IndraLab

Statements

USP19 affects CORO2A
1 | 11 6
USP19 binds CORO2A.
| 5 6
USP19 binds CORO2A. 9 / 9
| 5 4
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"Co-immunoprecipitation assay revealed that USP19 strongly binds with CORO2A."
27129179
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"These results show that the binding of CORO2A and USP19 was not dependent on both normal and cancer cells."
27129179
sparser
"Together, our results demonstrate the importance of the interaction between USP19 and CORO2A in the regulation of RAR, which is possibly involved in adipogenesis."
27129179
reach
"Together, our results demonstrate the importance of the interaction between USP19 and CORO2A in the regulation of RAR, which is possibly involved in adipogenesis."
27129179
sparser
"Co-immunoprecipitation assay revealed that USP19 strongly binds with CORO2A (Figure xref and xref )."
27129179
sparser
"These results show that the binding of CORO2A and USP19 was not dependent on both normal and cancer cells."
27129179
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"We next validated the association between USP19 and CORO2A, and the regulation of CORO2A by USP19."
27129179
sparser
"USP19 is associated with the ubiquitination of CORO2A."
27129179
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"We next evaluated the endogenous binding between CORO2A and USP19."
27129179
RAR binds USP19 and CORO2A. 2 / 2
| 2
sparser
"The results suggest that USP19 may be associated with the transcriptional regulation of RAR via CORO2A as one of the components for the NCoR complex during the adipogenesis."
27129179
sparser
"These results indicate that USP19 is associated with the regulation of transcriptional repression of RAR through CORO2A."
27129179
USP19 activates CORO2A.
| 3
USP19 activates CORO2A. 3 / 5
| 3
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"These results indicate that USP19 may prevent proteasomal degradation of CORO2A."
27129179
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"Overexpression of USP19 inhibited RARE transcription and knock-down of USP19 using siRNA showed dramatically increased transcription of RARE, suggesting that USP19 increases the stability of CORO2A by DUB activity, and that binding of these two protein may be associated with the function of NCoR."
27129179
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"The result showed that CORO2A was gradually increased by USP19 expression."
27129179
USP19 deubiquitinates CORO2A.
1 | 1
USP19 deubiquitinates CORO2A. 2 / 2
1 | 1
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"And USP19 deubiquitinated CORO2A, suggesting that USP19 might have function to stabilize NCoR co and repressor complex in cells."
27129179
ubibrowser
"Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A"
27129179
USP19 decreases the amount of CORO2A.
| 2
USP19 decreases the amount of CORO2A. 1 / 1
| 1
reach
"Since USP19 reduced the ubiquitination level of CORO2A, we next tested the expression level of CORO2A upon USP19 dose dependent expression."
27129179
USP19-C506S decreases the amount of CORO2A. 1 / 1
| 1
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"However, the catalytic mutant USP19 (C506S) did not significantly decrease the ubiquitination level of CORO2A."
27129179
USP19 affects SYVN1
1 1 | 9 3
USP19 binds SYVN1.
1 | 2 3
USP19 binds SYVN1. 6 / 8
1 | 2 3
reach
"We reported that USP19 interacts with and targets HRD1 for the deubiquitination of K48 linked ubiquitin chains, the primary signal for proteasomal degradation [XREF_BIBR, XREF_BIBR] (XREF_FIG A and XREF_FIG A)."
27827840
sparser
"These results suggest that USP19 interacts with HRD1."
27827840
biogrid
No evidence text available
24356957
sparser
"However, there was no association between Myc-USP19 and FLAG-Nixin detected ( xref B), supporting the specificity of the USP19 interaction with HRD1."
27827840
reach
"These results suggest that USP19 interacts with HRD1."
27827840
sparser
"USP19 Interacts with HRD1."
27827840
USP19 deubiquitinates SYVN1.
1 | 3
USP19 deubiquitinates SYVN1. 4 / 4
1 | 3
ubibrowser
"We demonstrate that USP19 rescues HRD1 from proteasomal degradation by deubiquitination of K48-linked ubiquitin chains."
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"USP19 negatively regulates the ubiquitination of HRD1 and prevents it from undergoing proteasomal degradation."
27827840
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"These results suggest that USP19 deubiquitinates HRD1."
27827840
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"USP19 Deubiquitinates HRD1."
27827840
USP19 activates SYVN1.
| 2
USP19 activates SYVN1. 2 / 4
| 2
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"We demonstrate that USP19 rescues HRD1 from proteasomal degradation by deubiquitination of K48 linked ubiquitin chains."
27827840
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"In this study, we found that overexpression of USP19 also increases the stability and steady-state expression levels of HRD1 in a manner dependent on its DUB activity (XREF_FIG A, XREF_FIG A and Figure S7)."
27827840
USP19 inhibits SYVN1.
| 1
USP19 inhibits SYVN1. 1 / 1
| 1
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"This raises the possibility that USP19 might negatively regulate HRD1 mediated protein dislocation, thereby leading to increased expression of HRD1 itself."
27827840
USP19 increases the amount of SYVN1.
| 1
USP19 increases the amount of SYVN1. 1 / 1
| 1
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"Therefore, these results suggest that USP19 positively regulates the HRD1 level by protecting it from ERAD through a DUB activity dependent mechanism."
27827840
USP19 affects cell differentiation
| 13 4
USP19 inhibits cell differentiation.
| 10 4
USP19 inhibits cell differentiation. 10 / 14
| 10 4
sparser
"USP19-ER inhibited both muscle cell differentiation and the unfolded protein response gene CHOP that occurs during differentiation."
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"Consistent with these findings, a deubiquitinase USP19 suppressed pTh17 differentiation in vitro as well as Th17-mediated pathogenesis in murine autoimmune models."
34135062
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"Consistent with these findings, the deubiquitinase USP19 suppressed pTh17 differentiation in vitro as well as Th17-mediated pathogenesis in vivo."
34135062
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"Consistent with this finding, the deubiquitinase USP19 was shown to suppress pTh17 differentiation in vitro and Th17-mediated pathogenesis in vivo."
34135062
sparser
"USP19 can inhibit myogenic differentiation through suppression of an unfolded protein response that is required for muscle cell fusion xref ."
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"These results suggested that USP19 inhibits muscle cell differentiation by suppressing the differentiation dependent induction of the UPR during myogenesis."
25568336
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"USP19 can inhibit myogenic differentiation through suppression of an unfolded protein response that is required for muscle cell fusion 74."
26918171
sparser
"These results suggested that USP19 inhibits muscle cell differentiation by suppressing the differentiation-dependent induction of the UPR during myogenesis."
25568336
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"Because USP19 inhibits differentiation, it was somewhat surprising to observe its induction during differentiation."
25568336
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"In the case of USP19, we have also provided evidence that this modulation of UPR signaling may also occur in vivo during myogenic regeneration in response to muscle injury and that loss of USP19 can lead to a more rapid differentiation and larger myofibers (XREF_FIG)."
25568336
USP19 activates cell differentiation.
| 3
USP19 activates cell differentiation. 3 / 3
| 3
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"Our previous observations that silencing USP19 induced expression of myofibrillar proteins as well as myogenin in muscle cells suggested that USP19 might modulate muscle cell differentiation."
25568336
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"These results suggested that USP19 inhibits muscle cell differentiation by suppressing the differentiation dependent induction of the UPR during myogenesis."
25568336
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"We therefore tested whether USP19 modulates this differentiation dependent CHOP induction and, if so, whether it requires ER localization."
25568336
USP19 affects MARCHF6
1 | 12 2
USP19 binds MARCHF6.
| 3 2
USP19 binds MARCHF6. 5 / 6
| 3 2
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"Here, we show that USP19 interacts with the ERAD associated E3 ubiquitin ligase MARCH6."
25088257
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"Since transmembrane USP19 and MARCH6 have been shown to be localized to the ER, we first assessed the possibility that USP19 interacts with MARCH6."
25088257
sparser
"Since transmembrane USP19 and MARCH6 have been shown to be localized to the ER, we first assessed the possibility that USP19 interacts with MARCH6."
25088257
sparser
"Here, we show that USP19 interacts with the ERAD-associated E3 ubiquitin ligase MARCH6."
25088257
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"We found that USP19 also interacts with and stabilizes MARCH6."
25088257
USP19 deubiquitinates MARCHF6.
1 | 3
USP19 deubiquitinates MARCHF6. 2 / 2
1 | 1
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"In this study, we show that USP19 deubiquitinates and stabilizes MARCH6."
25088257
ubibrowser
"USP19 was found to protect MARCH6 by deubiquitination from the p97-dependent proteasomal degradation."
25088257
Modified USP19 leads to the deubiquitination of MARCHF6. 2 / 2
| 2
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"We also show that USP19 overexpression reduced ubiquitination of MARCH6, while its knockdown had the opposite effect."
25088257
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"USP19 overexpression reduces the K48 linked ubiquitination of MARCH6."
25088257
USP19 increases the amount of MARCHF6.
| 3
USP19 increases the amount of MARCHF6. 3 / 3
| 3
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"In support of this hypothesis, we showed that ABCB11 G238V was stabilized by the USP19 knockdown that reduced MARCH6 expression."
25088257
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"Since enzyme activity is generally proportional to the protein expression levels, we expected that knockdown of USP19 would reduce MARCH6 expression, which in turn would stabilize the ABCB11 G238V mut[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25088257
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"Furthermore, we addressed whether knockdown of the endogenous USP19 protein with small interfering RNA (siRNA) would reduce the levels of endogenous MARCH6."
25088257
USP19 activates MARCHF6.
| 2
USP19 activates MARCHF6. 2 / 2
| 2
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"These results suggest that USP19 is likely to positively regulate the MARCH6 mediated ERAD of ABCB11 G238V."
25088257
reach
"Further investigation is needed to elucidate the physiological significance of USP19 mediated stabilization of MARCH6, and also to identify novel substrates and regulatory factors."
25088257
USP19 ubiquitinates MARCHF6.
| 1
USP19 ubiquitinates MARCHF6. 1 / 1
| 1
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"Reduced USP19 expression resulted in an increase in ubiquitination of FLAG-MARCH6."
25088257
USP19 affects HDAC1
2 1 | 4 3
USP19 binds HDAC1.
2 | 4 3
USP19 binds HDAC1. 7 / 10
2 | 4 1
biogrid
No evidence text available
27517492
reach
"Interestingly, as shown in Figure XREF_FIG and Figure XREF_FIG, we found much stronger binding of USP19 to HDAC1 in response to IR irradiation, further suggesting the HDAC and USP19 complex was involved in DNA damage response."
27517492
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"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19."
27517492
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"Of all the binding proteins, we found USP19 could interact with HDAC1 and HDAC2, which have been reported to play important roles in DNA damage repair."
27517492
sparser
"Interestingly, as shown in Figure xref and Figure xref , we found much stronger binding of USP19 to HDAC1 in response to IR irradiation, further suggesting the HDAC-USP19 complex was involved in DNA damage response."
27517492
biogrid
No evidence text available
27517492
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"USP19 interacts with HDAC1 and HDAC2."
27517492
USP19 binds HDAC1 and HDAC2. 2 / 2
| 2
sparser
"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19 (Figure xref and xref )."
27517492
sparser
"USP19 interacts with HDAC1 and HDAC2."
27517492
USP19 deubiquitinates HDAC1.
1 |
USP19 deubiquitinates HDAC1. 1 / 1
1 |
ubibrowser
"USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability"
27517492
USP19 activates cell population proliferation. 5 / 7
| 5
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"These results indicated that USP19 enhanced cell proliferation and exhibited anti-apoptotic properties."
32904569
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"USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1."
19015242
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"We previously reported that the USP19 deubiquitinating enzyme positively regulates proliferation in fibroblasts by stabilizing KPC1, a ubiquitin ligase for p27 Kip1."
21264218
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"The results showed that knockdown of USP19 suppressed cell proliferation in SGC7901 cells while overexpressing USP19 accelerated cell growth in GES1 cells, as determined by MTT assay (P < 0.01, XREF_FIG and XREF_FIG)."
32904569
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"Reports indicate that the disruption of USP19 inhibits a series of PCa cell proliferation by arresting cells in the G1 to S phase transition through stabilization of the cyclin-dependent kinase inhibitor p27 ."
34660907
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"USP19 deubiquitinates and thereby stabilizes the KPC1 ligase for p27 Kip1, and so indirectly promotes degradation of p27 Kip1 and subsequent cell proliferation."
21264218
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"Opposite to our findings, Hu and collaborators recently demonstrated that USP19 negatively regulates proliferation and migration in clear cell renal carcinoma 69."
33714979
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"USP19 overexpression inhibited ccRCC proliferation and migration, whereas USP19 knockdown promoted ccRCC proliferation and migration invitro."
32236633
sparser
"Depletion of USP19 inhibited proliferation in prostate cancer DU145, PC-3 and 22RV1 cells, which was similar to the pattern established in fibroblasts in that it was due to decreased progression from G1 to S phase and associated with a stabilization of the cyclin-dependent kinase inhibitor p27 Kip1 ."
21264218
reach
"Depletion of USP19 inhibited proliferation in prostate cancer DU145, PC-3 and 22RV1 cells, which was similar to the pattern established in fibroblasts in that it was due to decreased progression from G1 to S phase and associated with a stabilization of the cyclin dependent kinase inhibitor p27 Kip1."
21264218
HDAC1 affects USP19
2 | 4 3
USP19 binds HDAC1. 7 / 10
2 | 4 1
biogrid
No evidence text available
27517492
reach
"Interestingly, as shown in Figure XREF_FIG and Figure XREF_FIG, we found much stronger binding of USP19 to HDAC1 in response to IR irradiation, further suggesting the HDAC and USP19 complex was involved in DNA damage response."
27517492
reach
"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19."
27517492
reach
"Of all the binding proteins, we found USP19 could interact with HDAC1 and HDAC2, which have been reported to play important roles in DNA damage repair."
27517492
sparser
"Interestingly, as shown in Figure xref and Figure xref , we found much stronger binding of USP19 to HDAC1 in response to IR irradiation, further suggesting the HDAC-USP19 complex was involved in DNA damage response."
27517492
biogrid
No evidence text available
27517492
reach
"USP19 interacts with HDAC1 and HDAC2."
27517492
USP19 binds HDAC1 and HDAC2. 2 / 2
| 2
sparser
"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19 (Figure xref and xref )."
27517492
sparser
"USP19 interacts with HDAC1 and HDAC2."
27517492
SIAH2 affects USP19
4 | 5 2
SIAH2 binds USP19.
