IndraLab

Statements

USP37 is modified
5 | 1 23 4
USP37 is phosphorylated.
5 | 13 4
USP37 is phosphorylated. 10 / 14
| 11 3
sparser
"Inactivation of CDK2 in mitosis results in loss of USP37 phosphorylation."
21596315
sparser
"Therefore USP37 phosphorylation correlated with its cell cycle-specific DUB activity."
21596315
sparser
"Subsequent phosphorylation of USP37 by either CDK2/cyclin E or CDK2/cyclin A triggers its full DUB activity."
21596315
rlimsp
"Further, inhibition of CDK2 activity in HBx expressing cells, resulted in a decrease of not only phosphorylated USP37 but also total USP37 protein levels."
25347529
sparser
"Collectively, these data identify CDK2 as the kinase responsible for phosphorylating and activating USP37 during G1/S. We show that USP37 is a DUB that associates with and antagonizes APC CDH1 follow[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
sparser
"Finally, recombinant CDK2/cyclin A phosphorylated wild-type USP37, but neither USP37-S 628 A nor USP37-S 628 D, in an in vitro kinase assay ( Figure 7 H)."
21596315
sparser
"We think that USP37, which is itself an APC CDH1 substrate ( Figure 5 ), is stable during S and G2 for two reasons: (1) phosphorylated USP37 deubiquitinates itself, and (2) CDH1 is phosphorylated by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
rlimsp
"We observed that just as CDC6, the levels of USP37 protein and phosphorylated USP37 decreased in the presence of CDK2 inhibitor ()."
25347529
sparser
"A detailed structural analysis of phosphorylated USP37 may be required to reveal this mechanism."
34177595
rlimsp
"Plk1-mediated phosphorylation of USP37 plays an important role in its recognition by SCF-β-TrCP [7]."
25347529
USP37 is phosphorylated on S650. 3 / 3
3 |
hprd
No evidence text available
18669648
hprd
No evidence text available
19413330
hprd
No evidence text available
17081983
USP37 is phosphorylated on S628. 3 / 3
| 2 1
sparser
"Ser 628 of USP37 was phosphorylated in G1/S, but not mitosis ( Figure 7 E)."
21596315
rlimsp
"A recent study implicates the phosphorylation of Ser-628 of USP37 to protect it from CDH1 mediated ubiquitination [6]."
25347529
sparser
"In G1/S, Ser628 of USP37 is phosphorylated by either CDK2/cyclin E or CDK2/cyclin A, and this triggers USP37 full DUB activity."
32512887
USP37 is phosphorylated on S652. 2 / 2
2 |
hprd
No evidence text available
17081983
hprd
No evidence text available
18669648
USP37 is ubiquitinated.
| 7
USP37 is ubiquitinated. 7 / 7
| 7
sparser
"To assess USP37 ubiquitination, HeLa cell lysates were prepared in NP-40 buffer and denatured by boiling for 10 min after addition of 1% v/v SDS."
21596315
sparser
"The level of USP37 ubiquitination is also reduced by mutations in UIM2 or UIM3, suggesting that they play a role in the ubiquitination of USP37 itself."
| PMC
sparser
"We believe that inappropriate APC CDH1 activity results in USP37 ubiquitination and degradation, which shifts the balance in favor of cyclin A being a substrate rather than an inhibitor of the APC/C.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
sparser
"Furthermore, UIM2 and UIM3, which are located in tandem with an eight–amino acid spacer in the region between the cysteine and histidine boxes, play an essential role in ubiquitin-binding ubiquitination of USP37, and most importantly the full catalytic activity of USP37."
| PMC
sparser
"Ubiquitination of USP37 relied on a KEN box degron located between its C-terminal UIMs ( Figure S4 A)."
21596315
sparser
"The level of USP37 ubiquitination was also reduced by mutations in UIM2 or UIM3, suggesting their role in ubiquitination of USP37 itself."
24324262
sparser
"This regulation is achieved, in part, by association with the E3 ubiquitin ligases APC CDH1 and SCF βTrCP which drives the ubiquitylation and degradation of USP37 [ xref ], although how USP37 degradation regulates mitotic entry remains to be elucidated."
32311336
USP37 is sumoylated.
| 2
USP37 is sumoylated on K452. 2 / 2
| 2
sparser
"Similarly, the increased SUMOylation of USP37 at its catalytic site K452 correlated with an increase in ubiquitylation of its substrate c-Myc at K148 and K389."
28098164
sparser
"We observed an increase in the SUMOylation of USP37 at K452 located in its catalytic domain, a change that was correlated with an increase in the ubiquitylation of c-Myc at K148 and K389."
28098164
USP37 is dephosphorylated.
| 1
USP37 is dephosphorylated. 1 / 1
| 1
sparser
"In late mitosis, CDK2 is no longer active, and thus the APC–CDH1 complex reforms and dephosphorylated USP37 switches from an antagonist to a substrate of the APC-CDH1 complex (Fig. xref )."
| PMC
USP37 is degraded.
| 1
USP37 is degraded. 1 / 1
| 1
trips
"Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry."
23027877
USP37 affects CDH1
| 17 15
USP37 binds CDH1.
| 10 15
CDH1 binds USP37. 10 / 21
| 9 12
sparser
"Knockdown of CDH1 markedly reduced the interaction between USP37 and CDC27 ( Figure 1 F), suggesting that core APC/C components bind USP37 indirectly through CDH1."
21596315
sparser
"We show that the deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A."
21596315
sparser
"They identified interactions between USP37 and CDH1, as well as APC/C subunits, implicating USP37 in the regulation of the G1/S transition and characterized the cell cycle regulation of USP37 ( xref )."
34109183
reach
"We show that the deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A. USP37 was induced by E2F transcription factors in G1, peaked at G1/S, and was degraded in late mitosis."
21596315
sparser
"A direct interaction between USP37 and CDH1 is likely because mixing of USP37 and CDH1 translated individually in rabbit reticulocyte lysates reproduced the interaction observed in cells ( Figure 1 G)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
reach
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
reach
"A direct interaction between USP37 and CDH1 is likely because mixing of USP37 and CDH1 translated individually in rabbit reticulocyte lysates reproduced the interaction observed in cells."
21596315
reach
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
sparser
"USP37 binds to the substrate adaptor CDH1 and removes the polyubiquitin chain, which is the degradation signal, from cyclin A ( xref )."
34177595
sparser
"Usp37 binds APC/C Cdh1 in G1 and deubiquitinates the APC/C substrate cyclin A [ xref ]."
21978762
APC_C binds CDH1 and USP37. 1 / 1
| 1
sparser
"The core components of APC bind with USP37 through CDH1."
| PMC
CDC20 binds CDH1 and USP37. 1 / 1
| 1
sparser
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
CDH1 binds mutated USP37. 1 / 1
| 1
reach
"Consistent with this degron being targeted by APC CDH1, the KEN box-3 mutant USP37 interacted poorly with CDH1 and had a much longer half-life."
21596315
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
USP37 inhibits CDH1.
| 2
USP37 inhibits CDH1. 2 / 2
| 2
reach
"A study by Qin et al. reported that USP37 KD suppresses BC and BC stem cell migration and invasion by promoting the mesenchymal-epithelial transition (MET) by markedly reducing the SNAI1, N-cadherin, and vimentin expression and increasing the E-cadherin."
| PMC
reach
"However, HBx escorts USP37 from the nucleus, downregulates CDH1, and prevents its SCF mediated degradation via increased CDK2-mediated phosphorylation [24]."
| PMC
USP37 increases the amount of CDH1.
| 2
USP37 increases the amount of CDH1. 2 / 2
| 2
reach
"As shown in Fig. 3c and d, knockdown of USP37 significantly decreased Snail1, N-cadherin and Vimentin expression, but increased E-cadherin expression levels."
30482232
reach
"Here, we showed that USP37 siRNA treatment stimulated the expression of epithelial marker (E-cadherin) but decreased the expression of three known inducers of EMT (Snail1, N-cadherin and Vimentin) (Fig. 6a)."
30482232
USP37 decreases the amount of CDH1.
| 2
USP37 decreases the amount of CDH1. 2 / 2
| 2
reach
"As shown in Fig. 3c and d, knockdown of USP37 significantly decreased Snail1, N-cadherin and Vimentin expression, but increased E-cadherin expression levels."
30482232
reach
"Immunofluorescence assay showed that overexpression of USP37 further inhibited E-cadherin expression and upregulated N-cadherin expression (Fig. 3j)."
30482232
USP37 activates CDH1.
| 1
USP37 activates CDH1. 1 / 1
| 1
reach
"Moreover, USP37 contributes to the stabilization of cyclin A by counteracting APC/Cdh1 functioning."
30241373
CDK2 affects USP37
1 2 | 15 11 2
CDK2 phosphorylates USP37.
1 | 8 7 2
CDK2 phosphorylates USP37. 10 / 14
| 7 5 2
reach
"Cyclin A accumulation activates CDK2, which also phosphorylates USP37 to positively reinforce its catalytic activity."
34109183
reach
"We found this interesting because USP37 has been implicated in cell proliferation and transformation [6, 7] as well as in cell-cycle regulation, where during the G1/S transition, CDK2 phosphorylates a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
reach
"Phosphorylation of USP37 by CDK2 stimulated its full activity."
21596315
reach
"Subsequent phosphorylation of USP37 by either CDK2 and cyclin E or CDK2 and cyclin A triggers its full DUB activity."
21596315
reach
"The APC-CDH1 complex does not recognize USP37 as a substrate during S/G2, possibly due to phosphorylation of USP37 by cyclin-dependent kinase 2 (CDK2)/cyclin A. Deubiquitination and phosphorylation of CDH1 by CDKs dissociates CDH1 from the core APC complex during S/G2."
| PMC
sparser
"Cyclin A accumulation activates CDK2, which also phosphorylates USP37 to positively reinforce its catalytic activity."
34109183
sparser
"A mutation in the KEN box degron site affects the stability of USP37 and its ability to deubiquitinate cyclin A. The APC-CDH1 complex does not recognize USP37 as a substrate during S/G2, possibly due to phosphorylation of USP37 by cyclin-dependent kinase 2 (CDK2)/cyclin A. Deubiquitination and phosphorylation of CDH1 by CDKs dissociates CDH1 from the core APC complex during S/G2."
| PMC
rlimsp
"USP37 was inactive in mitosis because it was no longer phosphorylated by CDK2."
21596315
rlimsp
"Phosphorylation of USP37 by CDK2 stimulated its full activity."
21596315
reach
"USP37, which is no longer phosphorylated by CDK2, switches from an antagonist to a substrate of APC CDH1 and is modified with degradative K11 linked polyubiquitin."
21596315
CDK2 phosphorylates USP37 on S628. 3 / 3
1 | 1 1
sparser
"The USP37 activity maximizes when Ser628 of USP37 is phosphorylated by CDK2 ( xref ) ( xref )."
34177595
reach
"In G1/S, Ser628 of USP37 is phosphorylated by either CDK2/cyclin E or CDK2/cyclin A, and this triggers USP37 full DUB activity."
32512887
biopax:phosphositeplus
No evidence text available
CDK2 phosphorylates USP37 on S858. 1 / 1
| 1
sparser
"When the de-ubiquitinating enzyme ubiquitin specific peptidase 37 (USP37) is phosphorylated by cyclin dependent kinase 2 (CDK2) at Ser858 it can bind to SCF- β TrCP for ubiquitination and degradation in G2."
33643814
CDK2 activates USP37.
| 5 3
CDK2 activates USP37. 8 / 9
| 5 3
reach
"Deubiquitinase USP37 is activated by CDK2 to antagonize APC (CDH1) and promote S phase entry [XREF_BIBR]."
25972356
reach
"Deubiquitinase USP37 is activated by CDK2 to antagonize APC (CDH1) and promote S phase entry."
21596315
reach
"Since USP37 S 628 exists within a minimum CDK phosphorylation motif (S/T-P) (Dephoure et al., 2008), CDK2 interacts with USP37, and CDK2 is active in G1/S, we investigated whether CDK2 phosphorylates [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
reach
"Overexpression of CDK2 activating cyclin A or E increased USP37 activity toward HA-Ubi-VS, whereas cyclins B and D were without effect, suggesting that USP37 is one of several CDK2 substrates that int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
sparser
"We found this interesting because USP37 has been implicated in cell proliferation and transformation [ 6, 7 ] as well as in cell-cycle regulation, where during the G1/S transition, CDK2 phosphorylates[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
sparser
"The role of cysteine 350 in USP37 was first illustrated by Huang et al. in 2011, in which they found that CDK2 activates USP37 to antagonize APC (CDH1) and promote S phase entry and that USP37 deubiquitinates CDT1 [ xref ]."
| PMC
reach
"There is positive reinforcement of this signaling mechanism because phosphorylation of Ser 628 by CDK2 and cyclin E and CDK2 and cyclin A complexes produces maximal USP37 activity, and USP37 activates[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
sparser
"Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry [ xref ]."
25972356
CDK2 binds USP37.
2 | 1 1
CDK2 binds USP37. 4 / 4
2 | 1 1
biogrid
No evidence text available
21596315
biogrid
No evidence text available
26299517
sparser
"Since USP37 S 628 exists within a minimum CDK phosphorylation motif (S/T-P) ( Dephoure et al., 2008 ), CDK2 interacts with USP37 ( Figure 1 C), and CDK2 is active in G1/S, we investigated whether CDK[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
reach
"Since USP37 S 628 exists within a minimum CDK phosphorylation motif (S/T-P) (Dephoure et al., 2008), CDK2 interacts with USP37, and CDK2 is active in G1/S, we investigated whether CDK2 phosphorylates [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
CDK2 dephosphorylates USP37.
| 1
CDK2 dephosphorylates USP37. 1 / 1
| 1
reach
"In late mitosis, CDK2 is no longer active, and thus the APC–CDH1 complex reforms and dephosphorylated USP37 switches from an antagonist to a substrate of the APC-CDH1 complex (Fig. 1)."
| PMC
USP37 affects SNAI1
| 10 19
USP37 binds SNAI1.
| 4 18
SNAI1 binds USP37. 10 / 22
| 4 18
reach
"They transfected plasmids encoding 79 DUBs into 293 T cells expressing Flag-SNAI1 and found that USP37 predominantly interacts and stabilizes SNAI1 by causing its deubiquitination."
| PMC
sparser
"Overexpression of USP37 in SGC7901-shRNA cells restores Snail1 protein levels, which shows that the USP37-Snail1 axis plays a vital role in PLAGL2-mediated Snail1 stabilization."
33391500
sparser
"Deubiquitinase USP37 Interacts With Snail."
31998374
sparser
"Co-IP results showed that GSK-3β siRNAs diminished approximately 60% of the interaction of USP37 and Snail1 (Figure xref D)."
33391500
sparser
"To map the binding protein domains for Snail1 interacting with USP37, we constructed a series of HA-Snail1 truncations and found that the serine-rich domain (SRD) within Snail1 is required for its interaction with USP37 (Figure xref G-H)."
33391500
sparser
"We further investigated the interaction between USP37 and Snail1."
33391500
reach
"USP37 directly binds, deubiquitinates, and stabilizes SNAI1."
31911859
reach
"Of these three DUBs, USP37 binds SNAI1 most strongly and plays a major role in stabilizing SNAI1 and thereby promoting cancer cell migration, E cadherin downregulation, and vimentin upregulation."
| PMC
reach
"Removal of phosphate groups from SNAI1 with a dephosphorylase enzyme reduces the interaction between USP37 and SNAI1; therefore, phosphorylation is required for their interaction."
| PMC
sparser
"The specific GSK-3β siRNAs were further used to investigate the role of GSK-3β in the interaction between Snail1 and the USP37 protein."
33391500
USP37 deubiquitinates SNAI1.
| 4
USP37 deubiquitinates SNAI1. 4 / 4
| 4
reach
"USP37 deubiquitinates Snail protein, prevents the degradation of Snail, and stabilizes the initially unstable Snail protein."
34405018
reach
"Our studies demonstrate that a deubiquitinating enzyme (DUB) family member, USP37, can deubiquitinate Snail and prevent degradation of Snail."
31998374
reach
"Microarray analysis of total RNA isolated from stable PLAGL2 knockdown (SGC7901-shRNA) and SGC7901 NC cells elucidated three differentially expressed DUBs, of which only USP37 directly interacted and significantly diminished the ubiquitination of SNAI1."
| PMC
reach
"Subsequent sub-screening identified 23 DUBs that interact with SNAI1, out of which USP29, USP36, and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein."
| PMC
USP37 ubiquitinates SNAI1.
| 1
USP37 ubiquitinates SNAI1. 1 / 1
| 1
sparser
"Accordingly, silencing endogenous USP37 promoted Snail1 ubiquitination in the presence or absence of MG132 (Figure xref I-J)."
33391500
USP37 increases the amount of SNAI1.
| 1
USP37 increases the amount of SNAI1. 1 / 1
| 1
reach
"As shown in Fig. 3c and d, knockdown of USP37 significantly decreased Snail1, N-cadherin and Vimentin expression, but increased E-cadherin expression levels."
30482232
USP37 activates SNAI1.
| 1
USP37 activates SNAI1. 1 / 1
| 1
reach
"USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein"
31998374
CDH1 affects USP37
| 12 17
CDH1 binds USP37.
| 10 15
CDH1 binds USP37. 10 / 21
| 9 12
sparser
"Knockdown of CDH1 markedly reduced the interaction between USP37 and CDC27 ( Figure 1 F), suggesting that core APC/C components bind USP37 indirectly through CDH1."
21596315
sparser
"We show that the deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A."
21596315
sparser
"They identified interactions between USP37 and CDH1, as well as APC/C subunits, implicating USP37 in the regulation of the G1/S transition and characterized the cell cycle regulation of USP37 ( xref )."
34109183
reach
"We show that the deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A. USP37 was induced by E2F transcription factors in G1, peaked at G1/S, and was degraded in late mitosis."
21596315
sparser
"A direct interaction between USP37 and CDH1 is likely because mixing of USP37 and CDH1 translated individually in rabbit reticulocyte lysates reproduced the interaction observed in cells ( Figure 1 G)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
reach
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
reach
"A direct interaction between USP37 and CDH1 is likely because mixing of USP37 and CDH1 translated individually in rabbit reticulocyte lysates reproduced the interaction observed in cells."
21596315
reach
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
sparser
"USP37 binds to the substrate adaptor CDH1 and removes the polyubiquitin chain, which is the degradation signal, from cyclin A ( xref )."
34177595
sparser
"Usp37 binds APC/C Cdh1 in G1 and deubiquitinates the APC/C substrate cyclin A [ xref ]."
21978762
APC_C binds CDH1 and USP37. 1 / 1
| 1
sparser
"The core components of APC bind with USP37 through CDH1."
| PMC
CDC20 binds CDH1 and USP37. 1 / 1
| 1
sparser
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
CDH1 binds mutated USP37. 1 / 1
| 1
reach
"Consistent with this degron being targeted by APC CDH1, the KEN box-3 mutant USP37 interacted poorly with CDH1 and had a much longer half-life."
21596315
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
CDH1 ubiquitinates USP37.
| 2
CDH1 ubiquitinates USP37. 2 / 2
| 2
sparser
"Further evidence for USP37 deubiquitinating itself is that APC CDH1 could ubiquitinate USP37 in vitro only if the catalytic Cys 350 was mutated or inhibited by ubiquitin-aldehyde ( Figure 6 C)."
21596315
sparser
"Inactive USP37 is ubiquitinated by E3 ubiquitin ligase APC CDH1 and degraded in the proteasome ( xref )."
33169399
CDH1 inhibits USP37.
| 2
CDH1 inhibits USP37. 2 / 2
| 2
reach
"CDH1 promoted USP37 degradation except when the KEN box-3 was mutated."
21596315
reach
"Overexpression of CDH1, but not CDC20, beta-TRCP1, or beta-TRCP2, decreased endogenous USP37 in 293T cells."
21596315
USP37 affects MYC
4 1 | 3 12 5
USP37 binds MYC.
4 | 1 1 5
USP37 binds MYC. 10 / 11
4 | 1 1 4
biogrid
No evidence text available
25284584
biogrid
No evidence text available
25284584
sparser
"Given the structural properties of the interaction sites in the c-MYC-USP37 complex, a peptidyl inhibitor has been designed."
36985413
sparser
"Interestingly, unlike USP28 [ xref ], USP37 directly binds to c-Myc and acts independently of Fbw37."
34201062
reach
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity dependent manner."
25284584
trips
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity-dependent manner."
25284584
sparser
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity-dependent manner."
25284584
biogrid
No evidence text available
25284584
biogrid
No evidence text available
25284584
sparser
"Investigating In Situ Expression of c-MYC and Candidate Ubiquitin-Specific Proteases in DLBCL and Assessment for Peptidyl Disruptor Molecule against c-MYC-USP37 Complex."
36985413
USP37 binds MYC, Hemagglutinins, and 14-3-3γ. 1 / 1
| 1
sparser
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3γ and Myc-USP37."
26427597
USP37 deubiquitinates MYC.
1 | 2 7
USP37 deubiquitinates MYC. 10 / 10
1 | 2 7
reach
"Lastly, USP37 deubiquitinates and stabilizes the proto-oncogene c-Myc and the oncogenic fusion PLZF-RARA, suggesting that inhibition of USP37 DUB activity could have therapeutic potential XREF_BIBR, XREF_BIBR."
30858488
reach
"It is worth mentioning that USP37 also deubiquitinates and stabilizes c-Myc to affect proliferation in cancer cells82."
34405018
reach
"Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37."
29263902
reach
"USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer."
25284584
reach
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity dependent manner."
25284584
ubibrowser
"Review"
27919796
reach
"An early study showed that USP28 deubiquitinates c-Myc via interacting with Fbw7alpha whereas a recent study reveals that USP37 deubiquitinates c-Myc independently of Fbw7 and c-Myc phosphorylation."
26697836
reach
"Pan et al. reported that high levels of USP37 gene expression in lung cancer promoted cell viability as well as the Warburg effect via deubiquitination and stabilization of pluripotent factor c-Myc protein [21]."
30482232
trips
"USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer."
25284584
trips
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity-dependent manner."
25284584
USP37 activates MYC.
| 2
USP37 activates MYC. 2 / 4
| 2
reach
"The overexpression of USP37 markedly increases c-Myc abundance by blocking its degradation, whereas the depletion of USP37 promotes c-Myc degradation and reduces c-Myc levels."
25284584
reach
"XREF_BIBR - XREF_BIBR Moreover, the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc."
32140262
USP37 increases the amount of MYC.
| 1
USP37 increases the amount of MYC. 1 / 1
| 1
reach
"The deubiquitinating enzyme USP37 promotes keloid fibroblasts proliferation and collagen production by regulating the c-Myc expression."
36333840
USP37 decreases the amount of MYC.
| 1
USP37 decreases the amount of MYC. 1 / 1
| 1
reach
"The overexpression of USP37 markedly increases c-Myc abundance by blocking its degradation, whereas the depletion of USP37 promotes c-Myc degradation and reduces c-Myc levels."
25284584
USP37 affects CDT1
1 1 | 2 18 2
USP37 deubiquitinates CDT1.
1 | 6
USP37 deubiquitinates CDT1. 7 / 7
1 | 6
ubibrowser
"USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication."
27296872
reach
"USP37 regulates DNA replication by deubiquitinating CDT1, an important protein in DNA replication, but USP37 may control many unknown factors at replication forks that should be further explored [48]."
| PMC
reach
"The role of cysteine 350 in USP37 was first illustrated by Huang et al. in 2011, in which they found that CDK2 activates USP37 to antagonize APC (CDH1) and promote S phase entry and that USP37 deubiquitinates CDT1 [19]."
| PMC
reach
"USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication."
27296872
reach
"USP37 induces deubiquitination of CDT1, whereas a catalytically inactive (C350S) USP37 mutant is unable to ubiquitinate CDT1, further suggesting that USP37 plays a role in CDT1 stabilization."
| PMC
reach
"USP37 interacted with and deubiquitinated CDT1 to protect it from proteasomal degradation."
33898105
reach
"USP37 interacts with Cdt1 and is able to de-ubiquitinate Cdt1 invivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin."
27296872
USP37 binds CDT1.
1 | 3 2
USP37 binds CDT1. 6 / 7
1 | 3 2
reach
"In order to confirm this hypothesis, we performed a co-immunoprecipitation assay followed by an immunoblotting analysis, detecting CDT1 and USP37, respectively, in order to evaluate the interactions between USP37 and CDT1."
33898105
sparser
"In order to confirm this hypothesis, we performed a co-immunoprecipitation assay followed by an immunoblotting analysis, detecting CDT1 and USP37, respectively, in order to evaluate the interactions between USP37 and CDT1."
33898105
reach
"USP37 interacted with and deubiquitinated CDT1 to protect it from proteasomal degradation."
33898105
biogrid
No evidence text available
27296872
reach
"USP37 interacts with Cdt1 and is able to de-ubiquitinate Cdt1 invivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin."
27296872
sparser
"Therefore, we further examined the 6 enriched genes in this pathway using an online tool (Chipbase) and found that USP37 and CDT1 were closely associated with lung cancer ( xref D)."
33898105
USP37 increases the amount of CDT1.
| 5
USP37 increases the amount of CDT1. 5 / 5
| 5
reach
"Using an overexpression screen of 78 human ubiquitin and ubiquitin-like hydrolases, Perez et al. reported that USP37 increases CDT1 levels when cells are exposed to DNA-damaging agents while USP37 depletion with siRNA decreases CDT1 protein levels [48]."
| PMC
reach
"Moreover, previous evidence has shown that USP37 promotes the expression of CDT1."
33898105
reach
"The results revealed that the overexpression of USP37 increased CDT1 protein levels and USP37 silencing decreased CDT1 expressions (XREF_FIG I and 5J)."
33898105
reach
"To understand whether the regulation of CDT1 expression by USP37 plays a role in lung cancer cell growth and invasion, the expressions of miR-320b and/or CDT1 in lung cancer cells (A549 and H1650) were altered."
33898105
reach
"The results illustrated that USP37 knockdown significantly reduced CDT1 protein levels while lysosomal inhibitor (MG132) preserved the CDT1 protein (XREF_FIG M)."
