IndraLab
Statements
USP25 is modified
1
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90
USP25 is phosphorylated.
1
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53
USP25 is sumoylated.
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32
sparser
"Other reported examples include SUMOylation of the deubiquitinating enzyme USP25 which impairs binding to and hydrolysis of ubiquitin chains ( xref ), the E2 ubiquitin conjugation enzyme E2-25K, which prevents its interaction with the ubiquitin E1 enzyme ( xref ), and the E3 ubiquitin ligase RNF4 that target its substrates via SUMO/SIM interaction ( xref ; xref )."
USP25 is ubiquitinated.
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5
reach
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I and TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25."
reach
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I/TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25.In recent years, USP25 has been extensively studied and some novel functions have been revealed."
sparser
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I/TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25."
reach
"Overexpression of USP21 inhibited RNA virus induced RIG-I polyubiquitination and RIG-I-mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN-alpha and beta production, and antiviral responses in MEFs in response to RNA virus infection."
reach
"Ubiquitylation events are reversible processes, and, accordingly, several deubiquitylating enzymes, in particular ubiquitin specific peptidase 3 (USP3), USP21 and CYLD lysine 63 deubiquitinase (CYLD), modulate RIG-I signalling by removing K63-polyubiquitin chains, although with unique kinetics."
reach
"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."
reach
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I and TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25."
reach
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I/TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25.In recent years, USP25 has been extensively studied and some novel functions have been revealed."
sparser
"Using antibodies to various TRAF for immunoprecipitation revealed that USP25 interacted with TRAF5 and TRAF6, but not with TRAF3 in HBECs or MEFs after IL-17 stimulation, while TNF stimulation induced neither USP25-TRAF5, USP25-TRAF6 nor USP25-TRAF3 association ( xref and data not shown)."
sparser
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I/TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25."
USP25 affects cell population proliferation
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47
USP25 activates cell population proliferation.
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37
USP25 inhibits cell population proliferation.
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10
reach
"Deficiency in USP25 enhanced the extent of ubiquitination of TRAF3 and accelerated its degradation after TLR4 activation, which potentiated TLR4 induced activation of NF-kappaB (nuclear factor kappaB) and MAPK (mitogen activated protein kinase) signaling, but inhibited activation of the transcription factor IRF3 (interferon regulatory factor 3)."
reach
"Interestingly, we found that overexpression of USP21 WT but not C221A mutant inhibited IFN-beta, NF-kappaB, and ISRE reporter activities in HEK293T cells in response to transfected poly (I : C), which was known to be mediated by MDA5 (unpublished data), suggesting that USP21 might also target MDA5."
reach
"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
sparser
"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent
To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
reach
"In previous studies, we showed that Foxp3 could be ubiquitinated and degraded by the E3 ubiquitin ligase Stub1 (STIP1 homology and U-Box containing protein 1) or deubiquitinated and stabilized by the deubiquitinase USP21 (ubiquitin specific peptidase 21) (Chen et al., 2013; Yang et al., 2015; Li et al., 2016)."
USP25 affects Interferon
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1
27
USP25 inhibits Interferon.
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19
USP25 inhibits Interferon. 10 / 18
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18
reach
"To examine whether the inhibitory effects of USP25 on SEV induced type I IFN signaling is due to its deubiquitinase activity, wild-type USP25 (USP25-WT) and its mutants (C178A and H607A) lacking DUB activity were co-transfected with the promoter luciferase reporter plasmid of IFN-beta, IRF3, NF-kappaB and ISRE, and the luciferase activity was detected."
reach
"However, the catalytic mutants (C178A and H607A) devoid of DUB activity lost the ability of USP25 WT-mediated IFN inhibition to some degree, indicating that DUB activity is involved in USP25 inhibition of type I IFN induction.To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
USP25 bound to K63 and IFIH1 inhibits Interferon. 1 / 1
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1
USP25 activates Interferon.
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1
6
USP25 activates Interferon. 7 / 7
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1
6
reach
"Some of the reported mechanisms include regulation of suppressor of cytokine signaling 3-Phosphorylated signal transducer and activator of transcription 3, Wnt pathway/β-catenin, and NF-κB and c-Jun-N-terminal kinase (JNK) signaling pathways.27, 28, 30 29 A recent report showed that USP25 inhibited Toll-like receptor 4 (TLR4)-triggered proinflammatory signaling and promoted type I interferon signaling through deubiquitination of tumor necrosis factor receptor–associated factor (TRAF)3."
USP25 increases the amount of Interferon.
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1
USP25 increases the amount of Interferon. 1 / 1
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1
USP25 deubiquitinates Interferon.
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1
Modified USP25 leads to the deubiquitination of Interferon. 1 / 1
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1
reach
"Overexpression of USP21 inhibited RNA virus induced RIG-I polyubiquitination and RIG-I-mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN-alpha and beta production, and antiviral responses in MEFs in response to RNA virus infection."
sparser
"In addition, the ubiquitin-specific protease USP25 antagonizes Wnt signaling by promoting deubiquitination and stabilization of PARP5a/b, and disruption of PARP5a interaction with USP25 destabilizes PARP5a/b, leading to Axin1/2 stabilization and subsequent attenuation of Wnt signaling [ xref ]."
USP25 affects Neoplasm Invasiveness
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25
USP25 activates Neoplasm Invasiveness.
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17
USP25 activates Neoplasm Invasiveness. 10 / 17
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17
reach
"Afterward, the role of USP21 in cell migration and invasion was evaluated through Transwell assay, and the data in XREF_FIG showed that overexpression of USP21 accelerated the migration and invasion of AGS cells, whereas knockdown of USP21 pronouncedly reduced the migration and invasion of MKN-45 cells."
USP25 inhibits Neoplasm Invasiveness.
