
29162839
reach
"After validating USP47 alterations using MRM and antibody based assays, we demonstrated that the chemical inhibition of USP47 with the inhibitor P5091 reduced expression of EMT markers and reverted morphological changes in MCF-10A cells undergoing EMT."
32201364
reach
"Silencing of USP47 promotes EMT in CRC cells under hypoxic conditions."
29162839
USP47 affects MAPK
| 8 4
USP47 binds MAPK.
| 3 4
MAPK binds USP47. 5 / 5
| 3 2
sparser
"The results of GST pull-down experiment displayed that USP47 directly interacted with MAPK in vitro ( xref )."
33489876
reach
"The results of GST pull-down experiment displayed that USP47 directly interacted with MAPK in vitro (XREF_FIG)."
33489876
reach
"At the cellular level, interactions between USP47 and MAPK were detected in both overexpression and endogenous experiments (XREF_FIG)."
33489876
sparser
"At the cellular level, interactions between USP47 and MAPK were detected in both overexpression and endogenous experiments ( xref )."
33489876
reach
"Although it has been reported that MAPK or beta-catenin interacts with USP47 in Drosophila or tumors XREF_BIBR, XREF_BIBR, USP47 knockdown does not affect the expression of MAPK or beta-catenin in CML cells."
33397955
MAPK binds USP47 and CTNNB1. 1 / 1
| 1
sparser
"Although it has been reported that MAPK or β-catenin interacts with USP47 in Drosophila or tumors xref , xref , USP47 knockdown does not affect the expression of MAPK or β-catenin in CML cells (Supplementary Fig.  xref )."
33397955
MAPK binds USP47 and E2F7. 1 / 1
| 1
sparser
"The interaction between E2F7, miR-199b, USP47, and MAPK was identified by ChIP-Seq analysis, luciferase reporter, RNA pull-down, co-immunoprecipitation, as well as glutathione-S-transferase (GST) pull-down experiments."
33489876
USP47 decreases the amount of MAPK.
| 2
USP47 decreases the amount of MAPK. 2 / 2
| 2
reach
"Like many of the candidates identified in our initial genome-wide screen, Usp47 RNAi was found to cause a decrease in MAPK protein levels (XREF_FIG) [XREF_BIBR], whereas it did not visibly alter the expression levels of JNK (FBgn0000229) and p38b (FBgn0024846), two other members of the MAPK family, nor of other RAS-MAPK pathway proteins (XREF_FIG)."
27552662
reach
"However, as Usp47 RNAi only partially depletes MAPK levels compared to the effect of mapk dsRNA itself (XREF_FIG), it might be expected that another DUB is acting redundantly to protect MAPK from complete degradation, in which case this factor should display an aggravating genetic interaction with Usp47 RNAi (XREF_SUPPLEMENTARY)."
27552662
USP47 inhibits MAPK.
| 1
USP47 inhibits MAPK. 1 / 1
| 1
reach
"We found labeled MAPK to be degraded more rapidly in cells treated with Usp47 RNAi (XREF_FIG)."
27552662
USP47 deubiquitinates MAPK.
| 1
USP47 deubiquitinates MAPK. 1 / 1
| 1
reach
"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
USP47 activates MAPK.
| 1
USP47 activates MAPK. 1 / 1
| 1
reach
"Moreover, this event appears to be specific to MAPK, as no other core components of the pathway nor other Drosophila MAPK like proteins, JNK (bsk; FBgn0000229) and p38B (FBgn0015765), are modulated by USP47 function."
27552662
USP47 affects KIFC3
2 | 5 1
USP47 binds KIFC3.
2 | 4 1
USP47 binds KIFC3. 7 / 10
2 | 4 1
sparser
"Here we find that KIFC3 binds the ubiquitin-specific protease USP47, a protease that removes ubiquitin chains from substrates and hence inhibits proteasome-mediated proteolysis, and recruits it to AJs."
25253721
reach
"p120-catenin may serve E-cadherin stabilization by leading the KIFC3 and USP47 complex to these junctions."
25253721
biogrid
No evidence text available
25253721
biogrid
No evidence text available
25253721
reach
"Of note, the KIFC3 and USP47 complex was detected throughout the cytoplasm."
25253721
reach
"Double staining for E-cadherin and endogenous KIFC3 or USP47 also showed their overlapping distributions (XREF_FIG), indicating that the KIFC3 and USP47 complex accumulates at the AJs or zonula adherens (ZA), the epithelial form of an AJ."
25253721
reach
"Our detailed analysis of the function of the KIFC3 and USP47 complex suggests that it suppresses E-cadherin degradation and internalization."
25253721
USP47 activates KIFC3.
| 1
USP47 activates KIFC3. 1 / 1
| 1
reach
"Expression of murine KIFC3-FLAG in cells treated with KIFC3 siRNA or an siRNA resistant mutant of USP47-FLAG in cells treated with USP47 siRNA suppressed the generation of AbH-108-positive E-cadherin vesicles (Supplemental Figure S2)."
25253721
USP47 affects DNA Damage
| 11
USP47 activates DNA Damage.
| 9
USP47 activates DNA Damage. 9 / 9
| 9
reach
"Mechanistic studies have shown that stable Y-box binding protein 1 (YB-1) contributed to USP47-mediated DNA damage repair in CML cells."
34604226
reach
"USP47 overexpression in YB-1 and/or Polbeta depletion cells can not abrogate gammaH 2 AX expression, indicating that YB-1 contributes more to USP47 mediated DNA damage repair than Polbeta in CML cells."
33397955
reach
"The results indicate that YB-1 is involved in USP47 mediated DNA damage repair in CML cells."
33397955
reach
"We further demonstrated that YB-1, a novel substrate of USP47, contributes to USP47 mediated DNA damage repair."
33397955
reach
"To assess the contribution of YB-1 and Polbeta to USP47 mediated DNA damage repair in CML cells, we overexpressed USP47 in YB-1 and/or POLB knockdown K562 and KBM5 T315I cells."
33397955
reach
"YB-1 contributes to USP47 mediated DNA damage repair in CML cells."
33397955
reach
"Taken together, these data demonstrate that by controlling stability of the cytoplasmic form of Pol beta, USP47 modulates the efficiency of DNA damage repair by the BER pathway and maintains genome in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21362556
reach
"As a substrate of USP47, YB-1 contributes to USP47 mediated DNA damage repair in CML cells."
33397955
reach
"Mechanistic studies show that stabilizing Y-box binding protein 1 contributes to USP47 mediated DNA damage repair in CML cells."
33397955
USP47 inhibits DNA Damage.
| 2
USP47 inhibits DNA Damage. 2 / 2
| 2
reach
"As DNA damage repair plays an essential role in the maintenance or generation of CML stem and progenitor cells XREF_BIBR, XREF_BIBR, we hypothesized that DNA damage induced by USP47 knockdown might be vital to CML stem and progenitor cells."
33397955
reach
"Phenolic compounds not only inhibited the 26S activity but also decreased the USP47 levels, which reduce the DNA damage repair rate during oxidative stress; in addition, the presence of DNA fragments, procaspase-3 and a decreased poly (ADP-ribose) polymerase also appeared as a result of the above conditions."
24075904
Fbxw1 affects USP47
| 7 3
Fbxw1 binds USP47.
| 5 3
USP47 binds fbxw1. 7 / 7
| 5 2
sparser
"These data showed that USP47 interacts specifically with β-Trcp."
19966869
reach
"To confirm the specific binding between USP47 and beta-Trcp, we screened 19 human F-box proteins."
19966869
reach
"To analyze whether the physical interaction between USP47 and beta-Trcp resulted into a proteasome dependent degradation of USP47, we first analyzed the effect of the proteasome inhibitor MG132 on USP47 protein levels."
19966869
sparser
"Unexpectedly, the USP47 (S914/918A) mutant bound endogenous β-Trcp with the same efficiency as the wild-type protein ( xref , lanes 2 and 3)."
19966869
reach
"The specificity of the binding between USP47 and beta-Trcp and the similarity of the phenotypes produced by targeting USP47 or beta-Trcp suggested to us that USP47 could be a regulator of beta-Trcp activity."
19966869
reach
"These data showed that USP47 interacts specifically with beta-Trcp."
19966869
reach
"To analyze whether the binding between beta-Trcp and USP47 requires the WD40-repeat domain and an intact Arg434, we performed co-immunoprecipitation experiments using different beta Trcp mutants (all FLAG tagged)."
19966869
USP47 binds CTNNB1 and fbxw1. 1 / 1
| 1
sparser
"Importantly, mutation of Arginine 434 to alanine abrogated the binding of β-Trcp with both USP47 and β-catenin ( xref , lane 10), indicating that the β-Trcp-USP47 association is comparable with other β-Trcp-substrate interactions."
19966869
Fbxw1 activates USP47.
| 2
Fbxw1 activates USP47. 2 / 2
| 2
reach
"Depletion of beta-Trcp by siRNA did not induce stabilization of USP47 (XREF_FIG)."
19966869
reach
"However, we can not rule out the possibility that beta-Trcp might target USP47 for proteasome dependent degradation in response to a stimulus that we did not analyze."
19966869
USP47 affects TP53
| 4 5 1
USP47 inhibits TP53.
| 3 3
USP47 inhibits TP53. 6 / 6
| 3 3
reach
"Compound 1, a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines."
24900381
reach
"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
33643919
eidos
"Finally , we provide evidence that USP47 has oncogenic potential , and depletion of USP47 induces p53 by regulation of RPS2 and , therefore , inhibits cell proliferation , colony formation , and tumor progression in cancer cell lines and a mouse xenograft model in a p53-dependent manner ."
32370049
eidos
"Finally , we show that depletion of USP47 induces p53 and therefore inhibits cell proliferation , colony formation , and tumor progression in cancer cell lines and a mouse xenograft model ."
32370049
reach
"Notably, selective dual inhibitors of USP7 and USP47 have been synthesized and induced accumulation of p53 and apoptosis in human cancer cell lines [XREF_BIBR]."
25481052
eidos
"As shown in Figure 2a , the depletion of USP47 increased the p53 level but not in the presence of MG132 ."
32370049
USP47 ubiquitinates TP53.
| 1
USP47 ubiquitinates TP53. 1 / 1
| 1
sparser
"The ubiquitination of p53 or MDM2 was examined, and the results showed that p53 ubiquitination by MDM2 was increased by USP47 but not by USP47 C109S in the presence of RPS2 ( xref a)."
32370049
USP47 increases the amount of TP53.
| 1
USP47 increases the amount of TP53. 1 / 1
| 1
reach
"USP47 knockdown led to an increased binding of RPS2 to MDM2, inhibiting MDM2 activity and upregulating p53 levels under ribosomal stress, thereby inhibiting cell proliferation, colony formation, and tumor progression (Cho et al., 2020)."
34604226
USP47 decreases the amount of TP53.
| 1
USP47 decreases the amount of TP53. 1 / 1
| 1
reach
"USP47 knockdown led to an increased binding of RPS2 to MDM2, inhibiting MDM2 activity and upregulating p53 levels under ribosomal stress, thereby inhibiting cell proliferation, colony formation, and tumor progression (Cho et al., 2020)."
34604226
USP47 activates TP53.
| 1
USP47 activates TP53. 1 / 1
| 1
eidos
"Interestingly , p53 decrease by USP47 overexpression and p53 increase by USP47 knockdown were only shown in the MDM2 + / + p53 - / - MEF cell line , while there were no significant p53 level changes in the MDM2 - / - p53 - / - MEF cell line ( Figure 2e , f ) ."
32370049
USP47 affects FBXW11
9 | 1
FBXW11 binds USP47. 10 / 10
9 | 1
biogrid
No evidence text available
25332235
biogrid
No evidence text available
19966869
biogrid
No evidence text available
22017875
sparser
"Recently, the involvement of βTrCP-bound deubiquitylase enzyme USP47 has been described in HH signaling."
32531973
biogrid
No evidence text available
25515538
biogrid
No evidence text available
25900982
biogrid
No evidence text available
19615732
biogrid
No evidence text available
25900982
biogrid
No evidence text available
25332235
biogrid
No evidence text available
28514442
KIFC3 affects USP47
2 | 4 1
USP47 binds KIFC3. 7 / 10
2 | 4 1
sparser
"Here we find that KIFC3 binds the ubiquitin-specific protease USP47, a protease that removes ubiquitin chains from substrates and hence inhibits proteasome-mediated proteolysis, and recruits it to AJs."
25253721
reach
"p120-catenin may serve E-cadherin stabilization by leading the KIFC3 and USP47 complex to these junctions."
25253721
biogrid
No evidence text available
25253721
biogrid
No evidence text available
25253721
reach
"Of note, the KIFC3 and USP47 complex was detected throughout the cytoplasm."
25253721
reach
"Double staining for E-cadherin and endogenous KIFC3 or USP47 also showed their overlapping distributions (XREF_FIG), indicating that the KIFC3 and USP47 complex accumulates at the AJs or zonula adherens (ZA), the epithelial form of an AJ."
25253721
reach
"Our detailed analysis of the function of the KIFC3 and USP47 complex suggests that it suppresses E-cadherin degradation and internalization."
25253721
FBXW11 affects USP47
9 | 1
FBXW11 binds USP47. 10 / 10
9 | 1
biogrid
No evidence text available
25332235
biogrid
No evidence text available
19966869
biogrid
No evidence text available
22017875
sparser
"Recently, the involvement of βTrCP-bound deubiquitylase enzyme USP47 has been described in HH signaling."
32531973
biogrid
No evidence text available
25515538
biogrid
No evidence text available
25900982
biogrid
No evidence text available
19615732
biogrid
No evidence text available
25900982
biogrid
No evidence text available
25332235
biogrid
No evidence text available
28514442
USP7 affects USP47
| 3 6
USP7 binds USP47.
| 1 6
USP7 binds USP47. 5 / 5
| 1 4
sparser
"This study showed that chemical inhibition of USP7 and USP47 blocked inflammasome formation and that although both DUBs contributed to inflammasome activation, its activation was majorly impaired when both USP7 and USP47 were not present."
31679183
sparser
"Whether USP7 and USP47 directly interact with NLRP3 receptor or with other inflammasome component was not investigated."
31679183
sparser
"Furthermore, activated inflammasomes also regulate USP7 and USP47 activity, which forms a positive feedback pathway for resistance to pathogen infection (Palazon-Riquelme et al., 2018)."
34966378
sparser
"Furthermore, activated inflammasomes also regulate USP7 and USP47 activity, which forms a positive feedback pathway for resistance to pathogen infection ( xref )."
34966378
reach
"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [XREF_BIBR]."
33138315
SHBG binds USP7 and USP47. 1 / 1
| 1
sparser
"Strikingly, treatment of LPS‐primed MDMs with nigericin induced a dramatic increase in the proportion of ABP‐bound USP7 and USP47 (Fig xref A)."
30206189
USP7 binds NLRP3 and USP47. 1 / 1
| 1
sparser
"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [ xref ]."
33138315
USP7 inhibits USP47.
| 2
USP7 inhibits USP47. 2 / 2
| 2
reach
"Due to the multifaceted roles of USP7, many inhibitors have been developed targeting USP7, such as P022077, HBX 41,108, HBX-19,818, HBX-28,258, P5091, Cpd 14 and P22077, in which the latter two molecules also inhibit USP47 [XREF_BIBR - XREF_BIBR]."
28031783
reach
"Due to the multifaceted roles of USP7, many inhibitors have been developed targeting USP7, such as P022077, HBX 41,108, HBX-19,818, HBX-28,258, P5091, Cpd 14 and P22077, in which the latter two molecules also inhibit USP47."
28279784
USP47 affects fbxw1
| 6 3
USP47 binds fbxw1.
| 5 3
USP47 binds fbxw1. 7 / 7
| 5 2
sparser
"These data showed that USP47 interacts specifically with β-Trcp."
19966869
reach
"To confirm the specific binding between USP47 and beta-Trcp, we screened 19 human F-box proteins."
19966869
reach
"To analyze whether the physical interaction between USP47 and beta-Trcp resulted into a proteasome dependent degradation of USP47, we first analyzed the effect of the proteasome inhibitor MG132 on USP47 protein levels."
19966869
sparser
"Unexpectedly, the USP47 (S914/918A) mutant bound endogenous β-Trcp with the same efficiency as the wild-type protein ( xref , lanes 2 and 3)."
19966869
reach
"The specificity of the binding between USP47 and beta-Trcp and the similarity of the phenotypes produced by targeting USP47 or beta-Trcp suggested to us that USP47 could be a regulator of beta-Trcp activity."
19966869
reach
"These data showed that USP47 interacts specifically with beta-Trcp."
19966869
reach
"To analyze whether the binding between beta-Trcp and USP47 requires the WD40-repeat domain and an intact Arg434, we performed co-immunoprecipitation experiments using different beta Trcp mutants (all FLAG tagged)."
19966869
USP47 binds CTNNB1 and fbxw1. 1 / 1
| 1
sparser
"Importantly, mutation of Arginine 434 to alanine abrogated the binding of β-Trcp with both USP47 and β-catenin ( xref , lane 10), indicating that the β-Trcp-USP47 association is comparable with other β-Trcp-substrate interactions."
19966869
USP47 inhibits fbxw1.
| 1
USP47 inhibits fbxw1. 1 / 1
| 1
reach
"ERAP1 promotes Hedgehog dependent tumorigenesis by controlling USP47 mediated degradation of betaTrCP."
31341163
USP47 affects NLRP3
| 8 1
USP47 activates NLRP3.
| 4
USP47 activates NLRP3. 4 / 4
| 4
reach
"Inhibition of USP7 and USP47 impairs NLRP3 inflammasome activation in macrophages."
30206189
reach
"In addition, inhibition of USP7 and USP47 blocks the NLRP3 inflammasome by preventing apeck-like protein containing a CARD (ASC) oligomerization and speck formation in macrophages [38]."
32650621
reach
"Moreover, USP7, USP47, and BRCC3 and ABRO can activate the NLRP3 inflammasome."
32850399
reach
"It is then possible that this process is regulated by K11 linked ubiquitin chains, yet it is also possible that USP7 and USP47 do not directly target NLRP3 and that an additional regulated protein, upstream of this process, is mediating this effect."
30206189
USP47 deubiquitinates NLRP3.
| 3
USP47 deubiquitinates NLRP3. 3 / 3
| 3
reach
"However, it is not clear whether USP7 and USP47 directly contribute to NLRP3 deubiquitination or regulate the process somewhere upstream of NLRP3 inflammasome action [108]."
| PMC
reach
"USP47 reversed the ubiquitination of NLRP3."
