IndraLab

Statements

USP42 affects PPARG
| 37
PPARG binds USP42. 10 / 37
| 37
sparser
"Given the pivotal role of the USP42‐PPARγ axis in regulating liver regeneration, we have begun considering methods to target this molecular interplay as a basis for developing a novel therapeutic strategy."
40091484
sparser
"To activate the USP42‐PPARγ axis, it is essential to first induce the expression of USP42."
40091484
sparser
"More importantly, the USP42‐PPARγ axis can be activated by FGF2, which further guided us to establish a new extracellular vesicle‐based nanomedical strategy to target liver USP42‐PPARγ interaction and promote liver regeneration."
40091484
sparser
"FGF2 is An Activator for the USP42‐PPARγ Axis."
40091484
sparser
"The results described in the previous section raised the important question of whether the signaling factor upregulated USP42 levels and activated the USP42‐PPARγ axis during liver regeneration."
40091484
sparser
"Previous studies have shown that FGFs secreted by hepatocytes play a crucial role in mediating liver repair. [ xref ] Therefore, we speculated that FGFs activate the USP42‐PPARγ axis."
40091484
sparser
"The second step was to enhance the interaction between USP42 and PPARγ."
40091484
sparser
"To further determine whether FGF2 enhanced USP42‐PPARγ interaction, we performed Co‐IP in 293T and Hepa1‐6 cell models."
40091484
sparser
"Co‐IP assay demonstrated that TA indeed enhanced interaction between PPARγ and USP42 (Figure xref , Supporting Information)."
40091484
sparser
"To further confirm the regulatory role of the USP42‐PPARγ axis in liver repair, we used a specific PPARγ antagonist, GW9662, to inhibit PPARγ transcriptional activity in the presence of high USP42 expression 48 h after CCL4 treatment (Figure xref , Supporting Information)."
40091484
USP42 is modified
36 |
USP42 is phosphorylated on S856. 8 / 8
8 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18452278
hprd
No evidence text available
19413330
hprd
No evidence text available
19651622
hprd
No evidence text available
19664995
hprd
No evidence text available
19415658
hprd
No evidence text available
18669648
hprd
No evidence text available
17081983
USP42 is phosphorylated on S615. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19651622
hprd
No evidence text available
18669648
USP42 is phosphorylated on S754. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18452278
hprd
No evidence text available
19664995
USP42 is phosphorylated on S1226. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
hprd
No evidence text available
17081983
USP42 is phosphorylated on S1222. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP42 is phosphorylated on S1219. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP42 is phosphorylated on S612. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP42 is phosphorylated on S611. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP42 is phosphorylated on S1247. 1 / 1
1 |
hprd
No evidence text available
18452278
USP42 is phosphorylated on S832. 1 / 1
1 |
hprd
No evidence text available
20068231
USP42 is phosphorylated on S919. 1 / 1
1 |
hprd
No evidence text available
18452278
USP42 is phosphorylated on S936. 1 / 1
1 |
hprd
No evidence text available
19651622
USP42 is phosphorylated on S759. 1 / 1
1 |
hprd
No evidence text available
20068231
USP42 is phosphorylated on S1280. 1 / 1
1 |
hprd
No evidence text available
20068231
USP42 is phosphorylated on Y953. 1 / 1
1 |
hprd
No evidence text available
18691976
USP42 is phosphorylated on S483. 1 / 1
1 |
hprd
No evidence text available
18452278
USP42 is phosphorylated on S619. 1 / 1
1 |
hprd
No evidence text available
18669648
USP42 is phosphorylated on T772. 1 / 1
1 |
hprd
No evidence text available
20068231
USP42 is phosphorylated on S829. 1 / 1
1 |
hprd
No evidence text available
20068231
USP42 affects TP53
3 1 | 13 7
USP42 binds TP53.
3 | 3 6
USP42 binds TP53. 10 / 12
3 | 3 4
sparser
"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals including Dox [ xref ].."
24143256
sparser
"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals."
22085928
sparser
"Usp42 forms a direct complex with p53 and controls its activation in response to cellular stress; as a result it regulates p53-dependent transcription and cell cycle arrest."
25962961
reach
"It has been reported that USP42 interacts with and deubiquitinates p53."
24143256
biogrid
No evidence text available
22085928
reach
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
biogrid
No evidence text available
22085928
biogrid
No evidence text available
22085928
sparser
"USP42 interacts with p53 and dominates p53 ubiquitination in response to stress signals such as Dox [22] ."
28807825
reach
"When subjected to external pressure, ubiquitin-specific peptidase 42 (USP42) can bind to p53 and stabilize its protein by removing the ubiquitin chain."
36613989
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
USP42 deubiquitinates TP53.
1 | 6
USP42 deubiquitinates TP53. 7 / 7
1 | 6
reach
"This is accomplished by several deubiquitination enzymes including USP7 that deubiquitinates Mdm2 to stabilize p53 [XREF_BIBR] as well as USP10 and USP42 that can directly deubiquitinate p53 upon DNA damage [XREF_BIBR, XREF_BIBR]."
28208785
reach
"In the initial phases of a stress response, USP42 deubiquitinates p53 by forming a direct complex with p53."
29479529
reach
"It has been reported that USP42 interacts with and deubiquitinates p53."
24143256
reach
"P53 can be directly deubiquitinated by Usp42 which reverses its ubiquitination by MDM2 [XREF_BIBR]."
25962961
reach
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
ubibrowser
"28801249"
28801249
reach
"During the early phase of response to a stress signal, USP42 preferentially makes up a complex with and deubiquitinates p53, leading to the rapid activation of p53 for cell cycle arrest and p53-dependent transcription [55]."
| PMC
USP42 activates TP53.
| 4 1
USP42 activates TP53. 5 / 5
| 4 1
reach
"Although we do not find a clear role for USP42 in controlling either the basal or fully activated levels of p53, the function of USP42 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent cell-cycle arrest in response to stress."
22085928
reach
"Our previous work showed that USP42 can target p53 for deubiquitylation, with depletion of USP42 resulting in delays in stabilization of p53 and recruitment of p53 to target gene promoters."
25336640
reach
"USP42 itself was reported to increase the stability of p53 [XREF_BIBR]."
24646765
sparser
"Importantly though, USP42-dependent activation of p53 does not lead to apoptosis, suggesting that its main function is to contribute to the repair and recovery of cells from mild or transient damage."
32201366
reach
"Like USP10, USP42 is another p53-specific deubiquitinase and plays a role in DNA damage-induced p53 stabilization [84] ."
22673503
USP42 affects RUNX1
| 21
USP42 binds RUNX1. 10 / 21
| 21
sparser
"Segmental duplications (SDs), which are considered a common phenomenon and account for approximately 7% (or 218 Mbp) of the human genome [ xref ], have been reported to be associated with the formation of chimeric fusion genes, such as BCR::ABL1 through t(9;22)(q34;q11.2) [ xref ] and RUNX1::USP42 through ins(21;7)(q22;p15p22) [ xref ], in myeloid malignancies."
36011278
sparser
"In this latter patient (case 7), the recipient origin of the MS 171 months after the SCT was confirmed by the identification of an NF1 polymorphism in both pre‐ and post‐transplant samples, but the RUNX1::USP42 fusion in the MS could not be analyzed in the pre‐transplant BMB for technical reasons."
40906433
sparser
"Many of the remaining pediatric AML cases had structural variations leading to in-frame fusion events (e.g., MLLT10 fusions not with KMT2A or PICALM or RUNX1::USP42 ) 20.21 that likely drive AML, but that are not recurrent enough to warrant designation as a distinct molecular category without interrogating additional datasets."
39781610
sparser
"The remaining patients harbored already reported fusions that do not impact our current treatment protocols ( STIL::TAL1, RBM15::MKL1, PICALM::MLLT10 ) and novel fusions recently reported in the literature with potential or clinical impact in therapeutic protocols [ P2RY8::CRLF2, MEF2D::BCL9, MEF2D::CSF1R, ETV6::ABL1, TCF3::ZNF384, PAX5::NOL4L, RUNX1::CBFA2T3, RUNX1::USP42 , and TBL1XR1::TP63 ( xref )]."
35463953
sparser
"We detected a total of 86 genetic aberrations in 39 patients (87%), 4 gene fusions of KMT2A-SEPT9 , KMT2A-ELL, NUP98-NSD1 , and RUNX1-USP42 , and 82 somatic mutations in 20 genes."
35566503
sparser
"In the same line, some of the most recurrent fusion genes in pediatric leukemia were found in our cohort ( ETV6::RUNX1, STIL::TAL1, KMT2A -rearrangements, RUNX1::RUNX1T1, BCR::ABL1 ), as well as other novel rearrangements described, most of them associated with BCP-ALL B-other subtypes ( MEF2D::BCL9, MEF2D::CSF1R, ETV6::ABL1, TCF3::ZNF384, and PAX5::NOL4L ) or to rare and/or recent AML fusions reported in the literature ( RUNX1::CBFA2T3, RBM15::MKL1, RUNX1::USP42, and TBL1XR1::TP63 ) ( xref ; xref ; xref )."
35463953
sparser
"Whole-genome sequencing identified cytogenetically cryptic structural variants in 13 patients, including complex or cryptic chromosomal translocations involving the inv(16)(p13.1q22) fusion gene CBFB–MYH11 in 2 patients, the t(7;21) (p22;q22) fusion gene USP42–RUNX1 in 1 patient, and 10 rearrangements involving KMT2A , all of which were verified with the use of orthogonal methods ( xref and xref , xref , and xref in the xref )."
33704937
sparser
"The second case, t(7;21)(q22;q22), suspected as RUNX1::USP42 [ xref ], was detected in one patient with no detection in this specific case."
39001529
sparser
"Reverse transcription–polymerase chain reaction (RT-PCR) analysis of RNA from the three patients with a t(7;21) confirmed the presence of a RUNX1-USP42 fusion transcript within the der(7) ( Figure 2 A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22867997
sparser
"The patients in the remaining cluster, carried various nonrecurrent rearrangements, including BCL11B rearrangements (n=2), CBFB-MYH11 (n=2), ETV6-MECOM (n=1), KMT2A-MLLT10 (n=1), MECOM (n=1), NUP98-HOXA13 (n=1), SFPQ-ZFP36L2 (n=1), MED12-HOXA9 (n=1), PIM1-BRD1 (n=1), CBFA2T3-GLIS2 (n=1), PICALM-MLLT10 (n=1), RUNX1-USP42 (n=1)."
35899387
TP53 affects USP42
3 | 3 6
USP42 binds TP53. 10 / 12
3 | 3 4
sparser
"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals including Dox [ xref ].."
24143256
sparser
"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals."
22085928
sparser
"Usp42 forms a direct complex with p53 and controls its activation in response to cellular stress; as a result it regulates p53-dependent transcription and cell cycle arrest."
25962961
reach
"It has been reported that USP42 interacts with and deubiquitinates p53."
