IndraLab

Statements

USP44 is modified
4 | 31 3
USP44 is methylated.
| 18
USP44 is methylated. 10 / 18
| 18
sparser
"Based on TCGA database and literature search, we analyzed the methylation of KCNA3, USP44, OPLAH and SMTN in esophageal cancer."
32266120
sparser
"We observed a weak agreement in the DNA methylation of of BRCA1 , SLFN11 and USP44 promoter methylation in the primary tumors and corresponding plasma cfDNA in our group of patients with advanced stage HGSOC."
35008168
sparser
"All 16 fallopian tube samples were found negative for MGMT , RASSF10 , SLFN11 and USP44 methylation 0/16 (0.0%), while CST6 methylation was detected in 1/16 (6.3%) and BRCA1 methylation in 4/16 (25.0%) of them."
35008168
sparser
"We further evaluated the prognostic significance of the DNA methylation of BRCA1 , SLFN11 and USP44 in patients in the advanced and metastatic group (group B and C, respectively)."
35008168
sparser
"Our findings indicate that USP44 promoter is methylated in plasma cell-free DNA of metastatic prostate cancer patients and that detection of USP44 promoter methylation is significantly associated with overall survival (OS) ( p = 0.008)."
34572834
sparser
"However, the correlation between USP44 methylation and IBD-associated colorectal cancer was only detected in IBD patients with associated neoplasia, and not in patients with sporadic colorectal cancer [ xref ]."
35145062
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"Evaluation of the Prognostic Significance of the DNA Methylation of BRCA1, SLFN11 and USP44 in HGSOC."
35008168
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"Metastatic stage (group C): In plasma cfDNA, BRCA1 methylation was detected in 10/48 (20.8%), SLFN11 methylation in 7/48 (14.6%) and USP44 methylation in 8/49 (16.3%) ( xref B)"
35008168
sparser
"Sodium bisulfite and decitabine were used for DNA modification and demethylation, and methylation-specific PCR and reverse transcriptase PCR were performed to assess USP44 methylation and expression levels."
32956592
sparser
"DAC treatment substantially decreased USP44 methylation levels but increased USP44 mRNA levels in NPC cells compared with NP69 cells (Fig.  xref )."
35079021
USP44 is phosphorylated.
4 | 5 3
USP44 is phosphorylated. 8 / 8
| 5 3
sparser
"Although the precise mechanism(s) by which SAC requires phosphorylation is still unclear, it has been suggested that phosphorylation of Cdc20 and USP44 promotes SAC action xref xref xref xref ."
22692537
sparser
"In addition, we produced a mutant human USP44 (USP44-4A) protein that cannot be phosphorylated at four potential cdk1 or mitotic sites (ser-169, -239, -401 and threo-269)."
22692537
rlimsp
"USP44 activity has also been hypothesized to be regulated by phosphorylation, in particular, mitotic phosphorylation is thought to stimulate its deubiquitinating activity required to sustain SAC10."
22692537
rlimsp
"Thus, dephosphorylation of Wee1, Cdc20 and USP44 began concomitantly during spindle assembly and apparently before significant degradation of cyclin. Like the major biochemical reactions of mitosis exit in living cells, checkpoint extracts reproduced the changes in the phosphorylation status of these proteins during M-phase exit (see below), thus, we asked whether these changes depended on the presence of Fcp1."
22692537
sparser
"Phosphorylation of USP44 during Mitosis."
21480003
rlimsp
"Although the precise mechanism(s) by which SAC requires phosphorylation is still unclear, it has been suggested that phosphorylation of Cdc20 and USP44 promotes SAC action4101112."
22692537
sparser
"As with Usp8 phosphorylation of S680, serine phosphorylation of USP16 and USP44 plays a role during mitosis [35,63,64] ."
23333852
sparser
"The stabilization of the APC inhibitory Mad2-Cdc20 complex both in vitro and in vivo pointed to mitotic cyclin-dependent kinases (CDKs) or spindle checkpoint kinases being likely involved in USP44 phosphorylation [ xref ]."
32512887
USP44 is phosphorylated on S351. 2 / 2
2 |
hprd
No evidence text available
19651622
hprd
No evidence text available
19651622
USP44 is phosphorylated on S361. 2 / 2
2 |
hprd
No evidence text available
19651622
hprd
No evidence text available
19651622
USP44 is dephosphorylated.
| 6
USP44 is dephosphorylated. 6 / 6
| 6
sparser
"As previously described for Cdc20 dephosphorylation and Mad2 dissociation from the APC/C–Cdc20 complex xref , we found that Wee1 and USP44 dephosphorylation was prevented when cells were released from nocodazole arrest into a proteasome inhibitor-containing medium ( xref )."
22692537
sparser
"Thus, dephosphorylation of Wee1, Cdc20 and USP44 began concomitantly during spindle assembly and apparently before significant degradation of cyclin."
22692537
sparser
"At mitosis exit, Fcp1 promoted inhibitory Cdk1 phosphorylation by dephosphorylating Wee1, and ubiquitin-dependent cyclin B degradation by dephosphorylating Cdc20 and USP44."
27670139
sparser
"USP44 dephosphorylation was followed in cells transiently transfected with a V5-tagged USP44 expression vector ( xref )."
22692537
sparser
"Once the SAC is satisfied, USP44 dephosphorylation decreases its activity towards CDC20, initiating mitotic exits through APC/C activation [ xref ]."
28900014
sparser
"We also found that a short treatment with a cdk1 inhibitor accelerated Wee1, Cdc20 and USP44 dephosphorylations in control extracts but it failed to do so in Fcp1-depleted extracts ( xref )."
22692537
USP44 is acetylated.
| 2
USP44 is acetylated. 2 / 2
| 2
sparser
"Our data indicate that the USP44-N-CoR complex likely represses transcription by removing H2Bub1 via USP44 and histone acetylation via HDAC3 at the promoter."
27880911
sparser
"Our data indicate that USP44-N-CoR complex likely represses transcription by removing H2Bub1 via USP44 and histone acetylation via HDAC3 at the promoter."
27880911
USP44 affects FOXP3
| 27 6
USP44 binds FOXP3.
| 7 6
USP44 binds FOXP3. 6 / 6
| 6
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"In this study, we confirmed that USP44 indeed associates with FOXP3."
32644293
reach
"Here, the physical association between USP44 and FOXP3 was confirmed by reciprocal co-immunoprecipitation."
32644293
reach
"Recently, a study from our group showed that USP44 also interacts with Foxp3 and prevents its degradation by deubiquitinating K48-type polyubiquitin chains on Foxp3 (185]."
33912156
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"Taken together, these data suggest that USP44 interacts with FOXP3 in Tregs."
32644293
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"USP44 interacts with FOXP3."
32644293
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"An insertion mutation of ZF-UBP also rendered USP44 incapable of pulling down FOXP3 (Fig XREF_FIG F) supporting the conclusion that the USP44 associates with FOXP3 through ZF-proline-rich domain interactions."
32644293
USP44 binds FOXP3. 6 / 6
| 6
sparser
"Taken together, these data suggest that USP44 interacts with FOXP3 in Tregs."
32644293
sparser
"Endogenous co‐IP experiments further supported the notion that FOXP3 and USP44 interact."
32644293
sparser
"An insertion mutation of ZF‐UBP also rendered USP44 incapable of pulling down FOXP3 (Fig  xref F) supporting the conclusion that the USP44 associates with FOXP3 through ZF‐proline‐rich domain interactions."
32644293
sparser
"USP44 interacts with FOXP3."
32644293
sparser
"Recently, a study from our group showed that USP44 also interacts with Foxp3 and prevents its degradation by deubiquitinating K48-type polyubiquitin chains on Foxp3 (185]."
33912156
sparser
"In this study, we confirmed that USP44 indeed associates with FOXP3."
32644293
USP44 binds FOXP3 and K48. 1 / 1
| 1
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"USP44 interacts with and stabilizes FOXP3 by removing K48 linked ubiquitin modifications."
32644293
USP44 deubiquitinates FOXP3.
| 6
USP44 deubiquitinates FOXP3. 4 / 4
| 4
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"USP44 co-operates with USP7 to deubiquitinate FOXP3 and stabilize expression."
32644293
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"Interestingly, USP44 co-operated with USP7 to deubiquitinate and stabilize FOXP3."
32644293
reach
"To this end, we characterized the deubiquitination of FOXP3 by USP44 invitro in the presence of wild-type ubiquitin molecules and mutants lacking all but specific lysine residues."
32644293
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"We therefore investigated whether or not USP44 co-operates with USP7 to deubiquitinate and preserve FOXP3."
32644293
Modified USP44 leads to the deubiquitination of FOXP3. 2 / 2
| 2
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"As expected, USP44 or USP7 expression alone reduced ubiquitination of FOXP3, while co-over-expression of both USP44 and USP7 almost completely eliminated FOXP3 polyubiquitination, suggesting a synergistic role of these two DUBs (Fig XREF_FIG C)."
32644293
reach
"In these experiments, ubiquitination of FOXP3 was decreased by the co-expression of USP44 in the presence of wild-type ubiquitin."
32644293
USP44 increases the amount of FOXP3.
| 5
USP44 increases the amount of FOXP3. 4 / 4
| 4
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"Our current findings suggest that USP44, another DUB without an appreciated immunoregulatory role, can act as a distinct force to support FOXP3 expression and both Treg phenotype and function."
32644293
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"USP44 knockdown in Tregs decreased FOXP3 expression and disrupted patterns of Treg gene expression (i.e., suppression of IL-2 expression)."
32644293
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"Our present findings suggest that targeting factors such as USP44 and USP7 that promote FOXP3 expression at the protein level is a strategy that offers exciting possibilities for the fine tuning of immune responses in cancer."
32644293
reach
"The ability of USP44 to promote FOXP3 expression was evident in our assessment of iTreg induction under limiting TGF-beta levels."
32644293
Modified USP44 increases the amount of FOXP3. 1 / 1
| 1
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"Furthermore, increasing USP44 levels appeared to augment FOXP3 protein levels (Fig XREF_FIG B)."
32644293
USP44 activates FOXP3.
| 4
USP44 activates FOXP3. 4 / 4
| 4
reach
"These results suggest that Tregs devoid of USP44 mediated FOXP3 stabilization are ineffective suppressors of anti-tumor immune responses."
32644293
reach
"Suspecting that USP44 targets FOXP3 for deubiquitination, we again utilized a co-IP approach to test this notion."
32644293
reach
"Combined USP7 and USP44 knockdown, however, even further enhanced FOXP3 degradation (Fig XREF_FIG D, left panel)."
32644293
reach
"USP44 promotes FOXP3 stabilization through deubiquitination."
32644293
USP44 inhibits FOXP3.
| 3
USP44 inhibits FOXP3. 2 / 2
| 2
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"The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation."
32644293
reach
"In contrast, shRNA mediated knockdown of USP44 enhanced the disappearance of FOXP3 protein in Jurkat T cells (XREF_SUPPLEMENTARY)."
32644293
Mutated USP44 inhibits FOXP3. 1 / 1
| 1
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"Furthermore, expression of a catalytically inactive mutant USP44 (" CS ") failed to prevent the modification of FOXP3 in this manner (Figs XREF_FIG A and XREF_FIG)."
32644293
USP44 ubiquitinates FOXP3.
| 2
Modified USP44 leads to the ubiquitination of FOXP3. 1 / 1
| 1
reach
"As expected, USP44 or USP7 expression alone reduced ubiquitination of FOXP3, while co-over-expression of both USP44 and USP7 almost completely eliminated FOXP3 polyubiquitination, suggesting a synergistic role of these two DUBs (Fig XREF_FIG C)."
32644293
USP44 ubiquitinates FOXP3. 1 / 1
| 1
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"USP44 targets K48 linked polyubiquitinated FOXP3."
32644293
USP44 inhibits cell population proliferation. 10 / 17
| 15 2
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"USP44 overexpression elevated the proliferation of CCRF-CEM cells, while USP44 knockdown suppressed the proliferation of Jurkat and MOLT-4 cells."
36483601
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"These results confirmed that USP44 knockdown enhanced the proliferation and migration of Caki-1 cells."
32164618
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"USP44 overexpression inhibits proliferation of 786-O cells and Caki-1 cells."
32164618
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"Taken together, this study demonstrates that USP44 inhibits proliferation while enhances apoptosis in CRC cells by inactivating Wnt and beta-catenin pathway via Axin1 deubiquitination."
32285989
sparser
"Collectively, these data indicated that USP44 inhibited proliferation while promoted apoptosis in CRC by inhibiting Wnt/β-catenin pathway."
32285989
reach
"Depletion of USP44 inhibits proliferation, migration, and invasion in glioma cell lines."
28938551
reach
"USP44 overexpression inhibited the proliferation and migration of 786-O cells and Caki-1 cells significantly."
32164618
reach
"USP44 knockdown enhanced the proliferation and migration of 786-O cells and Caki-1 cells."
32164618
reach
"Collectively, these data indicated that USP44 inhibited proliferation while promoted apoptosis in CRC by inhibiting Wnt and beta-catenin pathway."
32285989
reach
"Taken together, these results demonstrated that USP44 inhibited proliferation of 786-O cells and Caki-1 cells."
32164618
reach
"USP44 overexpression elevated the proliferation of CCRF-CEM cells, while USP44 knockdown suppressed the proliferation of Jurkat and MOLT-4 cells."
36483601
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"Overall, the difference derived from our experimental results indicated that the knockdown of USP44 inhibited proliferation, migration, and invasion in glioma cells."
28938551
reach
"Indeed, knockdown of cyclin D1 or re-expression of USP44 reversed the proliferation of T80 and KLF8 cells back to the levels of the Mock cells (XREF_FIG)."
23222713
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"These results suggested that knockdown of USP44 might inhibit glioma cell proliferation by arresting cell cycle in G2/M phase."
28938551
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"In established glioma cell lines, knockdown of USP44 inhibited the proliferation, migration, and invasion of the cells."
28938551
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"XREF_BIBR The downregulation of miR-143-3p by circFoxo3 increased the level of USP44, which in turn promoted tumor cell proliferation."
33614239
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"These results indicated that knockdown of USP44 inhibited the proliferation of glioma cells."
28938551
reach
"USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer."
32956592
USP44 affects CDC20
1 | 17
USP44 deubiquitinates CDC20.
1 | 13
USP44 deubiquitinates CDC20. 10 / 14
1 | 13
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"Moreover, Usp44, a ubiquitin isopeptidase, has been proposed to prevent the autoubiquitination of Cdc20 and maintain the Mad2-Cdc20 interaction during checkpoint activation."
21439394
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"USP44 knockdown increased Cdc20 polyubiquitination and centrosomal Cdc20-APC activity in neurons, and correspondingly promoted the elaboration of dendrites."
20195072
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"Knockdown of USP44 in neurons dramatically increased the polyubiquitination of Cdc20 and centrosomal Cdc20-APC activity, confirming that endogenous USP44 deubiquitinates Cdc20 in neurons (XREF_FIG)."
19167333
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"We have previously shown that USP44 deubiquitinates CDC20 to negatively regulate the anaphase promoting complex during the spindle checkpoint."
19615732
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"USP44 deubiquitinates the APC coactivator Cdc20 both in vitro and in vivo, and thereby directly counteracts the APC driven disassembly of Mad2-Cdc20 complexes (discussed in an accompanying paper)."
17443180
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"Conversely, the deubiquitinating enzyme USP44 deubiquitinates Cdc20 and drives the assembly of the inhibitory SAC complexes."
18645024
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"USP44 deubiquitinates Cdc20 and enables the stabilization of the inactive complex MAD2, CDC20, and APC/C [XREF_BIBR]."
23246971
reach
"Knocking down USP14 arrests cell cycle at the G2/M phase and inhibits the proliferation and migration of breast cancer cells, USP44 deubiquitinates the APC-inhibitory Mad2 and Cdc20 complex, thereby preventing anaphase onset."
