IndraLab
Statements
USP3 affects Delta-actitoxin-Avd1a
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45
Delta-actitoxin-Avd1a binds USP3. 10 / 43
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43
OXT binds MUC20, Delta-actitoxin-Avd1a, and USP3. 2 / 2
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2
sparser
"Our data showed strong positive correlations between MALAT1 expression and the expression of AC005154.1, NEAT1, AL139022.1, AC007622.2, USP3-AS1, MUC20-OT1, LINC-PINT, and AC103810.5 (Fig. xref ), highlighting a plausible reciprocal relationship between MALAT1 and the identified lncRNAs in TNBC."
USP3 affects cell population proliferation
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42
USP3 activates cell population proliferation.
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34
USP3 activates cell population proliferation. 10 / 34
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34
reach
"Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells by mediating deubiquitination of Aurora A. Analysis of human clinical samples indicated that USP3 and Aurora A are highly expressed in ESCC."
USP3 inhibits cell population proliferation.
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8
sparser
"To determine the physiological relevance of these findings, we stimulated the THP‐1 cells or peripheral blood mononuclear cells (PBMCs) with LPS and found that the interaction between MyD88 and USP3 was induced by LPS treatment and peaked at 60 min after LPS treatment, which correlated with p‐IKK activation (Fig xref )."
reach
"We intend to perform long‐term experiments to investigate the duration of innate immune tolerance involving USP3 in the future.Although we found that USP3 inhibits MyD88‐dependent NF‐κB signaling activation by removing the K63‐linked polyubiquitin chains on MyD88, it remains unclear why K63‐linked polyubiquitin chains are so crucial for MyD88‐dependent NF‐κB signaling activation."
reach
"To identify the molecular target of USP3, we co‐transfected USP3 with different signaling proteins in the NF‐κB pathway and found that USP3 mainly inhibited MyD88‐induced NF‐κB activation and slightly but significantly inhibited TRAF6‐induced NF‐κB activity only at a high USP3 concentration (Fig 3A)."
reach
"Ubiquitylation events are reversible processes, and, accordingly, several deubiquitylating enzymes, in particular ubiquitin specific peptidase 3 (USP3), USP21 and CYLD lysine 63 deubiquitinase (CYLD), modulate RIG-I signalling by removing K63-polyubiquitin chains, although with unique kinetics."
sparser
"To determine the physiological relevance of these findings, we stimulated the THP‐1 cells or peripheral blood mononuclear cells (PBMCs) with LPS and found that the interaction between MyD88 and USP3 was induced by LPS treatment and peaked at 60 min after LPS treatment, which correlated with p‐IKK activation (Fig xref )."
USP3 affects Neoplasm Metastasis
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3
19
USP3 activates Neoplasm Metastasis.
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3
15
USP3 activates Neoplasm Metastasis. 10 / 18
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3
15
reach
"Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells by mediating deubiquitination of Aurora A. Analysis of human clinical samples indicated that USP3 and Aurora A are highly expressed in ESCC."
USP3 inhibits Neoplasm Metastasis.
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4
"<span class="match term0">USP3</span> interacts directly with <span class="match term1">Snail</span> and stabilizes <span class="match term1">Snail</span> via deubiquitination"
reach
"Deubiquitinases (DUBs) also play an important role in the regulation of Snail1 protein stability, including USP3, USP11, USP13, DUB3, USP18, USP26, USP27X, USP37, USP47, OTUB1, and PSMD14, that have been shown to facilitate deubiquitination and stabilization of nuclear Snail1 in promoting cell proliferation, migration, and invasion ."
USP3 affects Neoplasm Invasiveness
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19
USP3 activates Neoplasm Invasiveness.
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15
USP3 inhibits Neoplasm Invasiveness.
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4
sparser
"Notably, unlike USP3, the active region of USP38 is located at the amino terminus (1-400aa), indicating that although both USP38 and USP3 bind to the same active region of KLF5, the differences in their respective active regions may lead to differential sensitivity in regulating KLF5 expression."
reach
"By virtue of its ability to oppose histone H2A ubiquitylation and the fact that USP3 over-expression can block accumulation of the ubiquitin E3 ligase RNF168 at DSB sites, USP3 has been linked to the key RNF8-RNF168 pathway of assembling repair and signalling components at DSB sites [XREF_BIBR]."
reach
"Collectively, our results suggest that although USP3 could moderately reduce TRAF6‐induced NF‐κB activation (Zhou et al, 2019), it specifically inhibits TLR‐ and IL‐1β‐induced NF‐κB activation, mainly through the adaptor molecule MyD88.We next sought to determine whether USP3 could interact with MyD88."
reach
"To identify the molecular target of USP3, we co‐transfected USP3 with different signaling proteins in the NF‐κB pathway and found that USP3 mainly inhibited MyD88‐induced NF‐κB activation and slightly but significantly inhibited TRAF6‐induced NF‐κB activity only at a high USP3 concentration (Fig 3A)."