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8
reach
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I and TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25."
reach
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I/TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25.In recent years, USP25 has been extensively studied and some novel functions have been revealed."
sparser
"Using antibodies to various TRAF for immunoprecipitation revealed that USP25 interacted with TRAF5 and TRAF6, but not with TRAF3 in HBECs or MEFs after IL-17 stimulation, while TNF stimulation induced neither USP25-TRAF5, USP25-TRAF6 nor USP25-TRAF3 association ( xref and data not shown)."
sparser
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I/TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25."
reach
"Ensembles of the ubiquitin and USP21 complex were created (i) from a 100-ns molecular dynamic (MD) simulation by extracting structures every 40 ps and (ii) from structures whose atoms satisfy multiple atomic distance constraints, such as bond distances, after refining structures whose atoms were randomly initialized within an 8-nm 3 cube centered on the input positions as applied by the CONCOORD method."
reach
"Ub dist binds to the S1 site in MINDY1 with a buried surface area of only $750 Å 2 , a binding interface much smaller than those of other DUBs such as HAUSP/USP7 (1,700 Å 2 ), USP21 (1,700 Å 2 ), or USP2 (1,900 Å 2 ), which rely more on Ub dist binding for activity (Hu et al., 2002; Renatus et al., 2006; Ye et al., 2011) ."
reach
"Chen Y. et al identify that USP21 can deubiquitinate and stabilize EZH2 to promote cell proliferation and metastasis in bladder carcinoma (31); Zhang P. et al find that ZRANB1 is an EZH2 deubiquitinase and regulates EZH2 function in breast cancer through both catalytic activity-dependent and -independent manner (32)."
reach
"To determine whether USP21 can promote the deubiquitination of endogenous BRCA2 and/or the BRCA2 associated RAD51 and PALB2 proteins XREF_BIBR, XREF_BIBR, we measured the extent of (poly-) ubiquitin modifications on either protein in the presence or absence of USP21 overexpression."
sparser
"Biochemical dissection suggests that USP21 can associate with the C-terminal OB domains of BRCA2, and consistent with this, a tumor cell line with a C-terminal BRCA2 truncation is unresponsive to USP21 depletion with regard to BRCA2 stability and tumor growth (Figs. xref d and xref )."
reach
"USP4, for example, interacts directly with end resection factors CtIP and MRN [172], USP21 deubiquitinates and stabilizes BRCA2 to promote RAD51 binding and successful HR [173], and USP10 deubiquitinates and stabilizes p53 to promote its nuclear localization and apoptosis in response to DSBs [174]."
reach
"To determine whether USP21 can promote the deubiquitination of endogenous BRCA2 and/or the BRCA2 associated RAD51 and PALB2 proteins XREF_BIBR, XREF_BIBR, we measured the extent of (poly-) ubiquitin modifications on either protein in the presence or absence of USP21 overexpression."
sparser
"In addition, the ubiquitin-specific protease USP25 antagonizes Wnt signaling by promoting deubiquitination and stabilization of PARP5a/b, and disruption of PARP5a interaction with USP25 destabilizes PARP5a/b, leading to Axin1/2 stabilization and subsequent attenuation of Wnt signaling [ xref ]."
reach
"Collectively, these findings suggest that USP25 inhibits RIG-I/MDA5-dependent type I IFN signaling.To better understand the effects of USP25 in SEV-induced type I IFN signaling, we assessed whether expression of USP25 disrupts SEV-induced activation of IRF3 and NF-κB, the two important transcriptional factors in type I IFN signaling."
reach
"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
sparser
"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent
To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
reach
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I and TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25."
reach
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I/TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25.In recent years, USP25 has been extensively studied and some novel functions have been revealed."
sparser
"Further investigation will be required to identify USP25 mutants that disrupt the interaction of USP25 and RIG-I/TRAF6 but do not affect DUB activity; and to test whether these domains of USP25 interacting with RIG-I and TRAF6 also contribute to the inhibition of IFN induction by USP25."
reach
"According to our results, USP25 : a) interacted with and rescued the ERAD substrates CD3delta and APP, and counteracted HRD1 effects on CD3delta, b) localized in part at the ER and interacted with the ERAD components HRD1 and VCP and p97, c) reduced the levels of endogenous ubiquitinated species associated with HRD1 and VCP and p97, and d) regulated the levels of endogenous APP, as knockdown of endogenous USP25 was associated with lower levels of endogenous APP."
sparser
"According to our results, USP25: a) interacted with and rescued the ERAD substrates CD3δ and APP, and counteracted HRD1 effects on CD3δ, b) localized in part at the ER and interacted with the ERAD components HRD1 and VCP/p97, c) reduced the levels of endogenous ubiquitinated species associated with HRD1 and VCP/p97, and d) regulated the levels of endogenous APP, as knockdown of endogenous USP25 was associated with lower levels of endogenous APP."
reach
"Interestingly, we found that overexpression of USP21 WT but not C221A mutant inhibited IFN-beta, NF-kappaB, and ISRE reporter activities in HEK293T cells in response to transfected poly (I : C), which was known to be mediated by MDA5 (unpublished data), suggesting that USP21 might also target MDA5."
sparser
"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent
To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
sparser
"Whereas we cannot exclude that some aspects of exogenous Gli1-activation rely on primary cilium formation, taken together, our data showing (1) an interaction between USP21 and Gli1, (2) the regulation of PKA-dependent phosphorylation of Gli1 by USP21, and (3) the colocalisation of all three proteins at the centrosome in U2OS cells make a strong case for a regulatory role of USP21 that could be independent of cilium formation."