24143256
biogrid
No evidence text available
22085928
reach
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
biogrid
No evidence text available
22085928
biogrid
No evidence text available
22085928
sparser
"USP42 interacts with p53 and dominates p53 ubiquitination in response to stress signals such as Dox [22] ."
28807825
reach
"When subjected to external pressure, ubiquitin-specific peptidase 42 (USP42) can bind to p53 and stabilize its protein by removing the ubiquitin chain."
36613989
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
USP42 activates cell population proliferation. 8 / 8
| 2 6
reach
"To further explore the cellular mechanism underlying USP42 induced cell proliferation, the protein levels of cell cycle proteins were assessed."
27030989
reach
"Our in vitro findings showed that silencing of USP42 inhibited cell proliferation via inducing G0/G1 arrest and suppressed cell invasion via MMPs and EMT regulators."
27030989
eidos
"USP42 depletion hinders cell proliferation and alters nuclear speckle morphology After comparing different methodologies to deplete USP42 expression , we achieved the best efficiency using CRISPR / Cas9 although without complete knockout , instead obtaining reduction to ~ 50 % , likely due to one allele disruption ( Fig. 6A ) ."
33731873
reach
"In vitro analyses also demonstrated that USP42 silencing suppressed cell proliferation by inducing G /G arrest, and inhibited cellular invasion via matrix metalloprotease and epithelial-mesenchymal transition regulation."
31897112
reach
"Moreover, USP42 silencing in two GC cell lines, AGS and MKN-45, notably inhibited cell proliferation, but stimulated G1 phase arrest."
27030989
reach
"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."
34405018
eidos
"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size , TNM staging , lymph node metastasis , and OS rate of GC patients , while inhibition of USP42 can induce G0 / G1 block and suppress cell proliferation and invasion ( Hou et al ., 2016 ) ."
33791299
reach
"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size, TNM staging, lymph node metastasis, and OS rate of GC patients, while inhibition of USP42 can induce G0/G1 block and suppress cell proliferation and invasion."
33791299
sparser
"Our in vitro findings showed that silencing of USP42 inhibited cell proliferation via inducing G0/G1 arrest and suppressed cell invasion via MMPs and EMT regulators."
27030989
USP42 affects Histone_H2B
| 5 2
USP42 binds Histone_H2B.
| 1 2
USP42 binds Histone_H2B. 3 / 5
| 1 2
reach
"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."
25336640
sparser
"This was of particular interest because a proteomic analysis of USP42-binding proteins had shown association of USP42 with histone H2B and other components of the transcriptional machinery (not shown)."
25336640
sparser
"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."
25336640
USP42 deubiquitinates Histone_H2B.
| 2
USP42 deubiquitinates Histone_H2B. 2 / 2
| 2
reach
"Indeed, in vitro analysis showed that USP42 is able to efficiently deubiquitylate histone H2B (XREF_FIG, E and F)."
25336640
reach
"Interestingly, USP42 was also proposed to regulate transcription by deubiquitylating histone H2B [56]."
33731873
USP42 ubiquitinates Histone_H2B.
| 1
USP42 leads to the ubiquitination of Histone_H2B. 1 / 1
| 1
reach
"These results suggest that USP42 can specifically modulate the levels of H2B ubiquitylation in the first nucleosomes of the p21 coding sequences in response to p53 activation."
25336640
USP42 activates Histone_H2B.
| 1
USP42 activates Histone_H2B. 1 / 1
| 1
reach
"Results : USP42 targets histone H2B at promoters, leading to decreased ubiquitylation."
25336640
USP42 activates homologous recombination. 5 / 5
| 5
reach
"USP42 promotes HR by facilitating DNA-end resection."
32541651
reach
"To understand how USP42 promotes HR, the effects of USP42 depletion with siRNAs on various aspects of HR were investigated."
32541651
reach
"Depleting USP42 resulted in significantly reduced RAD51 foci formation, suggesting that USP42 functions upstream of RAD51 recruitment to DSB sites and promotes HR."
32541651
reach
"Furthermore, the deubiquitylation enzyme USP42, another component of nuclear speckle, also promotes HR [ 82 ]."
34182258
reach
"Altogether, these results indicated that USP42 promoted HR and cellular viability by facilitating DNA-end resection."
32541651
USP42 activates homologous recombination. 1 / 1
| 1
reach
"USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX9."
32541651
USP42 inhibits homologous recombination. 1 / 1
| 1
reach
"We have also performed a DR-GFP assay to investigate whether DHX9 over-expression can rescue the HR defect caused by USP42 depletion (Fig. S5E)."
32541651
USP42 affects ZNRF3
2 | 4
USP42 deubiquitinates ZNRF3.
| 3
USP42 deubiquitinates ZNRF3. 3 / 3
| 3
reach
"ZNRF3 deubiquitination by USP42 stabilizes its surface retention and functions to downregulate Fzds (Hao et al. 2012; Koo et al. 2012; Colozza and Koo 2021; Giebel et al. 2021)."
38383910
reach
"USP42 deubiquitinates RNF43 (ring finger protein 43) and ZNRF3 (zinc and ring finger 3), and USP42 knockout blocks Wnt activity[57]."
38292842
reach
"Once RNF43/ZNRF3 is internalized and no longer appears on the cell surface, it leaves FZDs available, resulting in enhanced Wnt signaling.Gieble et al. unmasked another piece in the puzzle of RNF43/ZNRF3 regulation [29] when they elegantly demonstrated that USP42 deubiquitinates RNF43/ZNRF3, thus negating the actions of the R-spondin–LGR5 axis."
39125653
USP42 binds ZNRF3.
2 |
USP42 binds ZNRF3. 2 / 2
2 |
biogrid
No evidence text available
33786993
biogrid
No evidence text available
33786993
USP42 activates ZNRF3.
| 1
USP42 activates ZNRF3. 1 / 1
| 1
reach
"69 Another DUB, USP42, prevents the ubiquitin‐mediated turnover of RNF43 and ZNRF3 to promote Wnt receptor degradation."
39520379
USP42 activates Neoplasm Invasiveness.
| 1 4
reach
"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size, TNM staging, lymph node metastasis, and OS rate of GC patients, while inhibition of USP42 can induce G0/G1 block and suppress cell proliferation and invasion."
33791299
reach
"In vitro and in vivo studies showed that USP42 knockdown inhibited GC cell survival and invasion, suggesting that USP42 may be a therapeutic target [62]."
36497313
reach
"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."
34405018
reach
"In vitro analyses also demonstrated that USP42 silencing suppressed cell proliferation by inducing G /G arrest, and inhibited cellular invasion via matrix metalloprotease and epithelial-mesenchymal transition regulation."
31897112
eidos
"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size , TNM staging , lymph node metastasis , and OS rate of GC patients , while inhibition of USP42 can induce G0 / G1 block and suppress cell proliferation and invasion ( Hou et al ., 2016 ) ."
33791299
USP42 inhibits Neoplasm Invasiveness. 1 / 1
| 1
reach
"The USP42 suppressed cells exhibited significantly less invasive potential than the siNC transfected cells (P < 0.01), suggesting that high expression of USP42 enhanced tumor invasiveness."
27030989
Histone_H2B affects USP42
| 2 2
Histone_H2B binds USP42.
| 1 2
USP42 binds Histone_H2B. 3 / 5
| 1 2
reach
"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."
25336640
sparser
"This was of particular interest because a proteomic analysis of USP42-binding proteins had shown association of USP42 with histone H2B and other components of the transcriptional machinery (not shown)."
25336640
sparser
"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."
25336640
Histone_H2B activates USP42.
| 1
Histone_H2B activates USP42. 1 / 1
| 1
reach
"Results : USP42 targets histone H2B at promoters, leading to decreased ubiquitylation."
25336640
Valproic acid affects USP42
5 |
Valproic acid decreases the amount of USP42.
4 |
Valproic acid decreases the amount of USP42. 4 / 4
4 |
ctd
No evidence text available
28001369
ctd
No evidence text available
26272509
ctd
No evidence text available
23179753
ctd
No evidence text available
27188386
Valproic acid methylates USP42.
1 |
Valproic acid methylates USP42. 1 / 1
1 |
ctd
No evidence text available
29154799
USP42 affects Wnt
| 2 3
USP42 inhibits Wnt.
| 2 2
USP42 inhibits Wnt. 4 / 4
| 2 2
reach
"USP42 protects ZNRF3 and RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling."
33786993
eidos
"Accordingly , USP42 increases the turnover of LRP6 and Frizzled ( FZD ) receptors and inhibits Wnt signalling ."
33786993
reach
"Accordingly, USP42 increases the turnover of LRP6 and Frizzled (FZD) receptors and inhibits Wnt signalling."
33786993
eidos
"We conclude that USP42 inhibits Wnt signalling in HCT116 cells by destabilising the Wnt receptors , independently of its roles in p53 response to genotoxic stress ."
33786993
USP42 activates Wnt.
| 1
USP42 activates Wnt. 1 / 1
| 1
reach
"USP42 deubiquitinates RNF43 (ring finger protein 43) and ZNRF3 (zinc and ring finger 3), and USP42 knockout blocks Wnt activity[57]."
38292842
USP42 affects RNF43
1 | 3 1
USP42 deubiquitinates RNF43.
| 2
USP42 deubiquitinates RNF43. 2 / 2
| 2
reach
"Once RNF43/ZNRF3 is internalized and no longer appears on the cell surface, it leaves FZDs available, resulting in enhanced Wnt signaling.Gieble et al. unmasked another piece in the puzzle of RNF43/ZNRF3 regulation [29] when they elegantly demonstrated that USP42 deubiquitinates RNF43/ZNRF3, thus negating the actions of the R-spondin–LGR5 axis."
39125653
reach
"USP42 deubiquitinates RNF43 (ring finger protein 43) and ZNRF3 (zinc and ring finger 3), and USP42 knockout blocks Wnt activity[57]."
38292842
USP42 binds RNF43.
1 | 1
USP42 binds RNF43. 2 / 2
1 | 1
sparser
"Additional co‐IP experiments revealed that USP42 also interacted with RNF43 (Fig  xref )."
33786993
biogrid
No evidence text available
33786993
USP42 activates RNF43.
| 1
USP42 activates RNF43. 1 / 1
| 1
reach
"69 Another DUB, USP42, prevents the ubiquitin‐mediated turnover of RNF43 and ZNRF3 to promote Wnt receptor degradation."
39520379
USP42 affects DHX9
| 2 3
USP42 binds DHX9.
| 1 3
USP42 binds DHX9. 4 / 4
| 1 3
sparser
"Furthermore, we established that USP42 interacts with DHX9, which possesses DNA–RNA helicase activity, and is required for efficient resolution of DSB-induced R-loop."
32541651
reach
"It is worth noting that the interaction between USP42 and DHX9 was independent of RNA and DNA, since immunoprecipitation was carried out in the presence of Benzonase (also see section “Materials and methods”)."
