IndraLab

Statements

USP27X affects CBX2
6 | 23 3
USP27X binds CBX2.
6 | 10 3
USP27X binds CBX2. 10 / 16
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"Our findings indicate that USP27X truncating mutants lacking the USP domain do not bind CBX2, and that absence of the D1 domain in CBX2 disrupts the binding between USP27X and CBX2 (Fig. 1I–L)."
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"Therefore, the interaction between USP27X and CBX2 requires the presence of the USP domain in USP27X and the D1 domain in CBX2."
38030604
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"The interaction between USP27X and CBX2 suggests that USP27X may act as a deubiquitinating enzyme targeting the degradation of CBX2 protein."
38030604
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"The upregulation of GSK3β in BT549 cells intensified the association between endogenous USP27X and CBX2 (Fig. 5F), whereas the downregulation of GSK3β in MDA-MB-231 and MCF7 cells weakened the interaction between endogenous USP27X and CBX2 (Fig. 5G, H)."
38030604
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"For example, glycogen synthase kinase 3 beta (GSK3β) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 (Xing et al. 2023)."
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"Furthermore, it has been revealed that glycogen synthase kinase 3 beta (GSK3beta) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 and leading to further stabilization of the CBX2 protein."
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38030604
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38030604
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38030604
USP27X binds CBX2. 3 / 3
| 3
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"To evaluate the clinical significance of the USP27X-CBX2 axis and its relevance in BC, we investigated the correlation between USP27X and CBX2 protein expression in human BC specimens."
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"This phosphorylation event enhances the stability of USP27X-CBX2 interaction, thereby promoting CBX2 protein accumulation."
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"The upregulation of GSK3β in BT549 cells intensified the association between endogenous USP27X and CBX2 (Fig. xref ), whereas the downregulation of GSK3β in MDA-MB-231 and MCF7 cells weakened the interaction between endogenous USP27X and CBX2 (Fig. xref G, xref )."
38030604
USP27X activates CBX2.
| 5
USP27X activates CBX2. 5 / 5
| 5
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"USP27X enhances CBX2 protein stability."
38030604
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"Similarly, MG132 counteracted the upregulation of CBX2 caused by USP27X overexpression (Fig. 2G, H)."
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"USP27X promotes the proliferation, invasion, and metastasis of BC cells by up-regulating CBX2."
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"As anticipated, the capacity of USP27X mimetic phosphorylation-inactivated phenotype (USP27X S135A) to sustain CBX2 stability was significantly diminished compared to that of USP27X, while the ability of USP27X mimetic phosphorylation-activated phenotype (USP27X S135Q) to maintain CBX2 stability was considerably augmented (Fig. 5L, M)."
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"We have demonstrated that the overexpression of USP27X results in an increase in CBX2 levels through deubiquitination, while the deficiency of USP27X promotes CBX2 degradation and restrains tumorigenesis."
38030604
USP27X increases the amount of CBX2.
| 4
USP27X increases the amount of CBX2. 4 / 4
| 4
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"The results showed that USP27X knockdown increased endogenous CBX2 ubiquitination, while USP27X overexpression decreased CBX2 ubiquitination levels (Fig. 3A, B)."
38030604
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"One of the key findings in our study is that overexpression of USP27X significantly enhances the level of CBX2 through deubiquitination."
38030604
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"Overexpression of USP27X significantly enhances CBX2 levels by promoting deubiquitination, while deficiency of USP27X leads to CBX2 degradation, thereby inhibiting tumorigenesis."
38030604
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"As expected, treatment with the proteasome inhibitor MG132 effectively restored the decreased levels of CBX2 induced by USP27X knockdown, while inhibition of autophagy-lysosomal pathway with CQ failed to exhibit such a restorative effect (Fig. 2F)."
38030604
USP27X deubiquitinates CBX2.
| 2
USP27X deubiquitinates CBX2. 2 / 2
| 2
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"The results showed that USP27X knockdown increased endogenous CBX2 ubiquitination, while USP27X overexpression decreased CBX2 ubiquitination levels (Fig. 3A, B)."
38030604
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"USP27X deubiquitinates CBX2."
38030604
USP27X ubiquitinates CBX2.
| 1
USP27X leads to the ubiquitination of CBX2. 1 / 1
| 1
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"The results showed that USP27X knockdown increased endogenous CBX2 ubiquitination, while USP27X overexpression decreased CBX2 ubiquitination levels (Fig. 3A, B)."
38030604
USP27X decreases the amount of CBX2.
| 1
USP27X decreases the amount of CBX2. 1 / 1
| 1
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"The results showed that USP27X knockdown increased endogenous CBX2 ubiquitination, while USP27X overexpression decreased CBX2 ubiquitination levels (Fig. 3A, B)."
38030604
USP27X affects BCL2L11
5 1 | 22 1
USP27X deubiquitinates BCL2L11.
1 | 8
USP27X deubiquitinates BCL2L11. 8 / 8
1 | 7
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"In addition, ODN dramatically inhibited ubiquitination of Bim, but KD of USP27x blocked ODN-induced deubiquitination of Bim (Fig. 4H)."
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"Moreover, USP27 deubiquitinates and stabilizes the BH3-only protein Bim, subsequently enhancing apoptosis [14]."
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"Here, we report the identification of a deubiquitinase, <span class="match term0">Usp27x</span>, that binds <span class="match term1">Bim</span> upon its ERK-dependent phosphorylation and can upregulate its expression levels."
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"For example, Weber et al. found that wild-type USP27 can reduce the levels of Bim ubiquitination and stabilize Bim in response to the Raf‐ERK‐degradation signal [14]."
35018513
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"Overexpression of USP27x reduced ERK-dependent BIM phosphorylation and ubiquitination in PMA-stimulated cells as well as tumor cells with a constitutively active Raf/ERK pathway."
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"Furthermore, KD of USP27x blocked ODN-induced Bim expression and deubiquitination of Bim (Fig. 4G and H)."
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"Overexpression of USP27x combined with ERK1/2 activation to promote the deubiquitylation and stabilisation of BIM and increase caspase‐dependent apoptosis."
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"Thus, Usp27x can trigger via its proteolytic activity the deubiquitination of Bim and enhance its levels, counteracting the anti-apoptotic effects of ERK activity, and therefore acts as a tumour suppressor."
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Modified USP27X leads to the deubiquitination of BCL2L11. 1 / 1
| 1
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"Overexpression of Usp27x reduces ERK dependent Bim ubiquitination, stabilizes phosphorylated Bim, and induces apoptosis in PMA stimulated cells, as well as in tumour cells with a constitutively active Raf and ERK pathway."
27013495
USP27X binds BCL2L11.
5 | 3 1
BCL2L11 binds USP27X. 9 / 9
5 | 3 1
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"Binding of USP27x to BIM was dependent on the 42-101 amino acid region on BIM, as mutation of these sites on BIM disrupted binding to USP27x. xref Interestingly, binding of USP27x and βTrCP to BIM is independent, as knockdown of βTrCP did not reduce the association of BIM with USP27x."
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"Binding of USP27x to BIM was dependent on the 42-101 amino acid region on BIM, as mutation of these sites on BIM disrupted binding to USP27x."
37584295
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"USP27x, acting as a tumor suppressor, could bind to Bim upon its anti-apoptotic ERK dependent phosphorylation and counteract the following proteasomal degradation via its deubiquitinase activity."
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"Furthermore, like βTrCP1/2, the binding of USP27x to BIM was dependent upon ERK1/2 activation."
28548464
USP27X inhibits BCL2L11.
| 3
USP27X inhibits BCL2L11. 3 / 3
| 3
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"These data suggested that Raptor downregulation-mediated mitochondrial ROS production is critical for the enhancement of ODN-induced anti-cancer drugs sensitivity via USP27x-mediated Bim stabilization.3.7 Combined treatment with ODN and TRAIL reduces tumor growth in vivo."
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"USP27x DUB antagonizes the Raf-ERK Bim degradation pathway thus stabilizing Bim expression."
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"Loss of endogenous Usp27x enhances the Bim degrading activity of oncogenic Raf."
27013495
USP27X activates BCL2L11.
| 3
USP27X activates BCL2L11. 3 / 3
| 3
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"Cathepsin K inhibition-induced mitochondrial ROS enhances sensitivity of cancer cells to anti-cancer drugs through USP27x-mediated Bim protein stabilization."
31901727
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"Our previous study suggested that cathepsin K inhibition enhances anti-cancer drug-induced apoptotic cell death through the upregulation of USP27x-mediated Bim pro-apoptotic protein [12]."
37330581
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"USP27x had no affect the phosphorylation of Bim, but increases stability of Bim by inhibition of ubiquitination [41]."
31901727
USP27X ubiquitinates BCL2L11.
| 2
USP27X leads to the ubiquitination of BCL2L11. 2 / 2
| 2
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"In addition, ODN dramatically inhibited ubiquitination of Bim, but KD of USP27x blocked ODN-induced deubiquitination of Bim (Fig. 4H)."
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"Furthermore, KD of USP27x blocked ODN-induced Bim expression and deubiquitination of Bim (Fig. 4G and H)."
31901727
USP27X decreases the amount of BCL2L11.
| 2
USP27X decreases the amount of BCL2L11. 2 / 2
| 2
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"Furthermore, KD of USP27x blocked ODN-induced Bim expression and deubiquitination of Bim (Fig. 4G and H)."
31901727
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"For example, Weber et al. found that wild-type USP27 can reduce the levels of Bim ubiquitination and stabilize Bim in response to the Raf‐ERK‐degradation signal [14]."
35018513
USP27X dephosphorylates BCL2L11.
| 1
USP27X leads to the dephosphorylation of BCL2L11. 1 / 1
| 1
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"Overexpression of USP27x reduced ERK-dependent BIM phosphorylation and ubiquitination in PMA-stimulated cells as well as tumor cells with a constitutively active Raf/ERK pathway."
37584295
USP27X affects CCND1
1 | 23
USP27X binds CCND1.
1 | 6
USP27X binds CCND1. 7 / 7
1 | 6
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36001804
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"USP27X binds to and stabilizes CCND1 in a catalytically-dependent manner by negatively regulating its ubiquitination."
36001804
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"Future studies will elucidate at what stage and in which cellular compartment USP27X interacts with and stabilizes CCND1 and whether additional cofactors or posttranslational modifications are required to facilitate its activity toward this protein."
36001804
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"Here, we demonstrate that USP27X interacts with and stabilizes the proto-oncogene CCND1."
36001804
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"USP27X interacts with and stabilizes CCND1."
36001804
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"As USP27X would need to physically interact with CCND1 in order to stabilize it, we next tested whether USP27X binds CCND1."
36001804
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"Not only does USP27X bind to CCND1, but USP27X catalytic activity is required for reduction of CCND1 ubiquitination levels and protein stability independent of phosphorylation in cancer cells."
36001804
USP27X decreases the amount of CCND1.
| 6
USP27X decreases the amount of CCND1. 6 / 6
| 6
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"Ablation of USP27X in xenograft tumors reduces CCND1 levels and impairs growth.."
36001804
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"Hence, we next tested whether USP27X ablation, which reduces CCND1 levels, would resensitize HER2 therapy resistant cells to targeted therapy."
36001804
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"Moreover, ablation of USP27X drastically reduces CCND1 levels in these cells and arrests their growth in an Rb1-dependent manner."
36001804
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"The ablation of USP27X markedly reduces CCND1 levels and enhances the sensitivity of BC cells to lapatinib [194]."
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"These experiments revealed that indeed, overexpression of WT but not catalytically inactive USP27X drastically reduces the level of CCND1 ubiquitination (Fig. 3J, compare lanes 7, 8, and 9)."
36001804
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"These data indicated that, indeed, loss of USP27X, which reduces the levels of CCND1, leads to reduction of the CCND1-CDK4/6 complexes and, therefore, loss of Rb1 phosphorylation."
36001804
USP27X increases the amount of CCND1.
| 4
USP27X increases the amount of CCND1. 4 / 4
| 4
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"These experiments demonstrated that the expression of WT but not catalytically inactive USP27X can restore the levels of CCND1 in depleted cells (Fig. 3G, compare lanes 2, 3, and 4)."
36001804
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"The expression of exogenous WT USP27X only increased CCND1 levels slightly above the levels in non-depleted, vector only cells (Fig. 3G, lane1)."
36001804
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"As expected, USP27X depletion substantially reduced both CCND1 levels and Rb1 phosphorylation in these cells (Fig. 5E, compare lane 1 to 2)."
36001804
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"These data indicated that, indeed, loss of USP27X, which reduces the levels of CCND1, leads to reduction of the CCND1-CDK4/6 complexes and, therefore, loss of Rb1 phosphorylation."
36001804
USP27X deubiquitinates CCND1.
| 4
USP27X deubiquitinates CCND1. 4 / 4
| 4
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"As shown in Figure 3D, USP27X depletion led to a substantial increase in CCND1 ubiquitination (Fig. 3D compare lane 9 to 10)."
36001804
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"To test if USP27X can deubiquitinate CCND1 in cells, we overexpressed WT or CS USP27X in JIMT-1 cells, treated with MG132 to block proteasomal degradation, and monitored CCND1 ubiquitination after protein immunoprecipitation (Fig. 3J)."
36001804
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"These experiments revealed that indeed, overexpression of WT but not catalytically inactive USP27X drastically reduces the level of CCND1 ubiquitination (Fig. 3J, compare lanes 7, 8, and 9)."
36001804
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"Overexpression of USP27X reduces CCND1 ubiquitination and stabilizes the protein, while USP27X ablation reduces CCND1 stability."
36001804
USP27X ubiquitinates CCND1.
| 1
USP27X leads to the ubiquitination of CCND1. 1 / 1
| 1
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"Next, we sought to test whether USP27X ablation leads to increased CCND1 ubiquitination."
36001804
USP27X inhibits CCND1.
| 1
USP27X inhibits CCND1. 1 / 1
| 1
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"As expected, USP27X ablation accelerated the degradation of CCND1 (half-life of ~15 minutes in shProLuc vs. ~8 minutes in shUSP27X), confirming that CCND1 protein stability is compromised upon USP27X loss (Fig. 3E, F)."
36001804
USP27X activates CCND1.
| 1
USP27X activates CCND1. 1 / 1
| 1
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"As expected, expression of WT USP27X prolonged CCND1 stability (half-life not detected) while CS USP27X accelerated CCND1 degradation (~18 minutes vs. 15 minutes) (Fig. 3H, compare lanes 3 and 4 to 7, 8,10, 11; Fig 3I)."
36001804
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"SETD3 reverses the USP27 knockdown mediated blockade of cell proliferation."
35018513
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"These results suggest that USP27X is required to support cancer cell proliferation as opposed to regulating cell death."
36001804
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"Furthermore, USP27 or SETD3 knockdown inhibits cell proliferation, cell migration and tumorigenesis, while overexpression of SETD3 in USP27-deficient HCC cells could restore cell viability."
35018513
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"Importantly, expression of WT, but not mutant USP27X, prevented the proliferation defects caused by depletion of endogenous USP27X (XREF_FIG)."
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"Knockdown of USP27 or CTCF in HCC cells considerably decreased glycolysis and proliferation, while overexpression had the opposite effect."
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"Furthermore, evidence from in vitro and in vivo studies revealed that depletion of USP27 inhibited HCC cell proliferation, invasion, metastasis and tumorigenesis, and that overexpression of SETD3 rescued this phenotype."
35018513
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"Herein, we demonstrate that USP27 regulates Cyclin E abundance to accelerate cell cycle progression, cell proliferation, and tumor cell growth as well."
29497124
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"To determine how USP27X promotes cancer cell proliferation, we first performed immunoblots comparing the expression of several cell signaling molecules."
36001804
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"Expression of WT-USP27X on its own led to slightly increased proliferation, whereas expression of the C285S mutant led to slightly reduced proliferation."
27132940
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"The finding that USP27–SETD3 axis elevates the cell proliferation and migration prompted us to imagine that they might be upregulated in hepatocellular carcinoma."
35018513
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"Importantly, expression of WT, but not mutant USP27X, prevented the proliferation defects caused by depletion of endogenous USP27X (XREF_FIG)."
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CBX2 affects USP27X
6 | 11 3
CBX2 binds USP27X.
6 | 10 3
USP27X binds CBX2. 10 / 16
6 | 10
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"Our findings indicate that USP27X truncating mutants lacking the USP domain do not bind CBX2, and that absence of the D1 domain in CBX2 disrupts the binding between USP27X and CBX2 (Fig. 1I–L)."
38030604
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"Therefore, the interaction between USP27X and CBX2 requires the presence of the USP domain in USP27X and the D1 domain in CBX2."
38030604
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"The interaction between USP27X and CBX2 suggests that USP27X may act as a deubiquitinating enzyme targeting the degradation of CBX2 protein."
38030604
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"The upregulation of GSK3β in BT549 cells intensified the association between endogenous USP27X and CBX2 (Fig. 5F), whereas the downregulation of GSK3β in MDA-MB-231 and MCF7 cells weakened the interaction between endogenous USP27X and CBX2 (Fig. 5G, H)."
38030604
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38030604
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"For example, glycogen synthase kinase 3 beta (GSK3β) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 (Xing et al. 2023)."
39522000
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"Furthermore, it has been revealed that glycogen synthase kinase 3 beta (GSK3beta) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 and leading to further stabilization of the CBX2 protein."
38030604
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38030604
USP27X binds CBX2. 3 / 3
| 3
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"To evaluate the clinical significance of the USP27X-CBX2 axis and its relevance in BC, we investigated the correlation between USP27X and CBX2 protein expression in human BC specimens."
38030604
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"This phosphorylation event enhances the stability of USP27X-CBX2 interaction, thereby promoting CBX2 protein accumulation."
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"The upregulation of GSK3β in BT549 cells intensified the association between endogenous USP27X and CBX2 (Fig. xref ), whereas the downregulation of GSK3β in MDA-MB-231 and MCF7 cells weakened the interaction between endogenous USP27X and CBX2 (Fig. xref G, xref )."