35678979
reach
"Conversely, deubiquitination of NLRP3 by USP7 and USP47 positively regulates inflammasome activation and USP47 is significantly downregulated in dopaminergic neurons from idiopathic PD patient post-mortem brain samples [XREF_BIBR, XREF_BIBR]."
33414510
USP47 ubiquitinates NLRP3.
| 1
USP47 ubiquitinates NLRP3. 1 / 1
| 1
reach
"The relationship among ZNF883, miR-138-5p, and USP47 as well as the regulation of NLRP3 ubiquitination by USP47 was determined."
35678979
USP47 binds NLRP3.
| 1
USP7 binds NLRP3 and USP47. 1 / 1
| 1
sparser
"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [ xref ]."
33138315
P22077 affects USP47
| 1 8
P22077 inhibits USP47.
| 1 7
P22077 inhibits USP47. 8 / 8
| 1 7
reach
"P22077 and PR-619 are specific inhibitors of USP7 and USP47, which inhibit Gag processing and reduce the release ofinfectious virions in HIV-1 infection [60]."
34803084
reach
"These data were consistent with the in vitro enzyme characterization data, demonstrating that PR-619 exhibits a broad inhibition profile whereas P22077 is a selective inhibitor of USP7 and USP47."
22613766
reach
"Data from these studies demonstrate that P22077 inhibits USP7 and the closely related DUB USP47."
22118674
reach
"It has been reported that P22077, a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, inhibited the proliferation of HIV virus by inhibiting the function of USP47 [27]."
31982568
reach
"P22077 may promote the degradation of USP47 by inhibiting the auto-deubiquitinating process of USP47 28, which is supported by the finding that MG132 reverses P22077 induced USP47 degradation."
33397955
reach
"In this regard, P22077 was reported to inhibit Usp47."
28246399
reach
"We observed that P22077 inhibited IL-1beta, IL-18 and caspase-1 cleavage and release, as well as pyroptotic cell death (Fig XREF_FIG A-D), indicating that USP7 and/or the closely related DUB USP47 are important for inflammasome activation."
30206189
eidos
"Inhibiting USP47 by P22077 exerts cytotoxicity to CML cells with or without TKI resistance in vitro and in vivo ."
33397955
P22077 decreases the amount of USP47.
| 1
P22077 decreases the amount of USP47. 1 / 1
| 1
reach
"Interestingly, in addition to inhibiting the activity of USP47, P22077 considerably reduces the protein level of USP47 in CML cells."
33397955
USP47 affects YBX1
| 5 3
USP47 binds YBX1.
| 2 3
USP47 binds YBX1. 4 / 4
| 1 3
sparser
"The results show that USP47 interacts with the C-terminal domain (CTD) domain of YB-1 (Fig.  xref )."
33397955
sparser
"It was identified that YB-1 can interact with USP47 in K562 and primary CML cells (Fig.  xref )."
33397955
sparser
"Interestingly, the interaction between YB-1 and USP47 is not affected by the ubiquitination status of YB-1, as the mutation of lysine residues (Lys137, −164, and −170) abrogates the ubiquitination of YB-1, but not its interaction with USP47 (Fig.  xref )."
33397955
reach
"Interestingly, the interaction between YB-1 and USP47 is not affected by the ubiquitination status of YB-1, as the mutation of lysine residues (Lys137, -164, and -170) abrogates the ubiquitination of YB-1, but not its interaction with USP47."
33397955
USP47 binds YBX1 and K562. 1 / 1
| 1
reach
"It was identified that YB-1 can interact with USP47 in K562 and primary CML cells."
33397955
USP47 activates YBX1.
| 2
USP47 activates YBX1. 2 / 2
| 2
reach
"In contrast, USP47 knockdown or P22077 treatment reduces the half-life of YB-1."
33397955
reach
"We then investigated whether USP47 influences the stability of YB-1 and found that transient transfection of USP47 prolonged the half-life of YB-1 in K562 cells."
33397955
USP47 deubiquitinates YBX1.
| 1
Modified USP47 leads to the deubiquitination of YBX1. 1 / 1
| 1
reach
"XREF_FIG, USP47 overexpression significantly inhibits ubiquitination of full-length YB-1 and YB-1-S3, but not that of the truncated YB-1-S2, which can not bind USP47."
33397955
USP47 affects CDC25A
| 8
USP47 activates CDC25A.
| 4
USP47 activates CDC25A. 4 / 4
| 4
reach
"Moreover, we found that in response to hydroxyurea, Cdc25A was degraded in USP47 depleted cells to similar levels as in control cells (XREF_FIG), implying a transcriptional regulation of Cdc25A induced by USP47 depletion."
19966869
reach
"Notably, genetic or siRNA mediated depletion of USP47 induced accumulation of Cdc25A, decreased cell survival and augmented the cytotoxic effects of anticancer drugs."
19966869
reach
"Moreover, USP47 depletion induced upregulation of Cdc25A to similar levels as the silencing of betaTrcp (XREF_SUPPLEMENTARY)."
19966869
reach
"Depletion of USP47 induced accumulation of Cdc25A and decreased cell survival [XREF_BIBR]."
28122328
USP47 increases the amount of CDC25A.
| 3
USP47 increases the amount of CDC25A. 3 / 3
| 3
reach
"To verify this, we performed a quantitative real-time PCR and we found that USP47 but not beta-Trcp depletion increases Cdc25A mRNA levels (XREF_FIG)."
19966869
reach
"Although we have not elucidated yet the precise mechanism through which USP47 depletion causes Cdc25A upregulation, our results suggest that USP47 could potentially regulate Cdc25A expression at a transcriptional level."
19966869
reach
"Collectively, these results showed that USP47 potentially regulates Cdc25A expression at mRNA level, suggesting that USP47 does not regulate beta-Trcp activity."
19966869
USP47 decreases the amount of CDC25A.
| 1
USP47 decreases the amount of CDC25A. 1 / 1
| 1
reach
"Silencing of USP47 increases Cdc25A protein levels."
19966869
Valproic acid affects USP47
7 |
Valproic acid decreases the amount of USP47. 7 / 7
7 |
ctd
No evidence text available
25192806
ctd
No evidence text available
26272509
ctd
No evidence text available
23179753
ctd
No evidence text available
28001369
ctd
No evidence text available
24383497
ctd
No evidence text available
24935251
ctd
No evidence text available
27188386
USP47 affects USP7
| 1 6
USP7 binds USP47. 5 / 5
| 1 4
sparser
"This study showed that chemical inhibition of USP7 and USP47 blocked inflammasome formation and that although both DUBs contributed to inflammasome activation, its activation was majorly impaired when both USP7 and USP47 were not present."
31679183
sparser
"Whether USP7 and USP47 directly interact with NLRP3 receptor or with other inflammasome component was not investigated."
31679183
sparser
"Furthermore, activated inflammasomes also regulate USP7 and USP47 activity, which forms a positive feedback pathway for resistance to pathogen infection (Palazon-Riquelme et al., 2018)."
34966378
sparser
"Furthermore, activated inflammasomes also regulate USP7 and USP47 activity, which forms a positive feedback pathway for resistance to pathogen infection ( xref )."
34966378
reach
"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [XREF_BIBR]."
33138315
SHBG binds USP7 and USP47. 1 / 1
| 1
sparser
"Strikingly, treatment of LPS‐primed MDMs with nigericin induced a dramatic increase in the proportion of ABP‐bound USP7 and USP47 (Fig xref A)."
30206189
USP7 binds NLRP3 and USP47. 1 / 1
| 1
sparser
"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [ xref ]."
33138315
USP47 affects SATB1
| 5 2
USP47 binds SATB1.
| 1 2
SATB1 binds USP47. 2 / 2
| 1 1
sparser
"USP47 interacted with SATB1 through its catalytic core domain and antagonized Smurf2-mediated SATB1 degradation."
34604226
reach
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
SATB1 binds SNAI1 and USP47. 1 / 1
| 1
sparser
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
USP47 activates SATB1.
| 2
USP47 activates SATB1. 2 / 2
| 2
reach
"These results suggested that USP47 could mediate EMT by stabilizing SATB1 (Yu et al., 2019)."
34604226
reach
"The deficiency of USP47 impaired the transcriptional activity of SATB1 target genes and inhibited cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer."
34604226
USP47 ubiquitinates SATB1.
| 1
USP47 ubiquitinates SATB1. 1 / 1
| 1
reach
"Reversible Regulation of SATB1 Ubiquitination by USP47 and SMURF2 Mediates Colon Cancer Cell Proliferation and Tumor Progression."
30742943
USP47 inhibits SATB1.
| 1
USP47 inhibits SATB1. 1 / 1
| 1
reach
"USP47 deficiency impairs transcriptional activity of SATB1 target genes and inhibits colon cancer cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer."
30742943
MAPK affects USP47
| 3 4
MAPK binds USP47. 5 / 5
| 3 2
sparser
"The results of GST pull-down experiment displayed that USP47 directly interacted with MAPK in vitro ( xref )."
33489876
reach
"The results of GST pull-down experiment displayed that USP47 directly interacted with MAPK in vitro (XREF_FIG)."
33489876
reach
"At the cellular level, interactions between USP47 and MAPK were detected in both overexpression and endogenous experiments (XREF_FIG)."
33489876
sparser
"At the cellular level, interactions between USP47 and MAPK were detected in both overexpression and endogenous experiments ( xref )."
33489876
reach
"Although it has been reported that MAPK or beta-catenin interacts with USP47 in Drosophila or tumors XREF_BIBR, XREF_BIBR, USP47 knockdown does not affect the expression of MAPK or beta-catenin in CML cells."
33397955
MAPK binds USP47 and CTNNB1. 1 / 1
| 1
sparser
"Although it has been reported that MAPK or β-catenin interacts with USP47 in Drosophila or tumors xref , xref , USP47 knockdown does not affect the expression of MAPK or β-catenin in CML cells (Supplementary Fig.  xref )."
33397955
MAPK binds USP47 and E2F7. 1 / 1
| 1
sparser
"The interaction between E2F7, miR-199b, USP47, and MAPK was identified by ChIP-Seq analysis, luciferase reporter, RNA pull-down, co-immunoprecipitation, as well as glutathione-S-transferase (GST) pull-down experiments."
33489876
CTNNB1 affects USP47
| 3 4
USP47 binds CTNNB1. 5 / 5
| 3 2
sparser
"USP47 directly interacts with β-catenin and affects Wnt/β-catenin signaling by deubiquitination of β-catenin."
32486158
reach
"Both USP15 and USP47 form a complex with beta-catenin leading to its deubiquitination and stabilization [248,249]."
28923280
sparser
"The interaction between β-catenin and USP47 protein was weakened with the loss of FAM83H and increased with overexpression of FAM83H ( xref )."
32564009
reach
"Although it has been reported that MAPK or beta-catenin interacts with USP47 in Drosophila or tumors XREF_BIBR, XREF_BIBR, USP47 knockdown does not affect the expression of MAPK or beta-catenin in CML cells."
33397955
reach
"USP47 directly interacts with beta-catenin and affects Wnt and beta-catenin signaling by deubiquitination of beta-catenin."
32486158
MAPK binds USP47 and CTNNB1. 1 / 1
| 1
sparser
"Although it has been reported that MAPK or β-catenin interacts with USP47 in Drosophila or tumors xref , xref , USP47 knockdown does not affect the expression of MAPK or β-catenin in CML cells (Supplementary Fig.  xref )."
33397955
USP47 binds CTNNB1 and fbxw1. 1 / 1
| 1
sparser
"Importantly, mutation of Arginine 434 to alanine abrogated the binding of β-Trcp with both USP47 and β-catenin ( xref , lane 10), indicating that the β-Trcp-USP47 association is comparable with other β-Trcp-substrate interactions."
19966869
YAP1 affects USP47
| 6
YAP1 binds USP47. 6 / 6
| 6
sparser
"In co-immunoprecipitation (Co-IP) assays, recombinant USP47 could pull-down YAP and vice versa , suggesting that USP47 and YAP physically interact with each other (Fig.  xref A)."
31748975
sparser
"To verify this hypothesis, we first tested the interaction between USP47 and YAP."
31748975
sparser
"Taken together, these results indicate that YAP physically interacts with USP47, and USP47 serves as a DUB for YAP."
31748975
sparser
"This suggests that the USP47-YAP signalling axis in the Hippo pathway may mediate NLRP3 activation and regulate immune and inflammatory responses."
35145062
sparser
"In summary, we uncovered an USP47-YAP signaling axis in regulating the development of CRC."
31748975
sparser
"In addition, USP47 interacts with YAP, promotes YAP transcriptional activity and protein stability, and is the interactor for β-Trcp, an E3 ubiquitin ligase, leading to NLR family pyrin domain-containing (NLRP)3 proteasomal degradation via Lys27-linked polyubiquitination at Lys380."
35145062
USP47 affects Neoplasms
| 2 4
USP47 activates Neoplasms. 6 / 6
| 2 4
reach
"Ubiquitin-specific peptidase 47 expression is elevated in many tumors and is involved in multiple expression regulating mechanisms, including transcriptional, post-transcriptional, and post-translational modifications."
34604226
eidos
"Previous reports indicated that USP47 promotes colorectal cancer EMT and malignancy by stabilizing Snail and activating the Wnt signaling pathway [ 64 ] ."
31133011
reach
"Furthermore, xenograft assays demonstrated that silencing USP47 can inhibit LUSC tumor growth in vivo."
35254655
reach
"Functional experimental results showed that USP47 promoted the cell proliferation in vitro and tumor growth in vivo ."
35141006
reach
"Overexpression of USP47 could reduce the tumor inhibition induced by LINC00668 knockout (Hu et al., 2019)."
34604226
eidos
"Thus , the findings here indicate that USP47 can promote tumor proliferation by regulating levels of p53 ."
32370049
USP47 affects Flag
| 6
USP47 binds Flag. 5 / 5
| 5
sparser
"In addition, cell lysates obtained without the overexpression of HA-IK and Flag-USP47 were immunoprecipitated with the anti-USP47 monoclonal antibody."
32377397
sparser
"In contrast, the overexpression of Flag-USP47 decreased the p53 level, and it was also rescued by treatment with MG132 ( xref b)."
32370049
sparser
"Next, to examine whether USP47 directly binds to IK, cell lysates expressing HA-IK and Flag-USP47 were used in a pull-down assay with anti-HA or -Flag antibodies."
32377397
sparser
"Moreover, ectopically overexpressed Flag-USP47 interacted with endogenous RPS2 ( xref )."
32370049
sparser
"To verify the interaction of USP47 and RPS2, we performed immunoprecipitation with anti-Flag agarose after overexpressing HA-RPS2 and Flag-USP47."
32370049
RPS2 binds USP47 and Flag. 1 / 1
| 1
sparser
"Moreover, ectopically overexpressed Flag-USP47 interacted with endogenous RPS2 ( xref )."
32370049
SOX9 affects USP47
| 4 2
SOX9 increases the amount of USP47.
| 3
SOX9 increases the amount of USP47. 3 / 3
| 3
reach
"Sox9 then migrates to the nucleus and upregulates the expression of USP47, which hampers the ubiquitination of Snail, thereby preventing the proteasomal degradation of Snail."
29162839
reach
"Furthermore, the silencing of Sox9 suppressed the expression of USP47 protein and manifestation of EMT."
29162839
reach
"Sox9 induces expression of USP47 by binding to its promoter region under hypoxic conditions."
29162839
SOX9 binds USP47.
| 2
SOX9 binds USP47. 2 / 2
| 2
sparser
"Our data demonstrate that hypoxic exposure of CRC cells significantly increased the expression of Sox9 and that Sox9 binds to the promoter region of USP47 ."
29162839
sparser
"USP47 was transcriptionally activated under hypoxia when the transcription factor SOX-9 binds to the USP47 promoter region at −877 to −831 bp, thus promoting its transcription ( xref )."
34604226
SOX9 activates USP47.
| 1
SOX9 activates USP47. 1 / 1
| 1
reach
"Notably, hypoxia induced USP47 upregulation was mediated by Sox9."
29162839
KCNQ1OT1 affects USP47
| 2 4
KCNQ1OT1 increases the amount of USP47.
| 2
KCNQ1OT1 increases the amount of USP47. 2 / 2
| 2
reach
"Compared with the shNC group, KCNQ1OT1 knockdown significantly downregulated USP47 expression, and miR-454 knockdown significantly reversed shKCNQ1OT1 mediated effects on USP47 expression."
33576460
reach
"Furthermore, compared with the shNC group, KCNQ1OT1 knockdown significantly downregulated USP47 expression, which was significantly counteracted by miR-454 knockdown."
33576460
KCNQ1OT1 activates USP47.
| 2
KCNQ1OT1 activates USP47. 2 / 2
| 2
eidos
"Compared with the shNC group , KCNQ1OT1 knockdown significantly downregulated USP47 expression , and miR-454 knockdown significantly reversed shKCNQ1OT1-mediated effects on USP47 expression ."
33576460
eidos
"Furthermore , compared with the shNC group , KCNQ1OT1 knockdown significantly downregulated USP47 expression , which was significantly counteracted by miR-454 knockdown ."
33576460
KCNQ1OT1 decreases the amount of USP47.
| 1
KCNQ1OT1 decreases the amount of USP47. 1 / 1
| 1
reach
"The RT-qPCR results suggested that USP47 expression was significantly downregulated in KCNQ1OT1-knockdown DDP resistant NPC cells compared with the shNC group, and miR-454 knockdown significantly reversed KCNQ1OT1 knockdown mediated downregulation of USP47 expression levels (XREF_FIG)."
33576460
KCNQ1OT1 binds USP47.
| 1
USP47 binds KCNQ1OT1. 1 / 1
| 1
reach
"The association between miR-454 and KCNQ1OT1 or USP47 was verified via bioinformatics analysis, dual-luciferase reporter assays and RIP assays."
33576460
Flag affects USP47
| 6
USP47 binds Flag. 5 / 5
| 5
sparser
"In addition, cell lysates obtained without the overexpression of HA-IK and Flag-USP47 were immunoprecipitated with the anti-USP47 monoclonal antibody."
32377397
sparser
"In contrast, the overexpression of Flag-USP47 decreased the p53 level, and it was also rescued by treatment with MG132 ( xref b)."
32370049
sparser
"Next, to examine whether USP47 directly binds to IK, cell lysates expressing HA-IK and Flag-USP47 were used in a pull-down assay with anti-HA or -Flag antibodies."