33643919
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"This study indicates that USP44 reduces Cdc20 autoubiquitination and protects the Mad2-Cdc20-containing checkpoint complexes from disassembly, although it remains to be determined whether USP44 also directly deubiquitinates mitotic APC/C substrates and prevents their degradation."
17650307
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"For example, USP44 directly deubiquitinates CDC20 and counteracts the APC driven disassembly of the Mad2 and CDC20 complex, which regulates the proper mitotic timing and the spindle checkpoint function 3."
29449677
USP44 activates CDC20.
| 1
USP44 activates CDC20. 1 / 4
| 1
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"Moreover, Usp44 inhibits Cdc20 degradation and counteracts UbcH10 to decelerate the metaphase to anaphase transition [XREF_BIBR]."
19302711
USP44 ubiquitinates CDC20.
| 3
USP44 leads to the ubiquitination of CDC20. 3 / 3
| 3
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"The results show that USP44 can be directly combined with centrosomal central protein 2 (CETN2) to regulate the spindle geometry, intermediate distance and centrosome separation, while the ubiquitination of CDC20 mediated by USP44 can maintain the integrity of metaphase plate, prevent cell division defects and chromosomal aneuploidy."
32266120
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"Knockdown of USP44 in neurons dramatically increased the polyubiquitination of Cdc20 and centrosomal Cdc20-APC activity, confirming that endogenous USP44 deubiquitinates Cdc20 in neurons (XREF_FIG)."
19167333
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"Knockdown of the Cdc20 deubiquitinase USP44 in neurons increases Cdc20 polyubiquitination and correspondingly augments dendrite growth and arborization, suggesting that the dynamic regulation of Cdc20 polyubiquitination is critical for controlling dendrite morphogenesis (XREF_FIG)."
21439392
USP44 affects H2Bub1
| 14
USP44 increases the amount of H2Bub1.
| 3
USP44 increases the amount of H2Bub1. 2 / 2
| 2
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"Several studies have indicated that the decrease in H2Bub1 levels induced by USP44 results in autophagy activation 24."
32934196
reach
"Depletion of either USP44 or TBL1XR1 impairs the invasiveness of MDA-MB-231 cells in vitro and causes an increase of global H2Bub1 levels."
27880911
Modified USP44 increases the amount of H2Bub1. 1 / 1
| 1
reach
"Indeed, depletion of USP44 expression by RNAi increased the levels of H2Bub1 and decreased the activity of autophagy significantly, as the levels of LC3B II were decreased and the p62 levels were increased after USP44 RNAi."
28180298
USP44 deubiquitinates H2Bub1.
| 3
USP44 deubiquitinates H2Bub1. 3 / 3
| 3
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"USP44 deubiquitinates H2Bub1 as part of N-CoR."
27880911
reach
"To further define USP44 functions, we tested the ability of recombinant USP44 to deubiquitinate H2Bub1 in vitro (XREF_SUPPLEMENTARY, compare lane 1 to lane 2 and 3)."
27880911
reach
"USP44 promotes H2Bub1 deubiquitylation."
22681888
USP44 binds H2Bub1.
| 3
USP44 binds H2Bub1. 3 / 3
| 3
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"Interestingly, overexpression of linc-RA1 decreased the interaction between H2Bub1 and USP44 in M059J cells after IR, while knockdown of linc-RA1 increased the interaction between H2Bub1 and USP44 in M059K cells after IR."
32934196
reach
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
reach
"These results indicated that linc-RA1 could stabilize the level of H2Bub1 by inhibiting the interaction between H2Bub1 and USP44."
32934196
USP44 inhibits H2Bub1.
| 2
USP44 inhibits H2Bub1. 2 / 2
| 2
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"Consistently, H2Bub1 inhibition by USP44 overexpression also produced similar effects."
32934196
reach
"Moreover, H2Bub1 inhibition by USP44 overexpression could partly restore the decreased gamma-H2AX foci number caused by linc-RA1 overexpression in M059J cells."
32934196
USP44 activates H2Bub1.
| 2
USP44 activates H2Bub1. 2 / 2
| 2
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"As expected, depletion of USP44 led to increase of H2Bub1 at this promoter, but had no effect on the H3K9/14ac."
27880911
reach
"It will be of interest to find out whether, in addition to deregulating the spindle checkpoint, USP44 contributes to the pathology of this and perhaps other malignancies by quenching H2Bub1 and enforcing a less differentiated phenotype."
22681888
USP44 decreases the amount of H2Bub1.
| 1
Modified USP44 decreases the amount of H2Bub1. 1 / 1
| 1
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"Furthermore, overexpression of USP44 in HeLa cells, possessing low endogenous USP44, significantly reduced H2Bub1 levels : in contrast, catalytically inactive USP44 failed to exert such an effect (XREF_FIG)."
22681888
FOXP3 affects USP44
| 7 6
USP44 binds FOXP3. 6 / 6
| 6
reach
"In this study, we confirmed that USP44 indeed associates with FOXP3."
32644293
reach
"Here, the physical association between USP44 and FOXP3 was confirmed by reciprocal co-immunoprecipitation."
32644293
reach
"Recently, a study from our group showed that USP44 also interacts with Foxp3 and prevents its degradation by deubiquitinating K48-type polyubiquitin chains on Foxp3 (185]."
33912156
reach
"Taken together, these data suggest that USP44 interacts with FOXP3 in Tregs."
32644293
reach
"USP44 interacts with FOXP3."
32644293
reach
"An insertion mutation of ZF-UBP also rendered USP44 incapable of pulling down FOXP3 (Fig XREF_FIG F) supporting the conclusion that the USP44 associates with FOXP3 through ZF-proline-rich domain interactions."
32644293
USP44 binds FOXP3. 6 / 6
| 6
sparser
"Taken together, these data suggest that USP44 interacts with FOXP3 in Tregs."
32644293
sparser
"Endogenous co‐IP experiments further supported the notion that FOXP3 and USP44 interact."
32644293
sparser
"An insertion mutation of ZF‐UBP also rendered USP44 incapable of pulling down FOXP3 (Fig  xref F) supporting the conclusion that the USP44 associates with FOXP3 through ZF‐proline‐rich domain interactions."
32644293
sparser
"USP44 interacts with FOXP3."
32644293
sparser
"Recently, a study from our group showed that USP44 also interacts with Foxp3 and prevents its degradation by deubiquitinating K48-type polyubiquitin chains on Foxp3 (185]."
33912156
sparser
"In this study, we confirmed that USP44 indeed associates with FOXP3."
32644293
USP44 binds FOXP3 and K48. 1 / 1
| 1
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"USP44 interacts with and stabilizes FOXP3 by removing K48 linked ubiquitin modifications."
32644293
USP44 affects NCOR1
2 | 1 7
USP44 binds NCOR1.
2 | 7
USP44 binds NCOR1. 6 / 6
2 | 4
sparser
"Further cell fractionation experiments confirmed associations of USP44 and N-CoR complex components with chromatin ( Figure S1 D)."
27880911
sparser
"Further cell fractionation experiments confirmed associations of USP44 and N-CoR complex components with chromatin ( xref )."
27880911
sparser
"Overall, our study demonstrates that USP44 associates with the N-CoR complex to regulate H2Bub1 levels at N-CoR target genes and that compromising the function of USP44 or the N-CoR complex impairs th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
sparser
"Overall, our study demonstrates that USP44 associates with the N-CoR complex to regulate H2Bub1 levels at N-CoR target genes and that compromising the function of USP44 or N-CoR complex impairs the invasiveness of breast cancer cells."
27880911
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
USP44 binds FH and NCOR1. 2 / 2
| 2
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( xref )."
27880911
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( Figure 1 C)."
27880911
CETN2 binds USP44 and NCOR1. 1 / 1
| 1
sparser
"Collectively, these results demonstrate that USP44 associates with the N-CoR complex independently of CETN2 in the nucleus, indicating that this DUB likely functions in multiple processes."
27880911
USP44 inhibits NCOR1.
| 1
USP44 inhibits NCOR1. 1 / 1
| 1
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"USP44 enhances the repressive activity of N-CoR."
27880911
USP44 affects Histone_H2B
| 9 1
USP44 deubiquitinates Histone_H2B.
| 8
USP44 deubiquitinates Histone_H2B. 8 / 8
| 8
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"Our results indicate that both the deubiquitination of histone H2B by USP44 and deacetylation of histone H3 by HDAC3 contribute to N-CoR mediated transcriptional repression (XREF_FIG)."
27880911
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"29 , 30 Of note, USP44 deubiquitinates histone H2B both in vivo and in vitro, which contributes to N‐CoR (USP44 is a part of the N‐CoR complex)‐mediated repression of target genes."
32394588
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"However, whether USP44 directly deubiquitinates histone H2B or how its activity is targeted to chromatin is not known."
27880911
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"As part of N-CoR, USP44 deubiquitinates H2B both in vivo and in vitro, and it contributes to N-CoR-mediated repression of target genes, including a genome integrated luciferase reporter (Vaquero et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
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"USP44 within N-CoR deubiquitinates H2B in vitro and in vivo, and ablation of USP44 impairs the repressive activity of the N and CoR complex."
27880911
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"However, whether USP44 directly deubiquitinates histone H2B or how its activity is targeted to chromatin are not known."
27880911
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"USP44 negatively regulates H2B ubiquitination during embryonic stem cell development [XREF_BIBR]."
23845989
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"Our results indicate that both the deubiquitination of histone H2B by USP44 and deacetylation of histone H3 by HDAC3 contribute to N-CoR-mediated transcriptional repression."
27880911
USP44 ubiquitinates Histone_H2B.
| 1
USP44 ubiquitinates Histone_H2B. 1 / 1
| 1
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"The results showed that the levels of RNF20, RNF40, and USP44 were unchanged with linc-RA1 upregulation or downregulation, indicating that linc-RA1 regulates the monoubiquitination of histone H2B, independent of the expression level of ubiquitin ligases RNF20/40 or deubiquitinating enzyme USP44."
32934196
USP44 binds Histone_H2B.
| 1
Histone_H2B binds USP44 and cor. 1 / 1
| 1
sparser
"USP44 was also found to be a negative regulator of H2B ubiquitylation (Fuchs et al , xref ; Lan et al , xref ) by mainly associating with chromatin and forming a complex with N‐COR subunits in the nucleus."
32644293
USP44 affects CETN2
5 | 3 2
CETN2 binds USP44. 9 / 9
5 | 3 1
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"USP44 interacts with CETN2 (Centrin2) and, although the targets of USP44 at the centrosome remain to be elucidated, catalytically inactive or CETN2 binding mutants of USP44 fail to rescue centrosome positioning defects."
28900014
reach
"The USP44 and CETN2 complex is known to play an important role in preventing chromosome segregation errors during mitosis."
27880911
biogrid
No evidence text available
19615732
sparser
"USP44 interacts with CETN2 (Centrin2) and, although the targets of USP44 at the centrosome remain to be elucidated, catalytically inactive or CETN2-binding mutants of USP44 fail to rescue centrosome positioning defects."
28900014
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
reach
"The USP44 and CETN2 complex is known to play an important role in preventing chromosome segregation errors during mitosis (Zhang et al., 2012)."
27880911
biogrid
No evidence text available
27880911
biogrid
No evidence text available
28514442
CETN2 binds USP44 and NCOR1. 1 / 1
| 1
sparser
"Collectively, these results demonstrate that USP44 associates with the N-CoR complex independently of CETN2 in the nucleus, indicating that this DUB likely functions in multiple processes."
27880911
USP44 affects DDB2
| 9
USP44 deubiquitinates DDB2.
| 6
USP44 deubiquitinates DDB2. 6 / 6
| 6
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"Ubiquitination of DDB2 was reversed by the inclusion of wild-type USP44 but not the catalytically inactive USP44C281A."
33937266
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"USP44 Deubiquitinates and Prevents the Premature Degradation of DDB2."
33937266
reach
"Here we show that the tumor suppressor USP44 directly deubiquitinates DDB2 to prevent its premature degradation and is selectively required for CPD repair."
33937266
reach
"One possibility is that USP44 de-ubiquitinates DDB2 once it has been released, allowing it to be recycled back onto persisting CPDs."
33937266
reach
"Consistent with the selective CPD repair defect in Usp44 null cells, we find that USP44 deubiquitinates the recognition protein DDB2 to facilitate its accumulation on DNA lesions and facilitate the subsequent recruitment of XPC."
33937266
reach
"These data lead us to conclude that USP44 deubiquitinates DDB2 following UV exposure and prevents its premature degradation."
33937266
USP44 activates DDB2.
| 2
USP44 activates DDB2. 2 / 2
| 2
reach
"USP44 Promotes the Accumulation of DDB2 on Damaged DNA."
33937266
reach
"Data supporting this model is the finding that USP44 stimulates DDB2 accumulation directly upon DNA damage induction (XREF_FIG)."
33937266
USP44 binds DDB2.
| 1
USP44 binds DDB2. 1 / 1
| 1
reach
"The severe reduction of DDB2 accumulation kinetics at damage sites in living cells is most consistent with a direct effect of USP44 on chromatin bound DDB2 rather than enhanced recycling."
33937266
USP44 activates Chromosomal Instability.
| 1 6
USP44 activates Chromosomal Instability. 7 / 8
| 1 6
reach
"Aberrant expression of USP44 leads CIN in cells; however, the correlation between USP44 and DNA aneuploidy in gastric cancer is largely unknown."
28544703
reach
"Overexpression of USP44 leads to CIN."
28544703
reach
"These results indicate that stable overexpression of USP44 leads to CIN in a human cell line."
28544703
reach
"We conclude that USP44 levels are increased in T-ALL and that USP44 induced CIN may contribute to the pathogenesis of this disease."
21853124
reach
"Finally, we investigated whether high USP44 expression caused CIN."
28544703
reach
"A previous study reported that overexpression of USP44 in mouse embryonic fibroblasts induced CIN 13."
28544703
eidos
"USP44 , which belongs to USP family , can induce chromosome instability , resulting in DNA aneuploidy in GC ( Zhang et al ., 2011 ; Nishimura et al ., 2017 ) ."
34150756
USP44 inhibits Chromosomal Instability. 1 / 1
| 1
reach
"USP44 is an important regulator in mitosis, and therefore suppression or overexpression of USP44 leads to aneuploidy, resulting in an induction of CIN."
28544703
NCOR1 affects USP44
2 | 7
USP44 binds NCOR1. 6 / 6
2 | 4
sparser
"Further cell fractionation experiments confirmed associations of USP44 and N-CoR complex components with chromatin ( Figure S1 D)."
27880911
sparser
"Further cell fractionation experiments confirmed associations of USP44 and N-CoR complex components with chromatin ( xref )."
27880911
sparser
"Overall, our study demonstrates that USP44 associates with the N-CoR complex to regulate H2Bub1 levels at N-CoR target genes and that compromising the function of USP44 or the N-CoR complex impairs th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
sparser
"Overall, our study demonstrates that USP44 associates with the N-CoR complex to regulate H2Bub1 levels at N-CoR target genes and that compromising the function of USP44 or N-CoR complex impairs the invasiveness of breast cancer cells."
27880911
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
USP44 binds FH and NCOR1. 2 / 2
| 2
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( xref )."
27880911
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( Figure 1 C)."
27880911
CETN2 binds USP44 and NCOR1. 1 / 1
| 1
sparser
"Collectively, these results demonstrate that USP44 associates with the N-CoR complex independently of CETN2 in the nucleus, indicating that this DUB likely functions in multiple processes."
27880911
reach
"Depletion of USP44 inhibits proliferation, migration, and invasion in glioma cell lines."
28938551
reach
"Similarly, the deletion of USP44, an integral component of NCoR, impaired the ability of NCoR to regulate gene expression and suppressed breast cancer cell invasiveness [29]."
31565033
reach
"Depletion of USP44 significantly impaired the invasiveness of MDA-MB-231 cells in vitro and led to an increase of global H2Bub1 levels (XREF_FIG and XREF_SUPPLEMENTARY)."