38030604
CBX2 activates USP27X.
| 1
CBX2 activates USP27X. 1 / 1
| 1
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"Specifically, while we have identified USP27X as a deubiquitinating enzyme for CBX2 through mass spectrometry analysis, a more comprehensive understanding of the specific ubiquitination sites on CBX2 targeted by USP27X would enhance our knowledge of the underlying regulatory mechanisms."
38030604
USP27X affects SETD3
4 | 14
USP27X deubiquitinates SETD3.
| 6
USP27X deubiquitinates SETD3. 5 / 5
| 5
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"USP27 inhibits the K48-linkage poly-ubiquitination of SETD3."
35018513
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"Since USP27 could deubiquitinate and stabilize SETD3, it might promote cell proliferation and migration by regulating SETD3 protein levels."
35018513
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"Similar results were obtained in the analysis of SETD3.Based on our results, we concluded that SETD3 is deubiquitinated by USP27 and its protein level is positively regulated by and correlated with USP27 expression."
35018513
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"We found that SETD3 was deubiquitinated and stabilized by USP27."
35018513
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"USP27 was able to deubiquitinate and stabilize SETD3."
35018513
USP27X-C87A deubiquitinates SETD3. 1 / 1
| 1
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"As seen in Fig. 2C, an enzyme-inactive mutant of USP27 (C87A) failed to abolish the ubiquitination of SETD3 protein compared with the wild-type (WT) USP27, implying that the DUB activity is required for USP27 to remove ubiquitin from SETD3."
35018513
USP27X binds SETD3.
4 | 1
USP27X binds SETD3. 5 / 5
4 | 1
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"To further confirm that the interaction between SETD3 and USP27 was specific, we transfected them alone or together into 293 T cells and evaluated their interaction by immunoprecipitation and western blot."
35018513
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35018513
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35018513
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35018513
USP27X activates SETD3.
| 4
USP27X activates SETD3. 4 / 4
| 4
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"Inhibition of USP27 expression impairs the pro-migratory ability of SETD3."
35018513
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"Since upregulation of SETD3 can promote liver tumorigenesis and cancer progression [12], it is possible that USP27 can also enhance metastatic phenotype by stabilizing SETD3."
35018513
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"Knockdown of USP27 by short hairpin RNA (shRNA) accelerated the degradation of SETD3 and blocked cell proliferation."
35018513
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"In conclusion, our data suggested that USP27 could positively regulate SETD3 protein stability."
35018513
USP27X increases the amount of SETD3.
| 2
USP27X increases the amount of SETD3. 2 / 2
| 2
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"As shown in Fig. 3A and B, SETD3 protein expression is significantly upregulated by cotransfection of USP27 and the half-life of the SETD3 protein is dramatically extended by USP27."
35018513
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"Furthermore, ectopic expression of USP27 upregulated endogenous SETD3 protein levels (Fig. 3C and D)."
35018513
USP27X inhibits SETD3.
| 1
USP27X inhibits SETD3. 1 / 1
| 1
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"Finally, no obvious change in the mRNA expression levels of SETD3 was observed in the Hep3B cells showing USP27 overexpression (Fig. 3K), suggesting that the regulation of SETD3 protein degradation by USP27 might occur at the post-transcriptional level."
35018513
USP27X affects ATXN7L3
12 | 4 1
USP27X binds ATXN7L3.
12 | 3 1
ATXN7L3 binds USP27X. 10 / 15
12 | 3
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26186194
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33961781
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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."
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"Like USP22, USP27X and USP51 also form complexes with ATXN7L3 and ENY2 and harbor virtually identical catalytic domains ( Atanassov et al., 2016 )."
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ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
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"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP27X deubiquitinates ATXN7L3.
| 1
USP27X deubiquitinates ATXN7L3. 1 / 1
| 1
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"Interestingly, USP27x has been reported to deubiquitinate histone H2B-K120 in vivo and in vitro as part of a complex with ATXN7L3 and ENY2 (Atanassov et al., 2016), two of the three adapter proteins that are part of the USP22 DUB module."
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USP27X affects Cyclin_E
| 15 1
USP27X activates Cyclin_E.
| 6
USP27X activates Cyclin_E. 6 / 6
| 6
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"USP27 mediated Cyclin E stabilization is involved in tumorigenesis, suggesting that targeting USP27 may represent a new therapeutic strategy to treat cancers with aberrant overexpression of Cyclin E protein."
29497124
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"XREF_FIG, catalytically inactive USP27/CA mutant failed to protect Cyclin E from degradation, implying that the DUB activity is required for USP27 mediated Cyclin E stabilization."
29497124
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"Finally, we determined whether USP27 mediated Cyclin E stability is through proteasome."
29497124
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"XREF_FIG, MG132 (proteasome inhibitor) treatment could rescue the USP27 knockdown mediated degradation of Cyclin E protein."
29497124
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"Our discovery that USP27 mediated Cyclin E stabilization implied that USP27 might modulate cell cycle and cell proliferation through Cyclin E regulation."
29497124
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"USP27 mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis."
29497124
USP27X binds Cyclin_E.
| 4 1
Cyclin_E binds USP27X. 5 / 5
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"Furthermore, USP27x interacts with cyclin E, resulting in stabilization [ xref ]."
31901727
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"To further confirm that the interaction between Cyclin E and USP27 was specific, we transfected them alone or together into HEK293T cells and evaluated their interaction by immunoprecipitation and WB."
29497124
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"In addition, we examined whether endogenous Cyclin E interacts with USP27 in the Hep3B cells."
29497124
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"The observation that USP27 interacts with and deubiquitinates Cyclin E led us to think that USP27 might involve in cell cycle progression by regulating Cyclin E stability."
29497124
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"To prevent this degradation, USP27 interacts with and deubiquitinates cyclin E [66]."
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USP27X deubiquitinates Cyclin_E.
| 3
USP27X deubiquitinates Cyclin_E. 3 / 3
| 3
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"First, USP27 interacts with and colocalizes with Cyclin E. Second, USP27 negatively regulates Cyclin E ubiquitination."
29497124
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"To prevent this degradation, USP27 interacts with and deubiquitinates cyclin E [66]."
30241373
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"The observation that USP27 interacts with and deubiquitinates Cyclin E led us to think that USP27 might involve in cell cycle progression by regulating Cyclin E stability."
29497124
USP27X inhibits Cyclin_E.
| 1
USP27X inhibits Cyclin_E. 1 / 1
| 1
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"Treatment with 5-fluorouracil (5-FU) decreases USP27x expression, and then induces degradation of cyclin E [56]."
31901727
USP27X increases the amount of Cyclin_E.
| 1
USP27X increases the amount of Cyclin_E. 1 / 1
| 1
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"Third, USP27 positively regulates Cyclin E protein level."
29497124
ATXN7L3 affects USP27X
12 | 3 1
ATXN7L3 binds USP27X. 10 / 15
12 | 3
biogrid
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26186194
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No evidence text available
33961781
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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."
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"Like USP22, USP27X and USP51 also form complexes with ATXN7L3 and ENY2 and harbor virtually identical catalytic domains ( Atanassov et al., 2016 )."
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No evidence text available
38182161
biogrid
No evidence text available
27132940
biogrid
No evidence text available
27132940
biogrid
No evidence text available
27132940
biogrid
No evidence text available
24981860
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP27X affects SNAI1
4 1 | 8
USP27X deubiquitinates SNAI1.
1 | 4
USP27X deubiquitinates SNAI1. 5 / 5
1 | 4
reach
"Another deubiquitinase, USP27X, which was activated by TGFβ, could also deubiquitinate SNAIL1."
32610184
reach
"USP27X contributes to Snail1 deubiquitination and stabilization, and transforming growth factor-β (TGF-β) is able to promote EMT by upregulating USP27X (Lambies et al., 2019)."
38174069
reach
"USP27X promotes EMT progression in tumors by deubiquitinating and stabilizing Snail1 [41]."
37894400
ubibrowser
"Here, we performed an siRNA screen and identified <span class="match term0">USP27X</span> as a deubiquitinase that increases <span class="match term1">Snail1</span> stability"
30341066
reach
"3) Does USP27X require specific cofactors to deubiquitinate Snail1?"
30613357
USP27X binds SNAI1.
4 | 1
USP27X binds SNAI1. 5 / 5
4 | 1
biogrid
No evidence text available
30341066
biogrid
No evidence text available
30341066
biogrid
No evidence text available
30341066
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No evidence text available
30341066
reach
"In TNBC, but not in HER2-positive tumors, there is a significant association between Snail1 and USP27X."
36179816
USP27X activates SNAI1.
| 2
USP27X activates SNAI1. 2 / 2
| 2
reach
"Lambies et al. showed that in breast and pancreatic cancer cell lines, TGF-β signaling during EMT contributes to cisplatin resistance by upregulating the expression of USP27X, which increases Snail1 protein stability (38)."
38592373
reach
"USP27X can be deubiquitinated in tumor cells and thus increase Snail1 stability ( Lambies et al., 2019 )."
37001578
USP27X increases the amount of SNAI1.
| 1
USP27X increases the amount of SNAI1. 1 / 1
| 1
reach
"Thus, USP27X depletion reduced SNAIL1 levels and eventually prevented TGFβ-induced EMT and fibroblast activation [ 69 ]."
32610184
USP27X affects Neoplasm Metastasis
| 1 8
reach
"Taken together, these results suggested that USP27 might promote hepatoma metastasis."
29497124
reach
"Although Cyclin E has been reported to involve in metastasis [XREF_BIBR], how USP27 promotes migration and metastasis also need further detailed exploration."
29497124
reach
"How does USP27 promote migration and metastasis?"
29497124
reach
"Furthermore, evidence from in vitro and in vivo studies revealed that depletion of USP27 inhibited HCC cell proliferation, invasion, metastasis and tumorigenesis, and that overexpression of SETD3 rescued this phenotype."
35018513
reach
"In vivo studies confirmed that USP27 knockdown suppresses HCC growth and metastasis."
39746496
reach
"USP27X promotes the proliferation, invasion, and metastasis of BC cells by up-regulating CBX2."
38030604
reach
"Knockdown of USP27X was found to decrease the incidence of lung metastases from BC cells, while overexpression of USP27X had the opposite effect (Fig. 4L)."
38030604
eidos
"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."
33466790
reach
"Instead, overexpression of USP27X‐AS1 increased tumour burden, PCNA and liver metastasis nodules (each group n = 7) (Figure 3G–K)."
38279869
USP27X affects HYCC1
| 9
USP27X activates HYCC1.
| 8
USP27X activates HYCC1. 8 / 8
| 8
reach
"Furthermore, evidence from in vitro and in vivo studies revealed that depletion of USP27 inhibited HCC cell proliferation, invasion, metastasis and tumorigenesis, and that overexpression of SETD3 rescued this phenotype."
35018513
reach
"USP27 knockdown inhibits HCC cell growth in vivo."
35018513
reach
"In vivo studies confirmed that USP27 knockdown suppresses HCC growth and metastasis."
39746496
reach
"We also found that the levels of SETD3 and USP27 increased significantly in HCC than those in the relevant adjacent tissues."
35018513
reach
"These results indicate that depletion of USP27 also inhibited HCC cell growth in vivo."
35018513
reach
"In conclusion, USP27X‐AS1 upregulated AKT protein expression by recruiting USP7 to deubiquitinate AKT.3.6 USP27X-AS1 promoted HCC progression by regulating AKT."
38279869
reach
"To verify whether USP27X‐AS1 promoted HCC progression via AKT, we transfected Flag‐AKT into USP27X‐AS1 knockdown cells and used AKT‐siRNA to interfere with AKT expression in USP27X‐AS1 overexpressed cells."
38279869
reach
"To unravel the mechanism by which USP27X‐AS1 promotes HCC, we conducted RNA‐seq on HLF cells with USP27X‐AS1 overexpression and the control counterparts."
38279869
USP27X inhibits HYCC1.
| 1
USP27X inhibits HYCC1. 1 / 1
| 1
reach
"CCK‐8 assay, EdU assay and colony‐formation assay showed that overexpression of AKT could reverse the inhibition of HCC proliferation caused by decreasing USP27X‐AS1 (Figure 6A,B,E,F,I,J and Figure S8I,K), while USP27X‐AS1 lost the ability to promote HCC proliferation upon decreasing AKT (Figure 6C,D,G,H,K,L and Figure S8J,L)."
38279869
USP27X affects ENY2
4 | 4 1
USP27X binds ENY2.
4 | 3 1
ENY2 binds USP27X. 7 / 7
4 | 3
reach
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."
27132940
biogrid
No evidence text available
27132940
biogrid
No evidence text available
24981860
reach
"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
biogrid
No evidence text available
27132940
reach
"Like USP22, USP27X and USP51 also form complexes with ATXN7L3 and ENY2 and harbor virtually identical catalytic domains ( Atanassov et al., 2016 )."
35452621
biogrid
No evidence text available
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP27X deubiquitinates ENY2.
| 1
USP27X deubiquitinates ENY2. 1 / 1
| 1
reach
"Interestingly, USP27x has been reported to deubiquitinate histone H2B-K120 in vivo and in vitro as part of a complex with ATXN7L3 and ENY2 (Atanassov et al., 2016), two of the three adapter proteins that are part of the USP22 DUB module."
34936860
GSK3B affects USP27X
2 | 6 1
GSK3B phosphorylates USP27X.
| 4 1
GSK3B phosphorylates USP27X. 4 / 4
| 4
reach
"For example, glycogen synthase kinase 3 beta (GSK3β) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 (Xing et al. 2023)."
39522000
reach
"Furthermore, it has been revealed that glycogen synthase kinase 3 beta (GSK3beta) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 and leading to further stabilization of the CBX2 protein."
38030604
reach
"GSK3beta enhances the stability of CBX2 protein by phosphorylating USP27X."
38030604
reach
"Phosphorylation of USP27X by GSK3beta maintains the stability and oncogenic functions of CBX2."
38030604
GSK3B phosphorylates USP27X. 1 / 1
| 1
sparser
"Additionally, we have discovered a direct interaction between GSK3β and USP27X, where GSK3β phosphorylates USP27X to enhance its affinity for CBX2 and further stabilize CBX2 protein levels."
38030604
GSK3B binds USP27X.
2 | 2
USP27X binds GSK3B. 4 / 4
2 | 2
biogrid
No evidence text available
38030604
biogrid
No evidence text available
38030604
reach
"For example, glycogen synthase kinase 3 beta (GSK3β) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 (Xing et al. 2023)."
39522000
reach
"Furthermore, it has been revealed that glycogen synthase kinase 3 beta (GSK3beta) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 and leading to further stabilization of the CBX2 protein."
38030604
BCL2L11 affects USP27X
5 | 3 1
BCL2L11 binds USP27X. 9 / 9
5 | 3 1
sparser
"Binding of USP27x to BIM was dependent on the 42-101 amino acid region on BIM, as mutation of these sites on BIM disrupted binding to USP27x. xref Interestingly, binding of USP27x and βTrCP to BIM is independent, as knockdown of βTrCP did not reduce the association of BIM with USP27x."
37584295
reach
"Binding of USP27x to BIM was dependent on the 42-101 amino acid region on BIM, as mutation of these sites on BIM disrupted binding to USP27x."
37584295
reach
"USP27x, acting as a tumor suppressor, could bind to Bim upon its anti-apoptotic ERK dependent phosphorylation and counteract the following proteasomal degradation via its deubiquitinase activity."
28279784
biogrid
No evidence text available
39435421
biogrid
No evidence text available
27013495
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27013495
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No evidence text available
35044632
biogrid
No evidence text available
27013495
reach
"Furthermore, like βTrCP1/2, the binding of USP27x to BIM was dependent upon ERK1/2 activation."
28548464
USP27X activates apoptotic process.
| 7
USP27X activates apoptotic process. 6 / 6
| 6
reach
"Overexpression of USP27x combined with ERK1/2 activation to promote the deubiquitylation and stabilisation of BIM and increase caspase‐dependent apoptosis."
28548464
reach
"The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis."
27013495
reach
"However, the authors also found that overexpression of USP27x combined with ERK1/2 pathway inhibition to promote apoptosis."
28548464
reach
"Finally, deletion of Usp27x reduces apoptosis in NSCLC cells treated with an EGFR inhibitor."
27013495
reach
"Weber et al. reported that USP27x stabilizes Bim and induces apoptosis [41]."
31901727
reach
"Overexpression of Usp27x induces low levels of apoptosis in melanoma and non small cell lung cancer (NSCLC) cells and substantially enhances apoptosis induced in these cells by the inhibition of ERK signalling."
27013495
Modified USP27X activates apoptotic process. 1 / 1
| 1
reach
"Overexpression of Usp27x reduces ERK dependent Bim ubiquitination, stabilizes phosphorylated Bim, and induces apoptosis in PMA stimulated cells, as well as in tumour cells with a constitutively active Raf and ERK pathway."
27013495
USP27X inhibits apoptotic process.
| 1
reach
"In addition, in NSCLC cells, depletion of USP27x reduces apoptosis when treated with an EGFR inhibitor."
28279784
USP27X affects TRIM28
2 | 1 5
USP27X binds TRIM28.
2 | 5
USP27X binds TRIM28. 7 / 7
2 | 5
sparser
"At endogenous levels, the interaction between Usp27x L and TRIM28 was detected in 293FT cells (Fig.  xref D), but not in WM1158 cells (data not shown), which express substantially less Usp27x L compared to 293FT cells (Fig.  xref B)."
35044632
sparser
"Instead, Usp27x interacted with the E3-ligase TRIM28 and reduced ubiquitination of TRIM28."
35044632
sparser
"Usp27x interacts with the E3-ubiquitin ligase TRIM28, and TRIM28 deficiency blocks Usp27x-induced loss of cFLIP L level and apoptosis induction by pIC."
35044632
sparser
"We also could not detect an interaction between endogenous Usp27x and TRIM28 in WM1158 cells (data not shown), and Usp27x-deficient WM1158 cells were not protected from pIC-induced apoptotic cell death (Fig.  xref E)."
35044632
biogrid
No evidence text available
35044632
biogrid
No evidence text available
27132940
sparser
"However, in 293FT, which express substantially more Usp27x L (Fig.  xref B), the interaction between endogenous Usp27x and TRIM28 could be observed by IP (Fig.  xref D)."