32541651
sparser
"It is worth noting that the interaction between USP42 and DHX9 was independent of RNA and DNA, since immunoprecipitation was carried out in the presence of Benzonase (also see section “Materials and methods”)."
32541651
sparser
"Firstly, we confirmed that USP42 interacted with DHX9 in a reciprocal manner by coimmunoprecipitation (Fig. xref )."
32541651
USP42 activates DHX9.
| 1
USP42 activates DHX9. 1 / 1
| 1
reach
"Similarly, the deubiquitinase USP42 promotes DHX9 activity towards R-loops at DSBs and is needed to recruit BRCA1 to break sites (Matsui et al., 2020)."
35508167
USP42 affects PLRG1
1 | 1 2
USP42 inhibits PLRG1.
| 1
USP42 inhibits PLRG1. 1 / 1
| 1
eidos
"Nevertheless , USP42 downregulation did not lead to significant changes in the expression levels of PLRG1 ( Supplementary Fig. 5C ) ."
33731873
USP42 increases the amount of PLRG1.
| 1
USP42 increases the amount of PLRG1. 1 / 1
| 1
reach
"Nevertheless, USP42 downregulation did not lead to significant changes in the expression levels of PLRG1 (Supplementary Fig.  5C)."
33731873
USP42 binds PLRG1.
1 |
USP42 binds PLRG1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 activates PLRG1.
| 1
USP42 activates PLRG1. 1 / 1
| 1
reach
"Notably, USP42 directs the integration of the spliceosome component PLRG1 into nuclear speckles, and its depletion interferes with the conformation of SC35 foci."
33731873
USP42 affects N
4 |
USP42 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP42 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP42 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP42 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP42 affects DVL
| 4
USP42 binds DVL. 4 / 4
| 4
sparser
"We also found that USP42 interacts with the Dishevelled interacting region (DIR) of ZNRF3."
33786993
sparser
"Mechanistically, USP42 interacts with the Dishevelled interacting region (DIR) of ZNRF3 and stalls the ZNRF3/LGR/RSPO complex."
33786993
sparser
"USP42 binds to the Dishevelled interacting region (DIR) of ZNRF3 and stalls the R‐spondin‐LGR4‐ZNRF3 ternary complex by deubiquitinating ZNRF3."
33786993
sparser
"Cytoplasmic USP42 binds the Dishevelled interacting region of ZNRF3."
33786993
reach
"USP42 depletion decreased the transcription of most of these target genes, although some (CASP1, PUMA, BAX, PIDD, and WIP1) were not affected (XREF_FIG G)."
25336640
reach
"To assess how the knockdown of USP42 induces a change in transcription from an endogenous promoter, we investigated the influence of USP42 reduction on the p21 promoter."
25336640
USP42 activates DNA-templated transcription. 2 / 2
| 2
reach
"Although we do not find a clear role for USP42 in controlling either the basal or fully activated levels of p53, the function of USP42 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent cell-cycle arrest in response to stress."
22085928
reach
"Again, we found three examples of genes that were not significantly affected by USP42 depletion (TAp73, FOXM1, and CCNE1), indicating that the requirement for USP42 to promote transcription is not universal."
25336640
N affects USP42
4 |
USP42 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP42 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP42 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP42 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
DVL affects USP42
| 4
USP42 binds DVL. 4 / 4
| 4
sparser
"We also found that USP42 interacts with the Dishevelled interacting region (DIR) of ZNRF3."
33786993
sparser
"Mechanistically, USP42 interacts with the Dishevelled interacting region (DIR) of ZNRF3 and stalls the ZNRF3/LGR/RSPO complex."
33786993
sparser
"USP42 binds to the Dishevelled interacting region (DIR) of ZNRF3 and stalls the R‐spondin‐LGR4‐ZNRF3 ternary complex by deubiquitinating ZNRF3."
33786993
sparser
"Cytoplasmic USP42 binds the Dishevelled interacting region of ZNRF3."
33786993
DHX9 affects USP42
| 1 3
USP42 binds DHX9. 4 / 4
| 1 3
sparser
"Furthermore, we established that USP42 interacts with DHX9, which possesses DNA–RNA helicase activity, and is required for efficient resolution of DSB-induced R-loop."
32541651
reach
"It is worth noting that the interaction between USP42 and DHX9 was independent of RNA and DNA, since immunoprecipitation was carried out in the presence of Benzonase (also see section “Materials and methods”)."
32541651
sparser
"It is worth noting that the interaction between USP42 and DHX9 was independent of RNA and DNA, since immunoprecipitation was carried out in the presence of Benzonase (also see section “Materials and methods”)."
32541651
sparser
"Firstly, we confirmed that USP42 interacted with DHX9 in a reciprocal manner by coimmunoprecipitation (Fig. xref )."
32541651
Hsa-mir-4770 affects USP42
3 |
Hsa-mir-4770 decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-mir-4503 affects USP42
3 |
Hsa-mir-4503 decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-mir-4310 affects USP42
3 |
Hsa-mir-4310 decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-mir-3686 affects USP42
3 |
Hsa-mir-3686 decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-7157-5p affects USP42
3 |
Hsa-miR-7157-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6838-5p affects USP42
3 |
Hsa-miR-6838-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6792-5p affects USP42
3 |
Hsa-miR-6792-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6731-3p affects USP42
3 |
Hsa-miR-6731-3p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6088 affects USP42
3 |
Hsa-miR-6088 decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-497-5p affects USP42
3 |
Hsa-miR-497-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4708-5p affects USP42
3 |
Hsa-miR-4708-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4482-3p affects USP42
3 |
Hsa-miR-4482-3p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-424-5p affects USP42
3 |
Hsa-miR-424-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3607-3p affects USP42
3 |
Hsa-miR-3607-3p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-26a-2-3p affects USP42
3 |
Hsa-miR-26a-2-3p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-26a-1-3p affects USP42
3 |
Hsa-miR-26a-1-3p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-195-5p affects USP42
3 |
Hsa-miR-195-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-16-5p affects USP42
3 |
Hsa-miR-16-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-15b-5p affects USP42
3 |
Hsa-miR-15b-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-15a-5p affects USP42
3 |
Hsa-miR-15a-5p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-143-3p affects USP42
3 |
Hsa-miR-143-3p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1273f affects USP42
3 |
Hsa-miR-1273f decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-103a-3p affects USP42
3 |
Hsa-miR-103a-3p decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
Bisphenol A affects USP42
3 |
Bisphenol A increases the amount of USP42. 3 / 3
3 |
ctd
No evidence text available
34947998
ctd
No evidence text available
32528016
ctd
No evidence text available
30816183
USP42 affects paracrine Wnt
| 3
USP42 inhibits paracrine Wnt. 3 / 3
| 3
eidos
"Taken together we concluded that Usp42 inhibits paracrine Wnt signalling in mouse small intestinal organoids ."
33786993
eidos
"USP42 inhibits paracrine Wnt signalling in RKO cells A B C D Immunofluorescence microscopy showing endogenous E-cadherin levels in RKO cells upon transfection with siUSP42 ."
33786993
eidos
"USP42 inhibits paracrine Wnt signalling in colorectal cancer cells A B C D E , F qPCR analysis of USP42 , LGR5 and AXIN2 expression levels in HCT116 cells ."
33786993
USP42 activates epithelial to mesenchymal transition. 2 / 2
| 2
reach
"In vitro analyses also demonstrated that USP42 silencing suppressed cell proliferation by inducing G /G arrest, and inhibited cellular invasion via matrix metalloprotease and epithelial-mesenchymal transition regulation."
31897112
reach
"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."
34405018
USP42 inhibits epithelial to mesenchymal transition. 1 / 1
| 1
eidos
"We conclude that USP42 prevents EMT in HCT116 cells by inhibiting paracrine Wnt signalling ."
33786993
USP42 affects USP42
| 2
USP42 increases the amount of USP42.
| 1
USP42 increases the amount of USP42. 1 / 2
| 1
reach
"These results suggested that TRIM21 not only gets deubiquitinated and stabilized by USP42 but in a positive feed-back loop also increases USP42 levels."
35779335
USP42 decreases the amount of USP42.
| 1
USP42 decreases the amount of USP42. 1 / 1
| 1
reach
"USP42 siRNA suppressed USP42 expression."
27030989
USP42 affects MMP
| 3
USP42 increases the amount of MMP.
| 1
USP42 increases the amount of MMP. 1 / 1
| 1
reach
"In gastric cancer cells, USP42 is regarded as an invasion promotor since the evidence showed that silencing of USP42 upregulated the expression of the E-cadherin, and downregulated the expression of MMPs, beta-catenin, Twist, and Snail1."
28279784
USP42 decreases the amount of MMP.
| 1
USP42 decreases the amount of MMP. 1 / 1
| 1
reach
"In gastric cancer cells, USP42 is regarded as an invasion promotor since the evidence showed that silencing of USP42 upregulated the expression of the E-cadherin, and downregulated the expression of MMPs, beta-catenin, Twist, and Snail1."
28279784
USP42 activates MMP.
| 1
USP42 activates MMP. 1 / 1
| 1
reach
"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."
34405018
USP42 affects LRP6
| 3
USP42 ubiquitinates LRP6.
| 1
USP42 leads to the ubiquitination of LRP6. 1 / 1
| 1
reach
"In this way USP42 antagonizes RSPOs by protecting ZNRF3/RNF43 from RSPO- and ubiquitin-dependent internalization, thereby increasing the ubiquitylation and turnover of FZD and LRP6 receptors, and inhibiting WNT signaling."
35817504
USP42 inhibits LRP6.
| 1
USP42 inhibits LRP6. 1 / 1
| 1
reach
"Consequently, USP42 increases the turnover of Frizzled and LRP6 and diminishes WNT signaling in CRC cells and mouse intestinal organoids [73]."
34071313
USP42 activates LRP6.
| 1
USP42 activates LRP6. 1 / 1
| 1
reach
"Accordingly, USP42 increases the turnover of LRP6 and Frizzled (FZD) receptors and inhibits Wnt signalling."
33786993
USP42 affects Histone
| 2 1
USP42 deubiquitinates Histone.
| 1
USP42 deubiquitinates Histone. 1 / 1
| 1
reach
"USP42 has been shown to play very important roles in transcription, where it functions to deubiquitylate histones to regulate transcription."
37628680
USP42 binds Histone.
| 1
Histone binds USP42. 1 / 1
| 1
sparser
"A previous proteomic analysis of the DUB interactome described an association of USP42 with histones, but also with a large number of other proteins, including other DUBs ( xref )."
25336640
USP42 activates Histone.
| 1
USP42 activates Histone. 1 / 1
| 1
reach
"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."
25336640
MIR107 affects USP42
3 |
MIR107 decreases the amount of USP42. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
20371350
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP42.
2 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP42. 2 / 2
2 |
ctd
No evidence text available
25270620
ctd
No evidence text available
17942748
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP42.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
34747641
Trichostatin A affects USP42
2 |
Trichostatin A decreases the amount of USP42. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Thiram affects USP42
2 |
Thiram increases the amount of USP42.