27880911
reach
"The depletion of USP44 significantly impaired the invasiveness of MDA-MB-231 cells in vitro, and it led to an increase in global H2Bub1 levels."
27880911
reach
"Knockdown of USP44 inhibited proliferation, migration and invasion, induced apoptosis, and arrested cell cycle in G2/M phase in the established glioma cell lines."
28938551
USP44 activates Neoplasm Invasiveness.
| 3
reach
"Overall, the difference derived from our experimental results indicated that the knockdown of USP44 inhibited proliferation, migration, and invasion in glioma cells."
28938551
reach
"In established glioma cell lines, knockdown of USP44 inhibited the proliferation, migration, and invasion of the cells."
28938551
reach
"Consistently, the in vivo study revealed that USP44 knockdown restricted the leukemic engraftments in the bone marrow and spleens and reduced the infiltration of T-ALL cells in the livers and lungs."
36483601
USP44 affects TBL1X
3 | 2 2
TBL1X binds USP44. 5 / 5
3 | 2
reach
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together."
27880911
biogrid
No evidence text available
27880911
reach
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together (XREF_FIG)."
27880911
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
TBL1X binds USP44 and TBL1XR1. 2 / 2
| 2
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( xref )."
27880911
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( Figure 2 A)."
27880911
USP44 affects STING1
| 1 6
USP44 binds STING1.
| 6
USP44 binds STING1. 6 / 6
| 6
sparser
"Importantly, co-immunoprecipitation experiments with the membraneous fraction demonstrated that USP44 associated with MITA on membranes ( xref , bottom panel)."
31968013
sparser
"Consistently, transient transfection and coimmunoprecipitation experiments showed that USP44 interacted with MITA but not cGAS, TBK1, IKKε or IRF3 ( xref )."
31968013
sparser
"USP44 interacted with MITA following HSV-1 infection."
31968013
sparser
"Using this cell line, we found that USP44 was associated with MITA after HSV-1 infection ( xref )."
31968013
sparser
"Given that MITA is a transmembrane protein and that the MITA-USP44 interaction was detected in the membraneous fraction after HSV-1 infection, a simple explanation is that USP44 interacts with MITA and is recruited to membranes following viral infection."
31968013
sparser
"Here we found that the deubiquitinating enzymes USP44 associates with MITA and removes the K48-linked polyubiquitin chains from MITA, therefore maintains the stability of MITA after DNA virus infection."
31968013
USP44 inhibits STING1.
| 1
USP44 inhibits STING1. 1 / 1
| 1
eidos
"Taken together , these findings indicate that USP44 prevents MITA from undergoing proteasome-mediated degradation by removing K48-linked polyubiquitination chains at K236 of MITA after DNA virus infection ."
31968013
USP44 affects CTN
| 7
USP44 binds CTN. 7 / 7
| 7
reach
"In addition, USP44 localizes to the centrosome and interacts with the centriole protein Centrin."
29449677
reach
"Similarly, and demonstrating a requirement for the USP44 and Centrin complex, the centrin binding mutant USP44W162A failed to rescue CPD repair."
33937266
reach
"The mechanism by which USP44 would regulate genome stability is not fully understood yet, but both USP44 DUB activity and its ability to bind centrin appear to be indispensable for this function [XREF_BIBR]."
25003721
reach
"Because of the direct interaction between USP44 and centrin, and the known function of centrin as a cofactor in NER, we asked whether USP44 loss affects the response to UV induced DNA damage."
33937266
reach
"The binding of USP44 with centrin, together with the predominant nuclear localization of USP44, led us to question the potential role of USP44 in NER."
33937266
reach
"In line with this, our data demonstrate the requirement for centrin binding by USP44, suggesting that DDB2 is de-ubiquitinated while bound at the UV induced lesion by XPC-centrin recruited USP44."
33937266
reach
"The USP44 and Centrin complex is required for proper centrosome separation, and the loss of this function results in aneuploidy 4."
29449677
USP44 affects AXIN1
| 3 4
USP44 binds AXIN1.
| 1 4
USP44 binds AXIN1. 5 / 5
| 1 4
sparser
"Further study uncovered that USP44 interacted with Axin1 and reduced the ubiquitination of Axin1."
32285989
reach
"Further study uncovered that USP44 interacted with Axin1 and reduced the ubiquitination of Axin1."
32285989
sparser
"Further study uncovered that USP44 interacted with Axin1 and reduced the ubiquitination of Axin1."
| PMC
sparser
"We used the anti‐USP44 or anti‐Axin1 antibody to pull down the protein complex in HT29 and HCT116 cell lines, and found that USP44 interacted with Axin1 (Figure  xref )."
| PMC
sparser
"Our further experiments found that USP44 interacted with Axin1 and reduced the ubiquitination of Axin1, strongly supporting our speculation."
| PMC
USP44 deubiquitinates AXIN1.
| 1
USP44 deubiquitinates AXIN1. 1 / 1
| 1
reach
"This indicates that USP44 deubiquitination of Axin1 increases beta-catenin degradation, inhibits Wnt and beta-catenin signaling, and affects CRC [XREF_BIBR]."
32486158
USP44 activates AXIN1.
| 1
USP44 activates AXIN1. 1 / 1
| 1
reach
"We found that USP44 overexpression increased Axin1 protein while decreased beta-catenin, c-myc and Cyclin D1 proteins, suggesting that USP44 inhibited the activation of Wnt and beta-catenin pathway."
32285989
TGFB affects USP44
| 1 6
TGFB activates USP44.
| 1 3
TGFB activates USP44. 4 / 4
| 1 3
reach
"Suspecting that USP44 may be up-regulated in T cells by TGF-beta, we examined the promoter of the mouse and human USP44 gene using R-vista analysis software."
32644293
reach
"During iTreg differentiation, TGF-beta signaling induces USP44 upregulation."
33912156
eidos
"Notably , TGF-beta induces USP44 expression during iTreg differentiation ."
32644293
reach
"Interestingly, ablating TGF-beta signaling in this system with an antibody neutralizing the cytokine reduced USP44 expression in cells stimulated with PMA and Iono without exogenous TGF-beta (Fig XREF_FIG C), suggesting that induced USP44 activity may be augmented by trace amounts of TGF-beta in the serum complemented culture media (RPMI) used in these experiments."
32644293
TGFB increases the amount of USP44.
| 3
TGFB increases the amount of USP44. 3 / 3
| 3
reach
"Notably, TGF-beta induces USP44 expression during iTreg differentiation."
32644293
reach
"USP44 expression is up-regulated by TGF-beta during Treg differentiation."
32644293
reach
"These findings strongly suggest that USP44 expression in Tregs is largely driven by TGF-beta and SMAD signaling."
32644293
TBL1X affects USP44
3 | 2 2
TBL1X binds USP44. 5 / 5
3 | 2
reach
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together."
27880911
biogrid
No evidence text available
27880911
reach
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together (XREF_FIG)."
27880911
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
TBL1X binds USP44 and TBL1XR1. 2 / 2
| 2
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( xref )."
27880911
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( Figure 2 A)."
27880911
CTN affects USP44
| 7
USP44 binds CTN. 7 / 7
| 7
reach
"In addition, USP44 localizes to the centrosome and interacts with the centriole protein Centrin."
29449677
reach
"Similarly, and demonstrating a requirement for the USP44 and Centrin complex, the centrin binding mutant USP44W162A failed to rescue CPD repair."
33937266
reach
"The mechanism by which USP44 would regulate genome stability is not fully understood yet, but both USP44 DUB activity and its ability to bind centrin appear to be indispensable for this function [XREF_BIBR]."
25003721
reach
"Because of the direct interaction between USP44 and centrin, and the known function of centrin as a cofactor in NER, we asked whether USP44 loss affects the response to UV induced DNA damage."
33937266
reach
"The binding of USP44 with centrin, together with the predominant nuclear localization of USP44, led us to question the potential role of USP44 in NER."
33937266
reach
"In line with this, our data demonstrate the requirement for centrin binding by USP44, suggesting that DDB2 is de-ubiquitinated while bound at the UV induced lesion by XPC-centrin recruited USP44."
33937266
reach
"The USP44 and Centrin complex is required for proper centrosome separation, and the loss of this function results in aneuploidy 4."
29449677
USP44 affects apoptotic process
| 6
USP44 inhibits apoptotic process.
| 4
reach
"USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating Wnt and beta-catenin pathway via Axin1 deubiquitination."
32285989
reach
"Knockdown of USP44 inhibited proliferation, migration and invasion, induced apoptosis, and arrested cell cycle in G2/M phase in the established glioma cell lines."
28938551
reach
"Interestingly, WDR5 overexpression abolished the apoptosis induced by USP44 knockdown."
36483601
reach
"However, USP44 knockdown induced apoptosis in Jurkat and MOLT-4 cells, with an upheaval among cleaved caspase-3 and PARP levels."
36483601
USP44 activates apoptotic process.
| 2
reach
"Down-regulation of USP44 promotes the apoptosis of glioma cells in vitro."
28938551
reach
"Meanwhile, downregulating USP44 also induced apoptosis."
28938551
USP44 affects TBL1XR1
2 | 2 2
USP44 binds TBL1XR1. 4 / 4
2 | 2
reach
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together (XREF_FIG)."
27880911
reach
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together."
27880911
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
TBL1X binds USP44 and TBL1XR1. 2 / 2
| 2
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( xref )."
27880911
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( Figure 2 A)."
27880911
USP44 affects PTTG1
| 4 2
USP44 binds PTTG1.
| 3 2
USP44 binds PTTG1. 5 / 5
| 3 2
sparser
"Down-regulation of oncoprotein securin was detected in USP44 deficient cells, and the interaction of endogenous USP44 and securin was confirmed by immunoprecipitation in U251MG cells, which indicated that securin was a substrate of USP44, and might be stabilized by USP44."
28938551
reach
"Down-regulation of oncoprotein securin was detected in USP44 deficient cells, and the interaction of endogenous USP44 and securin was confirmed by immunoprecipitation in U251MG cells, which indicated that securin was a substrate of USP44, and might be stabilized by USP44."
28938551
sparser
"Existing evidence verified that Cyclin B1 was a substrate of USP44, but the interaction between securin and USP44 was still unknown [ xref ]."
28938551
reach
"Existing evidence verified that Cyclin B1 was a substrate of USP44, but the interaction between securin and USP44 was still unknown [XREF_BIBR]."
28938551
reach
"The result of immunoprecipitation assay confirmed the specific interaction of endogenous USP44 and securin for the first time."
28938551
USP44 activates PTTG1.
| 1
USP44 activates PTTG1. 1 / 1
| 1
reach
"Securin is the catalytic substrate of USP44, knockdown of USP44 promotes degradation of securin."
28938551
TBL1XR1 affects USP44
2 | 2 2
USP44 binds TBL1XR1. 4 / 4
2 | 2
reach
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together (XREF_FIG)."
27880911
reach
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together."
27880911
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
TBL1X binds USP44 and TBL1XR1. 2 / 2
| 2
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( xref )."
27880911
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( Figure 2 A)."
27880911
STING1 affects USP44
| 6
USP44 binds STING1. 6 / 6
| 6
sparser
"Importantly, co-immunoprecipitation experiments with the membraneous fraction demonstrated that USP44 associated with MITA on membranes ( xref , bottom panel)."
31968013
sparser
"Consistently, transient transfection and coimmunoprecipitation experiments showed that USP44 interacted with MITA but not cGAS, TBK1, IKKε or IRF3 ( xref )."
31968013
sparser
"USP44 interacted with MITA following HSV-1 infection."
31968013
sparser
"Using this cell line, we found that USP44 was associated with MITA after HSV-1 infection ( xref )."
31968013
sparser
"Given that MITA is a transmembrane protein and that the MITA-USP44 interaction was detected in the membraneous fraction after HSV-1 infection, a simple explanation is that USP44 interacts with MITA and is recruited to membranes following viral infection."
31968013
sparser
"Here we found that the deubiquitinating enzymes USP44 associates with MITA and removes the K48-linked polyubiquitin chains from MITA, therefore maintains the stability of MITA after DNA virus infection."
31968013
DNMT3B affects USP44
| 4 2
DNMT3B binds USP44.
| 2
USP44 binds DNMT3A and DNMT3B. 2 / 2
| 2
sparser
"The results showed that both DNMT3a and DNMT3b bound to the promoter region of the USP44 gene and that the binding was significantly decreased after starvation (Figure xref )."
28180298
sparser
"Furthermore, consistent with the results from human cell lines (Figure xref ), the methylation of the USP44 gene promoter in mESCs is also likely regulated by DNMT3a and DNMT3b, as our chromatin immunoprecipitation assay indicated that differentiation promotes the binding of both DNMT3a and DNMT3b to the USP44 gene promoter (Figure xref )."
28180298
DNMT3B inhibits USP44.
| 1
DNMT3B inhibits USP44. 1 / 1
| 1
reach
"Starvation induced USP44 up-regulation is mediated by DNMT3a and DNMT3b."
28180298
DNMT3B increases the amount of USP44.
| 1
Modified DNMT3B increases the amount of USP44. 1 / 1
| 1
reach
"The results showed that the depletion of DNMT3a and DNMT3b expression significantly increased the transcriptional levels of USP44, confirming that DNMT3a and DNMT3b are transcriptional silencers of the USP44 gene."
28180298
DNMT3B decreases the amount of USP44.
| 1
DNMT3B decreases the amount of USP44. 1 / 1
| 1
reach
"This result supports our biochemical analysis showing that DNMT3a and DNMT3b suppress the transcription of USP44 by regulating the DNA methylation of the gene."
28180298
DNMT3B activates USP44.
| 1
DNMT3B activates USP44. 1 / 1
| 1
reach
"Furthermore, the starvation induced H2Bub1 decrease and autophagy activation are shown to be regulated by the deubiquitinase USP44, which is transcriptionally targeted by the de novo DNA methyltransferases DNMT3a and DNMT3b."
28180298
DNMT3A affects USP44
| 4 2
DNMT3A binds USP44.
| 2
USP44 binds DNMT3A and DNMT3B. 2 / 2
| 2
sparser
"The results showed that both DNMT3a and DNMT3b bound to the promoter region of the USP44 gene and that the binding was significantly decreased after starvation (Figure xref )."
28180298
sparser
"Furthermore, consistent with the results from human cell lines (Figure xref ), the methylation of the USP44 gene promoter in mESCs is also likely regulated by DNMT3a and DNMT3b, as our chromatin immunoprecipitation assay indicated that differentiation promotes the binding of both DNMT3a and DNMT3b to the USP44 gene promoter (Figure xref )."
28180298
DNMT3A inhibits USP44.
| 1
DNMT3A inhibits USP44. 1 / 1
| 1
reach
"Starvation induced USP44 up-regulation is mediated by DNMT3a and DNMT3b."
28180298
DNMT3A increases the amount of USP44.
| 1
Modified DNMT3A increases the amount of USP44. 1 / 1
| 1
reach
"The results showed that the depletion of DNMT3a and DNMT3b expression significantly increased the transcriptional levels of USP44, confirming that DNMT3a and DNMT3b are transcriptional silencers of the USP44 gene."
28180298
DNMT3A decreases the amount of USP44.
| 1
DNMT3A decreases the amount of USP44. 1 / 1
| 1
reach
"This result supports our biochemical analysis showing that DNMT3a and DNMT3b suppress the transcription of USP44 by regulating the DNA methylation of the gene."
28180298
DNMT3A activates USP44.
| 1
DNMT3A activates USP44. 1 / 1
| 1
reach
"Furthermore, the starvation induced H2Bub1 decrease and autophagy activation are shown to be regulated by the deubiquitinase USP44, which is transcriptionally targeted by the de novo DNA methyltransferases DNMT3a and DNMT3b."
28180298
Centrin affects USP44
| 5
USP44 binds centrin. 5 / 5
| 5
sparser
"Similarly, and demonstrating a requirement for the USP44-Centrin complex, the centrin binding mutant USP44 W 162A(which is fully catalytically active; xref ) failed to rescue CPD repair."