35044632
USP27X deubiquitinates TRIM28.
| 1
USP27X leads to the deubiquitination of TRIM28. 1 / 1
| 1
reach
"Instead, Usp27x interacted with the E3-ligase TRIM28 and reduced ubiquitination of TRIM28."
35044632
reach
"Taken together, these data revealed that knockdown of USP27 or SETD3 prevents liver cancer cell migration and invasion."
35018513
reach
"USP27X promotes the proliferation, invasion, and metastasis of BC cells by up-regulating CBX2."
38030604
reach
"USP27X modulates tumor chemoresistance and invasion through deubiquitination and stabilization of Snail1 XREF_BIBR."
33391500
reach
"Furthermore, evidence from in vitro and in vivo studies revealed that depletion of USP27 inhibited HCC cell proliferation, invasion, metastasis and tumorigenesis, and that overexpression of SETD3 rescued this phenotype."
35018513
reach
"Conversely, overexpression of USP27 evidently enhanced cell invasion."
29497124
reach
"Upregulation of USP27 in hepatocellular carcinoma patients leads to elevated SETD3 expression and increased cell proliferation, invasion, migration and tumorigenesis."
35018513
reach
"Transwell assay and wound‐healing assay indicated that the impaired migration and invasion ability caused by USP27X‐AS1 knockdown could be reversed by AKT overexpression (Figure 6M,N,Q,R and Figure S9A,C)."
38279869
reach
"Transwell and wound‐healing assays indicated that USP27X‐AS1 overexpression enhanced the migration and invasion abilities of HLF and Hep3B cells (Figure 2G–J and Figure S3G–J), whereas USP27X‐AS1 knockdown diminished these capabilities in MHCC97H and LM3 cells (Figure 2G–J and Figure S3G–J)."
38279869
USP27X affects CGAS
1 | 7
USP27X binds CGAS.
1 | 3
USP27X binds CGAS and K48. 3 / 3
| 3
reach
"Furthermore, the deubiquitinating enzyme USP27X associates with cGAS and eliminates K48-linked polyubiquitinated chains from cGAS, leading to the stability of cGAS (24)."
40028324
reach
"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."
31534008
reach
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."
33511009
CGAS binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
31534008
USP27X deubiquitinates CGAS.
| 3
USP27X deubiquitinates CGAS. 3 / 3
| 3
reach
"Cutting Edge : USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA Mediated Signaling."
31534008
reach
"USP27X and USP29 have a similar mechanism for the deubiquitination of cGAS, both preventing the degradation of cGAS via the proteasomal pathway by removing the K48-linked ubiquitin chain of cGAS and maintaining cGAS protein levels."
36579404
reach
"Guo et al. have reported that cGAS can be deubiquitinated by USP27X, thereby promoting the stability of cGAS protein and increasing cGAMP expression [22] ."
37478666
USP27X activates CGAS.
| 1
USP27X activates CGAS. 1 / 1
| 1
reach
"The E3 ubiquitin ligases TRIM41 and TRIM56 augment dimerization, DNA-binding activity, and cGAMP synthesis; RNF185, and the deubiquitinating enzymes USP15 and USP27X promote cGAS stability (13, 17, 19, 23, 24)."
40028324
USP27X affects AKT
| 8
USP27X activates AKT.
| 3
USP27X activates AKT. 3 / 3
| 3
reach
"Taken together, USP27X‐AS1 upregulated AKT signalling via interacting with AKT protein.3.5 USP27X-AS1 inhibited AKT proteasome degradation."
38279869
reach
"In conclusion, USP27X‐AS1 upregulated AKT protein expression by recruiting USP7 to deubiquitinate AKT.3.6 USP27X-AS1 promoted HCC progression by regulating AKT."
38279869
reach
"Results showed that USP27X‐AS1 knockdown impaired AKT protein stability (Figure 5A1,B1 and Figure S5A1,B1), while USP27X‐AS1 overexpression prolonged the half‐life of AKT (Figure 5A2,B2 and Figure S5A2,B2), suggesting that USP27X‐AS1 might inhibit AKT degradation."
38279869
USP27X increases the amount of AKT.
| 2
USP27X increases the amount of AKT. 2 / 2
| 2
reach
"All these results confirmed that USP27X‐AS1 recruited USP7 to bind AKT.Furthermore, decreasing USP7 expression using siRNAs downregulated AKT protein expression (Figure 5J and Figure S6I), while overexpression of USP7 increased AKT protein expression (Figure 5K)."
38279869
reach
"Western blot analysis showed that USP27X‐AS1 could not upregulate AKT protein expression and poly‐ubiquitination level upon USP7 deficiency (Figure 5P and Figure S6L,M)."
38279869
USP27X decreases the amount of AKT.
| 2
USP27X decreases the amount of AKT. 2 / 2
| 2
reach
"All these results confirmed that USP27X‐AS1 recruited USP7 to bind AKT.Furthermore, decreasing USP7 expression using siRNAs downregulated AKT protein expression (Figure 5J and Figure S6I), while overexpression of USP7 increased AKT protein expression (Figure 5K)."
38279869
reach
"Results showed that only MG132 could effectively restore the protein level of AKT decreased by USP27X‐AS1 knockdown (Figure 5C and Figure S5C)."
38279869
USP27X deubiquitinates AKT.
| 1
USP27X leads to the deubiquitination of AKT. 1 / 1
| 1
reach
"Mechanistically, USP27X‐AS1 enhances USP7‐mediated deubiquitination and upgrading of AKT to promote HCC progression; we also showed that SP1 binds to the promoter of USP27X‐AS1, enhances USP27X‐AS1 transcription, revealing a novel regulatory axis of SP1‐USP27X‐AS1‐USP7‐AKT in HCC."
38279869
TGFB affects USP27X
| 3 5
TGFB activates USP27X.
| 3 4
TGFB activates USP27X. 7 / 7
| 3 4
reach
"USP27X was upregulated by TGFbeta during EMT and was required for TGFbeta induced expression of Snail1 and other mesenchymal markers in epithelial cells and CAF."
30341066
eidos
"TGFbeta enhances USP27X expression that deubiquitinates and stabilizes Snail1 , which in turn induces EMT in cancer cells and activation of CAFs ."
30613357
eidos
"TGFbeta also induces USP27X expression , which increases SNAI1 stability by deubiquitination [ 55 ] ."
| PMC
reach
"In fact, DUBs involved in Snail regulation so far are shown to be induced differently, while USP27x is induced by TGF-β; DUB3/USP17L2 seems to play a role in CDK4/6-mediated activation of EMT, whereas OTUB1 is under the transcriptional regulation of oestrogen-related receptor alpha, and USP37 regulation is induced during EMT via the stimulation of the hedgehog signalling pathway."
32636467
eidos
"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."
33466790
reach
"TGFbeta activated USP27X deubiquitinase regulates cell migration and chemoresistance via stabilization of Snail1."
30341066
reach
"TGF-β upregulated USP27X during EMT, and it was essential for Snail1 and other mesenchymal markers to be expressed in epithelial cells and CAF."
36179816
TGFB increases the amount of USP27X.
| 1
TGFB increases the amount of USP27X. 1 / 1
| 1
reach
"Specifically, DUB3 was shown to respond to IL-6-stimulated transcriptional activation and stabilize Snail1 in breast cancer cells; while USP27X expression was reported to be induced by TGFβ, which assisted the upregulation of Snail1 and other mesenchymal genes ."
32968046
PIM2 affects USP27X
6 | 2
PIM2 binds USP27X.
6 |
USP27X binds PIM2. 6 / 6
6 |
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
PIM2 phosphorylates USP27X.
| 2
PIM2 phosphorylates USP27X. 2 / 2
| 2
reach
"PIM2 phosphorylates USP27X, and promotes its deubiquitylation activity for MYC, which promotes its protein stability and leads to increase HK2-mediated aerobic glycolysis in breast cancer."
38969771
reach
"Phosphorylation of USP27X by PIM2 promotes glycolysis and breast cancer progression via deubiquitylation of MYC."
38969771
ENY2 affects USP27X
4 | 3 1
ENY2 binds USP27X. 7 / 7
4 | 3
reach
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."
27132940
biogrid
No evidence text available
27132940
biogrid
No evidence text available
24981860
reach
"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
biogrid
No evidence text available
27132940
reach
"Like USP22, USP27X and USP51 also form complexes with ATXN7L3 and ENY2 and harbor virtually identical catalytic domains ( Atanassov et al., 2016 )."
35452621
biogrid
No evidence text available
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
CCND1 affects USP27X
1 | 7
CCND1 binds USP27X.
1 | 6
USP27X binds CCND1. 7 / 7
1 | 6
biogrid
No evidence text available
36001804
reach
"USP27X binds to and stabilizes CCND1 in a catalytically-dependent manner by negatively regulating its ubiquitination."
36001804
reach
"Future studies will elucidate at what stage and in which cellular compartment USP27X interacts with and stabilizes CCND1 and whether additional cofactors or posttranslational modifications are required to facilitate its activity toward this protein."
36001804
reach
"Here, we demonstrate that USP27X interacts with and stabilizes the proto-oncogene CCND1."
36001804
reach
"USP27X interacts with and stabilizes CCND1."
36001804
reach
"As USP27X would need to physically interact with CCND1 in order to stabilize it, we next tested whether USP27X binds CCND1."
36001804
reach
"Not only does USP27X bind to CCND1, but USP27X catalytic activity is required for reduction of CCND1 ubiquitination levels and protein stability independent of phosphorylation in cancer cells."
36001804
CCND1 activates USP27X.
| 1
CCND1 activates USP27X. 1 / 1
| 1
reach
"Additionally, expression of ectopic CCND1 almost completely rescued the growth defects in USP27X-depleted cells (Supplementary Fig. 5)."
36001804
TRIM28 affects USP27X
2 | 5
USP27X binds TRIM28. 7 / 7
2 | 5
sparser
"At endogenous levels, the interaction between Usp27x L and TRIM28 was detected in 293FT cells (Fig.  xref D), but not in WM1158 cells (data not shown), which express substantially less Usp27x L compared to 293FT cells (Fig.  xref B)."
35044632
sparser
"Instead, Usp27x interacted with the E3-ligase TRIM28 and reduced ubiquitination of TRIM28."
35044632
sparser
"Usp27x interacts with the E3-ubiquitin ligase TRIM28, and TRIM28 deficiency blocks Usp27x-induced loss of cFLIP L level and apoptosis induction by pIC."
35044632
sparser
"We also could not detect an interaction between endogenous Usp27x and TRIM28 in WM1158 cells (data not shown), and Usp27x-deficient WM1158 cells were not protected from pIC-induced apoptotic cell death (Fig.  xref E)."
35044632
biogrid
No evidence text available
35044632
biogrid
No evidence text available
27132940
sparser
"However, in 293FT, which express substantially more Usp27x L (Fig.  xref B), the interaction between endogenous Usp27x and TRIM28 could be observed by IP (Fig.  xref D)."
35044632
HDAC1 affects USP27X
| 2 2 3
HDAC1 inhibits USP27X. 7 / 7
| 2 2 3
sparser
"As shown in xref , hD1 inhibits the USP27x complex at >25-fold higher inhibitor concentrations and modestly inhibits the USP51 complex only at >2500-fold higher concentration than that needed to inhibit the human DUB module."
34936860
sparser
"In addition, the finding that hD1 inhibits USP27x alone as well as the USP27x/ENY2/ATXN7L3 complex suggest that hD1 inhibits DUB activity by binding directly to the catalytic domain, rather than to the ENY2 and ATXN7L3 subunits."
34936860
sparser
"Since hD1 inhibits USP27x whether or not it is in complex with the other SAGA subunits, the inhibitor likely binds directly to the catalytic USP domain."
34936860
eidos
"In addition , the finding that hD1 inhibits USP27x alone as well as the USP27x / ENY2 / ATXN7L3 complex suggest that hD1 inhibits DUB activity by binding directly to the catalytic domain , rather than to the ENY2 and ATXN7L3 subunits ."
34936860
reach
"As shown in Figure 5B, hD1 inhibits the USP27x complex at >25-fold higher inhibitor concentrations and modestly inhibits the USP51 complex only at >2500-fold higher concentration than that needed to inhibit the human DUB module."
34936860
eidos
"Since hD1 inhibits USP27x whether or not it is in complex with the other SAGA subunits , the inhibitor likely binds directly to the catalytic USP domain ."
34936860
reach
"Since hD1 inhibits USP27x whether or not it is in complex with the other SAGA subunits, the inhibitor likely binds directly to the catalytic USP domain."
34936860
USP51 affects USP27X
2 | 4
USP27X binds USP51. 2 / 2
| 2
sparser
"Interestingly, one of the USP27X and USP51 associated proteins, C1QBP, was originally described as a mitochondrial protein ( xref )."
27132940
sparser
"The reduced tumor burden upon depletion of USP27X prompted us to search the The Cancer Genome Atlas (TCGA) database to see if altered expression of USP27X or USP51 is associated with certain cancer phenotypes."
27132940
USP27X binds USP51. 2 / 2
2 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
33961781
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP27X affects cell growth
| 6
USP27X inhibits cell growth.
| 3
USP27X inhibits cell growth. 3 / 3
| 3
reach
"As shown in Figures 5I, J, L and M, expression of WT USP27X led to a significant increase in colony number, while expression of the catalytically inactive DUB suppressed cell growth in both lines."
36001804
reach
"Ablation of USP27X leads to enhanced CCND1 ubiquitination, a drastic reduction in CCND1 protein levels, and abrogated cell growth in several cancer cell lines, including HER2 therapy resistant breast cancer cells and xenograft tumors."
36001804
reach
"These experiments confirmed that ablation of USP27X strongly impairs cell growth, whereas ATXN7L3 depletion has no impact (Supplementary Fig. 1)."
36001804
USP27X activates cell growth.
| 3
USP27X activates cell growth. 3 / 3
| 3
reach
"These results indicate that depletion of USP27 also inhibited HCC cell growth in vivo."
35018513
reach
"USP27 knockdown inhibits HCC cell growth in vivo."
35018513
reach
"Herein, we demonstrate that USP27 regulates Cyclin E abundance to accelerate cell cycle progression, cell proliferation, and tumor cell growth as well."
29497124
USP27X affects USP51
2 | 4
USP27X binds USP51. 2 / 2
| 2
sparser
"Interestingly, one of the USP27X and USP51 associated proteins, C1QBP, was originally described as a mitochondrial protein ( xref )."
27132940
sparser
"The reduced tumor burden upon depletion of USP27X prompted us to search the The Cancer Genome Atlas (TCGA) database to see if altered expression of USP27X or USP51 is associated with certain cancer phenotypes."
27132940
USP27X binds USP51. 2 / 2
2 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
33961781
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP27X affects RIGI
3 1 | 2
USP27X binds RIGI.
3 |
RIGI binds USP27X. 3 / 3
3 |
biogrid
No evidence text available
32027733
biogrid
No evidence text available
32027733
biogrid
No evidence text available
32027733
USP27X deubiquitinates RIGI.
1 | 1
USP27X leads to the deubiquitination of RIGI. 2 / 2
1 | 1
reach
"Additionally, ubiquitination assays demonstrated that USP27X reduced RIG-I ubiquitination, specifically the K63-ubiquitin linkage type."
33530371
ubibrowser
"<span class="match term0">USP27X</span> negatively regulates antiviral signaling by deubiquitinating <span class="match term1">RIG-I</span>"
32027733
USP27X ubiquitinates RIGI.
| 1
USP27X leads to the ubiquitination of RIGI. 1 / 1
| 1
reach
"USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I."
32027733
USP27X affects PIM2
6 |
USP27X binds PIM2. 6 / 6
6 |
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
USP27X affects MYC
6 |
MYC binds USP27X. 6 / 6
6 |
biogrid
No evidence text available
36424410
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
USP22 affects USP27X
2 | 2 2
USP22 binds USP27X.
2 | 2
USP22 binds USP27X. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
24981860
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
USP27X binds USP22. 1 / 1
| 1
sparser
"All these results indicate that USP27X and the close homologue USP22 specifically interact and stabilize Snail1."
30341066
USP22 inhibits USP27X.
| 1
USP22 inhibits USP27X. 1 / 1
| 1
reach
"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5 associated proteins after shRNA mediated depletion of USP22 (XREF_FIG, lanes 2 and 3 and 5 and 6)."
27132940
USP22 activates USP27X.
| 1
USP22 activates USP27X. 1 / 1
| 1
reach
"Equal numbers of cells expressing shRNAs that specifically target USP27X or USP51, but not USP22 (XREF_FIG), or expressing control shRNA, were seeded and monitored for proliferation by cell counts 72 hours later."
27132940
SETD3 affects USP27X
4 | 2
SETD3 binds USP27X.
4 | 1
USP27X binds SETD3. 5 / 5
4 | 1
reach
"To further confirm that the interaction between SETD3 and USP27 was specific, we transfected them alone or together into 293 T cells and evaluated their interaction by immunoprecipitation and western blot."
35018513
biogrid
No evidence text available
35018513
biogrid
No evidence text available
35018513
biogrid
No evidence text available
35018513
biogrid
No evidence text available
35018513
SETD3 inhibits USP27X.
| 1
SETD3 inhibits USP27X. 1 / 1
| 1
reach
"Similarly, the decreased proliferation was also confirmed by Ki67 immunofluorescence staining as the proportions of Ki67-positive proliferating cells were significantly lower in USP27 or SETD3 knockdown cells, while SETD3 overexpression could increase Ki67-positive proliferating cells in USP27-deficient cells (Supplementary Fig. S2)."
35018513
MYC affects USP27X
6 |
MYC binds USP27X. 6 / 6
6 |
biogrid
No evidence text available
36424410
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
biogrid
No evidence text available
38969771
Cyclin_E affects USP27X
| 5 1
Cyclin_E binds USP27X.
| 4 1
Cyclin_E binds USP27X. 5 / 5
| 4 1
sparser
"Furthermore, USP27x interacts with cyclin E, resulting in stabilization [ xref ]."
31901727
reach
"To further confirm that the interaction between Cyclin E and USP27 was specific, we transfected them alone or together into HEK293T cells and evaluated their interaction by immunoprecipitation and WB."