1 |
Thiram increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
38568856
Thiram decreases the amount of USP42.
1 |
Thiram decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
20530235
Hsa-miR-627-5p affects USP42
2 |
Hsa-miR-627-5p decreases the amount of USP42. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Cyclosporin A affects USP42
2 |
Cyclosporin A increases the amount of USP42. 2 / 2
2 |
ctd
No evidence text available
25562108
ctd
No evidence text available
20106945
ZNRF3 affects USP42
2 |
USP42 binds ZNRF3. 2 / 2
2 |
biogrid
No evidence text available
33786993
biogrid
No evidence text available
33786993
USP7 affects USP42
| 2
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
USP42 affects cell growth
| 1 1
USP42 activates cell growth. 2 / 2
| 1 1
reach
"Depletion of USP42 leads to a reduced number of nuclear speckles and attenuated cell growth."
33731873
eidos
"Depletion of USP42 leads to a reduced number of nuclear speckles and attenuated cell growth ."
33731873
USP42 affects USP7
| 2
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
USP42 affects TRIM21
| 1 1
USP42 deubiquitinates TRIM21.
| 1
USP42 deubiquitinates TRIM21. 1 / 1
| 1
reach
"These results suggested that TRIM21 not only gets deubiquitinated and stabilized by USP42 but in a positive feed-back loop also increases USP42 levels."
35779335
USP42 binds TRIM21.
| 1
TRIM21 binds USP42. 1 / 1
| 1
sparser
"Since neuroinflammation is a major manifestation during JEV infection in CNS, we checked whether USP42-TRIM21 axis can have any influence on inflammatory cytokine expression levels."
35779335
USP42 affects Stomach Neoplasms
| 1 1
USP42 binds Stomach Neoplasms. 1 / 1
| 1
sparser
"Further clinical characteristics analysis showed that expression level of USP42 was associated with overall survival of GC patients."
27030989
USP42 activates Stomach Neoplasms.
| 1
USP42 activates Stomach Neoplasms. 1 / 1
| 1
reach
"In vitro and in vivo studies showed that USP42 knockdown inhibited GC cell survival and invasion, suggesting that USP42 may be a therapeutic target [62]."
36497313
USP42 affects SIRT7
| 2
SIRT7 binds USP42. 2 / 2
| 2
sparser
"miR-21-5p, on the other hand, promotes sorafenib resistance and Hepatocellular Carcinoma (HCC) progression by upregulating autophagy through the USP42-SIRT7 axis [ xref ]."
40355722
sparser
"In hepatocellular carcinoma (HCC), miR-21-5p promotes sorafenib resistance and autophagy through the USP42-SIRT7 axis [ xref ]."
40355722
USP42 affects NPPA
| 2
NPPA binds USP42. 2 / 2
| 2
sparser
"According to the values established in the USP42-NF 37, all the batches of co-processed excipients showed excellent flow with values of 24–32°."
| PMC
sparser
"The method was adapted from USP monograph method ( USP42-NF37, 2019 )."
32795488
USP42 affects MMP9
1 | 1
USP42 increases the amount of MMP9.
| 1
USP42 increases the amount of MMP9. 1 / 1
| 1
reach
"As shown in XREF_FIG, silencing of USP42 downregulated the expression of MMP-2 and MMP-9."
27030989
USP42 deubiquitinates MMP9.
1 |
USP42 deubiquitinates MMP9. 1 / 1
1 |
USP42 affects JMJD6
2 |
JMJD6 binds USP42. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP42 inhibits Group I intron splicing. 1 / 1
| 1
reach
"Functionally, USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth, which is consistent with the impact of PLRG1 repression."
33731873
reach
"One example is the human USP42, which drives nuclear speckle phase separation dependent on its de-ubiquitinating activity, thus governing mRNA splicing events (Liu et al., 2021)."
34291086
USP42 affects FZD
| 2
USP42 ubiquitinates FZD.
| 1
USP42 leads to the ubiquitination of FZD. 1 / 1
| 1
reach
"In this way USP42 antagonizes RSPOs by protecting ZNRF3/RNF43 from RSPO- and ubiquitin-dependent internalization, thereby increasing the ubiquitylation and turnover of FZD and LRP6 receptors, and inhibiting WNT signaling."
35817504
USP42 activates FZD.
| 1
USP42 activates FZD. 1 / 1
| 1
reach
"Accordingly, USP42 increases the turnover of LRP6 and Frizzled (FZD) receptors and inhibits Wnt signalling."
33786993
USP42 affects EGFR
| 2
EGFR binds USP42. 1 / 1
| 1
sparser
"EGFR fusions are rare genomic events in NSCLC, and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3 and EGFR-ZCCHC6."
34342091
USP42 binds YAP1 and EGFR. 1 / 1
| 1
sparser
"EGFR fusions are rare genomic events in NSCLC, and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3 and EGFR-ZCCHC6."
34342091
USP42 affects CDKN1A
| 2
USP42 increases the amount of CDKN1A. 2 / 2
| 2
reach
"As we had demonstrated before, USP42 knockdown lowers p21 transcription at the early time points of p53 induction as a reflection of the reduced levels of p53."
25336640
reach
"For example, USP36 promotes transcriptional repression of Cyclin Dependent Kinase Inhibitor 1A ( CDKN1A ; also known as P21 ) by removing H2Bub1 specifically within the transcribed region, while USP42[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34953650
USP42 affects AHCYL1
2 |
USP42 binds AHCYL1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
33961781
USP10 affects USP7
| 2
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
Tobacco Smoke Pollution increases the amount of USP42. 2 / 2
2 |
ctd
No evidence text available
33660061
ctd
No evidence text available
28065790
TRIM21 affects USP42
| 1 1
TRIM21 binds USP42.
| 1
TRIM21 binds USP42. 1 / 1
| 1
sparser
"Since neuroinflammation is a major manifestation during JEV infection in CNS, we checked whether USP42-TRIM21 axis can have any influence on inflammatory cytokine expression levels."
35779335
TRIM21 activates USP42.
| 1
TRIM21 activates USP42. 1 / 1
| 1
reach
"This TRIM21 mediated induction of USP42 can downstream add to the stabilization of OAS1 which we established in previous results ( Fig. 6 A)."
35779335
TP53 affects USP7
| 2
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
SIRT7 affects USP42
| 2
SIRT7 binds USP42. 2 / 2
| 2
sparser
"miR-21-5p, on the other hand, promotes sorafenib resistance and Hepatocellular Carcinoma (HCC) progression by upregulating autophagy through the USP42-SIRT7 axis [ xref ]."
40355722
sparser
"In hepatocellular carcinoma (HCC), miR-21-5p promotes sorafenib resistance and autophagy through the USP42-SIRT7 axis [ xref ]."
40355722
RNF43 affects USP42
1 | 1
USP42 binds RNF43. 2 / 2
1 | 1
sparser
"Additional co‐IP experiments revealed that USP42 also interacted with RNF43 (Fig  xref )."
33786993
biogrid
No evidence text available
33786993
NPPA affects USP42
| 2
NPPA binds USP42. 2 / 2
| 2
sparser
"According to the values established in the USP42-NF 37, all the batches of co-processed excipients showed excellent flow with values of 24–32°."
| PMC
sparser
"The method was adapted from USP monograph method ( USP42-NF37, 2019 )."
32795488
MIR924 affects USP42
2 |
MIR924 decreases the amount of USP42. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
JMJD6 affects USP42
2 |
JMJD6 binds USP42. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EGFR affects USP42
| 2
EGFR binds USP42. 1 / 1
| 1
sparser
"EGFR fusions are rare genomic events in NSCLC, and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3 and EGFR-ZCCHC6."
34342091
USP42 binds YAP1 and EGFR. 1 / 1
| 1
sparser
"EGFR fusions are rare genomic events in NSCLC, and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3 and EGFR-ZCCHC6."
34342091
AHCYL1 affects USP42
2 |
USP42 binds AHCYL1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
33961781
17alpha-ethynylestradiol increases the amount of USP42.
1 |
17alpha-ethynylestradiol increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
17942748
17alpha-ethynylestradiol decreases the amount of USP42.
1 |
17alpha-ethynylestradiol decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
23129252
Urethane affects USP42
1 |
Urethane increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
28818685
Tungsten affects USP42
1 |
Tungsten decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
30912803
Triticonazole affects USP42
1 |
Triticonazole decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
36084822
Triphenyl phosphate decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
30864794
Torcetrapib affects USP42
1 |
Torcetrapib increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
23228038
Titanium dioxide affects USP42
1 |
Titanium dioxide demethylates USP42. 1 / 1
1 |
ctd
No evidence text available
35295148
Thioacetamide affects USP42
1 |
Thioacetamide increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
34492290
Temozolomide affects USP42
1 |
Temozolomide increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
31758290
Sodium arsenite affects USP42
1 |
Sodium arsenite decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
21297353
Rep affects USP42
1 |
Rep binds USP42. 1 / 1
1 |
biogrid
No evidence text available
| DOI
Pirinixic acid affects USP42
1 |
Pirinixic acid decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
21318169
Phorbol 13-acetate 12-myristate increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
25613284
Perfluorooctane-1-sulfonic acid decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
36331819
Pentachlorophenol affects USP42
1 |
Pentachlorophenol increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
23892564
Paracetamol affects USP42
1 |
Paracetamol decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
21420995
Nitrofen affects USP42
1 |
Nitrofen decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
33484710
MiR-590-3p affects USP42
| 1
MiR-590-3p inhibits USP42. 1 / 1
| 1
reach
"However, the miR-590-3p was downregulated during JEV infection, resulting in the upregulation of USP42 [51]."
36675197
MiR-590 affects USP42
| 1
MiR-590 binds USP42. 1 / 1
| 1
reach
"DENV propagation, MiRNA overexpression, miRNA knockdown, transfection, RT-PCR, luciferase assay, and western blotting have been used in this study to establish the interaction of miR-590 and USP42."
32123831
Methyl methanesulfonate increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
26011545
Let-7b affects USP42
| 1
Let-7b activates USP42. 1 / 1
| 1
reach
"Specifically, let-7b is predicted to target USP44, USP42 and ATXN7L3 [XREF_FIG]."
28604753
Lead diacetate affects USP42
1 |
Lead diacetate increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
20542052
Ionomycin affects USP42
1 |
Ionomycin increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
25613284
Indometacin affects USP42
1 |
Indometacin decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
28628672
Homologous recombination inhibits USP42. 1 / 1
| 1
reach
"HR efficiency that was reduced by knocking down endogenous USP42 was not significantly reverted by transient over-expression of mCherry-fused DHX9, although a trend was seen in that HR efficiency was increased."