33937266
sparser
"Based on our observation that USP44 binds the XPC partner centrin, we hypothesized that it played a role in NER."
33937266
sparser
"Because of the direct interaction between USP44 and centrin, and the known function of centrin as a cofactor in NER, we asked whether USP44 loss affects the response to UV induced DNA damage."
33937266
sparser
"The binding of USP44 with centrin, together with the predominant nuclear localization of USP44 ( xref ; xref ), led us to question the potential role of USP44 in NER."
33937266
sparser
"In line with this, our data demonstrate the requirement for centrin binding by USP44, suggesting that DDB2 is de-ubiquitinated while bound at the UV-induced lesion by XPC-centrin recruited USP44."
33937266
PTTG1 affects USP44
| 3 2
USP44 binds PTTG1. 5 / 5
| 3 2
sparser
"Down-regulation of oncoprotein securin was detected in USP44 deficient cells, and the interaction of endogenous USP44 and securin was confirmed by immunoprecipitation in U251MG cells, which indicated that securin was a substrate of USP44, and might be stabilized by USP44."
28938551
reach
"Down-regulation of oncoprotein securin was detected in USP44 deficient cells, and the interaction of endogenous USP44 and securin was confirmed by immunoprecipitation in U251MG cells, which indicated that securin was a substrate of USP44, and might be stabilized by USP44."
28938551
sparser
"Existing evidence verified that Cyclin B1 was a substrate of USP44, but the interaction between securin and USP44 was still unknown [ xref ]."
28938551
reach
"Existing evidence verified that Cyclin B1 was a substrate of USP44, but the interaction between securin and USP44 was still unknown [XREF_BIBR]."
28938551
reach
"The result of immunoprecipitation assay confirmed the specific interaction of endogenous USP44 and securin for the first time."
28938551
AXIN1 affects USP44
| 1 4
USP44 binds AXIN1. 5 / 5
| 1 4
sparser
"Further study uncovered that USP44 interacted with Axin1 and reduced the ubiquitination of Axin1."
32285989
reach
"Further study uncovered that USP44 interacted with Axin1 and reduced the ubiquitination of Axin1."
32285989
sparser
"Further study uncovered that USP44 interacted with Axin1 and reduced the ubiquitination of Axin1."
| PMC
sparser
"We used the anti‐USP44 or anti‐Axin1 antibody to pull down the protein complex in HT29 and HCT116 cell lines, and found that USP44 interacted with Axin1 (Figure  xref )."
| PMC
sparser
"Our further experiments found that USP44 interacted with Axin1 and reduced the ubiquitination of Axin1, strongly supporting our speculation."
| PMC
USP7 affects USP44
| 1 3
USP7 binds USP44. 3 / 3
| 1 2
reach
"The cooperation between USP44 and USP7 was also seen in human iTregs."
32644293
sparser
"Co‐IP experiments revealed that USP44 and USP7 associated with each other in a complex (Fig  xref A)."
32644293
sparser
"It has been reported that USP44 and USP7 bind to the OCT-3/4 promoter, but their roles in stem cell differentiation and cellular reprogramming should be further investigated [ xref ]."
32178477
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
USP44 affects cell cycle
| 1 3
USP44 activates cell cycle.
| 1 2
USP44 activates cell cycle. 3 / 3
| 1 2
reach
"These results suggested that knockdown of USP44 might inhibit glioma cell proliferation by arresting cell cycle in G2/M phase."
28938551
reach
"Our data showed that knockdown of USP44 arrested the cell cycle in G2/M phase concomitantly with the degradation of securin."
28938551
eidos
"In addition , USP44 accelerated the cell cycle progression , with boosted cyclinD and PCNA levels ."
36483601
USP44 inhibits cell cycle.
| 1
USP44 inhibits cell cycle. 1 / 1
| 1
reach
"Knockdown of USP44 inhibited proliferation, migration and invasion, induced apoptosis, and arrested cell cycle in G2/M phase in the established glioma cell lines."
28938551
USP44 affects autophagy
| 4
USP44 inhibits autophagy. 3 / 3
| 3
reach
"Moreover, downregulation of USP44 encoding gene blocks the induction of autophagy in mESCs (mouse embryonic stem cells) (XREF_FIG H)."
30126257
reach
"Mechanistically, linc-RA1 stabilized the level of H2B K120 monoubiquitination (H2Bub1) by combining with H2B and inhibiting the interaction between H2Bub1 and ubiquitin specific protease 44 (USP44), which inhibited autophagy, thus contributing to glioma radioresistance."
32934196
reach
"Knockdown of Usp44 results in the maintenance of H2Bub1 upon starvation and abolishes the change in expression of starvation induced autophagy related genes."
30126257
Modified USP44 inhibits autophagy. 1 / 1
| 1
reach
"Indeed, depletion of USP44 expression by RNAi increased the levels of H2Bub1 and decreased the activity of autophagy significantly, as the levels of LC3B II were decreased and the p62 levels were increased after USP44 RNAi."
28180298
USP44 affects Ubiquitin
| 4
USP44 inhibits Ubiquitin.
| 2
USP44 inhibits Ubiquitin. 2 / 2
| 2
reach
"USP44, USP17L2/DUB3, USP11, ZUFSP and POH1 loss promotes the excessive spreading of Ub at DSBs and concomitant excessive accumulation of 53BP1 [57–65]."
31769469
reach
"It has been reported that USP44 inhibits the proteasome dependent degradation of CCNB1 by hydrolyzing its ubiquitin chain [XREF_BIBR]."
28938551
USP44 activates Ubiquitin.
| 2
USP44 activates mutated Ubiquitin. 1 / 1
| 1
reach
"Similarly, four of the seven possible single lysine residue variants (K6, K29, K33, and K63) did not allow FOXP3 deubiquitination by USP44 co-expression compared to wild-type and other ubiquitin mutants."
32644293
USP44 activates Ubiquitin. 1 / 1
| 1
reach
"This approach allowed us to identify the ubiquitin linkage type targeted by USP44."
32644293
USP44 affects USP7
| 1 3
USP7 binds USP44. 3 / 3
| 1 2
reach
"The cooperation between USP44 and USP7 was also seen in human iTregs."
32644293
sparser
"Co‐IP experiments revealed that USP44 and USP7 associated with each other in a complex (Fig  xref A)."
32644293
sparser
"It has been reported that USP44 and USP7 bind to the OCT-3/4 promoter, but their roles in stem cell differentiation and cellular reprogramming should be further investigated [ xref ]."
32178477
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
USP44 affects RNF168
| 4
USP44 inhibits RNF168.
| 3
USP44 inhibits RNF168. 3 / 3
| 3
reach
"Furthermore, overexpression of USP44 impairs RNF168, 53BP1 and RAP80 foci, all of which can be directed to DSBs by ubiquitinated H2A."
32708614
reach
"On the other hand, we also found 13 DUBs that were recruited to DNA damage sites but gave only marginal DSB repair defects upon siRNA depletion, including OTUB1, a negative regulator of the UBE2N (UBC13) ubiquitin E2 enzyme 24, USP44 that is reported to antagonize RNF168 dependent ubiquitylation 25, and OTUB2 that functions in repair-pathway choice 26 (XREF_FIG, XREF_FIG, and XREF_FIG), suggesting that some of the additional DUBs we identified might be negative DDR regulators and/or be involved in repair-pathway choice."
25194926
reach
"Similar to USP26 and USP37, two other DUBs, USP3 and USP44, were shown to reverse RNF168 induced chromatin ubiquitylation, thereby controlling the accumulation of BRCA1 and 53BP1 at sites of DNA damage."
26101254
USP44 deubiquitinates RNF168.
| 1
USP44 deubiquitinates RNF168. 1 / 1
| 1
reach
"Recruitment of USP44 to DNA damage sites was shown to be dependent on RNF168 and it was suggested that USP44 binds to and deubiquitinates RNF8 and RNF168 dependent ubiquitination at DSB, though it is [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28624371
USP44 affects MAD2L1
1 | 3
USP44 deubiquitinates MAD2L1.
1 | 1
USP44 deubiquitinates MAD2L1. 2 / 2
1 | 1
reach
"Knocking down USP14 arrests cell cycle at the G2/M phase and inhibits the proliferation and migration of breast cancer cells, USP44 deubiquitinates the APC-inhibitory Mad2 and Cdc20 complex, thereby preventing anaphase onset."
33643919
ubibrowser
"USP39 deubiquitinates aurora B kinase maintaining spindle assembly checkpoint integrity [103] while USP44 stabilizes Mad2/Cdc20 complex inhibiting premature activation of the APC/CCdh1?complex"
25121098
USP44 activates MAD2L1.
| 2
USP44 activates MAD2L1. 2 / 2
| 2
reach
"In repeated experiments, we observed a modest but reproducible increase in the recovery of Mad2 with Cdc20, suggesting that excess Usp44 increases the association of Mad2 with Cdc20 (XREF_FIG)."
21853124
reach
"We find that high Usp44 promotes association of Mad2 with Cdc20 and reinforces the mitotic checkpoint."
21853124
USP44 affects JNK
| 4
USP44 inhibits JNK.
| 2
USP44 inhibits JNK. 2 / 2
| 2
reach
"We found that USP44 inhibited the JNK pathway but not the AKT, ERK or p38 pathways."
32164618
reach
"USP44 suppressed the JNK signaling pathway in ccRCC."
32164618
USP44 phosphorylates JNK.
| 1
USP44 phosphorylates JNK. 1 / 1
| 1
reach
"USP44 function in inhibiting the proliferation and migration of 786-O cells and Caki-1 cells was associated with phosphorylation of Jun N-terminal kinase (JNK)."
32164618
USP44 decreases the amount of JNK.
| 1
USP44 decreases the amount of JNK. 1 / 1
| 1
reach
"USP44 overexpression decreased the level of JNK, but not that of AKT, p38 or ERK, compared with control cells in both cell lines (Fig. 5a, b)."
32164618
TRIM25 affects USP44
| 1 3
TRIM25 binds USP44.
| 3
TRIM25 binds USP44. 3 / 3
| 3
sparser
"Truncation co-IP revealed that USP44 could interact with the HR1 and PRY/SPRY domains of TRIM25 but not the RING finger domain (Supplementary Fig.  xref ), suggesting that the HR1 and PRY/SPRY domains are important for the interaction between USP44 and TRIM25."
35079021
sparser
"However, we found that USP44-TRIM25 interaction could degrade Ku80 to inhibit NHEJ-mediated DNA, which combined with G2/M phase arrest and apoptosis induction to subsequently enhance radiosensitivity in NPC."
35079021
sparser
"To test whether NHEJ is the pathway affected by USP44, we performed the NHEJ report assay to see the effect of the USP44-TRIM25 axis on the NHEJ repair."
35079021
TRIM25 activates USP44.
| 1
TRIM25 activates USP44. 1 / 1
| 1
reach
"Knockout of TRIM25 reverses the radiotherapy sensitization effect of USP44."
35079021
DBH-AS1 affects USP44
| 1 3
DBH-AS1 activates USP44. 3 / 3
| 3
reach
"DBH-AS1 sequesters miR-3163 and thereby promotes USP44 upregulation."
35433957
reach
"These results suggested that DBH-AS1 can competitively binding to miR-3163 to sequester it and thereby promote USP44 upregulation."
35433957
reach
"Mechanistically, DBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering miR-3163 and thus upregulating USP44 in these tumor cells."
35433957
DBH-AS1 activates USP44. 1 / 1
| 1
eidos
"Mechanistically , DBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering miR-3163 and thus upregulating USP44 in these tumor cells ."
35433957
Trichostatin A affects USP44
3 |
Trichostatin A decreases the amount of USP44. 3 / 3
3 |
ctd
No evidence text available
24935251
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Bisphenol A affects USP44
3 |
Bisphenol A decreases the amount of USP44.
2 |
Bisphenol A decreases the amount of USP44. 2 / 2
2 |
ctd
No evidence text available
25181051
ctd
No evidence text available
30248606
Bisphenol A increases the amount of USP44.
1 |
Bisphenol A increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
29275510
XRCC5 affects USP44
| 3
XRCC5 binds USP44. 3 / 3
| 3
sparser
"First, we found that USP44 interacts with the Ku80 protein."
35079021
sparser
"Co-IP also verified the exogenous interaction between USP44 and Ku80 (Fig.  xref )."
35079021
sparser
"Therefore, we next sought to determine how the interaction between USP44 and Ku80 proteins affects radiosensitization in NPC."
35079021
USP44 inhibits cell differentiation. 2 / 3
| 2
reach
"For instance, two histone directed DUBs, USP44 and USP22, are antagonistically regulated in their mRNA expression to ensure faithful stem cell differentiation [XREF_BIBR - XREF_BIBR]."
33335288
reach
"USP44 depletion impairs differentiation and induction of RNF20 dependent genes."
22681888
USP44 affects XRCC5
| 3
XRCC5 binds USP44. 3 / 3
| 3
sparser
"First, we found that USP44 interacts with the Ku80 protein."
35079021
sparser
"Co-IP also verified the exogenous interaction between USP44 and Ku80 (Fig.  xref )."
35079021
sparser
"Therefore, we next sought to determine how the interaction between USP44 and Ku80 proteins affects radiosensitization in NPC."
35079021
USP44 affects TRIM25
| 3
TRIM25 binds USP44. 3 / 3
| 3
sparser
"Truncation co-IP revealed that USP44 could interact with the HR1 and PRY/SPRY domains of TRIM25 but not the RING finger domain (Supplementary Fig.  xref ), suggesting that the HR1 and PRY/SPRY domains are important for the interaction between USP44 and TRIM25."
35079021
sparser
"However, we found that USP44-TRIM25 interaction could degrade Ku80 to inhibit NHEJ-mediated DNA, which combined with G2/M phase arrest and apoptosis induction to subsequently enhance radiosensitivity in NPC."
35079021
sparser
"To test whether NHEJ is the pathway affected by USP44, we performed the NHEJ report assay to see the effect of the USP44-TRIM25 axis on the NHEJ repair."
35079021
USP44 affects TBLXR1
| 3
USP44 binds TBLXR1. 3 / 3
| 3
reach
"To determine whether USP44 interacts directly with TBLX1 or TBLXR1, we performed immunoprecipitation (IP) experiments using recombinant HA-USP44 and FLAG-TBL1X and TBL1XR1 from baculovirus infected insect cells."
27880911
reach
"Introduction of these constructs into 293T cells expressing FH-USP44 and subsequent FLAG-immunoprecipitations revealed that full length TBLXR1 and the C-terminal fragment interacted with USP44, but the N-terminal TBL1XR1 construct did not (XREF_FIG)."
27880911
reach
"To determine whether USP44 interacts directly with TBLX1 or TBLXR1, we performed IP experiments using recombinant HA-USP44 and FLAG-TBL1X and TBL1XR1 from baculovirus infected insect cells."
27880911
USP44 affects RNF20
| 2 1
USP44 binds RNF20.
| 1 1
RNF20 binds USP44. 1 / 1
| 1
reach
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
RNF20 binds RNF40 and USP44. 1 / 1
| 1
sparser
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
USP44 inhibits RNF20.
| 1
USP44 inhibits RNF20. 1 / 1
| 1
reach
"USP44 depletion impairs differentiation and induction of RNF20 dependent genes."
22681888
USP44 affects NCOR
| 2 1
USP44 activates NCOR.
| 2
USP44 activates NCOR. 2 / 2
| 2
reach
"Similarly, the deletion of USP44, an integral component of NCoR, impaired the ability of NCoR to regulate gene expression and suppressed breast cancer cell invasiveness [29]."
31565033
reach
"The N and CoR complex is a well documented co-repressor for unliganded nuclear receptors, and our data demonstrate that USP44 contributes to NCoR mediated repression of the PPARdelta target gene Angptl4."
27880911
USP44 binds NCOR.
| 1
NCOR binds USP44. 1 / 1
| 1
sparser
"We found that USP44 interacts with several components of the nuclear receptor co-repressor complex (hereafter N-CoR complex)."