32377397
sparser
"Moreover, ectopically overexpressed Flag-USP47 interacted with endogenous RPS2 ( xref )."
32370049
sparser
"To verify the interaction of USP47 and RPS2, we performed immunoprecipitation with anti-Flag agarose after overexpressing HA-RPS2 and Flag-USP47."
32370049
RPS2 binds USP47 and Flag. 1 / 1
| 1
sparser
"Moreover, ectopically overexpressed Flag-USP47 interacted with endogenous RPS2 ( xref )."
32370049
YBX1 affects USP47
| 2 3
USP47 binds YBX1. 4 / 4
| 1 3
sparser
"The results show that USP47 interacts with the C-terminal domain (CTD) domain of YB-1 (Fig.  xref )."
33397955
sparser
"It was identified that YB-1 can interact with USP47 in K562 and primary CML cells (Fig.  xref )."
33397955
sparser
"Interestingly, the interaction between YB-1 and USP47 is not affected by the ubiquitination status of YB-1, as the mutation of lysine residues (Lys137, −164, and −170) abrogates the ubiquitination of YB-1, but not its interaction with USP47 (Fig.  xref )."
33397955
reach
"Interestingly, the interaction between YB-1 and USP47 is not affected by the ubiquitination status of YB-1, as the mutation of lysine residues (Lys137, -164, and -170) abrogates the ubiquitination of YB-1, but not its interaction with USP47."
33397955
USP47 binds YBX1 and K562. 1 / 1
| 1
reach
"It was identified that YB-1 can interact with USP47 in K562 and primary CML cells."
33397955
USP47 affects Wnt
| 1 3
USP47 activates Wnt. 4 / 5
| 1 3
eidos
"In human cells , knockdown of USP47 inhibited Wnt reporter activity , and USP47 acted downstream of the beta-catenin destruction complex ."
36749823
reach
"In human cells, knockdown of USP47 inhibited Wnt reporter activity, and USP47 acted downstream of the β-catenin destruction complex."
36749823
reach
"The results indicate that USP47 induces a positive process in Wnt and beta-catenin signaling while increasing the stability of beta-catenin [XREF_BIBR, XREF_BIBR]."
32486158
reach
"USP47 also augments Wnt signaling through deubiquitination of beta-catenin in A549 lung and PC3 prostate cancer cells 18."
29162839
USP47 affects Pol beta
| 5
USP47 increases the amount of Pol beta.
| 2
USP47 increases the amount of Pol beta. 2 / 2
| 2
reach
"Collectively, these studies highlight the discovery of an important pathway involved in the regulation of both the cellular steady state level, and the levels in response to DNA damage, of Pol beta wh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23473643
reach
"Interestingly, a simultaneous siRNA knockdown of Mule and USP47 was discovered to be able to restore exogenously expressed Pol beta levels that were reduced by a USP47 siRNA knockdown alone, demonstra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25108137
USP47 inhibits Pol beta.
| 1
USP47 inhibits Pol beta. 1 / 1
| 1
reach
"An siRNA knockdown of USP47 in vivo in HeLa cells was shown to modulate specifically the monoubiquitylated proportion of Pol beta found in the cytoplasm, and caused an increased degradation of newly s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23473643
USP47 deubiquitinates Pol beta.
| 1
USP47 deubiquitinates Pol beta. 1 / 1
| 1
reach
"Intriguingly, we discovered that USP47 was able to deubiquitylate both mono- and polyubiquitylated forms of Pol beta in vitro."
25076968
USP47 decreases the amount of Pol beta.
| 1
USP47 decreases the amount of Pol beta. 1 / 1
| 1
reach
"Knockdown of USP47 decreased the level of Pol beta which defect the BER pathway, leading to accumulation of DNA strand breaks induced by DNA damaging agents [XREF_BIBR]."
28031783
E2F7 affects USP47
| 2 2 1
E2F7 activates USP47.
| 2 1
E2F7 activates USP47. 3 / 3
| 2 1
eidos
"E2F7 upregulated USP47 expression by downregulating miR-199b in SW403 cells ."
33489876
eidos
"USP47 upregulation by E2F7 deubiquitin-modifies MAPK K48 ubiquitin chain to stabilize MAPK ."
33489876
reach
"Therefore, we are convinced that present results show that E2F7 suppressed the miR-199b expression and promoted USP47 to stabilize MAPK proteins, thereby contributing to colon cancer development."
33489876
E2F7 increases the amount of USP47.
| 1
E2F7 increases the amount of USP47. 1 / 1
| 1
reach
"E2F7 upregulated USP47 expression by downregulating miR-199b in SW403 cells."
33489876
E2F7 binds USP47.
| 1
MAPK binds USP47 and E2F7. 1 / 1
| 1
sparser
"The interaction between E2F7, miR-199b, USP47, and MAPK was identified by ChIP-Seq analysis, luciferase reporter, RNA pull-down, co-immunoprecipitation, as well as glutathione-S-transferase (GST) pull-down experiments."
33489876
Parthenolide affects USP47
| 1 1 1 1
Parthenolide inhibits USP47. 3 / 3
| 1 1 1
reach
"USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide."
34030041
eidos
"USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide ."
34030041
sparser
"USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide."
34030041
Parthenolide inhibits USP47. 1 / 1
| 1
trips
"USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide."
34030041
USP47 affects RPL11
| 4
RPL11 binds USP47. 4 / 4
| 4
sparser
"To solve this question, we will investigate whether this lncRNA affects the interaction of USP47 with RPL11 or the deubiquitination and translocation of RPL11 by USP47, and thus is involved in the p53 protein levels as in our models."
35205710
sparser
"To confirm this possibility, we first investigated the interaction between USP47 and RPL11."
35205710
sparser
"When we co-transfected with Flag-tagged USP47 and HA-tagged RPL11 in the cells, and we observed the binding of USP47 to RPL11 by immunoprecipitation with anti-Flag magnetic beads ( xref a)."
35205710
sparser
"In addition, USP47 binds to and deubiquitinates RPL11, and USP47-induced RPL11 deubiquitination is inhibited by miR-101-3p."
35205710
USP47 affects BCR-ABL
| 4
USP47 activates BCR-ABL. 3 / 3
| 3
reach
"USP47 knockout significantly inhibited BCR-ABL and BCR-ABL -induced mouse CML with reduced of LIN Sca1 c-kit CML stem cells/progenitor cells."
34604226
reach
"The knockout of Usp47 significantly inhibits BCR-ABL and BCR-ABL T315I -induced CML in mice with the reduction of Lin - Sca1 + c-Kit + CML stem and progenitor cells."
33397955
reach
"We show that knockout of Usp47 significantly prevents BCR-ABL or BCR-ABL T315I -induced leukemogenesis and reduces the number of GFP + LSK cells in CML mice, indicating that Usp47 is critical in the development of BCR-ABL-induced CML."
33397955
USP47 activates BCR-ABL-T315I. 1 / 1
| 1
reach
"We show that knockout of Usp47 significantly prevents BCR-ABL or BCR-ABL T315I -induced leukemogenesis and reduces the number of GFP + LSK cells in CML mice, indicating that Usp47 is critical in the development of BCR-ABL-induced CML."
33397955
RPL11 affects USP47
| 4
RPL11 binds USP47. 4 / 4
| 4
sparser
"To solve this question, we will investigate whether this lncRNA affects the interaction of USP47 with RPL11 or the deubiquitination and translocation of RPL11 by USP47, and thus is involved in the p53 protein levels as in our models."
35205710
sparser
"To confirm this possibility, we first investigated the interaction between USP47 and RPL11."
35205710
sparser
"When we co-transfected with Flag-tagged USP47 and HA-tagged RPL11 in the cells, and we observed the binding of USP47 to RPL11 by immunoprecipitation with anti-Flag magnetic beads ( xref a)."
35205710
sparser
"In addition, USP47 binds to and deubiquitinates RPL11, and USP47-induced RPL11 deubiquitination is inhibited by miR-101-3p."
35205710
USP47 is modified
| 1 3
USP47 is ubiquitinated. 4 / 4
| 1 3
sparser
"This statement is based on the following evidences: (i) USP47 is a stable protein, with a half-life of over 8 h; (ii) proteasome activity does not regulate USP47 protein levels; (iii) silencing of β-Trcp does not induce stabilization of USP47; (iv) USP47 expression is constant during a variety of processes, such as cell-cycle progression, DNA damage checkpoint responses or TNF signaling; and (v) SCF β-Trcp is not able to mediate USP47 ubiquitylation in vitro ."
19966869
sparser
"Furthermore, USP47 deubiquitinates itself, whereas β-TrCP promotes USP47 ubiquitination through interaction with an atypical motif in USP47."
26169834
trips
"Furthermore, USP47 deubiquitinates itself, whereas β-TrCP promotes USP47 ubiquitination through interaction with an atypical motif in USP47."
26169834
sparser
"Finally, attempts to ubiquitylate USP47 in the presence of purified SCF β-Trcp , E1 and several E2s (UbcH5 and UbcH3) had negative results (data not shown)."
19966869
Nigericin affects USP47
| 2 1
Nigericin inhibits USP47.
| 1
Nigericin inhibits USP47. 1 / 1
| 1
reach
"At the concentration used in this experiment, we observed that P22077 did not cause a complete inhibition of the nigericin induced increase in activity of USP7 and USP47 that may be due to the irreversible action of the ABP versus the reversible inhibitor 24."
30206189
Nigericin increases the amount of USP47.
| 1
Nigericin increases the amount of USP47. 1 / 1
| 1
reach
"Although LPS treatment did not induce any differences in either protein level and activity of USP47, nigericin increased both the USP47 level and activity, and an unknown post-translational modification of USP47 may contribute to the modulation induced by nigericin (Palazón-Riquelme et al., 2018)."
34604226
Nigericin activates USP47.
| 1
Nigericin activates USP47. 1 / 1
| 1
sparser
"Nigericin‐induced activation of both USP7 and USP47 was not dependent on LPS priming (Fig xref A, final lane)."
30206189
MiR-454 affects USP47
| 3
MiR-454 activates USP47.
| 2
MiR-454 activates USP47. 2 / 2
| 2
reach
"Furthermore, the results indicated that miR-454 directly targeted USP47."
33576460
reach
"USP47 is directly targeted by miR-454."
33576460
MiR-454 binds USP47.
| 1
USP47 binds miR-454. 1 / 1
| 1
reach
"The association between miR-454 and KCNQ1OT1 or USP47 was verified via bioinformatics analysis, dual-luciferase reporter assays and RIP assays."
33576460
MiR-101-3p affects USP47
| 1 1 1
MiR-101-3p inhibits USP47.
| 1
MiR-101-3p inhibits USP47. 1 / 1
| 1
eidos
"We confirm that miR-101-3p directly binds to the 3 ' - UTR region of the USP47 gene and inhibits USP47 expression ."
35205710
MiR-101-3p increases the amount of USP47.
| 1
MiR-101-3p increases the amount of USP47. 1 / 1
| 1
isi
"Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression."
32379981
MiR-101-3p decreases the amount of USP47.
| 1
MiR-101-3p decreases the amount of USP47. 1 / 1
| 1
reach
"We confirm that miR-101-3p directly binds to the 3'-UTR region of the USP47 gene and inhibits USP47 expression."
35205710
Bisphenol A affects USP47
3 |
Bisphenol A increases the amount of USP47. 3 / 3
3 |
ctd
No evidence text available
26063408
ctd
No evidence text available
30816183
ctd
No evidence text available
25181051
ZNF883 affects USP47
| 3
ZNF883 inhibits USP47.
| 1
ZNF883 inhibits USP47. 1 / 1
| 1
reach
"ZNF883 targeted miR-138-5p and miR-138-5p negatively regulated USP47."
35678979
ZNF883 increases the amount of USP47.
| 1
ZNF883 increases the amount of USP47. 1 / 1
| 1
reach
"ZNF883 overexpression in epileptic neurons elevated USP47 expression."
35678979
ZNF883 activates USP47.
| 1
ZNF883 activates USP47. 1 / 1
| 1
reach
"ZNF883 silencing in EP rats decreased USP47 and NLRP3, increased miR-138-5p, and inhibited inflammation and apoptosis."
35678979
Ubiquitin affects USP47
| 2 1
Ubiquitin inhibits USP47.
| 2
Ubiquitin inhibits USP47. 2 / 2
| 2
reach
"GSK-3β inactivated by its upstream Akt and ubiquitin-specific protease 47 (USP47) has been shown to inhibit β-catenin degradation."
36813838
reach
"It has been reported that P22077, a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, inhibited the proliferation of HIV virus by inhibiting the function of USP47 [27]."
31982568
Ubiquitin binds USP47.
| 1
sparser
"We employed this assay to conduct a targeted RNAi screen using a focused dsRNA library encompassing factors linked to ubiquitin-proteasome function ( xref ; xref ) that might interact genetically with Usp47 ."
27552662
USP47 affects RPS2-mediated MDM2
| 3
USP47 inhibits RPS2-mediated MDM2. 3 / 3
| 3
eidos
"USP47 inhibits the interaction between RPS2 and MDM2 thereby alleviating RPS2-mediated suppression of MDM2 under normal conditions ."
32370049
eidos
"Taken together , these results suggest that USP47 inhibits the interaction between RPS2 and MDM2 , thereby decreasing RPS2-mediated inhibition of MDM2 under normal conditions ( Figure 2 ; Figure 3 ) ."
32370049
eidos
"USP47 deubiquitinates RPS2 and alleviates RPS2-mediated inhibition of MDM2 ."
32370049
USP47 affects POLB
1 | 2
USP47 deubiquitinates POLB.
1 | 1
USP47 deubiquitinates POLB. 2 / 2
1 | 1
reach
"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
ubibrowser
No evidence text available
USP47 increases the amount of POLB.
| 1
USP47 increases the amount of POLB. 1 / 1
| 1
reach
"For example, we have shown that the E3 ubiquitin ligase Mule, the tumor suppressor protein ARF, and the deubiquitylation enzyme USP47 modulate DNA repair by controlling cellular levels of DNA polymerase beta, and also that polynucleotide kinase phosphatase levels are controlled by ATM-dependant phosphorylation and Cul4A-DDB1-STRAP-dependent ubiquitylation."
25076968
USP47 affects ERAP1
| 1 2
ERAP1 binds USP47. 3 / 3
| 1 2
sparser
"We demonstrate that ERAP1 binds the deubiquitylase enzyme USP47, displaces the USP47-associated βTrCP, the substrate-receptor subunit of the SCF βTrCP ubiquitin ligase, and promotes βTrCP degradation."
31341163
reach
"We demonstrate that ERAP1 binds the deubiquitylase enzyme USP47, displaces the USP47 associated betaTrCP, the substrate-receptor subunit of the SCF betaTrCP ubiquitin ligase, and promotes betaTrCP degradation."
31341163
sparser
"The interaction of the positive HH regulator ERAP1 with USP47 induces the degradation of βTrCP, thus protecting GLIs from βTrCP-dependent degradation and stimulating HH activity [ xref ]."
32531973
USP47 affects Carcinogenesis
| 2 1
USP47 activates Carcinogenesis.
| 2
eidos
"USP47 Promotes Tumorigenesis by Negative Regulation of p53 through Deubiquitinating Ribosomal Protein S2 ."
32370049
eidos
"USP47 Promotes Tumorigenesis by Negative Regulation of p53 through Deubiquitinating Ribosomal Protein S2 p53 is activated in response to cellular stresses such as DNA damage , oxidative stress , and especially ribosomal stress ."
32370049
USP47 inhibits Carcinogenesis.
| 1
reach
"The deficiency of USP47 impaired the transcriptional activity of SATB1 target genes and inhibited cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer."
34604226
SLC4A1 affects USP47
| 1 2
SLC4A1 inhibits USP47.
| 1 1
SLC4A1 inhibits USP47. 2 / 2
| 1 1
reach
"Cells were treated with the following DIs: P22077, which specifically inhibits the DUBs USP7 and USP47 [59], the DI P5091, which only inhibits USP7 [60], and the DI PR-619, that, in addition to USP7 and USP47, inhibits the DUBs Josephin domain containing 2 (JOSD2), deneddylase 1 (DEN1), UCH-L3, UCH-L5, USP2, 4, 5, 8, 15, 20, and 28 [59]."
28805676
eidos
"In this study , we could show that DIs , especially those inhibiting USP7 and USP47 , enhance the entry of Gag into the UPS and thus into the MHC-I pathway , indicating that specific DUBs play an important role in the regulation of Gag ubiquitination ."
28805676
SLC4A1 activates USP47.
| 1
SLC4A1 activates USP47. 1 / 1
| 1
reach
"Cells were treated with the following DIs: P22077, which specifically inhibits the DUBs USP7 and USP47 [59], the DI P5091, which only inhibits USP7 [60], and the DI PR-619, that, in addition to USP7 and USP47, inhibits the DUBs Josephin domain containing 2 (JOSD2), deneddylase 1 (DEN1), UCH-L3, UCH-L5, USP2, 4, 5, 8, 15, 20, and 28 [59]."
28805676
SATB1 affects USP47
| 1 2
SATB1 binds USP47. 2 / 2
| 1 1
sparser
"USP47 interacted with SATB1 through its catalytic core domain and antagonized Smurf2-mediated SATB1 degradation."
34604226
reach
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
SATB1 binds SNAI1 and USP47. 1 / 1
| 1
sparser
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
P5091 affects USP47
| 2 1
P5091 inhibits USP47.
| 2
P5091 inhibits USP47. 2 / 2
| 2
eidos
"Since the previous studies have demonstrated that P5091 also inhibits Usp47 activity , we chose other specific Usp7 inhibitors ( Usp7-IN-155 and HBX-1981856 ) to validate our results ."
30679505
eidos
"Our initial USP7 inhibitor , P5091 , is not specific to USP7 but additionally inhibits USP47 ( ubiquitin-specific peptidase 47 ) , which , among several functions , controls tumor cell proliferation ( 38,39 ) ."
34965932
P5091 activates USP47.
| 1
P5091 activates USP47. 1 / 1
| 1
reach
"Both P02207 and P5091 target USP7 with the added function that P5091 simultaneously targets USP47 directing the cell fate towards apoptosis."
28923280
ERAP1 affects USP47
| 1 2
ERAP1 binds USP47. 3 / 3
| 1 2
sparser
"We demonstrate that ERAP1 binds the deubiquitylase enzyme USP47, displaces the USP47-associated βTrCP, the substrate-receptor subunit of the SCF βTrCP ubiquitin ligase, and promotes βTrCP degradation."