32541651
Formaldehyde affects USP42
1 |
Formaldehyde decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
20655997
Foci affects USP42
| 1
USP42 binds foci. 1 / 1
| 1
sparser
"From a recent study by Liu et al. they reported in different cell lines endogenous USP42 (Ubiquitin carboxyl-terminal hydrolase 42) can form nuclear foci through its C -terminal IDR regions present ou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38723938
Experimental process activates USP42. 1 / 1
| 1
eidos
"We also established through various in vitro and in vivo experiments that increased USP42 can maintain a higher cellular level of both TRIM21 as well as OAS1 ."
35779335
Doxorubicin affects USP42
1 |
Doxorubicin decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
29803840
Dorsomorphin affects USP42
1 |
Dorsomorphin decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
27188386
Disulfiram affects USP42
1 |
Disulfiram decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
20530235
Different methodologies affects USP42
| 1
Different methodologies inhibits USP42. 1 / 1
| 1
eidos
"USP42 depletion hinders cell proliferation and alters nuclear speckle morphology After comparing different methodologies to deplete USP42 expression , we achieved the best efficiency using CRISPR / Cas9 although without complete knockout , instead obtaining reduction to ~ 50 % , likely due to one allele disruption ( Fig. 6A ) ."
33731873
Dexamethasone affects USP42
1 |
Dexamethasone decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
28628672
Deltamethrin affects USP42
1 |
Deltamethrin increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
37019170
Coumarin affects USP42
1 |
Coumarin dephosphorylates USP42. 1 / 1
1 |
ctd
No evidence text available
35688186
Copper(II) sulfate increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
19549813
Cisplatin affects USP42
1 |
Cisplatin decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
27594783
Chlorpyrifos affects USP42
1 |
Chlorpyrifos decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
37019170
Caffeine affects USP42
1 |
Caffeine dephosphorylates USP42. 1 / 1
1 |
ctd
No evidence text available
35688186
Beta-D-glucose affects USP42
1 |
Beta-D-glucose decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
36331819
Benzo[a]pyrene affects USP42
1 |
Benzo[a]pyrene methylates USP42. 1 / 1
1 |
ctd
No evidence text available
27901495
Aristolochic acid A decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
33212167
Amitrole affects USP42
1 |
Amitrole decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
38685447
ZEB1 affects USP42
1 |
USP42 binds ZEB1. 1 / 1
1 |
biogrid
No evidence text available
29119051
ZCCHC10 affects USP42
1 |
ZCCHC10 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
YWHAQ affects USP42
1 |
YWHAQ binds USP42. 1 / 1
1 |
biogrid
No evidence text available
20618440
YTHDC2 affects USP42
1 |
USP42 binds YTHDC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
YAP1 affects USP42
| 1
USP42 binds YAP1 and EGFR. 1 / 1
| 1
sparser
"EGFR fusions are rare genomic events in NSCLC, and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3 and EGFR-ZCCHC6."
34342091
Water Pollutants, Chemical decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
20526952
WDR18 affects USP42
1 |
USP42 binds WDR18. 1 / 1
1 |
biogrid
No evidence text available
19615732
VIRMA affects USP42
1 |
VIRMA binds USP42. 1 / 1
1 |
biogrid
No evidence text available
29507755
USP7 affects USP4
| 1
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP42 inhibits viral RNA genome replication. 1 / 1
| 1
reach
"Our results explain both scenarios that how an elevated TRIM21 (via USP42 mediated stabilization) can suppress viral replication (via OAS1) and simultaneously initiates a cascades of neuroinflammatory[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35779335
USP42 affects ubiquitination clearance
| 1
USP42 inhibits ubiquitination clearance. 1 / 1
| 1
eidos
"We found that USP42 blocks ubiquitination and clearance of ZNRF3 / RNF43 by R-spondin ."
33786993
USP42 affects ubiquitination ZNRF3 RNF43
| 1
USP42 inhibits ubiquitination ZNRF3 RNF43. 1 / 1
| 1
eidos
"Expression of USP42 reduced the ubiquitination of ZNRF3 and RNF43 at the plasma membrane ( Fig 3A , 2nd IP , lanes 3-4 and lanes 7-8 , respectively ) ."
33786993
USP42 affects turnover Wnt receptors
| 1
USP42 activates turnover Wnt receptors. 1 / 1
| 1
eidos
"Accordingly , USP42 promotes the turnover of the Wnt receptors LRP6 and FZD and inhibits Wnt / beta-catenin signalling ."
33786993
USP42 affects turnover LRP6 Frizzled FZD
| 1
USP42 activates turnover LRP6 Frizzled FZD. 1 / 1
| 1
eidos
"Accordingly , USP42 increases the turnover of LRP6 and Frizzled ( FZD ) receptors and inhibits Wnt signalling ."
33786993
USP42 affects this family
| 1
USP42 activates this family. 1 / 1
| 1
reach
"siRNA 2 treatment resulted in p27 downregulation between 24 h and 48 h of treatment, and siRNA 7 treatment resulted in the upregulation of p27 at the 72 h timepoint.Our results, along with the available information in the literature, leads us to hypothesize that the USP42 p.(Gly486Arg) missense mutation is the underlying cause of NSFNMTC in this family."
38338801
USP42 affects survival HCT116 cells
| 1
USP42 inhibits survival HCT116 cells. 1 / 1
| 1
eidos
"Loss of USP42 promotes Wnt-dependent EMT , survival and proliferation in HCT116 cells A-C D , E F , G Spheroid formation experiments with HCT116 cells upon transfection with siUSP42 ."
33786993
USP42 affects stabilize TRIM21 OAS1 neuroinflammatory anti-viral response human microglia
| 1
USP42 activates stabilize TRIM21 OAS1 neuroinflammatory anti-viral response human microglia. 1 / 1
| 1
eidos
"Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia ."
35779335
USP42 affects spheroid growth
| 1
USP42 activates spheroid growth. 1 / 1
| 1
eidos
"As in the case of HCT116 cells , knockdown of USP42 in RKO promoted spheroid growth and colony formation , which was blocked by PORCN inhibitors ( Fig EV5A-C ) ."
33786993
USP42 affects rich domain
| 1
Mutated USP42 activates rich domain. 1 / 1
| 1
reach
"Expression of USP42 mutants targeting the linker domain and the C-terminal lysine rich domain (XREF_FIG B) showed that although the DUB-inactive USP42 C120A mutant retained the ability to bind histone H2B, this interaction was reduced with the DeltaKK mutant and lost with the Deltalinker mutant (XREF_FIG C)."
25336640
USP42 affects repair
| 1
USP42 activates repair. 1 / 1
| 1
eidos
"This fact has also been demonstrated by others , since , it has been recently shown , that USP42 and DHX9 promote DSB repair , through R-loop resolution and have a role in DNA resection , as well ( Matsui et al ., 2020 ) ."
34691154
USP42 affects rep
1 |
Rep binds USP42. 1 / 1
1 |
biogrid
No evidence text available
| DOI
USP42 affects poly-ubiquitination Fig 1I
| 1
USP42 inhibits poly-ubiquitination Fig 1I. 1 / 1
| 1
eidos
"We immunoprecipitated ZNRF3 under denaturing conditions and found that knockdown of USP42 increased its poly-ubiquitination ( Fig 1I ) ."
33786993
USP42 affects pathway
| 1
USP42 activates pathway. 1 / 1
| 1
sparser
"These observations suggested that USP42 silencing activates the JNK/p38 pathway, ultimately accelerating apoptosis in breast cancer cells."
41120683
USP42 affects p53-dependent genotoxic response
| 1
USP42 activates p53-dependent genotoxic response. 1 / 1
| 1
eidos
"USP42 also promotes p53-dependent genotoxic response ( Hock et al , 2011 ) ( Fig EV2 ) ."
33786993
USP42 affects oligoadenylate synthetase 1
| 1
USP42 leads to the deubiquitination of oligoadenylate synthetase 1. 1 / 1
| 1
reach
"USP42 enhances the deubiquitination and stabilization of oligoadenylate synthetase 1 (OAS1) and TRIM21, leading to neuroinflammation and antiviral responses [51]."
36675197
USP42 affects nuclear speckles marked SC35
| 1
USP42 activates nuclear speckles marked SC35. 1 / 1
| 1
eidos
"Interestingly , a decrease in USP42 expression led to a significantly reduced number of nuclear speckles marked with SC35 ( Fig. 6E ; Supplementary Fig. 5B ) ."
33731873
USP42 affects nuclear speck
| 1
USP42 activates nuclear speck. 1 / 1
| 1
eidos
"Depletion of USP42 leads to a reduced number of nuclear speckles and attenuated cell growth ."
33731873
USP42 affects mouse intestinal organoids
| 1
USP42 inhibits mouse intestinal organoids. 1 / 1
| 1
eidos
"Taken together we concluded that Usp42 inhibits paracrine Wnt signalling in mouse small intestinal organoids ."
33786993
USP42 affects most included intestinal stem cell signature
| 1
USP42 inhibits most included intestinal stem cell signature. 1 / 1
| 1
eidos
"Notably , knockdown of USP42 upregulated most of the 45 genes included in the intestinal stem cell proliferation signature ( Merlos-Suarez et al , 2011 ) ( Fig 5B and Dataset EV1F ) ."
33786993
USP42 affects morphological HCT116 cells including shift cobblestone-like elongated cell-cell contact
| 1
USP42 activates morphological HCT116 cells including shift cobblestone-like elongated cell-cell contact. 1 / 1
| 1
eidos
"In agreement with our RNA-sequencing results ( Fig 5C ) , knockdown of USP42 induced morphological changes in HCT116 cells , including a shift from cobblestone-like to elongated phenotype and loss of cell-cell contact ( Fig 5D ) , which are characteristics of EMT ( Thiery & Sleeman , 2006 ; Roger et al , 2010 ; Nieto et al , 2016 ) ."
33786993
USP42 affects miR-590
| 1
MiR-590 binds USP42. 1 / 1
| 1
reach
"DENV propagation, MiRNA overexpression, miRNA knockdown, transfection, RT-PCR, luciferase assay, and western blotting have been used in this study to establish the interaction of miR-590 and USP42."
32123831
USP42 affects mRNA splicing events
| 1
USP42 activates mRNA splicing events. 1 / 1
| 1
eidos
"Functionally , USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth , which is consistent with the impact of PLRG1 repression ."
33731873
USP42 affects histone H2B .
| 1
USP42 deubiquitinates histone H2B .. 1 / 1
| 1
reach
"USP42 was suggested to enhance transcription by deubiquitylating histone H2B ."
32541651
USP42 affects foci
| 1
USP42 binds foci. 1 / 1
| 1
sparser
"From a recent study by Liu et al. they reported in different cell lines endogenous USP42 (Ubiquitin carboxyl-terminal hydrolase 42) can form nuclear foci through its C -terminal IDR regions present ou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38723938
USP42 affects estrone
| 1
USP42 increases the amount of estrone. 1 / 1
| 1
reach
"USP42 knockdown significantly reduced the expression of Cyclin D1, Cyclin E1 and PCNA (XREF_FIG)."