sparser
"Whereas we cannot exclude that some aspects of exogenous Gli1-activation rely on primary cilium formation, taken together, our data showing (1) an interaction between USP21 and Gli1, (2) the regulation of PKA-dependent phosphorylation of Gli1 by USP21, and (3) the colocalisation of all three proteins at the centrosome in U2OS cells make a strong case for a regulatory role of USP21 that could be independent of cilium formation."
reach
"Taken together, our results demonstrate that PCV2 infection activates the p38-MAPK signaling pathway mediated USP21 phosphorylation to inhibit the K63 ubiquitination of STING, which prevents the phosphorylation and transportation to the nucleus of IRF3, leading to an increase risk for PPV infection."
reach
"Ensembles of the ubiquitin and USP21 complex were created (i) from a 100-ns molecular dynamic (MD) simulation by extracting structures every 40 ps and (ii) from structures whose atoms satisfy multiple atomic distance constraints, such as bond distances, after refining structures whose atoms were randomly initialized within an 8-nm 3 cube centered on the input positions as applied by the CONCOORD method."
reach
"Ub dist binds to the S1 site in MINDY1 with a buried surface area of only $750 Å 2 , a binding interface much smaller than those of other DUBs such as HAUSP/USP7 (1,700 Å 2 ), USP21 (1,700 Å 2 ), or USP2 (1,900 Å 2 ), which rely more on Ub dist binding for activity (Hu et al., 2002; Renatus et al., 2006; Ye et al., 2011) ."
reach
"Hence, SNHG16 competitively bound to miR-4500 to regulate the expression of USP21.In the current study, we showed that oncogenic USP21 deubiquitinates and stabilizes YY1 and that YY1 transcriptionally activates lncRNA SNHG16, which further acts as a ceRNA to regulate USP21 (Fig. 8)."
reach
"However, the function of these networks and their mechanisms upstream and downstream in association with the pathogenesis of NSCLC remain poorly understood.Our current study, for the first time, reported that USP21 acted as an oncogene by deubiquitinating YY1 to stabilize its protein levels in NSCLC cells."
reach
"According to our results, USP25 : a) interacted with and rescued the ERAD substrates CD3delta and APP, and counteracted HRD1 effects on CD3delta, b) localized in part at the ER and interacted with the ERAD components HRD1 and VCP and p97, c) reduced the levels of endogenous ubiquitinated species associated with HRD1 and VCP and p97, and d) regulated the levels of endogenous APP, as knockdown of endogenous USP25 was associated with lower levels of endogenous APP."
sparser
"According to our results, USP25: a) interacted with and rescued the ERAD substrates CD3δ and APP, and counteracted HRD1 effects on CD3δ, b) localized in part at the ER and interacted with the ERAD components HRD1 and VCP/p97, c) reduced the levels of endogenous ubiquitinated species associated with HRD1 and VCP/p97, and d) regulated the levels of endogenous APP, as knockdown of endogenous USP25 was associated with lower levels of endogenous APP."
USP25 affects cell growth
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9
USP25 activates cell growth.
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7
USP25 inhibits cell growth.
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2
sparser
"To determine whether USP21 is a DUB of GSC, HEK 293T cells were co-transfected with Flag-GSC and HA-ubiquitin-K0 (HA-Ub-K0), with or without Myc-USP21 and Myc-WWP2; after 2 days, immunoprecipitation was performed using an anti-Flag antibody, and immunoblotting was performed with anti-HA and anti-Flag antibodies."
sparser
"In this study, we identified that 1 ) CSE reduced an unstable protein HDAC11 in BEAS-2B cells, 2 ) USP25 interacted with HDAC11 and deubiquitinated HDAC11 at sites K50 and K280, 3 ) CSE-mediated USP25 polyubiquitination and subsequent degradation, and 4 ) CSE impaired defensive abilities to P. aeruginosa invasion via USP25/HDAC11 signaling in BEAS-2B cells ( xref )."
sparser
"To determine whether USP21 is a DUB of GSC, HEK 293T cells were co-transfected with Flag-GSC and HA-ubiquitin-K0 (HA-Ub-K0), with or without Myc-USP21 and Myc-WWP2; after 2 days, immunoprecipitation was performed using an anti-Flag antibody, and immunoblotting was performed with anti-HA and anti-Flag antibodies."
reach
"To determine whether USP21 can promote the deubiquitination of endogenous BRCA2 and/or the BRCA2 associated RAD51 and PALB2 proteins XREF_BIBR, XREF_BIBR, we measured the extent of (poly-) ubiquitin modifications on either protein in the presence or absence of USP21 overexpression."
sparser
"Biochemical dissection suggests that USP21 can associate with the C-terminal OB domains of BRCA2, and consistent with this, a tumor cell line with a C-terminal BRCA2 truncation is unresponsive to USP21 depletion with regard to BRCA2 stability and tumor growth (Figs. xref d and xref )."
Valproic acid affects USP25
7
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Valproic acid increases the amount of USP25. 7 / 7
7
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USP25 affects activity
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7
USP25 affects activation
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6
sparser
"USP21 inhibits virus-induced IRF3 activation via binding to and deubiquitinating RIG-I. Genetic deletion of USP21 in primary MEFs, peritoneal macrophages (PMs), and BM–derived dendritic cells (BMDCs) enhances virus- and RIG-I CARD domain (RIG-I-CARD)–induced IRF3 activation, IFN-α/β production, and antiviral response."
sparser
"To further confirm that USP25 inhibited the LPS-induced activation of NF-κB and MAPKs, we performed electrophoretic mobility shift assays (EMSAs) with 32 P-labeled consensus NF-κB and AP-1 (c-Jun–c-Fos) probes and showed that a deficiency in USP25 potentiated LPS-induced, but not poly(I:C)-induced, activation of the transcription factors NF-κB and AP-1 ( xref )."
reach
"The input tagged proteins were verified with the indicated antibodies.doi: 10.1371/journal.pone.0080976.g002 USP25 Negatively Regulates Type I IFN Signaling PLOS ONE | www.plosone.orgdoi: 10.1371/journal.pone.0080976.g003 USP25 Negatively Regulates Type I IFN Signaling PLOS ONE | www.plosone.org manner."
reach
"However, the catalytic mutants (C178A and H607A) devoid of DUB activity lost the ability of USP25 WT-mediated IFN inhibition to some degree, indicating that DUB activity is involved in USP25 inhibition of type I IFN induction.To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
reach
"To examine whether the inhibitory effects of USP25 on SEV-induced type I IFN signaling is due to its deubiquitinase activity, wild-type USP25 (USP25-WT) and its mutants (C178A and H607A) lacking DUB activity were co-transfected with the promoter luciferase reporter plasmid of IFN-β, IRF3, NF-κB and ISRE, and the luciferase activity was detected."