27880911
USP44 affects EZH2
| 3
USP44 activates EZH2.
| 2
USP44 activates EZH2. 2 / 2
| 2
reach
"USP44 can induce the genesis of prostate cancer cells partly by stabilizing EZH2 [39]."
32164618
reach
"Taken together, our results suggest that USP44 promotes the tumorigenesis of prostate cancer cells partly by stabilizing EZH2 and that USP44 is a viable therapeutic target for treating EZH2 dependent cancers."
30622230
USP44 deubiquitinates EZH2.
| 1
USP44 deubiquitinates EZH2. 1 / 1
| 1
reach
"Another recent study found that USP44 deubiquitinates and stabilizes the expression an activity of the histone methyltransferase EZH2 in prostate tumor cells as well as oncogenic mutants of this epigenetic factor with pro tumor results."
32644293
USP44 affects DNA
| 3
USP44 methylates DNA. 3 / 3
| 3
sparser
"In this study, we examined for the first time USP44 promoter methylation in plasma cell-free DNA (cfDNA) of patients with prostate cancer (early stage n = 32, metastatic n = 39) and 10 healthy donors (HD)."
34572834
sparser
"We report for the first time that detection of USP44 promoter methylation in plasma cell free DNA provides significant prognostic information in metastatic prostate cancer."
34572834
sparser
"USP44 Promoter Methylation in Plasma Cell-Free DNA in Prostate Cancer."
34572834
USP44 affects CTNNB1
| 3
USP44 inhibits CTNNB1.
| 2
USP44 inhibits CTNNB1. 2 / 2
| 2
reach
"USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating Wnt and beta-catenin pathway via Axin1 deubiquitination."
32285989
reach
"We found that USP44 overexpression increased Axin1 protein while decreased beta-catenin, c-myc and Cyclin D1 proteins, suggesting that USP44 inhibited the activation of Wnt and beta-catenin pathway."
32285989
USP44 decreases the amount of CTNNB1.
| 1
Modified USP44 decreases the amount of CTNNB1. 1 / 1
| 1
reach
"Increased expression of USP44 results in increased expression of Axin1, and decreased expressions of beta-catenin, c-Myc, and Cyclin D1."
32486158
USP44 affects APC_C
| 1 1
USP44 inhibits APC_C.
| 1
USP44 inhibits APC_C. 1 / 2
| 1
reach
"Thus, Usp44 and Usp37 can restrict the activity of the major K11 specific ligase, the APC/C, in addition to deubiquitinating substrates modified with K11 linked chains."
21978762
USP44 binds APC_C.
| 1
APC_C binds WDR5 and USP44. 1 / 1
| 1
sparser
"Disrupting its ability to bind WIN motifs (WDR5 ΔWIN ) blocked association of WDR5 with APC/C and USP44, but not TBP ( xref ; xref - xref )."
32076268
USP44 affects APC
| 2 1
USP44 inhibits APC.
| 1
USP44 inhibits APC. 1 / 1
| 1
reach
"Interestingly, a groundbreaking study from Dr. Elledge 's group identified that the deubiquitinating enzyme USP44 (ubiquitin specific protease 44) prevents the premature activation of the APC through stabilization of the APC-inhibitory Mad2 and Cdc20 complex [XREF_BIBR]."
23151139
USP44 deubiquitinates APC.
| 1
USP44 deubiquitinates APC. 1 / 1
| 1
reach
"USP44 deubiquitinates the APC coactivator Cdc20 both in vitro and in vivo, and thereby directly counteracts the APC driven disassembly of Mad2-Cdc20 complexes (discussed in an accompanying paper)."
17443180
USP44 binds APC.
| 1
USP44 binds APC. 1 / 1
| 1
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
19571111
TBLXR1 affects USP44
| 3
USP44 binds TBLXR1. 3 / 3
| 3
reach
"To determine whether USP44 interacts directly with TBLX1 or TBLXR1, we performed immunoprecipitation (IP) experiments using recombinant HA-USP44 and FLAG-TBL1X and TBL1XR1 from baculovirus infected insect cells."
27880911
reach
"Introduction of these constructs into 293T cells expressing FH-USP44 and subsequent FLAG-immunoprecipitations revealed that full length TBLXR1 and the C-terminal fragment interacted with USP44, but the N-terminal TBL1XR1 construct did not (XREF_FIG)."
27880911
reach
"To determine whether USP44 interacts directly with TBLX1 or TBLXR1, we performed IP experiments using recombinant HA-USP44 and FLAG-TBL1X and TBL1XR1 from baculovirus infected insect cells."
27880911
H2Bub1 affects USP44
| 3
USP44 binds H2Bub1. 3 / 3
| 3
reach
"Interestingly, overexpression of linc-RA1 decreased the interaction between H2Bub1 and USP44 in M059J cells after IR, while knockdown of linc-RA1 increased the interaction between H2Bub1 and USP44 in M059K cells after IR."
32934196
reach
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
reach
"These results indicated that linc-RA1 could stabilize the level of H2Bub1 by inhibiting the interaction between H2Bub1 and USP44."
32934196
Valproic acid affects USP44
2 |
Valproic acid decreases the amount of USP44. 2 / 2
2 |
ctd
No evidence text available
24935251
ctd
No evidence text available
28001369
Phenylmercury acetate decreases the amount of USP44. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
MiR-143-3p affects USP44
| 2
MiR-143-3p increases the amount of USP44.
| 1
MiR-143-3p increases the amount of USP44. 1 / 1
| 1
reach
"XREF_BIBR The downregulation of miR-143-3p by circFoxo3 increased the level of USP44, which in turn promoted tumor cell proliferation."
33614239
MiR-143-3p activates USP44.
| 1
MiR-143-3p activates USP44. 1 / 1
| 1
reach
"Furthermore, miR-143-3p was confirmed to target ubiquitin specific peptidase 44 (USP44), a cell cycle related protein that participates in tumor progression and metastasis."
33614239
LncRNA DBH-AS1 affects USP44
| 2
LncRNA DBH-AS1 inhibits USP44.
| 1
LncRNA DBH-AS1 inhibits USP44. 1 / 1
| 1
reach
"Increased m6A modification of lncRNA DBH-AS1 suppresses pancreatic cancer growth and gemcitabine resistance via the miR-3163/USP44 axis."
35433957
LncRNA DBH-AS1 binds USP44.
| 1
USP44 binds lncRNA DBH-AS1. 1 / 1
| 1
reach
"Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA DBH-AS1, miR-3163 and USP44."
35433957
Circ-Foxo3 affects USP44
| 1 1
Circ-Foxo3 increases the amount of USP44.
| 1
Circ-Foxo3 increases the amount of USP44. 1 / 1
| 1
reach
"In light of the circRNA-miRNA-mRNA network, bioinformatics analysis revealed that circ-Foxo3 upregulates the expression of USP44, promoting the progression of GC, and sponges miR-143-3p, and the results were validated by RNA binding protein immunoprecipitation (RIP) assay, dual-luciferase reporter assay, and RNA pull-down assay."
33833780
Circ-Foxo3 activates USP44.
| 1
Circ-Foxo3 activates USP44. 1 / 1
| 1
eidos
"In light of the circRNA-miRNA-mRNA network , bioinformatics analysis revealed that circ-Foxo3 upregulates the expression of USP44 , promoting the progression of GC , and sponges miR-143-3p , and the results were validated by RNA-binding protein immunoprecipitation ( RIP ) assay , dual-luciferase reporter assay , and RNA pull-down assay ( Fang et al ., 2019 ; Ouyang et al ., 2019 ; Wang Z. et al ., 2019 ) ."
33833780
USP49 affects USP44
1 | 1
USP44 binds USP49. 1 / 1
1 |
biogrid
No evidence text available
19615732
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
reach
"The deubiquitinase Usp44 counteracts Ubch10 mediated ubiquitination of BubR1 and Mad2, and, accordingly, depletion of Usp44 abolishes SAC arrest even in the presence of normal checkpoint machinery."
27893964
USP44 activates meiotic spindle assembly checkpoint. 1 / 1
| 1
reach
"Although the precise mechanism (s) by which SAC requires phosphorylation is still unclear, it has been suggested that phosphorylation of Cdc20 and USP44 promotes SAC action XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
22692537
USP44 affects degradation
| 2
USP44 inhibits degradation. 2 / 2
| 2
sparser
"Moreover, Usp44 inhibits Cdc20 degradation and counteracts UbcH10 to decelerate the metaphase to anaphase transition [ xref ]."
19302711
sparser
"It has been reported that USP44 inhibits the proteasome-dependent degradation of CCNB1 by hydrolyzing its ubiquitin chain [ xref ]."
28938551
reach
"USP44 inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry."
23187126
reach
"Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint."
23187131
USP44 affects Wnt
| 2
USP44 inhibits Wnt. 2 / 2
| 2
reach
"USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating Wnt and beta-catenin pathway via Axin1 deubiquitination."
32285989
reach
"We found that USP44 overexpression increased Axin1 protein while decreased beta-catenin, c-myc and Cyclin D1 proteins, suggesting that USP44 inhibited the activation of Wnt and beta-catenin pathway."
32285989
USP44 affects USP49
1 | 1
USP44 binds USP49. 1 / 1
1 |
biogrid
No evidence text available
19615732
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
USP44 affects Treg gene
| 2
USP44 increases the amount of Treg gene.
| 1
USP44 increases the amount of Treg gene. 1 / 1
| 1
reach
"USP44 knockdown in Tregs decreased FOXP3 expression and disrupted patterns of Treg gene expression (i.e., suppression of IL-2 expression)."
32644293
USP44 decreases the amount of Treg gene.
| 1
USP44 decreases the amount of Treg gene. 1 / 1
| 1
reach
"USP44 knockdown in Tregs decreased FOXP3 expression and disrupted patterns of Treg gene expression (i.e., suppression of IL-2 expression)."
32644293
USP44 affects TP53BP1
| 2
USP44 inhibits TP53BP1. 2 / 2
| 2
reach
"Furthermore, overexpression of USP44 impairs RNF168, 53BP1 and RAP80 foci, all of which can be directed to DSBs by ubiquitinated H2A."
32708614
reach
"USP44, USP17L2/DUB3, USP11, ZUFSP and POH1 loss promotes the excessive spreading of Ub at DSBs and concomitant excessive accumulation of 53BP1 [57–65]."
31769469
USP44 affects TBLX1
| 2
USP44 binds TBLX1. 2 / 2
| 2
reach
"To determine whether USP44 interacts directly with TBLX1 or TBLXR1, we performed immunoprecipitation (IP) experiments using recombinant HA-USP44 and FLAG-TBL1X and TBL1XR1 from baculovirus infected insect cells."
27880911
reach
"To determine whether USP44 interacts directly with TBLX1 or TBLXR1, we performed IP experiments using recombinant HA-USP44 and FLAG-TBL1X and TBL1XR1 from baculovirus infected insect cells."
27880911
USP44 affects RNF40
| 1 1
RNF40 binds USP44. 1 / 1
| 1
reach
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
RNF20 binds RNF40 and USP44. 1 / 1
| 1
sparser
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
USP44 affects POU5F1
1 | 1
USP44 deubiquitinates POU5F1.
1 |
USP44 deubiquitinates POU5F1. 1 / 1
1 |
USP44 binds POU5F1.
| 1
USP44 binds POU5F1. 1 / 1
| 1
sparser
"These data imply a complex picture where regulating factors such as OCT4 may interact with other epigenetic mechanisms to regulate USP44 expression in PSCs and testes."
28520534
USP44 affects PCNA
| 2
USP44 increases the amount of PCNA.
| 1
USP44 increases the amount of PCNA. 1 / 1
| 1
reach
"In addition, USP44 accelerated the cell cycle progression, with boosted cyclinD and PCNA levels."
36483601
USP44 deubiquitinates PCNA.
| 1
USP44 leads to the deubiquitination of PCNA. 1 / 1
| 1
reach
"In undamaged cells, the deubiquitinating enzyme USP44 prevents PCNA ubiquitination and recruitment of error-prone DNA polymerases, and is proposed as a safeguard mechanism against the mutagenic effects of these polymerases."
20458729
USP44 affects Neoplasms
| 1 1
USP44 inhibits Neoplasms.
| 1
USP44 inhibits Neoplasms. 1 / 1
| 1
eidos
"These data reveal the requirement for highly regulated ubiquitin addition and removal in the recognition and repair of helix-distorting DNA damage and identify another mechanism by which USP44 protects genomic integrity and prevents tumors ."
33937266
USP44 activates Neoplasms.
| 1
USP44 activates Neoplasms. 1 / 1
| 1
reach
"These results suggest that USP44 may be a good biomarker to predict ccRCC progression.Some studies have suggested that USP44 overexpression promotes tumor development, whereas other studies have indicated that USP44 inhibits proliferation of tumor cells [10, 11, 25, 26]."
32164618
USP44 affects JADE1
| 2
USP44 increases the amount of JADE1. 2 / 2
| 2
reach
"According to that study, the activation of stem cell transcription factor OCT4 pathway upregulated JADE1 gene expression along with stem cell factors NANOG, PHC1, USP44 and SOX2 (Jung et al., 2010)."
27155521
reach
"According to that study, the activation of stem cell transcription factor OCT4 pathway upregulated JADE1 gene expression along with stem cell factors NANOG, PHC1, USP44 and SOX2 60."
27155521
USP44 affects IFN-I
| 1 1
USP44 activates IFN-I. 2 / 2
| 1 1
reach
"Among the DUBs that interact with STING, five members, namely CYLD, OTUD5, USP18 (also termed UBP43), USP20, and USP44, have been demonstrated to promote IFN-I production and antiviral responses."
34707613
eidos
"Among the DUBs that interact with STING , five members , namely CYLD , OTUD5 , USP18 ( also termed UBP43 ) , USP20 , and USP44 , have been demonstrated to promote IFN-I production and antiviral responses ."
34707613
USP44 affects Histone_H3
| 2
USP44 deubiquitinates Histone_H3. 2 / 2
| 2
reach
"Our results indicate that both the deubiquitination of histone H2B by USP44 and deacetylation of histone H3 by HDAC3 contribute to N-CoR-mediated transcriptional repression."
27880911
reach
"Our results indicate that both the deubiquitination of histone H2B by USP44 and deacetylation of histone H3 by HDAC3 contribute to N-CoR mediated transcriptional repression (XREF_FIG)."
27880911
USP44 affects HDAC3
2 |
USP44 binds HDAC3. 2 / 2
2 |
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
USP44 affects Glioma
| 2
USP44 activates Glioma. 2 / 2
| 2
reach
"However, Zou and colleagues showed that USP44 overexpression promotes the malignancy of glioma [12]."
32164618
reach
"In current study, overexpression of USP44 enhanced the malignancy of glioma by stabilizing tumor-promoter securing [12]."
32164618
USP44 affects Flag
| 2
USP44 binds Flag. 2 / 2
| 2
sparser
"To overcome this obstacle, we reconstituted immortalized Usp44 -/- MLF cells (iMLFs) with Flag-tagged USP44 (USP44-Flag) by retrovirus-mediated transduction."
31968013
sparser
"Here, HEK 293T cells carrying combinations of Flag‐USP44, MYC‐FOXP3, and either wild‐type or lysine‐mutant ubiquitin constructs were treated with MG132 (to stabilize levels of ubiquitinated proteins) prior to ubiquitin (His) pull‐down and immunoblot assessment of FOXP3 species."
32644293
USP44 affects FH
| 2
USP44 binds FH and NCOR1. 2 / 2
| 2
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( xref )."
27880911
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( Figure 1 C)."
27880911
USP44 affects FBP1
| 2
USP44 increases the amount of FBP1.
| 1
USP44 increases the amount of FBP1. 1 / 1
| 1
reach
"Importantly, we revealed USP44 promoted FBP1 deubiquitination to increase FBP1 protein expression in pancreatic cancer, which might be one of the underlying mechanisms of USP44 impeding the progression of pancreatic cancer."