29497124
reach
"In addition, we examined whether endogenous Cyclin E interacts with USP27 in the Hep3B cells."
29497124
reach
"The observation that USP27 interacts with and deubiquitinates Cyclin E led us to think that USP27 might involve in cell cycle progression by regulating Cyclin E stability."
29497124
reach
"To prevent this degradation, USP27 interacts with and deubiquitinates cyclin E [66]."
30241373
Cyclin_E inhibits USP27X.
| 1
Cyclin_E inhibits USP27X. 1 / 1
| 1
reach
"Interestingly, USP27 expression might also be regulated by Fbxw7, a well-known E3 ubiquitin ligase of Cyclin E, which interacts with and degrades USP27."
29497124
USP27X affects cell cycle
| 5
USP27X activates cell cycle. 5 / 5
| 5
reach
"Herein, we demonstrate that USP27 regulates Cyclin E abundance to accelerate cell cycle progression, cell proliferation, and tumor cell growth as well."
29497124
reach
"XREF_FIG, USP27 knockdown suppresses cell cycle progression by increasing the percentage of cells in G1/S phase but decreasing the percentage of cells in G2/M phase, similar to 5-FU treatment."
29497124
reach
"We found that USP27 knockdown suppresses cell cycle progression by increasing the percentage of cells in G0/G1 phase, which can be reversed by the addition of Cyclin E expression."
29497124
reach
"To further support our notion that USP27 promotes cell cycle progression, we detected a statistically significant reduction in the growth of Hep3B and MHCC97H cells compared with that of control cells with single stable knockdown of USP27."
29497124
reach
"The observation that USP27 promotes cell cycle progression and cell proliferation prompted us to imagine that depletion of USP27 expression might suppress tumor progression."
29497124
SNAI1 affects USP27X
4 | 1
USP27X binds SNAI1. 5 / 5
4 | 1
biogrid
No evidence text available
30341066
biogrid
No evidence text available
30341066
biogrid
No evidence text available
30341066
biogrid
No evidence text available
30341066
reach
"In TNBC, but not in HER2-positive tumors, there is a significant association between Snail1 and USP27X."
36179816
reach
"USP27X contributes to Snail1 deubiquitination and stabilization, and transforming growth factor-β (TGF-β) is able to promote EMT by upregulating USP27X (Lambies et al., 2019)."
38174069
eidos
"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."
33466790
reach
"Depletion of USP27X inhibited TGF-β-induced EMT and fibroblast activation, which is consistent with this [ 71 ]."
36179816
reach
"The inhibition of USP27X leads to Snail1 destabilization, suppresses EMT and renders tumor cells sensitive to chemotherapy (75)."
35616129
USP27X affects cell migration
| 4
USP27X activates cell migration.
| 3
reach
"Taken together, these data revealed that knockdown of USP27 or SETD3 prevents liver cancer cell migration and invasion."
35018513
reach
"Furthermore, USP27 or SETD3 knockdown inhibits cell proliferation, cell migration and tumorigenesis, while overexpression of SETD3 in USP27-deficient HCC cells could restore cell viability."
35018513
reach
"To explore the roles of the USP27–SETD3 axis in cell migration and invasion, we performed the wound-healing assay and the results showed that knockdown of SETD3 or USP27 significantly inhibited cell migration compared to that in the control cells, whereas introducing SETD3 into USP27 knockdown cells partially restored the metastatic phenotype (Fig. 6A-D)."
35018513
USP27X inhibits cell migration.
| 1
reach
"As shown in Figure S5A-D, depletion of USP27 expression significantly decreased cell migration compared with the control in Hep3B and MHCC97H cells using wound healing assay."
29497124
USP27X affects USP22
2 | 2
USP22 binds USP27X. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
24981860
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
USP27X binds USP22. 1 / 1
| 1
sparser
"All these results indicate that USP27X and the close homologue USP22 specifically interact and stabilize Snail1."
30341066
USP27X affects UBC
4 |
USP27X binds UBC. 4 / 4
4 |
biogrid
No evidence text available
38182161
biogrid
No evidence text available
29576527
biogrid
No evidence text available
27013495
biogrid
No evidence text available
38182161
USP27X affects SH3KBP1
4 |
biogrid
No evidence text available
31980649
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
27132940
USP27X affects Neoplasms
| 4
USP27X activates Neoplasms. 4 / 4
| 4
reach
"Importantly, dox-induced depletion of USP27X significantly impaired further tumor development."
36001804
reach
"The results of this study indicate that knockdown of USP27X in MDA-MB-231 cells inhibits proliferation, whereas overexpression of USP27X in BT549 cells promotes tumor growth."
38030604
reach
"In vivo experiments also demonstrated that knockdown of USP27X suppressed tumor proliferation in xenograft models (Fig. 4F–H), while overexpression of USP27X promoted tumor proliferation in BT549 xenograft models (Fig. 4I–K)."
38030604
reach
"Collectively, we revealed that USP27 exerts tumor-promoting action by modulating the USP27–SETD3 axis.Studies have validated that USP22, the USP27 homologous protein, has similar effects with USP27 [16, 21, 22]."
35018513
USP27X affects HES1
1 | 3
USP27X deubiquitinates HES1. 4 / 4
1 | 3
reach
"Another study demonstrated that USP27x, Usp22, and Usp51 deubiquitinate and stabilize Hes1 protein, a transcriptional repressor necessary for the maintenance of neural stem/progenitor cells."
38952059
reach
"We found that Hes1 was deubiquitinated and stabilized by Usp27x and its homologs ubiquitin specific protease 22 (Usp22) and ubiquitin specific protease 51 (Usp51)."
25846153
ubibrowser
"Knockdown of Usp22 shortened the half-life of <span class="match term1">Hes1</span>, delayed its oscillation, and enhanced neuronal differentiation in mouse developing brain, whereas mis-expression of <span class="match term0">Usp27x</span> reduced neuronal differentiation."
25846153
reach
"In addition, USP27 could regulate neuronal differentiation of stem cells in the developing mouse neocortex by deubiquitinating and stabilizing Hes1 [22]."
35018513
USP27X affects GSK3B
2 | 2
USP27X binds GSK3B. 4 / 4
2 | 2
biogrid
No evidence text available
38030604
biogrid
No evidence text available
38030604
reach
"For example, glycogen synthase kinase 3 beta (GSK3β) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 (Xing et al. 2023)."
39522000
reach
"Furthermore, it has been revealed that glycogen synthase kinase 3 beta (GSK3beta) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 and leading to further stabilization of the CBX2 protein."
38030604
UBC affects USP27X
4 |
USP27X binds UBC. 4 / 4
4 |
biogrid
No evidence text available
38182161
biogrid
No evidence text available
29576527
biogrid
No evidence text available
27013495
biogrid
No evidence text available
38182161
SH3KBP1 affects USP27X
4 |
biogrid
No evidence text available
31980649
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
27132940
USP27X is modified
| 4
USP27X is phosphorylated. 4 / 4
| 4
sparser
"These findings suggest that GSK3β-mediated phosphorylation of USP27X is indispensable for its binding and deubiquitination with CBX2."
38030604
sparser
"The phosphorylation of USP27X was solely observed in HEK-293T cells that were transfected with the wild-type USP27X, and not with the S135A mutant (Fig. xref )."
38030604
sparser
"Moreover, while our study highlights the role of GSK3β in phosphorylating USP27X and enhancing its affinity for CBX2, the downstream signaling events triggered by this interaction remain largely unexplored."
38030604
sparser
"GSK3β enhances the stability of CBX2 protein by phosphorylating USP27X."
38030604
GSK3 affects USP27X
| 4
GSK3 phosphorylates USP27X. 4 / 4
| 4
reach
"Our study also elucidates the involvement of GSK3β in modulating the GSK3β-USP27X-CBX2 axis, revealing that GSK3β can directly interact with and phosphorylate USP27X, thereby enhancing its binding affinity for CBX2."
38030604
reach
"For example, glycogen synthase kinase 3 beta (GSK3β) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 (Xing et al. 2023)."
39522000
reach
"These findings suggest that GSK3β-mediated phosphorylation of USP27X is indispensable for its binding and deubiquitination with CBX2."
38030604
reach
"Additionally, we have discovered a direct interaction between GSK3β and USP27X, where GSK3β phosphorylates USP27X to enhance its affinity for CBX2 and further stabilize CBX2 protein levels."
38030604
CGAS affects USP27X
1 | 3
USP27X binds CGAS and K48. 3 / 3
| 3
reach
"Furthermore, the deubiquitinating enzyme USP27X associates with cGAS and eliminates K48-linked polyubiquitinated chains from cGAS, leading to the stability of cGAS (24)."
40028324
reach
"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."
31534008
reach
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."
33511009
CGAS binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
31534008
Valproic acid affects USP27X
3 |
Valproic acid decreases the amount of USP27X.
2 |
Valproic acid decreases the amount of USP27X. 2 / 2
2 |
ctd
No evidence text available
23179753
ctd
No evidence text available
28001369
Valproic acid methylates USP27X.
1 |
Valproic acid methylates USP27X. 1 / 1
1 |
ctd
No evidence text available
29154799
USP27X activates glycolytic process. 3 / 3
| 3
reach
"Knockdown of USP27 or CTCF in HCC cells considerably decreased glycolysis and proliferation, while overexpression had the opposite effect."
39746496
reach
"USP27 promotes glycolysis and hepatocellular carcinoma progression by stabilizing PFKFB3 through deubiquitination."
39746496
reach
"Phosphorylation of USP27X by PIM2 promotes glycolysis and breast cancer progression via deubiquitylation of MYC."
38969771
USP27X affects PFKFB3
2 | 1
USP27X binds PFKFB3.
2 |
USP27X binds PFKFB3. 2 / 2
2 |
biogrid
No evidence text available
39746496
biogrid
No evidence text available
39746496
USP27X activates PFKFB3.
| 1
USP27X activates PFKFB3. 1 / 1
| 1
reach
"USP27 promotes glycolysis and hepatocellular carcinoma progression by stabilizing PFKFB3 through deubiquitination."
39746496
USP27X affects K48
| 3
USP27X binds CGAS and K48. 3 / 3
| 3
reach
"Furthermore, the deubiquitinating enzyme USP27X associates with cGAS and eliminates K48-linked polyubiquitinated chains from cGAS, leading to the stability of cGAS (24)."
40028324
reach
"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."
31534008
reach
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."
33511009
USP27X affects Histone_H2B
| 3
USP27X deubiquitinates Histone_H2B. 3 / 3
| 3
reach
"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that all three use the ATXN7L3 zinc finger to dock the H2A and H2B acidic patch in a manner similar to that shown in the structure of the yeast DUB module bound to ubiquitinated nucleosomes."
27923209
reach
"Remarkably, this inhibitor also showed greater activity on USP22 than on two other DUBs, USP27x and USP51, that also deubiquitinate histone H2B and form complexes with two of the SAGA DUB module adaptor subunits."
34936860
reach
"Furthermore, USP27X mediates histone H2B deubiquitylation, which is critical for development (Weake et al, 2008)."
38182161
USP27X affects Carcinogenesis
| 3
USP27X activates Carcinogenesis. 3 / 3
| 3
reach
"Furthermore, evidence from in vitro and in vivo studies revealed that depletion of USP27 inhibited HCC cell proliferation, invasion, metastasis and tumorigenesis, and that overexpression of SETD3 rescued this phenotype."
35018513
reach
"Furthermore, USP27 or SETD3 knockdown inhibits cell proliferation, cell migration and tumorigenesis, while overexpression of SETD3 in USP27-deficient HCC cells could restore cell viability."
35018513
reach
"Upregulation of USP27 in hepatocellular carcinoma patients leads to elevated SETD3 expression and increased cell proliferation, invasion, migration and tumorigenesis."
35018513
RIGI affects USP27X
3 |
RIGI binds USP27X. 3 / 3
3 |
biogrid
No evidence text available
32027733
biogrid
No evidence text available
32027733
biogrid
No evidence text available
32027733
PLEC affects USP27X
| 3
PLEC inhibits USP27X. 3 / 3
| 3
sparser
"Since hD1 inhibits USP27x whether or not it is in complex with the other SAGA subunits, the inhibitor likely binds directly to the catalytic USP domain."
34936860
sparser
"As shown in xref , hD1 inhibits the USP27x complex at >25-fold higher inhibitor concentrations and modestly inhibits the USP51 complex only at >2500-fold higher concentration than that needed to inhibit the human DUB module."
34936860
sparser
"In addition, the finding that hD1 inhibits USP27x alone as well as the USP27x/ENY2/ATXN7L3 complex suggest that hD1 inhibits DUB activity by binding directly to the catalytic domain, rather than to the ENY2 and ATXN7L3 subunits."
34936860
ODN affects USP27X
| 3
ODN increases the amount of USP27X. 3 / 3
| 3
reach
"As shown in Fig. 4D, ODN markedly increased USP27x expression, but not USP9x."
31901727
reach
"However, ODN only increased USP27x expression within 3 h (Fig. 4D), and KD or KO of Cat K also induced USP27x expression (Fig. 4E and F)."
31901727
reach
"Furthermore, ODN-mediated mitochondrial ROS production induced USP27x expression."
31901727
K48 affects USP27X
| 3
USP27X binds CGAS and K48. 3 / 3
| 3
reach
"Furthermore, the deubiquitinating enzyme USP27X associates with cGAS and eliminates K48-linked polyubiquitinated chains from cGAS, leading to the stability of cGAS (24)."
40028324
reach
"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."
31534008
reach
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."
33511009
Thioacetamide affects USP27X
2 |
Thioacetamide increases the amount of USP27X.
1 |
Thioacetamide increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
34492290
Thioacetamide decreases the amount of USP27X.
1 |
Thioacetamide decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
34492290
Hsa-miR-8485 affects USP27X
2 |
Hsa-miR-8485 decreases the amount of USP27X. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-552-5p affects USP27X
2 |
Hsa-miR-552-5p decreases the amount of USP27X. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-302c-5p affects USP27X
2 |
Hsa-miR-302c-5p decreases the amount of USP27X. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23824327
Bisphenol A affects USP27X
2 |
Bisphenol A increases the amount of USP27X.
1 |
Bisphenol A increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
30816183
Bisphenol A decreases the amount of USP27X.
1 |
Bisphenol A decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
25181051
Benzo[a]pyrene affects USP27X
2 |
Benzo[a]pyrene decreases the amount of USP27X. 2 / 2
2 |
ctd
No evidence text available
19770486
ctd
No evidence text available
22316170
USP27X affects Ubiquitin
| 2
USP27X inhibits Ubiquitin.
| 1
USP27X inhibits Ubiquitin. 1 / 1
| 1
reach
"In the past year, two other deubiquitinating enzymes, USP27X and USP1, have been reported to impede ubiquitin mediated degradation of Snail1 in various biological contexts XREF_BIBR, XREF_BIBR."
33391500
USP27X activates Ubiquitin.
| 1
USP27X activates Ubiquitin. 1 / 1
| 1
reach
"The overexpression of DUB ubiquitin-specific protease 27 X-Linked (USP27X) leads to the loss of the CFLAR protein and sensitizes extrinsic apoptosis in melanoma cells."
36551253
USP27X affects USP7
1 | 1
USP27X decreases the amount of USP7.
| 1
USP27X decreases the amount of USP7. 1 / 1
| 1
reach
"All these results confirmed that USP27X‐AS1 recruited USP7 to bind AKT.Furthermore, decreasing USP7 expression using siRNAs downregulated AKT protein expression (Figure 5J and Figure S6I), while overexpression of USP7 increased AKT protein expression (Figure 5K)."
38279869
USP27X binds USP7.
1 |
USP27X binds USP7. 1 / 1
1 |
biogrid
No evidence text available
38279869
USP27X affects USP27X
| 2
USP27X inhibits USP27X.
| 1
USP27X inhibits USP27X-S135A. 1 / 1
| 1
reach
"As anticipated, the capacity of USP27X mimetic phosphorylation-inactivated phenotype (USP27X S135A) to sustain CBX2 stability was significantly diminished compared to that of USP27X, while the ability of USP27X mimetic phosphorylation-activated phenotype (USP27X S135Q) to maintain CBX2 stability was considerably augmented (Fig. 5L, M)."
38030604
USP27X activates USP27X.
| 1
USP27X activates USP27X-S135Q. 1 / 1
| 1
reach
"As anticipated, the capacity of USP27X mimetic phosphorylation-inactivated phenotype (USP27X S135A) to sustain CBX2 stability was significantly diminished compared to that of USP27X, while the ability of USP27X mimetic phosphorylation-activated phenotype (USP27X S135Q) to maintain CBX2 stability was considerably augmented (Fig. 5L, M)."
38030604
USP27X affects USP
| 2
USP27X binds USP. 1 / 1
| 1
sparser
"Additionally, our findings suggest that Ser135 may be phosphorylated by GSK3β as it binds to the USP structural domain of USP27X (Supplementary Fig. xref )."
38030604
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP27X affects SLC25A5
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
38030604
USP27X affects PCNA
1 | 1
USP27X binds PCNA.
1 |
USP27X binds PCNA. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X activates PCNA.
| 1
USP27X activates PCNA. 1 / 1
| 1
reach
"Instead, overexpression of USP27X‐AS1 increased tumour burden, PCNA and liver metastasis nodules (each group n = 7) (Figure 3G–K)."
38279869
USP27X affects KLHL20
2 |
KLHL20 binds USP27X. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
USP27X affects ITCH
1 | 1
USP27X binds ITCH. 2 / 2
1 | 1
biogrid
No evidence text available
35044632
sparser
"Although we did not detect binding between Usp27x L and CHIP by co-IP, there was a clear interaction of Usp27x L with Itch and also (although less pronounced) with DTX1 (Supplementary Fig. S6B)."
35044632
USP27X affects Histone
| 2
USP27X deubiquitinates Histone. 2 / 2
| 2
reach
"Interestingly, our previous studies demonstrated that USP27X is inactive in insolation and cannot deubiquitinate histones or digest artificial substrates (such as Ub-AMC) in vitro unless bound by ATXN7L3 (23)."