reach
"USP3, one of the DUBs with the highest expression of USP family genes in neuroblastoma, is positively correlated with REST, a transcriptional repressor in non-neuronal cells and neural stem cells [51], and USP3 promotes tumor formation and growth by stabilizing the level of REST proteins through deubiquitination [52]."
reach
"These data demonstrate that USP3 regulates cellular response to docetaxel in prostate cancer cells in a SMARCA5 dependent manner.Collectively, we reveal that USP3 binds SMARCA5 and removed K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance (Fig. 6K)."
sparser
"Collectively, our findings uncover a novel molecular mechanism for the USP3-SMARCA5 axis in regulating DSB repair with an important role in chemotherapy response in human prostate cancers, highlighting that targeting USP3-SMARCA5 axis could be a valuable strategy to treat USP3/SMARCA5-overexpressing chemotherapy-resistant patients and improve drug treatment."
reach
"Herein, we report one critical target of USP3, SMARCA5 and the specific mechanism of USP3-mediated deubiquitination of SMARCA5 in Docetaxel-inducing DNA damage, suggesting that USP3 may be a promising target for anticancer therapy in prostate cancer.SMARCA5, the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, was required for DNA-templated events including transcription, DNA replication, and DNA repair [17, 18]."
reach
"The immunoprecipitated samples was eluted using an elution buffer and subsequently analyzed via western blot assay.To verify the domains of DNM1L binds to USP3, various HA-tagged DNM1L deletion mutants (including HA-1–302 aa, HA-303–643 aa, and HA-644–736 aa) or HA-full constructs (HA-1–736 aa) and Flag-USP3 constructs were generated in the pcDNA3.1 vector."
sparser
"USP3 binds the GTPase domain (1–302 aa) of DNM1L and selectively cleaves K48-linked ubiquitin chains, prolonging DNM1L half-life and promoting its induction of excessive mitochondrial fission, ATP depletion, reactive oxygen species (ROS) accumulation, and mitochondrial DNA (mtDNA) loss."
sparser
"Additionally, a study has revealed that USP3 interacts with checkpoint kinase 1 (CHK1), counteracting the effects of BTG3‐mediated K63‐linked polyubiquitination of CHK1. xref This interaction turns off CHK1 phosphorylation and activation by upstream kinases, facilitating CHK1 release from chromatin to exert its kinase activity on other substrates."
"Herein, we show that the K63-linked ubiquitin chain at <span class="match term1">CHK1</span>'s K132 residue has an inhibitory effect on the kinase activity. Furthermore, we demonstrate that this modification can be removed by ubiquitin-specific protease 3 (<span class="match term0">USP3</span>), a deubiquitinating enzyme that targets K63-linked ubiquitin chains."
USP3 affects Stomach Neoplasms
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3
7
USP3 activates Stomach Neoplasms.
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3
6
USP3 inhibits Stomach Neoplasms.
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1
USP3 inhibits Stomach Neoplasms. 1 / 1
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1
USP3 affects Interferon
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10
USP3 inhibits Interferon.
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7
USP3 increases the amount of Interferon.
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1
USP3 increases the amount of Interferon. 1 / 1
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1
USP3 deubiquitinates Interferon.
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1
USP3 deubiquitinates Interferon. 1 / 1
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1
USP3 activates Interferon.
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1
USP3 activates Interferon. 1 / 1
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1
USP3 affects Histone_H2B
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10
USP3 deubiquitinates Histone_H2B.
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9
USP3 deubiquitinates Histone_H2B. 7 / 7
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7
USP3 leads to the deubiquitination of Histone_H2B on K119. 1 / 1
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1
USP3 leads to the deubiquitination of Histone_H2B on K120. 1 / 1
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1
USP3 binds Histone_H2B.
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1
USP3 binds Histone_H2B. 1 / 1
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1
sparser
"To determine differentially expressed proteins that may serve as potential interaction targets of USP3, total protein extracted from the treated BGC-823 cells stably expressing the Flag-USP3 fusion protein and the BGC-823 cells carrying an empty vector was analyzed using iTRAQ experiments."
sparser
"Notably, unlike USP3, the active region of USP38 is located at the amino terminus (1-400aa), indicating that although both USP38 and USP3 bind to the same active region of KLF5, the differences in their respective active regions may lead to differential sensitivity in regulating KLF5 expression."
sparser
"To determine differentially expressed proteins that may serve as potential interaction targets of USP3, total protein extracted from the treated BGC-823 cells stably expressing the Flag-USP3 fusion protein and the BGC-823 cells carrying an empty vector was analyzed using iTRAQ experiments."
reach
"By virtue of its ability to oppose histone H2A ubiquitylation and the fact that USP3 over-expression can block accumulation of the ubiquitin E3 ligase RNF168 at DSB sites, USP3 has been linked to the key RNF8-RNF168 pathway of assembling repair and signalling components at DSB sites [XREF_BIBR]."
reach
"The downregulation of USP3 significantly elevates uH2A and uH2B protein levels, leading to functional consequences such as replication stress, abnormal DNA replication and/or recombination, delayed S‐phase progression, accumulation of DNA breaks, and hyperactivation of ATR/ATM‐regulated checkpoint responses."
sparser
"Additionally, a study has revealed that USP3 interacts with checkpoint kinase 1 (CHK1), counteracting the effects of BTG3‐mediated K63‐linked polyubiquitination of CHK1. xref This interaction turns off CHK1 phosphorylation and activation by upstream kinases, facilitating CHK1 release from chromatin to exert its kinase activity on other substrates."