4 | 2 1
SIAH2 binds USP19. 7 / 7
4 | 2 1
sparser
"SIAH2 binds to USP19 and promotes USP19 ubiquitylation and proteasome‐dependent degradation xref ; then, the hypothesis of a causal link between SIAH2 and USP19 in cardiomyocyte hypertrophy was established: Decreased transcription of SIAH2 during hypertrophic progress led to less degradation of USP19, and this mechanism partially accounted for USP19 elevation."
32798288
biogrid
No evidence text available
22128162
reach
"Probing Western blots of anti-Myc immunoprecipitates with an anti-HA antibody confirmed that USP19 interacts with both SIAH1 and SIAH2."
23500468
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"To assess whether USP19 interacts with SIAH1 and SIAH2 in eukaryotic cells, HEK293T cells were co-transfected with plasmids expressing Myc-USP19 and HA-SIAH1 or HA-SIAH2 and cell lysates were subjecte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23500468
biogrid
No evidence text available
22128162
biogrid
No evidence text available
23500468
biogrid
No evidence text available
23500468
SIAH2 ubiquitinates USP19.
| 1 1
SIAH2 leads to the ubiquitination of USP19. 2 / 2
| 1 1
reach
"Here we report that USP19 interacts with the ubiquitin ligases SIAH1 and SIAH2, which promote USP19 ubiquitylation and degradation by the proteasome."
23500468
sparser
"SIAH2 binds to USP19 and promotes USP19 ubiquitylation and proteasome‐dependent degradation xref ; then, the hypothesis of a causal link between SIAH2 and USP19 in cardiomyocyte hypertrophy was established: Decreased transcription of SIAH2 during hypertrophic progress led to less degradation of USP19, and this mechanism partially accounted for USP19 elevation."
32798288
SIAH2 inhibits USP19.
| 1
SIAH2 inhibits USP19. 1 / 1
| 1
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"The expression levels of Myc-USP19 Delta462-473 remained constant in spite of SIAH overexpression while Myc-USP19 was efficiently degraded, confirming that the SIAH binding motif is required for USP19[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23500468
SIAH2 decreases the amount of USP19.
| 1
Modified SIAH2 decreases the amount of USP19. 1 / 1
| 1
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"Co-expression of functional SIAH1 or SIAH2 dramatically decreased the expression levels of Myc-USP19, while the expression was rescued by in treatment with MG132, suggesting that both SIAHs target USP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23500468
SIAH1 affects USP19
6 | 5
SIAH1 binds USP19.
6 | 2
SIAH1 binds USP19. 8 / 8
6 | 2
biogrid
No evidence text available
22128162
biogrid
No evidence text available
27776223
biogrid
No evidence text available
23500468
reach
"To assess whether USP19 interacts with SIAH1 and SIAH2 in eukaryotic cells, HEK293T cells were co-transfected with plasmids expressing Myc-USP19 and HA-SIAH1 or HA-SIAH2 and cell lysates were subjecte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23500468
biogrid
No evidence text available
27776223
biogrid
No evidence text available
27776223
reach
"Probing Western blots of anti-Myc immunoprecipitates with an anti-HA antibody confirmed that USP19 interacts with both SIAH1 and SIAH2."
23500468
biogrid
No evidence text available
23500468
SIAH1 ubiquitinates USP19.
| 1
SIAH1 leads to the ubiquitination of USP19. 1 / 1
| 1
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"Here we report that USP19 interacts with the ubiquitin ligases SIAH1 and SIAH2, which promote USP19 ubiquitylation and degradation by the proteasome."
23500468
SIAH1 inhibits USP19.
| 1
SIAH1 inhibits USP19. 1 / 1
| 1
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"The expression levels of Myc-USP19 Delta462-473 remained constant in spite of SIAH overexpression while Myc-USP19 was efficiently degraded, confirming that the SIAH binding motif is required for USP19[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23500468
SIAH1 decreases the amount of USP19.
| 1
Modified SIAH1 decreases the amount of USP19. 1 / 1
| 1
reach
"Co-expression of functional SIAH1 or SIAH2 dramatically decreased the expression levels of Myc-USP19, while the expression was rescued by in treatment with MG132, suggesting that both SIAHs target USP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23500468
CORO2A affects USP19
| 5 6
USP19 binds CORO2A. 9 / 9
| 5 4
reach
"Co-immunoprecipitation assay revealed that USP19 strongly binds with CORO2A."
27129179
reach
"These results show that the binding of CORO2A and USP19 was not dependent on both normal and cancer cells."
27129179
sparser
"Together, our results demonstrate the importance of the interaction between USP19 and CORO2A in the regulation of RAR, which is possibly involved in adipogenesis."
27129179
reach
"Together, our results demonstrate the importance of the interaction between USP19 and CORO2A in the regulation of RAR, which is possibly involved in adipogenesis."
27129179
sparser
"Co-immunoprecipitation assay revealed that USP19 strongly binds with CORO2A (Figure xref and xref )."
27129179
sparser
"These results show that the binding of CORO2A and USP19 was not dependent on both normal and cancer cells."
27129179
reach
"We next validated the association between USP19 and CORO2A, and the regulation of CORO2A by USP19."
27129179
sparser
"USP19 is associated with the ubiquitination of CORO2A."
27129179
reach
"We next evaluated the endogenous binding between CORO2A and USP19."
27129179
RAR binds USP19 and CORO2A. 2 / 2
| 2
sparser
"The results suggest that USP19 may be associated with the transcriptional regulation of RAR via CORO2A as one of the components for the NCoR complex during the adipogenesis."
27129179
sparser
"These results indicate that USP19 is associated with the regulation of transcriptional repression of RAR through CORO2A."
27129179
USP19 affects EWSR1
| 1 9
USP19 binds EWSR1.
| 9
USP19 binds EWSR1 and FLI1. 5 / 5
| 5
sparser
"It is therefore likely that EWS-FLI1 interacts with USP19 in the cytosol as the fusion protein displays a constant turnover and is shuffling in and out of the nucleus xref ."
30700749
sparser
"For this, we co-expressed myc-USP19 with 3xflag-EWS-FLI1 wild-type or mutants (K298R or K380R) and observed binding of USP19 to both EWS-FLI1 mutants, indicating that the interaction itself is independent of the presence of an ubiquitin chain (Fig.  xref )."
30700749
sparser
"Most interestingly, co-expression of active USP19 with EWS-FLI1 stabilized the fusion protein whereas full length EWSR1 and FLI1 protein levels remained unchanged even though binding of USP19 to both EWS-FLI1 and full length EWSR1 was observed in immunoprecipitation experiments."
30700749
sparser
"USP19 interacts with the N-terminal domain of EWS-FLI1 and full length EWSR1."
30700749
sparser
"More recently, USP19 was shown to deubiquitinate and stabilise EWS-FLI-1 fusions but not FLI-1, likely because USP19 bound to EWS-FLI-1 within N-terminal EWS sequences [ xref ]."
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USP19 binds EWSR1. 2 / 2
| 2
sparser
"Importantly, stabilization appears to be specific for the fusion protein as it could not be observed neither for EWSR1 nor for FLI1 wild type proteins even though USP19 binds to the N-terminal EWS region to regulate deubiquitination of both EWS-FLI1 and EWSR1."
30700749
sparser
"USP19 binds to the EWSR1 domain of the fusion protein, as demonstrated by co-immunoprecipitation experiments, and reduces ubiquitination at an acceptor lysine site (the K380 residue xref ) in the FLI1 domain."
30700749
USP19 binds EWSR1, EWSR1, and FLI1. 1 / 1
| 1
sparser
"Strikingly, when USP19 was co-expressed with the full length proteins EWSR1 and FLI1, only full length EWSR1 but not wild type FLI1 could be immunoprecipitated indicating that USP19 binds to the N-terminal domain of EWSR1 and EWS-FLI1 (Fig.  xref )."
30700749
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
USP19 activates EWSR1.
| 1
USP19 activates EWSR1. 1 / 1
| 1
eidos
"Even though USP19 specifically modulated EWS-FLI1 but not EWSR1 protein levels ( Fig. 2e ) , we were still interested if USP19 possibly alters EWSR1 monoubiquitination levels35 ."
30700749
USP19 activates Neoplasm Invasiveness. 9 / 9
| 1 8
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"Collectively, our results indicate that USP19 knockdown inhibits tumor cell invasion in vitro."
33714979
eidos
"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life ."
33714979
reach
"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer."
33714979
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"In contrast, overexpression of USP19 increased cell invasiveness both in vitro and in vivo, further validating our findings."
33714979
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"USP19 overexpression enhances migration and invasion."
33714979
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"In our study, the cell invasion and migration induced by USP19 was correlated with MMP2 and MMP9 expression and enzyme activity."
32904569
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"In accordance with our previous results, the USP19 dependent increase in invasion is also determined by its catalytic activity and presence of the transmembrane domain."
33714979
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"Transwell assay showed that knockdown of USP19 decreased invasiveness of SGC7901 cells, whereas overexpression of USP19 enhanced GES1 cell invasion (P < 0.01; XREF_FIG and XREF_FIG, respectively)."
32904569
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"USP19 knockdown impairs invasion."
33714979
USP19 affects Interferon
| 9
USP19 inhibits Interferon.
| 7
USP19 inhibits Interferon. 7 / 7
| 7
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"USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination."
28391724
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"Furthermore, USP19 negatively regulates type I interferon (IFN) signaling and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation [27,28]."
| PMC
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"Previous studies have indicated that EV71 infection induces the up-regulation of USP19, which negatively regulates the antiviral type I interferon signalling by removing K-63 polyubiquitin chains from TRAF3 35."
30194441
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"Previously, it has been shown that USP19 negatively regulates RNA virus-triggered type I IFN induction by deubiquitinating Beclin-1 and impairing RIG-I-MAVS/VISA association in certain human cell lines ."
31511519
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"Furthermore, USP19 deficiency in macrophages caused an elevation of TBK1 and the activation of the type-I interferon signaling pathway after vesicular stomatitis virus (VSV) infection."
34436957
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"By removing K11 linked chains at K437 from Beclin-1, an essential factor of autophagic initiation, USP19 induces autophagy and inhibits the production of type I IFN [XREF_BIBR]."
33402098
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"The reduced expression of USP19 following MI and CHF could result in reduced autophagic response and could promote IFN signaling and NF-κB activation induced by tumor necrosis factor or interleukin 1β."
| PMC
USP19 activates Interferon.
| 2
USP19 activates Interferon. 2 / 2
| 2
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"Previously, it has been shown that USP19 negatively regulates RNA virus-triggered type I IFN induction by deubiquitinating Beclin-1 and impairing RIG-I-MAVS/VISA association in certain human cell lines ."
31511519
reach
"However, USP13, USP19, and USP22 inhibit virus-induced IFN production by removing K27-linked polyubiquitin chains from STING (40, 81) or TRIF (90)."
34707613
USP19 affects HDAC2
2 1 | 3 2
USP19 binds HDAC2.
2 | 3 2
USP19 binds HDAC2. 5 / 6
2 | 3
reach
"USP19 interacts with HDAC1 and HDAC2."
27517492
reach
"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19."
27517492
biogrid
No evidence text available
27517492
biogrid
No evidence text available
27517492
reach
"Of all the binding proteins, we found USP19 could interact with HDAC1 and HDAC2, which have been reported to play important roles in DNA damage repair."
27517492
USP19 binds HDAC1 and HDAC2. 2 / 2
| 2
sparser
"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19 (Figure xref and xref )."
27517492
sparser
"USP19 interacts with HDAC1 and HDAC2."
27517492
USP19 deubiquitinates HDAC2.
1 |
USP19 deubiquitinates HDAC2. 1 / 1
1 |
ubibrowser
"USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability"
27517492
USP19 affects HDAC1/2
| 7
USP19 binds HDAC1/2.
| 4
USP19 binds HDAC1/2. 3 / 5
| 3
reach
"USP19 physically interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair, chromosomal stability, and tumorigenesis, and USP19 expression is low or depleted in several types of tumors [32]."
| PMC
reach
"In addition, we also detected the association between HDAC1/2 and USP19 upon DNA damage both in exogenous and endogenous station."
27517492
reach
"To further confirm the interaction between USP19 and HDAC1/2, we transfected Flag tagged HDAC1 or HDAC2 together with Myc tagged USP19 into HEK293T cells and co-immunoprecipitaion experiment was performed."
27517492
USP19 binds HDAC1/2 and K63. 1 / 1
| 1
reach
"Importantly, we found that USP19 binds to HDAC1/2 and specifically regulating their K63 linked ubiquitination, which might be crucial for regulation of HDAC1/2 activity in DNA damage repair."
27517492
USP19 deubiquitinates HDAC1/2.
| 3
USP19 deubiquitinates HDAC1/2. 2 / 2
| 2
reach
"USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability."
27517492
reach
"USP19 physically interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair, chromosomal stability, and tumorigenesis, and USP19 expression is low or depleted in several types of tumors [32]."
| PMC
USP19 deubiquitinates HDAC1/2 on K63. 1 / 1
| 1
reach
"USP19 specifically deubiquitinates HDAC1/2 for their K63 linked ubiquitination."
27517492
EWSR1 affects USP19
| 9
USP19 binds EWSR1 and FLI1. 5 / 5
| 5
sparser
"It is therefore likely that EWS-FLI1 interacts with USP19 in the cytosol as the fusion protein displays a constant turnover and is shuffling in and out of the nucleus xref ."
30700749
sparser
"For this, we co-expressed myc-USP19 with 3xflag-EWS-FLI1 wild-type or mutants (K298R or K380R) and observed binding of USP19 to both EWS-FLI1 mutants, indicating that the interaction itself is independent of the presence of an ubiquitin chain (Fig.  xref )."
30700749
sparser
"Most interestingly, co-expression of active USP19 with EWS-FLI1 stabilized the fusion protein whereas full length EWSR1 and FLI1 protein levels remained unchanged even though binding of USP19 to both EWS-FLI1 and full length EWSR1 was observed in immunoprecipitation experiments."
30700749
sparser
"USP19 interacts with the N-terminal domain of EWS-FLI1 and full length EWSR1."
30700749
sparser
"More recently, USP19 was shown to deubiquitinate and stabilise EWS-FLI-1 fusions but not FLI-1, likely because USP19 bound to EWS-FLI-1 within N-terminal EWS sequences [ xref ]."