36001804
reach
"Our previous work uncovered USP27X as an epigenetic modifier that deubiquitinates histone 2B (H2Bub1) and regulates gene transcription (23)."
36001804
USP27X affects H2Bub1
| 2
USP27X deubiquitinates H2Bub1. 2 / 2
| 2
reach
"Our previous work uncovered USP27X as an epigenetic modifier that deubiquitinates histone 2B (H2Bub1) and regulates gene transcription (23)."
36001804
reach
"USP22, USP27X, or USP51 require ATXN7L3 and ENY2 for their full activity and are unable to deubiquitinate H2Bub1 alone."
35806465
USP27X affects Deubiquitinase
| 2
reach
"Knockouts of additional members of the SAGA DUB modules, ATXN7L3 and ENY2, or potential USP22 replacements in the DUB module USP27X or USP51 , also did not improve reprogramming efficiency."
40102626
reach
"The overexpression of DUB ubiquitin-specific protease 27 X-Linked (USP27X) leads to the loss of the CFLAR protein and sensitizes extrinsic apoptosis in melanoma cells."
36551253
USP27X affects DNAJA2
2 |
USP27X binds DNAJA2. 2 / 2
2 |
biogrid
No evidence text available
38030604
biogrid
No evidence text available
27132940
USP27X affects DDX39A
2 |
USP27X binds DDX39A. 2 / 2
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
38030604
USP27X affects DDB1
2 |
USP27X binds DDB1. 2 / 2
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
38030604
USP27X affects CCNE1
2 |
USP27X binds CCNE1. 2 / 2
2 |
biogrid
No evidence text available
29497124
biogrid
No evidence text available
29497124
USP27X affects CASP8
2 |
USP27X binds CASP8. 2 / 2
2 |
biogrid
No evidence text available
35044632
biogrid
No evidence text available
35044632
USP27X affects AKT1
2 |
USP27X binds AKT1. 2 / 2
2 |
biogrid
No evidence text available
38279869
biogrid
No evidence text available
38279869
USP affects USP27X
| 2
USP27X binds USP. 1 / 1
| 1
sparser
"Additionally, our findings suggest that Ser135 may be phosphorylated by GSK3β as it binds to the USP structural domain of USP27X (Supplementary Fig. xref )."
38030604
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
SLC25A5 affects USP27X
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
38030604
PFKFB3 affects USP27X
2 |
USP27X binds PFKFB3. 2 / 2
2 |
biogrid
No evidence text available
39746496
biogrid
No evidence text available
39746496
KLHL20 affects USP27X
2 |
KLHL20 binds USP27X. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
ITCH affects USP27X
1 | 1
USP27X binds ITCH. 2 / 2
1 | 1
biogrid
No evidence text available
35044632
sparser
"Although we did not detect binding between Usp27x L and CHIP by co-IP, there was a clear interaction of Usp27x L with Itch and also (although less pronounced) with DTX1 (Supplementary Fig. S6B)."
35044632
DNAJA2 affects USP27X
2 |
USP27X binds DNAJA2. 2 / 2
2 |
biogrid
No evidence text available
38030604
biogrid
No evidence text available
27132940
DDX39A affects USP27X
2 |
USP27X binds DDX39A. 2 / 2
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
38030604
DDB1 affects USP27X
2 |
USP27X binds DDB1. 2 / 2
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
38030604
CCNE1 affects USP27X
2 |
USP27X binds CCNE1. 2 / 2
2 |
biogrid
No evidence text available
29497124
biogrid
No evidence text available
29497124
CASP8 affects USP27X
2 |
USP27X binds CASP8. 2 / 2
2 |
biogrid
No evidence text available
35044632
biogrid
No evidence text available
35044632
AKT1 affects USP27X
2 |
USP27X binds AKT1. 2 / 2
2 |
biogrid
No evidence text available
38279869
biogrid
No evidence text available
38279869
AKT affects USP27X
| 2
AKT activates USP27X. 2 / 2
| 2
reach
"Silencing of AKT eliminated the promoter functions of USP27X‐AS1, including migration and invasion (Figure 6O,P,S,T and Figure S9B,D)."
38279869
reach
"After treating USP27X‐AS1 knockdown or overexpression cells with MG132, AKT protein level only restored in knockdown cell lines, indicating USP27X‐AS1 inhibited AKT proteasome degradation (Figure 5D,E and Figure S5D,E)."
38279869
ΒTrCP affects USP27X
| 1
USP27X binds βTrCP. 1 / 1
| 1
reach
"Interestingly, binding of USP27x and βTrCP to BIM is independent, as knockdown of βTrCP did not reduce the association of BIM with USP27x."
37584295
Urethane affects USP27X
1 |
Urethane decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
28818685
Trovafloxacin affects USP27X
1 |
Trovafloxacin increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
35537566
Titanium dioxide affects USP27X
1 |
Titanium dioxide decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
35295148
Sunitinib affects USP27X
1 |
Sunitinib decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
31533062
Streptozocin affects USP27X
1 |
Streptozocin increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
34414639
Silver(0) affects USP27X
1 |
Silver(0) decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
26014281
Proteasome inhibitor affects USP27X
| 1
Proteasome inhibitor activates USP27X. 1 / 1
| 1
reach
"XREF_FIG, MG132 (proteasome inhibitor) treatment could rescue the USP27 knockdown mediated degradation of Cyclin E protein."
29497124
Potassium dichromate increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
23608068
Perfluorohexanesulfonic acid decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
37995155
Paracetamol affects USP27X
1 |
Paracetamol increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
33387578
Okadaic acid affects USP27X
1 |
Okadaic acid decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
38832940
Estrogen affects USP27X
1 |
Estrogen increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
33269387
Epoxiconazole affects USP27X
1 |
Epoxiconazole increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
35436446
ctd
No evidence text available
37047231
Dieldrin affects USP27X
1 |
Dieldrin increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
20584760
Dibutyl phthalate decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
21266533
Cisplatin affects USP27X
1 |
Cisplatin increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
27392435
CGAS affects USP27X
| 1
USP27X binds cGAS. 1 / 1
| 1
sparser
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48‐linked polyubiquitin chains during viral infection. [ xref ] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48‐linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV‐1 stimulation. [ xref ] Following HSV‐1 infection, USP29 knockout mice were shown to be hypersensitive to HSV‐1 and produced less type I IFNs and proinflammatory cytokines than the wildtype control."
33511009
Bisphenol F affects USP27X
1 |
Bisphenol F increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
38685157
Bis(2-ethylhexyl) phthalate decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
34319233
Baicalin affects USP27X
1 |
Baicalin decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
34414639
ZNF346 affects USP27X
1 |
USP27X binds ZNF346. 1 / 1
1 |
biogrid
No evidence text available
38030604
ZFR affects USP27X
1 |
USP27X binds ZFR. 1 / 1
1 |
biogrid
No evidence text available
38030604
ZCCHC3 affects USP27X
1 |
USP27X binds ZCCHC3. 1 / 1
1 |
biogrid
No evidence text available
38030604
YWHAG affects USP27X
1 |
USP27X binds YWHAG. 1 / 1
1 |
biogrid
No evidence text available
38030604
YTHDF1 affects USP27X
1 |
USP27X binds YTHDF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
YTHDC1 affects USP27X
1 |
USP27X binds YTHDC1. 1 / 1
1 |
biogrid
No evidence text available
38030604
YARS1 affects USP27X
1 |
USP27X binds YARS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
XRN2 affects USP27X
1 |
USP27X binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
38030604
XLID105 variants affects USP27X
| 1
XLID105 variants inhibits USP27X. 1 / 1
| 1
reach
"We demonstrated that most XLID105 variants disrupt distinct aspects of USP27X protein biology that could perturb its function."
38182161
XLID105 missense variants affects USP27X
| 1
XLID105 missense variants inhibits USP27X. 1 / 1
| 1
reach
"These data indicate that most of the XLID105 missense variants disrupt USP27X catalytic activity, which may represent a major pathogenic mechanism in this disorder.To further characterize these variants, we used a DUB activity-based probe."
38182161
WDR43 affects USP27X
1 |
USP27X binds WDR43. 1 / 1
1 |
biogrid
No evidence text available
38030604
VSIR affects USP27X
| 1
VSIR inhibits USP27X. 1 / 1
| 1
reach
"We then focused on SP1: qRT‐PCR and Western blot analysis showed that siSP1 decreased USP27X‐AS1 expression, and vice versa (Figure 7E–H and Figure S10A–D)."
38279869
VN1R5 affects USP27X
1 |
USP27X binds VN1R5. 1 / 1
1 |
biogrid
No evidence text available
38030604
VDAC2 affects USP27X
1 |
USP27X binds VDAC2. 1 / 1
1 |
biogrid
No evidence text available
38030604
UTP3 affects USP27X
1 |
USP27X binds UTP3. 1 / 1
1 |
biogrid
No evidence text available
38030604
UTP14A affects USP27X
1 |
USP27X binds UTP14A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP7 affects USP27X
1 |
USP27X binds USP7. 1 / 1
1 |
biogrid
No evidence text available
38279869
USP51 affects USP22
| 1
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
USP51 affects USP
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP27X
1 |
USP27X binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects βTrCP
| 1
USP27X binds βTrCP. 1 / 1
| 1
reach
"Interestingly, binding of USP27x and βTrCP to BIM is independent, as knockdown of βTrCP did not reduce the association of BIM with USP27x."
37584295
USP27X affects ~3
| 1
USP27X inhibits ~3. 1 / 1
| 1
reach
"USP27X-depleted tumors weighed ~3 fold less than control tumors (Supplementary Fig. 4)."
36001804
USP27X affects stabilization Bim
| 1
USP27X activates stabilization Bim. 1 / 1
| 1
eidos
"Weber et al. reported that USP27x induced stabilization of Bim [ 27 ] ."
31817696
USP27X activates signal transduction. 1 / 1
| 1
reach
"The obtained results conclusively verify that USP27X‐AS1 promotes both cell proliferation and metastasis of HCC in vivo.3.4 USP27X-AS1 regulated the PI3K-AKT signalling pathway."
38279869
USP27X activates proteasome complex disassembly. 1 / 1
| 1
reach
"Taken together, USP27X‐AS1 upregulated AKT signalling via interacting with AKT protein.3.5 USP27X-AS1 inhibited AKT proteasome degradation."
38279869
USP27X activates fibroblast activation. 1 / 1
| 1
reach
"Depletion of USP27X inhibited TGF-β-induced EMT and fibroblast activation, which is consistent with this [ 71 ]."
36179816
USP27X affects cell tumorigenesis carcinoma
| 1
USP27X activates cell tumorigenesis carcinoma. 1 / 1
| 1
eidos
"Inhibition of USP27 expression led to the downregulation of SETD3 protein level , the blockade of the cell proliferation and tumorigenesis of hepatocellular carcinoma ( HCC ) cells ."
35018513
reach
"Knockdown of Usp22 shortened the half-life of Hes1, delayed its oscillation, and enhanced neuronal differentiation in mouse developing brain, whereas mis expression of Usp27x reduced neuronal differentiation."
25846153
USP27X affects cell death
| 1
USP27X inhibits cell death. 1 / 1
| 1
reach
"Inhibition of USP27X enhanced cell death promoted by exposition to cisplatin [5], opening the possibility to use small molecules against this enzyme to restore or potentiate chemosensitivy to cisplatin or other drugs.Recently, Dub3 was also described as a deubiquitinase of Snail1 [9]."
30613357
USP27X affects cell death exposition
| 1
USP27X inhibits cell death exposition. 1 / 1
| 1
eidos
"Inhibition of USP27X enhanced cell death promoted by exposition to cisplatin [ 5 ] , opening the possibility to use small molecules against this enzyme to restore or potentiate chemosensitivy to cisplatin or other drugs ."
30613357
USP27X affects cdk-4
| 1
USP27X increases the amount of cdk-4. 1 / 1
| 1
reach
"Figure 2F confirms that USP27X loss causes a substantial reduction of CCND1, but not CCND3, CCNE1, or CDK4/6 protein levels in these cells."
36001804
USP27X affects cGAS
| 1
USP27X binds cGAS. 1 / 1
| 1
sparser
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48‐linked polyubiquitin chains during viral infection. [ xref ] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48‐linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV‐1 stimulation. [ xref ] Following HSV‐1 infection, USP29 knockout mice were shown to be hypersensitive to HSV‐1 and produced less type I IFNs and proinflammatory cytokines than the wildtype control."
33511009
USP27X affects ZNF346
1 |
USP27X binds ZNF346. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ZFR
1 |
USP27X binds ZFR. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ZCCHC3
1 |
USP27X binds ZCCHC3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects YWHAG
1 |
USP27X binds YWHAG. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects YTHDF1
1 |
USP27X binds YTHDF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects YTHDC1
1 |
USP27X binds YTHDC1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects YARS1
1 |
USP27X binds YARS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects XRN2
1 |
USP27X binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects WDR43
1 |
USP27X binds WDR43. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects VN1R5
1 |
USP27X binds VN1R5. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects VDAC2
1 |
USP27X binds VDAC2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects UTP3
1 |
USP27X binds UTP3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects UTP14A
1 |
USP27X binds UTP14A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects USP27X-AS1
| 1
USP27X increases the amount of USP27X-AS1. 1 / 1
| 1
reach
"These data proved that USP27X‐AS1 promoted HCC progression via the AKT signalling pathway.3.7 SP1 upregulated USP27X-AS1 transcription."
38279869
USP27X affects USP16
1 |
USP27X binds USP16. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects UPF1
1 |
USP27X binds UPF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects UBAP2
1 |
USP27X binds UBAP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects UBA52
1 |
USP27X binds UBA52. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects U2AF2
1 |
USP27X binds U2AF2. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects TWNK
1 |
USP27X binds TWNK. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TUFM
1 |
USP27X binds TUFM. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TUBA1B
1 |
USP27X binds TUBA1B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TUBA1A
1 |
USP27X binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TRRAP
1 |
USP27X binds TRRAP. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects TRMT6
1 |
USP27X binds TRMT6. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TRIM26
1 |
USP27X binds TRIM26. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TRAM1
1 |
USP27X binds TRAM1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TRAF6
1 |
USP27X binds TRAF6. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TRAF1
1 |
USP27X binds TRAF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TRA2B
1 |
USP27X binds TRA2B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TOP3B
1 |
USP27X binds TOP3B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TMEM200C
1 |
biogrid
No evidence text available
38030604
USP27X affects TMEM131
1 |
USP27X binds TMEM131. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TMEM121
1 |
USP27X binds TMEM121. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TIMM50
1 |
USP27X binds TIMM50. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects THRAP3
1 |
USP27X binds THRAP3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TBCEL
| 1
TBCEL binds USP27X. 1 / 1
| 1
sparser
"Furthermore, like βTrCP1/2, the binding of USP27x to BIM EL was dependent upon ERK1/2 activation."
28548464
USP27X affects TARS2
1 |
USP27X binds TARS2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects TARDBP
1 |
USP27X binds TARDBP. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects TAF9B
1 |
TAF9B binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects TADA3
1 |
TADA3 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects TADA2B
1 |
USP27X binds TADA2B. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects TACSTD2
1 |
TACSTD2 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP27X affects Snail1
| 1
USP27X deubiquitinates Snail1. 1 / 1
| 1
reach
"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [XREF_BIBR]."
33466790
USP27X affects Snail1 protein
| 1
USP27X inhibits Snail1 protein. 1 / 1
| 1
reach
"Accordingly, downregulation of USP27X decreased Snail1 protein in several tumor cell lines."
30341066
USP27X affects SYNCRIP
1 |
biogrid
No evidence text available
38030604
USP27X affects SUPT7L
1 |
SUPT7L binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects SUPT3H
1 |
SUPT3H binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects SUPT20H
1 |
SUPT20H binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects STRAP
1 |
USP27X binds STRAP. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects STIP1
1 |
USP27X binds STIP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects STAU1
1 |
USP27X binds STAU1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SSRP1
1 |
USP27X binds SSRP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SSBP1
1 |
USP27X binds SSBP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SRSF9
1 |
USP27X binds SRSF9. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SRSF5
1 |
USP27X binds SRSF5. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SRP72
1 |
USP27X binds SRP72. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SPIN1
1 |
USP27X binds SPIN1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects SPATS2L
1 |
USP27X binds SPATS2L. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SPATA7
1 |
USP27X binds SPATA7. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SP1
| 1
SP1 binds USP27X. 1 / 1
| 1
reach
"55 , 56 In this study, we confirmed that SP1 binds to the USP27X‐AS1 promoter, activating USP27X‐AS1 transcription and resulting in elevated expression in HCC tissues."
38279869
USP27X affects SNW1
1 |
USP27X binds SNW1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SNU13
1 |
USP27X binds SNU13. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SNRPE
1 |
USP27X binds SNRPE. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SNRPD2
1 |
USP27X binds SNRPD2. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects SNAI1 stability
| 1
USP27X activates SNAI1 stability. 1 / 1
| 1
eidos
"TGFbeta also induces USP27X expression , which increases SNAI1 stability by deubiquitination [ 55 ] ."
| PMC
USP27X affects SMC3
1 |
USP27X binds SMC3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SLTM
1 |
USP27X binds SLTM. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SLC25A13
1 |
USP27X binds SLC25A13. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SLC25A11
1 |
USP27X binds SLC25A11. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SLC15A3
1 |
biogrid
No evidence text available
40355756
USP27X affects SGF29
1 |
USP27X binds SGF29. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects SF1
1 |
USP27X binds SF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SDHB
1 |
USP27X binds SDHB. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SAMM50
1 |
USP27X binds SAMM50. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects SAMHD1
1 |
USP27X binds SAMHD1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RUVBL1
1 |
USP27X binds RUVBL1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects RTL10
| 1
USP27X deubiquitinates RTL10. 1 / 1
| 1
reach
"Moreover, USP27 deubiquitinates and stabilizes the BH3-only protein Bim, subsequently enhancing apoptosis [14]."