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8
reach
"The known role of ALYREF as a regulator of DNA binding guided further analyses that uncovered ALYREF-MYCN interaction in a nuclear coactivator complex which stimulates transcription of the ‘ubiquitin specific peptidase 3′ (USP3), consequently reducing MYCN ubiquitination and degradation."
| PMC
"We show that increased <span class="match term0">USP3</span> levels reduce K-48- and K-63-linked ubiquitination of <span class="match term1">MYCN</span>, thus driving up <span class="match term1">MYCN</span> protein stability"
USP3 affects cell migration
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7
USP3 activates cell migration.
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4
USP3 inhibits cell migration.
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3
USP3 increases the amount of USP3.
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3
USP3 activates USP3.
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2
reach
"Although we observed the existence of cytoplasmic USP3 even without LPS stimulation in USP3‐expressing THP‐1 cells, possibly due to the overexpression of USP3, LPS pretreatment still increased the amount of cytoplasmic USP3 in these cells (Fig EV5C), indicating that LPS‐pretreatment induces the cytoplasmic retention of both endogenous and exogenous USP3 in THP‐1 cells."
USP3 inhibits USP3.
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1
USP3 decreases the amount of USP3.
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1
reach
"These data demonstrate that USP3 regulates cellular response to docetaxel in prostate cancer cells in a SMARCA5 dependent manner.Collectively, we reveal that USP3 binds SMARCA5 and removed K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance (Fig. 6K)."
sparser
"Collectively, our findings uncover a novel molecular mechanism for the USP3-SMARCA5 axis in regulating DSB repair with an important role in chemotherapy response in human prostate cancers, highlighting that targeting USP3-SMARCA5 axis could be a valuable strategy to treat USP3/SMARCA5-overexpressing chemotherapy-resistant patients and improve drug treatment."
reach
"The immunoprecipitated samples was eluted using an elution buffer and subsequently analyzed via western blot assay.To verify the domains of DNM1L binds to USP3, various HA-tagged DNM1L deletion mutants (including HA-1–302 aa, HA-303–643 aa, and HA-644–736 aa) or HA-full constructs (HA-1–736 aa) and Flag-USP3 constructs were generated in the pcDNA3.1 vector."
sparser
"USP3 binds the GTPase domain (1–302 aa) of DNM1L and selectively cleaves K48-linked ubiquitin chains, prolonging DNM1L half-life and promoting its induction of excessive mitochondrial fission, ATP depletion, reactive oxygen species (ROS) accumulation, and mitochondrial DNA (mtDNA) loss."
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3
3
USP3 affects proteolysis
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6
USP3 activates proteolysis.
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4
USP3 inhibits proteolysis.
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2
reach
"To identify the molecular target of USP3, we co‐transfected USP3 with different signaling proteins in the NF‐κB pathway and found that USP3 mainly inhibited MyD88‐induced NF‐κB activation and slightly but significantly inhibited TRAF6‐induced NF‐κB activity only at a high USP3 concentration (Fig 3A)."
Lipopolysaccharide affects USP3
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5
Lipopolysaccharide activates USP3. 5 / 5
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5
reach
"Although we observed the existence of cytoplasmic USP3 even without LPS stimulation in USP3‐expressing THP‐1 cells, possibly due to the overexpression of USP3, LPS pretreatment still increased the amount of cytoplasmic USP3 in these cells (Fig EV5C), indicating that LPS‐pretreatment induces the cytoplasmic retention of both endogenous and exogenous USP3 in THP‐1 cells."
reach
"These data demonstrate that USP3 regulates cellular response to docetaxel in prostate cancer cells in a SMARCA5 dependent manner.Collectively, we reveal that USP3 binds SMARCA5 and removed K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance (Fig. 6K)."
USP3 affects Circulin-C
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5
USP3 affects Carcinogenesis
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5
reach
"These data demonstrate that USP3 regulates cellular response to docetaxel in prostate cancer cells in a SMARCA5 dependent manner.Collectively, we reveal that USP3 binds SMARCA5 and removed K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance (Fig. 6K)."
Circulin-C affects USP3
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5
Pirinixic acid affects USP3
4
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Pirinixic acid increases the amount of USP3.
2
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Pirinixic acid decreases the amount of USP3.
1
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Pirinixic acid activates USP3.
1
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USP3 affects glycolytic process
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4
USP3 activates glycolytic process. 4 / 4
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4
reach
"It promotes cell proliferation, invasion, migration, DNA damage repair, and glycolysis, potentially via the Wnt/β-catenin signaling pathway.14 Similarly, USP3 promotes cholangiocarcinoma proliferation and invasion through the Wnt/MYC pathway, enhancing tumor cell glycolysis, energy production, and upregulating metabolic target genes such as GLUT1, HK2, PDM2, and LDHA.87
Egfr/Stat3."