33898105
USP37 activates CDT1.
| 2 1
USP37 activates CDT1. 3 / 3
| 2 1
eidos
"Moreover , previous evidence has shown that USP37 promotes the expression of CDT1 ."
33898105
reach
"Thus, we hypothesized that USP37 may contribute to the tumorigenesis of lung cancer by regulating CDT1."
33898105
eidos
"Using an overexpression screen of 78 human ubiquitin and ubiquitin-like hydrolases , Perez et al. reported that USP37 increases CDT1 levels when cells are exposed to DNA-damaging agents while USP37 depletion with siRNA decreases CDT1 protein levels [ 48 ] ."
| PMC
USP37 ubiquitinates CDT1.
| 1
USP37 ubiquitinates CDT1. 1 / 1
| 1
reach
"USP37 induces deubiquitination of CDT1, whereas a catalytically inactive (C350S) USP37 mutant is unable to ubiquitinate CDT1, further suggesting that USP37 plays a role in CDT1 stabilization."
| PMC
USP37 inhibits CDT1.
| 1
USP37 inhibits CDT1. 1 / 1
| 1
reach
"To explore whether USP37 mediates the proteasomal degradation of CDT1, we treated USP37 silencing cells with MG132 or dimethyl sulfoxide (DMSO) and detected the expression of CDT1 afterward."
33898105
USP37 decreases the amount of CDT1.
| 1
USP37 decreases the amount of CDT1. 1 / 1
| 1
reach
"The results revealed that the overexpression of USP37 increased CDT1 protein levels and USP37 silencing decreased CDT1 expressions (XREF_FIG I and 5J)."
33898105
USP37 affects WAPL
3 | 10 9
USP37 binds WAPL.
3 | 5 9
USP37 binds WAPL. 10 / 16
3 | 5 8
reach
"USP37 interacts with WAPL, a negative regulator of cohesion, through its UIMs and regulates the stability of chromatin associated WAPL."
26299517
biogrid
No evidence text available
26299517
sparser
"Lastly, mutation of UIM2 and/or UIM3 perturbed USP37 binding to the cohesin regulator WAPL and to endogenous Ub-protein conjugates xref , xref ."
30858488
sparser
"USP37 interacts with WAPL, a negative regulator of cohesion, through its UIMs and regulates the stability of chromatin-associated WAPL."
26299517
biogrid
No evidence text available
26299517
sparser
"However, because both USP37 and WAPL negatively regulate cohesion, we hypothesized that USP37 may interact with WAPL to facilitate sister chromatid resolution."
26299517
sparser
"Further, USP37 associates with WAPL, a negative regulator of cohesion necessary for cohesin release in prophase, in a manner dependent on USP37's second and third ubiquitin-interacting motifs."
26299517
biogrid
No evidence text available
26299517
reach
"These results confirm the contribution of UIM2 and UIM3 of USP37 to binding ubiquitin conjugates in vitro and, in particular, to mediating an interaction with WAPL in vivo.Because the interaction betw[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
reach
"However, because both USP37 and WAPL negatively regulate cohesion, we hypothesized that USP37 may interact with WAPL to facilitate sister chromatid resolution."
26299517
Cohesin binds USP37 and WAPL. 1 / 1
| 1
sparser
"The authors further demonstrated that USP37 interacts with both cohesin and a negative regulator WAPL, which is required for releasing cohesin from chromatid arms in prophase."
32201366
USP37 deubiquitinates WAPL.
| 3
USP37 deubiquitinates WAPL. 3 / 3
| 3
reach
"Importantly, when USP37 WT, but not USP37 C350A, is added, ubiquitylation is reduced, indicating that USP37 can directly deubiquitylate WAPL and/or WAPL associated proteins in vitro."
26299517
reach
"Next, to investigate whether USP37 can directly deubiquitylate WAPL, we purified full-length USP37 WT and USP37 C350A from Sf9 insect cells and added either USP37 WT, USP37 C350A, or buffer alone to a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
reach
"WAPL is pulled down with His Ub under denaturing conditions in all tested treatments, indicating that ubiquitylated WAPL is detected throughout the cell cycle.We expected that, if USP37 deubiquitylate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
USP37 activates WAPL.
| 2
USP37 activates WAPL. 2 / 2
| 2
reach
"Given the critical role of WAPL in the prophase pathway, it will be interesting to discern whether USP37 contributes to other WAPL dependent processes, such as chromatin structure or protecting cohesi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
reach
"Depletion of USP37 reduces the stability of chromatin associated WAPL and increases the fraction of WAPL that is more heavily ubiquitylated in mitosis."
26299517
USP37 affects Snail1
| 22
USP37 binds Snail1.
| 12
USP37 binds Snail1. 10 / 12
| 12
reach
"To explore whether the interaction between Snail1 and USP37 requires Snail1 phosphorylation, we utilized CIP to remove phosphate groups from the substrate proteins."
33391500
reach
"We further investigated the interaction between USP37 and Snail1."
33391500
reach
"Since GSK-3beta is the major kinase involved in Snail1 phosphorylation in the SRD region, the GSK-3beta inhibitor LiCl was used to assess GSK-3beta inhibition in the interaction of USP37 and Snail1."
33391500
reach
"As shown in Figure XREF_FIG B, LiCl treatment also significantly disrupted the USP37 and Snail1 interaction."
33391500
reach
"Co-IP results showed that GSK-3beta siRNAs diminished approximately 60% of the interaction of USP37 and Snail1."
33391500
reach
"We also determined that USP37 interacts with and deubiquitinates Snail1 directly, which is transcriptionally activated by PLAGL2."
33391500
reach
"Therefore, the SRD domain is also crucial for USP37 mediated Snail1 deubiquitination and the interaction between USP37 and Snail1."
33391500
reach
"Overall, these results demonstrate that USP37 interacts with and deubiquitinates Snail1 directly."
33391500
reach
"Strikingly, Co-IP experiments showed that the interaction between USP37 and Snail1 was strongly impeded by CIP intervention."
33391500
reach
"However, in cells with high expression of USP37, phosphorylated Snail1 promotes the mutual binding of USP37 and Snail1, and the ability of USP37 to bind to phosphorylated Snail1 is significantly enhanced."
33391500
USP37 deubiquitinates Snail1.
| 6
USP37 deubiquitinates Snail1. 5 / 5
| 5
reach
"Among these three DUBs, only USP37 significantly diminished the ubiquitination of Snail1, suggesting that USP37 may be a potential deubiquitinase of Snail1."
33391500
reach
"Although PLAGL2 does not function as a deubiquitinase to impede Snail1 ubiquitination, PLAGL2 transcriptionally activates USP37, which finally interacts with and deubiquitinates Snail1 directly."
33391500
reach
"USP37 interacts with and deubiquitinates Snail1 directly."
33391500
reach
"We also determined that USP37 interacts with and deubiquitinates Snail1 directly, which is transcriptionally activated by PLAGL2."
33391500
reach
"Overall, these results demonstrate that USP37 interacts with and deubiquitinates Snail1 directly."
33391500
Modified USP37 leads to the deubiquitination of Snail1. 1 / 1
| 1
reach
"Overexpression of USP37 significantly reduced the endogenous ubiquitination of Snail1 in the AGS cells."
33391500
USP37 activates Snail1.
| 3
USP37 activates Snail1. 3 / 3
| 3
reach
"Besides, we showed that PLAGL2 directly activates USP37 expression, which targets Snail1 to proteasome ubiquitination degradation."
33391500
reach
"Furthermore, we confirmed the role of GSK-3beta in the USP37 mediated stabilization of Snail1."
33391500
reach
"USP37 considerably increased the stability and half-life of Snail1 in the AGS cells."
33391500
USP37 ubiquitinates Snail1.
| 1
USP37 leads to the ubiquitination of Snail1. 1 / 1
| 1
reach
"Accordingly, silencing endogenous USP37 promoted Snail1 ubiquitination in the presence or absence of MG132."
33391500
SNAI1 affects USP37
| 4 18
SNAI1 binds USP37. 10 / 22
| 4 18
reach
"They transfected plasmids encoding 79 DUBs into 293 T cells expressing Flag-SNAI1 and found that USP37 predominantly interacts and stabilizes SNAI1 by causing its deubiquitination."
| PMC
sparser
"Overexpression of USP37 in SGC7901-shRNA cells restores Snail1 protein levels, which shows that the USP37-Snail1 axis plays a vital role in PLAGL2-mediated Snail1 stabilization."
33391500
sparser
"Deubiquitinase USP37 Interacts With Snail."
31998374
sparser
"Co-IP results showed that GSK-3β siRNAs diminished approximately 60% of the interaction of USP37 and Snail1 (Figure xref D)."
33391500
sparser
"To map the binding protein domains for Snail1 interacting with USP37, we constructed a series of HA-Snail1 truncations and found that the serine-rich domain (SRD) within Snail1 is required for its interaction with USP37 (Figure xref G-H)."
33391500
sparser
"We further investigated the interaction between USP37 and Snail1."
33391500
reach
"USP37 directly binds, deubiquitinates, and stabilizes SNAI1."
31911859
reach
"Of these three DUBs, USP37 binds SNAI1 most strongly and plays a major role in stabilizing SNAI1 and thereby promoting cancer cell migration, E cadherin downregulation, and vimentin upregulation."
| PMC
reach
"Removal of phosphate groups from SNAI1 with a dephosphorylase enzyme reduces the interaction between USP37 and SNAI1; therefore, phosphorylation is required for their interaction."
| PMC
sparser
"The specific GSK-3β siRNAs were further used to investigate the role of GSK-3β in the interaction between Snail1 and the USP37 protein."
33391500
USP37 affects BLM
| 19 2
USP37 binds BLM.
| 8 2
BLM binds USP37. 10 / 10
| 8 2
reach
"Here, we demonstrate that the deubiquitinating enzyme USP37 interacts with BLM and that USP37 deubiquitinates and stabilizes BLM, thereby sustaining the DNA damage response (DDR)."
34606619
reach
"We found that only HA-tagged USP37 bound with endogenous BLM (Figure 1A)."
34606619
reach
"In addition, we examined the endogenous interaction between USP37 and BLM in HEK293T cells and confirmed that USP37 interacted with BLM (Figure 1C, D)."
34606619
reach
"Mechanistically, USP37 is phosphorylated by ATM following DNA damage, which increases the binding between USP37 and BLM and leads to BLM deubiquitylation."
34606619
sparser
"Collectively, our results establish a novel molecular mechanism for the USP37-BLM axis in regulating DSB repair with an important role in chemotherapy and radiotherapy response in human cancers."
34606619
reach
"Mechanistically, DNA double-strand breaks (DSB) promotes ATM phosphorylation of USP37 and enhances the binding between USP37 and BLM."
34606619
reach
"Collectively, these results indicate that DNA damage can strengthen the interaction between USP37 and BLM, which in turn stabilizes BLM."
34606619
reach
"We found that S114A mutation attenuated the interaction between USP37 and BLM (Figure 5E)."
34606619
reach
"To support this notion, we found that the interaction between USP37 and BLM was enhanced upon cisplatin treatment in cells (Figure 4D)."
34606619
sparser
"Here, we demonstrate that the deubiquitinating enzyme USP37 interacts with BLM and that USP37 deubiquitinates and stabilizes BLM, thereby sustaining the DNA damage response (DDR)."
34606619
USP37 deubiquitinates BLM.
| 7
USP37 deubiquitinates BLM. 7 / 7
| 7
reach
"Correction to 'USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM'."
36744478
reach
"USP37 deubiquitinates BLM in vivo and in vitro."
34606619
reach
"Moreover, knockdown of USP37 increases BLM polyubiquitination, accelerates its proteolysis, and impairs its function in DNA damage response."
34606619
reach
"In this study, we demonstrate that USP37 deubiquitinates and stabilizes BLM."
34606619
reach
"In addition, WT USP37, but not the CA mutant, decreased BLM polyubiquitination in vitro (Figure 3D, and Supplementary Figure S2A, B)."
34606619
reach
"Since USP37 inhibits the ubiquitination of BLM following DNA damage, we further explored whether and how USP37 itself is regulated following DNA damage."
34606619
reach
"Here, we demonstrate that the deubiquitinating enzyme USP37 interacts with BLM and that USP37 deubiquitinates and stabilizes BLM, thereby sustaining the DNA damage response (DDR)."
34606619
USP37 activates BLM.
| 4
USP37 activates BLM. 4 / 4
| 4
reach
"Mechanistically, DNA damage activates ATM which phosphorylates USP37 and activates its deubiquitinase activity to stabilize BLM."
34606619
reach
"USP37-promoted BLM stabilization is potentiated by DNA damage."
34606619
reach
"Interestingly, WT USP37 was phosphorylated by ATM, which in turn increased its deubiquitination activity towards BLM, while the S114A mutant did not have this effect."
34606619
reach
"USP37 promotes BLM stabilization."
34606619
WAPL affects USP37
3 | 5 9
USP37 binds WAPL. 10 / 16
3 | 5 8
reach
"USP37 interacts with WAPL, a negative regulator of cohesion, through its UIMs and regulates the stability of chromatin associated WAPL."
26299517
biogrid
No evidence text available
26299517
sparser
"Lastly, mutation of UIM2 and/or UIM3 perturbed USP37 binding to the cohesin regulator WAPL and to endogenous Ub-protein conjugates xref , xref ."
30858488
sparser
"USP37 interacts with WAPL, a negative regulator of cohesion, through its UIMs and regulates the stability of chromatin-associated WAPL."
26299517
biogrid
No evidence text available
26299517
sparser
"However, because both USP37 and WAPL negatively regulate cohesion, we hypothesized that USP37 may interact with WAPL to facilitate sister chromatid resolution."
26299517
sparser
"Further, USP37 associates with WAPL, a negative regulator of cohesion necessary for cohesin release in prophase, in a manner dependent on USP37's second and third ubiquitin-interacting motifs."
26299517
biogrid
No evidence text available
26299517
reach
"These results confirm the contribution of UIM2 and UIM3 of USP37 to binding ubiquitin conjugates in vitro and, in particular, to mediating an interaction with WAPL in vivo.Because the interaction betw[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
reach
"However, because both USP37 and WAPL negatively regulate cohesion, we hypothesized that USP37 may interact with WAPL to facilitate sister chromatid resolution."
26299517
Cohesin binds USP37 and WAPL. 1 / 1
| 1
sparser
"The authors further demonstrated that USP37 interacts with both cohesin and a negative regulator WAPL, which is required for releasing cohesin from chromatid arms in prophase."
32201366
reach
"Depletion of USP37 also reduced cellular proliferation and led to increased sensitivity to agents that induce replication stress."
34509474
reach
"USP37 promotes cell proliferation by stabilizing 14-3-3gamma."
26427597
reach
"XREF_BIBR Therefore, it is possible that IH mediated miR-320b reduction in lung cancer cells resulted in the upregulation of USP37, which further promoted cancer cell proliferation, invasion, and survival."
33898105
reach
"We found that lower expression level of USP37 obviously impaired the expression of Hh targets (Smo and Gli-1) and cell proliferation marker Ki-67 in the tumor tissues as seen by immunohistochemical staining (Fig. 8e)."
30482232
eidos
"Knockdown of USP37 inhibits cell proliferation and induces apoptosis To investigate the latent role of USP37 gene in the transformation of breast cancer cells , cell proliferation was examined by CCK-8 assay ."
33390801
reach
"Accumulating evidence has demonstrated that USP37 promotes lung cancer cell proliferation, migration, and invasion XREF_BIBR but inhibits lung cancer cell apoptosis in a deubiquitination dependent manner."
33898105
reach
"Notably, our results showed that overexpression of USP37, but not USP37 (C350S), enhanced the proliferation of cancer cells when 14-3-3gamma was co-transfected."
26427597
reach
"On the other hand, USP37 shRNAs inhibited the proliferation of keloid fibroblasts with diminished c-Myc and Collagen I expression."
36333840
USP37 bound to HA-14-3-3gamma activates cell population proliferation. 1 / 1
| 1
reach
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3gamma and Myc-USP37."
26427597
USP37-C350S activates cell population proliferation. 1 / 1
| 1
reach
"Notably, our results showed that overexpression of USP37, but not USP37 (C350S), enhanced the proliferation of cancer cells when 14-3-3gamma was co-transfected."
26427597
reach
"Since concomitant loss of REST and USP37 expression attenuated p27 stabilization and differentiation and rescued cell proliferation, our data strongly suggest that repression of USP37 and consequent p27 degradation, are important for REST dependent maintenance of cell proliferation."
22665064
reach
"These findings indicate that ectopic USP37 not only blocked REST dependent cell proliferation, but also countered the blockade to neuronal differentiation even in the presence of REST."
22665064
eidos
"Functionally , downregulated USP37 decreases cell proliferation and anchorage-independent growth [ 28 ] ."
| PMC
reach
"Functionally, USP37 depletion causes decreased cell proliferation measured by MTS, two-dimensional (2D) colony formation as well as three-dimensional (3D) anchorage- independent growth."
32461361
reach
"Functionally, downregulated USP37 decreases cell proliferation and anchorage-independent growth [28]."
| PMC
USP37 activates epithelial to mesenchymal transition. 10 / 15
| 7 8
eidos
"These data confirm that USP37 mediates breast cancer stem-like properties , cell invasion and EMT via the Hh pathway ."
30482232
eidos
"USP37 is a modulator of the epithelial-mesenchymal transition and metastasis ."
| PMC
eidos
"USP37 knockdown inhibits stemness , cell invasion and EMT via Hedgehog signaling pathway in breast cancer ."
30482232
reach
"Snail protein is an essential positive regulator of EMT, which is upregulated by USP37."
34405018
reach
"On the contrary, upregulation of USP37 promoted EMT, migration and invasion."
30482232
reach
"In order to understand the mechanism of USP37-induced EMT and stemness via the Hh pathway, we treated MCF-7 cells with PM."
30482232
eidos
"Therefore , USP37 promotes EMT via the SHH pathway , and the signalling outcomes are determined by the balance of activated and inhibitory GLI1 proteins [ 39 ] ."
| PMC
eidos
"The knockdown of USP37 could inhibit the stemness , cell invasion and EMT via downregulation of Hedgehog pathway ."
30482232
eidos
"Knockdown of USP37 expression hampered cell invasion , stemness , EMT and also resulted in the drug sensitivity to cisplatin ."
30482232
reach
"Further studies indicated that USP37 knockdown could inhibit the stemness, cell invasion and EMT in breast cancer via downregulation of Hh pathway."
30482232
USP37 inhibits epithelial to mesenchymal transition. 1 / 1
| 1
reach
"Downregulation of USP37 inhibits stemness, cell invasion and EMT via hedgehog signaling pathway in breast cancer."
30482232
USP37 affects Neoplasm Invasiveness
| 3 12
USP37 activates Neoplasm Invasiveness.
| 3 10
USP37 activates Neoplasm Invasiveness. 10 / 13
| 3 10
reach
"In contrast, USP37 upregulation promotes EMT, migration, and invasion [39]."
| PMC
reach
"We previously demonstrated that ubiquitin carboxyl-terminal hydrolase 37 (UCH37), a member of the DUBs, promoted invasion and postoperative recurrence of HCC, and pre-mRNA processing factor 19 (Prp19) may function as its downstream effecter [XREF_BIBR]."
26959880
reach
"The knockdown of USP37 could inhibit the stemness, cell invasion and EMT via downregulation of Hedgehog pathway."
30482232
reach
"Accumulating evidence has demonstrated that USP37 promotes lung cancer cell proliferation, migration, and invasion XREF_BIBR but inhibits lung cancer cell apoptosis in a deubiquitination dependent manner."
33898105
reach
"On the contrary, upregulation of USP37 promoted EMT, migration and invasion."
30482232
eidos
"On the contrary , upregulation of USP37 promoted EMT , migration and invasion ."
30482232
reach
"Further studies indicated that USP37 knockdown could inhibit the stemness, cell invasion and EMT in breast cancer via downregulation of Hh pathway."
30482232
reach
"Furthermore, upregulation of USP37 markedly promoted invasion and migration of breast cancer cells (Fig. 3k and l)."
30482232
reach
"XREF_BIBR Therefore, it is possible that IH mediated miR-320b reduction in lung cancer cells resulted in the upregulation of USP37, which further promoted cancer cell proliferation, invasion, and survival."
33898105
eidos
"In contrast , USP37 upregulation promotes EMT , migration , and invasion [ 39 ] ."
| PMC
USP37 inhibits Neoplasm Invasiveness. 2 / 2
| 2
reach
"Downregulation of USP37 inhibits stemness, cell invasion and EMT via hedgehog signaling pathway in breast cancer."
30482232
reach
"A study by Qin et al. reported that USP37 KD suppresses BC and BC stem cell migration and invasion by promoting the mesenchymal-epithelial transition (MET) by markedly reducing the SNAI1, N-cadherin, and vimentin expression and increasing the E-cadherin."
| PMC
X affects USP37
| 1 13
X activates USP37.
| 6
X activates USP37. 6 / 6
| 6
reach
"Many recent studies have highlighted the significant role of E3 ubiquitin ligases, deubiquitinases or substrate translocation between cell compartments, leading to substrate stability motivated us to explore the effect of HBx driven exodus of USP37 from the nucleus vis-a-vis its intracellular stability."
25347529
reach
"Conversely, HBx rescued USP37 from CDH1 mediated down-regulation similar to CDC6 but not the other CDH1 substrate, Geminin XREF_BIBR (XREF_FIG)."
25347529
reach
"HBx of HBV could upregulate USP37 transcripts in both hepatic and non-hepatic cells and also prevents USP37 from proteasomal degradation."
30510918
reach
"Thus, we wondered if the effect of DUB inhibitor on SIRT7 protein levels observed in presence of HBx was dependent upon HBx mediated up-regulation of USP37."
26442981
reach
"Ironically, Emi1 overexpression did not lead to USP37 accumulation thereby mitigating the possible role of Emi1 in HBx mediated USP37 stabilization."
25347529
reach
"The HBx dependent up-regulation of USP37 could be seen even in non hepatic cells such as HEK293T and U2OS."
25347529
X inhibits USP37.
| 1 2
X inhibits USP37. 3 / 3
| 1 2
reach
"HBx of HBV could upregulate USP37 transcripts in both hepatic and non-hepatic cells and also prevents USP37 from proteasomal degradation."
30510918
eidos
"HBx of HBV could upregulate USP37 transcripts in both hepatic and non-hepatic cells and also prevents USP37 from proteasomal degradation ."
30510918
reach
"As expected, overexpression of HBx unlike NESM mutant abrogated the interaction of USP37 with its cognate E3 ligases- CDH1 and beta-TrCP (XREF_FIG)."
25347529
X increases the amount of USP37.
| 3
X increases the amount of USP37. 3 / 3
| 3
reach
"Thus, by stabilizing the expression of USP37, HBx promotes the accumulation of cyclin A to modulate cell cycle progression."
30510918
reach
"HBx was also found to stimulate the gene transcription and protein expression of USP37."
25347529
reach
"HBx augments the expression of USP37."
25347529
X ubiquitinates USP37.
| 1
X leads to the ubiquitination of USP37. 1 / 1
| 1
reach
"HBx directly attenuated the ubiquitination and subsequent proteasomal degradation of USP37 which could be reversed by RNA interference against HBx."
25347529
X deubiquitinates USP37.
| 1
X leads to the deubiquitination of USP37. 1 / 1
| 1
reach
"As HBx could effectively prevent the ubiquitination of USP37, we assessed the regulation of its E3 ubiquitin ligases- CDH1 and beta-TrCP in the presence of HBx."
25347529
USP37 affects CDKN1B
1 | 7 6
USP37 binds CDKN1B.
| 1 5
CDKN1B binds USP37. 6 / 6
| 1 5
sparser
"USP37 formed a complex with p27, promoted its deubiquitination and stabilization, and blocked cell proliferation [ xref ]."
34072267
sparser
"Ectopically expressed USP37 formed a complex with p27, promoted its stabilization, blocked cell proliferation and induced the expression of REST-target neuronal differentiation genes."
22665064
reach
"Interaction between USP37 and p27 was also confirmed by co-immunoprecipitation experiments using anti-p27 antibodies or control IgG followed by Western blot analysis using anti-Ub antibodies."
22665064
sparser
"Ectopically expressed wild type USP37 formed a complex with p27, promoted its deubiquitination and stabilization and blocked cell proliferation."
22665064
sparser
"Interaction between USP37 and p27 was also confirmed by co-immunoprecipitation experiments using anti-p27 antibodies or control IgG followed by Western blot analysis using anti-Ub antibodies."
22665064
sparser
"In medulloblastomas, REST expression could decrease cyclin-dependent kinase (CDK)NIB/p27 (a CDK inhibitor) by repressing ubiquitin specific peptidase 37 (USP37), which could form a complex with p27 to promote its deubiquitination and stabilization, and resulting in blocked cell proliferation [ xref ]."
27153061
USP37 deubiquitinates CDKN1B.
1 | 2
USP37 leads to the deubiquitination of CDKN1B. 2 / 2
1 | 1
reach
"Constitutive expression of USP37 promotes p27 deubiquitination in medulloblastoma cells, whereas a catalytically dead USP37 mutant is unable to stabilize p27.Dobson et al. further explored the molecular basis of REST-induced USP37 downregulation and found that USP37 supresses medulloblastoma tumor growth in an orthotopic mouse model by modulating its downstream targets [87]."
| PMC
ubibrowser
"Ectopically expressed wild-type USP37 formed a complex with p27, promoted its deubiquitination and stabilization and blocked cell proliferation."
22665064
Modified USP37 leads to the deubiquitination of CDKN1B. 1 / 1
| 1
reach
"Constitutive USP37 expression promotes p27 deubiquitination."
22665064
USP37 ubiquitinates CDKN1B.
| 1 1
USP37 ubiquitinates CDKN1B. 2 / 2
| 1 1
reach
"To confirm that USP37 ubiquitinated p27, we performed in vitro DUB assays using purified epitope tagged proteins from transiently transfected 293T cells."
22665064
sparser
"To confirm that USP37 ubiquitinated p27, we performed in vitro DUB assays using purified epitope tagged proteins from transiently transfected 293T cells."