35018513
USP27X affects RRP1B
1 |
USP27X binds RRP1B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPTOR
| 1
USP27X inhibits RPTOR. 1 / 1
| 1
reach
"These data indicated that inhibition of Cat K increases Bim stabilization via up-regulation of USP27x expression.3.5 Down-regulation of raptor is a critical role for Bim stabilization in ODN -treated cells."
31901727
USP27X affects RPS26
1 |
USP27X binds RPS26. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPS24
1 |
USP27X binds RPS24. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPS15A
1 |
USP27X binds RPS15A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPS13
1 |
USP27X binds RPS13. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPS11
1 |
USP27X binds RPS11. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPP38
1 |
USP27X binds RPP38. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPP30
1 |
USP27X binds RPP30. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPLP2
1 |
USP27X binds RPLP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPL29
1 |
USP27X binds RPL29. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPL27A
1 |
USP27X binds RPL27A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPL23A
1 |
USP27X binds RPL23A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RPL21
1 |
USP27X binds RPL21. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RO60
1 |
USP27X binds RO60. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RNMT
1 |
USP27X binds RNMT. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RNF220
1 |
USP27X binds RNF220. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RNF168
| 1
USP27X activates RNF168. 1 / 1
| 1
reach
"Interestingly, the DUBs USP26 and USP27 were found to modulate RNF168 mediated protein ubiquitylation at DSB sites, preventing excessive spreading of RAP80-BRCA1, promoting association of BRCA1 with P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29499138
USP27X affects RIPK1
1 |
USP27X binds RIPK1. 1 / 1
1 |
biogrid
No evidence text available
35044632
USP27X affects RIOX2
1 |
USP27X binds RIOX2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RIG-I ubiquitination
| 1
USP27X inhibits RIG-I ubiquitination. 1 / 1
| 1
eidos
"Additionally , ubiquitination assays demonstrated that USP27X reduced RIG-I ubiquitination , specifically the K63-ubiquitin linkage type ."
33530371
USP27X affects RFC4
1 |
USP27X binds RFC4. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RDX
1 |
USP27X binds RDX. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RCN2
1 |
USP27X binds RCN2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RBMS1
1 |
USP27X binds RBMS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RBM4B
1 |
USP27X binds RBM4B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RBM39
1 |
USP27X binds RBM39. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects RBM25
1 |
USP27X binds RBM25. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects RBFOX2
1 |
USP27X binds RBFOX2. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects RBBP7
1 |
USP27X binds RBBP7. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects RBBP4
1 |
USP27X binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects RB1
| 1
USP27X leads to the phosphorylation of RB1. 1 / 1
| 1
reach
"As expected, USP27X depletion substantially reduced both CCND1 levels and Rb1 phosphorylation in these cells (Fig. 5E, compare lane 1 to 2)."
36001804
USP27X affects RAF
| 1
USP27X inhibits RAF. 1 / 1
| 1
reach
"Loss of endogenous Usp27x enhances the Bim degrading activity of oncogenic Raf."
27013495
USP27X affects Protease
| 1
USP27X activates Protease. 1 / 1
| 1
reach
"The overexpression of DUB ubiquitin-specific protease 27 X-Linked (USP27X) leads to the loss of the CFLAR protein and sensitizes extrinsic apoptosis in melanoma cells."
36551253
USP27X affects PTMA
1 |
USP27X binds PTMA. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PTBP2
1 |
USP27X binds PTBP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PSMF1
1 |
USP27X binds PSMF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PSMD1
1 |
USP27X binds PSMD1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PSMB2
1 |
USP27X binds PSMB2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PRPS2
1 |
USP27X binds PRPS2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PRPF19
1 |
USP27X binds PRPF19. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PRKACA
1 |
USP27X binds PRKACA. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PRDX4
1 |
USP27X binds PRDX4. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PPP3CB
1 |
USP27X binds PPP3CB. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PPP2R5D
1 |
USP27X binds PPP2R5D. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PPP1CA
1 |
USP27X binds PPP1CA. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PPIL2
1 |
USP27X binds PPIL2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PPIA
1 |
USP27X binds PPIA. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PPA1
1 |
USP27X binds PPA1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects POLRMT
1 |
USP27X binds POLRMT. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PLK1
| 1
USP27X increases the amount of PLK1. 1 / 1
| 1
reach
"For instance, the USP27-mediated stability of the SETD3 protein promotes PLK1 gene transcription by binding to the promoter, resulting in cell proliferation and migration and HCC tumorigenesis (42, 53)."
38272222
USP27X affects PLEKHA4
1 |
biogrid
No evidence text available
31091453
USP27X affects PKM
1 |
USP27X binds PKM. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PIP5K1A
1 |
USP27X binds PIP5K1A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PI3K-AKT
| 1
USP27X activates PI3K-AKT. 1 / 1
| 1
reach
"The obtained results conclusively verify that USP27X‐AS1 promotes both cell proliferation and metastasis of HCC in vivo.3.4 USP27X-AS1 regulated the PI3K-AKT signalling pathway."
38279869
USP27X affects PHF6
1 |
USP27X binds PHF6. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PGAM5
1 |
USP27X binds PGAM5. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PDIA4
1 |
USP27X binds PDIA4. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PDIA3
1 |
USP27X binds PDIA3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PDCD2L
1 |
USP27X binds PDCD2L. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PCMT1
1 |
USP27X binds PCMT1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PCDHGB3
1 |
biogrid
No evidence text available
38030604
USP27X affects PCBP3
1 |
USP27X binds PCBP3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PCBP1
1 |
USP27X binds PCBP1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects PBXIP1
1 |
USP27X binds PBXIP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PARP1
1 |
USP27X binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects PAICS
1 |
USP27X binds PAICS. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects PABPC4
1 |
USP27X binds PABPC4. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects Osteosarcoma
| 1
USP27X inhibits Osteosarcoma. 1 / 1
| 1
reach
"Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619."
34571917
USP27X affects NXF1
1 |
USP27X binds NXF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NTHL1
1 |
USP27X binds NTHL1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NSMCE3
1 |
USP27X binds NSMCE3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NPM1
1 |
USP27X binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects NPEPPS
1 |
USP27X binds NPEPPS. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NOP58
1 |
USP27X binds NOP58. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NOP14
1 |
USP27X binds NOP14. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NOL10
1 |
USP27X binds NOL10. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NOC4L
1 |
USP27X binds NOC4L. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NOC2L
1 |
USP27X binds NOC2L. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NME7
1 |
USP27X binds NME7. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NME1
1 |
USP27X binds NME1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NMD3
1 |
USP27X binds NMD3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NGDN
1 |
USP27X binds NGDN. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects NARS1
1 |
USP27X binds NARS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
reach
"After treating USP27X‐AS1 knockdown or overexpression cells with MG132, AKT protein level only restored in knockdown cell lines, indicating USP27X‐AS1 inhibited AKT proteasome degradation (Figure 5D,E and Figure S5D,E)."
38279869
USP27X affects Mice
| 1
USP27X inhibits Mice. 1 / 1
| 1
reach
"Knockout mice have not been generated; however, overexpression of Usp27x inhibits neurogenesis in mice (44)."
35662507
USP27X affects MYL6
1 |
USP27X binds MYL6. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MYH9
1 |
USP27X binds MYH9. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MYH10
1 |
USP27X binds MYH10. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MTHFD1L
1 |
USP27X binds MTHFD1L. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MTDH
1 |
USP27X binds MTDH. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MRPS27
1 |
USP27X binds MRPS27. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MRPS23
1 |
USP27X binds MRPS23. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MGA
1 |
USP27X binds MGA. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects MCTS1
1 |
USP27X binds MCTS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MCM7
1 |
USP27X binds MCM7. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MCM3
1 |
USP27X binds MCM3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MATR3
1 |
USP27X binds MATR3. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects MARK3
1 |
USP27X binds MARK3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects MAGOH
1 |
USP27X binds MAGOH. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects LUC7L3
1 |
USP27X binds LUC7L3. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects LUC7L2
1 |
USP27X binds LUC7L2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects LSM14B
1 |
USP27X binds LSM14B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects LSM14A
1 |
USP27X binds LSM14A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects LSM12
1 |
USP27X binds LSM12. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects LMNB2
1 |
USP27X binds LMNB2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects LAS1L
1 |
USP27X binds LAS1L. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects KRI1
1 |
USP27X binds KRI1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects KPNA1
1 |
USP27X binds KPNA1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects KLHL12
1 |
USP27X binds KLHL12. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects KLF8
1 |
KLF8 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
35140242
USP27X affects JUP
1 |
USP27X binds JUP. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects Interferon
| 1
USP27X activates Interferon. 1 / 1
| 1
reach
"Among the DUBs that interact with cGAS or MDA5, USP27X (98) and USP29 (99) stabilize cGAS and thus positively regulate IFN production and antiviral activities."
34707613
USP27X affects IPO7
1 |
USP27X binds IPO7. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects IMP3
1 |
USP27X binds IMP3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ILF3
1 |
USP27X binds ILF3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ILF2
1 |
USP27X binds ILF2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects IGKV1D-37
1 |
USP27X binds IGKV1D-37. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects IGKV1-6
1 |
USP27X binds IGKV1-6. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects IFNs
| 1
USP27X activates IFNs. 1 / 1
| 1
reach
"Hence, USP27X and USP29 promote the production of cGAMP and downstream IFNs to mediate inflammation and autoimmune responses (Guo et al., 2019; Zhang et al., 2020b)."
36579404
USP27X affects IFNB1
| 1
USP27X activates IFNB1. 1 / 1
| 1
reach
"Additionally, the activation of USP27X induces cGAMP-dependent production of IFN-β in response to cytosolic DNA [102]."
38675916
USP27X affects IFIH1
1 |
IFIH1 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
32027733
USP27X affects HSPH1
1 |
USP27X binds HSPH1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects HSPA9
1 |
USP27X binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects HSPA8
1 |
USP27X binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects HSPA5
1 |
USP27X binds HSPA5. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects HSPA1A
1 |
USP27X binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects HSP90AB1
1 |
biogrid
No evidence text available
38030604
USP27X affects HNRNPL
1 |
USP27X binds HNRNPL. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects HNRNPH2
1 |
biogrid
No evidence text available
27132940
USP27X affects HNRNPF
1 |
USP27X binds HNRNPF. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects HNRNPDL
1 |
USP27X binds HNRNPDL. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects HLF
| 1
USP27X activates HLF. 1 / 1
| 1
reach
"Transwell and wound‐healing assays indicated that USP27X‐AS1 overexpression enhanced the migration and invasion abilities of HLF and Hep3B cells (Figure 2G–J and Figure S3G–J), whereas USP27X‐AS1 knockdown diminished these capabilities in MHCC97H and LM3 cells (Figure 2G–J and Figure S3G–J)."
38279869
USP27X affects HELLS
1 |
USP27X binds HELLS. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects HCFC1
1 |
USP27X binds HCFC1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects H3C15
1 |
USP27X binds H3C15. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects H2BC3
1 |
USP27X binds H2BC3. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects H2BC10
1 |
USP27X deubiquitinates H2BC10. 1 / 1
1 |
ubibrowser
"In contrast, depletion of non-enzymatic components, ATXN7L3 or ENY2, results in increased <span class="match term1">H2Bub1</span>. These observations led us to discover two H2Bub1 DUBs, <span class="match term0">USP27X</span> and USP51, which function independently of SAGA and compete with USP22 for ATXN7L3 and ENY2 for activity."
27132940
USP27X affects H2Aub1
| 1
USP27X deubiquitinates H2Aub1. 1 / 1
| 1
reach
"As was previously shown for the USP22 DUBm, both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1 (XREF_FIG and XREF_SUPPLEMENTARY)."
27132940
USP27X affects H2AC8
1 |
USP27X binds H2AC8. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects H2AC1
1 |
USP27X binds H2AC1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects Guo
| 1
USP27X activates Guo. 1 / 1
| 1
reach
"Hence, USP27X and USP29 promote the production of cGAMP and downstream IFNs to mediate inflammation and autoimmune responses (Guo et al., 2019; Zhang et al., 2020b)."
36579404
USP27X affects GTPBP1
1 |
USP27X binds GTPBP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GTF3C5
1 |
USP27X binds GTF3C5. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GTF3C1
1 |
USP27X binds GTF3C1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GRWD1
1 |
USP27X binds GRWD1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GPBP1
1 |
USP27X binds GPBP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GMPS
1 |
USP27X binds GMPS. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GEMIN4
1 |
USP27X binds GEMIN4. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GARS1
1 |
USP27X binds GARS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GAR1
1 |
USP27X binds GAR1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects GANAB
1 |
USP27X binds GANAB. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects G3BP2
1 |
USP27X binds G3BP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects FXR2
1 |
USP27X binds FXR2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects FHL1
1 |
USP27X binds FHL1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects FAU
1 |
USP27X binds FAU. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects FASN
1 |
USP27X binds FASN. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects FARS2
1 |
USP27X binds FARS2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects FAM120C
1 |
USP27X binds FAM120C. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EWSR1
1 |
USP27X binds EWSR1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ETFA
1 |
USP27X binds ETFA. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ETF1
1 |
USP27X binds ETF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EMG1
1 |
USP27X binds EMG1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ELOB
1 |
USP27X binds ELOB. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects ELAVL2
1 |
USP27X binds ELAVL2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF6
1 |
USP27X binds EIF6. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF5AL1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF4B
1 |
USP27X binds EIF4B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF4A3
1 |
USP27X binds EIF4A3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF4A2
1 |
USP27X binds EIF4A2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF4A1
1 |
USP27X binds EIF4A1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects EIF3L
1 |
USP27X binds EIF3L. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF3G
1 |
USP27X binds EIF3G. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF3F
1 |
USP27X binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF3E
1 |
USP27X binds EIF3E. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects EIF2AK2
1 |
biogrid
No evidence text available
38030604
USP27X affects EEF1A1
1 |
USP27X binds EEF1A1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ECT2
1 |
USP27X binds ECT2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects E3-ligase tripartite motif containing 28
| 1
USP27X binds E3-ligase tripartite motif containing 28. 1 / 1
| 1
reach
"USP27X interacts with the E3-ligase tripartite motif containing 28 (TRIM28) and reduces the ubiquitination of E3-ligases TRIM28, but not ITCH and DTX1, which leads to decreased CFLAR protein [17]."
36551253
USP27X affects DTX1
1 |
USP27X binds DTX1. 1 / 1
1 |
biogrid
No evidence text available
35044632
USP27X affects DNAJC8
1 |
USP27X binds DNAJC8. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DNAJC13
1 |
USP27X binds DNAJC13. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DIMT1
1 |
USP27X binds DIMT1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DHX30
1 |
USP27X binds DHX30. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DENR
1 |
USP27X binds DENR. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DDX55
1 |
USP27X binds DDX55. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DDX54
1 |
USP27X binds DDX54. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DDX50
1 |
USP27X binds DDX50. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects DDX24
1 |
USP27X binds DDX24. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DDX17
1 |
USP27X binds DDX17. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects DCAF7
1 |
USP27X binds DCAF7. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects DARS1
1 |
USP27X binds DARS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects Cell Survival
| 1
USP27X activates Cell Survival. 1 / 1
| 1
reach
"As shown in Fig. 4A and B, USP27 knockdown markedly reduce the cell viability of Hep3B and MHCC97H cells."
35018513
USP27X affects Caspase
| 1
USP27X activates Caspase. 1 / 1
| 1
reach
"Overexpression of USP27x combined with ERK1/2 activation to promote the deubiquitylation and stabilisation of BIM and increase caspase‐dependent apoptosis."
28548464
USP27X affects CSRP2
1 |
USP27X binds CSRP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CS
1 |
USP27X binds CS. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CPSF3
1 |
USP27X binds CPSF3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CPSF1
1 |
USP27X binds CPSF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CORO1C
1 |
USP27X binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CMTR1
1 |
USP27X binds CMTR1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CLIC1
1 |
USP27X binds CLIC1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CKB
1 |
USP27X binds CKB. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CFLAR
| 1
USP27X decreases the amount of CFLAR. 1 / 1
| 1
reach
"Here, we report that enhanced expression of Usp27x in human melanoma cells leads to the loss of cellular FLICE-like inhibitory protein (cFLIP) and sensitizes to Tumor necrosis factor receptor 1 (TNF-R1) or Toll-like receptor 3 (TLR3)-induced extrinsic apoptosis through enabling enhanced processing of caspase-8."