USP3 affects Neuroblastoma
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4
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4
USP3 activates Esophageal Squamous Cell Carcinoma. 4 / 4
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4
reach
"Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells by mediating deubiquitination of Aurora A. Analysis of human clinical samples indicated that USP3 and Aurora A are highly expressed in ESCC."
SMARCA5 affects K63
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4
reach
"These data demonstrate that USP3 regulates cellular response to docetaxel in prostate cancer cells in a SMARCA5 dependent manner.Collectively, we reveal that USP3 binds SMARCA5 and removed K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance (Fig. 6K)."
reach
"These data demonstrate that USP3 regulates cellular response to docetaxel in prostate cancer cells in a SMARCA5 dependent manner.Collectively, we reveal that USP3 binds SMARCA5 and removed K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance (Fig. 6K)."
Air Pollutants affects USP3
4
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Air Pollutants increases the amount of USP3.
2
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Air Pollutants decreases the amount of USP3.
2
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Polyubiquitin affects USP3
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3
Polyubiquitin chains affects USP3
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3
reach
"We further show that there is no interaction between USP3 and RIG-I-like receptors (RLRs) in unstimulated or uninfected cells, but upon viral infection or ligand stimulation, USP3 binds to the caspase activation recruitment domain of RLRs and then cleaves polyubiquitin chains through cooperation of its zinc-finger Ub binding domain and USP catalytic domains."
Cyclosporin A affects USP3
3
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Bisphenol A affects USP3
3
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USP3 affects polyubiquitin
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3
USP3 affects polyubiquitin chains
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3
reach
"We further show that there is no interaction between USP3 and RIG-I-like receptors (RLRs) in unstimulated or uninfected cells, but upon viral infection or ligand stimulation, USP3 binds to the caspase activation recruitment domain of RLRs and then cleaves polyubiquitin chains through cooperation of its zinc-finger Ub binding domain and USP catalytic domains."
USP3 affects gammaH2AX
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3
USP3 affects apoptotic process
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3
USP3 affects Osteosarcoma
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3
USP3 activates Osteosarcoma.
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2
USP3 activates Osteosarcoma. 2 / 2
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2
USP3 inhibits Osteosarcoma.
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1
USP3 inhibits Osteosarcoma. 1 / 1
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1
USP3 affects Infections
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3
USP3 affects Glioblastoma
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2
1
USP3 affects DNA Damage
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3
USP3 inhibits DNA Damage.
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2
USP3 activates DNA Damage.
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1
USP3 activates DNA Damage. 1 / 1
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1
reach
"It promotes cell proliferation, invasion, migration, DNA damage repair, and glycolysis, potentially via the Wnt/β-catenin signaling pathway.14 Similarly, USP3 promotes cholangiocarcinoma proliferation and invasion through the Wnt/MYC pathway, enhancing tumor cell glycolysis, energy production, and upregulating metabolic target genes such as GLUT1, HK2, PDM2, and LDHA.87
Egfr/Stat3."
3
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2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP3.
2
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2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP3.
1
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Valproic acid affects USP3
2
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Valproic acid increases the amount of USP3.
1
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Valproic acid decreases the amount of USP3.
1
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Titanium dioxide affects USP3
2
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Titanium dioxide increases the amount of USP3.
1
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Titanium dioxide demethylates USP3.
1
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Polyubiquitin affects IFIH1
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2
Phenethyl isothiocyanate affects USP3
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1
1
Mono(2-ethylhexyl) phthalate affects USP3
2
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Mono(2-ethylhexyl) phthalate methylates USP3.
1
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Mono(2-ethylhexyl) phthalate increases the amount of USP3.
1
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MiR-224-5p affects USP3
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2
LncRNA HOXA-AS3 affects USP3
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2
Hsa-miR-26b-5p affects USP3
2
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Bis(2-ethylhexyl) phthalate affects USP3
2
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Bis(2-ethylhexyl) phthalate methylates USP3.
1
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Bis(2-ethylhexyl) phthalate increases the amount of USP3.
1
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Aflatoxin B1 affects USP3
2
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Aflatoxin B1 increases the amount of USP3.
1
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Aflatoxin B1 demethylates USP3.
1
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USP3 affects protein deubiquitination
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2
USP3 affects immune response
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2
USP3 affects cell differentiation
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2
USP3 inhibits cell differentiation.
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1
USP3 inhibits cell differentiation. 1 / 1
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1
USP3 activates cell differentiation.
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1
USP3 activates cell differentiation. 1 / 1
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1
USP3 affects angiogenesis
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2
USP3 affects activity
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2
USP3 affects Virus Diseases
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2
USP3 inhibits Virus Diseases. 2 / 2
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2
reach
"Overall, our data suggest that USP3 protein expression levels in HIV-1-infected individuals can be used to indicate HIV viral load and may serve as a new biomarker for evaluating the prognosis of HIV-1-infected patients.In summary, we found that USP3 restricts HIV-1 viral infections by increasing the expression of antiviral factor A3G."