USP25 affects Neoplasm Metastasis
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6
sparser
"Whereas we cannot exclude that some aspects of exogenous Gli1-activation rely on primary cilium formation, taken together, our data showing (1) an interaction between USP21 and Gli1, (2) the regulation of PKA-dependent phosphorylation of Gli1 by USP21, and (3) the colocalisation of all three proteins at the centrosome in U2OS cells make a strong case for a regulatory role of USP21 that could be independent of cilium formation."
CGAS affects USP25
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5
Barium(2+) affects USP25
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3
2
USP25 affects signaling
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5
sparser
"Overexpression of USP25 inhibited IL-17-triggered signaling, whereas USP25 deficiency resulted in more phosphorylation of the inhibitor IκBα and kinase Jnk and higher expression of chemokines and cytokines, as well as a prolonged half-life for chemokine CXCL1-encoding mRNA after treatment with IL-17."
USP25 affects inflammatory response
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5
USP25 inhibits inflammatory response.
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3
USP25 activates inflammatory response.
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2
USP25 activates inflammatory response. 2 / 2
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2
USP25 affects cGAS
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5
USP25 affects ISRE
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1
4
reach
"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
USP25 affects ISRE reporter
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5
reach
"Interestingly, we found that overexpression of USP21 WT but not C221A mutant inhibited IFN-beta, NF-kappaB, and ISRE reporter activities in HEK293T cells in response to transfected poly (I : C), which was known to be mediated by MDA5 (unpublished data), suggesting that USP21 might also target MDA5."
USP25 affects GC
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5
reach
"Further investigation showed that USP21 downregulates cyclin T1 mRNA levels by increasing methylation of histone K9 in the promoter of cyclin T1, a subunit of the positive transcription elongation factor b (P-TEFb) that interacts with Tat and transactivation response element (TAR) and is required for transcription stimulation and Tat stability."
reach
"Further investigation showed that USP21 downregulates cyclin T1 mRNA levels by increasing methylation of histone K9 in the promoter of cyclin T1, a subunit of the positive transcription elongation factor b (P-TEFb) that interacts with Tat and transactivation response element (TAR) and is required for transcription stimulation and Tat stability."
MiR-200c affects USP25
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4
USP25 affects cell differentiation
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4
USP25 affects Nasopharyngeal Carcinoma
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4
USP25 affects ISRE promoter
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4
USP25 inhibits ISRE promoter.
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3
USP25 activates ISRE promoter.
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1
sparser
"In this study, we identified that 1 ) CSE reduced an unstable protein HDAC11 in BEAS-2B cells, 2 ) USP25 interacted with HDAC11 and deubiquitinated HDAC11 at sites K50 and K280, 3 ) CSE-mediated USP25 polyubiquitination and subsequent degradation, and 4 ) CSE impaired defensive abilities to P. aeruginosa invasion via USP25/HDAC11 signaling in BEAS-2B cells ( xref )."
Trichostatin A affects USP25
3
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CGAS affects USP29
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3
Bisphenol A affects USP25
3
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Bisphenol A decreases the amount of USP25.
2
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Bisphenol A methylates USP25.
1
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USP29 affects cGAS
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3
USP25 affects ubH2A
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3
USP25 affects transcription, DNA-templated
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3
USP25 inhibits transcription, DNA-templated.
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2
USP25 activates transcription, DNA-templated.
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1
USP25 activates transcription, DNA-templated. 1 / 1
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1
USP25 affects synaptic function 5xFAD mice
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3
eidos
"To determine whether Usp25 deficiency restores synaptic function in 5xFAD mice , we measured hippocampal LTP and found that it was compromised in 5xFAD compared with WT and Usp25 + / - mice ; however , 5xFAD-associated LTP impairment was reversed in 5xFAD ; Usp25 + / - mice ( Fig. 3 , G and H ) ."
| PMC
USP25 affects polyubiquitination
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3
sparser
"Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I. Overexpression of USP21 inhibited RNA virus–induced RIG-I polyubiquitination and RIG-I–mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN-α/β production, and antiviral responses in MEFs in response to RNA virus infection."
sparser
"Taken together, our results demonstrate that PCV2 infection activates the p38-MAPK signaling pathway-mediated USP21 phosphorylation to inhibit the K63 ubiquitination of STING, which prevents the phosphorylation and transportation to the nucleus of IRF3, leading to an increase risk for PPV infection."
USP25 affects lipopolysaccharide
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3
USP25 activates lipopolysaccharide. 3 / 3
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3
reach
"To further confirm that USP25 inhibited the LPS induced activation of NF-kappaB and MAPKs, we performed electrophoretic mobility shift assays (EMSAs) with 32 P labeled consensus NF-kappaB and AP-1 (c-Jun-c-Fos) probes and showed that a deficiency in USP25 potentiated LPS induced, but not poly (I : C)-induced, activation of the transcription factors NF-kappaB and AP-1 (XREF_FIG)."