22665064
USP37 activates CDKN1B.
| 2
USP37 activates CDKN1B. 2 / 2
| 2
reach
"Addition of USP37 to a reaction mix containing HA-ubiquitin and Myc-p27 caused a substantial increase in the 27kD form of p27 and a corresponding decrease in the slower migrating forms of the protein relative to reactions containing USP37 and a protease inhibitor N-ethyl maleimide (NEM) or USP37 C350-S or USP1 (XREF_FIG)."
22665064
reach
"Since concomitant loss of REST and USP37 expression attenuated p27 stabilization and differentiation and rescued cell proliferation, our data strongly suggest that repression of USP37 and consequent p27 degradation, are important for REST dependent maintenance of cell proliferation."
22665064
USP37 inhibits CDKN1B.
| 1
USP37 inhibits CDKN1B. 1 / 1
| 1
reach
"Knockdown of REST and USP37 prevented p27 stabilization and blocked the diminution in proliferative potential that normally accompanied REST loss."
22665064
BLM affects USP37
| 11 2
BLM binds USP37.
| 8 2
BLM binds USP37. 10 / 10
| 8 2
reach
"Here, we demonstrate that the deubiquitinating enzyme USP37 interacts with BLM and that USP37 deubiquitinates and stabilizes BLM, thereby sustaining the DNA damage response (DDR)."
34606619
reach
"We found that only HA-tagged USP37 bound with endogenous BLM (Figure 1A)."
34606619
reach
"In addition, we examined the endogenous interaction between USP37 and BLM in HEK293T cells and confirmed that USP37 interacted with BLM (Figure 1C, D)."
34606619
reach
"Mechanistically, USP37 is phosphorylated by ATM following DNA damage, which increases the binding between USP37 and BLM and leads to BLM deubiquitylation."
34606619
sparser
"Collectively, our results establish a novel molecular mechanism for the USP37-BLM axis in regulating DSB repair with an important role in chemotherapy and radiotherapy response in human cancers."
34606619
reach
"Mechanistically, DNA double-strand breaks (DSB) promotes ATM phosphorylation of USP37 and enhances the binding between USP37 and BLM."
34606619
reach
"Collectively, these results indicate that DNA damage can strengthen the interaction between USP37 and BLM, which in turn stabilizes BLM."
34606619
reach
"We found that S114A mutation attenuated the interaction between USP37 and BLM (Figure 5E)."
34606619
reach
"To support this notion, we found that the interaction between USP37 and BLM was enhanced upon cisplatin treatment in cells (Figure 4D)."
34606619
sparser
"Here, we demonstrate that the deubiquitinating enzyme USP37 interacts with BLM and that USP37 deubiquitinates and stabilizes BLM, thereby sustaining the DNA damage response (DDR)."
34606619
BLM activates USP37.
| 3
BLM activates USP37. 3 / 3
| 3
reach
"Furthermore, we found that overexpression of BLM rescued DSB end resection in USP37 depletion cells (Supplementary Figure S4I, J)."
34606619
reach
"In addition, over-expression of BLM rescued DSB end resection in USP37 depletion cells (Supplementary Figure S4I, J)."
34606619
reach
"Moreover, we found that overexpressed BLM restored the cells resistance to cisplatin or IR in the USP37 knockdown cells reconstituted with USP37-C350A mutant (Supplementary Figure S6H–J)."
34606619
MiR-320b affects USP37
| 12
MiR-320b activates USP37.
| 5
MiR-320b activates USP37. 5 / 5
| 5
reach
"Taken together, our study suggested that miR-320b suppressed CDT1 by targeting USP37 to inhibit the progression of lung cancer."
33898105
reach
"The results revealed that 6IH treatment could decrease the expression of miR-320b yet increase that of USP37 and CDT1, and the overexpression of miR-320b could downregulate the expressions of USP37 and CDT1, while the effect of miR-320b mimic on the expressions of miR-320b, USP37, and CDT1 could be counteracted by overexpressed CDT1 (oe-CDT1)."
33898105
reach
"MiR-320b inhibits IH mediated lung cancer progression by targeting USP37."
33898105
reach
"Taken together, our data suggested that miR-320b inhibited IH mediated lung cancer progression by targeting USP37."
33898105
reach
"These findings have confirmed that miR-320b inhibits IH mediated lung cancer progression by targeting USP37."
33898105
MiR-320b inhibits USP37.
| 4
MiR-320b inhibits USP37. 4 / 4
| 4
reach
"We have also proven that miR-320b inhibited lung cancer tumorigenesis and progression by regulating USP37 and CDT1 axis, by using invivo models of human lung cancer xenograft."
33898105
reach
"However, co-transfecting miR-320b mimic and USP37 failed to inhibit IH induced lung cancer cell invasion (XREF_FIG D and XREF_SUPPLEMENTARY B), indicating that miR-320b inhibited 6IH induced invasion in a USP37 dependent manner."
33898105
reach
"Finally, the findings of our study concluded that miR-320b inhibited the tumorigenesis and progression of lung cancer by regulating the USP37 and CDT1 axis (XREF_FIG)."
33898105
reach
"Overexpression of miR-320b downregulates USP37 in an in vivo xenograft model, resulting in repression of the CDT1 inhibition of LC progression."
| PMC
MiR-320b decreases the amount of USP37.
| 3
MiR-320b decreases the amount of USP37. 3 / 3
| 3
reach
"The overexpression of miR-320b significantly reduced the protein level of USP37 while inhibiting miR-320b resulted in an increased expression of USP37 (XREF_FIG H and 3I)."
33898105
reach
"We found that the expression of miR-320b was decreased while that of USP37 and CDT1 were increased in mice bearing IH treated cells, and miR-320b agmoir significantly increased the expression of miR-320b and reduced the expressions of USP37 and CDT1."
33898105
reach
"The results revealed that 6IH treatment could decrease the expression of miR-320b yet increase that of USP37 and CDT1, and the overexpression of miR-320b could downregulate the expressions of USP37 and CDT1, while the effect of miR-320b mimic on the expressions of miR-320b, USP37, and CDT1 could be counteracted by overexpressed CDT1 (oe-CDT1)."
33898105
Snail1 affects USP37
| 12
USP37 binds Snail1. 10 / 12
| 12
reach
"To explore whether the interaction between Snail1 and USP37 requires Snail1 phosphorylation, we utilized CIP to remove phosphate groups from the substrate proteins."
33391500
reach
"We further investigated the interaction between USP37 and Snail1."
33391500
reach
"Since GSK-3beta is the major kinase involved in Snail1 phosphorylation in the SRD region, the GSK-3beta inhibitor LiCl was used to assess GSK-3beta inhibition in the interaction of USP37 and Snail1."
33391500
reach
"As shown in Figure XREF_FIG B, LiCl treatment also significantly disrupted the USP37 and Snail1 interaction."
33391500
reach
"Co-IP results showed that GSK-3beta siRNAs diminished approximately 60% of the interaction of USP37 and Snail1."
33391500
reach
"We also determined that USP37 interacts with and deubiquitinates Snail1 directly, which is transcriptionally activated by PLAGL2."
33391500
reach
"Therefore, the SRD domain is also crucial for USP37 mediated Snail1 deubiquitination and the interaction between USP37 and Snail1."
33391500
reach
"Overall, these results demonstrate that USP37 interacts with and deubiquitinates Snail1 directly."
33391500
reach
"Strikingly, Co-IP experiments showed that the interaction between USP37 and Snail1 was strongly impeded by CIP intervention."
33391500
reach
"However, in cells with high expression of USP37, phosphorylated Snail1 promotes the mutual binding of USP37 and Snail1, and the ability of USP37 to bind to phosphorylated Snail1 is significantly enhanced."
33391500
REST affects USP37
| 10 1
REST increases the amount of USP37.
| 3
REST increases the amount of USP37. 3 / 3
| 3
reach
"Regulation of USP37 Expression by REST associated G9a dependent Histone Methylation."
28483947
reach
"Notably, Das et al. reported that REST induces medulloblastoma oncogenesis by repressing USP37 transcription, thereby leading to low levels of the p27 tumor suppressor, which controls proliferation and cell cycle exit by inhibiting CDK1 in cerebellar progenitor cells."
| PMC
reach
"Like p27, a reciprocal association between USP37 and REST is present, and REST KD increases USP37 mRNA levels."
| PMC
REST decreases the amount of USP37.
| 3
REST decreases the amount of USP37. 3 / 3
| 3
reach
"REST also represses the transcription of the anti-proliferative deubiquitylase USP37, and drugs that reactivate USP37 expression may have therapeutic applications [XREF_BIBR]."
25768332
reach
"Previously, we observed that the expression of USP37 is transcriptionally repressed by the RE1 Silencing Transcription Factor (REST), which requires chromatin remodeling factors for its activity."
28483947
reach
"Conversely, REST knockdown upregulated USP37 gene expression and promoted an increase in p27 protein levels."
22665064
REST binds USP37.
| 1 1
USP37 binds REST. 2 / 3
| 1 1
sparser
"However, the association of USP37 with REST needs further investigation."
32720471
reach
"Like p27, a reciprocal association between USP37 and REST is present, and REST KD increases USP37 mRNA levels."
| PMC
REST activates USP37.
| 2
REST activates USP37. 2 / 2
| 2
reach
"Constitutive expression of USP37 promotes p27 deubiquitination in medulloblastoma cells, whereas a catalytically dead USP37 mutant is unable to stabilize p27.Dobson et al. further explored the molecular basis of REST-induced USP37 downregulation and found that USP37 supresses medulloblastoma tumor growth in an orthotopic mouse model by modulating its downstream targets [87]."
| PMC
reach
"In medulloblastomas, REST expression could decrease cyclin dependent kinase (CDK) NIB and p27 (a CDK inhibitor) by repressing ubiquitin specific peptidase 37 (USP37), which could form a complex with p27 to promote its deubiquitination and stabilization, and resulting in blocked cell proliferation [XREF_BIBR]."
27153061
REST methylates USP37.
| 1
REST leads to the methylation of USP37. 1 / 1
| 1
reach
"REST globally increases G9a-dependent histone H3K9 mono-, di- and trimethylation of the USP37 promoter, leading to downregulated USP37 mRNA."
| PMC
PLAGL2 affects USP37
| 10 2
PLAGL2 increases the amount of USP37.
| 6
PLAGL2 increases the amount of USP37. 6 / 6
| 6
reach
"Besides, we showed that PLAGL2 directly activates USP37 expression, which targets Snail1 to proteasome ubiquitination degradation."
33391500
reach
"Finally, PLAGL2 modulates SNAI1 stability by activating USP37 transcription."
| PMC
reach
"These results collectively suggest that PLAGL2 transcriptionally activates USP37 expression to increase Snail1 protein levels, which in turn mediates the proliferation, migration, and invasion of GC cells."
33391500
reach
"PLAGL2 activated the transcription of deubiquitinase USP37, which then interacted with and deubiquitinated Snail1 protein directly."
33391500
reach
"Moreover, silencing PLAGL2 decreased the mRNA level of USP37 in SGC7901 cells, whereas PLAGL2 overexpression increased the USP37 mRNA level in AGS cells."
33391500
reach
"PLAGL2 modulates Snail1 stability by activating USP37 transcription."
33391500
PLAGL2 binds USP37.
| 2 1
USP37 binds PLAGL2. 3 / 3
| 2 1
reach
"The ChIP assay revealed that PLAGL2 was bound to the USP37 promoter region."
33391500
reach
"PLAGL2 specifically binds to the GRGGC(N)6-8RGGK consensus sequences in the USP37 promoter region and activates its transcription, subsequently stabilizing SNAI1 and promoting EMT in GC cells [64]."
| PMC
sparser
"The ChIP assay revealed that PLAGL2 was bound to the USP37 promoter region (Figure xref C)."
33391500
PLAGL2 deubiquitinates USP37.
| 1
PLAGL2 leads to the deubiquitination of USP37. 1 / 1
| 1
reach
"PLAGL2 activated the transcription of deubiquitinase USP37, which then interacted with and deubiquitinated Snail1 protein directly."
33391500
PLAGL2 decreases the amount of USP37.
| 1
Modified PLAGL2 decreases the amount of USP37. 1 / 1
| 1
reach
"Moreover, silencing PLAGL2 decreased the mRNA level of USP37 in SGC7901 cells, whereas PLAGL2 overexpression increased the USP37 mRNA level in AGS cells."
33391500
PLAGL2 activates USP37.
| 1
PLAGL2 activates USP37. 1 / 1
| 1
sparser
"Although PLAGL2 does not function as a deubiquitinase to impede Snail1 ubiquitination, PLAGL2 transcriptionally activates USP37, which finally interacts with and deubiquitinates Snail1 directly."
33391500
MYC affects USP37
4 | 1 1 5
USP37 binds MYC. 10 / 11
4 | 1 1 4
biogrid
No evidence text available
25284584
biogrid
No evidence text available
25284584
sparser
"Given the structural properties of the interaction sites in the c-MYC-USP37 complex, a peptidyl inhibitor has been designed."
36985413
sparser
"Interestingly, unlike USP28 [ xref ], USP37 directly binds to c-Myc and acts independently of Fbw37."
34201062
reach
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity dependent manner."
25284584
trips
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity-dependent manner."
25284584
sparser
"Further studies indicate that USP37 directly interacts with c-Myc and deubiquitinates c-Myc in a DUB activity-dependent manner."
25284584
biogrid
No evidence text available
25284584
biogrid
No evidence text available
25284584
sparser
"Investigating In Situ Expression of c-MYC and Candidate Ubiquitin-Specific Proteases in DLBCL and Assessment for Peptidyl Disruptor Molecule against c-MYC-USP37 Complex."
36985413
USP37 binds MYC, Hemagglutinins, and 14-3-3γ. 1 / 1
| 1
sparser
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3γ and Myc-USP37."
26427597
USP37 affects GLI1
| 9 2
USP37 binds GLI1.
| 4 2
USP37 binds GLI1. 6 / 6
| 4 2
sparser
"MG132, CHX chase, immunofluorescence staining and co-immunoprecipitation assays were used to test the interaction between USP37 and Gli-1."
30482232
reach
"MG132, CHX chase, immunofluorescence staining and co-immunoprecipitation assays were used to test the interaction between USP37 and Gli-1."
30482232
reach
"USP37 also interacted with and stabilized glioma-associated oncogene 1 (Gli-1) protein."
30482232
reach
"Further studies detected that USP37 also interacted with and stabilized Gli-1 protein, which is the main activator of Hedgehog target gene."
30482232
reach
"USP37 interacts with and stabilizes Gli-1 protein."
30482232
sparser
"Co-IP assay indicated that USP37 interacted with Gli-1(Fig. xref )."
30482232
USP37 activates GLI1.
| 3
USP37 activates GLI1. 3 / 3
| 3
reach
"We found that lower expression level of USP37 obviously impaired the expression of Hh targets (Smo and Gli-1) and cell proliferation marker Ki-67 in the tumor tissues as seen by immunohistochemical staining (Fig. 8e)."
30482232
reach
"Furthermore, knockdown of USP37 expression significantly decreased the stability of Gli-1 protein both in MCF-7 and MDA-MB-231 cells (Fig. 7d and e)."
30482232
reach
"Knockdown of USP37 significantly decreased hedgehog (Hh) pathway components Smo and Gli-1."
30482232
USP37 increases the amount of GLI1.
| 1
USP37 increases the amount of GLI1. 1 / 1
| 1
reach
"Upregulation of USP37 could enhance protein expression levels of Smo and Gli-1."
30482232
USP37 deubiquitinates GLI1.
| 1
Modified USP37 leads to the deubiquitination of GLI1. 1 / 1
| 1
reach
"Moreover, overexpression of USP37 in breast cancer promoted stemness, cell invasion, and chemoresistance by deubiquitinating the glioma associated oncogene 1 protein XREF_BIBR."
33391500
USP37 affects cisplatin
| 2 8
USP37 inhibits cisplatin.
| 2 4
USP37 inhibits cisplatin. 6 / 6
| 2 4
reach
"Additionally, USP37 knockdown enhanced the sensitivity of breast cancer cells to cisplatin in vitro and in vivo."
30482232
eidos
"Additionally , USP37 knockdown enhanced the sensitivity of breast cancer cells to cisplatin in vitro and in vivo ."
30482232
reach
"Additionally, USP37 knockdown inhibited tumorigenicity and increased anticancer effect of cisplatin in vivo."
30482232
reach
"USP37 can regulate the stemness, cell invasion and EMT via Hh pathway, and decreased USP37 confers sensitivity to cisplatin in breast cancer cells."
30482232
reach
"USP37 knockdown inhibits tumorigenicity and increases sensitivity to cisplatin in vivo."
30482232
eidos
"These results indicated that USP37 downregulation attenuates breast cancer progression and enhances sensitivity to cisplatin in vivo ."
30482232
USP37 activates cisplatin.
| 4
USP37 activates cisplatin. 4 / 4
| 4
reach
"Finally, we demonstrated that high level of USP37 mediated cisplatin or IR resistance in breast cancer in a BLM-dependent manner and clarified the role of USP37 as a potential therapeutic target in breast cancer."
34606619
reach
"Additionally, USP37 knockdown inhibited tumorigenicity and increased anticancer effect of cisplatin in vivo."
30482232
reach
"USP37 overexpression also increased the formation of spheroid and chemo-resistance to cisplatin-induced growth inhibition (Fig. 5b, d)."
30482232
reach
"These results indicated that USP37 downregulation attenuates breast cancer progression and enhances sensitivity to cisplatin in vivo."
30482232
USP37 affects Cyclin
| 10
USP37 deubiquitinates Cyclin.
| 5
USP37 deubiquitinates Cyclin. 4 / 4
| 4
reach
"USP37 deubiquitinates and stabilizes Cyclin A and promotes S phase entry."
33643919
reach
"Usp37 binds APC/C Cdh1 in G1 and deubiquitinates the APC/C substrate cyclin A [XREF_BIBR]."
21978762
reach
"Deubiquitination and stabilization of the APC/C substrate cyclin A by USP37 enables entry into S phase."
21596315
reach
"These results argue that USP37 deubiquitinates cyclin A directly as opposed to being an EMI1-type APC/C inhibitor."
21596315
USP37 deubiquitinates Cyclin on T293. 1 / 1
| 1
reach
"We investigated deubiquitination of cyclin A by USP37 in 293T cells cotransfected with Myc-cyclin A, HA-ubiquitin, and either USP37 or USP37DD."
21596315
USP37 activates Cyclin.
| 4
Mutated USP37 activates Cyclin. 2 / 2
| 2
reach
"USP37-FLAG, but not catalytic mutant USP37 C 350 S (hereafter called USP37DD for DUB-Dead), also increased endogenous cyclin A."
21596315
reach
"Reconstitution of an shRNA resistant KEN box-3 mutant USP37 in USP37-knockdown U2OS cells enables cyclin A to be accumulated again."
21596315
USP37 activates Cyclin. 2 / 2
| 2
reach
"In this regard, cyclin A2 degradation during interphase is specifically impeded by the deubiquitinating enzyme USP37 54, but this enzyme does not appear to antagonize cyclin B1 degradation."
22286100
reach
"USP37 was shown to induce the stability of cyclin A by deubiquitination, resulting in an accumulation of cyclin A, which leads to the G1-S phase transition [XREF_BIBR]."
26427597
USP37 inhibits Cyclin.
| 1
USP37 inhibits ubiquitinated Cyclin. 1 / 1
| 1
reach
"Western blot analysis of cyclin A following immunoprecipitation of HA-ubiquitin-modified proteins from SDS and heat denatured lysates revealed that USP37, but not USP37DD, reduced the amount of ubiqui[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
USP37 affects BRCA1
1 | 9
USP37 inhibits BRCA1.
| 5
USP37 inhibits BRCA1. 5 / 5
| 5
reach
"USP26 and USP37 limit the ubiquitin-dependent sequestration of BRCA1 and facilitate BRCA1-PALB2-BRCA2-RAD51 association at damaged chromatin to promote HR repair [77]."
33797206
reach
"USP26 and USP37 have additionally been shown to impair accumulation of RAP80 and BRCA1 [154]."
32708614
reach
"We reasoned that USP26 and USP37 may antagonize the RAP80 dependent sequestration of BRCA1 by removing RNF8 and RNF168 mediated ubiquitylation and thereby promote HR."
26101254
reach
"In agreement with this hypothesis, we found that USP26 or USP37 depletion inhibits the efficient association of BRCA1 with PALB2, a unique subunit of the BRCC complex."
26101254
reach
"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."
26101254
USP37 activates BRCA1.
| 4
USP37 activates BRCA1. 4 / 4
| 4
reach
"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."
26101254
reach
"In relation to its role maintaining chromosomal integrity, USP37 localizes to double-strand breaks and promotes BRCA1 inclusion into complexes responsible for homologous recombination 16."
30858488
reach
"On the other hand, we also found that USP26 and USP37 promote the efficient association of BRCA1 with PALB2."
26101254
reach
"Loss of USP26 or USP37 impairs HR by counteracting RAP80 dependent sequestration of BRCA1."
26101254
USP37 binds BRCA1.
1 |
BRCA1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
E2F1 affects USP37
7 | 3
E2F1 decreases the amount of USP37.
7 |
E2F1 decreases the amount of USP37. 7 / 7
7 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
E2F1 increases the amount of USP37.
| 2
E2F1 increases the amount of USP37. 1 / 1
| 1
reach
"Not surprisingly, transactivation mutant of E2F1, E2F1 1-374 (DeltaC) is unable to stimulate the expression of USP37 gene."
25347529
Mutated E2F1 increases the amount of USP37. 1 / 1
| 1
reach
"Not surprisingly, transactivation mutant of E2F1, E2F1 1-374 (DeltaC) is unable to stimulate the expression of USP37 gene."
25347529
E2F1 activates USP37.
| 1
E2F1 activates USP37. 1 / 1
| 1
reach
"In addition, E2F1 overexpression in U2OS cells increased both USP37 mRNA and USP37 protein."
21596315
YWHAG affects USP37
3 1 |
YWHAG binds USP37. 4 / 9
3 1 |
biogrid
No evidence text available
26427597
biogrid
No evidence text available
26427597
biogrid
No evidence text available
26427597
hprd
No evidence text available
15324660
USP37 affects Ubiquitin
| 2 7
USP37 binds Ubiquitin.
| 7
sparser
"Detecting endogenous ubiquitin-protein conjugates that coimmunoprecipitate with transfected wild-type and UIM mutant USP37 proteins suggested only UIM2 and UIM3, rather than UIM1, permit the interaction between USP37 and ubiquitin-protein conjugates in a synergistic manner."
| PMC
sparser
"To determine whether the physical association between USP37 and WAPL is dependent on the ubiquitin-binding activity of USP37, the same mutations were introduced into full-length FLAG-USP37 and express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
sparser
"Because USP37 stabilizes chromatin-associated WAPL and the ubiquitin-binding activities of USP37 are important for its association with WAPL, we next aimed to determine whether USP37 regulates deubiqu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
sparser
"In the case of K48-linked substrates, binding of the UIMs to the proximal Ub increased catalytic efficiency of USP37 largely through k cat and to a lesser degree through K M . This result was somewhat counter-intuitive since we expected that binding of the UIMs of USP37 to Ub to have a more pronounced effect on K M (a proxy for binding affinity) since others have shown that UIM mutations perturbed the ability to pull down Ub conjugates xref ."
30858488
sparser
"The issue of how the binding of the UIMs of USP37 to the proximal Ub of K48 di-Ub enhances activity remains an open question."
30858488
sparser
"We expected that, if USP37 deubiquitylates WAPL, the ubiquitin-binding activities of USP37 would be critical for the interaction between USP37 and WAPL."
26299517
sparser
"One possibility is that phosphorylation enhances USP37 binding to its ubiquitinated substrates by altering the configuration of its three ubiquitin-interacting motifs (UIMs) spanning Ser 704 -Ser 723 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
USP37 inhibits Ubiquitin.
| 2
USP37 inhibits Ubiquitin. 2 / 2
| 2
reach
"USP26 or USP37 antagonize ubiquitin dependent spreading of RAP80-BRCA1."
26101254
reach
"Previous studies reported that USP37 increased the Warburg effect and cell viability by repressing ubiquitin mediated degradation of c-Myc XREF_BIBR."
33391500
USP37 affects Cohesin
| 3 5
USP37 binds Cohesin.
| 2 5
Cohesin binds USP37. 5 / 6
| 2 3
reach
"Given the mitotic delay and chromosome segregation errors we observed in USP37 depleted cells and that our study and others have implicated cohesion factors in regulating these processes [17, 18], we [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
sparser
"Indeed, cohesin subunits MYC-SMC1, MYC-SCC1, MYC-SA2, and GFP-SMC3 co-immunoprecipitate with FLAG-USP37 in HEK293 cells ( Figure 2 C), confirming that USP37 associates with cohesin."
26299517
sparser
"USP37 associates with cohesin and contributes to sister chromatid resolution."
26299517
sparser
"This discrepancy may be due to cell type–specific or technical differences, since the reported interaction between USP37 and cohesin required ectopic expression of at least one component of the putative complex."
33334891
reach
"This discrepancy may be due to cell type specific or technical differences, since the reported interaction between USP37 and cohesin required ectopic expression of at least one component of the putative complex."
33334891
Cohesin binds USP37 and WAPL. 1 / 1
| 1
sparser
"The authors further demonstrated that USP37 interacts with both cohesin and a negative regulator WAPL, which is required for releasing cohesin from chromatid arms in prophase."
32201366
Cohesin binds SMC1, USP37, and SMC3. 1 / 1
| 1
sparser
"Identifying USP37-interacting partners with proximity-dependent biotin identification (BioID) found that USP37 interacts with the cohesin complex proteins SMC3, SMC1, SSCC1, and SA1/2, as well with the regulators of cohesion WAPL and NIPBL [ xref ]."
| PMC
USP37 activates Cohesin.
| 1
USP37 activates Cohesin. 1 / 1
| 1
reach
"Given the critical role of WAPL in the prophase pathway, it will be interesting to discern whether USP37 contributes to other WAPL dependent processes, such as chromatin structure or protecting cohesi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
ATM affects USP37
| 8 1
ATM phosphorylates USP37. 7 / 7
| 6 1
reach
"Together, these data suggest that USP37 phosphorylation by ATM is important for its regulation of DDR."