34066106
USP19 binds EWSR1. 2 / 2
| 2
sparser
"Importantly, stabilization appears to be specific for the fusion protein as it could not be observed neither for EWSR1 nor for FLI1 wild type proteins even though USP19 binds to the N-terminal EWS region to regulate deubiquitination of both EWS-FLI1 and EWSR1."
30700749
sparser
"USP19 binds to the EWSR1 domain of the fusion protein, as demonstrated by co-immunoprecipitation experiments, and reduces ubiquitination at an acceptor lysine site (the K380 residue xref ) in the FLI1 domain."
30700749
USP19 binds EWSR1, EWSR1, and FLI1. 1 / 1
| 1
sparser
"Strikingly, when USP19 was co-expressed with the full length proteins EWSR1 and FLI1, only full length EWSR1 but not wild type FLI1 could be immunoprecipitated indicating that USP19 binds to the N-terminal domain of EWSR1 and EWS-FLI1 (Fig.  xref )."
30700749
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
USP19 affects SIAH1
6 | 2
SIAH1 binds USP19. 8 / 8
6 | 2
biogrid
No evidence text available
22128162
biogrid
No evidence text available
27776223
biogrid
No evidence text available
23500468
reach
"To assess whether USP19 interacts with SIAH1 and SIAH2 in eukaryotic cells, HEK293T cells were co-transfected with plasmids expressing Myc-USP19 and HA-SIAH1 or HA-SIAH2 and cell lysates were subjecte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23500468
biogrid
No evidence text available
27776223
biogrid
No evidence text available
27776223
reach
"Probing Western blots of anti-Myc immunoprecipitates with an anti-HA antibody confirmed that USP19 interacts with both SIAH1 and SIAH2."
23500468
biogrid
No evidence text available
23500468
USP19 affects HSPA8
| 3 5
USP19 binds HSPA8. 6 / 6
| 3 3
reach
"USP19, a previously uncovered MAPS regulator binds HSC70 and acts upstream of HSC70 and DNAJC5."
29531792
sparser
"The observed interaction of USP19 with HSC70 prompted us to investigate whether DNAJC5–HSC70 uses the MAPS pathway to enhance Tau and α-Syn secretion."
29531792
sparser
"However, whether HSC70 interacts specifically with endogenous USP19 in untransfected cells was unclear."
29531792
reach
"However, whether HSC70 interacts specifically with endogenous USP19 in untransfected cells was unclear."
29531792
reach
"USP19 interacts with HSC70."
29531792
sparser
"USP19 interacts with HSC70."
29531792
TBK1 binds USP19 and HSPA8. 2 / 2
| 2
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression ."
34966378
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression (Zhao et al., 2021)."
34966378
USP19 affects HIF1A
2 | 1 4
USP19 binds HIF1A. 6 / 7
2 | 1 3
sparser
"It has been reported that USP19 interacts with HIF-1α and thereby prevents it from degradation xref ."
29162839
sparser
"Usp19 interacts with the N-terminus of HIF-1α which is also where the chaperone, Heat shock protein 90 (Hsp90), associates to stabilize HIF-1α (Fig. xref a)."
34045547
biogrid
No evidence text available
22128162
sparser
"USP19 interacts with HIF-1α and stabilizes HIF-1α, regardless of the ER localization and catalytic activity of USP19 in HeLa cells."
34201062
biogrid
No evidence text available
22128162
reach
"It has been reported that USP19 interacts with HIF-1alpha and thereby prevents it from degradation 29."
29162839
USP19 binds HIF1A and BHLH. 1 / 1
| 1
sparser
"This was based on findings showing that USP19 can interact with the bHLH-PAS domain of HIF-1α, but not HIF-2α, and with SIAH1 and SIAH2, which are known components of the hypoxia pathway since they regulate the presence of PHD 1/3 enzymes [ xref , xref ]."
31208103
USP19 affects BIRC3
3 1 | 3
USP19 binds BIRC3.
3 | 1
USP19 binds BIRC3. 4 / 5
3 | 1
biogrid
No evidence text available
21849505
biogrid
No evidence text available
21849505
biogrid
No evidence text available
21849505
reach
"Here we report that USP19, a deubiquitinating enzyme, interacts with cellular IAP 1 (c-IAP1) and c-IAP2."
21849505
USP19 activates BIRC3.
| 2
USP19 activates BIRC3. 2 / 2
| 2
reach
"For example, USP19 increased the stability of the cellular inhibitors of apoptosis 1 (c-IAP1) and c-IAP2 [XREF_BIBR]."
27129179
reach
"Furthermore, DUBs are known to regulate stability of only 4 of these proteins, including the ubiquitin ligases MARCH7 and BIRC3, which are targeted by USP7 or USP9 and USP19, respectively."
33417828
USP19 deubiquitinates BIRC3.
1 |
USP19 deubiquitinates BIRC3. 1 / 1
1 |
ubibrowser
No evidence text available
USP19 affects BECN1
1 | 4 2
USP19 deubiquitinates BECN1.
1 | 2
USP19 deubiquitinates BECN1. 3 / 3
1 | 2
reach
"Conversely, reversal of Beclin1 ubiquitylation by the DUB protein USP19 stabilized the protein under starvation conditions and promoted autophagy."
30333975
ubibrowser
"USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1"
26988033
reach
"USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1."
26988033
USP19 binds BECN1.
| 2
BECN1 binds USP19. 2 / 2
| 2
sparser
"The Beclin 1-ubiquitin-specific protease 19 (BECN1–USP19) axis, a positive regulator of autophagy initiation and progression, plays a role in the crosstalk between autophagy and retinoic acid-inducible gene I (RIG-I) -mediated type I interferon signaling [ xref ]."
31941042
sparser
"Therefore, the BECN1-USP19 axis is important in the crosstalk between autophagy and antiviral immune responses [ xref ]."
31001336
USP19 activates BECN1.
| 1
USP19 activates BECN1. 1 / 2
| 1
reach
"Beclin-1 stabilization is also promoted by USP19 and ataxin 3, which specifically removes K11- and K48-ubiquitin chain from Belcin-1, respectively [38, 39]."
31630678
USP19 ubiquitinates BECN1.
| 1
USP19 ubiquitinates BECN1. 1 / 1
| 1
reach
"USP19 affects DDX58/RIG-I-mediated type I interferon signaling through ubiquitinating BECN1 and promoting the formation of autophagosomes [62]."
32650621
SYVN1 affects USP19
1 | 2 3
USP19 binds SYVN1. 6 / 8
1 | 2 3
reach
"We reported that USP19 interacts with and targets HRD1 for the deubiquitination of K48 linked ubiquitin chains, the primary signal for proteasomal degradation [XREF_BIBR, XREF_BIBR] (XREF_FIG A and XREF_FIG A)."
27827840
sparser
"These results suggest that USP19 interacts with HRD1."
27827840
biogrid
No evidence text available
24356957
sparser
"However, there was no association between Myc-USP19 and FLAG-Nixin detected ( xref B), supporting the specificity of the USP19 interaction with HRD1."
27827840
reach
"These results suggest that USP19 interacts with HRD1."
27827840
sparser
"USP19 Interacts with HRD1."
27827840
HSPA8 affects USP19
| 3 5
USP19 binds HSPA8. 6 / 6
| 3 3
reach
"USP19, a previously uncovered MAPS regulator binds HSC70 and acts upstream of HSC70 and DNAJC5."
29531792
sparser
"The observed interaction of USP19 with HSC70 prompted us to investigate whether DNAJC5–HSC70 uses the MAPS pathway to enhance Tau and α-Syn secretion."
29531792
sparser
"However, whether HSC70 interacts specifically with endogenous USP19 in untransfected cells was unclear."
29531792
reach
"However, whether HSC70 interacts specifically with endogenous USP19 in untransfected cells was unclear."
29531792
reach
"USP19 interacts with HSC70."
29531792
sparser
"USP19 interacts with HSC70."
29531792
TBK1 binds USP19 and HSPA8. 2 / 2
| 2
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression ."
34966378
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression (Zhao et al., 2021)."
34966378
HIF1A affects USP19
2 | 1 4
USP19 binds HIF1A. 6 / 7
2 | 1 3
sparser
"It has been reported that USP19 interacts with HIF-1α and thereby prevents it from degradation xref ."
29162839
sparser
"Usp19 interacts with the N-terminus of HIF-1α which is also where the chaperone, Heat shock protein 90 (Hsp90), associates to stabilize HIF-1α (Fig. xref a)."
34045547
biogrid
No evidence text available
22128162
sparser
"USP19 interacts with HIF-1α and stabilizes HIF-1α, regardless of the ER localization and catalytic activity of USP19 in HeLa cells."
34201062
biogrid
No evidence text available
22128162
reach
"It has been reported that USP19 interacts with HIF-1alpha and thereby prevents it from degradation 29."
29162839
USP19 binds HIF1A and BHLH. 1 / 1
| 1
sparser
"This was based on findings showing that USP19 can interact with the bHLH-PAS domain of HIF-1α, but not HIF-2α, and with SIAH1 and SIAH2, which are known components of the hypoxia pathway since they regulate the presence of PHD 1/3 enzymes [ xref , xref ]."
31208103
HDAC2 affects USP19
2 | 3 2
USP19 binds HDAC2. 5 / 6
2 | 3
reach
"USP19 interacts with HDAC1 and HDAC2."
27517492
reach
"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19."
27517492
biogrid
No evidence text available
27517492
biogrid
No evidence text available
27517492
reach
"Of all the binding proteins, we found USP19 could interact with HDAC1 and HDAC2, which have been reported to play important roles in DNA damage repair."
27517492
USP19 binds HDAC1 and HDAC2. 2 / 2
| 2
sparser
"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19 (Figure xref and xref )."
27517492
sparser
"USP19 interacts with HDAC1 and HDAC2."
27517492
USP19 affects TBK1
| 5 2
USP19 inhibits TBK1.
| 3
USP19 inhibits TBK1. 3 / 3
| 3
reach
"Here, we demonstrate that USP19 (ubiquitin specific peptidase 19) interacts with and promotes TBK1 lysosomal degradation via chaperone-mediated autophagy (CMA)."
34436957
reach
"Furthermore, USP19 deficiency in macrophages caused an elevation of TBK1 and the activation of the type-I interferon signaling pathway after vesicular stomatitis virus (VSV) infection."
34436957
reach
"51 It has been reported further that USP19 promotes TBK1 degradation through chaperone-mediated autophagy.52 Severe acute respiratory syndrome coronavirus 2 M protein also interacts with TBK1 and induces TBK1 degradation by K48-linked ubiquitination."
35934222
USP19 binds TBK1.
| 2
TBK1 binds USP19 and HSPA8. 2 / 2
| 2
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression ."
34966378
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression (Zhao et al., 2021)."
34966378
USP19 activates TBK1.
| 2
USP19 activates TBK1. 2 / 2
| 2
reach
"We observed that TBK1 had a canonical CMA motif, knocking down key proteins involved in CMA (HSPA8/HSC70 or LAMP2A) or inhibiting CMA-prevented USP19-mediated TBK1 degradation."
34436957
reach
"USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy."
34436957
USP19 affects SIAH2
4 | 2 1
SIAH2 binds USP19. 7 / 7
4 | 2 1
sparser
"SIAH2 binds to USP19 and promotes USP19 ubiquitylation and proteasome‐dependent degradation xref ; then, the hypothesis of a causal link between SIAH2 and USP19 in cardiomyocyte hypertrophy was established: Decreased transcription of SIAH2 during hypertrophic progress led to less degradation of USP19, and this mechanism partially accounted for USP19 elevation."
32798288
biogrid
No evidence text available
22128162
reach
"Probing Western blots of anti-Myc immunoprecipitates with an anti-HA antibody confirmed that USP19 interacts with both SIAH1 and SIAH2."
23500468
reach
"To assess whether USP19 interacts with SIAH1 and SIAH2 in eukaryotic cells, HEK293T cells were co-transfected with plasmids expressing Myc-USP19 and HA-SIAH1 or HA-SIAH2 and cell lysates were subjecte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23500468
biogrid
No evidence text available
22128162
biogrid
No evidence text available
23500468
biogrid
No evidence text available
23500468
USP19 affects PAH
| 6 1
USP19 deubiquitinates PAH.
| 2
USP19 deubiquitinates PAH. 2 / 2
| 2
reach
"Our study indicates that USP19 interacts with PAH and prevents polyubiquitination of PAH subsequently extending the half-life of PAH protein."
35449354
reach
"USP19 deubiquitinates and stabilizes PAH further protecting it from rapid degradation."
35449354
USP19 activates PAH.
| 2
USP19 activates PAH. 2 / 2
| 2
reach
"The deubiquitinating activity of USP19 prevents protein degradation and increases the abundance of both PAH protein variants."
35987969
reach
"USP19 increases the enzymatic activity of PAH, thus maintaining normal Phe levels."
35449354
USP19 inhibits PAH.
| 1
USP19 inhibits PAH. 1 / 1
| 1
reach
"We found that ectopic expression of USP19 increased PAH protein level, whereas depletion of USP19 promoted PAH protein degradation."
35449354
USP19 increases the amount of PAH.
| 1
USP19 increases the amount of PAH. 1 / 1
| 1
reach
"We found that ectopic expression of USP19 increased PAH protein level, whereas depletion of USP19 promoted PAH protein degradation."
35449354
USP19 binds PAH.
| 1
USP19 binds PAH. 1 / 1
| 1
sparser
"Our study indicates that USP19 interacts with PAH and prevents polyubiquitination of PAH subsequently extending the half-life of PAH protein."
35449354
USP19 affects LRP6
1 | 4 1
USP19 activates LRP6.
| 2
USP19 activates LRP6. 2 / 3
| 2
reach
"USP19 promotes LRP6 biogenesis and controls Wnt signaling."
27751231
reach
"Finally, these observations demonstrate that USP19 promotes the biogenesis of LRP6, with only 18% of newly synthesized LRP6 molecules surviving beyond 6 hr in the absence of USP19 and 60% surviving upon USP19 overexpression."
27751231
USP19 deubiquitinates LRP6.
1 | 1
USP19 deubiquitinates LRP6. 2 / 2
1 | 1
ubibrowser
"We show that folding of the Wnt signaling coreceptor LRP6 is promoted by ubiquitination of a specific lysine, retaining it in the ER while avoiding degradation. Subsequent ER exit requires removal of ubiquitin from this lysine by the deubiquitinating enzyme USP19."
27751231
reach
"Upon release from this putative ubiquitin binding chaperone, LRP6 is deubiquitinated by USP19."