USP25 affects initiation
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3
USP25 affects homologous recombination
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3
USP25 affects cell migration
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3
USP25 activates cell migration.
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2
USP25 activates cell migration. 2 / 2
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2
USP25 inhibits cell migration.
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1
USP25 inhibits cell migration. 1 / 1
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1
USP25 affects cell death
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3
USP25 activates cell death. 3 / 3
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3
reach
"In this report, we found that PdPT is an inhibitor of multiple DUBs including USP7, USP10, USP14, USP15, USP25 and UCHL5, which contributes to the accumulation of ubiquitinated proteins and subsequent cell death in NSCLC cell lines.Regulated cell death requires activation of various regulators and effectors (23)."
sparser
"When we subjected membrane fractions from LPS-treated BMDMs to immunoprecipitation with an antibody against TLR4 (anti-TLR4 antibody), we observed that USP25, TRAF3, and TRAF6 were co-immunoprecipitated ( xref ), supporting the idea that LPS stimulates the formation of a membrane-bound TLR4 signaling complex consisting of USP25, TRAFs, and cIAPs."
sparser
"When we subjected membrane fractions from LPS-treated BMDMs to immunoprecipitation with an antibody against TLR4 (anti-TLR4 antibody), we observed that USP25, TRAF3, and TRAF6 were co-immunoprecipitated ( xref ), supporting the idea that LPS stimulates the formation of a membrane-bound TLR4 signaling complex consisting of USP25, TRAFs, and cIAPs."
reach
"Overexpression of USP25 inhibited IL-17-triggered signaling, whereas USP25 deficiency resulted in more phosphorylation of the inhibitor IkappaBalpha and kinase Jnk and higher expression of chemokines and cytokines, as well as a prolonged half-life for chemokine CXCL1 encoding mRNA after treatment with IL-17."
USP25 affects CD3delta
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3
reach
"According to our results, USP25 : a) interacted with and rescued the ERAD substrates CD3delta and APP, and counteracted HRD1 effects on CD3delta, b) localized in part at the ER and interacted with the ERAD components HRD1 and VCP and p97, c) reduced the levels of endogenous ubiquitinated species associated with HRD1 and VCP and p97, and d) regulated the levels of endogenous APP, as knockdown of endogenous USP25 was associated with lower levels of endogenous APP."
reach
"In addition, USP18-mediated deISGylation in vitro is approximately 40-fold faster than deISGylation by the cross-reactive deubiquitinating enzymes (DUB) USP21 [15] raising the question whether deISGylation by Ub/ISG15 cross-reactive DUBs is relevant in vivo.Despite enhanced ISGylation, mice homozygous for USP18-C61A (USP18 ) are healthy and display a normal lifespan [27]."
reach
"In addition, USP18-mediated deISGylation in vitro is approximately 40-fold faster than deISGylation by the cross-reactive deubiquitinating enzymes (DUB) USP21 [15] raising the question whether deISGylation by Ub/ISG15 cross-reactive DUBs is relevant in vivo.Despite enhanced ISGylation, mice homozygous for USP18-C61A (USP18C61A/C61A) are healthy and display a normal lifespan [27]."
reach
"Moreover, USP17 is a positive regulator of RORgammat in Th17 cells, whereas USP18 has been reported to modulate T cell activation and Th17 cell differentiation by deubiquitinating of the TAK1 and TAB1 complex [XREF_BIBR] and USP25 has been regarded as a negative regulator of IL-17-mediated inflammation via TRAF5 and TRAF6 deubiquitination [XREF_BIBR]."
sparser
"When we subjected membrane fractions from LPS-treated BMDMs to immunoprecipitation with an antibody against TLR4 (anti-TLR4 antibody), we observed that USP25, TRAF3, and TRAF6 were co-immunoprecipitated ( xref ), supporting the idea that LPS stimulates the formation of a membrane-bound TLR4 signaling complex consisting of USP25, TRAFs, and cIAPs."
CD3delta affects USP25
|
3
reach
"According to our results, USP25 : a) interacted with and rescued the ERAD substrates CD3delta and APP, and counteracted HRD1 effects on CD3delta, b) localized in part at the ER and interacted with the ERAD components HRD1 and VCP and p97, c) reduced the levels of endogenous ubiquitinated species associated with HRD1 and VCP and p97, and d) regulated the levels of endogenous APP, as knockdown of endogenous USP25 was associated with lower levels of endogenous APP."
Potassium chromate affects USP25
2
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Phenylmercury acetate affects USP25
2
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Pentachlorophenol affects USP25
2
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2
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Lipopolysaccharide, E coli O55-B5 phosphorylates USP25.
1
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Lipopolysaccharide, E coli O55-B5 increases the amount of USP25.
1
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Hsa_circ_0039053 affects USP25
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2
Hsa-miR-6867-5p affects USP25
2
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Hsa-miR-567 affects USP25
2
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Hsa-miR-511-3p affects USP25
2
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Hsa-miR-5011-5p affects USP25
2
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Hsa-miR-410-3p affects USP25
2
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Hsa-miR-297 affects USP25
2
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Hsa-miR-223-5p affects USP25
2
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Hsa-miR-200c-3p affects USP25
2
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Hsa-miR-190a-3p affects USP25
2
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Entinostat affects USP25
2
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Disulfiram affects USP25
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1
1
Disulfiram inhibits USP25. 2 / 2
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1
1
Cyclosporin A affects USP25
2
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Chloroquine affects USP25
2
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Chloroquine phosphorylates USP25.
1
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Chloroquine decreases the amount of USP25.