31497353
USP44 deubiquitinates FBP1.
| 1
USP44 leads to the deubiquitination of FBP1. 1 / 1
| 1
reach
"Importantly, we revealed USP44 promoted FBP1 deubiquitination to increase FBP1 protein expression in pancreatic cancer, which might be one of the underlying mechanisms of USP44 impeding the progression of pancreatic cancer."
31497353
USP44 affects DNMT3B
| 2
USP44 binds DNMT3A and DNMT3B. 2 / 2
| 2
sparser
"The results showed that both DNMT3a and DNMT3b bound to the promoter region of the USP44 gene and that the binding was significantly decreased after starvation (Figure xref )."
28180298
sparser
"Furthermore, consistent with the results from human cell lines (Figure xref ), the methylation of the USP44 gene promoter in mESCs is also likely regulated by DNMT3a and DNMT3b, as our chromatin immunoprecipitation assay indicated that differentiation promotes the binding of both DNMT3a and DNMT3b to the USP44 gene promoter (Figure xref )."
28180298
USP44 affects Cyclin
| 2
Modified USP44 decreases the amount of Cyclin. 1 / 1
| 1
reach
"Increased expression of USP44 results in increased expression of Axin1, and decreased expressions of beta-catenin, c-Myc, and Cyclin D1."
32486158
USP44 decreases the amount of Cyclin. 1 / 1
| 1
reach
"USP44 knockdown inhibited P21 expression and upregulated expression of cyclin D1 (Fig. 4d, e)."
32164618
USP44 affects Cdc20-APC
| 2
USP44 ubiquitinates Cdc20-APC.
| 1
USP44 leads to the ubiquitination of Cdc20-APC. 1 / 1
| 1
reach
"Knockdown of USP44 in neurons dramatically increased the polyubiquitination of Cdc20 and centrosomal Cdc20-APC activity, confirming that endogenous USP44 deubiquitinates Cdc20 in neurons (XREF_FIG)."
19167333
USP44 deubiquitinates Cdc20-APC.
| 1
USP44 leads to the deubiquitination of Cdc20-APC. 1 / 1
| 1
reach
"USP44 knockdown increased Cdc20 polyubiquitination and centrosomal Cdc20-APC activity in neurons, and correspondingly promoted the elaboration of dendrites."
20195072
USP44 affects Carcinogenesis
| 1 1
USP44 inhibits Carcinogenesis. 2 / 2
| 1 1
eidos
"USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma ."
35079021
reach
"USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma."
35079021
USP44 affects CXCL8
| 2
USP44 increases the amount of CXCL8. 2 / 2
| 2
reach
"However, USP44 silencing induced spindle multipolarity, abated VM, reduced transendothelial migration, and consequently decreased IL6 and IL8 levels in breast CSCs."
26232424
reach
"Moreover, breast cancer stem cells with high levels of the ubiquitin-specific protease 44 (USP44) display centrosome amplification and increased IL-8 expression, which promotes vascularization and predicts aggressive behavior (Liu et al., 2015)."
30458137
USP44 affects CCNB1
| 2
USP44 activates CCNB1. 2 / 2
| 2
reach
"It has been reported that USP44 inhibits the proteasome dependent degradation of CCNB1 by hydrolyzing its ubiquitin chain [XREF_BIBR]."
28938551
reach
"Taken together, these data suggest that exogenous Usp44 leads to increased cyclin B1 in G2 and prophase."
21853124
TBLX1 affects USP44
| 2
USP44 binds TBLX1. 2 / 2
| 2
reach
"To determine whether USP44 interacts directly with TBLX1 or TBLXR1, we performed immunoprecipitation (IP) experiments using recombinant HA-USP44 and FLAG-TBL1X and TBL1XR1 from baculovirus infected insect cells."
27880911
reach
"To determine whether USP44 interacts directly with TBLX1 or TBLXR1, we performed IP experiments using recombinant HA-USP44 and FLAG-TBL1X and TBL1XR1 from baculovirus infected insect cells."
27880911
TBL1XR1 affects TBL1X
| 2
TBL1X binds USP44 and TBL1XR1. 2 / 2
| 2
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( xref )."
27880911
sparser
"Both TBL1X and TBL1XR1 interacted with USP44, alone and together ( Figure 2 A)."
27880911
SMAD affects USP44
| 2
SMAD inhibits USP44.
| 1
SMAD inhibits USP44. 1 / 1
| 1
reach
"In line with such a mechanism for USP44 induction in Tregs, and the findings obtained in our reporter system, T cells from mice genetically deficient in SMAD2 and SMAD3 fail to up-regulate USP44 under iTreg skewing conditions, and SMAD deficiency similarly abrogated USP44 up-regulation by iTregs (Fig XREF_FIG G)."
32644293
SMAD increases the amount of USP44.
| 1
SMAD increases the amount of USP44. 1 / 1
| 1
reach
"These findings strongly suggest that USP44 expression in Tregs is largely driven by TGF-beta and SMAD signaling."
32644293
RNF40 affects USP44
| 1 1
RNF40 binds USP44. 1 / 1
| 1
reach
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
RNF20 binds RNF40 and USP44. 1 / 1
| 1
sparser
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
RNF20 affects USP44
| 1 1
RNF20 binds USP44. 1 / 1
| 1
reach
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
RNF20 binds RNF40 and USP44. 1 / 1
| 1
sparser
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
NCOR1 affects FH
| 2
USP44 binds FH and NCOR1. 2 / 2
| 2
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( xref )."
27880911
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( Figure 1 C)."
27880911
HDAC3 affects USP44
2 |
USP44 binds HDAC3. 2 / 2
2 |
biogrid
No evidence text available
27880911
biogrid
No evidence text available
27880911
Flag affects USP44
| 2
USP44 binds Flag. 2 / 2
| 2
sparser
"To overcome this obstacle, we reconstituted immortalized Usp44 -/- MLF cells (iMLFs) with Flag-tagged USP44 (USP44-Flag) by retrovirus-mediated transduction."
31968013
sparser
"Here, HEK 293T cells carrying combinations of Flag‐USP44, MYC‐FOXP3, and either wild‐type or lysine‐mutant ubiquitin constructs were treated with MG132 (to stabilize levels of ubiquitinated proteins) prior to ubiquitin (His) pull‐down and immunoblot assessment of FOXP3 species."
32644293
FH affects USP44
| 2
USP44 binds FH and NCOR1. 2 / 2
| 2
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( xref )."
27880911
sparser
"These experiments confirmed interactions between endogenous N-CoR complex subunits and FH-USP44, but not another H2Bub1 DUB, USP22 ( Figure 1 C)."
27880911
DNMT3B affects DNMT3A
| 2
USP44 binds DNMT3A and DNMT3B. 2 / 2
| 2
sparser
"The results showed that both DNMT3a and DNMT3b bound to the promoter region of the USP44 gene and that the binding was significantly decreased after starvation (Figure xref )."
28180298
sparser
"Furthermore, consistent with the results from human cell lines (Figure xref ), the methylation of the USP44 gene promoter in mESCs is also likely regulated by DNMT3a and DNMT3b, as our chromatin immunoprecipitation assay indicated that differentiation promotes the binding of both DNMT3a and DNMT3b to the USP44 gene promoter (Figure xref )."
28180298
Zinc sulfate affects USP44
1 |
Zinc sulfate decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
16330358
Titanium dioxide affects USP44
1 |
Titanium dioxide increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
23557971
Silicon dioxide affects USP44
1 |
Silicon dioxide increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
25895662
Propanal affects USP44
1 |
Propanal increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
26079696
Modifications.FLAG-HA affects USP44
| 1
USP44 binds modifications.FLAG-HA. 1 / 1
| 1
reach
"Nuclear extracts were prepared as described previously (Gao et al., 2014) with modifications.FLAG-HA and USP44 complex was purified by FLAG-HA affinity purification from nuclear extracts, and the elut[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
MiR-3163 affects USP44
| 1
USP44 binds miR-3163. 1 / 1
| 1
reach
"Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA DBH-AS1, miR-3163 and USP44."
35433957
Lipopolysaccharide, E coli O55-B5 increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
24972896
Let-7b affects USP44
| 1
Let-7b activates USP44. 1 / 1
| 1
reach
"Specifically, let-7b is predicted to target USP44, USP42 and ATXN7L3 [XREF_FIG]."
28604753
Kojic acid affects USP44
1 |
Kojic acid decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
16595896
ctd
No evidence text available
17103032
Hydroperoxide affects USP44
1 |
Hydroperoxide increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
26846883
Hsa-miR-6835-3p affects USP44
1 |
Hsa-miR-6835-3p decreases the amount of USP44. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-5572 affects USP44
1 |
Hsa-miR-5572 decreases the amount of USP44. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-450a-2-3p affects USP44
1 |
Hsa-miR-450a-2-3p decreases the amount of USP44. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4422 affects USP44
1 |
Hsa-miR-4422 decreases the amount of USP44. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4275 affects USP44
1 |
Hsa-miR-4275 decreases the amount of USP44. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4260 affects USP44
1 |
Hsa-miR-4260 decreases the amount of USP44. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-335-5p affects USP44
1 |
Hsa-miR-335-5p decreases the amount of USP44. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Hsa-miR-1276 affects USP44
1 |
Hsa-miR-1276 decreases the amount of USP44. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Dorsomorphin affects USP44
1 |
Dorsomorphin decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
27188386
Cyclophosphamide hydrate decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
27281708
Cor affects USP44
| 1
Histone_H2B binds USP44 and cor. 1 / 1
| 1
sparser
"USP44 was also found to be a negative regulator of H2B ubiquitylation (Fuchs et al , xref ; Lan et al , xref ) by mainly associating with chromatin and forming a complex with N‐COR subunits in the nucleus."
32644293
Cisplatin affects USP44
1 |
Cisplatin increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
27594783
CircFOXO3 affects USP44
| 1
CircFOXO3 increases the amount of USP44. 1 / 1
| 1
reach
"All the data indicate that circFOXO3 promotes GC cell proliferation and migration by upregulating USP44 expression via targeting of miR-143-3p."
32445925
Bis(2-ethylhexyl) phthalate decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
31163220
Arsenic atom affects USP44
1 |
Arsenic atom methylates USP44. 1 / 1
1 |
ctd
No evidence text available
21291286
All-trans-retinoic acid decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
21934132
Abrine affects USP44
1 |
Abrine decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
31054353
XPC affects USP44
| 1
XPC binds USP44. 1 / 1
| 1
reach
"Based on our observation that USP44 binds the XPC partner centrin, we hypothesized that it played a role in NER."
33937266
WDR5 affects USP44
| 1
APC_C binds WDR5 and USP44. 1 / 1
| 1
sparser
"Disrupting its ability to bind WIN motifs (WDR5 ΔWIN ) blocked association of WDR5 with APC/C and USP44, but not TBP ( xref ; xref - xref )."
32076268
Vehicle Emissions affects USP44
1 |
Vehicle Emissions demethylates USP44. 1 / 1
1 |
ctd
No evidence text available
25560391
VSX1 affects USP44
1 |
VSX1 decreases the amount of USP44. 1 / 1
1 |
biopax:msigdb
No evidence text available
USP7 affects USP49
| 1
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
USP44
| 1
USP44 translocates to the membrane. 1 / 1
| 1
sparser
"Since MITA is a transmembrane protein [ xref , xref ], we further examined whether USP44 was recruited to membranes during HSV-1 infection."
31968013
USP44 affects viral life cycle
| 1
eidos
"Deficiency of USP44 results in accelerated degradation of MITA , impaired induction of type I IFNs and proinflammatory cytokines , and increased viral replication ."
31968013
USP44 affects tumourigenesis
| 1
USP44 activates tumourigenesis. 1 / 1
| 1
eidos
"For example , USP10 interacts with G3BP2 to block p53 signal transduction , leading to poor prognosis in prostate cancer [ 27 ] ; USP44 promotes the development of prostate cancer by stabilizing EZH2 [ 28 ] , and USP2a enhances c-Myc expression via microRNA-related regulation and thus promotes tumourigenesis [ 29 ] ."
33546726
USP44 affects transcription downstream effector induced HSV-1 infection transfected HSV120 THP-1 cells
| 1
USP44 activates transcription downstream effector induced HSV-1 infection transfected HSV120 THP-1 cells. 1 / 1
| 1
eidos
"qPCR experiments showed that USP44 but not USP44 ( C282A ) promoted transcription of downstream effector genes induced by HSV-1 infection or transfected HSV120 in THP-1 cells ( Fig 6B ) ."
31968013
USP44 affects transcription IFNB1 IFIT1 IL6 CXCL10
| 1
USP44 activates transcription IFNB1 IFIT1 IL6 CXCL10. 1 / 1
| 1
eidos
"qPCR experiments indicated that USP44 enhanced transcription of IFNB1 , IFIT1 , IL6 and CXCL10 genes in response to HSV-1 ( Fig 1C ) ."
31968013
reach
"USP44 suppressed the JNK signaling pathway in ccRCC."
32164618
USP44 affects sensitivity cells radiotherapy
| 1
USP44 activates sensitivity cells radiotherapy. 1 / 1
| 1
eidos
"USP44 enhances the sensitivity of NPC cells to radiotherapy in vitro and in vivo ."
35079021
USP44 affects prostate cancer tumorigenesis
| 1
USP44 activates prostate cancer tumorigenesis. 1 / 1
| 1
eidos
"USP44 promotes prostate cancer tumorigenesis by stabilizing EZH2 [ 27 ] ."
31133011
USP44 affects proinflammatory cytokines
| 1
USP44 inhibits proinflammatory cytokines. 1 / 1
| 1
eidos
"Deficiency of USP44 results in accelerated degradation of MITA , impaired induction of type I IFNs and proinflammatory cytokines , and increased viral replication ."
31968013
USP44 affects peptidase
| 1
USP44 inhibits peptidase. 1 / 1
| 1
reach
"We found that pretreatment of active USP44 in vitro, isolated from SAC arrested cells, with active 3F-Fcp1 substantially reduced USP44 ubiquitin peptidase activity, whereas pretreatment with the catalytic dead 3F-Fcp1-CD mutant had little effect (XREF_FIG)."
22692537
USP44 affects pdaC
| 1
USP44 inhibits pdaC. 1 / 1
| 1
reach
"USP44 inhibit tumor cells progression and regulated gemcitabine resistance in PDAC."
31497353
USP44 affects pathway
| 1
USP44 inhibits pathway. 1 / 1
| 1
sparser
"We found that USP44 inhibited the JNK pathway but not the AKT, ERK or p38 pathways."
32164618
USP44 affects overall survival patients
| 1
USP44 activates overall survival patients. 1 / 1
| 1
eidos
"In the study of lung cancer , the decrease of USP44 expression level improves the invasive ability of tumor cells and reduces the overall survival rate of patients ."
32266120
USP44 affects nocodazole
| 1
USP44 inhibits nocodazole. 1 / 1
| 1
reach
"Over-expression of Usp44 reduces mitotic slippage in nocodazole."
21853124
USP44 affects modifications.FLAG-HA
| 1
USP44 binds modifications.FLAG-HA. 1 / 1
| 1
reach
"Nuclear extracts were prepared as described previously (Gao et al., 2014) with modifications.FLAG-HA and USP44 complex was purified by FLAG-HA affinity purification from nuclear extracts, and the elut[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
USP44 affects migration
| 1
USP44 activates migration. 1 / 1
| 1
eidos
"All the data indicate that circFOXO3 promotes GC cell proliferation and migration by upregulating USP44 expression via targeting of miR-143-3p ."
32445925
USP44 affects migration breast cancer cells
| 1
USP44 inhibits migration breast cancer cells. 1 / 1
| 1
eidos
"Knocking down USP14 arrests cell cycle at the G2 / M phase and inhibits the proliferation and migration of breast cancer cells ( 55 ) , USP44 deubiquitinates the APC-inhibitory Mad2-Cdc20 complex , thereby preventing anaphase onset ( 57 , 58 ) ."