27751231
USP19 binds LRP6.
| 1 1
USP19 binds LRP6. 2 / 2
| 1 1
reach
"Consequently, our results indicate that the functional interaction between USP19 and LRP6 is key for the regulatory effect that USP19 exerts on the modulation of breast cancer cell migration and invasion."
33714979
sparser
"Consequently, our results indicate that the functional interaction between USP19 and LRP6 is key for the regulatory effect that USP19 exerts on the modulation of breast cancer cell migration and invasion."
33714979
USP19 affects HSP90AA1
7 |
biogrid
No evidence text available
26808260
biogrid
No evidence text available
19875381
biogrid
No evidence text available
26808260
biogrid
No evidence text available
24356957
biogrid
No evidence text available
24356957
biogrid
No evidence text available
24356957
biogrid
No evidence text available
26808260
USP19 affects HSP90
| 3 4
HSP90 binds USP19. 7 / 7
| 3 4
sparser
"Collectively, the cytoplasmic USP19 associates with HSP90 potentially forming a dynamic complex in cells, which may function in quality control for the polyQ-expanded proteins."
26808260
sparser
"This suggests that the Hsp90–Usp19 complex can simultaneously mobilize two dcTPR proteins via their MEEVD C termini."
30410862
sparser
"Both forms of USP19 specifically interact with HSP90 through their N-terminal CS domains and then associate with CHIP via HSP90."
26808260
reach
"Thus, HSP90 interacts with Htt-N90 on the N-terminal amphipathic alpha-helix, and then recruits USP19 to modulate the protein level and aggregation of Htt-N90."
29093475
reach
"This suggests that the Hsp90–Usp19 complex can simultaneously mobilize two dcTPR proteins via their MEEVD C termini."
30410862
reach
"However, when the TM domain was removed, the C-terminal (CT) fragment of USP19 could now bind Hsp90 almost as efficiently as full-length WT USP19."
29531792
sparser
"The regulatory function of USP19 was recently confirmed in a study demonstrating that USP19 interacts directly with chaperone Hsp90 and upregulates the aggregation of poly-Q containing the proteins Ataxin-3 and Huntingtin, which causes spinocerebellar ataxia type-3 and Huntington’s disease, respectively [ xref ]."
32679806
USP19 affects FUNDC1
| 2 5
USP19 binds FUNDC1.
| 1 5
USP19 binds FUNDC1. 6 / 6
| 1 5
sparser
"In addition, USP19 (an ER-resident deubiquitinase) can bind FUNDC1 and deubiquitinate it at the MAMs leading to DRP1 oligomerization and promotion of mitochondrial division ( xref )."
35096821
reach
"In response to hypoxia, USP19 binds to and deubiquitinates FUNDC1 at ER-mitochondria contact sites, which facilitates Drp1 oligomerization and Drp1 GTP binding and hydrolysis activities, thereby promoting mitochondrial division."
33978709
sparser
"Furthermore, using immunoprecipitation coupled with pull-down assays, the investigation has confirmed that USP19 directly binds to FUNDC1, and that the interaction is strongly enhanced under hypoxic conditions ( xref ) ( xref )."
35281107
sparser
"As hypoxia progresses, FUNDC1 may preferably bind to USP19, which deubiquitinates and stabilizes FUNDC1 at MERCSs, as a result, mitochondrial fission is initiated, and mitophagy is promoted to eliminate damage mitochondria ( xref ) ( xref )."
35281107
sparser
"In response to hypoxia, USP19 binds to and deubiquitinates FUNDC1 at ER-mitochondria contact sites, which facilitates Drp1 oligomerization and Drp1 GTP-binding and hydrolysis activities, thereby promoting mitochondrial division."
33978709
sparser
"The interaction between USP19 and its substrate FUNDC1 is also verified by co-immunoprecipitation assays and glutathione S- transferase (GST) affinity isolation assays ( xref )."
35281107
USP19 deubiquitinates FUNDC1.
| 1
USP19 deubiquitinates FUNDC1. 1 / 1
| 1
reach
"In response to hypoxia, USP19 binds to and deubiquitinates FUNDC1 at ER-mitochondria contact sites, which facilitates Drp1 oligomerization and Drp1 GTP binding and hydrolysis activities, thereby promoting mitochondrial division."
33978709
USP19 affects FLI1
| 7
USP19 binds EWSR1 and FLI1. 5 / 5
| 5
sparser
"It is therefore likely that EWS-FLI1 interacts with USP19 in the cytosol as the fusion protein displays a constant turnover and is shuffling in and out of the nucleus xref ."
30700749
sparser
"For this, we co-expressed myc-USP19 with 3xflag-EWS-FLI1 wild-type or mutants (K298R or K380R) and observed binding of USP19 to both EWS-FLI1 mutants, indicating that the interaction itself is independent of the presence of an ubiquitin chain (Fig.  xref )."
30700749
sparser
"Most interestingly, co-expression of active USP19 with EWS-FLI1 stabilized the fusion protein whereas full length EWSR1 and FLI1 protein levels remained unchanged even though binding of USP19 to both EWS-FLI1 and full length EWSR1 was observed in immunoprecipitation experiments."
30700749
sparser
"USP19 interacts with the N-terminal domain of EWS-FLI1 and full length EWSR1."
30700749
sparser
"More recently, USP19 was shown to deubiquitinate and stabilise EWS-FLI-1 fusions but not FLI-1, likely because USP19 bound to EWS-FLI-1 within N-terminal EWS sequences [ xref ]."
34066106
USP19 binds EWSR1, EWSR1, and FLI1. 1 / 1
| 1
sparser
"Strikingly, when USP19 was co-expressed with the full length proteins EWSR1 and FLI1, only full length EWSR1 but not wild type FLI1 could be immunoprecipitated indicating that USP19 binds to the N-terminal domain of EWSR1 and EWS-FLI1 (Fig.  xref )."
30700749
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
USP19 affects CDKN1B
| 6
USP19 activates CDKN1B.
| 3
USP19 activates CDKN1B. 3 / 4
| 3
reach
"Indeed, in cells transfected with USP19 siRNA p27 Kip1 levels remained relatively stable over time whereas the half-life of the protein was significantly lower in controls (XREF_FIG), implying that USP19 modulates the stability of p27 Kip1."
21264218
reach
"Although p27 Kip1 mRNA levels remain unchanged upon USP19 depletion (XREF_FIG), it remains possible that p27 Kip1 synthesis is regulated also at the level of translation and that USP19 modulates such translational efficiency of p27 Kip1 mRNA."
21264218
reach
"This increased p27 Kip1 induced by USP19 depletion did not appear to be due to increased gene transcription, as Northern blot analysis revealed that p27 Kip1 mRNA levels did not change (XREF_FIG)."
21264218
USP19 inhibits CDKN1B.
| 2
USP19 inhibits CDKN1B. 2 / 2
| 2
reach
"In their model, USP19 stabilizes KPC1 and thus indirectly promotes degradation of p27 KIP1 in the cytoplasm."
19277118
reach
"USP19 deubiquitinates and thereby stabilizes the KPC1 ligase for p27 Kip1, and so indirectly promotes degradation of p27 Kip1 and subsequent cell proliferation."
21264218
USP19 deubiquitinates CDKN1B.
| 1
USP19 deubiquitinates CDKN1B. 1 / 1
| 1
reach
"USP19 deubiquitinates and stabilizes KPC1, an E3 ligase for p27."
34660907
USP19 is modified
5 | 2
USP19 is phosphorylated.
4 |
USP19 is phosphorylated on S244. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
15302935
USP19 is phosphorylated on S406. 1 / 1
1 |
hprd
No evidence text available
20068231
USP19 is phosphorylated on T407. 1 / 1
1 |
hprd
No evidence text available
18669648
USP19 is ubiquitinated.
| 2
USP19 is ubiquitinated. 2 / 2
| 2
sparser
"The interaction is mediated by a SIAH-consensus binding motif and promotes USP19 ubiquitylation and proteasome-dependent degradation."
23500468
sparser
"Previous study has been reported that SIAH2 is a binding partner of USP19 and promotes USP19 ubiquitylation and proteasome‐dependent degradation xref ; thus, we hypothesize USP19 may be regulated by SIAH2 in response to cardiac hypertrophy stimulation."
32798288
USP19 is acetylated.
1 |
USP19 is acetylated on S2. 1 / 1
1 |
hprd
No evidence text available
19413330
HSP90AA1 affects USP19
7 |
biogrid
No evidence text available
26808260
biogrid
No evidence text available
19875381
biogrid
No evidence text available
26808260
biogrid
No evidence text available
24356957
biogrid
No evidence text available
24356957
biogrid
No evidence text available
24356957
biogrid
No evidence text available
26808260
HSP90 affects USP19
| 3 4
HSP90 binds USP19. 7 / 7
| 3 4
sparser
"Collectively, the cytoplasmic USP19 associates with HSP90 potentially forming a dynamic complex in cells, which may function in quality control for the polyQ-expanded proteins."
26808260
sparser
"This suggests that the Hsp90–Usp19 complex can simultaneously mobilize two dcTPR proteins via their MEEVD C termini."
30410862
sparser
"Both forms of USP19 specifically interact with HSP90 through their N-terminal CS domains and then associate with CHIP via HSP90."
26808260
reach
"Thus, HSP90 interacts with Htt-N90 on the N-terminal amphipathic alpha-helix, and then recruits USP19 to modulate the protein level and aggregation of Htt-N90."
29093475
reach
"This suggests that the Hsp90–Usp19 complex can simultaneously mobilize two dcTPR proteins via their MEEVD C termini."
30410862
reach
"However, when the TM domain was removed, the C-terminal (CT) fragment of USP19 could now bind Hsp90 almost as efficiently as full-length WT USP19."
29531792
sparser
"The regulatory function of USP19 was recently confirmed in a study demonstrating that USP19 interacts directly with chaperone Hsp90 and upregulates the aggregation of poly-Q containing the proteins Ataxin-3 and Huntingtin, which causes spinocerebellar ataxia type-3 and Huntington’s disease, respectively [ xref ]."
32679806
FLI1 affects USP19
| 7
USP19 binds EWSR1 and FLI1. 5 / 5
| 5
sparser
"It is therefore likely that EWS-FLI1 interacts with USP19 in the cytosol as the fusion protein displays a constant turnover and is shuffling in and out of the nucleus xref ."
30700749
sparser
"For this, we co-expressed myc-USP19 with 3xflag-EWS-FLI1 wild-type or mutants (K298R or K380R) and observed binding of USP19 to both EWS-FLI1 mutants, indicating that the interaction itself is independent of the presence of an ubiquitin chain (Fig.  xref )."
30700749
sparser
"Most interestingly, co-expression of active USP19 with EWS-FLI1 stabilized the fusion protein whereas full length EWSR1 and FLI1 protein levels remained unchanged even though binding of USP19 to both EWS-FLI1 and full length EWSR1 was observed in immunoprecipitation experiments."
30700749
sparser
"USP19 interacts with the N-terminal domain of EWS-FLI1 and full length EWSR1."
30700749
sparser
"More recently, USP19 was shown to deubiquitinate and stabilise EWS-FLI-1 fusions but not FLI-1, likely because USP19 bound to EWS-FLI-1 within N-terminal EWS sequences [ xref ]."
34066106
USP19 binds EWSR1, EWSR1, and FLI1. 1 / 1
| 1
sparser
"Strikingly, when USP19 was co-expressed with the full length proteins EWSR1 and FLI1, only full length EWSR1 but not wild type FLI1 could be immunoprecipitated indicating that USP19 binds to the N-terminal domain of EWSR1 and EWS-FLI1 (Fig.  xref )."
30700749
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
USP19 affects Ubiquitin
| 3 3
USP19 binds Ubiquitin.
| 3
sparser
"For instance, the full activation of USP19 requires its interaction with Hsp90, which promotes the binding of ubiquitin to the catalytic domain of USP19 [ xref ]."
30126257
sparser
"For instance, the full activation of USP19 requires its interaction with Hsp90, which promotes the binding of ubiquitin to the catalytic domain of USP19 [173]."
30126257
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
USP19 inhibits Ubiquitin.
| 2
USP19 inhibits Ubiquitin. 2 / 2
| 2
reach
"RNF216 interacts with and ubiquitinates Beclin 1 at lysine 48, thereby contributing to Beclin 1 degradation, while SLC9A3R1 and USP19 blocks ubiquitin dependent Beclin 1 degradation by interacting with Beclin 1 and removing the K11 linked ubiquitin respectively."
33425768
reach
"Taken together, USP19 suppresses pTh17 differentiation and pathogenic potential through the removal of K63-linked ubiquitin chain from lysine 313 of RORγt, which is required for recruiting coactivator SRC3 and essential for the expression of proinflammatory effectors (Fig. 6E)."
34135062
USP19 activates Ubiquitin.
| 1
USP19 activates Ubiquitin. 1 / 1
| 1
reach
"The interaction of USP19 with substrates causes the removal of ubiquitin chains, which facilitates the export of MAPS substrates 3."
29531792
USP19 affects RNF123
1 | 4
USP19 deubiquitinates RNF123.
1 | 2
USP19 deubiquitinates RNF123. 3 / 3
1 | 2
reach
"USP19 deubiquitinates and stabilizes KPC1, an E3 ligase for p27."
34660907
ubibrowser
"USP19 deubiquitinates Kip1 ubiquitination-promoting complex protein 1 (KPC1) regulating p27Kip1"
25121098
reach
"USP19 deubiquitinates and stabilizes KPC1, an E3 ligase for p27."
25605410
USP19 activates RNF123.
| 2
USP19 activates RNF123. 2 / 3
| 2
reach
"USP19 in turn also contributes to p27 degradation by stabilizing KPC1 [70]."
30241373
reach
"USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1."
19015242
USP19 affects Mhc
| 6
USP19 increases the amount of Mhc.
| 4
USP19 increases the amount of Mhc. 4 / 4
| 4
reach
"USP19 depletion also increased MHC and tropomyosin mRNA levels, suggesting that this effect is due to increased transcription."
19773579
reach
"Depletion of all isoforms of USP19 increased myogenin (XREF_FIG) and tropomyosin and MHC protein levels (XREF_FIG), as previously reported, and enhanced myotube formation and fusion (XREF_FIG)."
25568336
reach
"USP19 depletion also increased MHC and tropomyosin mRNA levels, suggesting that this effect is due to increased transcription."
22477519
reach
"Mutant forms of USP19 lacking deubiquitinating activity increased MHC and tropomyosin levels."