35044632
USP27X affects CDK1
1 |
USP27X binds CDK1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CCT4
1 |
USP27X binds CCT4. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CCT2
1 |
USP27X binds CCT2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CCNB1
1 |
USP27X binds CCNB1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CBX3
1 |
USP27X binds CBX3. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects CBLN4
1 |
USP27X binds CBLN4. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects CAMK2D
1 |
USP27X binds CAMK2D. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects C8orf33
1 |
USP27X binds C8orf33. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects C1orf35
1 |
biogrid
No evidence text available
38030604
USP27X affects C1QBP
1 |
USP27X binds C1QBP. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects BYSL
1 |
USP27X binds BYSL. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects BOP1
1 |
USP27X binds BOP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects BMS1
1 |
USP27X binds BMS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects BLK
1 |
BLK binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
36736316
USP27X affects ATXN7L1
1 |
ATXN7L1 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP27X affects ATXN7
1 |
ATXN7 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP27X affects ATP5F1C
1 |
biogrid
No evidence text available
38030604
USP27X affects ATP5F1B
1 |
USP27X binds ATP5F1B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ATAD3B
1 |
USP27X binds ATAD3B. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ATAD3A
1 |
USP27X binds ATAD3A. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ARHGEF12
1 |
USP27X binds ARHGEF12. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects API5
1 |
USP27X binds API5. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ANXA5
1 |
USP27X binds ANXA5. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ANXA2P2
1 |
biogrid
No evidence text available
38030604
USP27X affects AMDHD2
1 |
USP27X binds AMDHD2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects AIMP2
1 |
USP27X binds AIMP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects AIFM1
1 |
USP27X binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP27X affects ADH5
1 |
USP27X binds ADH5. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ACLY
1 |
USP27X binds ACLY. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP27X affects ABCD3
1 |
USP27X binds ABCD3. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP22 affects USP51
| 1
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
USP16 affects USP27X
1 |
USP27X binds USP16. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP affects USP51
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
UPF1 affects USP27X
1 |
USP27X binds UPF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
UBAP2 affects USP27X
1 |
USP27X binds UBAP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
UBA52 affects USP27X
1 |
USP27X binds UBA52. 1 / 1
1 |
biogrid
No evidence text available
38030604
U2AF2 affects USP27X
1 |
USP27X binds U2AF2. 1 / 1
1 |
biogrid
No evidence text available
27132940
TWNK affects USP27X
1 |
USP27X binds TWNK. 1 / 1
1 |
biogrid
No evidence text available
38030604
TUFM affects USP27X
1 |
USP27X binds TUFM. 1 / 1
1 |
biogrid
No evidence text available
38030604
TUBA1B affects USP27X
1 |
USP27X binds TUBA1B. 1 / 1
1 |
biogrid
No evidence text available
38030604
TUBA1A affects USP27X
1 |
USP27X binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
38030604
TRRAP affects USP27X
1 |
USP27X binds TRRAP. 1 / 1
1 |
biogrid
No evidence text available
24981860
TRMT6 affects USP27X
1 |
USP27X binds TRMT6. 1 / 1
1 |
biogrid
No evidence text available
38030604
TRIM26 affects USP27X
1 |
USP27X binds TRIM26. 1 / 1
1 |
biogrid
No evidence text available
38030604
TRAM1 affects USP27X
1 |
USP27X binds TRAM1. 1 / 1
1 |
biogrid
No evidence text available
38030604
TRAF6 affects USP27X
1 |
USP27X binds TRAF6. 1 / 1
1 |
biogrid
No evidence text available
38030604
TRAF1 affects USP27X
1 |
USP27X binds TRAF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
TRA2B affects USP27X
1 |
USP27X binds TRA2B. 1 / 1
1 |
biogrid
No evidence text available
38030604
TOP3B affects USP27X
1 |
USP27X binds TOP3B. 1 / 1
1 |
biogrid
No evidence text available
38030604
TMEM200C affects USP27X
1 |
biogrid
No evidence text available
38030604
TMEM131 affects USP27X
1 |
USP27X binds TMEM131. 1 / 1
1 |
biogrid
No evidence text available
38030604
TMEM121 affects USP27X
1 |
USP27X binds TMEM121. 1 / 1
1 |
biogrid
No evidence text available
38030604
TIMM50 affects USP27X
1 |
USP27X binds TIMM50. 1 / 1
1 |
biogrid
No evidence text available
38030604
THRAP3 affects USP27X
1 |
USP27X binds THRAP3. 1 / 1
1 |
biogrid
No evidence text available
38030604
TBCEL affects USP27X
| 1
TBCEL binds USP27X. 1 / 1
| 1
sparser
"Furthermore, like βTrCP1/2, the binding of USP27x to BIM EL was dependent upon ERK1/2 activation."
28548464
TARS2 affects USP27X
1 |
USP27X binds TARS2. 1 / 1
1 |
biogrid
No evidence text available
38030604
TARDBP affects USP27X
1 |
USP27X binds TARDBP. 1 / 1
1 |
biogrid
No evidence text available
27132940
TAF9B affects USP27X
1 |
TAF9B binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
TADA3 affects USP27X
1 |
TADA3 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
TADA2B affects USP27X
1 |
USP27X binds TADA2B. 1 / 1
1 |
biogrid
No evidence text available
24981860
TACSTD2 affects USP27X
1 |
TACSTD2 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
33961781
Soman affects USP27X
1 |
Soman increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
19281266
SYNCRIP affects USP27X
1 |
biogrid
No evidence text available
38030604
SUPT7L affects USP27X
1 |
SUPT7L binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
SUPT3H affects USP27X
1 |
SUPT3H binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
SUPT20H affects USP27X
1 |
SUPT20H binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
STRAP affects USP27X
1 |
USP27X binds STRAP. 1 / 1
1 |
biogrid
No evidence text available
38030604
STIP1 affects USP27X
1 |
USP27X binds STIP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
STAU1 affects USP27X
1 |
USP27X binds STAU1. 1 / 1
1 |
biogrid
No evidence text available
38030604
SSRP1 affects USP27X
1 |
USP27X binds SSRP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
SSBP1 affects USP27X
1 |
USP27X binds SSBP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
SRSF9 affects USP27X
1 |
USP27X binds SRSF9. 1 / 1
1 |
biogrid
No evidence text available
38030604
SRSF5 affects USP27X
1 |
USP27X binds SRSF5. 1 / 1
1 |
biogrid
No evidence text available
38030604
SRP72 affects USP27X
1 |
USP27X binds SRP72. 1 / 1
1 |
biogrid
No evidence text available
38030604
SPIN1 affects USP27X
1 |
USP27X binds SPIN1. 1 / 1
1 |
biogrid
No evidence text available
27132940
SPATS2L affects USP27X
1 |
USP27X binds SPATS2L. 1 / 1
1 |
biogrid
No evidence text available
38030604
SPATA7 affects USP27X
1 |
USP27X binds SPATA7. 1 / 1
1 |
biogrid
No evidence text available
38030604
SP1.4 DISCUSSION affects USP27X
| 1
SP1.4 DISCUSSION increases the amount of USP27X. 1 / 1
| 1
reach
"Thus, binding sites 1, 2 and 3 were deemed critical to activating USP27X‐AS1 transcription by SP1.4 DISCUSSION."
38279869
SP1 affects USP27X
| 1
SP1 binds USP27X. 1 / 1
| 1
reach
"55 , 56 In this study, we confirmed that SP1 binds to the USP27X‐AS1 promoter, activating USP27X‐AS1 transcription and resulting in elevated expression in HCC tissues."
38279869
SNW1 affects USP27X
1 |
USP27X binds SNW1. 1 / 1
1 |
biogrid
No evidence text available
38030604
SNU13 affects USP27X
1 |
USP27X binds SNU13. 1 / 1
1 |
biogrid
No evidence text available
38030604
SNRPE affects USP27X
1 |
USP27X binds SNRPE. 1 / 1
1 |
biogrid
No evidence text available
38030604
SNRPD2 affects USP27X
1 |
USP27X binds SNRPD2. 1 / 1
1 |
biogrid
No evidence text available
27132940
SMC3 affects USP27X
1 |
USP27X binds SMC3. 1 / 1
1 |
biogrid
No evidence text available
38030604
SLTM affects USP27X
1 |
USP27X binds SLTM. 1 / 1
1 |
biogrid
No evidence text available
38030604
SLC25A13 affects USP27X
1 |
USP27X binds SLC25A13. 1 / 1
1 |
biogrid
No evidence text available
38030604
SLC25A11 affects USP27X
1 |
USP27X binds SLC25A11. 1 / 1
1 |
biogrid
No evidence text available
38030604
SLC15A3 affects USP27X
1 |
biogrid
No evidence text available
40355756
SGF29 affects USP27X
1 |
USP27X binds SGF29. 1 / 1
1 |
biogrid
No evidence text available
24981860
SF1 affects USP27X
1 |
USP27X binds SF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
SDHB affects USP27X
1 |
USP27X binds SDHB. 1 / 1
1 |
biogrid
No evidence text available
38030604
SAMM50 affects USP27X
1 |
USP27X binds SAMM50. 1 / 1
1 |
biogrid
No evidence text available
38030604
SAMHD1 affects USP27X
1 |
USP27X binds SAMHD1. 1 / 1
1 |
biogrid
No evidence text available
38030604
Reactive Oxygen Species increases the amount of USP27X. 1 / 1
| 1
reach
"Furthermore, ODN-mediated mitochondrial ROS production induced USP27x expression."
31901727
RUVBL1 affects USP27X
1 |
USP27X binds RUVBL1. 1 / 1
1 |
biogrid
No evidence text available
27132940
RRP1B affects USP27X
1 |
USP27X binds RRP1B. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPTOR affects USP27X
| 1
RPTOR increases the amount of USP27X. 1 / 1
| 1
reach
"In addition, overexpression of Raptor and blockers of mitochondrial ROS blocked ODN-induced USP27x expression (Fig. 6L and M)."
31901727
RPS26 affects USP27X
1 |
USP27X binds RPS26. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPS24 affects USP27X
1 |
USP27X binds RPS24. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPS15A affects USP27X
1 |
USP27X binds RPS15A. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPS13 affects USP27X
1 |
USP27X binds RPS13. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPS11 affects USP27X
1 |
USP27X binds RPS11. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPP38 affects USP27X
1 |
USP27X binds RPP38. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPP30 affects USP27X
1 |
USP27X binds RPP30. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPLP2 affects USP27X
1 |
USP27X binds RPLP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPL29 affects USP27X
1 |
USP27X binds RPL29. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPL27A affects USP27X
1 |
USP27X binds RPL27A. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPL23A affects USP27X
1 |
USP27X binds RPL23A. 1 / 1
1 |
biogrid
No evidence text available
38030604
RPL21 affects USP27X
1 |
USP27X binds RPL21. 1 / 1
1 |
biogrid
No evidence text available
38030604
RO60 affects USP27X
1 |
USP27X binds RO60. 1 / 1
1 |
biogrid
No evidence text available
38030604
RNMT affects USP27X
1 |
USP27X binds RNMT. 1 / 1
1 |
biogrid
No evidence text available
38030604
RNF220 affects USP27X
1 |
USP27X binds RNF220. 1 / 1
1 |
biogrid
No evidence text available
38030604
RIPK1 affects USP27X
1 |
USP27X binds RIPK1. 1 / 1
1 |
biogrid
No evidence text available
35044632
RIOX2 affects USP27X
1 |
USP27X binds RIOX2. 1 / 1
1 |
biogrid
No evidence text available
38030604
RFC4 affects USP27X
1 |
USP27X binds RFC4. 1 / 1
1 |
biogrid
No evidence text available
38030604
RDX affects USP27X
1 |
USP27X binds RDX. 1 / 1
1 |
biogrid
No evidence text available
38030604
RCN2 affects USP27X
1 |
USP27X binds RCN2. 1 / 1
1 |
biogrid
No evidence text available
38030604
RBMS1 affects USP27X
1 |
USP27X binds RBMS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
RBM4B affects USP27X
1 |
USP27X binds RBM4B. 1 / 1
1 |
biogrid
No evidence text available
38030604
RBM39 affects USP27X
1 |
USP27X binds RBM39. 1 / 1
1 |
biogrid
No evidence text available
27132940
RBM25 affects USP27X
1 |
USP27X binds RBM25. 1 / 1
1 |
biogrid
No evidence text available
38030604
RBFOX2 affects USP27X
1 |
USP27X binds RBFOX2. 1 / 1
1 |
biogrid
No evidence text available
27132940
RBBP7 affects USP27X
1 |
USP27X binds RBBP7. 1 / 1
1 |
biogrid
No evidence text available
27132940
RBBP4 affects USP27X
1 |
USP27X binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
27132940
PTMA affects USP27X
1 |
USP27X binds PTMA. 1 / 1
1 |
biogrid
No evidence text available
38030604
PTBP2 affects USP27X
1 |
USP27X binds PTBP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
PSMF1 affects USP27X
1 |
USP27X binds PSMF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
PSMD1 affects USP27X
1 |
USP27X binds PSMD1. 1 / 1
1 |
biogrid
No evidence text available
38030604
PSMB2 affects USP27X
1 |
USP27X binds PSMB2. 1 / 1
1 |
biogrid
No evidence text available
38030604
PRPS2 affects USP27X
1 |
USP27X binds PRPS2. 1 / 1
1 |
biogrid
No evidence text available
38030604
PRPF19 affects USP27X
1 |
USP27X binds PRPF19. 1 / 1
1 |
biogrid
No evidence text available
38030604
PRKACA affects USP27X
1 |
USP27X binds PRKACA. 1 / 1
1 |
biogrid
No evidence text available
38030604
PRDX4 affects USP27X
1 |
USP27X binds PRDX4. 1 / 1
1 |
biogrid
No evidence text available
38030604
PPP3CB affects USP27X
1 |
USP27X binds PPP3CB. 1 / 1
1 |
biogrid
No evidence text available
38030604
PPP2R5D affects USP27X
1 |
USP27X binds PPP2R5D. 1 / 1
1 |
biogrid
No evidence text available
38030604
PPP1CA affects USP27X
1 |
USP27X binds PPP1CA. 1 / 1
1 |
biogrid
No evidence text available
38030604
PPIL2 affects USP27X
1 |
USP27X binds PPIL2. 1 / 1
1 |
biogrid
No evidence text available
38030604
PPIA affects USP27X
1 |
USP27X binds PPIA. 1 / 1
1 |
biogrid
No evidence text available
38030604
PPA1 affects USP27X
1 |
USP27X binds PPA1. 1 / 1
1 |
biogrid
No evidence text available
38030604
POLRMT affects USP27X
1 |
USP27X binds POLRMT. 1 / 1
1 |
biogrid
No evidence text available
38030604
PLEKHA4 affects USP27X
1 |
biogrid
No evidence text available
31091453
PKM affects USP27X
1 |
USP27X binds PKM. 1 / 1
1 |
biogrid
No evidence text available
38030604
PIP5K1A affects USP27X
1 |
USP27X binds PIP5K1A. 1 / 1
1 |
biogrid
No evidence text available
38030604
PHF6 affects USP27X
1 |
USP27X binds PHF6. 1 / 1
1 |
biogrid
No evidence text available
38030604
PGAM5 affects USP27X
1 |
USP27X binds PGAM5. 1 / 1
1 |
biogrid
No evidence text available
38030604
PDIA4 affects USP27X
1 |
USP27X binds PDIA4. 1 / 1
1 |
biogrid
No evidence text available
38030604
PDIA3 affects USP27X
1 |
USP27X binds PDIA3. 1 / 1
1 |
biogrid
No evidence text available
38030604
PDCD2L affects USP27X
1 |
USP27X binds PDCD2L. 1 / 1
1 |
biogrid
No evidence text available
38030604
PCNA affects USP27X
1 |
USP27X binds PCNA. 1 / 1
1 |
biogrid
No evidence text available
27132940
PCMT1 affects USP27X
1 |
USP27X binds PCMT1. 1 / 1
1 |
biogrid
No evidence text available
38030604
PCDHGB3 affects USP27X
1 |
biogrid
No evidence text available
38030604
PCBP3 affects USP27X
1 |
USP27X binds PCBP3. 1 / 1
1 |
biogrid
No evidence text available
38030604
PCBP1 affects USP27X
1 |
USP27X binds PCBP1. 1 / 1
1 |
biogrid
No evidence text available
27132940
PBXIP1 affects USP27X
1 |
USP27X binds PBXIP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
PARP1 affects USP27X
1 |
USP27X binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
27132940
PAICS affects USP27X
1 |
USP27X binds PAICS. 1 / 1
1 |
biogrid
No evidence text available
38030604
PABPC4 affects USP27X
1 |
USP27X binds PABPC4. 1 / 1
1 |
biogrid
No evidence text available
38030604
NXF1 affects USP27X
1 |
USP27X binds NXF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
NTHL1 affects USP27X
1 |
USP27X binds NTHL1. 1 / 1
1 |
biogrid
No evidence text available
38030604
NSMCE3 affects USP27X
1 |
USP27X binds NSMCE3. 1 / 1
1 |
biogrid
No evidence text available
38030604
NPM1 affects USP27X
1 |
USP27X binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
27132940
NPEPPS affects USP27X
1 |
USP27X binds NPEPPS. 1 / 1
1 |
biogrid
No evidence text available
38030604
NOP58 affects USP27X
1 |
USP27X binds NOP58. 1 / 1
1 |
biogrid
No evidence text available
38030604
NOP14 affects USP27X
1 |
USP27X binds NOP14. 1 / 1
1 |
biogrid
No evidence text available
38030604
NOL10 affects USP27X
1 |
USP27X binds NOL10. 1 / 1
1 |
biogrid
No evidence text available
38030604
NOC4L affects USP27X
1 |
USP27X binds NOC4L. 1 / 1
1 |
biogrid
No evidence text available
38030604
NOC2L affects USP27X
1 |
USP27X binds NOC2L. 1 / 1
1 |
biogrid
No evidence text available
38030604
NME7 affects USP27X
1 |
USP27X binds NME7. 1 / 1
1 |
biogrid
No evidence text available
38030604
NME1 affects USP27X
1 |
USP27X binds NME1. 1 / 1
1 |
biogrid
No evidence text available
38030604
NMD3 affects USP27X
1 |
USP27X binds NMD3. 1 / 1
1 |
biogrid
No evidence text available
38030604
NGDN affects USP27X
1 |
USP27X binds NGDN. 1 / 1
1 |
biogrid
No evidence text available
38030604
NARS1 affects USP27X
1 |
USP27X binds NARS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
N-methyl-4-phenylpyridinium increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
28801915
MiR-214-5p affects USP27X
| 1
MiR-214-5p activates USP27X. 1 / 1
| 1
reach
"MiR-214-5p promotes the anti-tumor activity of NK cells by regulating the USP27X/Bim pathway, thereby inhibiting colorectal cancer (CRC) liver metastasis [35]."