33643919
USP44 affects miR-3163
| 1
USP44 binds miR-3163. 1 / 1
| 1
reach
"Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA DBH-AS1, miR-3163 and USP44."
35433957
USP44 affects maintenance H2Bub1
| 1
USP44 inhibits maintenance H2Bub1. 1 / 1
| 1
eidos
"Knockdown of Usp44 results in the maintenance of H2Bub1 upon starvation and abolishes the change in expression of starvation-induced autophagy-related genes ."
30126257
USP44 affects luciferase reporter
| 1
USP44 deubiquitinates luciferase reporter. 1 / 1
| 1
reach
"As part of N-CoR, USP44 deubiquitinates H2B both in vivo and in vitro, and it contributes to N-CoR-mediated repression of target genes, including a genome integrated luciferase reporter (Vaquero et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
USP44 affects lncRNA DBH-AS1
| 1
USP44 binds lncRNA DBH-AS1. 1 / 1
| 1
reach
"Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA DBH-AS1, miR-3163 and USP44."
35433957
USP44 affects invasive tumor cells
| 1
USP44 inhibits invasive tumor cells. 1 / 1
| 1
eidos
"In the study of lung cancer , the decrease of USP44 expression level improves the invasive ability of tumor cells and reduces the overall survival rate of patients ."
32266120
USP44 affects interleukin
| 1
USP44 activates interleukin. 1 / 1
| 1
reach
"In BC, Liu et al. [35] reported that USP44 silencing induced spindle multipolarity, abated vasculogenic mimicry, reduced transendothelial migration and decreased interleukin‐6 and interleukin‐8 levels in BC stem cells."
34056873
USP44 affects innate immune responses DNA viruses
| 1
USP44 activates innate immune responses DNA viruses. 1 / 1
| 1
eidos
"USP44 acts at the level of MITA To investigate the mechanisms on how USP44 modulates innate immune responses to DNA viruses , we examined the effects of USP44 on activation of the IFNB promoter mediated by components of the DNA-triggered signaling pathways ."
31968013
reach
"USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA."
31968013
USP44 affects impaired induction IFNs
| 1
USP44 inhibits impaired induction IFNs. 1 / 1
| 1
eidos
"Deficiency of USP44 results in accelerated degradation of MITA , impaired induction of type I IFNs and proinflammatory cytokines , and increased viral replication ."
31968013
USP44 affects immune response
| 1
reach
"165 Mice with Treg specific USP44 deficiency display enhanced antitumor immunity, implicating USP44 as a potential target for cancer immunotherapy."
33436547
USP44 affects gene expression
| 1
reach
"Lan et al. [36] indicated that USP44 contributed to N‐CoR functions with respect to regulating gene expression and was required for the efficient invasiveness of TNBC cells."
34056873
USP44 affects gemcitabine
| 1
USP44 inhibits gemcitabine. 1 / 1
| 1
reach
"USP44 inhibit tumor cells progression and regulated gemcitabine resistance in PDAC."
31497353
USP44 activates double-strand break repair. 1 / 1
| 1
reach
"USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma."
35079021
USP44 affects development prostate cancer
| 1
USP44 activates development prostate cancer. 1 / 1
| 1
eidos
"For example , USP10 interacts with G3BP2 to block p53 signal transduction , leading to poor prognosis in prostate cancer [ 27 ] ; USP44 promotes the development of prostate cancer by stabilizing EZH2 [ 28 ] , and USP2a enhances c-Myc expression via microRNA-related regulation and thus promotes tumourigenesis [ 29 ] ."
33546726
USP44 affects deubiquitination MITA
| 1
USP44 activates deubiquitination MITA. 1 / 1
| 1
eidos
"We found that USP44 but not USP44 ( C282A ) caused deubiquitination of MITA ( Fig 7A ) ."
31968013
USP44 affects cytosolic DNA
| 1
USP44 activates cytosolic DNA. 1 / 1
| 1
eidos
"Conversely , USP44 deficiency suppressed cytosolic DNA - and DNA virus-triggered innate immune response ."
31968013
USP44 affects cor
| 1
Histone_H2B binds USP44 and cor. 1 / 1
| 1
sparser
"USP44 was also found to be a negative regulator of H2B ubiquitylation (Fuchs et al , xref ; Lan et al , xref ) by mainly associating with chromatin and forming a complex with N‐COR subunits in the nucleus."
32644293
USP44 affects cGAS-MITA-mediated activation IFNB NF-kappaB
| 1
USP44 activates cGAS-MITA-mediated activation IFNB NF-kappaB. 1 / 1
| 1
eidos
"As shown in S5A and S5B Fig , USP44 cooperated with USP20 or CYLD to further enhance cGAS-MITA-mediated activation of IFNB promoter , ISRE and NF-kappaB , as well as to further remove K48-linked polyubiquitin chains from MITA ( S5A and S5B Fig ) ."
31968013
USP44 affects bypass checkpoint
| 1
USP44 inhibits bypass checkpoint. 1 / 1
| 1
eidos
"USP44 has been identified as a DUB critical for spindle assembly checkpoint activity in RNAi screens , where USP44 depletion was found to cause bypass of this checkpoint [ 132 , 133 ] ."
23712866
USP44 affects autophagy-related
| 1
USP44 activates autophagy-related. 1 / 1
| 1
eidos
"Knockdown of Usp44 results in the maintenance of H2Bub1 upon starvation and abolishes the change in expression of starvation-induced autophagy-related genes ."
30126257
USP44 affects antiviral responses
| 1
USP44 activates antiviral responses. 1 / 1
| 1
eidos
"Among the DUBs that interact with STING , five members , namely CYLD , OTUD5 , USP18 ( also termed UBP43 ) , USP20 , and USP44 , have been demonstrated to promote IFN-I production and antiviral responses ."
34707613
USP44 affects anaphase-promoting complex
| 1
USP44 inhibits anaphase-promoting complex. 1 / 1
| 1
reach
"During mitosis, USP44 prevents the premature activation of the anaphase promoting complex (APC) by stabilizing the APC-inhibitory Mad2 and Cdc20 complex in spindle assembly checkpoint (SAC) 11."
28544703
USP44 affects anaphase onset
| 1
USP44 inhibits anaphase onset. 1 / 1
| 1
eidos
"Knocking down USP14 arrests cell cycle at the G2 / M phase and inhibits the proliferation and migration of breast cancer cells ( 55 ) , USP44 deubiquitinates the APC-inhibitory Mad2-Cdc20 complex , thereby preventing anaphase onset ( 57 , 58 ) ."
33643919
USP44 affects activation
| 1
USP44 inhibits activation. 1 / 1
| 1
sparser
"We found that USP44 overexpression increased Axin1 protein while decreased β-catenin, c-myc and Cyclin D1 proteins, suggesting that USP44 inhibited the activation of Wnt/β-catenin pathway."
32285989
USP44 affects XPC
| 1
XPC binds USP44. 1 / 1
| 1
reach
"Based on our observation that USP44 binds the XPC partner centrin, we hypothesized that it played a role in NER."
33937266
USP44 affects WDR5
| 1
APC_C binds WDR5 and USP44. 1 / 1
| 1
sparser
"Disrupting its ability to bind WIN motifs (WDR5 ΔWIN ) blocked association of WDR5 with APC/C and USP44, but not TBP ( xref ; xref - xref )."
32076268
USP44 affects USP44
| 1
USP44 bound to CTN activates USP44. 1 / 1
| 1
reach
"The binding of USP44 with centrin, together with the predominant nuclear localization of USP44, led us to question the potential role of USP44 in NER."
33937266
USP44 affects USP44 ubiquitin
| 1
USP44 inhibits USP44 ubiquitin. 1 / 1
| 1
reach
"We found that pretreatment of active USP44 in vitro, isolated from SAC arrested cells, with active 3F-Fcp1 substantially reduced USP44 ubiquitin peptidase activity, whereas pretreatment with the catalytic dead 3F-Fcp1-CD mutant had little effect (XREF_FIG)."
22692537
USP44 affects USP3
| 1
USP44 activates USP3. 1 / 1
| 1
reach
"Similarly to USP3, USP44 can target the most common H2AK119ub mark and displace RNF168 and 53BP1 from IRIF [60,61]."
26882840
USP44 affects USP25
| 1
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
USP44 affects UIMC1
| 1
USP44 inhibits UIMC1. 1 / 1
| 1
reach
"Furthermore, overexpression of USP44 impairs RNF168, 53BP1 and RAP80 foci, all of which can be directed to DSBs by ubiquitinated H2A."
32708614
USP44 affects Treg
| 1
USP44 activates Treg. 1 / 1
| 1
reach
"The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation."
32644293
USP44 affects TCOF1
1 |
TCOF1 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects TBL2
1 |
TBL2 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects SOX2
| 1
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
USP44 affects SARS2
1 |
SARS2 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects Radiotherapy
| 1
USP44 activates Radiotherapy. 1 / 1
| 1
eidos
"USP44 enhances the sensitivity of NPC cells to radiotherapy in vitro and in vivo ."
35079021
USP44 affects RNF8
| 1
USP44 deubiquitinates RNF8. 1 / 1
| 1
reach
"Recruitment of USP44 to DNA damage sites was shown to be dependent on RNF168 and it was suggested that USP44 binds to and deubiquitinates RNF8 and RNF168 dependent ubiquitination at DSB, though it is [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28624371
USP44 affects Proteasome
| 1
USP44 activates Proteasome. 1 / 1
| 1
reach
"It has been reported that USP44 inhibits the proteasome dependent degradation of CCNB1 by hydrolyzing its ubiquitin chain [XREF_BIBR]."
28938551
USP44 activates Precursor T-Cell Lymphoblastic Leukemia-Lymphoma. 1 / 1
| 1
reach
"Consistently, the in vivo study revealed that USP44 knockdown restricted the leukemic engraftments in the bone marrow and spleens and reduced the infiltration of T-ALL cells in the livers and lungs."
36483601
USP44 affects PSMC5
1 |
USP44 binds PSMC5. 1 / 1
1 |
biogrid
No evidence text available
27880911
USP44 affects PSMC4
1 |
USP44 binds PSMC4. 1 / 1
1 |
biogrid
No evidence text available
27880911
USP44 affects PSMC2
1 |
USP44 binds PSMC2. 1 / 1
1 |
biogrid
No evidence text available
27880911
USP44 affects PSMC1
1 |
USP44 binds PSMC1. 1 / 1
1 |
biogrid
No evidence text available
27880911
USP44 affects PROLIFERATION
| 1
USP44 inhibits PROLIFERATION. 1 / 1
| 1
trips
"USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating Wnt/beta-catenin pathway via Axin1 deubiquitination."
32285989
USP44 affects POLR2G
1 |
USP44 binds POLR2G. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects PHF6
| 1
PHF6 binds USP44. 1 / 1
| 1
sparser
"Moreover, the co-immunoprecipitation assay revealed that PHF6 binds neither RNF20/40 nor USP44 (Figure xref )."
| PMC
reach
"USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer."
32956592
USP44 affects NR1H2
| 1
USP44 bound to CTN activates NR1H2. 1 / 1
| 1
reach
"The binding of USP44 with centrin, together with the predominant nuclear localization of USP44, led us to question the potential role of USP44 in NER."
33937266
USP44 affects NCOR2
1 |
USP44 binds NCOR2. 1 / 1
1 |
biogrid
No evidence text available
27880911
USP44 affects MYC
| 1
Modified USP44 decreases the amount of MYC. 1 / 1
| 1
reach
"Increased expression of USP44 results in increased expression of Axin1, and decreased expressions of beta-catenin, c-Myc, and Cyclin D1."
32486158
USP44 affects MRPS21
1 |
MRPS21 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects MRPL53
1 |
MRPL53 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects MRPL40
1 |
MRPL40 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects MRPL23
1 |
MRPL23 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects MMP9
| 1
USP44 inhibits MMP9. 1 / 1
| 1
reach
"USP44 overexpression down-regulated expression of the mRNA and protein of MMP2 and MMP9 in 786-O cells and Caki-1 cells (Fig. 3e–h)."
32164618
USP44 affects MMP2
| 1
USP44 inhibits MMP2. 1 / 1
| 1
reach
"USP44 overexpression down-regulated expression of the mRNA and protein of MMP2 and MMP9 in 786-O cells and Caki-1 cells (Fig. 3e–h)."
32164618
USP44 affects KRR1
1 |
USP44 binds KRR1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP44 affects KLF8
| 1
USP44 activates KLF8. 1 / 1
| 1
reach
"Indeed, knockdown of cyclin D1 or re-expression of USP44 reversed the proliferation of T80 and KLF8 cells back to the levels of the Mock cells (XREF_FIG)."
23222713
USP44 affects KAT5
| 1
USP44 activates KAT5. 1 / 1
| 1
reach
"Indeed, we found that USP44 can promote the stability of TIP60 in a dose dependent manner."
32644293
USP44 affects K48
| 1
USP44 binds FOXP3 and K48. 1 / 1
| 1
reach
"USP44 interacts with and stabilizes FOXP3 by removing K48 linked ubiquitin modifications."
32644293
USP44 affects JUN_family
| 1
USP44 phosphorylates JUN_family. 1 / 1
| 1
reach
"USP44 function in inhibiting the proliferation and migration of 786-O cells and Caki-1 cells was associated with phosphorylation of Jun N-terminal kinase (JNK)."
32164618
USP44 affects IL6
| 1
USP44 increases the amount of IL6. 1 / 1
| 1
reach
"However, USP44 silencing induced spindle multipolarity, abated VM, reduced transendothelial migration, and consequently decreased IL6 and IL8 levels in breast CSCs."
26232424
USP44 affects Histone
| 1
USP44 leads to the deubiquitination of Histone-H2A. 1 / 1
| 1
reach
"USP44 promoted deubiquitination of histones H2A and H2B in vitro, localized to DNA damage foci, and inhibited the local formation of polyubiquitin chains at the sites of DNA damage."
24647359
USP44 affects HSV-1-induced transcription downstream effector various cell
| 1
USP44 activates HSV-1-induced transcription downstream effector various cell. 1 / 1
| 1
eidos
"Overexpression of USP44 increased cytosolic DNA - and DNA virus-triggered activation of downstream effector genes whereas knockdown of USP44 inhibited HSV-1-induced transcription of downstream effector genes in various cell types ."
31968013
USP44 affects HSV-1-induced phosphorylation TBK1 IRF3 IKKbeta p65
| 1
USP44 activates HSV-1-induced phosphorylation TBK1 IRF3 IKKbeta p65. 1 / 1
| 1
eidos
"Moreover , USP44 enhanced HSV-1-induced phosphorylation of TBK1 , IRF3 , IKKbeta and p65 ( Fig 1F ) ."
31968013
USP44 affects HSV-1-induced phosphorylation TBK1 IRF3 IKKbeta p65 cells
| 1
USP44 activates HSV-1-induced phosphorylation TBK1 IRF3 IKKbeta p65 cells. 1 / 1
| 1
eidos
"Knockdown of USP44 also reduced HSV-1-induced phosphorylation of TBK1 , IRF3 , IKKbeta and p65 in THP-1 cells ( Fig 2D ) ."
31968013
USP44 affects HCMV HSV120-induced transcription IFNB1 IFIT1 IL6 CXCL10
| 1
USP44 activates HCMV HSV120-induced transcription IFNB1 IFIT1 IL6 CXCL10. 1 / 1
| 1
eidos
"We found that knockdown of USP44 inhibited HCMV - and HSV120-induced transcription of IFNB1 , IFIT1 , IL6 and CXCL10 genes ( Fig 2E ) , but had no marked effects on SeV - or dsRNA mimic poly ( I :C ) - induced transcription of antiviral genes in HFFs ( Fig 2F ) ."
31968013
USP44 affects H2Bubi
| 1
USP44 increases the amount of H2Bubi. 1 / 1
| 1
reach
"Mechanistically, depletion of USP44 prior to the differentiation signal promotes H2Bubi expression; however, impairing the dynamic turnover of H2BK120ubinterferes with proper execution of the differentiation process 47."