21971047
USP19 activates Mhc.
| 2
USP19 activates Mhc. 2 / 2
| 2
reach
"USP19 siRNA reversed the suppression of MHC by these agents."
22477519
reach
"Depletion of USP19 reversed the dexamethasone suppression of MHC."
19773579
USP19 affects MYOG
| 6
USP19 increases the amount of MYOG.
| 3
USP19 increases the amount of MYOG. 3 / 3
| 3
reach
"The ability of USP19 to modulate expression of myogenin suggests that it might also be involved in myogenesis."
23680672
reach
"The USP19 deubiquitinating enzyme modulates the expression of myogenin and myofibrillar proteins in L6 muscle cells."
25568336
reach
"Only the ER localized isoform of USP19 (USP19-ER) modulated myoblast fusion as well as the expression of myogenin and myofibrillar proteins, and these effects were also dependent on USP19 catalytic activity."
25568336
USP19 inhibits MYOG.
| 1
USP19 inhibits MYOG. 1 / 1
| 1
reach
"They found that a decrease of USP19 promoted muscle cell fusion and increased myotube diameter and expressions of myogenin and myosin heavy chain."
24595460
USP19 decreases the amount of MYOG.
| 1
USP19 decreases the amount of MYOG. 1 / 1
| 1
reach
"USP19 inhibits fusion of L6 myoblasts and expression of myogenin and major myofibrillar proteins."
25568336
USP19 activates MYOG.
| 1
USP19 activates MYOG. 1 / 1
| 1
reach
"Our previous observations that silencing USP19 induced expression of myofibrillar proteins as well as myogenin in muscle cells suggested that USP19 might modulate muscle cell differentiation."
25568336
USP19 affects MMP9
| 6
USP19 increases the amount of MMP9.
| 5
USP19 increases the amount of MMP9. 4 / 4
| 4
reach
"Our study suggests that USP19 promoted tumor progression by inducing MMP2 and MMP9 expression and related enzyme activity."
32904569
reach
"Our results first indicated that USP19 enhanced MMP2 and MMP9 protein expression as well as enzyme activity."
32904569
reach
"We first found overexpressing USP19 increased MMP2 and MMP9 protein levels."
32904569
reach
"Moreover, the ability of USP19 to enhance the migratory and invasive abilities of GC cells by increasing MMP2 and MMP9 expression was evaluated using gelatin zymography."
32904569
Modified USP19 increases the amount of MMP9. 1 / 1
| 1
reach
"Overexpression of USP19 enhanced MMP2 and MMP9 protein expression and enzyme activity."
32904569
USP19 activates MMP9.
| 1
USP19 activates MMP9. 1 / 1
| 1
reach
"USP19 Enhances MMP2 and MMP9 Mediated Tumorigenesis in Gastric Cancer."
32904569
MARCHF6 affects USP19
| 3 2
USP19 binds MARCHF6. 5 / 6
| 3 2
reach
"Here, we show that USP19 interacts with the ERAD associated E3 ubiquitin ligase MARCH6."
25088257
reach
"Since transmembrane USP19 and MARCH6 have been shown to be localized to the ER, we first assessed the possibility that USP19 interacts with MARCH6."
25088257
sparser
"Since transmembrane USP19 and MARCH6 have been shown to be localized to the ER, we first assessed the possibility that USP19 interacts with MARCH6."
25088257
sparser
"Here, we show that USP19 interacts with the ERAD-associated E3 ubiquitin ligase MARCH6."
25088257
reach
"We found that USP19 also interacts with and stabilizes MARCH6."
25088257
HDAC1/2 affects USP19
| 4
USP19 binds HDAC1/2. 3 / 5
| 3
reach
"USP19 physically interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair, chromosomal stability, and tumorigenesis, and USP19 expression is low or depleted in several types of tumors [32]."
| PMC
reach
"In addition, we also detected the association between HDAC1/2 and USP19 upon DNA damage both in exogenous and endogenous station."
27517492
reach
"To further confirm the interaction between USP19 and HDAC1/2, we transfected Flag tagged HDAC1 or HDAC2 together with Myc tagged USP19 into HEK293T cells and co-immunoprecipitaion experiment was performed."
27517492
USP19 binds HDAC1/2 and K63. 1 / 1
| 1
reach
"Importantly, we found that USP19 binds to HDAC1/2 and specifically regulating their K63 linked ubiquitination, which might be crucial for regulation of HDAC1/2 activity in DNA damage repair."
27517492
FUNDC1 affects USP19
| 1 5
USP19 binds FUNDC1. 6 / 6
| 1 5
sparser
"In addition, USP19 (an ER-resident deubiquitinase) can bind FUNDC1 and deubiquitinate it at the MAMs leading to DRP1 oligomerization and promotion of mitochondrial division ( xref )."
35096821
reach
"In response to hypoxia, USP19 binds to and deubiquitinates FUNDC1 at ER-mitochondria contact sites, which facilitates Drp1 oligomerization and Drp1 GTP binding and hydrolysis activities, thereby promoting mitochondrial division."
33978709
sparser
"Furthermore, using immunoprecipitation coupled with pull-down assays, the investigation has confirmed that USP19 directly binds to FUNDC1, and that the interaction is strongly enhanced under hypoxic conditions ( xref ) ( xref )."
35281107
sparser
"As hypoxia progresses, FUNDC1 may preferably bind to USP19, which deubiquitinates and stabilizes FUNDC1 at MERCSs, as a result, mitochondrial fission is initiated, and mitophagy is promoted to eliminate damage mitochondria ( xref ) ( xref )."
35281107
sparser
"In response to hypoxia, USP19 binds to and deubiquitinates FUNDC1 at ER-mitochondria contact sites, which facilitates Drp1 oligomerization and Drp1 GTP-binding and hydrolysis activities, thereby promoting mitochondrial division."
33978709
sparser
"The interaction between USP19 and its substrate FUNDC1 is also verified by co-immunoprecipitation assays and glutathione S- transferase (GST) affinity isolation assays ( xref )."
35281107
EWSR1 affects FLI1, and USP19
| 6
USP19 binds EWSR1 and FLI1. 5 / 5
| 5
sparser
"It is therefore likely that EWS-FLI1 interacts with USP19 in the cytosol as the fusion protein displays a constant turnover and is shuffling in and out of the nucleus xref ."
30700749
sparser
"For this, we co-expressed myc-USP19 with 3xflag-EWS-FLI1 wild-type or mutants (K298R or K380R) and observed binding of USP19 to both EWS-FLI1 mutants, indicating that the interaction itself is independent of the presence of an ubiquitin chain (Fig.  xref )."
30700749
sparser
"Most interestingly, co-expression of active USP19 with EWS-FLI1 stabilized the fusion protein whereas full length EWSR1 and FLI1 protein levels remained unchanged even though binding of USP19 to both EWS-FLI1 and full length EWSR1 was observed in immunoprecipitation experiments."
30700749
sparser
"USP19 interacts with the N-terminal domain of EWS-FLI1 and full length EWSR1."
30700749
sparser
"More recently, USP19 was shown to deubiquitinate and stabilise EWS-FLI-1 fusions but not FLI-1, likely because USP19 bound to EWS-FLI-1 within N-terminal EWS sequences [ xref ]."
34066106
USP19 binds EWSR1, EWSR1, and FLI1. 1 / 1
| 1
sparser
"Strikingly, when USP19 was co-expressed with the full length proteins EWSR1 and FLI1, only full length EWSR1 but not wild type FLI1 could be immunoprecipitated indicating that USP19 binds to the N-terminal domain of EWSR1 and EWS-FLI1 (Fig.  xref )."
30700749
USP19 affects poly(I:C)
| 5
USP19 inhibits poly(I:C). 3 / 3
| 3
reach
"Overexpression of USP19 inhibited poly(I:C)- and LPS-induced activation of NF-κB and IRF3, whereas USP19-deficiency had the opposite effects."
31511519
reach
"These results suggest that overexpression of USP19 inhibits poly(I:C)- and LPS-triggered IRF3 and NF-κB activation.We next examined the role of endogenous USP19 in regulation of TLR3/4-mediated signaling."
31511519
reach
"Deficiency of USP19 increased serum cytokine levels after administration of poly(I:C) and LPS, and promoted inflammatory death caused by administration of poly(I:C) or LPS, or infection of Salmonella typhimurium."
31511519
USP19-C607S inhibits poly(I:C). 2 / 2
| 2
reach
"Consistently, USP19 but not USP19(C607S) inhibited poly(I:C)- and LPS-induced activation of the IFN-β promoter in reporter assays (Supplementary Fig. 4a)."
31511519
reach
"Reconstitution of USP19 but not USP19 (C607S) into Usp19 MLFs inhibited poly(I:C)- and LPS-induced transcription of Ifnb1 and Cxcl10 (Supplementary Fig. 4b)."
31511519
USP19 affects Non-structural protein 5A
5 |
virhostnet
No evidence text available
18985028
virhostnet
No evidence text available
18985028
virhostnet
No evidence text available
24169621
virhostnet
No evidence text available
25616068
virhostnet
No evidence text available
25616068
USP19 affects MMP2
| 5
USP19 increases the amount of MMP2.
| 4
USP19 increases the amount of MMP2. 4 / 4
| 4
reach
"Our results first indicated that USP19 enhanced MMP2 and MMP9 protein expression as well as enzyme activity."
32904569
reach
"Our study suggests that USP19 promoted tumor progression by inducing MMP2 and MMP9 expression and related enzyme activity."
32904569
reach
"Moreover, the ability of USP19 to enhance the migratory and invasive abilities of GC cells by increasing MMP2 and MMP9 expression was evaluated using gelatin zymography."
32904569
reach
"We first found overexpressing USP19 increased MMP2 and MMP9 protein levels."
32904569
USP19 activates MMP2.
| 1
USP19 activates MMP2. 1 / 1
| 1
reach
"USP19 Enhances MMP2 and MMP9 Mediated Tumorigenesis in Gastric Cancer."
32904569
USP19 affects DERL1
1 | 1 3
USP19 binds DERL1. 5 / 5
1 | 1 3
sparser
"Intriguingly, although overexpressed USP19 interacts with Derlin-1 and other ERAD machinery factors in the membrane, endogenous USP19 is mostly in the cytosol where it binds Hsp90."
24356957
sparser
"Accordingly, we detect neither interaction of endogenous USP19 with Derlin-1 nor significant effect on ERAD by USP19 depletion."
24356957
sparser
"It was shown that USP19 can interact with Derlin-1 and overexpression of wild type USP19 can inhibit the degradation of a few model ERAD substrates."
22812527
biogrid
No evidence text available
24356957
reach
"It was shown that USP19 can interact with Derlin-1 and overexpression of wild type USP19 can inhibit the degradation of a few model ERAD substrates."
22812527
USP19 affects CFTR
1 | 4
USP19 activates CFTR.
| 4
USP19 activates CFTR. 4 / 4
| 4
reach
"In preceding studies the ER localised USP19 was shown to rescue the ERAD substrates cystic fibrosis transmembrane conductance regulator (CFTR) DeltaF508 and T-cell receptor-alpha (TCRalpha) from proteasomal degradation 109."
28064438
reach
"Interestingly, USP19 is a target gene of the unfolded protein response (UPR) and was found to rescue CFTR DeltaF508 from ERAD."
27751231
reach
"USP19 was reported to rescue the CFTR Delta508 mutant, which is an ERAD substrate."
27751231
reach
"USP19 rescues the ERAD substrates cystic fibrosis transmembrane conductance regulator (CFTR) DeltaF508 and T-cell receptor-alpha (TCRalpha) from proteasomal degradation."
19465887
USP19 binds CFTR.
1 |
USP19 binds CFTR. 1 / 1
1 |
biogrid
No evidence text available
19465887
USP19 affects BIRC2
1 1 | 2
USP19 binds BIRC2.
1 | 1
USP19 binds BIRC2. 2 / 3
1 | 1
biogrid
No evidence text available
21849505
reach
"Here we report that USP19, a deubiquitinating enzyme, interacts with cellular IAP 1 (c-IAP1) and c-IAP2."
21849505
USP19 inhibits BIRC2.
| 1
USP19 inhibits BIRC2. 1 / 1
| 1
reach
"For example, USP19 increased the stability of the cellular inhibitors of apoptosis 1 (c-IAP1) and c-IAP2 [XREF_BIBR]."
27129179
USP19 deubiquitinates BIRC2.
1 |
USP19 deubiquitinates BIRC2. 1 / 1
1 |
ubibrowser
No evidence text available
USP19 affects ATXN3
| 5
USP19 activates ATXN3. 5 / 5
| 5
reach
"We next examined the effect of usp19 silencing on the protein levels of Atx3 100Q and Htt-N552 100Q, and observed that knockdown of USP19 significantly reduced the protein levels of Atx3 100Q (XREF_FIG) and Htt-N552 100Q (XREF_FIG) both in HEK 293T cells and in human retinal pigment epithelial (RPE1) cells (XREF_SUPPLEMENTARY)."
26808260
reach
"Beclin-1 stabilization is also promoted by USP19 and ataxin 3, which specifically removes K11- and K48-ubiquitin chain from Belcin-1, respectively [38, 39]."
31630678
reach
"The major finding of this work is that cytoplasmic USP19 can promote aggregation of the polyQ expanded Atx3 and Htt proteins by up-regulating their protein levels."
26808260
reach
"The regulatory function of USP19 was recently confirmed in a study demonstrating that USP19 interacts directly with chaperone Hsp90 and upregulates the aggregation of poly-Q containing the proteins Ataxin-3 and Huntingtin, which causes spinocerebellar ataxia type-3 and Huntington’s disease, respectively [90]."
32679806
reach
"Cytoplasmic Ubiquitin Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone."
26808260
USP19 affects AIP
2 | 1 2
USP19 binds AIP. 3 / 3
2 | 1
biogrid
No evidence text available
25036637
reach
"AIP interactions with Usp19, DNAAF2, NADSYN1, p23, Hsp105, and BclG are shown in Fig. 4C and FKBP51 interactions with these proteins were found to be similar to those of AIP (not shown)."
30410862
biogrid
No evidence text available
25036637
USP19 binds AIP and FKBP51. 1 / 1
| 1
sparser
"We confirmed interaction of ubiquitin carboxypeptidase Usp19 with two dcTPR proteins, AIP and FKBP51, via the dicarboxylate clamp mechanism."