USP3 affects RIG-I-like receptors
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2
USP3 affects Phosphatase
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2
USP3 increases the amount of Phosphatase.
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1
USP3 increases the amount of Phosphatase. 1 / 1
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1
USP3 deubiquitinates Phosphatase.
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1
USP3 deubiquitinates Phosphatase on A25. 1 / 1
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1
OXT binds MUC20, Delta-actitoxin-Avd1a, and USP3. 2 / 2
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2
sparser
"Our data showed strong positive correlations between MALAT1 expression and the expression of AC005154.1, NEAT1, AL139022.1, AC007622.2, USP3-AS1, MUC20-OT1, LINC-PINT, and AC103810.5 (Fig. xref ), highlighting a plausible reciprocal relationship between MALAT1 and the identified lncRNAs in TNBC."
OXT binds MUC20, Delta-actitoxin-Avd1a, and USP3. 2 / 2
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2
sparser
"Our data showed strong positive correlations between MALAT1 expression and the expression of AC005154.1, NEAT1, AL139022.1, AC007622.2, USP3-AS1, MUC20-OT1, LINC-PINT, and AC103810.5 (Fig. xref ), highlighting a plausible reciprocal relationship between MALAT1 and the identified lncRNAs in TNBC."
USP3 affects K63-polyubiquitin chains
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2
reach
"Ubiquitylation events are reversible processes, and, accordingly, several deubiquitylating enzymes, in particular ubiquitin specific peptidase 3 (USP3), USP21 and CYLD lysine 63 deubiquitinase (CYLD), modulate RIG-I signalling by removing K63-polyubiquitin chains, although with unique kinetics."
USP3 affects IKKβ protein
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2
USP3 affects IFN-I
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2
USP3 affects Fan
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2
reach
"Nevertheless, our results reveal that USP3 regulates the stability, ubiquitination and thus the function of SMARCA5, providing a mechanistic link between the deubiquitinase USP3 and the SMARCA5-mediated DDR.In summary, we demonstrate that deletion of USP3 inhibits PCa cell growth in vitro and in vivo."
USP3 affects DNA Breaks, Double-Stranded
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2
RT-qPCR affects USP3
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2
OXT binds MUC20, Delta-actitoxin-Avd1a, and USP3. 2 / 2
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2
sparser
"Our data showed strong positive correlations between MALAT1 expression and the expression of AC005154.1, NEAT1, AL139022.1, AC007622.2, USP3-AS1, MUC20-OT1, LINC-PINT, and AC103810.5 (Fig. xref ), highlighting a plausible reciprocal relationship between MALAT1 and the identified lncRNAs in TNBC."
USP3 is modified
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1
1
USP3 is phosphorylated.
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1
USP3 is produced.
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1
MicroRNA-146-5p affects USP3
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2
OXT binds MUC20, Delta-actitoxin-Avd1a, and USP3. 2 / 2
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2
sparser
"Our data showed strong positive correlations between MALAT1 expression and the expression of AC005154.1, NEAT1, AL139022.1, AC007622.2, USP3-AS1, MUC20-OT1, LINC-PINT, and AC103810.5 (Fig. xref ), highlighting a plausible reciprocal relationship between MALAT1 and the identified lncRNAs in TNBC."
IFIH1 affects polyubiquitin
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2
reach
"Among SNPs at the locus with
P < 1 × 10 , many have
been reported as cis-eQTLs in whole blood and other tissues
with febrile seizures risk alleles corresponding to decreased expression of
HERC1, USP3, DAPK2 and
PLEKHO2, and increased expression of
FBXL22, APH1B and RBPMS2
(Supplementary Table
5)."
Dronabinol affects USP3
2
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Delta-actitoxin-Avd1a affects OXT
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2
OXT binds MUC20, Delta-actitoxin-Avd1a, and USP3. 2 / 2
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2
sparser
"Our data showed strong positive correlations between MALAT1 expression and the expression of AC005154.1, NEAT1, AL139022.1, AC007622.2, USP3-AS1, MUC20-OT1, LINC-PINT, and AC103810.5 (Fig. xref ), highlighting a plausible reciprocal relationship between MALAT1 and the identified lncRNAs in TNBC."
reach
"MYCN, a stable oncogenic transcription factor, is tightly regulated by the ubiquitin-proteasome system and partially relies on ALYREF for promoting enhanced cancer cell viability and proliferation [49], while ALYREF inhibits MYCN degradation by directly transcribing USP3 at levels necessary to facilitate tumor growth."