1
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All-trans-retinoic acid affects USP25
2
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Ubv.21.4CDelta2 affects USP25
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2
USP25 affects type I IFNs
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2
reach
"Consistent with these observations, LPS stimulated, K 48 -linked ubiquitination of TRAF3 was further potentiated, and the degradation of TRAF3 was accelerated in Usp25 -/- BMDMs compared to that in wild-type BMDMs, whereas reconstitution of USP25 deficient MEFs with TRAF3 inhibited the generation of proinflammatory cytokines and restored the generation of type I IFNs in response to LPS."
USP25 affects response
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2
USP25 affects reporter
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1
1
USP25 affects protein deubiquitination
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2
USP25 activates protein deubiquitination. 2 / 2
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2
eidos
"Recently , it has been shown that USP25 directly interacts with tankyrases through its C-terminal tail and promotes their deubiquitination and stabilization , thus regulating Wnt / beta-catenin signaling pathway , making an important impact in cell proliferation and human cancer development28 ."
USP25 affects microglia-mediated proinflammatory cytokine overproduction
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2
reach
"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
USP25 affects macropinocytosis
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2
USP25 affects innate immune response
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2
USP25 inhibits innate immune response.
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1
USP25 inhibits innate immune response. 1 / 1
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1
USP25 activates innate immune response.
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1
USP25 activates innate immune response. 1 / 1
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1
USP25 affects immune response
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2
USP25 affects growth factor
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2
USP25 activates growth factor. 2 / 2
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2
reach
"Our functional studies indicate a key role for USP21 in the governance of microtubule- and centrosome associated physiological processes : Depletion of USP21 in A549 cells compromises the reestablishment of a radial array of microtubules during recovery from cold induced depolymerization and also reduces the probability of primary cilium formation, whereas USP21 knockdown in PC12 cells inhibits nerve growth factor induced neurite outgrowth."
USP25 affects glycolytic process
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1
1
USP25 affects cell cycle
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2
USP25 affects activities
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2
sparser
"Furthermore, human USP21 inhibited SeV-induced IFN-β reporter activities in MEFs whereas mouse USP21 inhibited SeV-induced IFN-β reporter activities in HEK293T cells ( xref and not depicted), suggesting that USP21 function in antiviral signaling is not limited by cell type and is conserved between human and mouse."
USP25 affects Treg signature genes
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2
USP25 affects TBK1-NF-kappaB
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2
USP25 affects SNHG16
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2
sparser
"Fig. 16: Co-crystal DUB structures using diUb-ABPs. (A) USP21 bound to Met1 diUb ABP that contains a terminal aldehyde warhead (PDB: 2Y5B). (B) SARS PLpro in complex with a triazole linked K48 diUb ABP that contains a terminal propargyl warhead (PDB: 5E6J). (C) Cezanne/OTUD7B in complex with K11 diUb-ABP that contains an internal Michael acceptor warhead (PDB: 5LRV)."
| PMC
sparser
"Co-crystal DUB structures using diUb-ABPs. (A) USP21 bound to Met1 diUb ABP that contains a terminal aldehyde warhead (PDB: 2Y5B). (B) SARS PLpro in complex with a triazole linked K48 diUb ABP that contains a terminal propargyl warhead (PDB: 5E6J). (C) Cezanne/OTUD7B in complex with K11 diUb-ABP that contains an internal Michael acceptor warhead (PDB: 5LRV)"
| PMC
USP25 affects SERCA2a
|
2
reach
"Mechanistically, USP25 bound to SERCA2a directly via its USP (ubiquitin-specific protease) domain and cysteine at position 178 of USP25 exerts deubiquitination to maintain the stability of the SERCA2a protein by removing the K48 ubiquitin chain and preventing proteasomal pathway degradation, thereby maintaining calcium handling in cardiomyocytes."
USP25 affects NSCLC
|
2
reach
"No evidence was presented to support TRIM25 or USP21 mediated GLTSCR2 removal of K63-linked polyubiquitin chains from RIG-I.In this work, we presented evidence that viral infection induced translocation of GLTSCR2 from nucleus to cytoplasm, and cytoplasmic translocation enabled GLTSCR2 to effectively attenuate IFN-β and support viral replication; however, viral infection did not result in elevating GLTSCR2 in cells."
reach
"Overexpression of USP25 inhibited IL-17-triggered signaling, whereas USP25 deficiency resulted in more phosphorylation of the inhibitor IkappaBalpha and kinase Jnk and higher expression of chemokines and cytokines, as well as a prolonged half-life for chemokine CXCL1 encoding mRNA after treatment with IL-17."
USP25 affects IFN-I
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2
USP25 affects Hypertrophy
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2
USP25 affects Figure 6B
|
2
reach
"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
USP25 affects DNA Damage
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2
USP25 inhibits DNA Damage.
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1
USP25 inhibits DNA Damage. 1 / 1
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1
USP25 activates DNA Damage.
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1
USP25 activates DNA Damage. 1 / 1
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1
USP25 affects ChFP
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2
reach
"OTUB2, OTUD3, USP10 and UCHL1 expression did not alter the ChFP:GFP ratio of the control reporter while OTUD1 and USP21 only modestly elevated the ChFP:GFP ratio indicating that the identified Dubs specifically alter the ability of ribosomes to progress through a poly(A)-induced ribosomal stall (Figure 3B)."
USP25 affects BCR-ABL protein
|
2
USP25 affects Ala-Gly-Ser
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2
USP25 activates Ala-Gly-Ser. 2 / 2
|
2
reach
"Afterward, the role of USP21 in cell migration and invasion was evaluated through Transwell assay, and the data in XREF_FIG showed that overexpression of USP21 accelerated the migration and invasion of AGS cells, whereas knockdown of USP21 pronouncedly reduced the migration and invasion of MKN-45 cells."