30410862
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
Non-structural protein 5A affects USP19
5 |
virhostnet
No evidence text available
18985028
virhostnet
No evidence text available
18985028
virhostnet
No evidence text available
24169621
virhostnet
No evidence text available
25616068
virhostnet
No evidence text available
25616068
E2 affects USP19
| 5
E2 increases the amount of USP19. 5 / 5
| 5
reach
"Furthermore, in skeletal muscle satellite cells, E2 inhibited myogenesis and increased USP19 expression, and diarylpropionitrile repressed E2 increased USP19 expression."
21971047
reach
"Propylpyrazole-triol increased USP19 expression, and ICI 182,780 inhibited E2 increased USP19 expression."
21971047
reach
"E2 replacement increased USP19 expression in the gastrocnemius and soleus muscles of ovariectomized mice."
21971047
reach
"These results demonstrate that in soleus muscle in young female mice under physiological conditions, E2 upregulates USP19 expression through ERalpha and consequently leads to decreases in ubiquitin conjugates and muscle mass."
25901042
reach
"E2 induced ubiquitin specific peptidase 19 (USP19) expression during myogenesis."
21971047
DERL1 affects USP19
1 | 1 3
USP19 binds DERL1. 5 / 5
1 | 1 3
sparser
"Intriguingly, although overexpressed USP19 interacts with Derlin-1 and other ERAD machinery factors in the membrane, endogenous USP19 is mostly in the cytosol where it binds Hsp90."
24356957
sparser
"Accordingly, we detect neither interaction of endogenous USP19 with Derlin-1 nor significant effect on ERAD by USP19 depletion."
24356957
sparser
"It was shown that USP19 can interact with Derlin-1 and overexpression of wild type USP19 can inhibit the degradation of a few model ERAD substrates."
22812527
biogrid
No evidence text available
24356957
reach
"It was shown that USP19 can interact with Derlin-1 and overexpression of wild type USP19 can inhibit the degradation of a few model ERAD substrates."
22812527
BIRC3 affects USP19
3 | 1
USP19 binds BIRC3. 4 / 5
3 | 1
biogrid
No evidence text available
21849505
biogrid
No evidence text available
21849505
biogrid
No evidence text available
21849505
reach
"Here we report that USP19, a deubiquitinating enzyme, interacts with cellular IAP 1 (c-IAP1) and c-IAP2."
21849505
AIP affects USP19
2 | 1 2
USP19 binds AIP. 3 / 3
2 | 1
biogrid
No evidence text available
25036637
reach
"AIP interactions with Usp19, DNAAF2, NADSYN1, p23, Hsp105, and BclG are shown in Fig. 4C and FKBP51 interactions with these proteins were found to be similar to those of AIP (not shown)."
30410862
biogrid
No evidence text available
25036637
USP19 binds AIP and FKBP51. 1 / 1
| 1
sparser
"We confirmed interaction of ubiquitin carboxypeptidase Usp19 with two dcTPR proteins, AIP and FKBP51, via the dicarboxylate clamp mechanism."
30410862
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
Bisphenol A affects USP19
4 |
Bisphenol A increases the amount of USP19.
2 |
Bisphenol A increases the amount of USP19. 2 / 2
2 |
ctd
No evidence text available
30816183
ctd
No evidence text available
25181051
Bisphenol A demethylates USP19.
2 |
Bisphenol A demethylates USP19. 2 / 2
2 |
ctd
No evidence text available
27312807
ctd
No evidence text available
30906313
USP19 affects tropomyosin
| 4
USP19 increases the amount of tropomyosin. 4 / 4
| 4
reach
"USP19 depletion also increased MHC and tropomyosin mRNA levels, suggesting that this effect is due to increased transcription."
22477519
reach
"USP19 depletion also increased MHC and tropomyosin mRNA levels, suggesting that this effect is due to increased transcription."
19773579
reach
"Mutant forms of USP19 lacking deubiquitinating activity increased MHC and tropomyosin levels."
21971047
reach
"Depletion of all isoforms of USP19 increased myogenin (XREF_FIG) and tropomyosin and MHC protein levels (XREF_FIG), as previously reported, and enhanced myotube formation and fusion (XREF_FIG)."
25568336
USP19 affects proteolysis
| 4
USP19 activates proteolysis. 4 / 4
| 4
reach
"USP19 suppresses protein synthesis and enhances protein degradation (ubiquitin proteasome system and autophagy) suggesting that it acts on an upstream signalling pathway (s)."
22476871
reach
"The deubiquitinating activity of USP19 prevents protein degradation and increases the abundance of both PAH protein variants."
35987969
reach
"Conclusions : Loss of USP19 suppresses proteolysis upon glucocorticoid stimulation, but enhances protein synthesis upon fasting."
| PMC
reach
"We found that ectopic expression of USP19 increased PAH protein level, whereas depletion of USP19 promoted PAH protein degradation."
35449354
USP19 affects pathogenic potential Th17 cells
| 4
USP19 inhibits pathogenic potential Th17 cells. 4 / 4
| 4
eidos
"Collectively , our findings indicate that the USP19 selectively suppresses the pathogenic potential of Th17 cells , and provides novel strategies for treating autoimmune diseases ."
34135062
eidos
"Collectively , our findings indicate that USP19 selectively suppresses the pathogenic potential of Th17 cells and offer novel strategies for treating autoimmune diseases ."
34135062
eidos
"In line with our in vitro findings , these in vivo observations indicate that USP19 suppresses pathogenic potential of Th17 cells , and therefore ameliorates autoimmunity ."
34135062
eidos
"Collectively , our findings indicate that the USP19 selectively suppresses the pathogenic potential of Th17 cells and suggest strategies for treating autoimmune diseases ."
34135062
USP19 affects autophagy
| 4
USP19 activates autophagy.
| 3
USP19 activates autophagy. 3 / 3
| 3
reach
"USP19 positively regulates autophagy by stabilizing Beclin-1, an essential autophagy protein, via deubiquitination [27]."
| PMC
reach
"Consistent with this finding, a study has shown that the deubiquitinase USP19 stabilizes Beclin-1 by removing the K11-linked ubiquitin chains from Beclin-1, and positively regulates autophagy ."
30931944
reach
"By removing K11 linked chains at K437 from Beclin-1, an essential factor of autophagic initiation, USP19 induces autophagy and inhibits the production of type I IFN [XREF_BIBR]."
33402098
USP19 inhibits autophagy.
| 1
USP19 inhibits autophagy. 1 / 1
| 1
reach
"USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species."
33097834
USP19 affects TRIM69
| 4
USP19 inhibits TRIM69.
| 2
USP19 inhibits TRIM69. 1 / 1
| 1
reach
"These results suggest that USP19 impairs the association of TRIF with TLR3 after TLR3 activation in a deubiquitinating enzymatic activity dependent manner.Similarly, we found that overexpression of USP19 but not USP19(C607S) inhibited the association between TRIF and TLR4 (Fig. 6d)."
31511519
USP19-C607S inhibits TRIM69. 1 / 1
| 1
reach
"Further experiments indicated that wild-type USP19 but not USP19(C607S) impaired the interaction of TRIF with TLR3 or TLR4/TRAM, whereas USP19-deficiency increased the interactions."
31511519
USP19 deubiquitinates TRIM69.
| 1
USP19 leads to the deubiquitination of TRIM69. 1 / 1
| 1
reach
"In this study, we have identified the first deubiquitinating enzyme, USP19, which mediates deubiquitination of TRIF and regulates TRIF-mediated innate immune responses.Several lines of evidence support a key role of USP19 in TRIF-mediated signaling."
31511519
USP19 activates TRIM69.
| 1
USP19 activates TRIM69. 1 / 1
| 1
reach
"However, USP13, USP19, and USP22 inhibit virus-induced IFN production by removing K27-linked polyubiquitin chains from STING (40, 81) or TRIF (90)."
34707613
USP19 affects SNCA
1 | 3
USP19 activates SNCA.
| 3
USP19 activates SNCA. 3 / 3
| 3
reach
"Recently, the DUB, USP19, was shown to promote misfolded alpha-synuclein secretion [XREF_BIBR]."
28408429
reach
"However, under this condition, wild type (WT) USP19 is able to promote the secretion of misfolded alpha-Synuclein (alpha-Syn) in a dose dependent manner, as demonstrated previously 3."
29531792
reach
"Although USP19 stimulates alpha-synuclein secretion, exosome dependent tau secretion is not enhanced.113 4 Alternative Spreading Mechanisms."
30133080
USP19 increases the amount of SNCA.
1 |
USP19 increases the amount of SNCA. 1 / 1
1 |
bel
"USP19 promoted the secretion of a-syn, suggesting that MAPS is an unconventional secretion pathway utilized by a-syn, particularly under conditions of proteasomal impairment, which has been repeatedly linked to Parkinson’s disease. "
28803412
USP19 affects RAR
| 2 2
USP19 inhibits RAR.
| 2
USP19 inhibits RAR. 2 / 2
| 2
reach
"USP19 and CORO2A mediate the transcriptional repression of RAR."
27129179
reach
"RAR target genes were decreased by the overexpression of CORO2A, and increased by the knockdown of USP19 (XREF_SUPPLEMENTARY)."
27129179
USP19 binds RAR.
| 2
RAR binds USP19 and CORO2A. 2 / 2
| 2
sparser
"The results suggest that USP19 may be associated with the transcriptional regulation of RAR via CORO2A as one of the components for the NCoR complex during the adipogenesis."
27129179
sparser
"These results indicate that USP19 is associated with the regulation of transcriptional repression of RAR through CORO2A."
27129179
USP19 affects Mice
| 4
USP19 inhibits Mice.
| 2
USP19 inhibits Mice. 2 / 2
| 2
reach
"Gene knockout studies demonstrate that USP19 negatively regulates TLR3/4-mediated innate immune and inflammatory responses in cells and mice."
31511519
reach
"These data suggest that USP19 attenuates TLR3/4-mediated inflammatory responses in mice."
31511519
USP19 activates Mice.
| 2
USP19 activates Mice. 2 / 2
| 2
reach
"18 Genetic depletion of USP19 reduced Ewing sarcoma cell growth in vitro and in mice largely through destabilizing EWS–FLI1 proteins."
34060252
reach
"Loss of either SOAT1 or USP19 dramatically attenuates cholesterol esterification and hepatocarcinogenesis in the p53-deficient mice fed with either normal chow diet (NCD) or high-cholesterol, high-fat diet (HCHFD)."
35398929
USP19 affects MAP3K7
| 2 2
USP19 binds MAP3K7.
| 2
USP19 binds MAP3K7. 2 / 2
| 2
sparser
"Recently, our group found that USP19 is associated with TAK1 in a TNFα- or IL-1β-dependent manner and specifically deconjugates K63- and K27-linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of TAK1-TAB2/3 complex."
33469458
sparser
"Mechanistically, USP19 interacted with TAK1 in a TNF-α- or IL-1β-dependent manner and specifically deconjugated K63- and K27-linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of the TAK1-TAB2/3 complex."
31127032
USP19 ubiquitinates MAP3K7.
| 1
USP19 leads to the ubiquitination of MAP3K7. 1 / 1
| 1
reach
"USP19 Inhibits TNF-alpha- and IL-1beta-Triggered NF-kappaB Activation by Deubiquitinating TAK1."
31127032
USP19 deubiquitinates MAP3K7.
| 1
USP19 deubiquitinates MAP3K7. 1 / 1
| 1
reach
"These observations suggest that USP18 and USP19 deubiquitinate TAK1 in a cell type specific dependent manner."
33469458
USP19 affects FKBP6
4 |
USP19 binds FKBP6. 4 / 4
4 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
biogrid
No evidence text available
26186194
USP19 affects DNAJC5
| 3 1
USP19 binds DNAJC5.
| 1 1
USP19 binds DNAJC5. 2 / 2
| 1 1
sparser
"Because HSC70 forms a stable complex with its co-chaperone DNAJC5, which was recently implicated in unconventional secretion of Tau and α-Syn xref , we also tested whether USP19 could interact with DNAJC5."
29531792
reach
"Because HSC70 forms a stable complex with its co-chaperone DNAJC5, which was recently implicated in unconventional secretion of Tau and alpha-Syn 15, we also tested whether USP19 could interact with DNAJC5."
29531792
USP19 inhibits DNAJC5.
| 1
USP19 inhibits DNAJC5. 1 / 1
| 1
reach
"If so, depletion of USP19 should abolish DNAJC5 stimulated secretion."
29531792
USP19 activates DNAJC5.
| 1
USP19-C506S activates DNAJC5. 1 / 1
| 1
reach
"Moreover, we found that WT USP19 but not USP19 C506S also enhanced DNAJC5 secretion, consistent with the idea that when USP19 induced MAPS, DNAJC5 accompanied substrates to the cell exterior."
29531792
USP19 affects DDIT3
| 4
USP19 increases the amount of DDIT3.
| 3
USP19 increases the amount of DDIT3. 3 / 3
| 3
reach
"The higher levels of CHOP mRNA seen during regeneration in the USP19 KO muscle suggest that USP19 modulates transcription of CHOP, but modulation of CHOP mRNA stability can not be excluded."
25568336
reach
"First, USP19 (XREF_FIG) modulated the expression of CHOP, which had previously been shown to be the key marker of the ER stress response that occurs in only a small fraction of the differentiating myoblasts but is critical for differentiation."
25568336
reach
"The mechanisms by which CHOP expression is modulated by USP19 will require further study."
25568336
USP19 activates DDIT3.
| 1
USP19 activates DDIT3. 1 / 1
| 1
reach
"We therefore tested whether USP19 modulates this differentiation dependent CHOP induction and, if so, whether it requires ER localization."
25568336
FKBP6 affects USP19
4 |
USP19 binds FKBP6. 4 / 4
4 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
biogrid
No evidence text available
26186194
DNAJC5 affects USP19
| 3 1
DNAJC5 binds USP19.
| 1 1
USP19 binds DNAJC5. 2 / 2
| 1 1
sparser
"Because HSC70 forms a stable complex with its co-chaperone DNAJC5, which was recently implicated in unconventional secretion of Tau and α-Syn xref , we also tested whether USP19 could interact with DNAJC5."
29531792
reach
"Because HSC70 forms a stable complex with its co-chaperone DNAJC5, which was recently implicated in unconventional secretion of Tau and alpha-Syn 15, we also tested whether USP19 could interact with DNAJC5."
29531792
DNAJC5 increases the amount of USP19.
| 1
DNAJC5 increases the amount of USP19. 1 / 1
| 1
reach
"Although DNAJC5 knockdown reduced the expression of USP19 by ~ 30%, this was unlikely to account for the difference in MAPS efficiency between control and DNAJC5 knockdown cells for the following reasons."