1
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Trichostatin A affects USP3
1
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Transcriptional activator affects USP3
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1
Transcriptional activator increases the amount of USP3. 1 / 1
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1
Polyubiquitin affects K63
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1
Polyubiquitin chains affects CARD domain
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1
Phorbol 13-acetate 12-myristate affects USP3
1
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Peptidase activity affects USP3
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1
USP3 binds peptidase activity. 1 / 1
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1
Pentachlorophenol affects USP3
1
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Nuclear coactivator affects USP3
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1
Nuclear coactivator increases the amount of USP3. 1 / 1
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1
Nefazodone affects USP3
1
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MicroRNA-146-5p affects USP3
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1
MiR-33a affects USP3
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1
reach
"For supportive host factors, miR-1-3p, miR-17-3p, miR-193b, miR-203, miR-221, miR-26a, miR-30, miR-324-5p, miR-33a, and miR-548an respectively inhibit the expression of ATP6V1A, GALNT3, β-catenin, DR1, GALNT3, USP3, NEDD4, CUEDC2, ARCN1, and NS1ABP to inhibit IAV replication ultimately, but miR-34c promotes PLK4 expression to promote IAV replication."
MiR-30 affects USP3
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1
reach
"For supportive host factors, miR-1-3p, miR-17-3p, miR-193b, miR-203, miR-221, miR-26a, miR-30, miR-324-5p, miR-33a, and miR-548an respectively inhibit the expression of ATP6V1A, GALNT3, β-catenin, DR1, GALNT3, USP3, NEDD4, CUEDC2, ARCN1, and NS1ABP to inhibit IAV replication ultimately, but miR-34c promotes PLK4 expression to promote IAV replication."
MiR-203 affects USP3
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1
reach
"For supportive host factors, miR-1-3p, miR-17-3p, miR-193b, miR-203, miR-221, miR-26a, miR-30, miR-324-5p, miR-33a, and miR-548an respectively inhibit the expression of ATP6V1A, GALNT3, β-catenin, DR1, GALNT3, USP3, NEDD4, CUEDC2, ARCN1, and NS1ABP to inhibit IAV replication ultimately, but miR-34c promotes PLK4 expression to promote IAV replication."
MiR-193b affects USP3
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1
reach
"For supportive host factors, miR-1-3p, miR-17-3p, miR-193b, miR-203, miR-221, miR-26a, miR-30, miR-324-5p, miR-33a, and miR-548an respectively inhibit the expression of ATP6V1A, GALNT3, β-catenin, DR1, GALNT3, USP3, NEDD4, CUEDC2, ARCN1, and NS1ABP to inhibit IAV replication ultimately, but miR-34c promotes PLK4 expression to promote IAV replication."
MiR-17-3p affects USP3
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1
reach
"For supportive host factors, miR-1-3p, miR-17-3p, miR-193b, miR-203, miR-221, miR-26a, miR-30, miR-324-5p, miR-33a, and miR-548an respectively inhibit the expression of ATP6V1A, GALNT3, β-catenin, DR1, GALNT3, USP3, NEDD4, CUEDC2, ARCN1, and NS1ABP to inhibit IAV replication ultimately, but miR-34c promotes PLK4 expression to promote IAV replication."
MiR-146b-5p.To affects USP3
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1
MiR-146b-5p affects USP3
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1
MiR-146b-5p inhibitor affects USP3
|
1
MiR-146-5p affects USP3
|
1
MiR-1245b-5p affects USP3
|
1
Methyl methanesulfonate affects USP3
1
|
Methotrexate affects USP3
1
|
Methimazole affects USP3
1
|
Leptomycin B affects USP3
|
1
Leptomycin B inhibits USP3. 1 / 1
|
1
Ifosfamide affects USP3
1
|
Hsa_circ_0017639 affects USP3
|
1
Hsa-miR-98-5p affects USP3
1
|
Hsa-miR-93-5p affects USP3
1
|
Hsa-miR-337-3p affects USP3
1
|
Hsa-miR-26a-5p affects USP3
1
|
Hsa-miR-20b-5p affects USP3
1
|
Hsa-miR-202-5p affects USP3
1
|
Hsa-miR-195-5p affects USP3
1
|
Hsa-miR-18a-3p affects USP3
1
|
Hsa-miR-17-5p affects USP3
1
|
Hsa-miR-16-5p affects USP3
1
|
Hsa-miR-15a-5p affects USP3
1
|
Hsa-miR-106b-5p affects USP3
1
|
Folic acid affects USP3
1
|
Fenofibrate affects USP3
1
|
Cyanocob(III)alamin affects USP3
|
1
Cyanocob(III)alamin inhibits USP3. 1 / 1
|
1
Coumestrol affects USP3
1
|
Chloroacetaldehyde affects USP3
1
|
Beta-lapachone affects USP3
1
|
Benzo[a]pyrene affects USP3
1
|
Benzo[a]pyrene diol epoxide I affects USP3
1
|
Bafilomycin A1 affects USP3
|
1
Bafilomycin A1 increases the amount of USP3. 1 / 1
|
1
Arsenous acid affects USP3
1
|
Antirheumatic drug affects USP3
1
|
ZnF-UBP affects USP3
|
1
Vif affects USP3
|
1
USP3-AS1 affects USP3
|
1
USP3 affects ‐1β
|
1
USP3 affects γ-H2AX
|
1
USP3 affects ubiquitination TRAF6
|
1
USP3 affects uH2B protein
|
1
reach
"The downregulation of USP3 significantly elevates uH2A and uH2B protein levels, leading to functional consequences such as replication stress, abnormal DNA replication and/or recombination, delayed S‐phase progression, accumulation of DNA breaks, and hyperactivation of ATR/ATM‐regulated checkpoint responses."