34606619
reach
"Interestingly, WT USP37 was phosphorylated by ATM, which in turn increased its deubiquitination activity towards BLM, while the S114A mutant did not have this effect."
34606619
reach
"Mechanistically, USP37 is phosphorylated by ATM following DNA damage, which increases the binding between USP37 and BLM and leads to BLM deubiquitylation."
34606619
reach
"Mechanistically, DNA damage activates ATM which phosphorylates USP37 and activates its deubiquitinase activity to stabilize BLM."
34606619
reach
"Mechanistically, DNA double-strand breaks (DSB) promotes ATM phosphorylation of USP37 and enhances the binding between USP37 and BLM."
34606619
reach
"These results confirm that ATM phosphorylates USP37 following DNA damage."
34606619
sparser
"Mechanistically, DNA double-strand breaks (DSB) promotes ATM phosphorylation of USP37 and enhances the binding between USP37 and BLM."
34606619
ATM phosphorylates USP37 on S114. 2 / 2
| 2
reach
"Collectively, these data suggest that S114 phosphorylation enhances the interaction between UPS37 and BLM and S114 phosphorylation of USP37 by ATM is important for USP37 deubiquitinating BLM following DNA damage."
34606619
reach
"We further confirmed that mutation of S114 (S114A) abrogated the phosphorylation following cisplatin treatment (Figure 5D), suggesting that USP37 is phosphorylated at S114 by ATM following DNA damage."
34606619
Ubiquitin affects USP37
| 1 7
Ubiquitin binds USP37.
| 7
sparser
"Detecting endogenous ubiquitin-protein conjugates that coimmunoprecipitate with transfected wild-type and UIM mutant USP37 proteins suggested only UIM2 and UIM3, rather than UIM1, permit the interaction between USP37 and ubiquitin-protein conjugates in a synergistic manner."
| PMC
sparser
"To determine whether the physical association between USP37 and WAPL is dependent on the ubiquitin-binding activity of USP37, the same mutations were introduced into full-length FLAG-USP37 and express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
sparser
"Because USP37 stabilizes chromatin-associated WAPL and the ubiquitin-binding activities of USP37 are important for its association with WAPL, we next aimed to determine whether USP37 regulates deubiqu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
sparser
"In the case of K48-linked substrates, binding of the UIMs to the proximal Ub increased catalytic efficiency of USP37 largely through k cat and to a lesser degree through K M . This result was somewhat counter-intuitive since we expected that binding of the UIMs of USP37 to Ub to have a more pronounced effect on K M (a proxy for binding affinity) since others have shown that UIM mutations perturbed the ability to pull down Ub conjugates xref ."
30858488
sparser
"The issue of how the binding of the UIMs of USP37 to the proximal Ub of K48 di-Ub enhances activity remains an open question."
30858488
sparser
"We expected that, if USP37 deubiquitylates WAPL, the ubiquitin-binding activities of USP37 would be critical for the interaction between USP37 and WAPL."
26299517
sparser
"One possibility is that phosphorylation enhances USP37 binding to its ubiquitinated substrates by altering the configuration of its three ubiquitin-interacting motifs (UIMs) spanning Ser 704 -Ser 723 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
Ubiquitin activates USP37.
| 1
Ubiquitin activates USP37. 1 / 1
| 1
reach
"Since, USP37 is targeted by both these ubiquitin ligases and HBx chaperoned USP37 out of the nucleus, we wondered if it was safeguard mechanism to prevent the ubiquitination and degradation of USP37."
25347529
reach
"Given that USP26 and USP37 are able to reverse RNF8/168 mediated ubiquitylation and promote HR, these enzymes would be ideal candidates to facilitate the repositioning of ubiquitylated substrates away from the DSB."
26101254
reach
"Interestingly, in contrast with initial findings assessing overexpression of these DUBs, knockdown of either USP26 or USP37 impairs accumulation of key HR factors including RAD51 as well as PALB2, CtIP, and RPA [154]."
32708614
reach
"A striking conclusion from our study is that both over-expression as well as knockdown of USP26 or USP37 impairs HR."
26101254
reach
"Loss of USP26 and USP37 function markedly impairs the assembly of PALB2, RAD51 and efficient HR."
26101254
reach
"Loss of USP26 or USP37 impairs HR by counteracting RAP80 dependent sequestration of BRCA1."
26101254
USP37 inhibits homologous recombination. 2 / 2
| 2
reach
"We reasoned that USP26 and USP37 may antagonize the RAP80 dependent sequestration of BRCA1 by removing RNF8 and RNF168 mediated ubiquitylation and thereby promote HR."
26101254
reach
"Depletion of USP26 or USP37 disrupts the execution of HR and this effect is alleviated by the simultaneous depletion of RAP80."
26101254
USP37 increases the amount of homologous recombination.
| 1
USP37 increases the amount of homologous recombination. 1 / 1
| 1
reach
"Moreover, co-depletion of either USP26 or USP37 and RAP80 was able to restore levels of HR."
32708614
USP37 affects ZBTB16
1 | 5 1
USP37 binds ZBTB16.
| 2 1
ZBTB16 binds USP37. 3 / 4
| 2 1
reach
"We showed that USP37 interacted with PLZF and RARA through the PLZF moiety and sustained PLZF and RARA steady state levels."
23208507
reach
"In contrast, the deubiquitinating enzyme USP37 interacts with Plzf which increases Plzf protein stability [XREF_BIBR]."
24359566
sparser
"In contrast, the deubiquitinating enzyme USP37 interacts with Plzf which increases Plzf protein stability [ xref ]."
24359566
USP37 activates ZBTB16.
| 3
USP37 activates ZBTB16. 3 / 3
| 3
reach
"It was reported that USP37 induced the stability of the oncogenic fusion protein PLZF and RARA."
26427597
reach
"Subsequently, it was verified that USP37 expression modulated the oncogenic fusion protein PLZF/RARA stability and cell transformation potential in PLZF/RARA-associated acute promyelocytic leukemia [33]."
30482232
reach
"Furthermore, overexpression or depletion of USP37 caused an increase or decrease of PLZF and RARA protein half-life, correlating with down- or upregulation of PLZF and RARA poly-ubiquitination, respectively."
23208507
USP37 deubiquitinates ZBTB16.
1 |
USP37 deubiquitinates ZBTB16. 1 / 1
1 |
ubibrowser
"The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability."
23208507
USP37 affects HBx
| 7 1
USP37 binds HBx. 8 / 8
| 7 1
reach
"Our co-immunoprecipitation and confocal microscopic studies suggested a direct interaction between USP37 and HBx."
25347529
reach
"Further, we observed that HBx interacted with USP37 and chaperoned it out of nucleus to prevent its ubiquitination and degradation by E3 ubiquitin ligases."
25347529
reach
"Since, HBx and USP37 co-localized in cells, we next examined the possibility of a physical interaction between HBx and USP37."
25347529
reach
"Venturing further we explored the possibility of a physical interaction between HBx and USP37."
25347529
sparser
"Our co-immunoprecipitation and confocal microscopic studies suggested a direct interaction between USP37 and HBx."
25347529
reach
"The dichotomy in the action of two E3 ligases targeting USP37 further inspired us to investigate the possibility of direct or indirect interaction between HBx and USP37 which could reveal a bigger role of HBx in protection of USP37."
25347529
reach
"HBx interacts with USP37 and translocates it to cytoplasm."
25347529
reach
"This study has relied on the cell culture based system where HBx was co-expressed along with USP37-DD or USP37 either in immortalized human hepatocytes or in hepatoma Huh7 cells to elucidate the oncogenic cooperation between HBx and USP37."
25347529
USP37 affects APC_C
| 6 2
USP37 binds APC_C.
| 4 2
APC_C binds USP37. 4 / 4
| 4
reach
"Knockdown of CDH1 markedly reduced the interaction between USP37 and CDC27, suggesting that core APC/C components bind USP37 indirectly through CDH1."
21596315
reach
"EMI1 was not detected in the USP37 and APC/C complex (data not shown) and, similarly, USP37 was not present in the EMI1 and APC/C complex (M.K.S. and P.K.J., unpublished data)."
21596315
reach
"The core components of APC bind with USP37 through CDH1."
| PMC
reach
"Ubiquitin specific protease (USP) 44 has been described in checkpoint responsive regulation of the APC/C by stabilizing the APC-inhibitory MAD2 and CDC20 complex (Joo et al., 2007; Stegmeier et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
APC_C binds CDH1 and USP37. 1 / 1
| 1
sparser
"The core components of APC bind with USP37 through CDH1."
| PMC
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
USP37 inhibits APC_C.
| 1
USP37 inhibits APC_C. 1 / 1
| 1
reach
"Thus, Usp44 and Usp37 can restrict the activity of the major K11 specific ligase, the APC/C, in addition to deubiquitinating substrates modified with K11 linked chains."
21978762
USP37 activates APC_C.
| 1
USP37 activates APC_C. 1 / 1
| 1
reach
"Moreover, USP37 contributes to the stabilization of cyclin A by counteracting APC/Cdh1 functioning."
30241373
USP37 affects 14-3-3gamma
| 8
USP37 binds 14-3-3gamma.
| 3
USP37 binds 14-3-3gamma. 3 / 3
| 3
reach
"The results showed that of these six isoforms, only 14-3-3gamma bound to USP37, demonstrating that 14-3-3gamma is a unique binding partner of USP37."
26427597
reach
"Reciprocal co-IP confirmed that these two proteins interacted with each other, with USP37 strongly binding to 14-3-3gamma."
26427597
reach
"To determine the functional significance of the interaction between USP37 and 14-3-3gamma, we assessed whether the polyubiquitination of 14-3-3gamma was deubiquitinated by USP37."
26427597
USP37 increases the amount of 14-3-3gamma.
| 2
USP37 increases the amount of 14-3-3gamma. 2 / 2
| 2
reach
"USP37 also increased the endogenous level of 14-3-3gamma in a dose dependent manner, as shown by the exogenous level."
26427597
reach
"USP37 dramatically increased the protein expression level of 14-3-3gamma in a dose dependent manner."
26427597
USP37 deubiquitinates 14-3-3gamma.
| 1
USP37 deubiquitinates 14-3-3gamma. 1 / 1
| 1
reach
"To determine the functional significance of the interaction between USP37 and 14-3-3gamma, we assessed whether the polyubiquitination of 14-3-3gamma was deubiquitinated by USP37."
26427597
USP37 decreases the amount of 14-3-3gamma.
| 1
USP37 decreases the amount of 14-3-3gamma. 1 / 1
| 1
reach
"As expected, the ubiquitination level of 14-3-3gamma was decreased by the catalytic activity of Myc-USP37."
26427597
USP37 activates 14-3-3gamma.
| 1
USP37 activates 14-3-3gamma. 1 / 1
| 1
reach
"These findings indicate that USP37 participates in the regulation of cell proliferation, and that USP37 induces stability of 14-3-3gamma."
26427597
HBx affects USP37
| 7 1
USP37 binds HBx. 8 / 8
| 7 1
reach
"Our co-immunoprecipitation and confocal microscopic studies suggested a direct interaction between USP37 and HBx."
25347529
reach
"Further, we observed that HBx interacted with USP37 and chaperoned it out of nucleus to prevent its ubiquitination and degradation by E3 ubiquitin ligases."
25347529
reach
"Since, HBx and USP37 co-localized in cells, we next examined the possibility of a physical interaction between HBx and USP37."
25347529
reach
"Venturing further we explored the possibility of a physical interaction between HBx and USP37."
25347529
sparser
"Our co-immunoprecipitation and confocal microscopic studies suggested a direct interaction between USP37 and HBx."
25347529
reach
"The dichotomy in the action of two E3 ligases targeting USP37 further inspired us to investigate the possibility of direct or indirect interaction between HBx and USP37 which could reveal a bigger role of HBx in protection of USP37."
25347529
reach
"HBx interacts with USP37 and translocates it to cytoplasm."
25347529
reach
"This study has relied on the cell culture based system where HBx was co-expressed along with USP37-DD or USP37 either in immortalized human hepatocytes or in hepatoma Huh7 cells to elucidate the oncogenic cooperation between HBx and USP37."
25347529
Cohesin affects USP37
| 2 5
Cohesin binds USP37. 5 / 6
| 2 3
reach
"Given the mitotic delay and chromosome segregation errors we observed in USP37 depleted cells and that our study and others have implicated cohesion factors in regulating these processes [17, 18], we [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
sparser
"Indeed, cohesin subunits MYC-SMC1, MYC-SCC1, MYC-SA2, and GFP-SMC3 co-immunoprecipitate with FLAG-USP37 in HEK293 cells ( Figure 2 C), confirming that USP37 associates with cohesin."
26299517
sparser
"USP37 associates with cohesin and contributes to sister chromatid resolution."
26299517
sparser
"This discrepancy may be due to cell type–specific or technical differences, since the reported interaction between USP37 and cohesin required ectopic expression of at least one component of the putative complex."
33334891
reach
"This discrepancy may be due to cell type specific or technical differences, since the reported interaction between USP37 and cohesin required ectopic expression of at least one component of the putative complex."
33334891
Cohesin binds USP37 and WAPL. 1 / 1
| 1
sparser
"The authors further demonstrated that USP37 interacts with both cohesin and a negative regulator WAPL, which is required for releasing cohesin from chromatid arms in prophase."
32201366
Cohesin binds SMC1, USP37, and SMC3. 1 / 1
| 1
sparser
"Identifying USP37-interacting partners with proximity-dependent biotin identification (BioID) found that USP37 interacts with the cohesin complex proteins SMC3, SMC1, SSCC1, and SA1/2, as well with the regulators of cohesion WAPL and NIPBL [ xref ]."
| PMC
BTRC affects USP37
6 1 | 1
BTRC binds USP37.
6 | 1
BTRC binds USP37. 7 / 7
6 | 1
biogrid
No evidence text available
23027877
biogrid
No evidence text available
25347529
biogrid
No evidence text available
23027877
reach
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
biogrid
No evidence text available
26299517
biogrid
No evidence text available
23027877
biogrid
No evidence text available
28514442
BTRC ubiquitinates USP37.
1 |
BTRC ubiquitinates USP37. 1 / 1
1 |
APC_C affects USP37
| 6 2
APC_C binds USP37.
| 4 2
APC_C binds USP37. 4 / 4
| 4
reach
"Knockdown of CDH1 markedly reduced the interaction between USP37 and CDC27, suggesting that core APC/C components bind USP37 indirectly through CDH1."
21596315
reach
"EMI1 was not detected in the USP37 and APC/C complex (data not shown) and, similarly, USP37 was not present in the EMI1 and APC/C complex (M.K.S. and P.K.J., unpublished data)."
21596315
reach
"The core components of APC bind with USP37 through CDH1."
| PMC
reach
"Ubiquitin specific protease (USP) 44 has been described in checkpoint responsive regulation of the APC/C by stabilizing the APC-inhibitory MAD2 and CDC20 complex (Joo et al., 2007; Stegmeier et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
APC_C binds CDH1 and USP37. 1 / 1
| 1
sparser
"The core components of APC bind with USP37 through CDH1."
| PMC
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
APC_C inhibits USP37.
| 1
APC_C bound to CDH1 inhibits USP37. 1 / 1
| 1
reach
"USP37 was postulated to directly bind and stabilize cyclin A by stimulating its deubiquitination, promoting its accumulation and progression to G /S.Interestingly, the APC–CDH1 complex degrades USP37 in late mitosis by targeting its KEN box degron."
| PMC
APC_C activates USP37.
| 1
APC_C activates USP37. 1 / 1
| 1
reach
"The inactivation of APC and C-CDH 1 is reinforced through the ubiquitin dependent degradation of CDH1 in S phase by the SKP1-Cullin-F-box (SCF) family ubiquitin ligase, SCF-cyclin F, as well as through deubiquitination of the critical APC and C-CDH 1 target cyclin A2 in late G1 and S phases by the E2F induced deubiquitinase USP37."
33166394
USP37 affects cell migration
| 7
USP37 activates cell migration.
| 5
USP37 activates cell migration. 5 / 5
| 5
reach
"Knockdown of USP37 evidently inhibited cell migration capacity in both MCF and MDA-MB-231 cells (Fig. 3f, g)."
30482232
reach
"USP37 knockdown suppresses breast cancer cell migration and invasion by promoting mesenchymal-epithelial transition."
30482232
reach
"Moreover, we found that knockdown of USP37 suppressed cell migration and invasion in breast cancer cells."
30482232
reach
"USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein"
31998374
reach
"Overexpression of wild-type USP37, but not its catalytically inactive mutant C350S, promotes cancer cell migration."
31911859
USP37 inhibits cell migration.
| 2
USP37 inhibits cell migration. 2 / 2
| 2
reach
"Importantly, depletion of USP37 downregulates endogenous SNAI1 protein and suppresses cell migration, which can be reversed by re-expression of SNAI1."
31911859
reach
"Indeed, USP37 KD reduces cell migration in transwell assays [62]."
| PMC
USP37 affects PCNA
| 3 4
USP37 binds PCNA. 7 / 7
| 3 4
reach
"Additionally, molecular docking studies were conducted to gain insight into the nature of the interaction between USP37 and PCNA."
37118828
sparser
"Additionally, molecular docking studies were conducted to gain insight into the nature of the interaction between USP37 and PCNA."
37118828
sparser
"Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression."
37118828
sparser
"Various molecular assays, including colony formation, immunofluorescence, immunoprecipitation, and DNA replication restart, were employed to examine the physical interaction between USP37 and PCNA, as well as its physiological effects in osteosarcoma cells."
37118828
reach
"Various molecular assays, including colony formation, immunofluorescence, immunoprecipitation, and DNA replication restart, were employed to examine the physical interaction between USP37 and PCNA, as well as its physiological effects in osteosarcoma cells."
37118828
reach
"The interaction between USP37 and PCNA is involved in the regulation of replication stress, and disrupting it could potentially trigger synthetic lethality in osteosarcoma."
37118828
sparser
"The interaction between USP37 and PCNA is involved in the regulation of replication stress, and disrupting it could potentially trigger synthetic lethality in osteosarcoma."
37118828
USP37 affects FBXW11
6 | 1
FBXW11 binds USP37. 6 / 6
6 |
biogrid
No evidence text available
25332235
biogrid
No evidence text available
26299517
biogrid
No evidence text available
25515538
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
FBXW11 binds USP37 and KITLG. 1 / 1
| 1
sparser
"Consistent with this hypothesis, USP37 interacts with components of the SCF in a βTrCP-dependent manner."
23027877
USP37 affects BTRC
6 | 1
BTRC binds USP37. 7 / 7
6 | 1
biogrid
No evidence text available
23027877
biogrid
No evidence text available
25347529
biogrid
No evidence text available
23027877
reach
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
biogrid
No evidence text available
26299517
biogrid
No evidence text available
23027877
biogrid
No evidence text available
28514442
PCNA affects USP37
| 3 4
USP37 binds PCNA. 7 / 7
| 3 4
reach
"Additionally, molecular docking studies were conducted to gain insight into the nature of the interaction between USP37 and PCNA."
37118828
sparser
"Additionally, molecular docking studies were conducted to gain insight into the nature of the interaction between USP37 and PCNA."
37118828
sparser
"Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression."
37118828
sparser
"Various molecular assays, including colony formation, immunofluorescence, immunoprecipitation, and DNA replication restart, were employed to examine the physical interaction between USP37 and PCNA, as well as its physiological effects in osteosarcoma cells."
37118828
reach
"Various molecular assays, including colony formation, immunofluorescence, immunoprecipitation, and DNA replication restart, were employed to examine the physical interaction between USP37 and PCNA, as well as its physiological effects in osteosarcoma cells."
37118828
reach
"The interaction between USP37 and PCNA is involved in the regulation of replication stress, and disrupting it could potentially trigger synthetic lethality in osteosarcoma."
37118828
sparser
"The interaction between USP37 and PCNA is involved in the regulation of replication stress, and disrupting it could potentially trigger synthetic lethality in osteosarcoma."
37118828
FBXW11 affects USP37
6 | 1
FBXW11 binds USP37. 6 / 6
6 |
biogrid
No evidence text available
25332235
biogrid
No evidence text available
26299517
biogrid
No evidence text available
25515538
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
FBXW11 binds USP37 and KITLG. 1 / 1
| 1
sparser
"Consistent with this hypothesis, USP37 interacts with components of the SCF in a βTrCP-dependent manner."
23027877
CDT1 affects USP37
1 | 3 2
USP37 binds CDT1. 6 / 7
1 | 3 2
reach
"In order to confirm this hypothesis, we performed a co-immunoprecipitation assay followed by an immunoblotting analysis, detecting CDT1 and USP37, respectively, in order to evaluate the interactions between USP37 and CDT1."
33898105
sparser
"In order to confirm this hypothesis, we performed a co-immunoprecipitation assay followed by an immunoblotting analysis, detecting CDT1 and USP37, respectively, in order to evaluate the interactions between USP37 and CDT1."
33898105
reach
"USP37 interacted with and deubiquitinated CDT1 to protect it from proteasomal degradation."
33898105
biogrid
No evidence text available
27296872
reach
"USP37 interacts with Cdt1 and is able to de-ubiquitinate Cdt1 invivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin."
27296872
sparser
"Therefore, we further examined the 6 enriched genes in this pathway using an online tool (Chipbase) and found that USP37 and CDT1 were closely associated with lung cancer ( xref D)."
33898105
USP37 affects USP37
| 6
USP37 activates USP37.
| 3
USP37 activates USP37. 3 / 3
| 3
reach
"To further investigate whether USP37 phosphorylation is able to activate USP37, a two-step assay was carried out."
34606619
reach
"Ambiguously, the transcription of USP37 is suppressed in medulloblastoma cells through the activity of RE1 silencing transcription factor to prevent the USP37 mediated stabilization of the cyclin dependent kinase inhibitor p27, which is known to act as a negative regulator of cell cycle XREF_BIBR."
25347529
reach
"Silencing of USP37 expression induced MET including upregulated E-cadherin expression and downregulated N-cadherin expression, while PM reversed MET in silenced USP37 cells."
30482232
USP37 phosphorylates USP37.
| 1
USP37 leads to the phosphorylation of USP37. 1 / 1
| 1
reach
"Interestingly, the USP37 protein and phosphorylated USP37 protein levels remained static in the vector transfected cells irrespective of CDK2 inhibitor treatment thereby highlighting the significance of CDK2 mediated phosphorylation in HBx mediated accumulation of USP37 (XREF_FIG)."
25347529
USP37 inhibits USP37.
| 1
USP37 inhibits USP37. 1 / 1
| 1
reach
"Ambiguously, the transcription of USP37 is suppressed in medulloblastoma cells through the activity of RE1 silencing transcription factor to prevent the USP37 mediated stabilization of the cyclin dependent kinase inhibitor p27, which is known to act as a negative regulator of cell cycle XREF_BIBR."
25347529
USP37 deubiquitinates USP37.
| 1
Ubiquitinated USP37 leads to the deubiquitination of USP37. 1 / 1
| 1
reach
"The level of USP37 ubiquitination was also reduced by mutations in UIM2 or UIM3, suggesting their role in ubiquitination of USP37 itself."
24324262
GLI1 affects USP37
| 4 2
USP37 binds GLI1. 6 / 6
| 4 2
sparser
"MG132, CHX chase, immunofluorescence staining and co-immunoprecipitation assays were used to test the interaction between USP37 and Gli-1."
30482232
reach
"MG132, CHX chase, immunofluorescence staining and co-immunoprecipitation assays were used to test the interaction between USP37 and Gli-1."
30482232
reach
"USP37 also interacted with and stabilized glioma-associated oncogene 1 (Gli-1) protein."
30482232
reach
"Further studies detected that USP37 also interacted with and stabilized Gli-1 protein, which is the main activator of Hedgehog target gene."
30482232
reach
"USP37 interacts with and stabilizes Gli-1 protein."
30482232
sparser
"Co-IP assay indicated that USP37 interacted with Gli-1(Fig. xref )."
30482232
CDKN1B affects USP37
| 1 5
CDKN1B binds USP37. 6 / 6
| 1 5
sparser
"USP37 formed a complex with p27, promoted its deubiquitination and stabilization, and blocked cell proliferation [ xref ]."
34072267
sparser
"Ectopically expressed USP37 formed a complex with p27, promoted its stabilization, blocked cell proliferation and induced the expression of REST-target neuronal differentiation genes."
22665064
reach
"Interaction between USP37 and p27 was also confirmed by co-immunoprecipitation experiments using anti-p27 antibodies or control IgG followed by Western blot analysis using anti-Ub antibodies."
22665064
sparser
"Ectopically expressed wild type USP37 formed a complex with p27, promoted its deubiquitination and stabilization and blocked cell proliferation."
22665064
sparser
"Interaction between USP37 and p27 was also confirmed by co-immunoprecipitation experiments using anti-p27 antibodies or control IgG followed by Western blot analysis using anti-Ub antibodies."
22665064
sparser
"In medulloblastomas, REST expression could decrease cyclin-dependent kinase (CDK)NIB/p27 (a CDK inhibitor) by repressing ubiquitin specific peptidase 37 (USP37), which could form a complex with p27 to promote its deubiquitination and stabilization, and resulting in blocked cell proliferation [ xref ]."
27153061
USP37 affects stemness
| 5
USP37 activates stemness. 5 / 5
| 5
eidos
"Knockdown of USP37 expression hampered cell invasion , stemness , EMT and also resulted in the drug sensitivity to cisplatin ."
30482232
eidos
"USP37 knockdown suppressed stemness and chemo-resistance , which may assist clinical oncologists in designing and testing novel therapeutic strategies ."
30482232
eidos
"The knockdown of USP37 could inhibit the stemness , cell invasion and EMT via downregulation of Hedgehog pathway ."
30482232
eidos
"USP37 knockdown inhibits stemness , cell invasion and EMT via Hedgehog signaling pathway in breast cancer ."