29531792
DNAJC5 activates USP19.
| 1
DNAJC5 activates USP19. 1 / 1
| 1
reach
"Overexpression of DNAJC5 promotes MAPS independently of USP19."
29531792
Estrogen affects USP19
| 1 2
Estrogen increases the amount of USP19.
| 1
Estrogen increases the amount of USP19. 1 / 1
| 1
reach
"Collectively, the work by Ogawa and co-workers provides evidence that estrogen increases the expression of USP19 and contributes to muscle atrophy."
30930293
Estrogen decreases the amount of USP19.
| 1
Estrogen decreases the amount of USP19. 1 / 1
| 1
reach
"In support of this, estrogen acting via the ERalpha receptor can suppress differentiation and increase expression of USP19 in cultured muscle cells (Ogawa et al., 2011)."
23680672
Estrogen activates USP19.
| 1
Estrogen activates USP19. 1 / 1
| 1
eidos
"Collectively , the work by Ogawa and co-workers provides evidence that estrogen increases the expression of USP19 and contributes to muscle atrophy ."
30930293
Dexamethasone affects USP19
| 3
Dexamethasone activates USP19. 3 / 3
| 3
reach
"It is also possible that the deubiquitinating enzyme USP19, which is induced in atrophying skeletal muscle and stimulated by dexamethasone played a role in mediating the negative balance between muscle protein synthesis and proteolysis."
19952868
reach
"Dexamethasone or TNF-alpha treatment lowered MHC and increased USP19."
22477519
reach
"Dexamethasone treatment lowered MHC and increased USP19."
19773579
Daidzein affects USP19
| 3
Daidzein decreases the amount of USP19. 3 / 3
| 3
reach
"Dietary daidzein down-regulated the expression of USP19 at the mRNA and protein levels and increased soleus muscle mass in female mice, but not in males."
28886438
reach
"These results demonstrate that dietary daidzein decreases USP19 mRNA expression through ERbeta and increases soleus muscle mass in young female mice, but not in male mice, under physiological conditions."
28886438
reach
"Daidzein stimulated the transcriptional activity of ERbeta in murine C2C12 cells and down-regulated USP19 expression."
28886438
Ubiquitin affects USP19
| 3
sparser
"For instance, the full activation of USP19 requires its interaction with Hsp90, which promotes the binding of ubiquitin to the catalytic domain of USP19 [ xref ]."
30126257
sparser
"For instance, the full activation of USP19 requires its interaction with Hsp90, which promotes the binding of ubiquitin to the catalytic domain of USP19 [173]."
30126257
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
USP19 affects pTh17
| 3
USP19 inhibits pTh17. 3 / 3
| 3
reach
"Consistent with this finding, the deubiquitinase USP19 was shown to suppress pTh17 differentiation in vitro and Th17-mediated pathogenesis in vivo."
34135062
reach
"Consistent with these findings, the deubiquitinase USP19 suppressed pTh17 differentiation in vitro as well as Th17-mediated pathogenesis in vivo."
34135062
reach
"Consistent with these findings, a deubiquitinase USP19 suppressed pTh17 differentiation in vitro as well as Th17-mediated pathogenesis in murine autoimmune models."
34135062
USP19 affects myofibrillar proteins
| 3
USP19 increases the amount of myofibrillar proteins.
| 2
USP19 increases the amount of myofibrillar proteins. 2 / 2
| 2
reach
"Only the ER localized isoform of USP19 (USP19-ER) modulated myoblast fusion as well as the expression of myogenin and myofibrillar proteins, and these effects were also dependent on USP19 catalytic activity."
25568336
reach
"The USP19 deubiquitinating enzyme modulates the expression of myogenin and myofibrillar proteins in L6 muscle cells."
25568336
USP19 decreases the amount of myofibrillar proteins.
| 1
USP19 decreases the amount of myofibrillar proteins. 1 / 1
| 1
reach
"Evidence for a functional role arises from studies in myotubes which demonstrate that silencing of USP19 can increase expression of myofibrillar proteins (Sundaram et al., 2009)."
23680672
USP19 inhibits lipopolysaccharide. 3 / 3
| 3
reach
"USP19 deficiency increases the production of type I interferons (IFN) and proinflammatory cytokines induced by poly(I:C) or LPS in vitro and in vivo."
31511519
reach
"In similar assays, USP19 also inhibited LPS-induced signaling in 293-TLR4 cells (Supplementary Fig. 1b)."
31511519
reach
"Deficiency of USP19 increased serum cytokine levels after administration of poly(I:C) and LPS, and promoted inflammatory death caused by administration of poly(I:C) or LPS, or infection of Salmonella typhimurium."
31511519
USP19 affects cell growth
| 3
USP19 activates cell growth. 3 / 3
| 3
reach
"The results showed that knockdown of USP19 suppressed cell proliferation in SGC7901 cells while overexpressing USP19 accelerated cell growth in GES1 cells, as determined by MTT assay (P < 0.01, XREF_FIG and XREF_FIG)."
32904569
reach
"18 Genetic depletion of USP19 reduced Ewing sarcoma cell growth in vitro and in mice largely through destabilizing EWS–FLI1 proteins."
34060252
reach
"Therefore, the USP19 modulation of prostate cancer cell growth occurs through a regulation of cell cycle progression from G0/G1 to S phase and does not affect the rate of apoptotic cell death."
21264218
USP19 affects apoptotic process
| 1 1
sparser
"It has been also reported that USP19 inhibits TNFα -induced apoptosis via the stabilization of c-IAP s, which are ubiquitin ligases that regulate the stability of a variety of apoptotic and non-apoptotic proteins [ xref ]."
30716094
reach
"Among the additional 26 genes, we noted that module 28 included USP19 and LRRFIP2, which can inhibit apoptosis or pyroptosis and were higher in HIV-DNA cells, and TLN1 , which is required for antigen-driven T cell proliferation mediated through immunological synapses and was also higher in HIV-DNA cells."
36599978
USP19 affects TLR3/4
| 3
USP19 inhibits TLR3/4. 3 / 3
| 3
reach
"These data suggest that USP19 attenuates TLR3/4-mediated inflammatory responses in mice."
31511519
reach
"Collectively, these results suggest that USP19 negatively regulates TLR3/4-mediated induction of downstream effector genes in primary mouse immune cells or fibroblasts."
31511519
reach
"USP19 negatively regulates TLR3/4-mediated signaling."
31511519
USP19 affects TCRalpha
| 3
USP19 activates TCRalpha.
| 2
USP19 activates TCRalpha. 1 / 1
| 1
reach
"A catalytically inactive USP19 was still able to partly rescue TCRalpha but not CFTRDeltaF508, suggesting that USP19 might also exert a non catalytic function on specific ERAD substrates."
19465887
Mutated USP19 activates TCRalpha. 1 / 1
| 1
reach
"Interestingly, expression of a catalytically inactive USP19 mutant partially rescued TCRalpha, suggesting a DUB independent role during ERAD."
28159894
USP19 increases the amount of TCRalpha.
| 1
Modified USP19 increases the amount of TCRalpha. 1 / 1
| 1
reach
"Usp19 expression increases the levels of TCRalpha and mutant CFTR (cystic fibrosis transconductance regulator) consistent with its role in ERAD regulation."
21331300
USP19 affects SLC6A4
| 3
USP19 activates SLC6A4. 3 / 3
| 3
reach
"The major finding of this work is that cytoplasmic USP19 can promote aggregation of the polyQ expanded Atx3 and Htt proteins by up-regulating their protein levels."
26808260
reach
"Based on these lines of evidence, we propose a model for triage decision of the Htt protein modulated by USP19 through HSP90."
29093475
reach
"Our previous study has demonstrated that cytoplasmic ubiquitin specific protease 19 (USP19), through interacting with HSP90, up-regulates the protein levels of the N-terminal 552-residue fragments of Htt (Htt-N552) with normal and expanded polyQ, and consequently increases the aggregates formed by polyQ expanded Htt-N552 31."
29093475
USP19 affects RORC
| 3
RORC binds USP19. 3 / 3
| 3
sparser
"Although our results clearly demonstrate that USP19 interacts directly with RORγt and constrains pathogenic Th17 cell programming and response amplification, deubiquitinases also have effects on multiple other substrates."
34135062
sparser
"The interaction between USP19 and RORγt in pTh17 cells was validated by co-immunoprecipitation (co-IP) ( xref )."
34135062
sparser
"To test this possibility, we first examined whether USP19 would bind with RORγt under pTh17 polarizing conditions."
34135062
USP19 affects NLRP3
| 3
USP19 inhibits NLRP3.
| 2
USP19 inhibits NLRP3. 2 / 2
| 2
reach
"USP19 suppresses inflammation and promotes M2 like macrophage polarization by manipulating NLRP3 function via autophagy."
33097834
reach
"USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species."
33097834
USP19 activates NLRP3.
| 1
USP19 activates NLRP3. 1 / 1
| 1
reach
"In addition, USP19 inhibited the proteasomal degradation of inflammasome independent NLRP3 by cleaving its polyubiquitin chains."
33097834
USP19 affects GC
| 3
USP19 activates GC. 3 / 3
| 3
reach
"USP19 Promoted GC Cell Proliferation and Metastasis."
32904569
reach
"Our results showed that USP19 positively regulated GC cell migration through the up-regulation of MMP2 and MMP9 expression and the decrease of cleaved caspase-3 activity in cell models (XREF_FIG and XREF_FIG)."
32904569
reach
"Enhanced USP19 expression promoted GC cell proliferation and metastasis through reduced cleaved caspase-3 and increased MMP2 and MMP9 expression and promoted enzyme activity in the study, and verified the results through The Cancer Genome Atlas (TCGA) and bioinformatic websites from the Kaplan-Meier plotter (http://kmplot.com) and GEPIA (http://gepia2.cancer-pku.cn.)"
32904569
RORC affects USP19
| 3
RORC binds USP19. 3 / 3
| 3
sparser
"Although our results clearly demonstrate that USP19 interacts directly with RORγt and constrains pathogenic Th17 cell programming and response amplification, deubiquitinases also have effects on multiple other substrates."
34135062
sparser
"The interaction between USP19 and RORγt in pTh17 cells was validated by co-immunoprecipitation (co-IP) ( xref )."
34135062
sparser
"To test this possibility, we first examined whether USP19 would bind with RORγt under pTh17 polarizing conditions."
34135062
ESR1 affects USP19
| 3
ESR1 increases the amount of USP19.
| 2
ESR1 increases the amount of USP19. 2 / 2
| 2
reach
"These results demonstrate that (i) E2 induces USP19 expression through nuclear ERalpha, (ii) increased USP19 mediated deubiquitinating activity represses myogenesis, and (iii) ERbeta inhibits ERalpha activated USP19 expression."
21971047
reach
"A mutant form of ERalpha that is constitutively localized in the nucleus increased USP19 expression and decreased MHC and tropomyosin expression in the presence of E2."
21971047
ESR1 decreases the amount of USP19.
| 1
ESR1 decreases the amount of USP19. 1 / 1
| 1
reach
"Knockdown of ERalpha in hindlimb muscles decreased Usp19 mRNA expression and increased the mass of soleus muscle only in females."
25901042
BIRC2 affects USP19
1 | 1
USP19 binds BIRC2. 2 / 3
1 | 1
biogrid
No evidence text available
21849505
reach
"Here we report that USP19, a deubiquitinating enzyme, interacts with cellular IAP 1 (c-IAP1) and c-IAP2."
21849505
Trif affects USP19
| 2
USP19 binds trif. 2 / 2
| 2
sparser
"USP19 interacts with TRIF and removes the K27‐linked polyubiquitin moieties of TRIF, which inhibits the recruitment of TRIF to TLR3/4."
33511009
sparser
"Mechanistically, USP19 interacts with TRIF and catalyzes the removal of TRIF K27-linked polyubiquitin moieties, thereby impairing the recruitment of TRIF to TLR3/4."
31511519
XIAP affects USP19
2 |
USP19 binds XIAP. 2 / 2
2 |
biogrid
No evidence text available
21849505
biogrid
No evidence text available
21849505
VCP affects USP19
| 1 1
USP19 binds VCP. 2 / 2
| 1 1
reach
"In addition, it is also unclear whether or not USP19 can interact with p97."
22812527
sparser
"In addition, it is also unclear whether or not USP19 can interact with p97."
22812527
USP19 affects virus-induced IFN-I
| 2
USP19 inhibits virus-induced IFN-I. 2 / 2
| 2
eidos
"USP19 suppresses virus-induced IFN-I production by targeting TIR domain-containing adaptor inducing interferonb ( TRIF , also known as Ticam1 ) , which is an adaptor required for innate immune responses mediated by TLR3 and TLR4 ( 90 ) ."
34707613
eidos
"USP19 suppresses virus-induced IFN-I production by targeting TIR domain-containing adaptor inducing interferon-beta ( TRIF , also known as Ticam1 ) , which is an adaptor required for innate immune responses mediated by TLR3 and TLR4 ( 90 ) ."
34707613
USP19 affects ubiquitin proteasome
| 2
USP19 activates ubiquitin proteasome. 2 / 2
| 2
reach
"USP19 suppresses protein synthesis and enhances protein degradation (ubiquitin proteasome system and autophagy) suggesting that it acts on an upstream signalling pathway (s)."
22476871
reach
"In addition, we can not exclude that p27 Kip1 is also targeted by a non ubiquitin proteasome dependent or independent proteolytic mechanism whose activity is promoted by USP19."
21264218
USP19 affects trif
| 2
USP19 binds trif. 2 / 2
| 2
sparser
"USP19 interacts with TRIF and removes the K27‐linked polyubiquitin moieties of TRIF, which inhibits the recruitment of TRIF to TLR3/4."
33511009
sparser
"Mechanistically, USP19 interacts with TRIF and catalyzes the removal of TRIF K27-linked polyubiquitin moieties, thereby impairing the recruitment of TRIF to TLR3/4."
31511519
USP19 inhibits transcription, DNA-templated. 1 / 1
| 1
sparser
"Overexpression of USP19 inhibited RARE transcription and knock-down of USP19 using siRNA showed dramatically increased transcription of RARE (Figure xref and Figure xref ), suggesting that USP19 increases the stability of CORO2A by DUB activity, and that binding of these two protein may be associated with the function of NCoR."