USP3 affects signaling
|
1
USP3 affects signal transduction
|
1
USP3 bound to TRAF6 inhibits signal transduction. 1 / 1
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1
USP3 affects sensitized response
|
1
USP3 affects secondary metabolic process
|
1
USP3 activates secondary metabolic process. 1 / 1
|
1
reach
"Since USPs can respond to various stresses and enable cell self-adjustment for survival [40], we speculated that USP3 and USP8 could redistribute metabolic fluxes and induce more energy consumption such as ATP and NADPH to cope with stresses, thereby affecting the secondary metabolism."
USP3 affects retinoic acid
|
1
USP3 inhibits retinoic acid. 1 / 1
|
1
USP3 affects proteasome complex disassembly
|
1
USP3 activates proteasome complex disassembly. 1 / 1
|
1
USP3 affects phorbol 13-acetate 12-myristate
|
1
USP3 activates phorbol 13-acetate 12-myristate. 1 / 1
|
1
USP3 affects peptidase activity
|
1
USP3 binds peptidase activity. 1 / 1
|
1
USP3 affects pathogenesis
|
1
USP3 activates pathogenesis. 1 / 1
|
1
USP3 affects migration
|
1
USP3 affects microRNA-146-5p
|
1
USP3 affects miR-224-5p
|
1
USP3 affects miR-1245b-5p
|
1
USP3 affects localization
|
1
USP3 inhibits localization. 1 / 1
|
1
USP3 affects hyper-ubiquitination H2A H2B
|
1
USP3 affects hsa_circ_0017639
|
1
USP3 affects histones H2B
|
1
USP3 affects hemopoiesis
|
1
USP3 activates hemopoiesis. 1 / 1
|
1
USP3 affects have interaction RIG-I
|
1
USP3 affects have interaction MDA5
|
1
USP3 affects glutathione
|
1
USP3 increases the amount of glutathione. 1 / 1
|
1
USP3 affects gene expression
|
1
USP3 inhibits gene expression. 1 / 1
|
1
USP3 affects ferroptosis
|
1
USP3 activates ferroptosis. 1 / 1
|
1
USP3 affects deubiquitination snail family transcriptional
|
1
USP3 affects defense response to virus
|
1
USP3 inhibits defense response to virus. 1 / 1
|
1
USP3 affects defects
|
1
USP3 affects chondrocyte apoptosis induced interleukin IL beta
|
1
USP3 affects Ubiquitination
|
1
USP3 inhibits Ubiquitination. 1 / 1
|
1
reach
"Although we observed the existence of cytoplasmic USP3 even without LPS stimulation in USP3‐expressing THP‐1 cells, possibly due to the overexpression of USP3, LPS pretreatment still increased the amount of cytoplasmic USP3 in these cells (Fig EV5C), indicating that LPS‐pretreatment induces the cytoplasmic retention of both endogenous and exogenous USP3 in THP‐1 cells."
USP3 affects TNMs to 31.1 ± 2.3 mg/L
|
1
USP3 affects RNA binding motif
|
1
USP3 inhibits RNA binding motif. 1 / 1
|
1
sparser
"We further show that there is no interaction between USP3 and RIG-I-like receptors (RLRs) in unstimulated or uninfected cells, but upon viral infection or ligand stimulation, USP3 binds to the caspase activation recruitment domain of RLRs and then cleaves polyubiquitin chains through cooperation of its zinc-finger Ub-binding domain and USP catalytic domains."
USP3 affects RIG-I-MAVS
|
1
USP3 affects RBPs
|
1
USP3 affects MYCN protein stability
|
1
USP3 affects MKN-28 MGC-803 cell
|
1
USP3 affects LPS with O-antigen
|
1
USP3 activates LPS with O-antigen. 1 / 1
|
1
USP3 affects K882
|
1
USP3 affects K-63-linked ubiquitination MYCN
|
1
USP3 affects K-48
|
1
USP3 affects IL-1beta-mediated chondrocyte senescence
|
1
USP3 affects IL-1beta-induced chondrocyte apoptosis
|
1
USP3 affects IKK_complex
|
1
USP3 leads to the dephosphorylation of IKK_complex. 1 / 1
|
1
USP3 affects Histone_H2A
|
1
USP3 deubiquitinates Histone_H2A on K13. 1 / 1
|
1
USP3 affects H2BK120ub
|
1
USP3 affects H2AK13/15ub
|
1
USP3 affects H2AK119ub
|
1
USP3 affects Genomic Instability
|
1
USP3 inhibits Genomic Instability. 1 / 1
|
1
USP3 affects GBM progress
|
1
USP3 affects DNA damage checkpoint signaling
|
1
USP3 activates DNA damage checkpoint signaling. 1 / 1
|
1
USP3 affects Cui et al., 2014
|
1
USP3 affects Cell Survival
|
1
USP3 activates Cell Survival. 1 / 1
|
1
USP3 affects Cdc25A protein
|
1
sparser
"We further show that there is no interaction between USP3 and RIG-I-like receptors (RLRs) in unstimulated or uninfected cells, but upon viral infection or ligand stimulation, USP3 binds to the caspase activation recruitment domain of RLRs and then cleaves polyubiquitin chains through cooperation of its zinc-finger Ub-binding domain and USP catalytic domains."