31341163
reach
"We demonstrate that ERAP1 binds the deubiquitylase enzyme USP47, displaces the USP47 associated betaTrCP, the substrate-receptor subunit of the SCF betaTrCP ubiquitin ligase, and promotes betaTrCP degradation."
31341163
sparser
"The interaction of the positive HH regulator ERAP1 with USP47 induces the degradation of βTrCP, thus protecting GLIs from βTrCP-dependent degradation and stimulating HH activity [ xref ]."
32531973
BCR-ABL affects USP47
| 3
BCR-ABL increases the amount of USP47. 2 / 2
| 2
reach
"In contrast, BCR-ABL knockdown or IM treatment attenuates the expression of USP47 at the mRNA and protein levels."
33397955
reach
"Based on the fact that TKI reduces the expression of USP47 in CML cells and overexpression of BCR-ABL upregulates the expression of USP47 in 32D cells, we demonstrate that BCR-ABL upregulates the expression of USP47."
33397955
Modified BCR-ABL increases the amount of USP47. 1 / 1
| 1
reach
"Based on the fact that TKI reduces the expression of USP47 in CML cells and overexpression of BCR-ABL upregulates the expression of USP47 in 32D cells, we demonstrate that BCR-ABL upregulates the expression of USP47."
33397955
Tetrachloromethane methylates USP47.
1 |
ctd
No evidence text available
30690589
Tetrachloromethane decreases the amount of USP47.
1 |
Tetrachloromethane decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
30690589
Phenylmercury acetate decreases the amount of USP47. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Nickel atom affects USP47
2 |
Nickel atom decreases the amount of USP47. 2 / 2
2 |
ctd
No evidence text available
24768652
ctd
No evidence text available
25583101
MiR-454 inhibitor affects USP47
| 2
MiR-454 inhibitor inhibits USP47.
| 1
MiR-454 inhibitor inhibits USP47. 1 / 1
| 1
reach
"Compared with the corresponding NC groups, miR-454 mimics significantly inhibited the luciferase activity of USP47-WT, whereas miR-454 inhibitor significantly increased the luciferase activity of USP47-WT in 5-8F/DDP and SUNE-1 and DDP cells (XREF_FIG)."
33576460
MiR-454 inhibitor increases the amount of USP47.
| 1
MiR-454 inhibitor increases the amount of USP47. 1 / 1
| 1
reach
"Subsequently, the RT-qPCR results demonstrated that miR-454 and USP47 expression levels were significantly decreased in 5-8F/DDP and SUNE-1 and DDP cells following transfection with miR-454 inhibitor or shUSP47 compared with the NC inhibitor and shNC groups, respectively, which suggested that miR-454 inhibitor and shUSP47 downregulated miR-454 and USP47 expression levels in DDP resistant NPC cells, respectively (XREF_FIG)."
33576460
Gag protein affects USP47
| 2
USP47 binds gag protein. 2 / 2
| 2
sparser
"We could show that treatment with DIs targeting USP47 leads to an enhanced polyubiquitination and entry of Gag into the MHC-I pathway, indicating that USP47 somehow interacts with Gag and prevents its entry into the UPS."
28805676
sparser
"Moreover, this study showed that treatment with DUB inhibitors targeting USP47 causes a general Gag processing defect, indicating that USP47 interacts with Gag and prevents its entry into the UPS."
29088112
Entinostat affects USP47
2 |
Entinostat decreases the amount of USP47. 2 / 2
2 |
ctd
No evidence text available
27188386
ctd
No evidence text available
26272509
Cyclosporin A affects USP47
2 |
Cyclosporin A increases the amount of USP47. 2 / 2
2 |
ctd
No evidence text available
20106945
ctd
No evidence text available
25562108
Benzo[a]pyrene affects USP47
2 |
Benzo[a]pyrene decreases the amount of USP47. 2 / 2
2 |
ctd
No evidence text available
20064835
ctd
No evidence text available
26238291
Benzo[a]pyrene diol epoxide I decreases the amount of USP47. 2 / 2
2 |
ctd
No evidence text available
19150397
ctd
No evidence text available
26238291
Aflatoxin B1 affects USP47
2 |
Aflatoxin B1 methylates USP47.
1 |
Aflatoxin B1 methylates USP47. 1 / 1
1 |
ctd
No evidence text available
28458013
Aflatoxin B1 demethylates USP47.
1 |
Aflatoxin B1 demethylates USP47. 1 / 1
1 |
ctd
No evidence text available
27153756
USP47
| 2
USP47 translocates to the adherens junction. 1 / 1
| 1
reach
"Minus end directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions."
25253721
USP47 translocates to the cell junction. 1 / 1
| 1
reach
"KIFC3 recruits USP47 to cell junctions."
25253721
USP47 affects miR-454
| 2
USP47 binds miR-454.
| 1
USP47 binds miR-454. 1 / 1
| 1
reach
"The association between miR-454 and KCNQ1OT1 or USP47 was verified via bioinformatics analysis, dual-luciferase reporter assays and RIP assays."
33576460
USP47 activates miR-454.
| 1
USP47 activates miR-454. 1 / 1
| 1
reach
"The aforementioned results indicated that USP47 was a target of miR-454."
33576460
USP47 affects math-33
| 2
USP47 activates math-33. 2 / 2
| 2
reach
"Furthermore, depletion of these 22 DUBs in math-33 (tm3561) mutants revealed that depletion of T05H10.1, hereafter referred to as USP-47, caused synthetic lethality in the math-33 (tm3561) mutant by increasing embryonic lethality from 35% to 95% (XREF_FIG), and by increasing the lethality of a second probable null math-33 allele, ok2974, from 45% to 93%."
23209443
reach
"We tested whether the major action of MATH-33 and USP-47 was to antagonize poly-ubiquitylation by asking whether compromising protein turnover could suppress the lethality and polarity defects of math-33 (tm3561); usp-47 (RNAi) worms."
23209443
USP47 affects interaction
| 2
USP47 inhibits interaction. 2 / 2
| 2
eidos
"Taken together , these results suggest that USP47 inhibits the interaction between RPS2 and MDM2 , thereby decreasing RPS2-mediated inhibition of MDM2 under normal conditions ( Figure 2 ; Figure 3 ) ."
32370049
eidos
"USP47 inhibits the interaction between RPS2 and MDM2 thereby alleviating RPS2-mediated suppression of MDM2 under normal conditions ."
32370049
USP47 affects gag protein
| 2
USP47 binds gag protein. 2 / 2
| 2
sparser
"We could show that treatment with DIs targeting USP47 leads to an enhanced polyubiquitination and entry of Gag into the MHC-I pathway, indicating that USP47 somehow interacts with Gag and prevents its entry into the UPS."
28805676
sparser
"Moreover, this study showed that treatment with DUB inhibitors targeting USP47 causes a general Gag processing defect, indicating that USP47 interacts with Gag and prevents its entry into the UPS."
29088112
USP47 affects colony
| 2
USP47 activates colony. 2 / 2
| 2
eidos
"By this mechanism , depletion of USP47 inhibits cancer cell growth and colony formation in a p53-dependent manner and it was shown to attenuate tumorigenesis in a xenograft mouse model ."
32370049
eidos
"The depletion of USP47 increased p53 protein level and decreased colony formation , consistent with Figure 6a , c , and increased p53 protein level was decreased by the overexpression of USP47 ( Figure 6e , f ) ."
32370049
USP47 affects cell growth
| 2
USP47 inhibits cell growth.
| 1
USP47 inhibits cell growth. 1 / 1
| 1
reach
"Silencing of USP47 induced a cell growth defect that appeared on day 6 and was sustained through day 9 (XREF_FIG), indicating that depletion of USP47 inhibits cell growth, likely by inducing apoptosis."
19966869
USP47 activates cell growth.
| 1
USP47 activates cell growth. 1 / 1
| 1
reach
"Silencing of USP47 induced a cell growth defect that appeared on day 6 and was sustained through day 9 (XREF_FIG), indicating that depletion of USP47 inhibits cell growth, likely by inducing apoptosis."
19966869
USP47 affects cell death
| 2
USP47 activates cell death. 2 / 2
| 2
reach
"As shown in XREF_FIG, the genetic depletion of USP47 in mouse embryonic fibroblasts increased the sensitivity to the ultraviolet induced cell death."
19966869
reach
"The pro apoptotic effect elicited by the silencing of USP47 prompted us to analyze whether depletion of USP47 could increase cell death triggered by anticancer drugs in different tumor cell lines."
19966869
USP47 affects cancer cell growth
| 1
USP47 activates cancer cell growth. 1 / 2
| 1
eidos
"By this mechanism , depletion of USP47 inhibits cancer cell growth and colony formation in a p53-dependent manner and it was shown to attenuate tumorigenesis in a xenograft mouse model ."
32370049
USP47 affects amoxicillin
| 2
USP47 decreases the amount of amoxicillin. 1 / 1
| 1
reach
"Furthermore, Usp47 knockout significantly enhances the expression of gammaH 2 AX in GFP + BM cells from BCR-ABL T315I -induced CML mice."
33397955
Modified USP47 decreases the amount of amoxicillin. 1 / 1
| 1
reach
"USP47 overexpression in YB-1 and/or Polbeta depletion cells can not abrogate gammaH 2 AX expression, indicating that YB-1 contributes more to USP47 mediated DNA damage repair than Polbeta in CML cells."
33397955
USP47 affects USP47
| 1 1
USP47 deubiquitinates USP47.
| 1
USP47 deubiquitinates USP47. 1 / 1
| 1
trips
"Furthermore, USP47 deubiquitinates itself, whereas β-TrCP promotes USP47 ubiquitination through interaction with an atypical motif in USP47."
26169834
USP47 decreases the amount of USP47.
| 1
USP47 decreases the amount of USP47. 1 / 1
| 1
reach
"Two alleles of Usp47 (Usp47 Delta1 and Usp47 Delta2) that reduce USP47 protein expression [XREF_BIBR] were found to increase the severity of the rough eye phenotype of rl 1 homozygous flies carrying a hypomorphic allele of mapk (XREF_SUPPLEMENTARY)."
27552662
USP47 affects UBXN1
2 |
UBXN1 binds USP47. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP47 affects TIMM8A
| 2
USP47 activates TIMM8A. 2 / 2
| 2
reach
"Compared with the shNC group, USP47 knockdown significantly suppressed NPC cell viability and DDP resistance, which was significantly reversed by co-transfection with miR-454 inhibitor."
33576460
reach
"In the present study, USP47 was identified as a target of miR-454, and USP47 knockdown significantly inhibited cell viability and DDP resistance in NPC cells compared with the shNC group."
33576460
USP47 affects TCEA3
| 1 1
USP47 binds TCEA3.
| 1
TCEA3 binds USP47. 1 / 1
| 1
sparser
"These results indicated that the USP47-TCEA3 axis modulates cell pyroptosis and apoptosis and may serve as a target for therapeutic intervention in CRC."
34630087
USP47 activates TCEA3.
| 1
USP47 activates TCEA3. 1 / 1
| 1
reach
"While ectopic expression of USP47 increased cellular TCEA3 and resistance to doxorubicin, the effect was markedly attenuated by TCEA3 knockdown."
34630087
USP47 affects STN1
2 |
USP47 binds STN1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP47 affects SOX9
| 2
SOX9 binds USP47. 2 / 2
| 2
sparser
"Our data demonstrate that hypoxic exposure of CRC cells significantly increased the expression of Sox9 and that Sox9 binds to the promoter region of USP47 ."
29162839
sparser
"USP47 was transcriptionally activated under hypoxia when the transcription factor SOX-9 binds to the USP47 promoter region at −877 to −831 bp, thus promoting its transcription ( xref )."
34604226
USP47 affects SMURF2
| 2
USP47 inhibits SMURF2.
| 1
USP47 inhibits SMURF2. 1 / 1
| 1
reach
"SMURF2 is negatively regulated by USP47, and USP47 depletion sensitizes colon cancer cells to 5-FU treatment induced apoptosis."
30742943
USP47 binds SMURF2.
| 1
SMURF2 binds USP47. 1 / 1
| 1
reach
"USP47 interacted with SATB1 through its catalytic core domain and antagonized Smurf2-mediated SATB1 degradation."
34604226
USP47 affects RP23-198C2.1
2 |
USP47 binds RP23-198C2.1. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
20360068
USP47 affects POLR2M
2 |
POLR2M binds USP47. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
reach
"Overexpression of USP47 enhances invasiveness and metastatic potential of CRC cells."
29162839
reach
"In addition, the USP47 knockdown attenuated the invasiveness of DLD-1 cells."
29162839
USP47 affects NFkappaB
| 1 1
USP47 increases the amount of NFkappaB.
| 1
USP47 increases the amount of NFkappaB. 1 / 1
| 1
isi
"We found that USP47 and NF-kappaB expression was significantly increased in MI, and USP47 was positively correlated with NF-kappaB."
32761659
USP47 activates NFkappaB.
| 1
USP47 activates NFkappaB. 1 / 1
| 1
reach
"Luciferase reporter showed that USP47 promotes NF-kappaB promoter activity."
32761659
USP47 affects MAPK14
2 |
USP47 binds MAPK14. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
USP47 affects KATNA1
2 |
USP47 binds KATNA1. 2 / 2
2 |
biogrid
No evidence text available
23904609
biogrid
No evidence text available
23904609
USP47 affects IK
| 2
USP47 binds IK. 2 / 2
| 2
sparser
"Next, to examine whether USP47 directly binds to IK, cell lysates expressing HA-IK and Flag-USP47 were used in a pull-down assay with anti-HA or -Flag antibodies."
32377397
sparser
"In summary, we found that IK depletion impairs the proper splicing of ATM pre-mRNA at exons 1–2, which results in ATM deficiency followed by chromosome fragmentation and that USP47 directly binds to IK and deubiquitinates it leading to its stabilization."
32377397
USP47 affects HOGA1
2 |
USP47 binds HOGA1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP47 affects GST
| 2
GST binds USP47. 2 / 2
| 2
sparser
"Next, we examined the direct interaction between USP47 and RPS2 by a Glutathione S-transferase (GST) pull-down assay using the GST-USP47 477–934 protein that includes the ubiquitin-like (UBL) domain, as the UBL domain is known to mediate protein–protein interaction [ xref ]."
32370049
sparser
"RPS2 in the cell lysate ( xref c) and RPS2 translated by in vitro transcription/translation (IVT/T) ( xref d) both bound to GST-USP47 477-934 ."
32370049
USP47 affects DDI1
2 |
DDI1 binds USP47. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP47 affects BCR
| 2
USP47 inhibits BCR.
| 1
USP47 inhibits BCR. 1 / 1
| 1
reach
"Downregulation of USP47 inhibited the proliferation of imatinib-sensitive or drug-resistant CML cells."
34604226
USP47 activates BCR.
| 1
USP47 activates BCR. 1 / 1
| 1
reach
"USP47 knockout significantly inhibited BCR-ABL and BCR-ABL -induced mouse CML with reduced of LIN Sca1 c-kit CML stem cells/progenitor cells."
34604226
USP47 affects AURKA
2 |
AURKA binds USP47. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
UBXN1 affects USP47
2 |
UBXN1 binds USP47. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
STN1 affects USP47
2 |
USP47 binds STN1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
RP23-198C2.1 affects USP47
2 |
USP47 binds RP23-198C2.1. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
20360068
POLR2M affects USP47
2 |
POLR2M binds USP47. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
NLRP3 affects USP47
| 1 1
NLRP3 inhibits USP47.
| 1
NLRP3 inhibits USP47. 1 / 1
| 1
reach
"ZNF883 inhibits NLRP3 ubiquitination and promotes EP through upregulating USP47 by sponging miR-138-5p."
35678979
NLRP3 binds USP47.
| 1
USP7 binds NLRP3 and USP47. 1 / 1
| 1
sparser
"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [ xref ]."
33138315
MIR454 affects USP47
| 2
MIR454 activates USP47. 2 / 2
| 2
eidos
"KCNQ1OT1 confers DDP resistance in NPC cells via upregulating USP47 expression by sponging miR-454 Subsequently , the RT-qPCR results demonstrated that miR-454 and USP47 expression levels were significantly decreased in 5-8F / DDP and SUNE-1 / DDP cells following transfection with miR-454 inhibitor or shUSP47 compared with the NC inhibitor and shNC groups , respectively , which suggested that miR-454 inhibitor and shUSP47 downregulated miR-454 and USP47 expression levels in DDP-resistant NPC cells , respectively ( Fig. 6A and B ) ."
33576460
eidos
"Compared with the shNC group , KCNQ1OT1 knockdown significantly downregulated USP47 expression , and miR-454 knockdown significantly reversed shKCNQ1OT1-mediated effects on USP47 expression ."
33576460
MIR199B affects USP47
| 2
MIR199B inhibits USP47. 2 / 2
| 2
eidos
"E2F7 Transcriptionally Inhibits MicroRNA-199b Expression to Promote USP47 , Thereby Enhancing Colon Cancer Tumor Stem Cell Activity and Promoting the Occurrence of Colon Cancer microRNAs ( miRNAs ) can modulate the expression level of genes in a post-transcription manner , which are closely related to growth and metastasis of colon cancer ."
33489876
eidos
"E2F7 Transcriptionally Inhibits MicroRNA-199b Expression to Promote USP47 , Thereby Enhancing Colon Cancer Tumor Stem Cell Activity and Promoting the Occurrence of Colon Cancer ."
33489876
MAPK14 affects USP47
2 |
USP47 binds MAPK14. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
KATNA1 affects USP47
2 |
USP47 binds KATNA1. 2 / 2
2 |
biogrid
No evidence text available
23904609
biogrid
No evidence text available
23904609
IK affects USP47
| 2
USP47 binds IK. 2 / 2
| 2
sparser
"Next, to examine whether USP47 directly binds to IK, cell lysates expressing HA-IK and Flag-USP47 were used in a pull-down assay with anti-HA or -Flag antibodies."
32377397
sparser
"In summary, we found that IK depletion impairs the proper splicing of ATM pre-mRNA at exons 1–2, which results in ATM deficiency followed by chromosome fragmentation and that USP47 directly binds to IK and deubiquitinates it leading to its stabilization."
32377397
HOGA1 affects USP47
2 |
USP47 binds HOGA1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
GST affects USP47
| 2
GST binds USP47. 2 / 2
| 2
sparser
"Next, we examined the direct interaction between USP47 and RPS2 by a Glutathione S-transferase (GST) pull-down assay using the GST-USP47 477–934 protein that includes the ubiquitin-like (UBL) domain, as the UBL domain is known to mediate protein–protein interaction [ xref ]."