USP25 affects AP AP-related organ injury
|
2
USP25 affects 5xFAD mice
|
2
SNHG16 affects USP25
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2
sparser
"Fig. 16: Co-crystal DUB structures using diUb-ABPs. (A) USP21 bound to Met1 diUb ABP that contains a terminal aldehyde warhead (PDB: 2Y5B). (B) SARS PLpro in complex with a triazole linked K48 diUb ABP that contains a terminal propargyl warhead (PDB: 5E6J). (C) Cezanne/OTUD7B in complex with K11 diUb-ABP that contains an internal Michael acceptor warhead (PDB: 5LRV)."
| PMC
sparser
"Co-crystal DUB structures using diUb-ABPs. (A) USP21 bound to Met1 diUb ABP that contains a terminal aldehyde warhead (PDB: 2Y5B). (B) SARS PLpro in complex with a triazole linked K48 diUb ABP that contains a terminal propargyl warhead (PDB: 5E6J). (C) Cezanne/OTUD7B in complex with K11 diUb-ABP that contains an internal Michael acceptor warhead (PDB: 5LRV)"
| PMC
SERCA2a affects USP25
|
2
reach
"Mechanistically, USP25 bound to SERCA2a directly via its USP (ubiquitin-specific protease) domain and cysteine at position 178 of USP25 exerts deubiquitination to maintain the stability of the SERCA2a protein by removing the K48 ubiquitin chain and preventing proteasomal pathway degradation, thereby maintaining calcium handling in cardiomyocytes."
|
2
EC 3.5.1.98 (histone deacetylase) inhibitor decreases the amount of USP25. 2 / 2
|
2
2
|
Vismodegib affects USP25
|
1
Vismodegib binds USP25. 1 / 1
|
1
Sodium arsenite affects USP25
1
|
Polyubiquitin affects USP25
|
1
Motif affects USP25
|
1
Monoubiquitin affects USP25
|
1
Mono(2-ethylhexyl) phthalate affects USP25
1
|
MiR-4500 affects USP25
|
1
MiR-27a-3p affects USP25
|
1
Methylmercury chloride affects USP25
1
|
Interaction affects USP25
|
1
Inserts domain molecule tetramer affects USP25
|
1
Hsa-miR-513a-5p affects USP25
1
|
Hsa-miR-411-5p affects USP25
1
|
Hsa-miR-27a-3p affects USP25
1
|
Hsa-miR-216a-3p affects USP25
1
|
Hsa-miR-144-3p affects USP25
1
|
Hsa-miR-128-3p affects USP25
1
|
Endoplasmic reticulum affects USP25
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1
Endoplasmic reticulum inhibits USP25. 1 / 1
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1
Dorsomorphin affects USP25
1
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Dicrotophos affects USP25
1
|
Cycloheximide affects USP25
|
1
Cycloheximide activates USP25. 1 / 1
|
1
reach
"To assess the effect of USP21 on FOXM1 half-life, FOXM1 levels were assessed by IB following overexpression of either USP21 WT or USP21 C221A in 293T cells (XREF_FIG) and depletion of USP21 in BLBC MDA-MB-231 cells (XREF_SUPPLEMENTARY) treated with cycloheximide to block protein translation."
Bis(2-chloroethyl) sulfide affects USP25
1
|
Amiodarone affects USP25
1
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Acrylamide affects USP25
1
|
sparser
"When we subjected membrane fractions from LPS-treated BMDMs to immunoprecipitation with an antibody against TLR4 (anti-TLR4 antibody), we observed that USP25, TRAF3, and TRAF6 were co-immunoprecipitated ( xref ), supporting the idea that LPS stimulates the formation of a membrane-bound TLR4 signaling complex consisting of USP25, TRAFs, and cIAPs."
Ubvs affects USP25
|
1
Ubv21.4 affects USP25
|
1
reach
"Furthermore, the median root mean square deviations of the MD, CONCOORD, and Backrub backbones were 0.63, 0.53, and 0.28 A, respectively, to the wild-type ubiquitin structure (PDB ID : 3I3T) and were 0.64, 0.57, and 0.37 A, respectively, to Ubv21.4, a known variant that tightly binds USP21 (PDB ID : 3MTN)."
Ubv affects USP25
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1
|
1
USP25 affects vismodegib
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1
Vismodegib binds USP25. 1 / 1
|
1
USP25 affects virus-induced IFN
|
1
USP25 affects type I interferons
|
1
USP25 affects translation
|
1
USP25-C221A inhibits translation. 1 / 1
|
1
reach
"To assess the effect of USP21 on FOXM1 half-life, FOXM1 levels were assessed by IB following overexpression of either USP21 WT or USP21 C221A in 293T cells (XREF_FIG) and depletion of USP21 in BLBC MDA-MB-231 cells (XREF_SUPPLEMENTARY) treated with cycloheximide to block protein translation."
USP25 affects transcription ISGs
|
1
USP25 affects stabilization
|
1
USP25 affects polyubiquitin
|
1
USP25 affects polyubiquitin chains
|
1
USP25 affects poly
|
1
USP25 affects pathology IL-17-dependent experimental autoimmune encephalomyelitis EAE
|
1
USP25 affects oe-USP21
|
1
USP25 affects monoubiquitin
|
1
USP25 affects miR-4500
|
1
USP25 affects isopeptidase
|
1
USP25 affects induced IFN-beta
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1
USP25 affects function
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1
|
1
USP25 inhibits epithelial to mesenchymal transition. 1 / 1
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1
USP25 affects energy homeostasis
|
1
USP25 activates energy homeostasis. 1 / 1
|
1
reach
"The outcomes of this research provide novel information as to how USP21 in skeletal muscle contributes to systemic energy homeostasis, demonstrating USP21 as a key molecule in the regulation of myofibre type switch, muscle mass control, mitochondrial function, and heat generation and, thus, implicating the potential of this molecule and its downstream substrates network as targets for the treatment and/or prevention of muscle dysfunction and the associated metabolic diseases."