USP3 affects CARD domain
|
1
USP3 affects Aurora A
|
1
USP3 affects ATR-CHK1
|
1
USP3 affects AC092894.1
|
1
USP3 affects PGL3-USP3 3'UTR
|
1
USP3 affects PGL3-SMAD4 3'UTR reporter constructs
|
1
RNA helicase affects USP3
|
1
RNA helicase bound to miR-1245b-5p increases the amount of USP3. 1 / 1
|
1
reach
"In addition, Jin et al. demonstrated that exosomal lncRNA SND1-IT1 secreted from GC cells not only recruited DDX54, a DEAD-box RNA helicase that binds to specific RNAs, to enhance USP3 mRNA stability, but also bound to miR-1245b-5p to upregulate USP3 expression, thus leading to SNAIL1 stabilization and inducing the malignant transformation of gastric mucosa cells [24]."
sparser
"We further show that there is no interaction between USP3 and RIG-I-like receptors (RLRs) in unstimulated or uninfected cells, but upon viral infection or ligand stimulation, USP3 binds to the caspase activation recruitment domain of RLRs and then cleaves polyubiquitin chains through cooperation of its zinc-finger Ub-binding domain and USP catalytic domains."
RBPs affects USP3
|
1
reach
"Among SNPs at the locus with
P < 1 × 10 , many have
been reported as cis-eQTLs in whole blood and other tissues
with febrile seizures risk alleles corresponding to decreased expression of
HERC1, USP3, DAPK2 and
PLEKHO2, and increased expression of
FBXL22, APH1B and RBPMS2
(Supplementary Table
5)."
Pulmonary Arterial Hypertension affects USP3
|
1
Pulmonary Arterial Hypertension activates USP3. 1 / 1
|
1
reach
"Very recently, ovarian tumor protease (OTU) deubiquitinating enzyme 3 (OTUD3), a deubiquitination enzyme, was reported to bind to MDA5 and RIG-I and ultimately remove their Lys-63-linked polyubiquitination to diminish the signal transduction of RLRs, thus inhibiting the antiviral immune response against RNA viruses (Figure 2) [108]."
Poly :C affects USP3
|
1
Poly :C HMW affects USP3
|
1
Particulate Matter affects USP3
1
|
PM2.5 affects USP3
|
1
reach
"Very recently, ovarian tumor protease (OTU) deubiquitinating enzyme 3 (OTUD3), a deubiquitination enzyme, was reported to bind to MDA5 and RIG-I and ultimately remove their Lys-63-linked polyubiquitination to diminish the signal transduction of RLRs, thus inhibiting the antiviral immune response against RNA viruses (Figure 2) [108]."
Neuroblastoma affects USP3
|
1
Neuroblastoma increases the amount of USP3. 1 / 1
|
1
L-methionine affects USP3
1
|
K882 affects USP3
|
1
K63 affects polyubiquitin
|
1
Hsa_circ_0017639 affects USP3
|
1
Histone_H2B affects USP3
|
1
USP3 binds Histone_H2B. 1 / 1
|
1
HOXA-AS3 affects USP3
|
1
reach
"In the USP5 structure, there is a
close π-stacking interaction between the pyridine moieties of
ZQ1 and Y259, which is analogous to the HDX-supported 59/USP3 Y94 interaction discussed above.Compound 59 binds USP3 with a K of around 14 μM,
which would not be sufficient for
a traditional occupancy-based competitor."
Gentamicins affects USP3
1
|
Enterolactone affects USP3
1
|
sparser
"We further show that there is no interaction between USP3 and RIG-I-like receptors (RLRs) in unstimulated or uninfected cells, but upon viral infection or ligand stimulation, USP3 binds to the caspase activation recruitment domain of RLRs and then cleaves polyubiquitin chains through cooperation of its zinc-finger Ub-binding domain and USP catalytic domains."
CARD domain affects polyubiquitin chains
|
1
reach
"Among SNPs at the locus with
P < 1 × 10 , many have
been reported as cis-eQTLs in whole blood and other tissues
with febrile seizures risk alleles corresponding to decreased expression of
HERC1, USP3, DAPK2 and
PLEKHO2, and increased expression of
FBXL22, APH1B and RBPMS2
(Supplementary Table
5)."
AC092894.1 affects USP3
|
1
6-propyl-2-thiouracil affects USP3
1
|
1
|
17beta-estradiol affects USP3
1
|
17alpha-ethynylestradiol affects USP3
1
|
1,2-dimethylhydrazine affects USP3
1
|