32370049
sparser
"RPS2 in the cell lysate ( xref c) and RPS2 translated by in vitro transcription/translation (IVT/T) ( xref d) both bound to GST-USP47 477-934 ."
32370049
DDI1 affects USP47
2 |
DDI1 binds USP47. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
CDH1 affects USP47
| 1 1
CDH1 binds USP47. 2 / 2
| 1 1
reach
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
sparser
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
AURKA affects USP47
2 |
AURKA binds USP47. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
4,4'-diaminodiphenylmethane decreases the amount of USP47. 2 / 2
2 |
ctd
No evidence text available
30723492
ctd
No evidence text available
18648102
reach
"Moreover, in a search for additional factors that act similarly to the newly identified E2/E3 enzymes, we found that KCMF1 (FBgn0037655), a zinc finger containing protein that physically interacts with POE, also antagonized USP47 activity."
27552662
Trichostatin A affects USP47
1 |
Trichostatin A decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
24935251
Titanium dioxide affects USP47
1 |
Titanium dioxide decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
31298478
Succimer affects USP47
1 |
Succimer increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
26378955
Sponging miR-454 affects USP47
| 1
Sponging miR-454 activates USP47. 1 / 1
| 1
eidos
"KCNQ1OT1 confers DDP resistance in NPC cells via upregulating USP47 expression by sponging miR-454 Subsequently , the RT-qPCR results demonstrated that miR-454 and USP47 expression levels were significantly decreased in 5-8F / DDP and SUNE-1 / DDP cells following transfection with miR-454 inhibitor or shUSP47 compared with the NC inhibitor and shNC groups , respectively , which suggested that miR-454 inhibitor and shUSP47 downregulated miR-454 and USP47 expression levels in DDP-resistant NPC cells , respectively ( Fig. 6A and B ) ."
33576460
Sodium arsenate affects USP47
1 |
Sodium arsenate increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
21795629
ShUSP47 affects USP47
| 1
ShUSP47 inhibits USP47. 1 / 1
| 1
eidos
"KCNQ1OT1 confers DDP resistance in NPC cells via upregulating USP47 expression by sponging miR-454 Subsequently , the RT-qPCR results demonstrated that miR-454 and USP47 expression levels were significantly decreased in 5-8F / DDP and SUNE-1 / DDP cells following transfection with miR-454 inhibitor or shUSP47 compared with the NC inhibitor and shNC groups , respectively , which suggested that miR-454 inhibitor and shUSP47 downregulated miR-454 and USP47 expression levels in DDP-resistant NPC cells , respectively ( Fig. 6A and B ) ."
33576460
Selenium atom affects USP47
1 |
Selenium atom decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
19244175
Resveratrol affects USP47
1 |
Resveratrol decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
31298478
Perfluorooctane-1-sulfonic acid decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
27153767
Pentachlorophenol affects USP47
1 |
Pentachlorophenol increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
23892564
Non-coding RNA DSCAM-AS1 affects USP47
| 1
Non-coding RNA DSCAM-AS1 activates USP47. 1 / 1
| 1
eidos
"Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression ."
32379981
Nefazodone affects USP47
1 |
Nefazodone increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
24136188
MiR-204-5p affects USP47
| 1
MiR-204-5p inhibits USP47. 1 / 1
| 1
reach
"Furthermore, another study indicated that miR-204-5p suppressed gastric cancer cell growth by inhibiting RAB22A and USP47 [42]."
33888645
MiR-199b affects USP47
| 1
MiR-199b activates USP47. 1 / 1
| 1
reach
"Taken together, the above evidence indirectly proved the result of the present investigation that USP47 is targeted by miR-199b."
33489876
MiR-199b SW403 cells affects USP47
| 1
MiR-199b SW403 cells inhibits USP47. 1 / 1
| 1
eidos
"E2F7 upregulated USP47 expression by downregulating miR-199b in SW403 cells ."
33489876
Methylmercury chloride decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
28001369
Methamphetamine affects USP47
1 |
Methamphetamine decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
29802913
Magnetite nanoparticle increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
26378955
Jinfukang affects USP47
1 |
Jinfukang decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
27392435
Initial USP7 affects USP47
| 1
Initial USP7 activates USP47. 1 / 1
| 1
eidos
"Our initial USP7 inhibitor , P5091 , is not specific to USP7 but additionally inhibits USP47 ( ubiquitin-specific peptidase 47 ) , which , among several functions , controls tumor cell proliferation ( 38,39 ) ."
34965932
Imidazolide affects USP47
| 1
Imidazolide decreases the amount of USP47. 1 / 1
| 1
reach
"In contrast, BCR-ABL knockdown or IM treatment attenuates the expression of USP47 at the mRNA and protein levels."
33397955
Imatinib affects USP47
| 1
Imatinib decreases the amount of USP47. 1 / 1
| 1
reach
"And imatinib (IM) treatment attenuated the expression of USP47."
34604226
Hsa-miR-98-5p affects USP47
1 |
Hsa-miR-98-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-8066 affects USP47
1 |
Hsa-miR-8066 decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-7112-3p affects USP47
1 |
Hsa-miR-7112-3p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4711-5p affects USP47
1 |
Hsa-miR-4711-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4500 affects USP47
1 |
Hsa-miR-4500 decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4458 affects USP47
1 |
Hsa-miR-4458 decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-34a-5p affects USP47
1 |
Hsa-miR-34a-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21566225
Hsa-miR-218-5p affects USP47
1 |
Hsa-miR-218-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23212916
Hsa-miR-21-5p affects USP47
1 |
Hsa-miR-21-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18591254
Hsa-miR-204-5p affects USP47
1 |
Hsa-miR-204-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
25429829
Hsa-miR-202-3p affects USP47
1 |
Hsa-miR-202-3p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-124-3p affects USP47
1 |
Hsa-miR-124-3p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18668037
Hsa-let-7i-5p affects USP47
1 |
Hsa-let-7i-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-let-7g-5p affects USP47
1 |
Hsa-let-7g-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-let-7f-5p affects USP47
1 |
Hsa-let-7f-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-let-7e-5p affects USP47
1 |
Hsa-let-7e-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-let-7d-5p affects USP47
1 |
Hsa-let-7d-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-let-7c-5p affects USP47
1 |
Hsa-let-7c-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-let-7b-5p affects USP47
1 |
Hsa-let-7b-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hsa-let-7a-5p affects USP47
1 |
Hsa-let-7a-5p decreases the amount of USP47. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27292025
Hexabromocyclododecane decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
29177809
Gag affects USP47
| 1
USP47 binds gag. 1 / 1
| 1
sparser
"We could show that treatment with DIs targeting USP47 leads to an enhanced polyubiquitination and entry of Gag into the MHC-I pathway, indicating that USP47 somehow interacts with Gag and prevents its entry into the UPS."
28805676
Flutamide affects USP47
1 |
Flutamide increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
24136188
Fbxw1 affects CTNNB1
| 1
USP47 binds CTNNB1 and fbxw1. 1 / 1
| 1
sparser
"Importantly, mutation of Arginine 434 to alanine abrogated the binding of β-Trcp with both USP47 and β-catenin ( xref , lane 10), indicating that the β-Trcp-USP47 association is comparable with other β-Trcp-substrate interactions."
19966869
Endosulfan affects USP47
1 |
Endosulfan decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
30090376
Doxorubicin affects USP47
1 |
Doxorubicin increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
25896364
Dorsomorphin affects USP47
1 |
Dorsomorphin decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
27188386
Disodium selenite affects USP47
1 |
Disodium selenite increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
18175754
Dicrotophos affects USP47
1 |
Dicrotophos decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
28302478
Dibutyl phthalate affects USP47
1 |
Dibutyl phthalate increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
21266533
Copper(II) sulfate increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
19549813
Cobalt dichloride affects USP47
1 |
Cobalt dichloride increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
19376846
Cisplatin affects USP47
1 |
Cisplatin decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
27392435
Cadmium atom affects USP47
1 |
Cadmium atom decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
24067728
Butanal affects USP47
1 |
Butanal decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
26079696
Beta-Trcp2 affects USP47
| 1
USP47 binds beta-Trcp2. 1 / 1
| 1
reach
"We found that both beta-Trcp1 and beta-Trcp2 bind specifically to USP47, and point mutations in the beta-Trcp WD-repeat region completely abolished USP47 binding, indicating an E3-substrate-type interaction."
19966869
Beta-Trcp1 affects USP47
| 1
USP47 binds beta-Trcp1. 1 / 1
| 1
reach
"We found that both beta-Trcp1 and beta-Trcp2 bind specifically to USP47, and point mutations in the beta-Trcp WD-repeat region completely abolished USP47 binding, indicating an E3-substrate-type interaction."
19966869
Atrazine affects USP47
1 |
Atrazine decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
25929836
ZWINT affects USP47
| 1
ZWINT binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
ZWILCH affects USP47
| 1
USP47 binds ZWILCH. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
YP_009227205 affects USP47
1 |
USP47 binds YP_009227205. 1 / 1
1 |
virhostnet
No evidence text available
30037810
YBX1 affects K562
| 1
USP47 binds YBX1 and K562. 1 / 1
| 1
reach
"It was identified that YB-1 can interact with USP47 in K562 and primary CML cells."
33397955
XPO1 affects USP47
1 |
XPO1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
26673895
WRAP73 affects USP47
1 |
WRAP73 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
26186194
WDR44 affects USP47
1 |
USP47 binds WDR44. 1 / 1
1 |
biogrid
No evidence text available
22863883
Vitamin E affects USP47
1 |
Vitamin E decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
19244175
Vehicle Emissions affects USP47
1 |
Vehicle Emissions demethylates USP47. 1 / 1
1 |
ctd
No evidence text available
25560391
VRK1 affects USP47
1 |
VRK1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
VAMP3 affects USP47
1 |
VAMP3 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP7 affects SHBG
| 1
SHBG binds USP7 and USP47. 1 / 1
| 1
sparser
"Strikingly, treatment of LPS‐primed MDMs with nigericin induced a dramatic increase in the proportion of ABP‐bound USP7 and USP47 (Fig xref A)."
30206189
USP7 affects NLRP3
| 1
USP7 binds NLRP3 and USP47. 1 / 1
| 1
sparser
"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [ xref ]."
33138315
USP7 inhibitors affects USP47
| 1
USP7 inhibitors inhibits USP47. 1 / 1
| 1
reach
"P22077 and P5091 are less selective USP7 inhibitors, also inhibiting USP10 and USP47 (27,28)."
34965932
USP47 affects β-transducin repeat-containing protein
| 1
USP47 increases the amount of β-transducin repeat-containing protein. 1 / 1
| 1
reach
"USP47 knockdown significantly reduced the expression of β-transducin repeat-containing protein (BTRC), serine/threonine-protein kinase akt-1 (AKT1), Klotho, fibroblast growth factor (FGF23), and matrix Gla protein (MGP) in RASMCs after high-phosphorus treatment."
35509185
USP47 activates viral RNA genome replication. 1 / 1
| 1
reach
"Overexpression of USP47 repressed Sendai virus, poly(I:C) and poly(dA:dT)-induced ISRE and IFN-β activation, along with reduced IFNB1 transcription and enhanced viral replication."
37001379
USP47 affects ubiquitination RPS2
| 1
USP47 inhibits ubiquitination RPS2. 1 / 1
| 1
eidos
"Therefore , the ubiquitination of RPS2 was increased by either USP47 depletion or ribosomal stress ."
32370049
USP47 affects ubiquitinated Pol beta
| 1
USP47 decreases the amount of ubiquitinated Pol beta. 1 / 1
| 1
reach
"It is shown that knockdown of USP47 causes an increased level of ubiquitinated Pol beta, decreased levels of deubiquitinated Pol beta, and a deficiency in BER."
30831436
USP47 affects ubiquitinated MDM2
| 1
USP47 inhibits ubiquitinated MDM2. 1 / 1
| 1
eidos
"Based on these results , we conclude that USP47 leads to a decrease in ubiquitinated MDM2 as a result of RPS2-mediated regulation , not direct deubiquitination ."
32370049
USP47 affects transcriptional
| 1
USP47 inhibits transcriptional. 1 / 1
| 1
eidos
"Therefore , we conclude that USP47 inhibits p53 accumulation and its transcriptional activity in an MDM2-dependent manner ."
32370049
USP47 affects transcriptional target special AT-rich sequence binding protein
| 1
USP47 inhibits transcriptional target special AT-rich sequence binding protein. 1 / 1
| 1
eidos
"In mice modeled with colon cancer , deletion of ubiquitin-specific protease 47 ( USP47 ) can impair the transcriptional activity of the target gene special AT-rich sequence binding protein 1 ( SATB1 ) , thus inhibiting the proliferative and migratory capacities , as well as tumorigenicity of colon cancer cells ( 12 ) ."
33489876
USP47 affects transcriptional p53 downstream
| 1
USP47 inhibits transcriptional p53 downstream. 1 / 1
| 1
eidos
"As expected , USP47 knockdown upregulated the transcriptional level of p53 downstream genes , such as p21 , E2F7 , and GADD45alpha ( Figure 2g ) ."
32370049
USP47 affects stabilization YAP
| 1
USP47 activates stabilization YAP. 1 / 1
| 1
eidos
"USP47 functions as a DUB for YAP in colorectal cancer , USP47 elevation leads to stabilization of YAP and promotes colorectal cancer cell proliferation 48 ."
33613102
USP47 affects specks
| 1
USP47 inhibits specks. 1 / 1
| 1
eidos
"Another study found that pharmacological inhibition of USP7 / USP47 prevented the formation of ASC specks and dramatically decreased both IL-18 and IL-1beta release ."
33627128
USP47 affects snail
| 1
USP47 activates snail. 1 / 1
| 1
reach
"USP47 upregulation in colorectal cancer was shown to prevent the proteasomal degradation of snail, an inhibitor of E-cadherin expression."
| PMC
USP47 deubiquitinates ubiquitinated ribosomal protein S2. 1 / 1
| 1
reach
"We show that ubiquitinated ribosomal protein S2 (RPS2) by Mouse double minute 2 homolog (MDM2) is deubiquitinated by USP47."
32370049
USP47 affects pyroptosis
| 1
USP47 inhibits pyroptosis. 1 / 1
| 1
reach
"In cultured CRC cells, knockdown of USP47 increased pyroptosis and apoptosis induced by chemotherapeutic doxorubicin."
34630087
USP47 affects pyroptosis apoptosis induced chemotherapeutic doxorubicin
| 1
USP47 inhibits pyroptosis apoptosis induced chemotherapeutic doxorubicin. 1 / 1
| 1
eidos
"In cultured CRC cells , knockdown of USP47 increased pyroptosis and apoptosis induced by chemotherapeutic doxorubicin ."
34630087
USP47 affects proteolysis
| 1
USP47 activates proteolysis. 1 / 1
| 1
reach
"MATH-33 and USP-47 antagonize protein degradation."
23209443
USP47 affects proteasomal substrates
| 1
USP47 inhibits proteasomal substrates. 1 / 1
| 1
eidos
"It has been shown previously that USP47 is specific for the cleavage of K48-linked polyubiquitin chains and thus prevents the proteasomal degradation of substrates [ 88 ] ."
28805676
USP47 affects proliferative migratory capacities
| 1
USP47 inhibits proliferative migratory capacities. 1 / 1
| 1
eidos
"In mice modeled with colon cancer , deletion of ubiquitin-specific protease 47 ( USP47 ) can impair the transcriptional activity of the target gene special AT-rich sequence binding protein 1 ( SATB1 ) , thus inhibiting the proliferative and migratory capacities , as well as tumorigenicity of colon cancer cells ( 12 ) ."
33489876
USP47 affects polyQ-induced cell death
| 1
USP47 inhibits polyQ-induced cell death. 1 / 1
| 1
eidos
"We then overexpressed USP47 in the compound eyes of GMR-63Q flies and found that USP47 suppressed polyQ-induced cell death ."
33983927
USP47 affects poly(I:C)
| 1
USP47 inhibits poly(I:C). 1 / 1
| 1
reach
"Overexpression of USP47 repressed Sendai virus, poly(I:C) and poly(dA:dT)-induced ISRE and IFN-β activation, along with reduced IFNB1 transcription and enhanced viral replication."
37001379
USP47 affects p53 protein
| 1
USP47 inhibits p53 protein. 1 / 1
| 1
eidos
"The depletion of USP47 increased p53 protein level and decreased colony formation , consistent with Figure 6a , c , and increased p53 protein level was decreased by the overexpression of USP47 ( Figure 6e , f ) ."
32370049
USP47 affects p53 accumulation
| 1
USP47 inhibits p53 accumulation. 1 / 1
| 1
eidos
"Therefore , we conclude that USP47 inhibits p53 accumulation and its transcriptional activity in an MDM2-dependent manner ."
32370049
USP47 affects nuclear Pol-β protein
| 1
USP47 increases the amount of modified nuclear Pol-β protein. 1 / 1
| 1
reach
"Reduced levels of cytoplasmic Pol-β following USP47 depletion are unable to effectively respond to DNA damage induced by exogenous agents, such as MMS, and are insufficient to elevate the levels of nuclear Pol-β protein required for efficient DNA repair [138]."
23712866
USP47 affects nuclear Pol-b protein
| 1
USP47 increases the amount of modified nuclear Pol-b protein. 1 / 1
| 1
reach
"Reduced levels of cytoplasmic Pol-b following USP47 depletion are unable to effectively respond to DNA damage induced by exogenous agents, such as MMS, and are insufficient to elevate the levels of nuclear Pol-b protein required for efficient DNA repair [138] ."
23712866
USP47 affects nuclear Pol beta
| 1
USP47 activates nuclear Pol beta. 1 / 1
| 1
reach
"Indeed, in primary fibroblasts, USP47 knockdown reduced both cytoplasmic and nuclear Pol beta by 1.5- and 1.8-fold, respectively."
21362556
USP47 affects miR-204-5p
| 1
USP47 activates miR-204-5p. 1 / 1
| 1
reach
"Subsequent mechanistic investigations identified that USP47 and RAB22A are direct functional targets of miR-204-5p in GC."
25429829
USP47 affects miR-188-5p
| 1
USP47 activates miR-188-5p. 1 / 1
| 1
reach
"Furthermore, USP47 was a direct target of miR-188-5p, and overexpression of USP47 attenuated LINC00668 knockdown induced tumor suppressive effects in CRC cells."