30482232
eidos
"USP37 knockdown inhibits stemness , cell invasion and EMT via Hedgehog signaling pathway in breast cancer ."
| PMC
USP37 affects cell invasion
| 5
USP37 activates cell invasion. 5 / 5
| 5
eidos
"The knockdown of USP37 could inhibit the stemness , cell invasion and EMT via downregulation of Hedgehog pathway ."
30482232
eidos
"These data confirm that USP37 mediates breast cancer stem-like properties , cell invasion and EMT via the Hh pathway ."
30482232
eidos
"Knockdown of USP37 expression hampered cell invasion , stemness , EMT and also resulted in the drug sensitivity to cisplatin ."
30482232
eidos
"USP37 knockdown inhibits stemness , cell invasion and EMT via Hedgehog signaling pathway in breast cancer ."
| PMC
eidos
"USP37 knockdown inhibits stemness , cell invasion and EMT via Hedgehog signaling pathway in breast cancer ."
30482232
USP37 affects apoptotic process
| 5
USP37 activates apoptotic process.
| 3
USP37 activates apoptotic process. 3 / 3
| 3
reach
"Our findings clearly show low levels of USP37 in NSCLC cells, which has synergistic effects on gefitinib-mediated ubiquitination and apoptotic cell death (Figs."
34352998
reach
"Our data indicated that USP37#2 shRNA combined with cisplatin induced the cell apoptosis with an underlying decrease in the Bcl-2/Bax ratio."
30482232
reach
"We detected that USP37#2 shRNA combined with cisplatin treatment induced cell apoptosis with an underlying decrease in Bcl-2/Bax ratio."
30482232
USP37 inhibits apoptotic process.
| 2
reach
"Accumulating evidence has demonstrated that USP37 promotes lung cancer cell proliferation, migration, and invasion XREF_BIBR but inhibits lung cancer cell apoptosis in a deubiquitination dependent manner."
33898105
reach
"USP37 up-regulation promoted the proliferation, cell cycle progression, apoptosis inhibition, migration, invasion, epithelial mesenchymal transition (EMT) and stemness of CRC cells; moreover, USP37 facilitated the angiogenesis of human umbilical vein endothelial cells (HUVECs)."
37424824
USP37 affects UIMC1
| 5
USP37 inhibits UIMC1.
| 3
USP37 inhibits UIMC1. 3 / 3
| 3
reach
"We reasoned that USP26 and USP37 may antagonize the RAP80 dependent sequestration of BRCA1 by removing RNF8 and RNF168 mediated ubiquitylation and thereby promote HR."
26101254
reach
"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."
26101254
reach
"USP26 and USP37 have additionally been shown to impair accumulation of RAP80 and BRCA1 [154]."
32708614
USP37 activates UIMC1.
| 2
USP37 activates UIMC1. 2 / 2
| 2
reach
"Together, this model may explain how USP26 and USP37 limit the repressive impact of RAP80 on HR."
26101254
reach
"Loss of USP26 or USP37 impairs HR by counteracting RAP80 dependent sequestration of BRCA1."
26101254
USP37 affects SMO
| 5
USP37 increases the amount of SMO.
| 2
USP37 increases the amount of SMO. 2 / 2
| 2
reach
"Upregulation of USP37 could enhance protein expression levels of Smo and Gli-1."
30482232
reach
"Interestingly, our data indicated that there was a time-dependent increase in the expression of Smo, Gli-1 and USP37 expression following 24 h, 48 h PM treatment (0.5 μM) (Fig. 6a)."
30482232
USP37 activates SMO.
| 2
USP37 activates SMO. 2 / 2
| 2
reach
"We found that lower expression level of USP37 obviously impaired the expression of Hh targets (Smo and Gli-1) and cell proliferation marker Ki-67 in the tumor tissues as seen by immunohistochemical staining (Fig. 8e)."
30482232
reach
"Knockdown of USP37 significantly decreased hedgehog (Hh) pathway components Smo and Gli-1."
30482232
USP37 inhibits SMO.
| 1
USP37 inhibits SMO. 1 / 1
| 1
reach
"Knockdown of USP37 significantly decreased hedgehog (Hh) pathway components Smo and Gli-1."
30482232
USP37 affects REST
| 3 1
USP37 binds REST.
| 1 1
USP37 binds REST. 2 / 3
| 1 1
sparser
"However, the association of USP37 with REST needs further investigation."
32720471
reach
"Like p27, a reciprocal association between USP37 and REST is present, and REST KD increases USP37 mRNA levels."
| PMC
USP37 increases the amount of REST.
| 1
Modified USP37 increases the amount of REST. 1 / 1
| 1
reach
"Unexpectedly, Q-RT-PCR analyses showed that WT USP37 expression promoted a 2.7-8 fold increase in expression of the REST target genes Syn1, BDNF and SCG10 respectively, relative to vector transfected cells."
22665064
USP37 activates REST.
| 1
USP37 activates REST. 1 / 1
| 1
reach
"In contrast, ectopic expression of a USP37 transgene carrying a mutation in a conserved cysteine residue failed to rescue REST dependent effects on p27, cell proliferation and neuronal differentiation."
22665064
USP37 affects APC
| 5
USP37 activates APC.
| 3
USP37 activates APC. 3 / 3
| 3
reach
"Other APC CDH1 substrates, including CDC20, CDC6, PLK1, Aurora kinase A, and SKP2, were not decreased by USP37 knockdown, indicating a specific effect of USP37 on cyclin A abundance.Coimmunoprecipitat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
reach
"Deubiquitinase USP37 is activated by CDK2 to antagonize APC (CDH1) and promote S phase entry [XREF_BIBR]."
25972356
reach
"Deubiquitinase USP37 is activated by CDK2 to antagonize APC (CDH1) and promote S phase entry."
21596315
USP37 inhibits APC.
| 2
USP37 inhibits APC. 2 / 2
| 2
reach
"Deubiquitinase USP37 is activated by CDK2 to antagonize APC (CDH1) and promote S phase entry."
21596315
reach
"Deubiquitinase USP37 is activated by CDK2 to antagonize APC (CDH1) and promote S phase entry [XREF_BIBR]."
25972356
USP37 affects 14-3-3γ
| 5
USP37 binds 14-3-3γ.
| 4
USP37 binds 14-3-3γ. 3 / 3
| 3
sparser
"To determine the functional significance of the interaction between USP37 and 14-3-3γ, we assessed whether the polyubiquitination of 14-3-3γ was deubiquitinated by USP37."
26427597
sparser
"The results showed that of these six isoforms, only 14-3-3γ bound to USP37, demonstrating that 14-3-3γ is a unique binding partner of USP37 (Figure xref , lane 7)."
26427597
sparser
"The identification of the interaction between USP37 and 14-3-3γ led us to investigate whether USP37 was associated with cell proliferation and migration via the regulation of 14-3-3γ."
26427597
USP37 binds MYC, Hemagglutinins, and 14-3-3γ. 1 / 1
| 1
sparser
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3γ and Myc-USP37."
26427597
USP37 ubiquitinates 14-3-3γ.
| 1
USP37 ubiquitinates 14-3-3γ. 1 / 1
| 1
sparser
"The findings on the regulation of 14-3-3γ ubiquitination by USP37 establish a new role for USP37 in cancer cell proliferation, indicating that ubiquitination, a PTM, has an important role in cancer."
26427597
ZBTB16 affects USP37
| 2 1
ZBTB16 binds USP37. 3 / 4
| 2 1
reach
"We showed that USP37 interacted with PLZF and RARA through the PLZF moiety and sustained PLZF and RARA steady state levels."
23208507
reach
"In contrast, the deubiquitinating enzyme USP37 interacts with Plzf which increases Plzf protein stability [XREF_BIBR]."
24359566
sparser
"In contrast, the deubiquitinating enzyme USP37 interacts with Plzf which increases Plzf protein stability [ xref ]."
24359566
USP37
1 | 1
USP37 binds.
1 |
USP37 binds USP37. 1 / 3
1 |
biogrid
No evidence text available
21596315
USP37 translocates.
| 1
USP37 translocates from the nucleoplasm to the cytoplasm. 1 / 1
| 1
sparser
"A recent study demonstrated that HBx, an oncoprotein of the hepatitis B virus and a regulator of hepatocarcinogenesis, promoted the translocation of USP37 from the nucleoplasm to the cytoplasm and that the degradation of USP37 seemed to be prevented by the E3 ligases, APC/CDH1 and SCF/β-TrCP [ xref ]."
26427597
USP37 affects UBC
4 |
UBC binds USP37. 4 / 4
4 |
biogrid
No evidence text available
23287719
biogrid
No evidence text available
24324262
biogrid
No evidence text available
24324262
biogrid
No evidence text available
24324262
USP37 affects Snail1 protein
| 4
USP37 increases the amount of Snail1 protein.
| 2
Modified USP37 increases the amount of Snail1 protein. 2 / 2
| 2
reach
"As shown in Figure XREF_FIG D and XREF_SUPPLEMENTARY A, depletion of USP37 in SGC7901 and HEK293T cells significantly reduced Snail1 protein expression, whereas enhanced USP37 expression in AGS and HEK293T cells dramatically upregulated the Snail1 protein levels."
33391500
reach
"Overexpression of USP37 in SGC7901-shRNA cells restores Snail1 protein levels, which shows that the USP37-Snail1 axis plays a vital role in PLAGL2 mediated Snail1 stabilization."
33391500
USP37 deubiquitinates Snail1 protein.
| 1
USP37 deubiquitinates Snail1 protein. 1 / 1
| 1
reach
"PLAGL2 activated the transcription of deubiquitinase USP37, which then interacted with and deubiquitinated Snail1 protein directly."
33391500
USP37 decreases the amount of Snail1 protein.
| 1
USP37 decreases the amount of Snail1 protein. 1 / 1
| 1
reach
"As shown in Figure XREF_FIG D and XREF_SUPPLEMENTARY A, depletion of USP37 in SGC7901 and HEK293T cells significantly reduced Snail1 protein expression, whereas enhanced USP37 expression in AGS and HEK293T cells dramatically upregulated the Snail1 protein levels."
33391500
USP37 affects RAP80-BRCA1
| 1 3
USP37 inhibits RAP80-BRCA1. 4 / 4
| 1 3
eidos
"USP37 and USP36 prevent excessive spreading of RAP80-BRCA1 from DSBs ."
| PMC
reach
"We demonstrate that USP26 and USP37 prevent excessive spreading of RAP80-BRCA1 from DSBs."
26101254
reach
"USP26 or USP37 antagonize ubiquitin dependent spreading of RAP80-BRCA1."
26101254
reach
"USP37 and USP36 prevent excessive spreading of RAP80-BRCA1 from DSBs."
| PMC
USP37 affects Flag
| 4
USP37 binds Flag. 4 / 4
| 4
sparser
"HA-Snail and Flag-USP37 were transiently expressed either separated or combined."
31998374
sparser
"Our studies showed that ectopically expressed Flag-USP37 was able to immunoprecipitate endogenous Snail protein in lung cancer H1299 cells ( xref )."
31998374
sparser
"We also expressed GST-Snail in E. coli BL21 cells, which was mixed with Flag-USP37 protein purified from 293T cells, and co-IP assays were carried out with GST beads."
31998374
sparser
"Plasmids encoding Flag-USP37 and HA-Snail were co-expressed in 293T cells."
31998374
USP37 affects FZR1
4 |
USP37 binds FZR1. 4 / 4
4 |
biogrid
No evidence text available
25347529
biogrid
No evidence text available
21596315
biogrid
No evidence text available
21596315
biogrid
No evidence text available
28514442
USP37 affects CDK2
2 | 1 1
CDK2 binds USP37. 4 / 4
2 | 1 1
biogrid
No evidence text available
21596315
biogrid
No evidence text available
26299517
sparser
"Since USP37 S 628 exists within a minimum CDK phosphorylation motif (S/T-P) ( Dephoure et al., 2008 ), CDK2 interacts with USP37 ( Figure 1 C), and CDK2 is active in G1/S, we investigated whether CDK[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
reach
"Since USP37 S 628 exists within a minimum CDK phosphorylation motif (S/T-P) (Dephoure et al., 2008), CDK2 interacts with USP37, and CDK2 is active in G1/S, we investigated whether CDK2 phosphorylates [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
USP37 affects CDC27
2 | 1 1
CDC27 binds USP37. 4 / 4
2 | 1 1
biogrid
No evidence text available
21596315
reach
"Knockdown of CDH1 markedly reduced the interaction between USP37 and CDC27, suggesting that core APC/C components bind USP37 indirectly through CDH1."
21596315
sparser
"Knockdown of CDH1 markedly reduced the interaction between USP37 and CDC27 ( Figure 1 F), suggesting that core APC/C components bind USP37 indirectly through CDH1."
21596315
biogrid
No evidence text available
26299517
USP37 affects CDC20
1 | 2 1
CDC20 binds USP37. 3 / 3
1 | 2
reach
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
reach
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
biogrid
No evidence text available
21596315
CDC20 binds CDH1 and USP37. 1 / 1
| 1
sparser
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
UBC affects USP37
4 |
UBC binds USP37. 4 / 4
4 |
biogrid
No evidence text available
23287719
biogrid
No evidence text available
24324262
biogrid
No evidence text available
24324262
biogrid
No evidence text available
24324262
TFDP1 affects USP37
4 |
TFDP1 decreases the amount of USP37. 4 / 4
4 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Flag affects USP37
| 4
USP37 binds Flag. 4 / 4
| 4
sparser
"HA-Snail and Flag-USP37 were transiently expressed either separated or combined."
31998374
sparser
"Our studies showed that ectopically expressed Flag-USP37 was able to immunoprecipitate endogenous Snail protein in lung cancer H1299 cells ( xref )."
31998374
sparser
"We also expressed GST-Snail in E. coli BL21 cells, which was mixed with Flag-USP37 protein purified from 293T cells, and co-IP assays were carried out with GST beads."
31998374
sparser
"Plasmids encoding Flag-USP37 and HA-Snail were co-expressed in 293T cells."
31998374
FZR1 affects USP37
4 |
USP37 binds FZR1. 4 / 4
4 |
biogrid
No evidence text available
25347529
biogrid
No evidence text available
21596315
biogrid
No evidence text available
21596315
biogrid
No evidence text available
28514442
E3_Ub_ligase affects USP37
| 3 1
E3_Ub_ligase activates USP37.
| 2
E3_Ub_ligase activates USP37. 2 / 2
| 2
reach
"E3 ligases that are active during exit from mitosis and therefore might target USP37 for degradation include beta-TRCP1, beta-TRCP2, APC CDC20, and APC CDH1 (Frescas and Pagano, 2008; Peters, 2002)."
21596315
reach
"The dichotomy in the action of two E3 ligases targeting USP37 further inspired us to investigate the possibility of direct or indirect interaction between HBx and USP37 which could reveal a bigger role of HBx in protection of USP37."
25347529
E3_Ub_ligase ubiquitinates USP37.
| 1
E3_Ub_ligase ubiquitinates USP37. 1 / 1
| 1
reach
"Inactive USP37 is ubiquitinated by E3 ubiquitin ligase APC and degraded in the proteasome (Huang et al., 2011)."
33169399
E3_Ub_ligase binds USP37.
| 1
sparser
"Mutations in UIM2 and UIM3 abrogate binding to K48- and K63-linked Ub 4 chains, similar to published work [ 16 ], but also to K11-linked Ub 4 chains, which are produced by APC CDH1 , the E3 ligase a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
CDC27 affects USP37
2 | 1 1
CDC27 binds USP37. 4 / 4
2 | 1 1
biogrid
No evidence text available
21596315
reach
"Knockdown of CDH1 markedly reduced the interaction between USP37 and CDC27, suggesting that core APC/C components bind USP37 indirectly through CDH1."
21596315
sparser
"Knockdown of CDH1 markedly reduced the interaction between USP37 and CDC27 ( Figure 1 F), suggesting that core APC/C components bind USP37 indirectly through CDH1."
21596315
biogrid
No evidence text available
26299517
CDC20 affects USP37
1 | 2 1
CDC20 binds USP37. 3 / 3
1 | 2
reach
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
reach
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
biogrid
No evidence text available
21596315
CDC20 binds CDH1 and USP37. 1 / 1
| 1
sparser
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
14-3-3γ affects USP37
| 4
USP37 binds 14-3-3γ. 3 / 3
| 3
sparser
"To determine the functional significance of the interaction between USP37 and 14-3-3γ, we assessed whether the polyubiquitination of 14-3-3γ was deubiquitinated by USP37."
26427597
sparser
"The results showed that of these six isoforms, only 14-3-3γ bound to USP37, demonstrating that 14-3-3γ is a unique binding partner of USP37 (Figure xref , lane 7)."
26427597
sparser
"The identification of the interaction between USP37 and 14-3-3γ led us to investigate whether USP37 was associated with cell proliferation and migration via the regulation of 14-3-3γ."
26427597
USP37 binds MYC, Hemagglutinins, and 14-3-3γ. 1 / 1
| 1
sparser
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3γ and Myc-USP37."
26427597
Valproic acid affects USP37
3 |
Valproic acid decreases the amount of USP37. 3 / 3
3 |
ctd
No evidence text available
27188386
ctd
No evidence text available
28001369
ctd
No evidence text available
23179753
Sodium arsenate affects USP37
3 |
Sodium arsenate increases the amount of USP37.
2 |
Sodium arsenate increases the amount of USP37. 2 / 2
2 |
ctd
No evidence text available
21795629
ctd
No evidence text available
30953684
Sodium arsenate decreases the amount of USP37.
1 |
Sodium arsenate decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
21795629
Hsa-miR-19b-3p affects USP37
3 |
Hsa-miR-19b-3p decreases the amount of USP37. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
22473208
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
23313552
Gefitinib affects USP37
| 3
Gefitinib decreases the amount of USP37.
| 2
Gefitinib decreases the amount of USP37. 2 / 2
| 2
reach
"Expression level of USP37 is negatively regulated by gefitinib in a time-dependent manner, and deletion of USP37 in gefitinib-treated cells synergistically enhances ubiquitination."
34352998
reach
"Gefitinib reduced expression levels of USP37, which mediated EGFR degradation similar to gefitinib."
34352998
Gefitinib activates USP37.
| 1
Gefitinib activates USP37. 1 / 1
| 1
reach
"Next, we investigated the upstream modulators of gefitinib-mediated USP37 down-regulation."
34352998
USP37 affects migration
| 3
USP37 activates migration. 3 / 3
| 3
eidos
"Accumulating evidence has demonstrated that USP37 promotes lung cancer cell proliferation , migration , and invasion16 but inhibits lung cancer cell apoptosis in a deubiquitination-dependent manner.19 Therefore , it is possible that IH-mediated miR-320b reduction in lung cancer cells resulted in the upregulation of USP37 , which further promoted cancer cell proliferation , invasion , and survival ."
33898105
eidos
"In contrast , USP37 upregulation promotes EMT , migration , and invasion [ 39 ] ."
| PMC
eidos
"On the contrary , upregulation of USP37 promoted EMT , migration and invasion ."
30482232
USP37 affects doxorubicin
| 3
USP37 activates doxorubicin.
| 2
USP37 activates doxorubicin. 2 / 2
| 2
reach
"USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin."
33390801
reach
"The expression levels of USP37 in both MCF-7 and MCF-7 and ADR cells increased significantly with the exposure to adriamycin in a dose dependent manner."
33390801
USP37 inhibits doxorubicin.
| 1
USP37 inhibits doxorubicin. 1 / 1
| 1
reach
"It was verified by the observation that USP37 downregulation elevated the inhibitory effects of adriamycin on breast cancer cells, suppressed cell proliferation caused by cell cycle arrest in G1/S transition, as well as induced apoptosis."
33390801
USP37 affects SMC3
2 | 1
USP37 binds SMC3. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
26299517
Cohesin binds SMC1, USP37, and SMC3. 1 / 1
| 1
sparser
"Identifying USP37-interacting partners with proximity-dependent biotin identification (BioID) found that USP37 interacts with the cohesin complex proteins SMC3, SMC1, SSCC1, and SA1/2, as well with the regulators of cohesion WAPL and NIPBL [ xref ]."
| PMC
USP37 affects RARA
| 3
USP37 activates RARA. 3 / 3
| 3
reach
"Furthermore, overexpression or depletion of USP37 caused an increase or decrease of PLZF and RARA protein half-life, correlating with down- or upregulation of PLZF and RARA poly-ubiquitination, respectively."
23208507
reach
"It was reported that USP37 induced the stability of the oncogenic fusion protein PLZF and RARA."
26427597
reach
"Subsequently, it was verified that USP37 expression modulated the oncogenic fusion protein PLZF/RARA stability and cell transformation potential in PLZF/RARA-associated acute promyelocytic leukemia [33]."
30482232
USP37 affects RAD51
| 3
USP37 activates RAD51. 3 / 3
| 3
reach
"Interestingly, in contrast with initial findings assessing overexpression of these DUBs, knockdown of either USP26 or USP37 impairs accumulation of key HR factors including RAD51 as well as PALB2, CtIP, and RPA [154]."
32708614
reach
"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."
26101254
reach
"Loss of USP26 and USP37 function markedly impairs the assembly of PALB2, RAD51 and efficient HR."
26101254
USP37 affects PLAGL2
| 2 1
USP37 binds PLAGL2. 3 / 3
| 2 1
reach
"The ChIP assay revealed that PLAGL2 was bound to the USP37 promoter region."
33391500
reach
"PLAGL2 specifically binds to the GRGGC(N)6-8RGGK consensus sequences in the USP37 promoter region and activates its transcription, subsequently stabilizing SNAI1 and promoting EMT in GC cells [64]."
| PMC
sparser
"The ChIP assay revealed that PLAGL2 was bound to the USP37 promoter region (Figure xref C)."
33391500
USP37 affects PALB2
| 3
USP37 activates PALB2. 3 / 3
| 3
reach
"Interestingly, in contrast with initial findings assessing overexpression of these DUBs, knockdown of either USP26 or USP37 impairs accumulation of key HR factors including RAD51 as well as PALB2, CtIP, and RPA [154]."
32708614
reach
"Loss of USP26 and USP37 function markedly impairs the assembly of PALB2, RAD51 and efficient HR."
26101254
reach
"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."
26101254
USP37 affects Neoplasm Metastasis
| 1 2
USP37 activates Neoplasm Metastasis.
| 1 1
reach
"This was further validated in an orthotopic mouse model in which USP37 depletion reduces primary kidney tumorigenesis and decreases lung metastasis."
| PMC
eidos
"USP37 is a modulator of the epithelial-mesenchymal transition and metastasis ."
| PMC
USP37 inhibits Neoplasm Metastasis.
| 1
USP37 inhibits Neoplasm Metastasis. 1 / 1
| 1
reach
"Depletion of USP37 impairs ccRCC growth in 2D and 3D growth assays and in vivo kidney tumorigenesis and lung metastasis [XREF_BIBR]; therefore, inhibiting USP37 could be a viable therapeutic approach in VHL deficient or HIF-2alpha-dependent tumors."
| PMC
USP37 affects Hedgehog
| 3
USP37 activates Hedgehog.
| 2
USP37 activates Hedgehog. 2 / 2
| 2
reach
"These findings are further supported by the ability of USP37 to participate in Hh signaling pathway in breast cancer."
30482232
reach
"USP37 mediates hedgehog signaling pathway through stabilizing components such as Smo and GLI-1."
32426267
USP37 increases the amount of Hedgehog.
| 1
USP37 increases the amount of Hedgehog. 1 / 1
| 1
reach
"We found that lower expression level of USP37 obviously impaired the expression of Hh targets (Smo and Gli-1) and cell proliferation marker Ki-67 in the tumor tissues as seen by immunohistochemical staining (Fig. 8e)."
30482232
USP37 affects Cyclin_A
| 1 2
USP37 binds Cyclin_A.
| 2
sparser
"USP37 binds, deubiquitinates, and stabilizes cyclin A, thereby regulating the G1/S transition [ xref ]."
34072267
sparser
"Coimmunoprecipitation experiments indicated an interaction between endogenous USP37 and cyclin A in 293T cells ( Figure 3 C), making cyclin A a potential USP37 substrate."
21596315
USP37 deubiquitinates Cyclin_A.
| 1
USP37 deubiquitinates Cyclin_A. 1 / 1
| 1
reach
"For example, USP37 regulates the cell cycle by deubiquitinating and stabilizing cyclin A, which enables cells to enter into S phase (151, 152)."
34391779
USP37 affects Cell Survival
| 3
USP37 activates Cell Survival.
| 2
USP37 bound to HA-14-3-3gamma activates Cell Survival. 1 / 1
| 1
reach
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3gamma and Myc-USP37."
26427597
USP37 activates Cell Survival. 1 / 1
| 1
reach
"Previous studies reported that USP37 increased the Warburg effect and cell viability by repressing ubiquitin mediated degradation of c-Myc XREF_BIBR."
33391500
USP37 inhibits Cell Survival.
| 1
USP37 inhibits Cell Survival. 1 / 1
| 1
reach
"The depletion of USP37 reduced the cell viability compared with a control."
26427597
USP37 affects CDH2
| 3
USP37 increases the amount of CDH2. 3 / 3
| 3
reach
"Immunofluorescence assay showed that overexpression of USP37 further inhibited E-cadherin expression and upregulated N-cadherin expression (Fig. 3j)."
30482232
reach
"Silencing of USP37 expression induced MET including upregulated E-cadherin expression and downregulated N-cadherin expression, while PM reversed MET in silenced USP37 cells."
30482232
reach
"As shown in Fig. 3c and d, knockdown of USP37 significantly decreased Snail1, N-cadherin and Vimentin expression, but increased E-cadherin expression levels."
30482232
USP37 affects CDC73
| 2 1
USP37 binds CDC73.
| 1 1
CDC73 binds USP37. 2 / 2
| 1 1
sparser
"The biochemical interaction between the USP37 and CDC73 and their reciprocal binding domains were studied."
35742816
reach
"The biochemical interaction between the USP37 and CDC73 and their reciprocal binding domains were studied."
35742816
USP37 deubiquitinates CDC73.
| 1
USP37 deubiquitinates CDC73. 1 / 1
| 1
reach
"USP37 Deubiquitinates CDC73 in HPT-JT Syndrome."