31827076
USP44 affects H2BK120ub1
| 1
USP44 deubiquitinates H2BK120ub1. 1 / 1
| 1
reach
"As a central component of the nuclear receptor corepressor (NCoR) complex, USP44 has been shown to coordinate deubiquitination of H2BK120ub1 and transcriptional repression [157]."
32708614
USP44 affects H2BK120ub
| 1
USP44 deubiquitinates H2BK120ub. 1 / 1
| 1
reach
"Other major DUBs with specificity for histone H2AK119ub over H2BK120ub are BAP1 and USP16, while USP3, USP12, USP22, and USP44 deubiquitinate both H2AK119ub and H2BK120ub, as well as different non histone substrates [XREF_BIBR]."
32344625
USP44 affects H2BC21
1 |
USP44 deubiquitinates H2BC21. 1 / 1
1 |
ubibrowser
No evidence text available
USP44 affects H2BC1
1 |
H2BC1 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
27880911
USP44 affects H2AK119ub
| 1
USP44 deubiquitinates H2AK119ub. 1 / 1
| 1
reach
"Other major DUBs with specificity for histone H2AK119ub over H2BK120ub are BAP1 and USP16, while USP3, USP12, USP22, and USP44 deubiquitinate both H2AK119ub and H2BK120ub, as well as different non histone substrates [XREF_BIBR]."
32344625
USP44 affects H2AC20
1 |
USP44 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"Both USP44 and USP29 promoted efficient deubiquitylation of histone H2A"
23615962
USP44 affects H2AC17
1 |
USP44 deubiquitinates H2AC17. 1 / 1
1 |
USP44 affects GC
| 1
USP44 activates GC. 1 / 1
| 1
reach
"In light of the circRNA-miRNA-mRNA network, bioinformatics analysis revealed that circ-Foxo3 upregulates the expression of USP44, promoting the progression of GC, and sponges miR-143-3p, and the results were validated by RNA binding protein immunoprecipitation (RIP) assay, dual-luciferase reporter assay, and RNA pull-down assay."
33833780
USP44 affects GC cell
| 1
USP44 activates GC cell. 1 / 1
| 1
eidos
"All the data indicate that circFOXO3 promotes GC cell proliferation and migration by upregulating USP44 expression via targeting of miR-143-3p ."
32445925
USP44 affects FAM126A
| 1
USP44 methylates FAM126A. 1 / 1
| 1
reach
"In a meta-analysis of The Cancer Genome Atlas pan-cancer methylation database, we identified a CpG island in the USP44 promoter that is methylated specifically in HCC."
36016503
USP44 affects Deubiquitinase
| 1
USP44 phosphorylates Deubiquitinase. 1 / 1
| 1
reach
"Phosphorylation-dependent activation on another DUB, USP44, is also critical for cell cycle regulation by maintaining the spindle checkpoint assembly."
32512887
USP44 binds DBH and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA DBH-AS1, miR-3163 and USP44."
35433957
USP44 affects DNA virus-triggered
| 1
USP44 activates DNA virus-triggered. 1 / 1
| 1
eidos
"Knockdown of USP44 inhibits DNA virus-triggered signaling To confirm the role of endogenous USP44 in DNA virus-triggered signaling , we designed two pSuper-RNAi constructs which could efficiently knockdown the expression of USP44 ( Fig 2A ) ."
31968013
USP44 affects DNA virus-triggered innate immune response
| 1
USP44 activates DNA virus-triggered innate immune response. 1 / 1
| 1
eidos
"Conversely , USP44 deficiency suppressed cytosolic DNA - and DNA virus-triggered innate immune response ."
31968013
USP44 affects DNA virus-induced innate immune responses
| 1
USP44 activates DNA virus-induced innate immune responses. 1 / 1
| 1
eidos
"Knockdown of USP44 inhibits DNA virus-induced innate immune responses ."
31968013
USP44 affects DNA aneuploidy
| 1
USP44 activates DNA aneuploidy. 1 / 1
| 1
eidos
"USP44 also induces DNA aneuploidy in gastric cancer , which may induce cell cycle arrest and apoptosis [ 28 ] ."
31133011
reach
"Importantly, while USP44 overexpression is able to negatively regulate DSB repair factors, knockdown of this DUB only mildly impacts H2A ubiquitination levels and the response to DSBs [110]."
32708614
USP44 affects DBH
| 1
USP44 binds DBH and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA DBH-AS1, miR-3163 and USP44."
35433957
USP44 affects Cyclin_D
| 1
USP44 increases the amount of Cyclin_D. 1 / 1
| 1
reach
"In addition, USP44 accelerated the cell cycle progression, with boosted cyclinD and PCNA levels."
36483601
USP44 affects CoR
| 1
USP44 activates CoR. 1 / 1
| 1
reach
"USP44 within N-CoR deubiquitinates H2B in vitro and in vivo, and ablation of USP44 impairs the repressive activity of the N and CoR complex."
27880911
USP44 affects Cdc20 ubiquitination
| 1
USP44 inhibits Cdc20 ubiquitination. 1 / 1
| 1
eidos
"USP44 reverses Cdc20 ubiquitination , thereby preventing full activation of the APC / C and implicating USP44 as a component of the mitotic spindle checkpoint ."
32201366
USP44 affects Cdc20 MCC
| 1
USP44 leads to the deubiquitination of Cdc20 MCC. 1 / 1
| 1
reach
"Furthermore, USP44 catalyses Cdc20 MCC deubiquitination, thereby antagonizing Cdc20 MCC ubiquitination to stabilize the APC/C MCC, thus sustaining the SAC [XREF_BIBR]."
29167309
USP44 affects CRC
| 1
USP44 inhibits CRC. 1 / 1
| 1
reach
"Here, we found that USP44 expression level was markedly decreased in CRC, and USP44 overexpression inhibited proliferation while enhanced apoptosis in CRC cells, suggesting that USP44 is a cancer suppressor in CRC."
32285989
USP44 affects CDKN1A
| 1
USP44 increases the amount of CDKN1A. 1 / 1
| 1
reach
"USP44 knockdown inhibited P21 expression and upregulated expression of cyclin D1 (Fig. 4d, e)."
32164618
USP44 affects BCL2
| 1
USP44 activates BCL2. 1 / 1
| 1
reach
"The blot density of Bax increased, while the blot density of Bcl-2 decreased in both U251-USP44-KD2 cells and A172-USP44-KD2 cells, which means down-regulating USP44 increased the ratio of Bax and Bcl -2."
28938551
USP44 affects BAX
| 1
USP44 activates BAX. 1 / 1
| 1
reach
"The blot density of Bax increased, while the blot density of Bcl-2 decreased in both U251-USP44-KD2 cells and A172-USP44-KD2 cells, which means down-regulating USP44 increased the ratio of Bax and Bcl -2."
28938551
USP44 affects ANGPTL4
| 1
USP44 deubiquitinates ANGPTL4. 1 / 1
| 1
reach
"As part of N-CoR, USP44 deubiquitinates H2B both in vivo and in vitro, and it contributes to N-CoR-mediated repression of target genes, including a genome integrated luciferase reporter (Vaquero et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
USP44 affects A2B5
| 1
USP44 activates A2B5. 1 / 1
| 1
reach
"Indeed, just like RNF20 depletion, USP44 knockdown significantly attenuated the accumulation of A2B5 on the surface of RA treated cells (XREF_FIG)."
22681888
USP25 affects USP7
| 1
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
UBE2C affects USP44
| 1
UBE2C activates USP44. 1 / 1
| 1
reach
"The proposed mechanism for this activity involves antagonistic activities of the Ub E2 conjugating enzyme UbcH10 and USP44 in which UbcH10 promotes checkpoint silencing, and USP44 promotes checkpoint maintenance."
21853124
TCOF1 affects USP44
1 |
TCOF1 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
TBL2 affects USP44
1 |
TBL2 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
STAT2 affects USP44
1 |
STAT2 decreases the amount of USP44. 1 / 1
1 |
biopax:msigdb
No evidence text available
STAT1 affects USP44
1 |
STAT1 decreases the amount of USP44. 1 / 1
1 |
biopax:msigdb
No evidence text available
SRY affects USP44
1 |
SRY decreases the amount of USP44. 1 / 1
1 |
biopax:msigdb
No evidence text available
SOX2 affects USP7
| 1
SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
SARS2 affects USP44
1 |
SARS2 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
RNF40 affects RNF20
| 1
RNF20 binds RNF40 and USP44. 1 / 1
| 1
sparser
"Thus, we speculated that linc-RA1 might affect the interactions between H2Bub1 and RNF20, RNF40, or USP44."
32934196
PSMC5 affects USP44
1 |
USP44 binds PSMC5. 1 / 1
1 |
biogrid
No evidence text available
27880911
PSMC4 affects USP44
1 |
USP44 binds PSMC4. 1 / 1
1 |
biogrid
No evidence text available
27880911
PSMC2 affects USP44
1 |
USP44 binds PSMC2. 1 / 1
1 |
biogrid
No evidence text available
27880911
PSMC1 affects USP44
1 |
USP44 binds PSMC1. 1 / 1
1 |
biogrid
No evidence text available
27880911
POU5F1 affects USP44
| 1
USP44 binds POU5F1. 1 / 1
| 1
sparser
"These data imply a complex picture where regulating factors such as OCT4 may interact with other epigenetic mechanisms to regulate USP44 expression in PSCs and testes."
28520534
POLR2G affects USP44
1 |
USP44 binds POLR2G. 1 / 1
1 |
biogrid
No evidence text available
19615732
PHF6 affects USP44
| 1
PHF6 binds USP44. 1 / 1
| 1
sparser
"Moreover, the co-immunoprecipitation assay revealed that PHF6 binds neither RNF20/40 nor USP44 (Figure xref )."
| PMC
PCB 180 affects USP44
1 |
PCB 180 increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
25510870
NCOR2 affects USP44
1 |
USP44 binds NCOR2. 1 / 1
1 |
biogrid
No evidence text available
27880911
NCOR1 affects CETN2
| 1
CETN2 binds USP44 and NCOR1. 1 / 1
| 1
sparser
"Collectively, these results demonstrate that USP44 associates with the N-CoR complex independently of CETN2 in the nucleus, indicating that this DUB likely functions in multiple processes."
27880911
NCOR affects USP44
| 1
NCOR binds USP44. 1 / 1
| 1
sparser
"We found that USP44 interacts with several components of the nuclear receptor co-repressor complex (hereafter N-CoR complex)."
27880911
NANOG affects USP10, USP16, USP3, USP37, USP44, and USP7
| 1
USP10 binds USP16, USP3, USP7, USP37, USP44, and NANOG. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
MRPS21 affects USP44
1 |
MRPS21 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
MRPL53 affects USP44
1 |
MRPL53 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
MRPL40 affects USP44
1 |
MRPL40 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
MRPL23 affects USP44
1 |
MRPL23 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
19615732
Linc-RA1 affects USP44
| 1
Linc-RA1 activates USP44. 1 / 1
| 1
reach
"Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1 and USP44 combination in glioma cells."
32934196
KRR1 affects USP44
1 |
USP44 binds KRR1. 1 / 1
1 |
biogrid
No evidence text available
19615732
KLF8 affects USP44
| 1
KLF8 activates USP44. 1 / 1
| 1
reach
"Zhao et al reported that KLF8 promoted proliferation in the human ovarian cell by up-regulating CCND1 and down-regulating USP44 expression [XREF_BIBR]."
28938551
K48 affects USP44
| 1
USP44 binds FOXP3 and K48. 1 / 1
| 1
reach
"USP44 interacts with and stabilizes FOXP3 by removing K48 linked ubiquitin modifications."
32644293
JNK affects USP44
| 1
JNK inhibits USP44. 1 / 1
| 1
reach
"JNK activation in USP44 knockdown could have been a result of stress-response activation due to chromosome mis-segregation, as reported by Kumar and colleagues [38]."
32164618
JNK inhibitor affects USP44
| 1
JNK inhibitor increases the amount of USP44. 1 / 1
| 1
reach
"Rescue experiments showed that silencing USP44 expression to promote the proliferation and migration of tumor cells could be blocked by a JNK inhibitor."
32164618
IRF1 affects USP44
1 |
IRF1 decreases the amount of USP44. 1 / 1
1 |
biopax:msigdb
No evidence text available
Histone_H2B affects cor
| 1
Histone_H2B binds USP44 and cor. 1 / 1
| 1
sparser
"USP44 was also found to be a negative regulator of H2B ubiquitylation (Fuchs et al , xref ; Lan et al , xref ) by mainly associating with chromatin and forming a complex with N‐COR subunits in the nucleus."
32644293
H2BC1 affects USP44
1 |
H2BC1 binds USP44. 1 / 1
1 |
biogrid
No evidence text available
27880911
FOXP3 affects K48, and USP44
| 1
USP44 binds FOXP3 and K48. 1 / 1
| 1
reach
"USP44 interacts with and stabilizes FOXP3 by removing K48 linked ubiquitin modifications."
32644293
EZH2 affects USP44
| 1
EZH2 activates USP44. 1 / 1
| 1
reach
"We showed that EZH2 is a novel target of USP44 and that the protein stability of EZH2 is upregulated by USP44 mediated deubiquitination."
30622230
E2 affects USP44
| 1
E2 activates USP44. 1 / 1
| 1
reach
"The proposed mechanism for this activity involves antagonistic activities of the Ub E2 conjugating enzyme UbcH10 and USP44 in which UbcH10 promotes checkpoint silencing, and USP44 promotes checkpoint maintenance."
21853124
USP44 binds DBH and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA DBH-AS1, miR-3163 and USP44."
35433957
DDB2 affects USP44
| 1
USP44 binds DDB2. 1 / 1
| 1
reach
"The severe reduction of DDB2 accumulation kinetics at damage sites in living cells is most consistent with a direct effect of USP44 on chromatin bound DDB2 rather than enhanced recycling."
33937266
DBH affects USP44
| 1
USP44 binds DBH and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA DBH-AS1, miR-3163 and USP44."
35433957
CTDP1 affects USP44
| 1
CTDP1 dephosphorylates USP44. 1 / 1
| 1
sparser
"In vitro , active 3F-Fcp1 dephosphorylated mitotic Wee1, Cdc20 and USP44 but not Cdc27 ( xref )."
22692537
CETN2 affects NCOR1, and USP44
| 1
CETN2 binds USP44 and NCOR1. 1 / 1
| 1
sparser
"Collectively, these results demonstrate that USP44 associates with the N-CoR complex independently of CETN2 in the nucleus, indicating that this DUB likely functions in multiple processes."
27880911
AR affects USP44
1 |
AR decreases the amount of USP44. 1 / 1
1 |
biopax:msigdb
No evidence text available
APC_C affects WDR5
| 1
APC_C binds WDR5 and USP44. 1 / 1
| 1
sparser
"Disrupting its ability to bind WIN motifs (WDR5 ΔWIN ) blocked association of WDR5 with APC/C and USP44, but not TBP ( xref ; xref - xref )."
32076268
APC affects USP44
| 1
USP44 binds APC. 1 / 1
| 1
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
19571111
ANGPTL4 affects USP44
| 1
ANGPTL4 activates USP44. 1 / 1
| 1
reach
"Importantly, Angptl4 expression also was increased in Usp44 -null MEFs without or with ligand treatment compared with WT MEFs, indicating that USP44 is required for full repression of this N-CoR targe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27880911
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
21632981
17alpha-ethynylestradiol decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
23129252
1-phenylpropan-2-amine decreases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
30779732
2,4,5,2',5'-pentachlorobiphenyl increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
25510870
2,4,4'-trichlorobiphenyl increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
25510870
2,2',5,5'-tetrachlorobiphenyl increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
25510870
2,2',4,4',5,5'-hexachlorobiphenyl increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
25510870
2,2',3',4,4',5-hexachlorobiphenyl increases the amount of USP44. 1 / 1
1 |
ctd
No evidence text available
25510870