31233752
USP47 affects math-33 allele
| 1
USP47 activates math-33 allele. 1 / 1
| 1
reach
"Furthermore, depletion of these 22 DUBs in math-33 (tm3561) mutants revealed that depletion of T05H10.1, hereafter referred to as USP-47, caused synthetic lethality in the math-33 (tm3561) mutant by increasing embryonic lethality from 35% to 95% (XREF_FIG), and by increasing the lethality of a second probable null math-33 allele, ok2974, from 45% to 93%."
23209443
USP47 affects lung prostate cancer cells
| 1
USP47 activates lung prostate cancer cells. 1 / 1
| 1
eidos
"USP47 , which is known to deubiquitylate beta-catenin , thus increasing the proliferation of lung and prostate cancer cells [ 142 ] , was reported to be upregulated under hypoxic conditions [ 143 ] ."
31208103
USP47 affects katanin-p60
| 1
USP47 inhibits katanin-p60. 1 / 1
| 1
reach
"Here we showed that USP47 and C terminus of Hsp70 interacting protein (CHIP) antagonistically regulate the stability of katanin-p60 and thereby axonal growth."
23904609
USP47 affects katanin-p60 32
| 1
USP47 deubiquitinates katanin-p60 32. 1 / 1
| 1
reach
"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
USP47 affects inflammation development inflammatory bowel disease
| 1
USP47 inhibits inflammation development inflammatory bowel disease. 1 / 1
| 1
eidos
"Here , we show that ubiquitin-specific protease 47 ( USP47 ) prevents inflammation development in inflammatory bowel disease ( IBD ) ."
35235149
USP47 affects imatinib
| 1
USP47 inhibits imatinib. 1 / 1
| 1
reach
"Downregulation of USP47 inhibited the proliferation of imatinib-sensitive or drug-resistant CML cells."
34604226
USP47 activates glycolytic process. 1 / 1
| 1
reach
"And the overexpression of USP47 promoted the glycolysis capacity of lung cancer cells."
35141006
USP47 affects gastric cancer growth
| 1
USP47 activates gastric cancer growth. 1 / 1
| 1
eidos
"USP47 promotes gastric cancer growth by regulating RelA ."
31133011
USP47 affects gastric cancer cell
| 1
USP47 activates gastric cancer cell. 1 / 1
| 1
eidos
"For example , USP47 overexpression accelerated ovarian cancer cell development ( 44 ) , whereas USP47 knockdown inhibited gastric cancer cell proliferation ( 45 ) ."
33576460
USP47 affects gastric cancer cell growth
| 1
USP47 activates gastric cancer cell growth. 1 / 1
| 1
eidos
"Furthermore , another study indicated that miR-204-5p suppressed gastric cancer cell growth by inhibiting RAB22A and USP47 [ 42 ] ."
33888645
USP47 affects gag
| 1
USP47 binds gag. 1 / 1
| 1
sparser
"We could show that treatment with DIs targeting USP47 leads to an enhanced polyubiquitination and entry of Gag into the MHC-I pathway, indicating that USP47 somehow interacts with Gag and prevents its entry into the UPS."
28805676
USP47 affects function mutated EZH2
| 1
USP47 activates function mutated EZH2. 1 / 1
| 1
eidos
"Inhibition of USP47 would be anticipated to block the function of mutated EZH2 through induction of EZH2 degradation by promoting its ubiquitination ."
35034955
USP47 affects etoposide
| 1
USP47 inhibits etoposide. 1 / 1
| 1
reach
"USP47 knockdown promoted drug sensitivity in the camptothecin (CPT)- and etoposide (Eto)-resistant gastric cell line NCI-N87 rather than AGS, which is sensitive to CPT and Eto (Naghavi et al., 2018)."
34604226
USP47 affects entry UPS
| 1
USP47 inhibits entry UPS. 1 / 1
| 1
eidos
"We could show that treatment with DIs targeting USP47 leads to an enhanced polyubiquitination and entry of Gag into the MHC-I pathway , indicating that USP47 somehow interacts with Gag and prevents its entry into the UPS ."
28805676
USP47 affects doxorubicin
| 1
USP47 activates doxorubicin. 1 / 1
| 1
reach
"While ectopic expression of USP47 increased cellular TCEA3 and resistance to doxorubicin, the effect was markedly attenuated by TCEA3 knockdown."
34630087
USP47 activates developmental process. 1 / 1
| 1
reach
"For example, USP47 overexpression accelerated ovarian cancer cell development, whereas USP47 knockdown inhibited gastric cancer cell proliferation."
33576460
USP47 affects development
| 1
USP47 activates development. 1 / 1
| 1
eidos
"Mechanistic investigations showed that USP47 promoted NSCLC development , which depends a lot on directly binding to and deubiquitination of the basic leucine zipper transcription factor 1 ( BACH1 , BTB and CNC homology 1 ) ."
35141006
USP47 affects cytoplasmic Pol-β
| 1
USP47 increases the amount of cytoplasmic Pol-β. 1 / 1
| 1
reach
"Reduced levels of cytoplasmic Pol-β following USP47 depletion are unable to effectively respond to DNA damage induced by exogenous agents, such as MMS, and are insufficient to elevate the levels of nuclear Pol-β protein required for efficient DNA repair [138]."
23712866
USP47 affects cytoplasmic Pol-beta
| 1
USP47 increases the amount of cytoplasmic Pol-beta. 1 / 1
| 1
reach
"Reduced levels of cytoplasmic Pol-beta following USP47 depletion are unable to effectively respond to DNA damage induced by exogenous agents, such as MMS, and are insufficient to elevate the levels of nuclear Pol-beta protein required for efficient DNA repair [XREF_BIBR]."
23712866
USP47 affects cytoplasmic Pol-b
| 1
USP47 increases the amount of cytoplasmic Pol-b. 1 / 1
| 1
reach
"Reduced levels of cytoplasmic Pol-b following USP47 depletion are unable to effectively respond to DNA damage induced by exogenous agents, such as MMS, and are insufficient to elevate the levels of nuclear Pol-b protein required for efficient DNA repair [138] ."
23712866
USP47 affects cytoplasmic Pol beta
| 1
USP47 increases the amount of cytoplasmic Pol beta. 1 / 1
| 1
reach
"Therefore, the reduced levels of cytoplasmic Pol beta following USP47 knockdown are unable to significantly respond to DNA damage induced by endogenous and exogenous agents and, as we demonstrated, ca[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21362556
USP47 affects colorectal cancer cell
| 1
USP47 activates colorectal cancer cell. 1 / 1
| 1
eidos
"USP47 functions as a DUB for YAP in colorectal cancer , USP47 elevation leads to stabilization of YAP and promotes colorectal cancer cell proliferation 48 ."
33613102
USP47 affects colorectal cancer EMT
| 1
USP47 activates colorectal cancer EMT. 1 / 1
| 1
eidos
"Previous reports indicated that USP47 promotes colorectal cancer EMT and malignancy by stabilizing Snail and activating the Wnt signaling pathway [ 64 ] ."
31133011
USP47 affects cells sensitive resistant
| 1
USP47 activates cells sensitive resistant. 1 / 1
| 1
eidos
"Functional analysis shows that USP47 knockdown represses proliferation of CML cells sensitive or resistant to imatinib in vitro and in vivo ."
33397955
USP47 affects cell
| 1
USP47 activates cell. 1 / 1
| 1
eidos
"Functional experimental results showed that USP47 promoted the cell proliferation in vitro and tumor growth in vivo ."
35141006
USP47 affects cell viability DDP resistance cells
| 1
USP47 activates cell viability DDP resistance cells. 1 / 1
| 1
eidos
"In the present study , USP47 was identified as a target of miR-454 , and USP47 knockdown significantly inhibited cell viability and DDP resistance in NPC cells compared with the shNC group ."
33576460
USP47 affects beta-transducin repeat-containing protein BTRC serine threonine-protein kinase akt-1 AKT1 Klotho fibroblast growth FGF23 matrix protein MGP RASMCs
| 1
USP47 activates beta-transducin repeat-containing protein BTRC serine threonine-protein kinase akt-1 AKT1 Klotho fibroblast growth FGF23 matrix protein MGP RASMCs. 1 / 1
| 1
eidos
"USP47 knockdown significantly reduced the expression of beta-transducin repeat-containing protein ( BTRC ) , serine / threonine-protein kinase akt-1 ( AKT1 ) , Klotho , fibroblast growth factor ( FGF23 ) , and matrix Gla protein ( MGP ) in RASMCs after high-phosphorus treatment ."
35509185
USP47 affects beta-Trcp2
| 1
USP47 binds beta-Trcp2. 1 / 1
| 1
reach
"We found that both beta-Trcp1 and beta-Trcp2 bind specifically to USP47, and point mutations in the beta-Trcp WD-repeat region completely abolished USP47 binding, indicating an E3-substrate-type interaction."
19966869
USP47 affects beta-Trcp1
| 1
USP47 binds beta-Trcp1. 1 / 1
| 1
reach
"We found that both beta-Trcp1 and beta-Trcp2 bind specifically to USP47, and point mutations in the beta-Trcp WD-repeat region completely abolished USP47 binding, indicating an E3-substrate-type interaction."
19966869
USP47 affects beta-Trcp 31
| 1
USP47 deubiquitinates beta-Trcp 31. 1 / 1
| 1
reach
"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
USP47 affects apoptosis myocardial cells
| 1
USP47 activates apoptosis myocardial cells. 1 / 1
| 1
eidos
"USP47 promotes apoptosis in rat myocardial cells after ischemia / reperfusion injury via NF-kappaB activation ."
32761659
USP47 affects apeck-like protein
| 1
USP47 activates apeck-like protein. 1 / 1
| 1
reach
"In addition, inhibition of USP7 and USP47 blocks the NLRP3 inflammasome by preventing apeck-like protein containing a CARD (ASC) oligomerization and speck formation in macrophages [38]."
32650621
USP47 affects activation NF-kappaB signaling pathway
| 1
USP47 inhibits activation NF-kappaB signaling pathway. 1 / 1
| 1
eidos
"Mechanistically , down-regulation of USP47 aggravates the activation of NF-kappaB signaling pathway by increasing the K63-linked poly-ubiquitination of tumor necrosis factor receptor-associated factor 6 ( TRAF6 ) in intestinal epithelial cells ."
35235149
USP47 affects ZWINT
| 1
ZWINT binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects ZWILCH
| 1
USP47 binds ZWILCH. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects ZUP1
| 1
USP47 activates ZUP1. 1 / 1
| 1
reach
"Structures of non-selective DUB inhibitors.Structures of USP1/UAF1 inhibitors.Structures of a representative Novartis USP2 inhibitor and the cathepsin K inhibitor dutacatib.Structures of early USP7 inhibitors from Hybrigenics.USP7 IC50 4.2 μM USP7 IC 50 8.0 μM USP7 IC 50 0.42 μM USP47 IC 50 4.3 μM USP47 IC 50 8.7 μM USP47 IC 50 1.Structures of USP7 inhibitors from Progenra.Structures of recent USP7 inhibitors.Structures of USP8 inhibitors from Hybrigenics.Structures of a USP8 binder and two inhibitors of non-DUB cysteine proteases which advanced to clinical trials."
26852935
USP47 affects YP_009227205
1 |
USP47 binds YP_009227205. 1 / 1
1 |
virhostnet
No evidence text available
30037810
USP47 affects YB-1-S3
| 1
Modified USP47 leads to the deubiquitination of YB-1-S3. 1 / 1
| 1
reach
"XREF_FIG, USP47 overexpression significantly inhibits ubiquitination of full-length YB-1 and YB-1-S3, but not that of the truncated YB-1-S2, which can not bind USP47."
33397955
USP47 affects XPO1
1 |
XPO1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
26673895
USP47 affects WRAP73
1 |
WRAP73 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP47 affects WDR44
1 |
USP47 binds WDR44. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP47 affects VRK1
1 |
VRK1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects VIM
| 1
USP47 decreases the amount of VIM. 1 / 1
| 1
reach
"Knockdown of USP47 suppressed the expression of vimentin and N-cadherin and restored E-cadherin expression under hypoxic conditions."
29162839
USP47 affects VAMP3
1 |
VAMP3 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects Ubiquitin
| 1
sparser
"We employed this assay to conduct a targeted RNAi screen using a focused dsRNA library encompassing factors linked to ubiquitin-proteasome function ( xref ; xref ) that might interact genetically with Usp47 ."
27552662
USP47 affects USP15
| 1
USP15 binds USP47. 1 / 1
| 1
sparser
"Both USP15 and USP47 form a complex with β-catenin leading to its deubiquitination and stabilization ."
28923280
USP47 affects UBA52
| 1
UBA52 binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects TTK
| 1
TTK binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects TRMT2A
1 |
USP47 binds TRMT2A. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects TOMM34
1 |
TOMM34 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects TERF1
| 1
TERF1 binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects TCEA1
1 |
TCEA1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects TBCCD1
1 |
USP47 binds TBCCD1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects SYAP1
1 |
SYAP1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects STUB1
| 1
USP47 inhibits STUB1. 1 / 1
| 1
reach
"USP47 antagonizes CHIP-mediated katanin degradation, therefore controlling axonal growth during neuronal development (Yang et al., 2013)."
34604226
USP47 affects SPATA20
1 |
USP47 binds SPATA20. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects SNX6
1 |
SNX6 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects SNX3
1 |
SNX3 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects SNCA
1 |
SNCA binds USP47. 1 / 1
1 |
biogrid
No evidence text available
17893145
USP47 affects SNAIL
| 1
USP47 deubiquitinates SNAIL. 1 / 1
| 1
reach
"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
USP47 affects SMARCA4
| 1
SMARCA4 binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects SLC8A1
| 1
USP47 activates SLC8A1. 1 / 1
| 1
reach
"Mechanistic investigations showed that USP47 promoted NSCLC development, which depends a lot on directly binding to and deubiquitination of the basic leucine zipper transcription factor 1 (BACH1, BTB and CNC homology 1)."
35141006
USP47 affects SIRT7
1 |
SIRT7 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
22586326
USP47 affects SHBG
| 1
SHBG binds USP7 and USP47. 1 / 1
| 1
sparser
"Strikingly, treatment of LPS‐primed MDMs with nigericin induced a dramatic increase in the proportion of ABP‐bound USP7 and USP47 (Fig xref A)."
30206189
USP47 affects SGO1
| 1
USP47 binds SGO1. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects SF3A3
1 |
SF3A3 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
reach
"Downregulating USP47 reduced myocardial ischemia-reperfusion injury by inhibiting apoptosis (Hu et al., 2020)."
34604226
USP47 affects RUNX1T1
| 1
USP47 inhibits RUNX1T1. 1 / 1
| 1
reach
"USP47 knockdown promoted drug sensitivity in the camptothecin (CPT)- and etoposide (Eto)-resistant gastric cell line NCI-N87 rather than AGS, which is sensitive to CPT and Eto (Naghavi et al., 2018)."
34604226
USP47 affects RPRD1B
1 |
RPRD1B binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects RPRD1A
1 |
USP47 binds RPRD1A. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects RND2
1 |
RND2 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects RHPN1
1 |
RHPN1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects RELA
| 1
USP47 leads to the phosphorylation of RELA. 1 / 1
| 1
reach
"Deubiquitinylase USP47 Promotes RelA Phosphorylation and Survival in Gastric Cancer Cells."
29786670
USP47 affects RECQL
1 |
USP47 binds RECQL. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects RBPJ
1 |
USP47 binds RBPJ. 1 / 1
1 |
biogrid
No evidence text available
25609649
USP47 affects RBM12
1 |
USP47 binds RBM12. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects RAS-MAPK
| 1
USP47 activates RAS-MAPK. 1 / 1
| 1
reach
"USP47 Modulates RAS-MAPK Signaling Downstream of MEK."
27552662
USP47 affects RANBP1
| 1
USP47 binds RANBP1. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects RAD21
1 |
USP47 binds RAD21. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects QRSL1
1 |
USP47 binds QRSL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects Protease
| 1
USP47 inhibits Protease. 1 / 1
| 1
reach
"Structures of non-selective DUB inhibitors.Structures of USP1/UAF1 inhibitors.Structures of a representative Novartis USP2 inhibitor and the cathepsin K inhibitor dutacatib.Structures of early USP7 inhibitors from Hybrigenics.USP7 IC50 4.2 μM USP7 IC 50 8.0 μM USP7 IC 50 0.42 μM USP47 IC 50 4.3 μM USP47 IC 50 8.7 μM USP47 IC 50 1.Structures of USP7 inhibitors from Progenra.Structures of recent USP7 inhibitors.Structures of USP8 inhibitors from Hybrigenics.Structures of a USP8 binder and two inhibitors of non-DUB cysteine proteases which advanced to clinical trials."
26852935
USP47 affects Polβ
| 1
USP47 deubiquitinates Polβ. 1 / 1
| 1
reach
"Parsons et al. (2011) found that USP47 could deubiquitinate Polβ, and USP47 knockdown inhibited the base excised repair pathway and increased hydrogen peroxide-induced DNA damage sensitivity."
34604226
USP47 affects PYCARD
| 1
USP47 activates PYCARD. 1 / 1
| 1
reach
"Another study found that pharmacological inhibition of USP7 and USP47 prevented the formation of ASC specks and dramatically decreased both IL-18 and IL-1beta release."
33627128
USP47 affects PUS1
1 |
PUS1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects PSMD5
1 |
USP47 binds PSMD5. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP47 affects PPP2R5D
1 |
USP47 binds PPP2R5D. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects PPP1R8
1 |
USP47 binds PPP1R8. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects POLL
1 |
USP47 deubiquitinates POLL. 1 / 1
1 |
ubibrowser
"DNA Pol?β?is a component of the BER complex. It is ubiquitinated by Mule and CHIP and is deubiquitinated by USP47?"
25121098
USP47 affects PLS1
1 |
USP47 binds PLS1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects PLA2G2A
1 |
USP47 binds PLA2G2A. 1 / 1
1 |
biogrid
No evidence text available
22118674
USP47 affects PDXDC1
1 |
USP47 binds PDXDC1. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP47 affects PAK2
1 |
USP47 binds PAK2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects P0CK57
1 |
USP47 binds P0CK57. 1 / 1
1 |
virhostnet
No evidence text available
22810586
USP47 affects OTUB1
1 |
USP47 binds OTUB1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects NUP35
1 |
USP47 binds NUP35. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects NTRK1
1 |
USP47 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
USP47 affects NSDHL
1 |
NSDHL binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects NSCLC
| 1
USP47 activates NSCLC. 1 / 1
| 1
reach
"Mechanistic investigations showed that USP47 promoted NSCLC development, which depends a lot on directly binding to and deubiquitination of the basic leucine zipper transcription factor 1 (BACH1, BTB and CNC homology 1)."