35742816
USP37 affects APC CDH1
| 3
USP37 inhibits APC CDH1.
| 1
USP37 inhibits APC CDH1. 1 / 1
| 1
reach
"In addition, USP37 preferentially antagonized the activity of APC CDH1 versus APC CDC20."
21596315
USP37 increases the amount of APC CDH1.
| 1
USP37 increases the amount of APC CDH1. 1 / 1
| 1
reach
"We show that USP37 is a DUB that associates with and antagonizes APC CDH1 following E2F mediated USP37 transcription in G1."
21596315
USP37 activates APC CDH1.
| 1
USP37 activates APC CDH1. 1 / 1
| 1
reach
"We now describe an autonomous APC CDH1 activation loop mediated by the destruction of USP37, which is akin to the destruction of Acm1 in yeast."
21596315
UIM3 affects USP37
| 1 2
UIM3 activates USP37.
| 1 1
UIM3 activates USP37. 2 / 2
| 1 1
eidos
"Furthermore , UIM2 and UIM3 selectively bind to the proximal ubiquitin of K48-linked chains to enhance cleavage by USP37 , whereas UIM1 is not involved in substrate recognition [ 94 ] ."
| PMC
reach
"Therefore, the difference in the ability of the UIMs to bind ubiquitin plays a differential role on the kinetic parameters of USP37 depending on the type of ubiquitin chain, shedding light on the mechanism of substrate selection by USP37.When individual UIM mutants were tested, the authors found that UIM2 and UIM3 modulate the ability of USP37 to cleave all ubiquitin chain types, in contrast with that of UIM1."
| PMC
UIM3 decreases the amount of USP37.
| 1
UIM3 decreases the amount of USP37. 1 / 1
| 1
reach
"The level of USP37 ubiquitination is also reduced by mutations in UIM2 or UIM3, suggesting that they play a role in the ubiquitination of USP37 itself."
| PMC
SMC3 affects USP37
2 | 1
USP37 binds SMC3. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
26299517
Cohesin binds SMC1, USP37, and SMC3. 1 / 1
| 1
sparser
"Identifying USP37-interacting partners with proximity-dependent biotin identification (BioID) found that USP37 interacts with the cohesin complex proteins SMC3, SMC1, SSCC1, and SA1/2, as well with the regulators of cohesion WAPL and NIPBL [ xref ]."
| PMC
HNF4A affects USP37
3 |
HNF4A decreases the amount of USP37. 3 / 3
3 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
14-3-3gamma affects USP37
| 3
USP37 binds 14-3-3gamma. 3 / 3
| 3
reach
"The results showed that of these six isoforms, only 14-3-3gamma bound to USP37, demonstrating that 14-3-3gamma is a unique binding partner of USP37."
26427597
reach
"Reciprocal co-IP confirmed that these two proteins interacted with each other, with USP37 strongly binding to 14-3-3gamma."
26427597
reach
"To determine the functional significance of the interaction between USP37 and 14-3-3gamma, we assessed whether the polyubiquitination of 14-3-3gamma was deubiquitinated by USP37."
26427597
Hsa-miR-30c-5p affects USP37
2 |
Hsa-miR-30c-5p decreases the amount of USP37. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
22473208
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-19a-3p affects USP37
2 |
Hsa-miR-19a-3p decreases the amount of USP37. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
22473208
USP37 affects tumorigenicity
| 2
USP37 activates tumorigenicity. 2 / 2
| 2
eidos
"USP37 knockdown inhibits tumorigenicity and increases sensitivity to cisplatin in vivo ."
30482232
eidos
"Additionally , USP37 knockdown inhibited tumorigenicity and increased anticancer effect of cisplatin in vivo ."
30482232
USP37 affects tumor growth MCF-7 ADR cells
| 2
USP37 activates tumor growth MCF-7 ADR cells. 2 / 2
| 2
eidos
"Further experiment results showed that the downregulation of USP37 increased the sensitivity of MCF-7 / ADR cells to adriamycin in vitro and inhibited the tumor growth of MCF-7 / ADR cells in vivo ."
33390801
eidos
"By in vivo assay , USP37 downregulation also suppressed the tumor growth of MCF-7 / ADR cells ."
33390801
USP37 inhibits smoothened signaling pathway. 1 / 1
| 1
reach
"Downregulation of USP37 inhibits stemness, cell invasion and EMT via hedgehog signaling pathway in breast cancer."
30482232
USP37 activates smoothened signaling pathway. 1 / 1
| 1
eidos
"USP37 mediates hedgehog signaling pathway through stabilizing components such as Smo and GLI-1 ."
32426267
USP37 affects purmorphamine
| 2
USP37 activates purmorphamine. 2 / 2
| 2
reach
"Figure 6c shows that silencing of USP37 expression could reverse the positive effects of PM on the Hh pathway."
30482232
reach
"Meanwhile, knockdown of USP37 reversed the effect of PM on the EMT markers."
30482232
USP37 affects polyubiquitin chains
| 2
USP37 inhibits polyubiquitin chains.
| 1
USP37 inhibits polyubiquitin chains. 1 / 1
| 1
reach
"Interestingly, RAP80 's access to polyubiquitin chains assembled by RNF8 and RNF168 is regulated by HR promoting factors such as RNF169, which competes with RAP80 for binding sites on polyubiquitin [XREF_BIBR], and the DUBs USP26 and USP37, which degrade polyubiquitin chains to reduce RAP80 accumulation [XREF_BIBR]."
28681078
USP37 activates polyubiquitin chains.
| 1
USP37 activates polyubiquitin chains. 1 / 1
| 1
reach
"The DUB USP37 directly regulates S-phase entry through antagonising activity of the APC/C CDH1 in G 1 by removing polyubiquitin chains to stabilise CCNA [XREF_BIBR]."
28900014
USP37 affects gefitinib
| 2
USP37 activates gefitinib. 2 / 2
| 2
reach
"miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non-Small Cell Lung Cancer Cells by Targeting USP37."
34352998
reach
"These results suggest that the up-regulation of ubiquitination and autophagy by miR-4487/USP37 enhances gefitinib-mediated cytotoxicity and apoptotic cell death."
34352998
USP37 affects STAG2
2 |
STAG2 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
26299517
USP37 affects SKP1
2 |
SKP1 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
23027877
biogrid
No evidence text available
26299517
USP37 affects S phase
| 2
USP37 activates S phase. 2 / 2
| 2
reach
"The deubiquitinase (DUB) USP37 has been found to stabilize cyclin A by removing the polyubiquitin from the latter and, hence, accelerates entry into S phase (Huang et al., 2011)."
30510918
reach
"USP37 was also reported to remove ubiquitin chains from Cyclin A and overexpression of USP37 promotes Cyclin A accumulation and accelerated S phase entry, suggesting a potentially key role for USP37 in regulating the cell cycle in a cancer setting (73)."
34606619
USP37 affects RAD21
2 |
USP37 binds RAD21. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
26299517
USP37 affects PTCH1
| 2
USP37 binds PTCH1. 2 / 2
| 2
sparser
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., xref ; von Mikecz, xref ; Saxena and Kumar, xref )."
30510918
sparser
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
USP37 affects PRPF19
1 | 1
USP37 binds PRPF19.
1 |
PRPF19 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 activates PRPF19.
| 1
USP37 activates PRPF19. 1 / 1
| 1
reach
"We previously demonstrated that ubiquitin carboxyl-terminal hydrolase 37 (UCH37), a member of the DUBs, promoted invasion and postoperative recurrence of HCC, and pre-mRNA processing factor 19 (Prp19) may function as its downstream effecter [XREF_BIBR]."
26959880
USP37 affects Neoplasms
| 2
USP37 inhibits Neoplasms.
| 1
USP37 inhibits Neoplasms. 1 / 1
| 1
reach
"USP37 KD in MCF7 cells also increased sensitivity to chemotherapeutic agents such as cisplatin by decreasing the BCL2/BAX ratio and attenuating tumor growth in vivo [39]."
| PMC
USP37 activates Neoplasms.
| 1
USP37 activates Neoplasms. 1 / 1
| 1
reach
"We found that lower expression level of USP37 obviously impaired the expression of Hh targets (Smo and Gli-1) and cell proliferation marker Ki-67 in the tumor tissues as seen by immunohistochemical staining (Fig. 8e)."
30482232
USP37 affects Medulloblastoma
| 2
reach
"The USP37 promoter in MB possesses a significant level of histone H3K9 trimethylation, which was considerably diminished upon treatment of the DAOY cells with the G9a inhibitor UNC0638."
30560106
reach
"Constitutive expression of USP37 promotes p27 deubiquitination in medulloblastoma cells, whereas a catalytically dead USP37 mutant is unable to stabilize p27.Dobson et al. further explored the molecular basis of REST-induced USP37 downregulation and found that USP37 supresses medulloblastoma tumor growth in an orthotopic mouse model by modulating its downstream targets [87]."
| PMC
USP37 affects MITF
| 1 1
USP37 inhibits MITF. 2 / 2
| 1 1
reach
"An RNAi screen in HeLa cells of 296 genes that increase the MI revealed that depletion of USP37 markedly increases the MI, suggesting that it plays a role in mitotic progression [76]."
| PMC
eidos
"An RNAi screen in HeLa cells of 296 genes that increase the MI revealed that depletion of USP37 markedly increases the MI , suggesting that it plays a role in mitotic progression [ 76 ] ."
| PMC
USP37 affects KITLG
| 1 1
USP37 inhibits KITLG.
| 1
USP37 inhibits KITLG. 1 / 1
| 1
reach
"However, HBx escorts USP37 from the nucleus, downregulates CDH1, and prevents its SCF mediated degradation via increased CDK2-mediated phosphorylation [24]."
| PMC
USP37 binds KITLG.
| 1
FBXW11 binds USP37 and KITLG. 1 / 1
| 1
sparser
"Consistent with this hypothesis, USP37 interacts with components of the SCF in a βTrCP-dependent manner."
23027877
USP37 affects EPAS1
| 1 1
USP37 activates EPAS1. 2 / 2
| 1 1
eidos
"Among these DUBs , USP37 induced the most significant increase in HIF2alpha levels ( Fig. 2D ) ."
| PMC
reach
"As a result, USP37 promotes HIF2alpha protein stability in an enzymatically dependent manner, and depletion of USP37 leads to HIF2alpha down-regulation in ccRCC."
32461361
reach
"USP37 and USP26 are recruited to DSBs to remove RNF168-induced ubiquitin conjugates from the BRCA1-A complex, whereas loss of USP37 impairs DSB repair."
| PMC
reach
"Moreover, over-expression of USP37 increased DSB end resection in control cells but not BLM depletion cells (Supplementary Figure S4K, L)."
34606619
USP37 affects Carcinogenesis
| 1 1
USP37 activates Carcinogenesis. 2 / 2
| 1 1
reach
"This was further validated in an orthotopic mouse model in which USP37 depletion reduces primary kidney tumorigenesis and decreases lung metastasis."
| PMC
eidos
"207 In addition to Fbw7 , other E3 ligases , such as beta-TrCP1 , CHIP and FBXO32 , can also ubiquitinate c-Myc , mediate its subsequent degradation and inhibit tumorigenesis.208-210 Moreover , the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc.211 ,212 By mass spectrometry , SUMO ligase protein inhibitor of activated STAT ( PIAS ) and Sentrin-specific protease 7 ( SENP7 ) were also found to control the SUMOylation of c-Myc at K326 and regulate its ubiquitination and degradation ( Fig. 2c ) .213 Ubiquitination regulates p53 p53 , one of the most important tumor suppressors , works in multiple cellular processes , such as cell cycle regulation , DNA repair and apoptosis ."
32140262
USP37 affects CCNA2
2 |
CCNA2 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
21596315
biogrid
No evidence text available
21596315
USP37 affects ANAPC7
2 |
ANAPC7 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
21596315
USP37 affects ANAPC5
2 |
ANAPC5 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
21596315
UIM2 affects USP37
| 1 1
UIM2 activates USP37. 2 / 2
| 1 1
eidos
"Furthermore , UIM2 and UIM3 selectively bind to the proximal ubiquitin of K48-linked chains to enhance cleavage by USP37 , whereas UIM1 is not involved in substrate recognition [ 94 ] ."
| PMC
reach
"Therefore, the difference in the ability of the UIMs to bind ubiquitin plays a differential role on the kinetic parameters of USP37 depending on the type of ubiquitin chain, shedding light on the mechanism of substrate selection by USP37.When individual UIM mutants were tested, the authors found that UIM2 and UIM3 modulate the ability of USP37 to cleave all ubiquitin chain types, in contrast with that of UIM1."
| PMC
TFDP2 affects USP37
2 |
TFDP2 decreases the amount of USP37. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
STAG2 affects USP37
2 |
STAG2 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
26299517
SKP1 affects USP37
2 |
SKP1 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
23027877
biogrid
No evidence text available
26299517
RB1 affects USP37
2 |
RB1 decreases the amount of USP37. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
RAD21 affects USP37
2 |
USP37 binds RAD21. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
26299517
PTCH1 affects USP37
| 2
USP37 binds PTCH1. 2 / 2
| 2
sparser
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., xref ; von Mikecz, xref ; Saxena and Kumar, xref )."
30510918
sparser
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
PLK1 affects USP37
| 1 1
PLK1 leads to the phosphorylation of USP37. 2 / 2
| 1 1
reach
"The underlying mechanism involves PLK1 kinase-mediated phosphorylation of USP37 and its binding to βTrCP, promoting ubiquitination and degradation (Fig. 1)."
| PMC
sparser
"The underlying mechanism involves PLK1 kinase-mediated phosphorylation of USP37 and its binding to βTrCP, promoting ubiquitination and degradation (Fig. xref )."
| PMC
Neoplasms affects USP37
| 2
Neoplasms inhibits USP37.
| 1
Neoplasms inhibits USP37. 1 / 1
| 1
reach
"Furthermore, miR-320b overexpression reduces IH-induced tumor growth by promoting USP37 downregulation."
| PMC
Neoplasms activates USP37.
| 1
Neoplasms activates USP37. 1 / 1
| 1
reach
"Furthermore, miR-320b overexpression reduces IH-induced tumor growth by promoting USP37 downregulation."
| PMC
NRF1 affects USP37
2 |
NRF1 decreases the amount of USP37. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal activates USP37. 2 / 2
| 2
reach
"For this purpose, cells were transfected with HA-14-3-3gamma, and His Ubiquitin, with or without Myc-Usp37 and treated with MG132 before harvesting."
26427597
reach
"In contrast, USP37 remained constant in nocodazole synchronized U2OS cells treated with MG132."
21596315
FOXG1 affects USP37
| 2
FOXG1 inhibits USP37.
| 1
FOXG1 inhibits USP37. 1 / 1
| 1
reach
"Qin et al. illustrated that miR-30b-5p repressed cell proliferation and arrested the cell cycle of a HCC cell line by targeting USP37 [54]."
32128112
FOXG1 activates USP37.
| 1
FOXG1 activates USP37. 1 / 1
| 1
reach
"Qin et al (42) reported that miR-30b-5p inhibited proliferation and slowed cell cycle progression of HCC by targeting DNMT3A and USP37."
33273973
FBXO5 affects USP37
| 1 1
FBXO5 activates USP37. 2 / 2
| 1 1
reach
"Accumulation of APC complex substrate E2F transcription factor targets EMI1, which completely inhibits APC and induces USP37 in the G1 phase (Fig. 1)."
| PMC
eidos
"Accumulation of APC complex substrate E2F transcription factor targets EMI1 , which completely inhibits APC and induces USP37 in the G1 phase ( Fig. 1 ) ."
| PMC
E2F4 affects USP37
2 |
E2F4 decreases the amount of USP37. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Cyclin_E affects USP37
| 2
Cyclin_E phosphorylates USP37 on S628. 1 / 1
| 1
reach
"In G1/S, Ser628 of USP37 is phosphorylated by either CDK2/cyclin E or CDK2/cyclin A, and this triggers USP37 full DUB activity."
32512887
Cyclin_E phosphorylates USP37. 1 / 1
| 1
reach
"Subsequent phosphorylation of USP37 by either CDK2 and cyclin E or CDK2 and cyclin A triggers its full DUB activity."
21596315
Cyclin_A affects USP37
| 2
sparser
"USP37 binds, deubiquitinates, and stabilizes cyclin A, thereby regulating the G1/S transition [ xref ]."
34072267
sparser
"Coimmunoprecipitation experiments indicated an interaction between endogenous USP37 and cyclin A in 293T cells ( Figure 3 C), making cyclin A a potential USP37 substrate."
21596315
Cyclin affects USP37
| 2
Cyclin phosphorylates USP37.
| 1
Cyclin phosphorylates USP37. 1 / 1
| 1
reach
"Subsequent phosphorylation of USP37 by either CDK2 and cyclin E or CDK2 and cyclin A triggers its full DUB activity."
21596315
Cyclin activates USP37.
| 1
Cyclin activates USP37. 1 / 1
| 1
reach
"There is positive reinforcement of this signaling mechanism because phosphorylation of Ser 628 by CDK2 and cyclin E and CDK2 and cyclin A complexes produces maximal USP37 activity, and USP37 activates[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
CDH1 affects APC_C
| 2
APC_C binds CDH1 and USP37. 1 / 1
| 1
sparser
"The core components of APC bind with USP37 through CDH1."
| PMC
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
CDC73 affects USP37
| 1 1
CDC73 binds USP37. 2 / 2
| 1 1
sparser
"The biochemical interaction between the USP37 and CDC73 and their reciprocal binding domains were studied."
35742816
reach
"The biochemical interaction between the USP37 and CDC73 and their reciprocal binding domains were studied."
35742816
CCNA2 affects USP37
2 |
CCNA2 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
21596315
biogrid
No evidence text available
21596315
APC_C affects CDH1
| 2
APC_C binds CDH1 and USP37. 1 / 1
| 1
sparser
"The core components of APC bind with USP37 through CDH1."
| PMC
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
APC CDH1 affects USP37
| 2
APC CDH1 ubiquitinates USP37.
| 1
APC CDH1 ubiquitinates USP37. 1 / 1
| 1
reach
"Further evidence for USP37 deubiquitinating itself is that APC CDH1 could ubiquitinate USP37 in vitro only if the catalytic Cys 350 was mutated or inhibited by ubiquitin-aldehyde."
21596315
APC CDH1 increases the amount of USP37.
| 1
APC CDH1 increases the amount of USP37. 1 / 1
| 1
reach
"We show that USP37 is a DUB that associates with and antagonizes APC CDH1 following E2F mediated USP37 transcription in G1."
21596315
ANAPC7 affects USP37
2 |
ANAPC7 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
21596315
ANAPC5 affects USP37
2 |
ANAPC5 binds USP37. 2 / 2
2 |
biogrid
No evidence text available
26299517
biogrid
No evidence text available
21596315
′-UTR affects USP37
| 1
′-UTR decreases the amount of USP37. 1 / 1
| 1
reach
"Furthermore, the 3′-UTR reporter assay revealed that miR-4487 directly interacts with USP37 and significantly suppresses USP37 expression (right panel of Fig. 4C)."
34352998
Vincristine affects USP37
1 |
Vincristine decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
23649840
Vinclozolin affects USP37
1 |
Vinclozolin increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
23555832
Various affects USP37
| 1
Various activates USP37. 1 / 1
| 1
eidos
"Our TCGA data analysis correlates with observation of various studies that elevated expression of USP37 in different cancers is requisite for cell proliferation and tumorigenesis ."
| PMC
VIRF-2 affects USP37
| 1
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
Ubiquitin E3 affects USP37
| 1
USP37 binds ubiquitin E3. 1 / 1
| 1
reach
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
Tetrachloromethane increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
31150632
Targeting KEN box degron affects USP37
| 1
Targeting KEN box degron inhibits USP37. 1 / 1
| 1
eidos
"B In the late G2 / M phase , USP37 acts as a substrate of the APC / C complex via phosphorylation by PLK1 and is further ubiquitinated by betaTrCP for the biphasic degradation , resulting in the downregulation of USP37 , necessary for the G2 / M phase transition Interestingly , the APC-CDH1 complex degrades USP37 in late mitosis by targeting its KEN box degron ."
| PMC
Succimer affects USP37
1 |
Succimer decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
26378955
SiRNA#2 and siRNA#3.The affects USP37
| 1
SiRNA#2 and siRNA#3.The decreases the amount of USP37. 1 / 1
| 1
reach
"These results confirmed that USP37 gene expression could be effectively downregulated by siRNA#2 and siRNA#3.The expression of USP37 gene has been demonstrated to be elevated in patients with a recurrence of cancer, indicating that USP37 levels may be closely related to breast cancer distant metastasis [16]."
30482232
Polyubiquitin affects USP37
| 1
USP37 binds polyubiquitin. 1 / 1
| 1
reach
"We show that the deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A. USP37 was induced by E2F transcription factors in G1, peaked at G1/S, and was degraded in late mitosis."
21596315
Mono(2-ethylhexyl) phthalate decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
31059758
MiR-4487 affects USP37
| 1
MiR-4487 decreases the amount of USP37. 1 / 1
| 1
reach
"Furthermore, the 3′-UTR reporter assay revealed that miR-4487 directly interacts with USP37 and significantly suppresses USP37 expression (right panel of Fig. 4C)."
34352998
MiR-30b-5p affects USP37
| 1
MiR-30b-5p activates USP37. 1 / 1
| 1
reach
"Qin et al (42) reported that miR-30b-5p inhibited proliferation and slowed cell cycle progression of HCC by targeting DNMT3A and USP37."
33273973
Methyl methanesulfonate increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
23649840
Mechanisms include affects USP37
| 1
Mechanisms include inhibits USP37. 1 / 1
| 1
eidos
"In addition , the G9a inhibitor UNC0638 impairs proliferation of human DAOY MB cells and MB growth in vivo through mechanisms that include downregulating USP37 [ 59,60 ] ."
| PMC
Magnetite nanoparticle decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
26378955
Jinfukang affects USP37
1 |
Jinfukang decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
27392435
Hsa-miR-891a-5p affects USP37
1 |
Hsa-miR-891a-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6833-3p affects USP37
1 |
Hsa-miR-6833-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6828-5p affects USP37
1 |
Hsa-miR-6828-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6820-3p affects USP37
1 |
Hsa-miR-6820-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-6809-3p affects USP37
1 |
Hsa-miR-6809-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-616-3p affects USP37
1 |
Hsa-miR-616-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-5580-5p affects USP37
1 |
Hsa-miR-5580-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-548av-3p affects USP37
1 |
Hsa-miR-548av-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-5003-3p affects USP37
1 |
Hsa-miR-5003-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4775 affects USP37
1 |
Hsa-miR-4775 decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4768-5p affects USP37
1 |
Hsa-miR-4768-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4753-3p affects USP37
1 |
Hsa-miR-4753-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-455-3p affects USP37
1 |
Hsa-miR-455-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4501 affects USP37
1 |
Hsa-miR-4501 decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-4487 affects USP37
1 |
Hsa-miR-4487 decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4280 affects USP37
1 |
Hsa-miR-4280 decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4264 affects USP37
1 |
Hsa-miR-4264 decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-3591-5p affects USP37
1 |
Hsa-miR-3591-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-32-3p affects USP37
1 |
Hsa-miR-32-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3164 affects USP37
1 |
Hsa-miR-3164 decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-3118 affects USP37
1 |
Hsa-miR-3118 decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-30e-5p affects USP37
1 |
Hsa-miR-30e-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-30b-5p affects USP37
1 |
Hsa-miR-30b-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-30a-5p affects USP37
1 |
Hsa-miR-30a-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-302d-5p affects USP37
1 |
Hsa-miR-302d-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-302b-5p affects USP37
1 |
Hsa-miR-302b-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-215-3p affects USP37
1 |
Hsa-miR-215-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-1910-5p affects USP37
1 |
Hsa-miR-1910-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-191-5p affects USP37
1 |
Hsa-miR-191-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-185-3p affects USP37
1 |
Hsa-miR-185-3p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-130b-5p affects USP37
1 |
Hsa-miR-130b-5p decreases the amount of USP37. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hexabromocyclododecane decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
29177809
Haloperidol affects USP37
1 |
Haloperidol increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
29458080
Genistein affects USP37
1 |
Genistein increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
24552547
Ethyl methanesulfonate increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
23649840
Dorsomorphin affects USP37
1 |
Dorsomorphin increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
30157643
Diisobutyl phthalate decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
29458080
Chlordecone affects USP37
1 |
Chlordecone increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
29458080
Bleomycin A5 affects USP37
1 |
Bleomycin A5 decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
21040473
Aflatoxin B1 affects USP37
1 |
Aflatoxin B1 demethylates USP37. 1 / 1
1 |
ctd
No evidence text available
27153756
ZEB1 affects USP37
1 |
ZEB1 decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
WRNIP1 affects USP37
1 |
USP37 binds WRNIP1. 1 / 1
1 |
biogrid
No evidence text available
26299517
WDR82 affects USP37
1 |
USP37 binds WDR82. 1 / 1
1 |
biogrid
No evidence text available
26299517
WDHD1 affects USP37
1 |
USP37 binds WDHD1. 1 / 1
1 |
biogrid
No evidence text available
26299517
WAPL affects Cohesin
| 1
Cohesin binds USP37 and WAPL. 1 / 1
| 1
sparser
"The authors further demonstrated that USP37 interacts with both cohesin and a negative regulator WAPL, which is required for releasing cohesin from chromatid arms in prophase."
32201366
Ub-binding site affects USP37
| 1
USP37 binds Ub-binding site. 1 / 1
| 1
reach
"This result is consistent with the likelihood that UbV.core directly competed for binding to the distal Ub binding site of USP37."
30858488
USP37 affects γ-H2AX foci
| 1
USP37 inhibits γ-H2AX foci. 1 / 1
| 1
reach
"Furthermore, as shown in Supplementary Figure S4A–C, depletion of USP37 increased retention of γ-H2AX foci at at late time points in response to IR in control but not BLM knockdown cells."
34606619
USP37 affects wild-type Snail1
| 1
USP37 increases the amount of wild-type Snail1. 1 / 1
| 1
reach
"As shown in Figure XREF_FIG E, USP37 remarkably elevated the protein level of wild-type Snail1 but had no significant impact on Snail1-6SA."