USP25 affects degradation
|
1
USP25 affects beta cleavage APP Abeta
|
1
sparser
"When we subjected membrane fractions from LPS-treated BMDMs to immunoprecipitation with an antibody against TLR4 (anti-TLR4 antibody), we observed that USP25, TRAF3, and TRAF6 were co-immunoprecipitated ( xref ), supporting the idea that LPS stimulates the formation of a membrane-bound TLR4 signaling complex consisting of USP25, TRAFs, and cIAPs."
USP25 affects Ubv21.4
|
1
reach
"Furthermore, the median root mean square deviations of the MD, CONCOORD, and Backrub backbones were 0.63, 0.53, and 0.28 A, respectively, to the wild-type ubiquitin structure (PDB ID : 3I3T) and were 0.64, 0.57, and 0.37 A, respectively, to Ubv21.4, a known variant that tightly binds USP21 (PDB ID : 3MTN)."
USP25 affects Ubv.21.4CDelta2
|
1
USP25 affects Ubv
|
1
USP25 affects Trisomy 21-induced microglial homeostasis brains
|
1
USP25 affects TNKS-ARC5 protein
|
1
USP25 affects TLR4 signaling-induced innate immune responses
|
1
USP25 affects TGFβ-SMAD
|
1
USP25 affects TCF/LEF
|
1
USP25 affects RIG-I MDA5-dependent IFN signaling
|
1
USP25 affects Proteasome
|
1
USP25 activates Proteasome. 1 / 1
|
1
USP25 affects Pancreatitis
|
1
USP25 inhibits Pancreatitis. 1 / 1
|
1
USP25 affects PDAC cell death
|
1
USP25 affects NLR
|
1
USP25 affects MluI site
|
1
USP25 affects Lys48
|
1
USP25 affects K63-polyubiquitin chains
|
1
reach
"Ubiquitylation events are reversible processes, and, accordingly, several deubiquitylating enzymes, in particular ubiquitin specific peptidase 3 (USP3), USP21 and CYLD lysine 63 deubiquitinase (CYLD), modulate RIG-I signalling by removing K63-polyubiquitin chains, although with unique kinetics."
USP25 affects K63
|
1
USP25 affects K48
|
1
USP25 affects K27
|
1
USP25 affects IL-17-mediated inflammation
|
1
USP25 affects Hyperglycemia
|
1
USP25 activates Hyperglycemia. 1 / 1
|
1
reach
"USP22 in pancreatic β-cells, USP2 in adipose tissue macrophages, USP9X, 20, and 33 in myocytes, USP4, 7, 10, and 18 in hepatocytes, and USP2 in hypothalamus improve hyperglycemia, whereas USP19 in adipocytes, USP21 in myocytes, and USP2, 14, and 20 in hepatocytes promote hyperglycemia."
USP25 affects Hemagglutinin
|
1
USP25 binds Hemagglutinin. 1 / 1
|
1
reach
"Our results suggest that endogenous USP21 positively regulates Hh signaling through two independent mechanisms : firstly, we have previously shown that USP21 depletion interferes with the formation of primary cilia, the specialised organelles that host the initiation of the Hh signaling cascade in untransformed mammalian cells."
USP25 affects HA-ATP6V0C HA-WDFY1
|
1
USP25 affects H3K4me3
|
1
USP25 affects ERAD substrate CD3delta [
|
1
USP25 affects E3_Ub_ligase
|
1
USP25 affects Diabetes Mellitus, Type 2
|
1
USP25 inhibits Diabetes Mellitus, Type 2. 1 / 1
|
1
USP25 affects Cell Survival
|
1
USP25 inhibits Cell Survival. 1 / 1
|
1
USP25 affects CD3delta protein
|
1
USP25 affects Bacterial Infections
|
1
USP25 activates Bacterial Infections. 1 / 1
|
1
USP25 affects BCR-ABL
|
1
USP25 affects Abeta-induced phagocytosis synapses
|
1
UBL affects USP25
|
1
UBA1 affects monoubiquitin
|
1
sparser
"When we subjected membrane fractions from LPS-treated BMDMs to immunoprecipitation with an antibody against TLR4 (anti-TLR4 antibody), we observed that USP25, TRAF3, and TRAF6 were co-immunoprecipitated ( xref ), supporting the idea that LPS stimulates the formation of a membrane-bound TLR4 signaling complex consisting of USP25, TRAFs, and cIAPs."
TRAF3 affects K48
|
1
TNKS-ARC5 protein affects USP25
|
1
sparser
"When we subjected membrane fractions from LPS-treated BMDMs to immunoprecipitation with an antibody against TLR4 (anti-TLR4 antibody), we observed that USP25, TRAF3, and TRAF6 were co-immunoprecipitated ( xref ), supporting the idea that LPS stimulates the formation of a membrane-bound TLR4 signaling complex consisting of USP25, TRAFs, and cIAPs."
STING1 affects K27
|
1
1
|
PTM [ affects USP25
|
1
NLR affects USP25
|
1
MluI site affects USP25
|
1
MAP2K2 affects Lys48
|
1
MACE affects USP25
|
1
Lys48 affects USP25
|
1
KCTD6 affects E3_Ub_ligase
|
1
K63 affects USP25
|
1
K48 affects USP25
|
1
K27 affects USP25
|
1
Hemagglutinin affects USP25
|
1
USP25 binds Hemagglutinin. 1 / 1
|
1
E3_Ub_ligase affects USP25
|
1
Dnmt1 affects monoubiquitin
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1
CUL3 affects E3_Ub_ligase, KCTD6, and USP25
|
1
Aroclor 1254 affects USP25
1
|
Antirheumatic Agents affects USP25
1
|
7,12-dimethyltetraphene affects USP25
1
|