35141006
USP47 affects NLRP3 receptor
| 1
USP47 binds NLRP3 receptor. 1 / 1
| 1
reach
"Whether USP7 and USP47 directly interact with NLRP3 receptor or with other inflammasome component was not investigated."
31679183
USP47 activates NLRP3 inflammasome complex assembly. 1 / 1
| 1
reach
"The study showed that treatment with P22077, an inhibitor of both USP7 and USP47, impairs NLRP3 inflammasome activation in macrophages, leading to the inhibition of IL-1β, IL-18, and caspase-1 cleavage and release, as well as pyroptotic cell death."
34604226
USP47 affects NCF2
1 |
USP47 binds NCF2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects NARS1
1 |
USP47 binds NARS1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects NAA15
1 |
USP47 binds NAA15. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 inhibits N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal. 1 / 1
| 1
eidos
"As shown in Figure 2a , the depletion of USP47 increased the p53 level but not in the presence of MG132 ."
32370049
USP47 affects Multiple Myeloma
| 1
USP47 inhibits Multiple Myeloma. 1 / 1
| 1
reach
"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
33643919
USP47 affects MYC
| 1
USP47 binds MYC. 1 / 1
| 1
sparser
"To clarify the effect of USP47 on the p53 level, we ectopically overexpressed the increasing amounts of Myc-USP47."
32370049
USP47 affects MMUT
| 1
USP47 binds MMUT. 1 / 1
| 1
sparser
"Dual luciferase reporter gene assay further implicated a weakened USP47-Wt luciferase activity and did not affect luciferase activity of USP47-Mut ( p > 0.05) in SW403 cells after miR-199b mimic treatment ( xref )."
33489876
USP47 affects MEK
| 1
USP47 activates MEK. 1 / 1
| 1
reach
"USP47 Modulates RAS-MAPK Signaling Downstream of MEK."
27552662
USP47 affects MED9
1 |
USP47 binds MED9. 1 / 1
1 |
hprd
No evidence text available
14638676
USP47 affects MED29
1 |
USP47 binds MED29. 1 / 1
1 |
hprd
No evidence text available
14576168
USP47 affects MDC1
1 |
USP47 binds MDC1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects MCTS1
1 |
USP47 binds MCTS1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects LYPLA1
1 |
USP47 binds LYPLA1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects LSK
| 1
USP47 activates LSK. 1 / 1
| 1
reach
"We show that knockout of Usp47 significantly prevents BCR-ABL or BCR-ABL T315I -induced leukemogenesis and reduces the number of GFP + LSK cells in CML mice, indicating that Usp47 is critical in the development of BCR-ABL-induced CML."
33397955
USP47 affects LRRC40
1 |
USP47 binds LRRC40. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects LIG1
| 1
USP47 binds LIG1. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects LETM1
1 |
USP47 binds LETM1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects KIF23
| 1
USP47 binds KIF23. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects KIF22
1 |
USP47 binds KIF22. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects KCNQ1OT1
| 1
USP47 binds KCNQ1OT1. 1 / 1
| 1
reach
"The association between miR-454 and KCNQ1OT1 or USP47 was verified via bioinformatics analysis, dual-luciferase reporter assays and RIP assays."
33576460
USP47 affects KBM
| 1
USP47 activates KBM-T315I. 1 / 1
| 1
reach
"Silencing Usp47 inhibits BCR-ABL T315I -induced CML and proliferation of KBM T315I in a xenograft mouse model."
33397955
USP47 affects K562
| 1
USP47 binds YBX1 and K562. 1 / 1
| 1
reach
"It was identified that YB-1 can interact with USP47 in K562 and primary CML cells."
33397955
USP47 affects JAG1
| 1
USP47 inhibits JAG1. 1 / 1
| 1
reach
"USP47 knockdown promoted drug sensitivity in the camptothecin (CPT)- and etoposide (Eto)-resistant gastric cell line NCI-N87 rather than AGS, which is sensitive to CPT and Eto (Naghavi et al., 2018)."
34604226
USP47 affects Interferon
| 1
USP47 inhibits Interferon. 1 / 1
| 1
reach
"Deubiquitinase USP47 attenuates virus-induced type I interferon signaling."
37001379
USP47 affects Infections
| 1
USP47 inhibits Infections. 1 / 1
| 1
reach
"P22077 and PR-619 are specific inhibitors of USP7 and USP47, which inhibit Gag processing and reduce the release ofinfectious virions in HIV-1 infection [60]."
34803084
USP47 affects IST1
1 |
USP47 binds IST1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects ISRE
| 1
USP47 inhibits ISRE. 1 / 1
| 1
reach
"Overexpression of USP47 repressed Sendai virus, poly(I:C) and poly(dA:dT)-induced ISRE and IFN-β activation, along with reduced IFNB1 transcription and enhanced viral replication."
37001379
USP47 affects INPP5K
1 |
USP47 binds INPP5K. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects IL-18 IL-1beta release
| 1
USP47 inhibits IL-18 IL-1beta release. 1 / 1
| 1
eidos
"Another study found that pharmacological inhibition of USP7 / USP47 prevented the formation of ASC specks and dramatically decreased both IL-18 and IL-1beta release ."
33627128
USP47 affects IFNB1
| 1
USP47 inhibits IFNB1. 1 / 1
| 1
reach
"Overexpression of USP47 repressed Sendai virus, poly(I:C) and poly(dA:dT)-induced ISRE and IFN-β activation, along with reduced IFNB1 transcription and enhanced viral replication."
37001379
USP47 affects Hh Gli
| 1
USP47 inhibits Hh Gli. 1 / 1
| 1
eidos
"These results also provide convincing evidence that USP47 impairs Hh / Gli signaling and the Hh-driven tumorigenesis ."
31341163
USP47 affects Hedgehog
| 1
USP47 inhibits Hedgehog. 1 / 1
| 1
eidos
"We demonstrated that ERAP1 enhances Hh activity by sequestering USP47 and promoting ubiquitylation and degradation of betaTrCP ."
31341163
USP47 affects HMGN5
1 |
USP47 binds HMGN5. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects HGF-MET
| 1
USP47 activates HGF-MET. 1 / 1
| 1
reach
"Furthermore, USP47 knockdown inhibited the migration of A549 cells by blocking the HGF-MET signal pathway (Buus et al., 2009)."
34604226
USP47 affects HELLS
1 |
USP47 binds HELLS. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects HDLBP
1 |
USP47 binds HDLBP. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects HDAC6
1 |
HDAC6 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
23752268
USP47 affects Groucho/TLE
| 1
USP47 deubiquitinates Groucho/TLE. 1 / 1
| 1
reach
"USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling."
36749823
USP47 affects GRK5
1 |
USP47 binds GRK5. 1 / 1
1 |
biogrid
No evidence text available
22952844
USP47 affects GMPPB
1 |
USP47 binds GMPPB. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP47 affects GAG processing
| 1
USP47 inhibits GAG processing. 1 / 1
| 1
eidos
"However , recently , Setz et al. could show that ubiquitin carboxyl-terminal hydrolases 7 ( USP7 ) - and 47 ( USP47 ) - specific inhibitors P22077 and PR-619 are able to impair GAG processing and affect infectivity of released HIV virions , underscoring the importance of DUBs in HIV biology ( Setz et al ., 2017 ) ."
30254620
USP47 affects Flag-Pol beta
| 1
USP47 decreases the amount of Flag-Pol beta. 1 / 1
| 1
reach
"As predicted, a double knockdown of both USP47 and Mule restored the cellular level of Flag-Pol beta."
21362556
USP47 affects FOXK2
1 |
USP47 binds FOXK2. 1 / 1
1 |
biogrid
No evidence text available
25609649
USP47 affects FOXK1
1 |
USP47 binds FOXK1. 1 / 1
1 |
biogrid
No evidence text available
25609649
USP47 affects FEN1
1 |
USP47 binds FEN1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects FARSB
1 |
FARSB binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects ETF1
1 |
USP47 binds ETF1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects EEF1A2
1 |
USP47 binds EEF1A2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects EEA1
1 |
USP47 binds EEA1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects E3_Ub_ligase
| 1
E3_Ub_ligase binds USP47. 1 / 1
| 1
reach
"26 It was recently reported that USP47 interacts with the E3 ubiquitin ligase, Skp1/Cul1/F-box protein beta-transducin repeat containing protein (SCFbeta -Trcp), 27 and regulates the steady-state levels of DNA polymerase-beta."
23949218
USP47 affects E2F7
| 1
MAPK binds USP47 and E2F7. 1 / 1
| 1
sparser
"The interaction between E2F7, miR-199b, USP47, and MAPK was identified by ChIP-Seq analysis, luciferase reporter, RNA pull-down, co-immunoprecipitation, as well as glutathione-S-transferase (GST) pull-down experiments."
33489876
USP47 affects DNAJC2
1 |
DNAJC2 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects DNA repair
| 1
USP47 activates DNA repair. 1 / 1
| 1
reach
"USP47 overexpression, as well as underexpression, can lead to an increase of mutations and deficiency of DNA repair (120)."
34391779
USP47 inhibits DNA damage checkpoint. 1 / 1
| 1
reach
"As expected, overexpressing YB-1 attenuates DNA damage response induced by USP47 knockdown, as evidenced by the decrease of gammaH 2 AX expression and the number of AP sites."
33397955
USP47 affects DLG1
| 1
USP47 binds DLG1. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects DENR
1 |
USP47 binds DENR. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects DDP resistance
| 1
USP47 activates DDP resistance. 1 / 1
| 1
eidos
"Compared with the shNC group , USP47 knockdown significantly suppressed NPC cell viability and DDP resistance , which was significantly reversed by co-transfection with miR-454 inhibitor ."
33576460
USP47 affects DCT
| 1
USP47 inhibits DCT. 1 / 1
| 1
reach
"Overexpression of USP47 repressed Sendai virus, poly(I:C) and poly(dA:dT)-induced ISRE and IFN-β activation, along with reduced IFNB1 transcription and enhanced viral replication."
37001379
USP47 activates Carcinoma, Squamous Cell. 1 / 1
| 1
reach
"Ubiquitin specific peptidase 47 promotes proliferation of lung squamous cell carcinoma."
35254655
USP47 affects Cancer Cell Growth
| 1
USP47 activates Cancer Cell Growth. 1 / 1
| 1
eidos
"Suppression of USP47 Inhibits Cancer Cell Growth It has been shown that p53 regulates many of the cellular pathways such as inhibition of cell cycle progression , cell proliferation , and induction of apoptosis ."
32370049
USP47 affects CYB5R3
1 |
USP47 binds CYB5R3. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects CXXC1
| 1
SNAI1 binds USP47 and CXXC1. 1 / 1
| 1
sparser
"It would be worthwhile determining whether USP47 can bind to Snail at the SNAG or zinc finger domains and whether such interaction contributes to stabilization of its substarte Snail."
29162839
USP47 affects CTNNBL1
1 |
CTNNBL1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects CRC
| 1
USP47 activates CRC. 1 / 1
| 1
reach
"Another study found that USP47 promoted CRC development by maintaining the stemness of CRC stem cells (Zhang et al., 2021)."
34604226
USP47 affects CNOT7
| 1
CNOT7 binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects CLPP
1 |
USP47 binds CLPP. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects CENPJ
| 1
CENPJ binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects CENPF
| 1
CENPF binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
USP47 affects CDH2
| 1
USP47 decreases the amount of CDH2. 1 / 1
| 1
reach
"Knockdown of USP47 suppressed the expression of vimentin and N-cadherin and restored E-cadherin expression under hypoxic conditions."
29162839
USP47 affects BTB
| 1
USP47 activates BTB. 1 / 1
| 1
reach
"Mechanistic investigations showed that USP47 promoted NSCLC development, which depends a lot on directly binding to and deubiquitination of the basic leucine zipper transcription factor 1 (BACH1, BTB and CNC homology 1)."
35141006
USP47 affects BIRC5
| 1
USP47 activates BIRC5. 1 / 1
| 1
reach
"Downregulation of USP47 decreased apoptosis induced by ischemia/reperfusion injury, increased survivin and cytoplasmic NF-κB, and decreased cleaved caspase-3 and nuclear NF-κB. NF-κB inhibitors could effectively inhibit USP47-induced apoptosis, increase cytoplasmic NF-κB, and decrease nuclear NF-κB. Luciferase reporter genes showed that USP47 promoted NF-κB promoter activity."
34604226
USP47 affects BACH1
| 1
USP47 activates BACH1. 1 / 1
| 1
reach
"Mechanistic investigations showed that USP47 promoted NSCLC development, which depends a lot on directly binding to and deubiquitination of the basic leucine zipper transcription factor 1 (BACH1, BTB and CNC homology 1)."
35141006
USP47 affects AVIL
1 |
AVIL binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects ATP6V1H
1 |
ATP6V1H binds USP47. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP47 affects ATOH1
1 |
USP47 binds ATOH1. 1 / 1
1 |
biogrid
No evidence text available
27542412
USP47 affects ASTE1
1 |
USP47 binds ASTE1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects AP4M1
1 |
USP47 binds AP4M1. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP47 affects ADSL
1 |
USP47 binds ADSL. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP47 affects 2'-deoxyadenosine
| 1
USP47 inhibits 2'-deoxyadenosine. 1 / 1
| 1
reach
"Overexpression of USP47 repressed Sendai virus, poly(I:C) and poly(dA:dT)-induced ISRE and IFN-β activation, along with reduced IFNB1 transcription and enhanced viral replication."
37001379
USP15 affects USP47
| 1
USP15 binds USP47. 1 / 1
| 1
sparser
"Both USP15 and USP47 form a complex with β-catenin leading to its deubiquitination and stabilization ."
28923280
USP14-3 affects USP47
| 1
USP14-3 activates USP47. 1 / 1
| 1
reach
"Inhibition of deubiquitinating activity by USP14 aptamers was specific to USP14, with the USP14-3 aptamer failing to inhibit the DUB activity of UCHL3, USP47, USP5, and UCHL5 and UCH37 (XREF_FIG)."
26041011
UBA52 affects USP47
| 1
UBA52 binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
TTK affects USP47
| 1
TTK binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
TRMT2A affects USP47
1 |
USP47 binds TRMT2A. 1 / 1
1 |
biogrid
No evidence text available
28514442
TOMM34 affects USP47
1 |
TOMM34 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
TNF affects USP47
| 1
TNF activates USP47. 1 / 1
| 1
reach
"Finally, we analyzed the expression of USP47 in HeLa cells treated with TNF-alpha, a stimulus triggering the beta-Trcp-dependent degradation of IkappaBalpha."
19966869
TKI affects USP47
| 1
TKI decreases the amount of USP47. 1 / 1
| 1
reach
"Based on the fact that TKI reduces the expression of USP47 in CML cells and overexpression of BCR-ABL upregulates the expression of USP47 in 32D cells, we demonstrate that BCR-ABL upregulates the expression of USP47."
33397955
TERF1 affects USP47
| 1
TERF1 binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
TCEA3 affects USP47
| 1
TCEA3 binds USP47. 1 / 1
| 1
sparser
"These results indicated that the USP47-TCEA3 axis modulates cell pyroptosis and apoptosis and may serve as a target for therapeutic intervention in CRC."
34630087
TCEA1 affects USP47
1 |
TCEA1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
TBP affects USP47
1 |
TBP decreases the amount of USP47. 1 / 1
1 |
biopax:msigdb
No evidence text available
TBCCD1 affects USP47
1 |
USP47 binds TBCCD1. 1 / 1
1 |
biogrid
No evidence text available
28514442
SYAP1 affects USP47
1 |
SYAP1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAT5 affects USP47
| 1
STAT5 activates USP47. 1 / 1
| 1
reach
"In addition, the RAS or ERK inhibition and STAT5 silencing could also downregulate the BCR-ABL-induced upregulation of USP47 in CML (Lei et al., 2021)."
34604226
SPATA20 affects USP47
1 |
USP47 binds SPATA20. 1 / 1
1 |
biogrid
No evidence text available
28514442
SNX6 affects USP47
1 |
SNX6 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
SNX3 affects USP47
1 |
SNX3 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
SNCA affects USP47
1 |
SNCA binds USP47. 1 / 1
1 |
biogrid
No evidence text available
17893145
SNAI1 affects SATB1
| 1
SATB1 binds SNAI1 and USP47. 1 / 1
| 1
sparser
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
SNAI1 affects CXXC1
| 1
SNAI1 binds USP47 and CXXC1. 1 / 1
| 1
sparser
"It would be worthwhile determining whether USP47 can bind to Snail at the SNAG or zinc finger domains and whether such interaction contributes to stabilization of its substarte Snail."
29162839
SMURF2 affects USP47
| 1
SMURF2 binds USP47. 1 / 1
| 1
reach
"USP47 interacted with SATB1 through its catalytic core domain and antagonized Smurf2-mediated SATB1 degradation."
34604226
SMARCA4 affects USP47
| 1
SMARCA4 binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
SIRT7 affects USP47
1 |
SIRT7 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
22586326
SHBG affects USP7
| 1
SHBG binds USP7 and USP47. 1 / 1
| 1
sparser
"Strikingly, treatment of LPS‐primed MDMs with nigericin induced a dramatic increase in the proportion of ABP‐bound USP7 and USP47 (Fig xref A)."
30206189
SGO1 affects USP47
| 1
USP47 binds SGO1. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
SF3A3 affects USP47
1 |
SF3A3 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
SATB1 affects SNAI1, and USP47
| 1
SATB1 binds SNAI1 and USP47. 1 / 1
| 1
sparser
"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
34604226
RPS2-mediated regulation affects USP47
| 1
RPS2-mediated regulation activates USP47. 1 / 1
| 1
eidos
"Based on these results , we conclude that USP47 leads to a decrease in ubiquitinated MDM2 as a result of RPS2-mediated regulation , not direct deubiquitination ."
32370049
RPS2 affects Flag
| 1
RPS2 binds USP47 and Flag. 1 / 1
| 1
sparser
"Moreover, ectopically overexpressed Flag-USP47 interacted with endogenous RPS2 ( xref )."