33391500
USP37 affects vIRF-2
| 1
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
USP37 affects ubiquitin E3
| 1
USP37 binds ubiquitin E3. 1 / 1
| 1
reach
"HBx acts as a chaperone of USP37 and shuttles it out of the nucleus, where the ubiquitin E3 ligase CDC20 homolog 1 (CDH1) and b-TrCP associate with USP37 (Zhou et al., 2003; von Mikecz, 2006; Saxena and Kumar, 2014)."
30510918
USP37 affects tumorigenicity MCF-7
| 1
USP37 activates tumorigenicity MCF-7. 1 / 1
| 1
eidos
"Furthermore , in vivo study showed that knockdown of USP37 expression also decreased tumorigenicity of MCF-7 / ADR cells in mice ."
33390801
USP37 affects tumorigenesis lung cancer
| 1
USP37 activates tumorigenesis lung cancer. 1 / 1
| 1
eidos
"Thus , we hypothesized that USP37 may contribute to the tumorigenesis of lung cancer by regulating CDT1 ."
33898105
USP37 affects tumor growth
| 1
USP37 activates tumor growth. 1 / 1
| 1
eidos
"Moreover , the DUB USP7 , USP13 , USP22 , USP28 , USP36 and USP37 stabilize c-Myc , thereby stimulating tumor growth [ 155 , 157 , 171-174 ] ."
| PMC
USP37 affects tumor MCF-7 ADR cells
| 1
USP37 activates tumor MCF-7 ADR cells. 1 / 1
| 1
eidos
"USP37 knockdown inhibits the tumor formation of MCF-7 / ADR cells in vivo The above results indicated that USP37 gene was overexpressed in adriamycin-resistant breast cancer cells and its downregulation could inhibit cell growth ."
33390801
USP37 affects stemness cell invasion EMT breast cancer
| 1
USP37 activates stemness cell invasion EMT breast cancer. 1 / 1
| 1
eidos
"Further studies indicated that USP37 knockdown could inhibit the stemness , cell invasion and EMT in breast cancer via downregulation of Hh pathway ."
30482232
USP37 affects stability Gli-1 protein cells
| 1
USP37 activates stability Gli-1 protein cells. 1 / 1
| 1
eidos
"Furthermore , knockdown of USP37 expression significantly decreased the stability of Gli-1 protein both in MCF-7 and MDA-MB-231 cells ( Fig. 7d and e ) ."
30482232
USP37 affects spheroids
| 1
USP37 activates spheroids. 1 / 1
| 1
eidos
"In addition , USP37 knockdown significantly inhibited the formation of spheroids , as well as their size and volume , compared to the control cells in MCF-7 and MDA-MB-231 cells ( Fig. 4c and d ) ."
30482232
USP37 affects spheroid
| 1
USP37 inhibits spheroid. 1 / 1
| 1
eidos
"Furthermore , USP37 was also elevated at the protein level in cancer stem cell spheroids compared to adherent cells , and its knockdown ( KD ) decreased expression of stem cell markers like smoothened , Gli-1 , ALDH1 , and OCT4 and inhibited stable spheroid formation ."
| PMC
reach
"These findings are further supported by the ability of USP37 to participate in Hh signaling pathway in breast cancer."
30482232
USP37 affects sensitivity cisplatin
| 1
USP37 inhibits sensitivity cisplatin. 1 / 1
| 1
eidos
"USP37 knockdown inhibits tumorigenicity and increases sensitivity to cisplatin in vivo ."
30482232
USP37 affects response to drug
| 1
USP37 activates response to drug. 1 / 1
| 1
reach
"These findings provide early evidence that USP37 modulates drug resistance."
| PMC
USP37 affects resistance breast cancer cells adriamycin
| 1
USP37 activates resistance breast cancer cells adriamycin. 1 / 1
| 1
eidos
"Conclusion : Knockdown of USP37 gene expression can reverse the resistance of breast cancer cells to adriamycin , and down-regulating USP37 might be a valuable strategy against ADR resistance in breast cancer therapy ."
33390801
USP37 affects proteolysis
| 1
USP37 inhibits proteolysis. 1 / 1
| 1
eidos
"Moreover , knockdown of USP37 increases BLM polyubiquitination , accelerates its proteolysis , and impairs its function in DNA damage response ."
34606619
USP37 affects protein folding
| 1
USP37 activates protein folding. 1 / 1
| 1
reach
"Additionally, it is important to note that the introduction of a conserved cysteine residue in USP37 may have caused a change in protein folding and promoted its inactivation."
22665064
USP37 affects protein Smo Gli-1
| 1
USP37 activates protein Smo Gli-1. 1 / 1
| 1
eidos
"Upregulation of USP37 could enhance protein expression levels of Smo and Gli-1 ."
30482232
USP37 affects proteasomal CDT1
| 1
USP37 inhibits proteasomal CDT1. 1 / 1
| 1
eidos
"To explore whether USP37 mediates the proteasomal degradation of CDT1 , we treated USP37-silencing cells with MG132 or dimethyl sulfoxide ( DMSO ) and detected the expression of CDT1 afterward ."
33898105
USP37 affects primary kidney tumorigenesis
| 1
USP37 activates primary kidney tumorigenesis. 1 / 1
| 1
eidos
"This was further validated in an orthotopic mouse model in which USP37 depletion reduces primary kidney tumorigenesis and decreases lung metastasis ."
| PMC
USP37 affects polyubiquitination
| 1
USP37 inhibits polyubiquitination. 1 / 1
| 1
eidos
"Moreover , knockdown of USP37 increases BLM polyubiquitination , accelerates its proteolysis , and impairs its function in DNA damage response ."
34606619
USP37 affects polyubiquitination protein
| 1
USP37 activates polyubiquitination protein. 1 / 1
| 1
eidos
"Subsequent sub-screening identified 23 DUBs that interact with SNAI1 , out of which USP29 , USP36 , and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein ."
| PMC
USP37 affects polyubiquitin
| 1
USP37 binds polyubiquitin. 1 / 1
| 1
reach
"We show that the deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A. USP37 was induced by E2F transcription factors in G1, peaked at G1/S, and was degraded in late mitosis."
21596315
USP37 affects oncogenic fusion protein PLZF RARA stability cell transformation potential
| 1
USP37 activates oncogenic fusion protein PLZF RARA stability cell transformation potential. 1 / 1
| 1
eidos
"Subsequently , it was verified that USP37 expression modulated the oncogenic fusion protein PLZF / RARA stability and cell transformation potential in PLZF / RARA-associated acute promyelocytic leukemia [ 33 ] ."
30482232
USP37 affects oncogenic fusion PLZF-RARA
| 1
USP37 deubiquitinates oncogenic fusion PLZF-RARA. 1 / 1
| 1
reach
"Lastly, USP37 deubiquitinates and stabilizes the proto-oncogene c-Myc and the oncogenic fusion PLZF-RARA, suggesting that inhibition of USP37 DUB activity could have therapeutic potential XREF_BIBR, XREF_BIBR."
30858488
USP37 affects mesenchymal-epithelial transition MET process breast cancer cell lines
| 1
USP37 inhibits mesenchymal-epithelial transition MET process breast cancer cell lines. 1 / 1
| 1
eidos
"These results indicated that downregulation of USP37 induced the mesenchymal-epithelial transition ( MET ) process in breast cancer cell lines ."
30482232
reach
"A study by Qin et al. reported that USP37 KD suppresses BC and BC stem cell migration and invasion by promoting the mesenchymal-epithelial transition (MET) by markedly reducing the SNAI1, N-cadherin, and vimentin expression and increasing the E-cadherin."
| PMC
USP37 affects mammospheres
| 1
USP37 activates mammospheres. 1 / 1
| 1
eidos
"Knockdown of USP37 suppressed mammospheres formation and inhibited cancer stem markers , such as ALDH1and OCT4 in breast cancer cells ."
30482232
USP37 affects malignant
| 1
USP37 activates malignant. 1 / 1
| 1
eidos
"As is the case with USP2 , it remains unknown if USP37 is upregulated or activated in cancer to promote malignant progression , or if targeting USP37 could be therapeutically beneficial in cancer ."
32201366
USP37 affects lung cancer cell
| 1
USP37 activates lung cancer cell. 1 / 1
| 1
eidos
"Accumulating evidence has demonstrated that USP37 promotes lung cancer cell proliferation , migration , and invasion16 but inhibits lung cancer cell apoptosis in a deubiquitination-dependent manner.19 Therefore , it is possible that IH-mediated miR-320b reduction in lung cancer cells resulted in the upregulation of USP37 , which further promoted cancer cell proliferation , invasion , and survival ."
33898105
USP37 affects lung cancer cell apoptosis
| 1
USP37 inhibits lung cancer cell apoptosis. 1 / 1
| 1
eidos
"Accumulating evidence has demonstrated that USP37 promotes lung cancer cell proliferation , migration , and invasion16 but inhibits lung cancer cell apoptosis in a deubiquitination-dependent manner.19 Therefore , it is possible that IH-mediated miR-320b reduction in lung cancer cells resulted in the upregulation of USP37 , which further promoted cancer cell proliferation , invasion , and survival ."
33898105
USP37 affects invasion migration breast cancer cells
| 1
USP37 activates invasion migration breast cancer cells. 1 / 1
| 1
eidos
"Furthermore , upregulation of USP37 markedly promoted invasion and migration of breast cancer cells ( Fig. 3k and l ) ."
30482232
USP37 affects invading capacity MCF-7 MDA-MB-231 cells
| 1
USP37 activates invading capacity MCF-7 MDA-MB-231 cells. 1 / 1
| 1
eidos
"The transwell assay revealed that downregulation of USP37 obviously decreased the invading capacity of MCF-7 and MDA-MB-231 cells ."
30482232
USP37 affects intrinsic apoptosis including Bcl-2
| 1
USP37 inhibits intrinsic apoptosis including Bcl-2. 1 / 1
| 1
eidos
"More significantly , knockdown of USP37 will impair the adriamycin resistance of breast cancer cells and induce intrinsic apoptosis , including Bcl-2 / Bax / cleaved caspase 3 ."
33390801
USP37 affects inhibitory adriamycin MCF-7 MCF-7
| 1
USP37 inhibits inhibitory adriamycin MCF-7 MCF-7. 1 / 1
| 1
eidos
"Our data demonstrated that USP37 downregulation enhanced the inhibitory effect of adriamycin on MCF-7 and MCF-7 / ADR cancer cells through the inhibition of Bcl-2 / Bax signaling pathway ."
33390801
USP37 affects helicase
| 1
USP37 activates helicase. 1 / 1
| 1
reach
"Notably, Cdt1 ubiquitination can be reversed through the function of the ubiquitin hydrolase USP37, whose activity stabilizes Cdt1 and promotes helicase loading."
28094588
USP37 affects hedgehog Hh pathway components Smo
| 1
USP37 activates hedgehog Hh pathway components Smo. 1 / 1
| 1
eidos
"Knockdown of USP37 significantly decreased hedgehog ( Hh ) pathway components Smo and Gli-1 ."
30482232
USP37 affects growth experimental MB
| 1
USP37 inhibits growth experimental MB. 1 / 1
| 1
eidos
"Expression of USP37 is downregulated in human MB , and USP37 reduces the growth of experimental MB ."
| PMC
USP37 affects function response
| 1
USP37 activates function response. 1 / 1
| 1
eidos
"Moreover , knockdown of USP37 increases BLM polyubiquitination , accelerates its proteolysis , and impairs its function in DNA damage response ."
34606619
USP37 affects entry
| 1
USP37 activates entry. 1 / 1
| 1
eidos
"Mechanistically , they found that USP37 counteracts APC / C-mediated ubiquitination of cyclin A , and that USP37 itself is phosphorylated by cyclin A-Cdk2 to increase its DUB activity and allow S-phase entry ."
32201366
USP37 affects drug sensitivity cisplatin
| 1
USP37 activates drug sensitivity cisplatin. 1 / 1
| 1
eidos
"Knockdown of USP37 expression hampered cell invasion , stemness , EMT and also resulted in the drug sensitivity to cisplatin ."
30482232
USP37 affects disorder cell cycle
| 1
USP37 inhibits disorder cell cycle. 1 / 1
| 1
eidos
"The current finding showed that USP37 downregulation leads to disorder of cell cycle during G1 and G1 / S phases of the cell cycle 22 , which confirmed our data that USP37 knockdown altered the cell cycle by increasing the accumulation of the G0 / G1 phase and reducing the cell population in S phase ."
33390801
USP37 affects deubiquitination-dependent manner.19
| 1
USP37 inhibits deubiquitination-dependent manner.19. 1 / 1
| 1
eidos
"Accumulating evidence has demonstrated that USP37 promotes lung cancer cell proliferation , migration , and invasion16 but inhibits lung cancer cell apoptosis in a deubiquitination-dependent manner.19 Therefore , it is possible that IH-mediated miR-320b reduction in lung cancer cells resulted in the upregulation of USP37 , which further promoted cancer cell proliferation , invasion , and survival ."
33898105
USP37 affects deubiquitination HIF2alpha kidney cancer
| 1
USP37 activates deubiquitination HIF2alpha kidney cancer. 1 / 1
| 1
eidos
"USP37 promotes deubiquitination of HIF2alpha in kidney cancer ."
32461361
USP37 affects deubiquitination CDT1
| 1
USP37 activates deubiquitination CDT1. 1 / 1
| 1
eidos
"USP37 induces deubiquitination of CDT1 , whereas a catalytically inactive ( C350S ) USP37 mutant is unable to ubiquitinate CDT1 , further suggesting that USP37 plays a role in CDT1 stabilization ."
| PMC
USP37 affects complex assembly
| 1
USP37 inhibits complex assembly. 1 / 1
| 1
reach
"These data suggest that USP26 and USP37 limit the magnitude of BRCA1-A complex assembly in DSB neighboring chromatin by counteracting RNF168 mediated H2A ubiquitylation."
26101254
USP37 activates chromosome segregation. 1 / 1
| 1
reach
"Therefore, in addition to a role in sister chromatid resolution, both USP37 and WAPL contribute to normal chromosome segregation and bioriented kinetochore-microtubule attachment.Given these similar p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
USP37 affects chromosomal segregation
| 1
USP37 activates chromosomal segregation. 1 / 1
| 1
eidos
"Additionally , identifying faulty kinetochore-microtubule attachments by error correction assay indicated that both USP37 and WAPL contribute to chromosomal segregation and bioriented kinetochore-microtubule attachment ."
| PMC
USP37 affects chemoresistance breast cancer cells
| 1
USP37 activates chemoresistance breast cancer cells. 1 / 1
| 1
eidos
"These results demonstrated that USP37 knockdown could reduce the chemoresistance of breast cancer cells against adriamycin ."
33390801
USP37 affects chemical resistance MCF-7 MCF-7
| 1
USP37 activates chemical resistance MCF-7 MCF-7. 1 / 1
| 1
eidos
"In this study , we investigated whether USP37 knockdown could hamper the chemical resistance of MCF-7 and MCF-7 / ADR cells to adriamycin and elucidated the potential mechanism ."
33390801
USP37 affects cellular
| 1
USP37 activates cellular. 1 / 1
| 1
eidos
"Knockdown of USP37 tremendously inhibited cellular proliferation as shown in Figure 3A ."
33390801
USP37 affects cellular breast cancer cells
| 1
USP37 activates cellular breast cancer cells. 1 / 1
| 1
eidos
"Through knockdown of USP37 expression in breast cancer MCF-7 cells and MCF-7 / ADR cells with a lentivirus vector system , we demonstrated that USP37 downregulation can evidently inhibit cellular proliferation of breast cancer cells ."
33390801
USP37 affects cell migration invasion breast cancer cells
| 1
USP37 activates cell migration invasion breast cancer cells. 1 / 1
| 1
eidos
"Moreover , we found that knockdown of USP37 suppressed cell migration and invasion in breast cancer cells ."
30482232
USP37 affects cell migration capacity
| 1
USP37 activates cell migration capacity. 1 / 1
| 1
eidos
"Knockdown of USP37 evidently inhibited cell migration capacity in both MCF and MDA-MB-231 cells ( Fig. 3f , g ) ."
30482232
USP37 affects cell growth
| 1
USP37 inhibits cell growth. 1 / 1
| 1
reach
"Thus, we examined whether knock-down of USP37 decreased cancer cell growth by downregulation of 14-3-3gamma."
26427597
reach
"Since concomitant loss of REST and USP37 expression attenuated p27 stabilization and differentiation and rescued cell proliferation, our data strongly suggest that repression of USP37 and consequent p27 degradation, are important for REST dependent maintenance of cell proliferation."
22665064
USP37 affects cancer stem markers
| 1
USP37 activates cancer stem markers. 1 / 1
| 1
eidos
"Knockdown of USP37 suppressed mammospheres formation and inhibited cancer stem markers , such as ALDH1and OCT4 in breast cancer cells ."
30482232
USP37 affects c-Myc recycling lung cancer
| 1
USP37 inhibits c-Myc recycling lung cancer. 1 / 1
| 1
eidos
"Moreover , USP37 induces c-Myc activity by suppressing its degradation , while the inhibition of USP37 increases c-Myc recycling in lung cancer [ 80 ] ."
| PMC
USP37 affects breast cancer stem-like properties
| 1
USP37 activates breast cancer stem-like properties. 1 / 1
| 1
eidos
"These data confirm that USP37 mediates breast cancer stem-like properties , cell invasion and EMT via the Hh pathway ."
30482232
USP37 affects bioriented kinetochore-microtubule attachment
| 1
USP37 activates bioriented kinetochore-microtubule attachment. 1 / 1
| 1
eidos
"Additionally , identifying faulty kinetochore-microtubule attachments by error correction assay indicated that both USP37 and WAPL contribute to chromosomal segregation and bioriented kinetochore-microtubule attachment ."
| PMC
USP37 affects apoptosis investigate latent USP37 transformation breast cancer cells
| 1
USP37 inhibits apoptosis investigate latent USP37 transformation breast cancer cells. 1 / 1
| 1
eidos
"Knockdown of USP37 inhibits cell proliferation and induces apoptosis To investigate the latent role of USP37 gene in the transformation of breast cancer cells , cell proliferation was examined by CCK-8 assay ."
33390801
USP37 affects adriamycin resistance breast cancer cells
| 1
USP37 activates adriamycin resistance breast cancer cells. 1 / 1
| 1
eidos
"More significantly , knockdown of USP37 will impair the adriamycin resistance of breast cancer cells and induce intrinsic apoptosis , including Bcl-2 / Bax / cleaved caspase 3 ."
33390801
USP37 affects activation Hh pathway
| 1
USP37 activates activation Hh pathway. 1 / 1
| 1
eidos
"Therefore , it is a promising research to investigate whether USP37 promoted the activation of the Hh pathway ."
30482232
USP37 affects WRNIP1
1 |
USP37 binds WRNIP1. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects WDR82
1 |
USP37 binds WDR82. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects WDHD1
1 |
USP37 binds WDHD1. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects VIM
| 1
USP37 increases the amount of VIM. 1 / 1
| 1
reach
"As shown in Fig. 3c and d, knockdown of USP37 significantly decreased Snail1, N-cadherin and Vimentin expression, but increased E-cadherin expression levels."
30482232
USP37 affects Ub-binding site
| 1
USP37 binds Ub-binding site. 1 / 1
| 1
reach
"This result is consistent with the likelihood that UbV.core directly competed for binding to the distal Ub binding site of USP37."
30858488
USP37 affects TUBA1A
1 |
USP37 binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects TRIM4
1 |
TRIM4 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects TASOR
1 |
USP37 binds TASOR. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects TAF9B
1 |
TAF9B binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects TAF6
1 |
TAF6 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects TAF1
1 |
TAF1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects Snail1 N-cadherin Vimentin
| 1
USP37 activates Snail1 N-cadherin Vimentin. 1 / 1
| 1
eidos
"As shown in Fig. 3c and d , knockdown of USP37 significantly decreased Snail1 , N-cadherin and Vimentin expression , but increased E-cadherin expression levels ."
30482232
USP37 affects STAG1
1 |
STAG1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects SPEN
1 |
SPEN binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects SNU13
1 |
USP37 binds SNU13. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects SNRNP40
1 |
USP37 binds SNRNP40. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects SMC1A
1 |
SMC1A binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects SMC1
| 1
Cohesin binds SMC1, USP37, and SMC3. 1 / 1
| 1
sparser
"Identifying USP37-interacting partners with proximity-dependent biotin identification (BioID) found that USP37 interacts with the cohesin complex proteins SMC3, SMC1, SSCC1, and SA1/2, as well with the regulators of cohesion WAPL and NIPBL [ xref ]."
| PMC
USP37 affects SIRT1
1 |
SIRT1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects SF3B5
1 |
USP37 binds SF3B5. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects SAP18
1 |
SAP18 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects S phases cell cycle
| 1
USP37 inhibits S phases cell cycle. 1 / 1
| 1
eidos
"The current finding showed that USP37 downregulation leads to disorder of cell cycle during G1 and G1 / S phases of the cell cycle 22 , which confirmed our data that USP37 knockdown altered the cell cycle by increasing the accumulation of the G0 / G1 phase and reducing the cell population in S phase ."
33390801
USP37 affects RPA3
1 |
RPA3 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects RPA2
1 |
RPA2 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects RNF8/168
| 1
USP37 inhibits RNF8/168. 1 / 1
| 1
reach
"Given that USP26 and USP37 are able to reverse RNF8/168 mediated ubiquitylation and promote HR, these enzymes would be ideal candidates to facilitate the repositioning of ubiquitylated substrates away from the DSB."
26101254
USP37 affects PRIM2
1 |
USP37 binds PRIM2. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects PPP1CB
1 |
USP37 binds PPP1CB. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects POLR2H
1 |
USP37 binds POLR2H. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects POGZ
1 |
POGZ binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects PNN
1 |
USP37 binds PNN. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects PM EMT markers
| 1
USP37 activates PM EMT markers. 1 / 1
| 1
eidos
"Meanwhile , knockdown of USP37 reversed the effect of PM on the EMT markers ."
30482232
USP37 affects PHF2
1 |
USP37 binds PHF2. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects PAXBP1
1 |
PAXBP1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects NIPBL
1 |
USP37 binds NIPBL. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects MTREX
1 |
MTREX binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects MIS18A
1 |
MIS18A binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects MCM4
1 |
USP37 binds MCM4. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects MCF-7 ADR cancer cells
| 1
USP37 inhibits MCF-7 ADR cancer cells. 1 / 1
| 1
eidos
"Our data demonstrated that USP37 downregulation enhanced the inhibitory effect of adriamycin on MCF-7 and MCF-7 / ADR cancer cells through the inhibition of Bcl-2 / Bax signaling pathway ."
33390801
USP37 affects MAX
1 |
USP37 binds MAX. 1 / 1
1 |
biogrid
No evidence text available
25284584
USP37 affects LC3B
| 1
USP37 inhibits LC3B. 1 / 1
| 1
reach
"Moreover, deletion of USP37 and treatment of gefitinib was confirmed to increase LC3B cleavage respectively."
34352998
USP37 affects KRT84
1 |
USP37 binds KRT84. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP37 affects K11
| 1
USP37 binds C-Cdh1 and K11. 1 / 1
| 1
reach
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing - for example, the DUB USP37 interacts with APC and C-Cdh 1 to modulate K11 linkages on at least one substrate."
26835416
USP37 affects Ile-His
| 1
USP37 inhibits Ile-His. 1 / 1
| 1
reach
"However, co-transfecting miR-320b mimic and USP37 failed to inhibit IH induced lung cancer cell invasion (XREF_FIG D and XREF_SUPPLEMENTARY B), indicating that miR-320b inhibited 6IH induced invasion in a USP37 dependent manner."
33898105
USP37 affects IPO9
1 |
IPO9 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects INTS12
1 |
USP37 binds INTS12. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects IFI27
1 |
USP37 deubiquitinates IFI27. 1 / 1
1 |
ubibrowser
"Ectopically expressed wild-type USP37 formed a complex with p27, promoted its deubiquitination and stabilization and blocked cell proliferation."
22665064
USP37 affects Hh targets Smo Gli-1 cell marker Ki-67 tumor tissues
| 1
USP37 activates Hh targets Smo Gli-1 cell marker Ki-67 tumor tissues. 1 / 1
| 1
eidos
"We found that lower expression level of USP37 obviously impaired the expression of Hh targets ( Smo and Gli-1 ) and cell proliferation marker Ki-67 in the tumor tissues as seen by immunohistochemical staining ( Fig. 8e ) ."
30482232
USP37 affects Hemagglutinins
| 1
USP37 binds MYC, Hemagglutinins, and 14-3-3γ. 1 / 1
| 1
sparser
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3γ and Myc-USP37."
26427597
USP37 affects HNRNPC
1 |
USP37 binds HNRNPC. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects HNRNPA3
1 |
USP37 binds HNRNPA3. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects HIF2alpha protein stability
| 1
USP37 activates HIF2alpha protein stability. 1 / 1
| 1
eidos
"As a result , USP37 promotes HIF2alpha protein stability in an enzymatically dependent manner , and depletion of USP37 leads to HIF2alpha down-regulation in ccRCC ."
32461361
USP37 affects HIF2alpha ccRCC
| 1
USP37 activates HIF2alpha ccRCC. 1 / 1
| 1
eidos
"As a result , USP37 promotes HIF2alpha protein stability in an enzymatically dependent manner , and depletion of USP37 leads to HIF2alpha down-regulation in ccRCC ."
32461361
USP37 affects HDAC2
1 |
USP37 binds HDAC2. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects HDAC1
1 |
USP37 binds HDAC1. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects HA-14-3-3gamma
| 1
USP37 binds HA-14-3-3gamma. 1 / 1
| 1
reach
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3gamma and Myc-USP37."
26427597
USP37 affects H2AZ1
1 |
USP37 binds H2AZ1. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects GTF3C3
1 |
USP37 binds GTF3C3. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects G1
| 1
USP37 binds APC/C Cdh1 and G1. 1 / 1
| 1
reach
"Usp37 binds APC/C Cdh1 in G1 and deubiquitinates the APC/C substrate cyclin A [XREF_BIBR]."