27030989
USP42 affects epithelial
| 1
USP42 activates epithelial. 1 / 1
| 1
eidos
"In addition , knockdown of USP42 downregulated epithelial genes and upregulated mesenchymal genes from the EMT gene signature in cancer ( N = 171 genes ) ( Rokavec et al , 2017 ) ( Fig 5C and Dataset EV1G ) ."
33786993
USP42 affects endogenous LRP6 protein
| 1
USP42 inhibits endogenous LRP6 protein. 1 / 1
| 1
eidos
"Finally , knockdown of USP42 in HEK293T increased endogenous LRP6 protein levels , both in basal conditions and upon RSPO3 treatment ( Fig 3H ) ."
33786993
USP42 affects doxycycline
| 1
USP42 decreases the amount of doxycycline. 1 / 1
| 1
reach
"Interestingly, depletion of USP42 also slightly reduced the basal expression of doxycycline driven GFP and substantially decreased the induced levels of GFP expression following doxycycline treatment of the cells (XREF_FIG, C and D)."
25336640
USP42 affects deterred cancer cell growth
| 1
USP42 inhibits deterred cancer cell growth. 1 / 1
| 1
eidos
"Functionally , USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth , which is consistent with the impact of PLRG1 repression ."
33731873
USP42 affects colorectal cancer cells B C D E
| 1
USP42 inhibits colorectal cancer cells B C D E. 1 / 1
| 1
eidos
"USP42 inhibits paracrine Wnt signalling in colorectal cancer cells A B C D E , F qPCR analysis of USP42 , LGR5 and AXIN2 expression levels in HCT116 cells ."
33786993
USP42 affects colony
| 1
USP42 activates colony. 1 / 1
| 1
eidos
"As in the case of HCT116 cells , knockdown of USP42 in RKO promoted spheroid growth and colony formation , which was blocked by PORCN inhibitors ( Fig EV5A-C ) ."
33786993
USP42 affects colony HCT116 cells
| 1
USP42 inhibits colony HCT116 cells. 1 / 1
| 1
eidos
"Conversely , knockdown of USP42 increased colony formation in HCT116 cells ( Fig EV4D and E ) ."
33786993
USP42 affects cell
| 1
USP42 inhibits cell. 1 / 1
| 1
eidos
"To investigate whether USP42 inhibits Wnt-driven cell proliferation , we performed spheroid assays , which are more representative for the in vivo growth conditions than 2D cultures , as they recapitulate tumour cell clusters ( Timmins et al , 2004 ) ."
33786993
USP42 inhibits cell differentiation. 1 / 1
| 1
reach
"Knockdown of USP42 can significantly promote the osteogenic differentiation of hASCs in vitro and in vivo , and overexpression of USP42 significantly inhibits in vivo osteogenic differentiation of hASCs, and USP42 can provide a potential therapeutic target for bone tissue engineering."
38318890
USP42 affects biological role
| 1
eidos
"Given the wide range of functions of ZNRF3 / RNF43 in embryogenesis ( Chang et al , 2020 ; Lee et al , 2020 ) , limb development ( Szenker-Ravi et al , 2018 ) , liver zonation ( Planas-Paz et al , 2016 ) , intestinal tract and adrenal gland homeostasis ( Koo et al , 2012 ; Basham et al , 2019 ) and sex determination ( Harris et al , 2018 ) , it would be important to explore whether USP42 also contributes to these biological functions ."
33786993
USP42 affects basic induced transcription many promoters
| 1
USP42 activates basic induced transcription many promoters. 1 / 1
| 1
eidos
"The decrease in USP42 expression regulates the ubiquitination of H2B and inhibits the basic and induced transcription of many promoters ( Hock et al ., 2014 ) ."
34456895
USP42 affects alternative splicing cancer-related
| 1
USP42 activates alternative splicing cancer-related. 1 / 1
| 1
eidos
"USP42 modulates alternative splicing of cancer-related genes through regulating PLRG1 ."
33731873
USP42 affects ZNRF3 RNF43 residence
| 1
USP42 activates ZNRF3 RNF43 residence. 1 / 1
| 1
eidos
"Accordingly , USP42 strongly increased ZNRF3 and RNF43 residence at the plasma membrane ( Fig 3A , 1st IP , lanes 3-4 and lanes 7-8 , respectively ) ."
33786993
USP42 affects ZEB1
1 |
USP42 binds ZEB1. 1 / 1
1 |
biogrid
No evidence text available
29119051
USP42 affects ZCCHC10
1 |
ZCCHC10 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP42 affects YWHAQ
1 |
YWHAQ binds USP42. 1 / 1
1 |
biogrid
No evidence text available
20618440
USP42 affects YTHDC2
1 |
USP42 binds YTHDC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects YAP1
| 1
USP42 binds YAP1 and EGFR. 1 / 1
| 1
sparser
"EGFR fusions are rare genomic events in NSCLC, and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3 and EGFR-ZCCHC6."
34342091
USP42 affects Wnt-dependent
| 1
USP42 inhibits Wnt-dependent. 1 / 1
| 1
eidos
"Loss of USP42 leads to Wnt-dependent proliferation and EMT A B , C D E , H I-L Spheroid formation experiments with HCT116 cells upon transfection with siUSP42 ( I-K ) or electroporation with eSpCas9 empty plasmid ( non-edited ) or eSpCas9-USP42 gRNAs ( L ) ."
33786993
USP42 affects Wnt signalling Abstract tumour
| 1
USP42 inhibits Wnt signalling Abstract tumour. 1 / 1
| 1
eidos
"USP42 protects ZNRF3 / RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling Nicole Giebel et al Abstract The tumour suppressors RNF43 and ZNRF3 play a central role in development and tissue homeostasis by promoting the turnover of the Wnt receptors LRP6 and Frizzled ( FZD ) ."
33786993
USP42 affects Wnt reporter
| 1
USP42 inhibits Wnt reporter. 1 / 1
| 1
eidos
"Critically , knockdown of USP42 did not upregulate Wnt reporter activity in ZNRF3 / RNF43 double knockout HEK293T cells ( Fig 1F ) , indicating a requirement of the E3 ligases for USP42 activity in Wnt signalling ."
33786993
USP42 affects Wnt functions including stabilisation proteins
| 1
USP42 activates Wnt functions including stabilisation proteins. 1 / 1
| 1
eidos
"As such , it would be interesting to explore whether USP42 also contributes to other Wnt functions including stabilisation of proteins ( Wnt / STOP ) ( Taelman et al , 2010 ; Acebron et al , 2014 ) , activation of macropinocytosis ( Tejeda-Munoz et al , 2019 ) and modulation of Wnt / Jun and Wnt / Ca +2 ( Tsukiyama et al , 2015 ) ."
33786993
USP42 affects Wnt beta-catenin signalling
| 1
USP42 inhibits Wnt beta-catenin signalling. 1 / 1
| 1
eidos
"Accordingly , USP42 promotes the turnover of the Wnt receptors LRP6 and FZD and inhibits Wnt / beta-catenin signalling ."
33786993
USP42 affects Wnt beta-catenin signalling A B C D E-H
| 1
USP42 inhibits Wnt beta-catenin signalling A B C D E-H. 1 / 1
| 1
eidos
"USP42 deubiquitinates ZNRF3 and inhibits Wnt / beta-catenin signalling A B C D E-H I , J K L , M TOPflash reporter assays in HEK293T cells stimulated with either control , Wnt3a , Wnt3a and RSPO1-4 conditioned media , or by transfection with the indicated constructs ."
33786993
USP42 affects WDR18
1 |
USP42 binds WDR18. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects VIRMA
1 |
VIRMA binds USP42. 1 / 1
1 |
biogrid
No evidence text available
29507755
USP42 affects Ubiquitin
| 1
USP42 inhibits Ubiquitin. 1 / 1
| 1
reach
"69 Another DUB, USP42, prevents the ubiquitin‐mediated turnover of RNF43 and ZNRF3 to promote Wnt receptor degradation."
39520379
USP42 affects USP4
| 1
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP42 affects USP36
| 1
USP36 binds USP42. 1 / 1
| 1
sparser
"This suggests the possibility that after the et duplication event that formed both USP36 and USP42; USP36 evolved and took over the function of the long Et protein, whereas USP42 evolved and took over[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19217892
USP42 affects UBC
1 |
UBC binds USP42. 1 / 1
1 |
biogrid
No evidence text available
29576527
USP42 affects TWIST1
| 1
USP42 decreases the amount of TWIST1. 1 / 1
| 1
reach
"Transfection of USP42 siRNA significantly reduced the expression levels of beta-catenin, Twist and Snail1, while increasing E-cadherin."
27030989
USP42 affects TP53BP1
| 1
USP42 inhibits TP53BP1. 1 / 1
| 1
reach
"Of note, loss of other R-loop resolution factors, such as DDX1 or EXOSC10, augmented NHEJ efficiency at the cost of HR efficiency, and loss of USP42/DHX9 increased 53BP1 foci (Domingo-Prim et al., 2019; Li et al., 2016; Matsui et al., 2020)."
35508167
USP42 affects TIPARP
1 |
TIPARP binds USP42. 1 / 1
1 |
biogrid
No evidence text available
35439318
USP42 affects TEX10
1 |
USP42 binds TEX10. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects Snail1
| 1
USP42 decreases the amount of Snail1. 1 / 1
| 1
reach
"Transfection of USP42 siRNA significantly reduced the expression levels of beta-catenin, Twist and Snail1, while increasing E-cadherin."
27030989
USP42 affects SUZ12
1 |
SUZ12 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
27634302
USP42 affects SRSF4
1 |
SRSF4 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP42 affects SRRM2
1 |
USP42 binds SRRM2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects SPP1
1 |
SPP1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
22779921
USP42 affects SNRNP40
1 |
SNRNP40 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
37689310
USP42 affects RPS6KA2
1 |
RPS6KA2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
40437099
USP42 affects RPS3
1 |
RPS3 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP42 affects RPL11
1 |
RPL11 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP42 affects RPA2
| 1
USP42 leads to the phosphorylation of RPA2. 1 / 1
| 1
reach
"Although exogenously expressed GFP-USP42 (FL) restored CPT-induced phosphorylation of RPA2, cells expressing truncated mutants of USP42 that lost nuclear speckle localization failed to rescue this phenotype, suggesting that nuclear speckle localization of USP42 is indispensable for proper HR progression."
32541651
USP42 affects RNPS1
1 |
RNPS1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP42 affects RNF4
1 |
RNF4 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
29180619
USP42 affects RNF10
1 |
RNF10 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
37723588
USP42 affects RNA Pol II
| 1
USP42 binds RNA Pol II. 1 / 1
| 1
reach
"Immunofluorescence analysis of endogenous proteins showed that USP42 was present in nuclear foci that co-localized with DNA bound RNA Pol II using antibodies to detect both total and activated (phosphorylated) RNA Pol II (XREF_FIG E), and endogenous USP42 and RNA Pol II were shown to co-immunoprecipitate (XREF_FIG F)."