40098140
MYL6 affects USP27X
1 |
USP27X binds MYL6. 1 / 1
1 |
biogrid
No evidence text available
38030604
MYH9 affects USP27X
1 |
USP27X binds MYH9. 1 / 1
1 |
biogrid
No evidence text available
38030604
MYH10 affects USP27X
1 |
USP27X binds MYH10. 1 / 1
1 |
biogrid
No evidence text available
38030604
MTHFD1L affects USP27X
1 |
USP27X binds MTHFD1L. 1 / 1
1 |
biogrid
No evidence text available
38030604
MTDH affects USP27X
1 |
USP27X binds MTDH. 1 / 1
1 |
biogrid
No evidence text available
38030604
MRPS27 affects USP27X
1 |
USP27X binds MRPS27. 1 / 1
1 |
biogrid
No evidence text available
38030604
MRPS23 affects USP27X
1 |
USP27X binds MRPS23. 1 / 1
1 |
biogrid
No evidence text available
38030604
MIR603 affects USP27X
1 |
MIR603 decreases the amount of USP27X. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
MGA affects USP27X
1 |
USP27X binds MGA. 1 / 1
1 |
biogrid
No evidence text available
27132940
MCTS1 affects USP27X
1 |
USP27X binds MCTS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
MCM7 affects USP27X
1 |
USP27X binds MCM7. 1 / 1
1 |
biogrid
No evidence text available
38030604
MCM3 affects USP27X
1 |
USP27X binds MCM3. 1 / 1
1 |
biogrid
No evidence text available
38030604
MATR3 affects USP27X
1 |
USP27X binds MATR3. 1 / 1
1 |
biogrid
No evidence text available
27132940
MARK3 affects USP27X
1 |
USP27X binds MARK3. 1 / 1
1 |
biogrid
No evidence text available
38030604
MAGOH affects USP27X
1 |
USP27X binds MAGOH. 1 / 1
1 |
biogrid
No evidence text available
38030604
LUC7L3 affects USP27X
1 |
USP27X binds LUC7L3. 1 / 1
1 |
biogrid
No evidence text available
27132940
LUC7L2 affects USP27X
1 |
USP27X binds LUC7L2. 1 / 1
1 |
biogrid
No evidence text available
38030604
LSM14B affects USP27X
1 |
USP27X binds LSM14B. 1 / 1
1 |
biogrid
No evidence text available
38030604
LSM14A affects USP27X
1 |
USP27X binds LSM14A. 1 / 1
1 |
biogrid
No evidence text available
38030604
LSM12 affects USP27X
1 |
USP27X binds LSM12. 1 / 1
1 |
biogrid
No evidence text available
38030604
LMNB2 affects USP27X
1 |
USP27X binds LMNB2. 1 / 1
1 |
biogrid
No evidence text available
38030604
LAS1L affects USP27X
1 |
USP27X binds LAS1L. 1 / 1
1 |
biogrid
No evidence text available
38030604
KRI1 affects USP27X
1 |
USP27X binds KRI1. 1 / 1
1 |
biogrid
No evidence text available
38030604
KPNA1 affects USP27X
1 |
USP27X binds KPNA1. 1 / 1
1 |
biogrid
No evidence text available
38030604
KLHL12 affects USP27X
1 |
USP27X binds KLHL12. 1 / 1
1 |
biogrid
No evidence text available
38030604
KLF8 affects USP27X
1 |
KLF8 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
35140242
JUP affects USP27X
1 |
USP27X binds JUP. 1 / 1
1 |
biogrid
No evidence text available
38030604
IPO7 affects USP27X
1 |
USP27X binds IPO7. 1 / 1
1 |
biogrid
No evidence text available
38030604
IMP3 affects USP27X
1 |
USP27X binds IMP3. 1 / 1
1 |
biogrid
No evidence text available
38030604
ILF3 affects USP27X
1 |
USP27X binds ILF3. 1 / 1
1 |
biogrid
No evidence text available
38030604
ILF2 affects USP27X
1 |
USP27X binds ILF2. 1 / 1
1 |
biogrid
No evidence text available
38030604
IGKV1D-37 affects USP27X
1 |
USP27X binds IGKV1D-37. 1 / 1
1 |
biogrid
No evidence text available
38030604
IGKV1-6 affects USP27X
1 |
USP27X binds IGKV1-6. 1 / 1
1 |
biogrid
No evidence text available
38030604
IFIH1 affects USP27X
1 |
IFIH1 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
32027733
HYCC1 affects USP27X
| 1
HYCC1 activates USP27X. 1 / 1
| 1
reach
"All these results confirmed the HCC‐promoting ability of USP27X‐AS1.3.3 USP27X-AS1 promoted HCC progression in vivo."
38279869
HSPH1 affects USP27X
1 |
USP27X binds HSPH1. 1 / 1
1 |
biogrid
No evidence text available
38030604
HSPA9 affects USP27X
1 |
USP27X binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
27132940
HSPA8 affects USP27X
1 |
USP27X binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
27132940
HSPA5 affects USP27X
1 |
USP27X binds HSPA5. 1 / 1
1 |
biogrid
No evidence text available
38030604
HSPA1A affects USP27X
1 |
USP27X binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
27132940
HSP90AB1 affects USP27X
1 |
biogrid
No evidence text available
38030604
HNRNPL affects USP27X
1 |
USP27X binds HNRNPL. 1 / 1
1 |
biogrid
No evidence text available
38030604
HNRNPH2 affects USP27X
1 |
biogrid
No evidence text available
27132940
HNRNPF affects USP27X
1 |
USP27X binds HNRNPF. 1 / 1
1 |
biogrid
No evidence text available
27132940
HNRNPDL affects USP27X
1 |
USP27X binds HNRNPDL. 1 / 1
1 |
biogrid
No evidence text available
38030604
HELLS affects USP27X
1 |
USP27X binds HELLS. 1 / 1
1 |
biogrid
No evidence text available
38030604
HCFC1 affects USP27X
1 |
USP27X binds HCFC1. 1 / 1
1 |
biogrid
No evidence text available
38030604
H3C15 affects USP27X
1 |
USP27X binds H3C15. 1 / 1
1 |
biogrid
No evidence text available
38030604
H2BC3 affects USP27X
1 |
USP27X binds H2BC3. 1 / 1
1 |
biogrid
No evidence text available
27132940
H2AC8 affects USP27X
1 |
USP27X binds H2AC8. 1 / 1
1 |
biogrid
No evidence text available
27132940
H2AC1 affects USP27X
1 |
USP27X binds H2AC1. 1 / 1
1 |
biogrid
No evidence text available
38030604
Gentamicins affects USP27X
1 |
Gentamicins increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
33387578
GTPBP1 affects USP27X
1 |
USP27X binds GTPBP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
GTF3C5 affects USP27X
1 |
USP27X binds GTF3C5. 1 / 1
1 |
biogrid
No evidence text available
38030604
GTF3C1 affects USP27X
1 |
USP27X binds GTF3C1. 1 / 1
1 |
biogrid
No evidence text available
38030604
GRWD1 affects USP27X
1 |
USP27X binds GRWD1. 1 / 1
1 |
biogrid
No evidence text available
38030604
GPBP1 affects USP27X
1 |
USP27X binds GPBP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
GMPS affects USP27X
1 |
USP27X binds GMPS. 1 / 1
1 |
biogrid
No evidence text available
38030604
GEMIN4 affects USP27X
1 |
USP27X binds GEMIN4. 1 / 1
1 |
biogrid
No evidence text available
38030604
GARS1 affects USP27X
1 |
USP27X binds GARS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
GAR1 affects USP27X
1 |
USP27X binds GAR1. 1 / 1
1 |
biogrid
No evidence text available
38030604
GANAB affects USP27X
1 |
USP27X binds GANAB. 1 / 1
1 |
biogrid
No evidence text available
38030604
G3BP2 affects USP27X
1 |
USP27X binds G3BP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
FXR2 affects USP27X
1 |
USP27X binds FXR2. 1 / 1
1 |
biogrid
No evidence text available
38030604
FHL1 affects USP27X
1 |
USP27X binds FHL1. 1 / 1
1 |
biogrid
No evidence text available
38030604
FAU affects USP27X
1 |
USP27X binds FAU. 1 / 1
1 |
biogrid
No evidence text available
38030604
FASN affects USP27X
1 |
USP27X binds FASN. 1 / 1
1 |
biogrid
No evidence text available
38030604
FARS2 affects USP27X
1 |
USP27X binds FARS2. 1 / 1
1 |
biogrid
No evidence text available
38030604
FAM120C affects USP27X
1 |
USP27X binds FAM120C. 1 / 1
1 |
biogrid
No evidence text available
38030604
EWSR1 affects USP27X
1 |
USP27X binds EWSR1. 1 / 1
1 |
biogrid
No evidence text available
38030604
ETFA affects USP27X
1 |
USP27X binds ETFA. 1 / 1
1 |
biogrid
No evidence text available
38030604
ETF1 affects USP27X
1 |
USP27X binds ETF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
ENY2 affects USP51
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
EMG1 affects USP27X
1 |
USP27X binds EMG1. 1 / 1
1 |
biogrid
No evidence text available
38030604
ELOB affects USP27X
1 |
USP27X binds ELOB. 1 / 1
1 |
biogrid
No evidence text available
27132940
ELAVL2 affects USP27X
1 |
USP27X binds ELAVL2. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF6 affects USP27X
1 |
USP27X binds EIF6. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF5AL1 affects USP27X
1 |
biogrid
No evidence text available
38030604
EIF4B affects USP27X
1 |
USP27X binds EIF4B. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF4A3 affects USP27X
1 |
USP27X binds EIF4A3. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF4A2 affects USP27X
1 |
USP27X binds EIF4A2. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF4A1 affects USP27X
1 |
USP27X binds EIF4A1. 1 / 1
1 |
biogrid
No evidence text available
27132940
EIF3L affects USP27X
1 |
USP27X binds EIF3L. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF3G affects USP27X
1 |
USP27X binds EIF3G. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF3F affects USP27X
1 |
USP27X binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF3E affects USP27X
1 |
USP27X binds EIF3E. 1 / 1
1 |
biogrid
No evidence text available
38030604
EIF2AK2 affects USP27X
1 |
biogrid
No evidence text available
38030604
EGFR inhibitor affects USP27X
| 1
EGFR inhibitor activates USP27X. 1 / 1
| 1
reach
"In addition, in NSCLC cells, depletion of USP27x reduces apoptosis when treated with an EGFR inhibitor."
28279784
EEF1A1 affects USP27X
1 |
USP27X binds EEF1A1. 1 / 1
1 |
biogrid
No evidence text available
38030604
ECT2 affects USP27X
1 |
USP27X binds ECT2. 1 / 1
1 |
biogrid
No evidence text available
38030604
E3-ligase tripartite motif containing 28 affects USP27X
| 1
USP27X binds E3-ligase tripartite motif containing 28. 1 / 1
| 1
reach
"USP27X interacts with the E3-ligase tripartite motif containing 28 (TRIM28) and reduces the ubiquitination of E3-ligases TRIM28, but not ITCH and DTX1, which leads to decreased CFLAR protein [17]."
36551253
Dbi affects USP27X
| 1
Dbi increases the amount of USP27X. 1 / 1
| 1
sparser
"In addition, overexpression of Raptor and blockers of mitochondrial ROS blocked ODN-induced USP27x expression ( xref L and M)."
31901727
DTX1 affects USP27X
1 |
USP27X binds DTX1. 1 / 1
1 |
biogrid
No evidence text available
35044632
DNAJC8 affects USP27X
1 |
USP27X binds DNAJC8. 1 / 1
1 |
biogrid
No evidence text available
38030604
DNAJC13 affects USP27X
1 |
USP27X binds DNAJC13. 1 / 1
1 |
biogrid
No evidence text available
38030604
DIMT1 affects USP27X
1 |
USP27X binds DIMT1. 1 / 1
1 |
biogrid
No evidence text available
38030604
DHX30 affects USP27X
1 |
USP27X binds DHX30. 1 / 1
1 |
biogrid
No evidence text available
38030604
DENR affects USP27X
1 |
USP27X binds DENR. 1 / 1
1 |
biogrid
No evidence text available
38030604
DDX55 affects USP27X
1 |
USP27X binds DDX55. 1 / 1
1 |
biogrid
No evidence text available
38030604
DDX54 affects USP27X
1 |
USP27X binds DDX54. 1 / 1
1 |
biogrid
No evidence text available
38030604
DDX50 affects USP27X
1 |
USP27X binds DDX50. 1 / 1
1 |
biogrid
No evidence text available
27132940
DDX24 affects USP27X
1 |
USP27X binds DDX24. 1 / 1
1 |
biogrid
No evidence text available
38030604
DDX17 affects USP27X
1 |
USP27X binds DDX17. 1 / 1
1 |
biogrid
No evidence text available
27132940
DCAF7 affects USP27X
1 |
USP27X binds DCAF7. 1 / 1
1 |
biogrid
No evidence text available
38030604
DARS1 affects USP27X
1 |
USP27X binds DARS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
CSRP2 affects USP27X
1 |
USP27X binds CSRP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
CS affects USP27X
1 |
USP27X binds CS. 1 / 1
1 |
biogrid
No evidence text available
38030604
CPSF3 affects USP27X
1 |
USP27X binds CPSF3. 1 / 1
1 |
biogrid
No evidence text available
38030604
CPSF1 affects USP27X
1 |
USP27X binds CPSF1. 1 / 1
1 |
biogrid
No evidence text available
38030604
CORO1C affects USP27X
1 |
USP27X binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
38030604
CMTR1 affects USP27X
1 |
USP27X binds CMTR1. 1 / 1
1 |
biogrid
No evidence text available
38030604
CLIC1 affects USP27X
1 |
USP27X binds CLIC1. 1 / 1
1 |
biogrid
No evidence text available
38030604
CKB affects USP27X
1 |
USP27X binds CKB. 1 / 1
1 |
biogrid
No evidence text available
38030604
CDK1 affects USP27X
1 |
USP27X binds CDK1. 1 / 1
1 |
biogrid
No evidence text available
38030604
CCT4 affects USP27X
1 |
USP27X binds CCT4. 1 / 1
1 |
biogrid
No evidence text available
38030604
CCT2 affects USP27X
1 |
USP27X binds CCT2. 1 / 1
1 |
biogrid
No evidence text available
38030604
CCNB1 affects USP27X
1 |
USP27X binds CCNB1. 1 / 1
1 |
biogrid
No evidence text available
38030604
CBX3 affects USP27X
1 |
USP27X binds CBX3. 1 / 1
1 |
biogrid
No evidence text available
27132940
CBLN4 affects USP27X
1 |
USP27X binds CBLN4. 1 / 1
1 |
biogrid
No evidence text available
38030604
CAT affects USP27X
| 1
CAT increases the amount of USP27X. 1 / 1
| 1
reach
"However, ODN only increased USP27x expression within 3 h (Fig. 4D), and KD or KO of Cat K also induced USP27x expression (Fig. 4E and F)."
31901727
CAMK2D affects USP27X
1 |
USP27X binds CAMK2D. 1 / 1
1 |
biogrid
No evidence text available
38030604
C8orf33 affects USP27X
1 |
USP27X binds C8orf33. 1 / 1
1 |
biogrid
No evidence text available
38030604
C1orf35 affects USP27X
1 |
biogrid
No evidence text available
38030604
C1QBP affects USP27X
1 |
USP27X binds C1QBP. 1 / 1
1 |
biogrid
No evidence text available
27132940
BYSL affects USP27X
1 |
USP27X binds BYSL. 1 / 1
1 |
biogrid
No evidence text available
38030604
BOP1 affects USP27X
1 |
USP27X binds BOP1. 1 / 1
1 |
biogrid
No evidence text available
38030604
BMS1 affects USP27X
1 |
USP27X binds BMS1. 1 / 1
1 |
biogrid
No evidence text available
38030604
BLK affects USP27X
1 |
BLK binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
36736316
AuGCT affects USP27X
| 1
AuGCT activates USP27X. 1 / 1
| 1
reach
"AuGCT (AuGCT DNA‐SYN Biotechnology Co., Ltd) produced the full‐length human USP27X‐AS1 cDNA (2304 bp), which was then cloned into the expression vector pcDNA3.1(+) from Add‐gene."
38279869
Acrylamide affects USP27X
1 |
Acrylamide increases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
32763439
ATXN7L3 affects USP51
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
ATXN7L1 affects USP27X
1 |
ATXN7L1 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
33961781
ATXN7 affects USP27X
1 |
ATXN7 binds USP27X. 1 / 1
1 |
biogrid
No evidence text available
24981860
ATP5F1C affects USP27X
1 |
biogrid
No evidence text available
38030604
ATP5F1B affects USP27X
1 |
USP27X binds ATP5F1B. 1 / 1
1 |
biogrid
No evidence text available
38030604
ATAD3B affects USP27X
1 |
USP27X binds ATAD3B. 1 / 1
1 |
biogrid
No evidence text available
38030604
ATAD3A affects USP27X
1 |
USP27X binds ATAD3A. 1 / 1
1 |
biogrid
No evidence text available
38030604
ARHGEF12 affects USP27X
1 |
USP27X binds ARHGEF12. 1 / 1
1 |
biogrid
No evidence text available
38030604
API5 affects USP27X
1 |
USP27X binds API5. 1 / 1
1 |
biogrid
No evidence text available
38030604
ANXA5 affects USP27X
1 |
USP27X binds ANXA5. 1 / 1
1 |
biogrid
No evidence text available
38030604
ANXA2P2 affects USP27X
1 |
biogrid
No evidence text available
38030604
AMDHD2 affects USP27X
1 |
USP27X binds AMDHD2. 1 / 1
1 |
biogrid
No evidence text available
38030604
AIMP2 affects USP27X
1 |
USP27X binds AIMP2. 1 / 1
1 |
biogrid
No evidence text available
38030604
AIFM1 affects USP27X
1 |
USP27X binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
27132940
ADH5 affects USP27X
1 |
USP27X binds ADH5. 1 / 1
1 |
biogrid
No evidence text available
38030604
ACLY affects USP27X
1 |
USP27X binds ACLY. 1 / 1
1 |
biogrid
No evidence text available
38030604
ABCD3 affects USP27X
1 |
USP27X binds ABCD3. 1 / 1
1 |
biogrid
No evidence text available
38030604
5-formyluracil affects USP27X
| 1
5-formyluracil decreases the amount of USP27X. 1 / 1
| 1
reach
"Anti-cancer drug 5-FU regulates cell cycle progression and inhibits hepatocellular proliferation by downregulating USP27 expression."
29497124
5-fluorouracil affects USP27X
| 1
5-fluorouracil decreases the amount of USP27X. 1 / 1
| 1
reach
"Treatment with 5-fluorouracil (5-FU) decreases USP27x expression, and then induces degradation of cyclin E [56]."
31901727
3,4-methylenedioxymethamphetamine decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
20188158
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP27X. 1 / 1
1 |
ctd
No evidence text available
33387578