32370049
RPRD1B affects USP47
1 |
RPRD1B binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
RPRD1A affects USP47
1 |
USP47 binds RPRD1A. 1 / 1
1 |
biogrid
No evidence text available
28514442
RND2 affects USP47
1 |
RND2 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
RNA DSCAM-AS1 affects USP47
| 1
RNA DSCAM-AS1 activates USP47. 1 / 1
| 1
eidos
"Correction : Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression ."
33779298
RHPN1 affects USP47
1 |
RHPN1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
REGISTERED-NURSE affects USP47
| 1
REGISTERED-NURSE inhibits USP47. 1 / 1
| 1
trips
"Inactivation of USP47 by RNAi increased β-catenin ubiquitination, attenuated Wnt signaling, and repressed cancer cell growth."
26169834
RECQL affects USP47
1 |
USP47 binds RECQL. 1 / 1
1 |
biogrid
No evidence text available
28514442
RBPJ affects USP47
1 |
USP47 binds RBPJ. 1 / 1
1 |
biogrid
No evidence text available
25609649
RBM12 affects USP47
1 |
USP47 binds RBM12. 1 / 1
1 |
biogrid
No evidence text available
28514442
RAS affects USP47
| 1
RAS inhibits USP47. 1 / 1
| 1
reach
"In addition, the RAS or ERK inhibition and STAT5 silencing could also downregulate the BCR-ABL-induced upregulation of USP47 in CML (Lei et al., 2021)."
34604226
RANBP1 affects USP47
| 1
USP47 binds RANBP1. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
RAD21 affects USP47
1 |
USP47 binds RAD21. 1 / 1
1 |
biogrid
No evidence text available
28514442
QRSL1 affects USP47
1 |
USP47 binds QRSL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
Proteasome affects USP47
| 1
Proteasome inhibits USP47. 1 / 1
| 1
reach
"To analyze whether the physical interaction between USP47 and beta-Trcp resulted into a proteasome dependent degradation of USP47, we first analyzed the effect of the proteasome inhibitor MG132 on USP47 protein levels."
19966869
Protease affects USP47
| 1
Protease inhibits USP47. 1 / 1
| 1
reach
"GSK-3β inactivated by its upstream Akt and ubiquitin-specific protease 47 (USP47) has been shown to inhibit β-catenin degradation."
36813838
Plant Extracts affects USP47
1 |
Plant Extracts increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
23557933
PUS1 affects USP47
1 |
PUS1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
PSMD5 affects USP47
1 |
USP47 binds PSMD5. 1 / 1
1 |
biogrid
No evidence text available
26344197
PR-619 affects USP47
| 1
PR-619 inhibits USP47. 1 / 1
| 1
reach
"P22077 and PR-619 are specific inhibitors of USP7 and USP47, which inhibit Gag processing and reduce the release ofinfectious virions in HIV-1 infection [60]."
34803084
PPP2R5D affects USP47
1 |
USP47 binds PPP2R5D. 1 / 1
1 |
biogrid
No evidence text available
28514442
PPP1R8 affects USP47
1 |
USP47 binds PPP1R8. 1 / 1
1 |
biogrid
No evidence text available
28514442
PLS1 affects USP47
1 |
USP47 binds PLS1. 1 / 1
1 |
biogrid
No evidence text available
28514442
PLA2G2A affects USP47
1 |
USP47 binds PLA2G2A. 1 / 1
1 |
biogrid
No evidence text available
22118674
PDXDC1 affects USP47
1 |
USP47 binds PDXDC1. 1 / 1
1 |
biogrid
No evidence text available
22863883
PBX1 affects USP47
1 |
PBX1 decreases the amount of USP47. 1 / 1
1 |
biopax:msigdb
No evidence text available
PAK2 affects USP47
1 |
USP47 binds PAK2. 1 / 1
1 |
biogrid
No evidence text available
28514442
P0CK57 affects USP47
1 |
USP47 binds P0CK57. 1 / 1
1 |
virhostnet
No evidence text available
22810586
OTUB1 affects USP47
1 |
USP47 binds OTUB1. 1 / 1
1 |
biogrid
No evidence text available
28514442
NUP35 affects USP47
1 |
USP47 binds NUP35. 1 / 1
1 |
biogrid
No evidence text available
28514442
NTRK1 affects USP47
1 |
USP47 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NSDHL affects USP47
1 |
NSDHL binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
NLRP3 affects USP7
| 1
USP7 binds NLRP3 and USP47. 1 / 1
| 1
sparser
"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [ xref ]."
33138315
NLRP3 receptor affects USP47
| 1
USP47 binds NLRP3 receptor. 1 / 1
| 1
reach
"Whether USP7 and USP47 directly interact with NLRP3 receptor or with other inflammasome component was not investigated."
31679183
NCF2 affects USP47
1 |
USP47 binds NCF2. 1 / 1
1 |
biogrid
No evidence text available
28514442
NARS1 affects USP47
1 |
USP47 binds NARS1. 1 / 1
1 |
biogrid
No evidence text available
28514442
NAA15 affects USP47
1 |
USP47 binds NAA15. 1 / 1
1 |
biogrid
No evidence text available
28514442
MicroRNA-204-5p affects USP47
| 1
MicroRNA-204-5p inhibits USP47. 1 / 1
| 1
reach
"MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A."
25429829
MicroRNA-199b affects USP47
| 1
MicroRNA-199b inhibits USP47. 1 / 1
| 1
reach
"E2F7 Transcriptionally Inhibits MicroRNA-199b Expression to Promote USP47, Thereby Enhancing Colon Cancer Tumor Stem Cell Activity and Promoting the Occurrence of Colon Cancer."
33489876
MYCBP2 affects USP47
| 1
MYCBP2 decreases the amount of USP47. 1 / 1
| 1
reach
"PAM treatment also induced β-catenin translocation and inhibited β-catenin ubiquitination by activating Akt/GSK-3β signaling and upregulating USP47 expression."
36813838
MYC affects USP47
| 1
USP47 binds MYC. 1 / 1
| 1
sparser
"To clarify the effect of USP47 on the p53 level, we ectopically overexpressed the increasing amounts of Myc-USP47."
32370049
MMUT affects USP47
| 1
USP47 binds MMUT. 1 / 1
| 1
sparser
"Dual luciferase reporter gene assay further implicated a weakened USP47-Wt luciferase activity and did not affect luciferase activity of USP47-Mut ( p > 0.05) in SW403 cells after miR-199b mimic treatment ( xref )."
33489876
MEF2A affects USP47
1 |
MEF2A decreases the amount of USP47. 1 / 1
1 |
biopax:msigdb
No evidence text available
MED9 affects USP47
1 |
USP47 binds MED9. 1 / 1
1 |
hprd
No evidence text available
14638676
MED29 affects USP47
1 |
USP47 binds MED29. 1 / 1
1 |
hprd
No evidence text available
14576168
MDC1 affects USP47
1 |
USP47 binds MDC1. 1 / 1
1 |
biogrid
No evidence text available
28514442
MCTS1 affects USP47
1 |
USP47 binds MCTS1. 1 / 1
1 |
biogrid
No evidence text available
28514442
MAPK affects E2F7
| 1
MAPK binds USP47 and E2F7. 1 / 1
| 1
sparser
"The interaction between E2F7, miR-199b, USP47, and MAPK was identified by ChIP-Seq analysis, luciferase reporter, RNA pull-down, co-immunoprecipitation, as well as glutathione-S-transferase (GST) pull-down experiments."
33489876
MAPK affects CTNNB1
| 1
MAPK binds USP47 and CTNNB1. 1 / 1
| 1
sparser
"Although it has been reported that MAPK or β-catenin interacts with USP47 in Drosophila or tumors xref , xref , USP47 knockdown does not affect the expression of MAPK or β-catenin in CML cells (Supplementary Fig.  xref )."
33397955
Long non-coding RNA DSCAM-AS1 affects USP47
| 1
Long non-coding RNA DSCAM-AS1 increases the amount of USP47. 1 / 1
| 1
reach
"Long non coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression."
32379981
LYPLA1 affects USP47
1 |
USP47 binds LYPLA1. 1 / 1
1 |
biogrid
No evidence text available
28514442
LRRC40 affects USP47
1 |
USP47 binds LRRC40. 1 / 1
1 |
biogrid
No evidence text available
28514442
LIG1 affects USP47
| 1
USP47 binds LIG1. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
LETM1 affects USP47
1 |
USP47 binds LETM1. 1 / 1
1 |
biogrid
No evidence text available
28514442
KITLG affects USP47
| 1
KITLG leads to the ubiquitination of USP47. 1 / 1
| 1
reach
"This statement is based on the following evidences : (i) USP47 is a stable protein, with a half-life of over 8 h; (ii) proteasome activity does not regulate USP47 protein levels; (iii) silencing of beta-Trcp does not induce stabilization of USP47; (iv) USP47 expression is constant during a variety of processes, such as cell-cycle progression, DNA damage checkpoint responses or TNF signaling; and (v) SCF beta-Trcp is not able to mediate USP47 ubiquitylation in vitro."
19966869
KIF23 affects USP47
| 1
USP47 binds KIF23. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
KIF22 affects USP47
1 |
USP47 binds KIF22. 1 / 1
1 |
biogrid
No evidence text available
28514442
KCMF1 affects USP47
| 1
KCMF1 inhibits USP47. 1 / 1
| 1
reach
"Moreover, in a search for additional factors that act similarly to the newly identified E2/E3 enzymes, we found that KCMF1 (FBgn0037655), a zinc finger containing protein that physically interacts with POE, also antagonized USP47 activity."
27552662
K562 affects YBX1
| 1
USP47 binds YBX1 and K562. 1 / 1
| 1
reach
"It was identified that YB-1 can interact with USP47 in K562 and primary CML cells."
33397955
K 7174 affects USP47
1 |
K 7174 increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
24086573
IST1 affects USP47
1 |
USP47 binds IST1. 1 / 1
1 |
biogrid
No evidence text available
28514442
INPP5K affects USP47
1 |
USP47 binds INPP5K. 1 / 1
1 |
biogrid
No evidence text available
28514442
HMGN5 affects USP47
1 |
USP47 binds HMGN5. 1 / 1
1 |
biogrid
No evidence text available
28514442
HIF1A affects USP47
| 1
HIF1A activates USP47. 1 / 1
| 1
eidos
"Choi et al. reported that HIF-1alpha indirectly enhances USP47 expression via SOX9 during hypoxia-induced EMT in colorectal cancer cells [ 172 ] ."
36521737
HELLS affects USP47
1 |
USP47 binds HELLS. 1 / 1
1 |
biogrid
No evidence text available
28514442
HDLBP affects USP47
1 |
USP47 binds HDLBP. 1 / 1
1 |
biogrid
No evidence text available
28514442
HDAC6 affects USP47
1 |
HDAC6 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
23752268
GRK5 affects USP47
1 |
USP47 binds GRK5. 1 / 1
1 |
biogrid
No evidence text available
22952844
GMPPB affects USP47
1 |
USP47 binds GMPPB. 1 / 1
1 |
biogrid
No evidence text available
22863883
GATA1 affects USP47
1 |
GATA1 decreases the amount of USP47. 1 / 1
1 |
biopax:msigdb
No evidence text available
Flag affects RPS2, and USP47
| 1
RPS2 binds USP47 and Flag. 1 / 1
| 1
sparser
"Moreover, ectopically overexpressed Flag-USP47 interacted with endogenous RPS2 ( xref )."
32370049
FOXK2 affects USP47
1 |
USP47 binds FOXK2. 1 / 1
1 |
biogrid
No evidence text available
25609649
FOXK1 affects USP47
1 |
USP47 binds FOXK1. 1 / 1
1 |
biogrid
No evidence text available
25609649
FEN1 affects USP47
1 |
USP47 binds FEN1. 1 / 1
1 |
biogrid
No evidence text available
28514442
FBgn0037655 affects USP47
| 1
FBgn0037655 inhibits USP47. 1 / 1
| 1
reach
"Moreover, in a search for additional factors that act similarly to the newly identified E2/E3 enzymes, we found that KCMF1 (FBgn0037655), a zinc finger containing protein that physically interacts with POE, also antagonized USP47 activity."
27552662
FARSB affects USP47
1 |
FARSB binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
ETF1 affects USP47
1 |
USP47 binds ETF1. 1 / 1
1 |
biogrid
No evidence text available
28514442
ERK affects USP47
| 1
ERK activates USP47. 1 / 1
| 1
reach
"In addition, the RAS or ERK inhibition and STAT5 silencing could also downregulate the BCR-ABL-induced upregulation of USP47 in CML (Lei et al., 2021)."
34604226
EPO affects USP47
| 1
EPO activates USP47. 1 / 1
| 1
reach
"ZNF883 silencing in EP rats decreased USP47 and NLRP3, increased miR-138-5p, and inhibited inflammation and apoptosis."
35678979
EEF1A2 affects USP47
1 |
USP47 binds EEF1A2. 1 / 1
1 |
biogrid
No evidence text available
28514442
EEA1 affects USP47
1 |
USP47 binds EEA1. 1 / 1
1 |
biogrid
No evidence text available
28514442
E3_Ub_ligase affects USP47
| 1
E3_Ub_ligase binds USP47. 1 / 1
| 1
reach
"26 It was recently reported that USP47 interacts with the E3 ubiquitin ligase, Skp1/Cul1/F-box protein beta-transducin repeat containing protein (SCFbeta -Trcp), 27 and regulates the steady-state levels of DNA polymerase-beta."
23949218
E2F7 affects MAPK, and USP47
| 1
MAPK binds USP47 and E2F7. 1 / 1
| 1
sparser
"The interaction between E2F7, miR-199b, USP47, and MAPK was identified by ChIP-Seq analysis, luciferase reporter, RNA pull-down, co-immunoprecipitation, as well as glutathione-S-transferase (GST) pull-down experiments."
33489876
Dietary Fats affects USP47
1 |
Dietary Fats increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
19030233
DUB inhibitors affects USP47
| 1
DUB inhibitors inhibits USP47. 1 / 1
| 1
reach
"Moreover, this study showed that treatment with DUB inhibitors targeting USP47 causes a general Gag processing defect, indicating that USP47 interacts with Gag and prevents its entry into the UPS."
29088112
DUB P22077 affects USP47
| 1
DUB P22077 activates USP47. 1 / 1
| 1
eidos
"A deubiquitination assay with Ub-PLA2 demonstrated that the DUB inhibitor P22077 inhibited USP7 and USP47 , which have high similarity ."
32781716
DNAJC2 affects USP47
1 |
DNAJC2 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
DLG1 affects USP47
| 1
USP47 binds DLG1. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
DENR affects USP47
1 |
USP47 binds DENR. 1 / 1
1 |
biogrid
No evidence text available
28514442
CYB5R3 affects USP47
1 |
USP47 binds CYB5R3. 1 / 1
1 |
biogrid
No evidence text available
28514442
CXXC1 affects USP47
| 1
SNAI1 binds USP47 and CXXC1. 1 / 1
| 1
sparser
"It would be worthwhile determining whether USP47 can bind to Snail at the SNAG or zinc finger domains and whether such interaction contributes to stabilization of its substarte Snail."
29162839
CTNNBL1 affects USP47
1 |
CTNNBL1 binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
CTNNB1 affects fbxw1
| 1
USP47 binds CTNNB1 and fbxw1. 1 / 1
| 1
sparser
"Importantly, mutation of Arginine 434 to alanine abrogated the binding of β-Trcp with both USP47 and β-catenin ( xref , lane 10), indicating that the β-Trcp-USP47 association is comparable with other β-Trcp-substrate interactions."
19966869
CTNNB1 affects MAPK, and USP47
| 1
MAPK binds USP47 and CTNNB1. 1 / 1
| 1
sparser
"Although it has been reported that MAPK or β-catenin interacts with USP47 in Drosophila or tumors xref , xref , USP47 knockdown does not affect the expression of MAPK or β-catenin in CML cells (Supplementary Fig.  xref )."
33397955
CNOT7 affects USP47
| 1
CNOT7 binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
CLPP affects USP47
1 |
USP47 binds CLPP. 1 / 1
1 |
biogrid
No evidence text available
28514442
CENPJ affects USP47
| 1
CENPJ binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
CENPF affects USP47
| 1
CENPF binds USP47. 1 / 1
| 1
reach
"To describe the effect of MTA1 mRNA binding on mitosis regulators, we examined TTK, ZWILCH, DLG1, TERF1, CENPF, CNOT7, SMARCA4, CENPJ, SGO1, ZWINT, LIG1, KIF23, RANBP1, USP47 and UBA52, whose transcripts are bound by MTA1."
| PMC
CCAR1 affects USP47
| 1
CCAR1 activates USP47. 1 / 1
| 1
reach
"We could show that treatment with DIs targeting USP47 leads to an enhanced polyubiquitination and entry of Gag into the MHC-I pathway, indicating that USP47 somehow interacts with Gag and prevents its entry into the UPS."
28805676
Antirheumatic Agents increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
24449571
ctd
No evidence text available
26680231
AVIL affects USP47
1 |
AVIL binds USP47. 1 / 1
1 |
biogrid
No evidence text available
28514442
E3_Ub_ligase binds microtubule-severing ATPase activity, ATPase activity, STUB1, USP47, and FTSH1. 1 / 1
| 1
sparser
"Both USP47 and CHIP, an E3 ubiquitin ligase, competitively bind to katanin’s AAA ATPase domain."
34604226
ATP6V1H affects USP47
1 |
ATP6V1H binds USP47. 1 / 1
1 |
biogrid
No evidence text available
22863883
ATOH1 affects USP47
1 |
USP47 binds ATOH1. 1 / 1
1 |
biogrid
No evidence text available
27542412
ASTE1 affects USP47
1 |
USP47 binds ASTE1. 1 / 1
1 |
biogrid
No evidence text available
28514442
AP4M1 affects USP47
1 |
USP47 binds AP4M1. 1 / 1
1 |
biogrid
No evidence text available
25416956
AKT affects USP47
| 1
AKT inhibits USP47. 1 / 1
| 1
reach
"GSK-3β inactivated by its upstream Akt and ubiquitin-specific protease 47 (USP47) has been shown to inhibit β-catenin degradation."
36813838
ADSL affects USP47
1 |
USP47 binds ADSL. 1 / 1
1 |
biogrid
No evidence text available
28514442
4-hydroxyphenyl retinamide increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
28973697
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
21354282
17alpha-ethynylestradiol decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
23129252
1,3-dinitrobenzene increases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
24140754
1,2-dichloroethane decreases the amount of USP47. 1 / 1
1 |
ctd
No evidence text available
28960355