25336640
USP42 affects RKO cells B C D Immunofluorescence microscopy showing endogenous RKO cells
| 1
USP42 inhibits RKO cells B C D Immunofluorescence microscopy showing endogenous RKO cells. 1 / 1
| 1
eidos
"USP42 inhibits paracrine Wnt signalling in RKO cells A B C D Immunofluorescence microscopy showing endogenous E-cadherin levels in RKO cells upon transfection with siUSP42 ."
33786993
USP42 affects RIOX1
1 |
USP42 binds RIOX1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects RELA
1 |
RELA binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33438746
USP42 affects RANBP9
1 |
USP42 binds RANBP9. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects RAD50
1 |
USP42 binds RAD50. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects R Z autoubiquitination
| 1
USP42 inhibits R Z autoubiquitination. 1 / 1
| 1
eidos
"Interestingly , R / Z autoubiquitination is also a dynamic process and is reversed by Usp42 , a deubiquitinase that stabilizes R / Z levels at the plasma membrane , counteracting Rspo / Lgr4-mediated clearance and promoting Wnt inhibition125 ,126 ."
36117218
USP42 affects Ppp6c
1 |
Ppp6c binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP42 affects PROGNOSIS
| 1
USP42 binds PROGNOSIS. 1 / 1
| 1
trips
"circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis."
32938310
USP42 affects PRNP
1 |
PRNP binds USP42. 1 / 1
1 |
biogrid
No evidence text available
36543142
USP42 affects PRKRA
1 |
PRKRA binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP42 affects POU5F1
1 |
POU5F1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP42 affects POLD1
1 |
POLD1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
37105989
USP42 affects PCGF1
1 |
PCGF1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP42 affects OAS1
| 1
USP42 decreases the amount of OAS1. 1 / 1
| 1
reach
"We hypothesize that USP42 being a deubiquitinase can reduce the ubiquitinated levels of OAS1 and thereby stabilize the cellular OAS1 levels."
35779335
USP42 affects Neoplasms
| 1
USP42 activates Neoplasms. 1 / 1
| 1
eidos
"USP42 was reported to stabilize TP53 , but USP42 knockdown inhibits cancer formation , implying that other unknown factors related to cancer formation may exist [ 53 ] ."
31133011
reach
"Thus, our data indicated that elevated expression of USP42 in GC may promote tumor metastasis and is associated with the clinical outcome of GC patients."
27030989
USP42 affects NR2C2
1 |
NR2C2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
30463901
USP42 affects NFKBIL1
1 |
NFKBIL1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP42 affects NANOG
1 |
NANOG binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP42 affects Mad2l2
1 |
Mad2l2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP42 affects MYH9
1 |
MYH9 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
40437099
USP42 affects MYC
1 |
MYC binds USP42. 1 / 1
1 |
biogrid
No evidence text available
36424410
USP42 affects MRPS35
1 |
USP42 binds MRPS35. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects MRPS34
1 |
USP42 binds MRPS34. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects MRPS31
1 |
USP42 binds MRPS31. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects MRPS26
1 |
USP42 binds MRPS26. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects MRPS21
1 |
USP42 binds MRPS21. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects MRPS14
1 |
USP42 binds MRPS14. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects MMP2
| 1
USP42 increases the amount of MMP2. 1 / 1
| 1
reach
"As shown in XREF_FIG, silencing of USP42 downregulated the expression of MMP-2 and MMP-9."
27030989
USP42 affects MECP2
1 |
MECP2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
38697112
USP42 affects MDM2
1 |
USP42 binds MDM2. 1 / 1
1 |
biogrid
No evidence text available
22085928
USP42 affects MAGEB2
1 |
MAGEB2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP42 affects LRRC47
1 |
USP42 binds LRRC47. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects LRP6 receptors
| 1
USP42 leads to the ubiquitination of LRP6 receptors. 1 / 1
| 1
reach
"In this way USP42 antagonizes RSPOs by protecting ZNRF3/RNF43 from RSPO- and ubiquitin-dependent internalization, thereby increasing the ubiquitylation and turnover of FZD and LRP6 receptors, and inhibiting WNT signaling."
35817504
USP42 affects KPNA3
1 |
USP42 binds KPNA3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects HRAS
1 |
HRAS binds USP42. 1 / 1
1 |
biogrid
No evidence text available
30655611
USP42 affects HMGB1
1 |
HMGB1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
41161382
USP42 affects HERC2
1 |
USP42 binds HERC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects HCT116 cells A-C D
| 1
USP42 inhibits HCT116 cells A-C D. 1 / 1
| 1
eidos
"Loss of USP42 promotes Wnt-dependent EMT , survival and proliferation in HCT116 cells A-C D , E F , G Spheroid formation experiments with HCT116 cells upon transfection with siUSP42 ."
33786993
USP42 affects HCT116 Cells
| 1
USP42 inhibits HCT116 Cells. 1 / 1
| 1
eidos
"We conclude that USP42 inhibits Wnt signalling in HCT116 cells by destabilising the Wnt receptors , independently of its roles in p53 response to genotoxic stress ."
33786993
USP42 affects H4C16
1 |
H4C16 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
30804502
USP42 affects H2BC21
1 |
USP42 binds H2BC21. 1 / 1
1 |
biogrid
No evidence text available
25336640
USP42 affects H2BC10
1 |
USP42 deubiquitinates H2BC10. 1 / 1
1 |
ubibrowser
"Depletion of <span class="match term0">USP42</span> increased <span class="match term1">H2B</span> ubiquitylation at a model promoter and decreased both basal and induced transcription from a number of promoters"
25336640
USP42 affects G0/G1 block
| 1
USP42 activates G0/G1 block. 1 / 1
| 1
reach
"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size, TNM staging, lymph node metastasis, and OS rate of GC patients, while inhibition of USP42 can induce G0/G1 block and suppress cell proliferation and invasion."
33791299
USP42 affects G0 G1
| 1
USP42 activates G0 G1. 1 / 1
| 1
eidos
"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size , TNM staging , lymph node metastasis , and OS rate of GC patients , while inhibition of USP42 can induce G0 / G1 block and suppress cell proliferation and invasion ( Hou et al ., 2016 ) ."
33791299
USP42 affects Flag
| 1
USP42 binds Flag. 1 / 1
| 1
sparser
"We also overexpressed the USP42 gene by exogenous Flag-USP42 plasmid transfection."
35779335
USP42 affects FlaG
| 1
USP42 binds FlaG. 1 / 1
| 1
sparser
"FLAG–USP42 plasmids were a kind gift from Karen H Vousden, The Beatson Institute for Cancer Research, Glasgow, UK ( Hock et al., 2011 )."
35779335
USP42 affects FECH
1 |
USP42 binds FECH. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects EZH2
1 |
EZH2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
27634302
USP42 affects EMT A B
| 1
USP42 inhibits EMT A B. 1 / 1
| 1
eidos
"Loss of USP42 leads to Wnt-dependent proliferation and EMT A B , C D E , H I-L Spheroid formation experiments with HCT116 cells upon transfection with siUSP42 ( I-K ) or electroporation with eSpCas9 empty plasmid ( non-edited ) or eSpCas9-USP42 gRNAs ( L ) ."
33786993
USP42 affects DPPA4
1 |
DPPA4 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP42 affects DIMT1
1 |
USP42 binds DIMT1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects Cyclin
| 1
USP42 increases the amount of Cyclin. 1 / 1
| 1
reach
"USP42 knockdown significantly reduced the expression of Cyclin D1, Cyclin E1 and PCNA (XREF_FIG)."
27030989
USP42 affects Cell Survival
| 1
USP42 activates Cell Survival. 1 / 1
| 1
reach
"In vitro and in vivo studies showed that USP42 knockdown inhibited GC cell survival and invasion, suggesting that USP42 may be a therapeutic target [62]."
36497313
USP42 affects CTNNB1
| 1
USP42 decreases the amount of CTNNB1. 1 / 1
| 1
reach
"Transfection of USP42 siRNA significantly reduced the expression levels of beta-catenin, Twist and Snail1, while increasing E-cadherin."
27030989
USP42 affects CPNE3
1 |
USP42 binds CPNE3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects CPEB2
1 |
CPEB2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
34133714
USP42 affects CEP250
1 |
CEP250 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
40437099
USP42 affects CEP192
1 |
CEP192 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
24613305
USP42 affects CDH1
| 1
USP42 decreases the amount of CDH1. 1 / 1
| 1
reach
"In gastric cancer cells, USP42 is regarded as an invasion promotor since the evidence showed that silencing of USP42 upregulated the expression of the E-cadherin, and downregulated the expression of MMPs, beta-catenin, Twist, and Snail1."
28279784
USP42 affects CA2
1 |
USP42 binds CA2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects BRCA1
| 1
USP42 activates BRCA1. 1 / 1
| 1
reach
"Based on these results, we propose a model in which USP42 and DHX9 promote BRCA1 loading to DSB sites near nuclear speckles, which facilitates DSB-induced R-loop resolution and preferential DSB repair by HR."
32541651
USP42 affects BMS1
1 |
USP42 binds BMS1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects BCOR
1 |
BCOR binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP42 affects AVPR2
| 1
USP42 binds AVPR2. 1 / 1
| 1
sparser
"We conclude that cytoplasmic and catalytically active USP42 interacts with the ZNRF3 DIR (Fig  xref ), which is emerging as a key modulatory domain of the E3 ligase (Jiang et al, xref ; Chang et al, xref ; Spit et al, xref ; Tsukiyama et al, xref )."
33786993
USP42 affects AURKA
1 |
USP42 binds AURKA. 1 / 1
1 |
biogrid
No evidence text available
33669244
USP42 affects ANK2
1 |
ANK2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
36950384
USP42 affects AMOT
1 |
USP42 binds AMOT. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP42 affects ALK
1 |
ALK binds USP42. 1 / 1
1 |
biogrid
No evidence text available
34273398
USP4 affects USP7
| 1
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
USP36 affects USP42
| 1
USP36 binds USP42. 1 / 1
| 1
sparser
"This suggests the possibility that after the et duplication event that formed both USP36 and USP42; USP36 evolved and took over the function of the long Et protein, whereas USP42 evolved and took over[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19217892
USP10 affects USP4
| 1
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
UBC affects USP42
1 |
UBC binds USP42. 1 / 1
1 |
biogrid
No evidence text available
29576527
TRIM21 RING domain affects USP42
| 1
TRIM21 RING domain activates USP42. 1 / 1
| 1
eidos
"This study also suggests that TRIM21 , independently of its RING domain , can increase USP42 level in a positive feedback loop and induces the cellular OAS1 levels in human microglial cells ."