21978762
USP37 affects FBXW7
| 1
USP37 deubiquitinates FBXW7. 1 / 1
| 1
reach
"An early study showed that USP28 deubiquitinates c-Myc via interacting with Fbw7alpha whereas a recent study reveals that USP37 deubiquitinates c-Myc independently of Fbw7 and c-Myc phosphorylation."
26697836
USP37 affects EXOSC9
1 |
USP37 binds EXOSC9. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects ESR1
| 1
USP37 binds ESR1. 1 / 1
| 1
sparser
"Further mechanistic study revealed the interaction between USP37 and ERα: USP37 regulated ERα signaling through modulating protein stability instead of gene expression, in which it stabilized ERα protein via inhibiting the K48-specific poly-ubiquitination process."
36221793
USP37 affects EGFR
| 1
USP37 inhibits EGFR. 1 / 1
| 1
reach
"miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non-Small Cell Lung Cancer Cells by Targeting USP37."
34352998
USP37 affects ECH1
1 |
USP37 binds ECH1. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects E3_Ub_ligase
| 1
sparser
"Mutations in UIM2 and UIM3 abrogate binding to K48- and K63-linked Ub 4 chains, similar to published work [ 16 ], but also to K11-linked Ub 4 chains, which are produced by APC CDH1 , the E3 ligase a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
USP37 affects Drug Resistance
| 1
USP37 activates Drug Resistance. 1 / 1
| 1
eidos
"These findings provide early evidence that USP37 modulates drug resistance ."
| PMC
USP37 affects Deubiquitinase
| 1
USP37 activates Deubiquitinase. 1 / 1
| 1
eidos
"Mechanistically , they found that USP37 counteracts APC / C-mediated ubiquitination of cyclin A , and that USP37 itself is phosphorylated by cyclin A-Cdk2 to increase its DUB activity and allow S-phase entry ."
32201366
USP37 affects DSB repair
| 1
USP37 activates DSB repair. 1 / 1
| 1
reach
"Loss of USP26 or USP37 impairs DSB repair."
26101254
USP37 affects DPY30
1 |
USP37 binds DPY30. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects DNA replication
| 1
reach
"In addition, downregulation of USP37 reduces DNA replication fork speed."
27296872
USP37 activates DNA damage response, detection of DNA damage. 1 / 1
| 1
reach
"Knockdown of USP37 impairs the DDR through BLM and results in increased sensitivity to cisplatin or IR treatment in breast cancer cells."
34606619
USP37 affects DHX15
1 |
USP37 binds DHX15. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects Chemical Sensitivity Human Breast Cancer Cells
| 1
USP37 inhibits Chemical Sensitivity Human Breast Cancer Cells. 1 / 1
| 1
eidos
"USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin Background : The evolution of adriamycin ( ADR ) resistance in the treatment of breast cancer often leads to a poor prognosis in patients ."
33390801
USP37 affects CUL1
1 |
USP37 binds CUL1. 1 / 1
1 |
biogrid
No evidence text available
23027877
USP37 affects CHERP
1 |
CHERP binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects CHEK1
| 1
USP37 deubiquitinates CHEK1. 1 / 1
| 1
reach
"We further demonstrated that USP37 deubiquitinates CHK1, promoting its stability."
34509474
USP37 affects CHD8
1 |
USP37 binds CHD8. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects CDT1 protein
| 1
USP37 activates CDT1 protein. 1 / 1
| 1
eidos
"The results illustrated that USP37 knockdown significantly reduced CDT1 protein levels while lysosomal inhibitor ( MG132 ) preserved the CDT1 protein ( Figure 5M ) ."
33898105
USP37 affects CDT1 deubiquitination miR-320b IH-mediated lung cancer
| 1
USP37 inhibits CDT1 deubiquitination miR-320b IH-mediated lung cancer. 1 / 1
| 1
eidos
"USP37 promotes the expression of CDT1 by deubiquitination miR-320b impaired IH-mediated lung cancer progression by inhibiting CDT1 expression through targeting USP37 To understand whether the regulation of CDT1 expression by USP37 plays a role in lung cancer cell growth and invasion , the expressions of miR-320b and / or CDT1 in lung cancer cells ( A549 and H1650 ) were altered ."
33898105
USP37 affects CDC23
1 |
CDC23 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects CDC16
1 |
CDC16 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects CCP110
| 1
USP37 leads to the deubiquitination of CCP110. 1 / 1
| 1
reach
"In addition, over-expression of two unrelated DUBs, USP1 and USP37, did not promote CP110 de-ubiquitylation (XREF_FIG and data not shown)."
23486064
USP37 affects CBX3
1 |
CBX3 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects C-Cdh1
| 1
USP37 binds C-Cdh1 and K11. 1 / 1
| 1
reach
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing - for example, the DUB USP37 interacts with APC and C-Cdh 1 to modulate K11 linkages on at least one substrate."
26835416
USP37 affects Breast Neoplasms
| 1
USP37 activates Breast Neoplasms. 1 / 1
| 1
eidos
"These results indicated that USP37 downregulation attenuates breast cancer progression and enhances sensitivity to cisplatin in vivo ."
30482232
USP37 affects BRIP1
1 |
USP37 binds BRIP1. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects BRCA1-A
| 1
USP37 inhibits BRCA1-A. 1 / 1
| 1
reach
"These data suggest that USP26 and USP37 limit the magnitude of BRCA1-A complex assembly in DSB neighboring chromatin by counteracting RNF168 mediated H2A ubiquitylation."
26101254
USP37 affects BC
| 1
USP37 inhibits BC. 1 / 1
| 1
reach
"A study by Qin et al. reported that USP37 KD suppresses BC and BC stem cell migration and invasion by promoting the mesenchymal-epithelial transition (MET) by markedly reducing the SNAI1, N-cadherin, and vimentin expression and increasing the E-cadherin."
| PMC
USP37 affects BAX
| 1
USP37 activates BAX. 1 / 1
| 1
reach
"USP37 KD in MCF7 cells also increased sensitivity to chemotherapeutic agents such as cisplatin by decreasing the BCL2/BAX ratio and attenuating tumor growth in vivo [39]."
| PMC
USP37 affects APC/C Cdh1
| 1
USP37 binds APC/C Cdh1 and G1. 1 / 1
| 1
reach
"Usp37 binds APC/C Cdh1 in G1 and deubiquitinates the APC/C substrate cyclin A [XREF_BIBR]."
21978762
USP37 affects ANAPC16
1 |
USP37 binds ANAPC16. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects ANAPC15
1 |
USP37 binds ANAPC15. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects ANAPC13
1 |
USP37 binds ANAPC13. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects ANAPC1
1 |
ANAPC1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects ALB
1 |
USP37 binds ALB. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP37 affects ADR cells
| 1
USP37 activates ADR cells. 1 / 1
| 1
eidos
"Knockdown of USP37 reduces the chemoresistance of MCF-7 and MCF-7 / ADR cells against adriamycin and activates the mechanism of apoptosis USP37 gene expression in both MCF-7 and MCF-7 / ADR cells was markedly upregulated by the exposure to adriamycin in a dose-dependent manner ( Figure 5A-D ) ."
33390801
USP37 affects ADR cells adriamycin
| 1
USP37 activates ADR cells adriamycin. 1 / 1
| 1
eidos
"In this study , we investigated whether USP37 knockdown could hamper the chemical resistance of MCF-7 and MCF-7 / ADR cells to adriamycin and elucidated the potential mechanism ."
33390801
USP37 affects ADNP
1 |
ADNP binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
USP37 affects 3D
| 1
USP37 inhibits 3D. 1 / 1
| 1
reach
"Depletion of USP37 impairs ccRCC growth in 2D and 3D growth assays and in vivo kidney tumorigenesis and lung metastasis [XREF_BIBR]; therefore, inhibiting USP37 could be a viable therapeutic approach in VHL deficient or HIF-2alpha-dependent tumors."
| PMC
USP37 affects 14-3-3gamma protein
| 1
USP37 increases the amount of 14-3-3gamma protein. 1 / 1
| 1
reach
"USP37 activity is believed to underlie the overexpression of 14-3-3gamma protein and the consequent increase in proliferation of leukemia cells, providing support for an oncogenic role for USP37."
28483947
reach
"Bromodeoxyuridine (BrdU) incorporation into cells released from prometaphase was increased by USP37-FLAG, suggesting accelerated entry into S phase and a role for USP37 in regulating the G1/S transiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
TUBA1A affects USP37
1 |
USP37 binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
26299517
TRIM4 affects USP37
1 |
TRIM4 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
TCF3 affects USP37
1 |
TCF3 decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
TASOR affects USP37
1 |
USP37 binds TASOR. 1 / 1
1 |
biogrid
No evidence text available
26299517
TAF9B affects USP37
1 |
TAF9B binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
TAF6 affects USP37
1 |
TAF6 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
TAF1 affects USP37
1 |
TAF1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
STAG1 affects USP37
1 |
STAG1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
SPEN affects USP37
1 |
SPEN binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
SNU13 affects USP37
1 |
USP37 binds SNU13. 1 / 1
1 |
biogrid
No evidence text available
26299517
SNRNP40 affects USP37
1 |
USP37 binds SNRNP40. 1 / 1
1 |
biogrid
No evidence text available
26299517
SMC3 affects SMC1
| 1
Cohesin binds SMC1, USP37, and SMC3. 1 / 1
| 1
sparser
"Identifying USP37-interacting partners with proximity-dependent biotin identification (BioID) found that USP37 interacts with the cohesin complex proteins SMC3, SMC1, SSCC1, and SA1/2, as well with the regulators of cohesion WAPL and NIPBL [ xref ]."
| PMC
SMC1A affects USP37
1 |
SMC1A binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
SMC1 affects USP37
| 1
Cohesin binds SMC1, USP37, and SMC3. 1 / 1
| 1
sparser
"Identifying USP37-interacting partners with proximity-dependent biotin identification (BioID) found that USP37 interacts with the cohesin complex proteins SMC3, SMC1, SSCC1, and SA1/2, as well with the regulators of cohesion WAPL and NIPBL [ xref ]."
| PMC
SIRT1 affects USP37
1 |
SIRT1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
SF3B5 affects USP37
1 |
USP37 binds SF3B5. 1 / 1
1 |
biogrid
No evidence text available
26299517
SAP18 affects USP37
1 |
SAP18 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
RPA3 affects USP37
1 |
RPA3 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
RPA2 affects USP37
1 |
RPA2 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
RNF168 affects USP37
| 1
RNF168 ubiquitinates USP37. 1 / 1
| 1
sparser
"USP26 and USP37 reverse RNF168-induced ubiquitylation at DSBs."
26101254
eidos
"These results confirmed that USP37 gene expression could be effectively downregulated by siRNA # 2 and siRNA # 3 ."
30482232
REST protein neural cells affects USP37
| 1
REST protein neural cells inhibits USP37. 1 / 1
| 1
eidos
"Blue box indicates the condition during which USP37 expression is elevated due to low level of REST protein in neural cells ."
| PMC
RARA affects USP37
| 1
RARA activates USP37. 1 / 1
| 1
reach
"The retinoic acid receptor alpha (RARA) and the promyelocytic leukemia zinc finger (PLZF) fusion protein is a target of USP37 and the stabilization of PLZF and oncogenic transformation of acute promyelocytic leukemia cells has been attributed to USP37."
28483947
Plant Extracts affects USP37
1 |
Plant Extracts increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
23557933
PRPF19 affects USP37
1 |
PRPF19 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
PRIM2 affects USP37
1 |
USP37 binds PRIM2. 1 / 1
1 |
biogrid
No evidence text available
26299517
PPP1CB affects USP37
1 |
USP37 binds PPP1CB. 1 / 1
1 |
biogrid
No evidence text available
26299517
PPARG affects USP37
1 |
PPARG decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
PPARA affects USP37
1 |
PPARA decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
POLR2H affects USP37
1 |
USP37 binds POLR2H. 1 / 1
1 |
biogrid
No evidence text available
26299517
POGZ affects USP37
1 |
POGZ binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
PNN affects USP37
1 |
USP37 binds PNN. 1 / 1
1 |
biogrid
No evidence text available
26299517
PITX2 affects USP37
1 |
PITX2 decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
PHF2 affects USP37
1 |
USP37 binds PHF2. 1 / 1
1 |
biogrid
No evidence text available
26299517
PAXBP1 affects USP37
1 |
PAXBP1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
Overexpression miR-320b affects USP37
| 1
Overexpression miR-320b inhibits USP37. 1 / 1
| 1
eidos
"Overexpression of miR-320b downregulates USP37 in an in vivo xenograft model , resulting in repression of the CDT1 inhibition of LC progression ."
| PMC
NIPBL affects USP37
1 |
USP37 binds NIPBL. 1 / 1
1 |
biogrid
No evidence text available
26299517
NANOG affects USP10, USP16, USP3, USP37, USP44, and USP7
| 1
USP10 binds USP16, USP3, USP7, USP37, USP44, and NANOG. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
MYC affects Hemagglutinins
| 1
USP37 binds MYC, Hemagglutinins, and 14-3-3γ. 1 / 1
| 1
sparser
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3γ and Myc-USP37."
26427597
MTREX affects USP37
1 |
MTREX binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
MS-275 affects USP37
| 1
MS-275 decreases the amount of USP37. 1 / 1
| 1
reach
"The failure of the HDAC inhibitor, MS-275, to upregulate USP37 expression suggests that either HDAC1/2 activities are not necessary or are alone insufficient to de-repress USP37 expression (XREF_FIG)."
28483947
MIS18A affects USP37
1 |
MIS18A binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
MCM4 affects USP37
1 |
USP37 binds MCM4. 1 / 1
1 |
biogrid
No evidence text available
26299517
MAX affects USP37
1 |
USP37 binds MAX. 1 / 1
1 |
biogrid
No evidence text available
25284584
KRT84 affects USP37
1 |
USP37 binds KRT84. 1 / 1
1 |
biogrid
No evidence text available
19615732
KITLG affects USP37
| 1
FBXW11 binds USP37 and KITLG. 1 / 1
| 1
sparser
"Consistent with this hypothesis, USP37 interacts with components of the SCF in a βTrCP-dependent manner."
23027877
K11 affects USP37
| 1
USP37 binds C-Cdh1 and K11. 1 / 1
| 1
reach
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing - for example, the DUB USP37 interacts with APC and C-Cdh 1 to modulate K11 linkages on at least one substrate."
26835416
Ile-His affects USP37
| 1
Ile-His activates USP37. 1 / 1
| 1
reach
"XREF_BIBR Therefore, it is possible that IH mediated miR-320b reduction in lung cancer cells resulted in the upregulation of USP37, which further promoted cancer cell proliferation, invasion, and survival."
33898105
IRF1 affects USP37
1 |
IRF1 decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
IPO9 affects USP37
1 |
IPO9 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
INTS12 affects USP37
1 |
USP37 binds INTS12. 1 / 1
1 |
biogrid
No evidence text available
26299517
Hemagglutinins affects USP37
| 1
USP37 binds MYC, Hemagglutinins, and 14-3-3γ. 1 / 1
| 1
sparser
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3γ and Myc-USP37."
26427597
HNRNPC affects USP37
1 |
USP37 binds HNRNPC. 1 / 1
1 |
biogrid
No evidence text available
26299517
HNRNPA3 affects USP37
1 |
USP37 binds HNRNPA3. 1 / 1
1 |
biogrid
No evidence text available
26299517
HIF1A affects USP37
1 |
HIF1A decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
HDAC2 affects USP37
1 |
USP37 binds HDAC2. 1 / 1
1 |
biogrid
No evidence text available
26299517
HDAC1 affects USP37
1 |
USP37 binds HDAC1. 1 / 1
1 |
biogrid
No evidence text available
26299517
HA-14-3-3gamma affects USP37
| 1
USP37 binds HA-14-3-3gamma. 1 / 1
| 1
reach
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3gamma and Myc-USP37."
26427597
H2AZ1 affects USP37
1 |
USP37 binds H2AZ1. 1 / 1
1 |
biogrid
No evidence text available
26299517
GTF3C3 affects USP37
1 |
USP37 binds GTF3C3. 1 / 1
1 |
biogrid
No evidence text available
26299517
GSK3B affects USP37
| 1
GSK3B activates USP37. 1 / 1
| 1
reach
"Besides, silencing of endogenous GSK-3beta impeded USP37 mediated stabilization of Snail1 in AGS cells."
33391500
G9a pharmacological affects USP37
| 1
G9a pharmacological inhibits USP37. 1 / 1
| 1
eidos
"Furthermore , inhibiting G9a activity with pharmacological inhibitors reactivate USP37 expression , stabilizing p27 and its target genes ( Fig. 4 ) ."
| PMC
G1 affects USP37
| 1
USP37 binds APC/C Cdh1 and G1. 1 / 1
| 1
reach
"Usp37 binds APC/C Cdh1 in G1 and deubiquitinates the APC/C substrate cyclin A [XREF_BIBR]."
21978762
FBXW11 affects KITLG, and USP37
| 1
FBXW11 binds USP37 and KITLG. 1 / 1
| 1
sparser
"Consistent with this hypothesis, USP37 interacts with components of the SCF in a βTrCP-dependent manner."
23027877
EXOSC9 affects USP37
1 |
USP37 binds EXOSC9. 1 / 1
1 |
biogrid
No evidence text available
26299517
ESRRA affects USP37
1 |
ESRRA decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
ESR1 affects USP37
| 1
USP37 binds ESR1. 1 / 1
| 1
sparser
"Further mechanistic study revealed the interaction between USP37 and ERα: USP37 regulated ERα signaling through modulating protein stability instead of gene expression, in which it stabilized ERα protein via inhibiting the K48-specific poly-ubiquitination process."
36221793
EHMT2 affects USP37
| 1
EHMT2 inhibits USP37. 1 / 1
| 1
eidos
"G9a reduces USP37 expression by promoting H3K9 mono - , di - , and trimethylation at its promoter ."
| PMC
EGR2 affects USP37
1 |
EGR2 decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
EGFR affects USP37
| 1
EGFR inhibits USP37. 1 / 1
| 1
reach
"Taken together, our results show that the prolonged treatment of NSCLC cells with gefitinib mediates strong degradation of EGFR, elevating intracellular ubiquitination and autophagy and resulting in apoptotic cell death.In summary, the present study demonstrates that gefitinib-mediated EGFR degradation is dependent on the mutation variations in the EGFR kinase domain, and miR-4487 contributes to the subsequent elevation of gefitinib-mediated ubiquitination, autophagy, and apoptotic cell death by directly targeting USP37."
34352998
ECH1 affects USP37
1 |
USP37 binds ECH1. 1 / 1
1 |
biogrid
No evidence text available
26299517
EC 3.5.1.98 (histone deacetylase) inhibitor decreases the amount of USP37. 1 / 1
| 1
reach
"The failure of the HDAC inhibitor, MS-275, to upregulate USP37 expression suggests that either HDAC1/2 activities are not necessary or are alone insufficient to de-repress USP37 expression (XREF_FIG)."
28483947
DPY30 affects USP37
1 |
USP37 binds DPY30. 1 / 1
1 |
biogrid
No evidence text available
26299517
DHX15 affects USP37
1 |
USP37 binds DHX15. 1 / 1
1 |
biogrid
No evidence text available
26299517
D-aspartic acid affects USP37
| 1
D-aspartic acid increases the amount of USP37. 1 / 1
| 1
reach
"Notably, Das et al. reported that REST induces medulloblastoma oncogenesis by repressing USP37 transcription, thereby leading to low levels of the p27 tumor suppressor, which controls proliferation and cell cycle exit by inhibiting CDK1 in cerebellar progenitor cells."
| PMC
Cohesin affects WAPL
| 1
Cohesin binds USP37 and WAPL. 1 / 1
| 1
sparser
"The authors further demonstrated that USP37 interacts with both cohesin and a negative regulator WAPL, which is required for releasing cohesin from chromatid arms in prophase."
32201366
Cohesin affects SMC3
| 1
Cohesin binds SMC1, USP37, and SMC3. 1 / 1
| 1
sparser
"Identifying USP37-interacting partners with proximity-dependent biotin identification (BioID) found that USP37 interacts with the cohesin complex proteins SMC3, SMC1, SSCC1, and SA1/2, as well with the regulators of cohesion WAPL and NIPBL [ xref ]."
| PMC
Carcinogenesis affects USP37
| 1
Carcinogenesis activates USP37. 1 / 1
| 1
reach
"Therefore, USP37 drives oncogenesis by altering the stability of various oncoproteins and activating downstream signaling pathways."
| PMC
CUL1 affects USP37
1 |
USP37 binds CUL1. 1 / 1
1 |
biogrid
No evidence text available
23027877
CHERP affects USP37
1 |
CHERP binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
CHD8 affects USP37
1 |
USP37 binds CHD8. 1 / 1
1 |
biogrid
No evidence text available
26299517
CDK2 inhibitor affects USP37
| 1
CDK2 inhibitor increases the amount of USP37. 1 / 1
| 1
reach
"In addition, CDK2 inhibitor II (Nakamura et al., 2007) treatment of HeLa cells arrested in G1/S decreased the amount of active USP37, but not total DUB activity."
21596315
CDH1 affects vIRF-2
| 1
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
CDH1 affects CDC20
| 1
CDC20 binds CDH1 and USP37. 1 / 1
| 1
sparser
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
CDC23 affects USP37
1 |
CDC23 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
CDC20 affects CDH1, and USP37
| 1
CDC20 binds CDH1 and USP37. 1 / 1
| 1
sparser
"Huang et al. characterized the USP37 interaction with CDH1 and CDC20 by tandem mass spectrometry and found that USP37 interacts with CDH1 but not CDC20."
| PMC
CDC16 affects USP37
1 |
CDC16 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
CD59 affects USP37
| 1
CD59 activates USP37. 1 / 1
| 1
reach
"Immunopurified USP37 protein treated with CIP also had a lower DUB activity compared to untreated USP37."
21596315
CBX3 affects USP37
1 |
CBX3 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
C-Cdh1 affects USP37
| 1
USP37 binds C-Cdh1 and K11. 1 / 1
| 1
reach
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing - for example, the DUB USP37 interacts with APC and C-Cdh 1 to modulate K11 linkages on at least one substrate."
26835416
BRIP1 affects USP37
1 |
USP37 binds BRIP1. 1 / 1
1 |
biogrid
No evidence text available
26299517
BRCA1 affects USP37
1 |
BRCA1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
Antigen-Presenting Cells ubiquitinates USP37. 1 / 1
| 1
reach
"Inactive USP37 is ubiquitinated by E3 ubiquitin ligase APC and degraded in the proteasome (Huang et al., 2011)."
33169399
AZM551248 affects USP37
1 |
AZM551248 decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
22323515
APC_C affects vIRF-2
| 1
APC_C binds CDH1, USP37, and vIRF-2. 1 / 1
| 1
sparser
"Finally, specificity for Cdh1 may introduce possibilities for modulating the degradation of substrates via chain editing – for example, the DUB USP37 interacts with APC/C–Cdh1 to modulate K11 linkages on at least one substrate ( xref )."
26835416
APC_C affects CDH1, and USP37
| 1
APC_C binds CDH1 and USP37. 1 / 1
| 1
sparser
"The core components of APC bind with USP37 through CDH1."
| PMC
APC/C Cdh1 affects USP37
| 1
USP37 binds APC/C Cdh1 and G1. 1 / 1
| 1
reach
"Usp37 binds APC/C Cdh1 in G1 and deubiquitinates the APC/C substrate cyclin A [XREF_BIBR]."
21978762
APC-CDH1 complex affects USP37
| 1
APC-CDH1 complex inhibits USP37. 1 / 1
| 1
eidos
"B In the late G2 / M phase , USP37 acts as a substrate of the APC / C complex via phosphorylation by PLK1 and is further ubiquitinated by betaTrCP for the biphasic degradation , resulting in the downregulation of USP37 , necessary for the G2 / M phase transition Interestingly , the APC-CDH1 complex degrades USP37 in late mitosis by targeting its KEN box degron ."
| PMC
APC affects USP37
| 1
APC inhibits USP37. 1 / 1
| 1
reach
"Other APC CDH1 substrates, including CDC20, CDC6, PLK1, Aurora kinase A, and SKP2, were not decreased by USP37 knockdown, indicating a specific effect of USP37 on cyclin A abundance.Coimmunoprecipitat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
ANAPC16 affects USP37
1 |
USP37 binds ANAPC16. 1 / 1
1 |
biogrid
No evidence text available
26299517
ANAPC15 affects USP37
1 |
USP37 binds ANAPC15. 1 / 1
1 |
biogrid
No evidence text available
26299517
ANAPC13 affects USP37
1 |
USP37 binds ANAPC13. 1 / 1
1 |
biogrid
No evidence text available
26299517
ANAPC1 affects USP37
1 |
ANAPC1 binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
ALPI affects USP37
| 1
ALPI inhibits USP37. 1 / 1
| 1
reach
"These slow migrating species were phosphorylated USP37 because the bands disappeared from lysates treated with calf intestinal alkaline phosphatase."
21596315
ALB affects USP37
1 |
USP37 binds ALB. 1 / 1
1 |
biogrid
No evidence text available
19615732
AHR affects USP37
1 |
AHR decreases the amount of USP37. 1 / 1
1 |
biopax:msigdb
No evidence text available
ADNP affects USP37
1 |
ADNP binds USP37. 1 / 1
1 |
biogrid
No evidence text available
26299517
4-hydroxynon-2-enal decreases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
19191707
17alpha-ethynylestradiol increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
23129252
14-3-3γ affects MYC
| 1
USP37 binds MYC, Hemagglutinins, and 14-3-3γ. 1 / 1
| 1
sparser
"We used a cell counting kit-8 (CCK-8) to measure the cell viability and proliferation mediated by the interaction between HA-14-3-3γ and Myc-USP37."
26427597
2,3',4,4',5-pentachlorobiphenyl increases the amount of USP37. 1 / 1
1 |
ctd
No evidence text available
31388691