35779335
TP53 affects USP4
| 1
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
TP53 affects USP10, USP42, and USP7
| 1
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
TP53 affects USP10, USP4, USP42, and USP7
| 1
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
TIPARP affects USP42
1 |
TIPARP binds USP42. 1 / 1
1 |
biogrid
No evidence text available
35439318
TEX10 affects USP42
1 |
USP42 binds TEX10. 1 / 1
1 |
biogrid
No evidence text available
19615732
Stomach Neoplasms affects USP42
| 1
USP42 binds Stomach Neoplasms. 1 / 1
| 1
sparser
"Further clinical characteristics analysis showed that expression level of USP42 was associated with overall survival of GC patients."
27030989
SUZ12 affects USP42
1 |
SUZ12 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
27634302
SRSF4 affects USP42
1 |
SRSF4 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
SRRM2 affects USP42
1 |
USP42 binds SRRM2. 1 / 1
1 |
biogrid
No evidence text available
19615732
SPP1 affects USP42
1 |
SPP1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
22779921
SNRNP40 affects USP42
1 |
SNRNP40 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
37689310
RPS6KA2 affects USP42
1 |
RPS6KA2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
40437099
RPS3 affects USP42
1 |
RPS3 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
RPL11 affects USP42
1 |
RPL11 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
RNPS1 affects USP42
1 |
RNPS1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
RNF4 affects USP42
1 |
RNF4 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
29180619
RNF10 affects USP42
1 |
RNF10 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
37723588
RNA Pol II affects USP42
| 1
USP42 binds RNA Pol II. 1 / 1
| 1
reach
"Immunofluorescence analysis of endogenous proteins showed that USP42 was present in nuclear foci that co-localized with DNA bound RNA Pol II using antibodies to detect both total and activated (phosphorylated) RNA Pol II (XREF_FIG E), and endogenous USP42 and RNA Pol II were shown to co-immunoprecipitate (XREF_FIG F)."
25336640
RIOX1 affects USP42
1 |
USP42 binds RIOX1. 1 / 1
1 |
biogrid
No evidence text available
19615732
RELA affects USP42
1 |
RELA binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33438746
RANBP9 affects USP42
1 |
USP42 binds RANBP9. 1 / 1
1 |
biogrid
No evidence text available
19615732
RAD50 affects USP42
1 |
USP42 binds RAD50. 1 / 1
1 |
biogrid
No evidence text available
19615732
Ppp6c affects USP42
1 |
Ppp6c binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26496610
PROGNOSIS affects USP42
| 1
USP42 binds PROGNOSIS. 1 / 1
| 1
trips
"circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis."
32938310
PRNP affects USP42
1 |
PRNP binds USP42. 1 / 1
1 |
biogrid
No evidence text available
36543142
PRKRA affects USP42
1 |
PRKRA binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
POU5F1 affects USP42
1 |
POU5F1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
POLD1 affects USP42
1 |
POLD1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
37105989
PLRG1 affects USP42
1 |
USP42 binds PLRG1. 1 / 1
1 |
biogrid
No evidence text available
19615732
PCGF1 affects USP42
1 |
PCGF1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
Organic Chemicals affects USP42
1 |
Organic Chemicals decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
20526952
NUP214 affects USP42
| 1
NUP214 increases the amount of USP42. 1 / 1
| 1
reach
"These findings establish that DENV-NS5 protein can potentially modulate the host deubiquitinase protein USP42 expression via altering cellular miR-590 levels in human microglial cells."
32123831
NS5 affects USP42
| 1
NS5 inhibits USP42. 1 / 1
| 1
reach
"One of the recent findings reported that dengue NS5 mediated alternation in miR-590 suppresses a de-ubiquitinase protein USP42 that results in increased viral replication [ 72 ]."
34968791
NR2C2 affects USP42
1 |
NR2C2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
30463901
NFKBIL1 affects USP42
1 |
NFKBIL1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
NANOG affects USP42
1 |
NANOG binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
Microglia affects USP42
| 1
Microglia inhibits USP42. 1 / 1
| 1
eidos
"34 In this study , we have demonstrated , how DENV NS5 protein alters the host cellular microRNA , miR-590-3p , in microglial cells which in turn downregulate USP42 ( a deubiquitinase ) ."
32123831
Mad2l2 affects USP42
1 |
Mad2l2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26496610
MYH9 affects USP42
1 |
MYH9 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
40437099
MYC affects USP42
1 |
MYC binds USP42. 1 / 1
1 |
biogrid
No evidence text available
36424410
MRPS35 affects USP42
1 |
USP42 binds MRPS35. 1 / 1
1 |
biogrid
No evidence text available
19615732
MRPS34 affects USP42
1 |
USP42 binds MRPS34. 1 / 1
1 |
biogrid
No evidence text available
19615732
MRPS31 affects USP42
1 |
USP42 binds MRPS31. 1 / 1
1 |
biogrid
No evidence text available
19615732
MRPS26 affects USP42
1 |
USP42 binds MRPS26. 1 / 1
1 |
biogrid
No evidence text available
19615732
MRPS21 affects USP42
1 |
USP42 binds MRPS21. 1 / 1
1 |
biogrid
No evidence text available
19615732
MRPS14 affects USP42
1 |
USP42 binds MRPS14. 1 / 1
1 |
biogrid
No evidence text available
19615732
MIR320A affects USP42
1 |
MIR320A decreases the amount of USP42. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
MECP2 affects USP42
1 |
MECP2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
38697112
MDM2 affects USP42
1 |
USP42 binds MDM2. 1 / 1
1 |
biogrid
No evidence text available
22085928
MAGEB2 affects USP42
1 |
MAGEB2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
33961781
LRRC47 affects USP42
1 |
USP42 binds LRRC47. 1 / 1
1 |
biogrid
No evidence text available
19615732
KPNA3 affects USP42
1 |
USP42 binds KPNA3. 1 / 1
1 |
biogrid
No evidence text available
19615732
Japanese infection affects USP42
| 1
Japanese infection activates USP42. 1 / 1
| 1
eidos
"Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia ."
35779335
Histone affects USP42
| 1
Histone binds USP42. 1 / 1
| 1
sparser
"A previous proteomic analysis of the DUB interactome described an association of USP42 with histones, but also with a large number of other proteins, including other DUBs ( xref )."
25336640
HRAS affects USP42
1 |
HRAS binds USP42. 1 / 1
1 |
biogrid
No evidence text available
30655611
HMGB1 affects USP42
1 |
HMGB1 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
41161382
HERC2 affects USP42
1 |
USP42 binds HERC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
H4C16 affects USP42
1 |
H4C16 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
30804502
H2BC21 affects USP42
1 |
USP42 binds H2BC21. 1 / 1
1 |
biogrid
No evidence text available
25336640
Flag affects USP42
| 1
USP42 binds Flag. 1 / 1
| 1
sparser
"We also overexpressed the USP42 gene by exogenous Flag-USP42 plasmid transfection."
35779335
FlaG affects USP42
| 1
USP42 binds FlaG. 1 / 1
| 1
sparser
"FLAG–USP42 plasmids were a kind gift from Karen H Vousden, The Beatson Institute for Cancer Research, Glasgow, UK ( Hock et al., 2011 )."
35779335
FGF2 affects USP42
| 1
FGF2 increases the amount of USP42. 1 / 1
| 1
reach
"In addition, fibroblast growth factor 2 (FGF2) initiated USP42 expression and enhanced the interaction between USP42 and PPARγ during the liver regeneration process."
40091484
FECH affects USP42
1 |
USP42 binds FECH. 1 / 1
1 |
biogrid
No evidence text available
19615732
EZH2 affects USP42
1 |
EZH2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
27634302
EGFR affects YAP1
| 1
USP42 binds YAP1 and EGFR. 1 / 1
| 1
sparser
"EGFR fusions are rare genomic events in NSCLC, and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3 and EGFR-ZCCHC6."
34342091
Dengue NS5 protein affects USP42
| 1
Dengue NS5 protein inhibits USP42. 1 / 1
| 1
eidos
"Dengue NS5 protein downregulate USP42 expression via increasing miR-590 level ."
32123831
DPPA4 affects USP42
1 |
DPPA4 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
DIMT1 affects USP42
1 |
USP42 binds DIMT1. 1 / 1
1 |
biogrid
No evidence text available
19615732
Cas9-mediated ablation standard CRISPR Cas9 protocol affects USP42
| 1
Cas9-mediated ablation standard CRISPR Cas9 protocol inhibits USP42. 1 / 1
| 1
eidos
"CRISPR / Cas9-mediated gene ablation A standard CRISPR / Cas9 protocol was followed to deplete USP42 in H1299 cells [ 22 ] ."
33731873
CRISPR Cas9-mediated ablation standard CRISPR affects USP42
| 1
CRISPR Cas9-mediated ablation standard CRISPR inhibits USP42. 1 / 1
| 1
eidos
"CRISPR / Cas9-mediated gene ablation A standard CRISPR / Cas9 protocol was followed to deplete USP42 in H1299 cells [ 22 ] ."
33731873
CPNE3 affects USP42
1 |
USP42 binds CPNE3. 1 / 1
1 |
biogrid
No evidence text available
19615732
CPEB2 affects USP42
1 |
CPEB2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
34133714
CEP250 affects USP42
1 |
CEP250 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
40437099
CEP192 affects USP42
1 |
CEP192 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
24613305
CA2 affects USP42
1 |
USP42 binds CA2. 1 / 1
1 |
biogrid
No evidence text available
19615732
BMS1 affects USP42
1 |
USP42 binds BMS1. 1 / 1
1 |
biogrid
No evidence text available
19615732
BCOR affects USP42
1 |
BCOR binds USP42. 1 / 1
1 |
biogrid
No evidence text available
26687479
Acrylamide affects USP42
1 |
Acrylamide decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
28959563
AVPR2 affects USP42
| 1
USP42 binds AVPR2. 1 / 1
| 1
sparser
"We conclude that cytoplasmic and catalytically active USP42 interacts with the ZNRF3 DIR (Fig  xref ), which is emerging as a key modulatory domain of the E3 ligase (Jiang et al, xref ; Chang et al, xref ; Spit et al, xref ; Tsukiyama et al, xref )."
33786993
AURKA affects USP42
1 |
USP42 binds AURKA. 1 / 1
1 |
biogrid
No evidence text available
33669244
ANK2 affects USP42
1 |
ANK2 binds USP42. 1 / 1
1 |
biogrid
No evidence text available
36950384
AMOT affects USP42
1 |
USP42 binds AMOT. 1 / 1
1 |
biogrid
No evidence text available
19615732
ALK affects USP42
1 |
ALK binds USP42. 1 / 1
1 |
biogrid
No evidence text available
34273398
3-isobutyl-1-methyl-7H-xanthine decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
28628672
1,2-dimethylhydrazine increases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
22206623
4,4'-sulfonyldiphenol decreases the amount of USP42. 1 / 1
1 |
ctd
No evidence text available
28628672