27129179
USP19 activates transcription, DNA-templated. 1 / 1
| 1
reach
"100 Loss of USP19 increases transcription of myofibrillar proteins in L6 muscle cells and decreases muscle wasting in response to denervation in mice Priyanka Sundaram 1, Zhiyu Pang 2, Miao Miao 1, Nathalie Bedard 2, Tamara Moore 2, Patricia L. Hallauer 3, Kenneth E. Hastings 3, Simon S. Wing 2 1 Department of Biochemistry, McGill University, Montreal, QC, Canada; 2 Department of Medicine, McGill University, Montreal, QC, Canada; 3 Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada Background and aims : Although many enzymes involved in ubiquitination are activated in atrophying muscle, little is known about the role of deubiquitinating enzymes (DUBs)."
22477519
USP19 affects response
| 2
USP19 inhibits response. 2 / 2
| 2
eidos
"The results have shown that USP19 can inhibit the UPR response and weaken CHOP induction , thereby inhibiting muscle cell differentiation ( Figure 2r ) ."
33546413
eidos
"Although our results clearly demonstrate that USP19 interacts directly with RORgammat and constrains pathogenic Th17 cell programming and response amplification , deubiquitinases also have effects on multiple other substrates ."
34135062
USP19 affects receptor-alpha
| 2
USP19 activates receptor-alpha. 2 / 2
| 2
reach
"USP19 rescues the ERAD substrates cystic fibrosis transmembrane conductance regulator (CFTR) DeltaF508 and T-cell receptor-alpha (TCRalpha) from proteasomal degradation."
19465887
reach
"In preceding studies the ER localised USP19 was shown to rescue the ERAD substrates cystic fibrosis transmembrane conductance regulator (CFTR) DeltaF508 and T-cell receptor-alpha (TCRalpha) from proteasomal degradation 109."
28064438
reach
"USP19 suppresses inflammation and promotes M2 like macrophage polarization by manipulating NLRP3 function via autophagy."
33097834
eidos
"USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy ."
33097834
USP19 affects fusion protein
| 2
USP19 activates fusion protein. 2 / 2
| 2
eidos
"Depletion of USP19 decreased the fusion protein and increased EWS-FLI1 ubiquitination ."
30700749
eidos
"Most likely , USP19 , and other DUBs , modulate fusion protein levels to maintain Ewing sarcoma cell viability ."
30700749
USP19 inhibits endoplasmic reticulum. 1 / 1
| 1
reach
"Under these conditions, cell viability was unaffected and ER stress was not induced by USP19 knockdown."
27827840
USP19 deubiquitinates endoplasmic reticulum.
| 1
USP19 deubiquitinates endoplasmic reticulum. 1 / 1
| 1
reach
"In contrast, our studies have clearly demonstrated that USP19 catalytic activity is essential for its effects on differentiation and argue that USP19 is deubiquitinating an ER localized protein that represses the ER stress response."
25568336
reach
"Finally, these observations demonstrate that USP19 promotes the biogenesis of LRP6, with only 18% of newly synthesized LRP6 molecules surviving beyond 6 hr in the absence of USP19 and 60% surviving upon USP19 overexpression."
27751231
reach
"USP19 promotes LRP6 biogenesis and controls Wnt signaling."
27751231
USP19 affects cell migration
| 2
USP19 activates cell migration. 2 / 2
| 2
reach
"Our results showed that USP19 positively regulated GC cell migration through the up-regulation of MMP2 and MMP9 expression and the decrease of cleaved caspase-3 activity in cell models (XREF_FIG and XREF_FIG)."
32904569
reach
"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer."
33714979
USP19 affects XIAP
2 |
USP19 binds XIAP. 2 / 2
2 |
biogrid
No evidence text available
21849505
biogrid
No evidence text available
21849505
USP19 affects VCP
| 1 1
USP19 binds VCP. 2 / 2
| 1 1
reach
"In addition, it is also unclear whether or not USP19 can interact with p97."
22812527
sparser
"In addition, it is also unclear whether or not USP19 can interact with p97."
22812527
USP19 affects UBC
2 |
UBC binds USP19. 2 / 2
2 |
biogrid
No evidence text available
24356957
biogrid
No evidence text available
28190767
USP19 affects Th17
| 2
USP19 inhibits Th17. 2 / 2
| 2
reach
"Strikingly, silencing USP19 has a marginal impact on npTh17 differentiation, measured by the generation of IL-17A-producing cells (Fig. 3F), indicating USP19 selectively suppresses Th17 proinflammatory potential."
34135062
reach
"USP19 suppresses Th17-driven pathogenesis in autoimmunity."
34135062
USP19 affects TRAF3
1 | 1
USP19 deubiquitinates TRAF3.
1 |
USP19 deubiquitinates TRAF3. 1 / 1
1 |
ubibrowser
"USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination"
28391724
USP19 activates TRAF3.
| 1
USP19 activates TRAF3. 1 / 1
| 1
reach
"USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination."
28391724
USP19 affects SIAH
| 2
USP19 binds SIAH. 2 / 2
| 2
reach
"Phylogenetic analysis revealed the SIAH and USP19 complex is conserved in evolution."
27776223
reach
"(1) Constitutive binding partners, often as part of larger macromolecular complexes, e.g., USP22/SAGA-DUBm [167] and CSN5/COP9 signalosome [168] ; (2) low-affinity, transient binding partners, e.g., the USP19/SIAH complex [169] and USP8/NRDP1 [170] , or protein modifiers such as kinases, e.g., USP10/AMPKα [171] ; and (3) ubiquitinated substrates that bind DUBs by virtue of the Ub modification."
35625630
USP19 affects RPAP3
2 |
USP19 binds RPAP3. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
USP19 affects ROR
| 2
USP19 deubiquitinates ROR. 2 / 2
| 2
reach
"USP19 decreases the ubiquitination level on RORγt-K313, but not that on RORγt-K69 or K446 (Fig. 5C)."
34135062
reach
"Therefore, lysine residue 313 could be the major acting site of USP19 to prevent RORγt ubiquitination."
34135062
USP19 affects PFKFB3
| 2
USP19 ubiquitinates PFKFB3.
| 1
USP19 leads to the ubiquitination of PFKFB3. 1 / 1
| 1
reach
"By interacting with GPER, 17β-estradiol (E2) and the GPER agonist G1 enhance endothelial stability of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and capillary tube formation by increasing ubiquitin specific peptidase 19 (USP19) levels, thereby reducing PFKFB3 ubiquitination and proteasomal degradation."
37391222
USP19 deubiquitinates PFKFB3.
| 1
USP19 leads to the deubiquitination of PFKFB3. 1 / 1
| 1
reach
"By interacting with GPER, 17β-estradiol (E2) and the GPER agonist G1 enhance endothelial stability of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and capillary tube formation by increasing ubiquitin specific peptidase 19 (USP19) levels, thereby reducing PFKFB3 ubiquitination and proteasomal degradation."
37391222
USP19 affects Neoplasms
| 2
USP19 activates Neoplasms. 2 / 2
| 2
reach
"Moreover, the downregulation of USP19 promoted tumor growth in a xenograft model."
| PMC
reach
"Additionally, USP19 depletion results in significant enrichment of apoptosis and reduces the growth of tumors in the mouse xenograft."
35918893
USP19 affects NRF1
| 2
USP19 binds NRF1.
| 1
USP19 binds NRF1. 1 / 1
| 1
sparser
"Further experiments revealed that USP19 directly interacts with Nrf1 in proximity to the ER and topologically acts as a deubiquitinating enzyme to remove ubiquitin moieties from this protein, which allow it to circumvent potential proteasomal degradation."
35613680
USP19 activates NRF1.
| 1
USP19 activates NRF1. 1 / 1
| 1
sparser
"Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum."
35613680
USP19 affects NR3C1
1 | 1
USP19 increases the amount of NR3C1.
| 1
USP19 increases the amount of NR3C1. 1 / 1
| 1
reach
"Thus, USP19 modulates GR levels and in so doing may modulate both insulin and glucocorticoid signaling, two critical pathways that control protein turnover in muscle and overall glucose homeostasis."
29901692
USP19 deubiquitinates NR3C1.
1 |
USP19 deubiquitinates NR3C1. 1 / 1
1 |
ubibrowser
"Thus, USP19 modulates GR levels and in so doing may modulate both insulin and glucocorticoid signaling, two critical pathways that control protein turnover in muscle and overall glucose homeostasis."
29901692
USP19 affects NFE2L1
| 2
USP19 activates NFE2L1. 2 / 2
| 2
reach
"Conversely, knockout of USP19 causes significant decreases in the abundance of Nrf1 and the entrance of its active isoform into the nucleus, which result in the downregulation of its target proteasomal subunits and a modest reduction in USP19 -/- -derived tumor growth in xenograft mice when compared with wild-type controls."
35613680
reach
"Herein, we found that Nrf1 stability and transactivity are both enhanced by USP19, a ubiquitin-specific protease tail-anchored in the endoplasmic reticulum (ER) through its C-terminal transmembrane domain."
35613680
USP19 affects NADSYN1
| 2
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
USP19 binds HSPH1, DNAAF2, and NADSYN1. 1 / 1
| 1
sparser
"In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl‐G with dcTPR proteins."
30410862
USP19 affects MAPT
| 2
USP19 inhibits MAPT.
| 1
USP19 inhibits MAPT. 1 / 1
| 1
reach
"The results confirmed that DNAJC5 stimulated Tau secretion was not reduced by depletion of USP19."
29531792
USP19 activates MAPT.
| 1
USP19 activates MAPT. 1 / 1
| 1
reach
"USP19 CT incrementUI also stimulated GFP1-10 and Tau secretion."
29531792
USP19 affects K63-
| 2
USP19 binds K63-.
| 1
USP19 binds K27 and K63-. 1 / 1
| 1
reach
"Mechanistically, USP19 interacted with TAK1 in a TNF-alpha- or IL-1beta-dependent manner and specifically deconjugated K63- and K27 linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of the TAK1 and TAB2/3 complex."
31127032
USP19 activates K63-.
| 1
USP19 activates K63-. 1 / 1
| 1
reach
"E3 ligase ubiquitin-specific protease 19 (USP19) induces deconjugation of K63- and K27-linked polyubiquitin chains from TAK1, resulting in disruption of the TAK1-TAB2/3 complex (Leiet al., 2019)."
34414698
USP19 affects K63
| 2
USP19 binds HDAC1/2 and K63. 1 / 1
| 1
reach
"Importantly, we found that USP19 binds to HDAC1/2 and specifically regulating their K63 linked ubiquitination, which might be crucial for regulation of HDAC1/2 activity in DNA damage repair."
27517492
USP19 binds K63 and RORgammat-SRC3. 1 / 1
| 1
reach
"USP19 breaks RORgammat-SRC3 interaction through the removal K63-linked polyubiquitin moieties from RORgammat.."
34135062
USP19 affects K27
| 2
USP19 binds TICAM1 and K27. 1 / 1
| 1
reach
"USP19 interacts with TRIF and removes the K27 linked polyubiquitin moieties of TRIF, which inhibits the recruitment of TRIF to TLR3/4."
33511009
USP19 binds K27 and K63-. 1 / 1
| 1
reach
"Mechanistically, USP19 interacted with TAK1 in a TNF-alpha- or IL-1beta-dependent manner and specifically deconjugated K63- and K27 linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of the TAK1 and TAB2/3 complex."
31127032
USP19 affects ISRE
| 2
USP19 inhibits ISRE. 2 / 2
| 2
reach
"Reporter assays indicated that USP19 inhibited ISRE activation mediated by overexpression of TRIF but not TBK1 or IRF3 (Fig. 4a)."
31511519
reach
"As shown in Fig. 8a, USP19 markedly inhibited ISRE activation mediated by wild-type and all of the tested mutants of TRIF, with the exception of TRIF(K523R)."
31511519
USP19 affects HTT
| 2
USP19 activates HTT. 2 / 2
| 2
reach
"Cytoplasmic Ubiquitin Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone."
26808260
reach
"A mechanism of auto-inhibition of USP19 and activation by HSP90 is proposed, on which USP19 modulates the protein level of polyQ expanded huntingtin in cells."
33094816
USP19 affects GFP1-10
| 2
USP19 inhibits GFP1-10.
| 1
USP19 inhibits GFP1-10. 1 / 1
| 1
reach
"Since depletion of USP19 reduced the interaction of GFP1-10 with HSC70, USP19 seems to promote substrate binding by HSC70."
29531792
USP19 activates GFP1-10.
| 1
USP19 activates GFP1-10. 1 / 1
| 1
reach
"USP19 CT incrementUI also stimulated GFP1-10 and Tau secretion."
29531792
USP19 affects FKBPL
2 |
USP19 binds FKBPL. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
USP19 affects FKBP4
2 |
USP19 binds FKBP4. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
USP19 affects EWS-FLI1
| 1 1
USP19 deubiquitinates EWS-FLI1.
| 1
USP19 deubiquitinates EWS-FLI1. 1 / 1
| 1
reach
"USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth."
30700749
USP19 activates EWS-FLI1.
| 1
USP19 activates EWS-FLI1. 1 / 1
| 1
eidos
"Even though USP19 specifically modulated EWS-FLI1 but not EWSR1 protein levels ( Fig. 2e ) , we were still interested if USP19 possibly alters EWSR1 monoubiquitination levels35 ."
30700749
USP19 affects EWS-FLI1 protein
| 2
USP19 activates EWS-FLI1 protein. 2 / 2
| 2
eidos
"USP19 specifically modulates EWS-FLI1 protein levels ."
30700749
eidos
"Depletion of USP19 resulted in diminished EWS-FLI1 protein levels and , vice versa , upregulation of active USP19 stabilized the fusion protein ."
30700749
USP19 affects DOCK7
1 |
USP19 binds DOCK7. 1 / 2
1 |
biogrid
No evidence text available
19615732
USP19 affects DNAAF2
| 2
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
USP19 binds HSPH1, DNAAF2, and NADSYN1. 1 / 1
| 1
sparser
"In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl‐G with dcTPR proteins."
30410862
USP19 affects CDC37L1
2 |
USP19 binds CDC37L1. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
USP19 affects CDC37
2 |
USP19 binds CDC37. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
USP19 affects CD2BP2
2 |
USP19 binds CD2BP2. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
USP19 affects AURKC
2 |
AURKC binds USP19. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
UBC affects USP19
2 |
UBC binds USP19. 2 / 2
2 |
biogrid
No evidence text available
24356957
biogrid
No evidence text available
28190767
TBK1 affects USP19
| 2
TBK1 binds USP19 and HSPA8. 2 / 2
| 2
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression ."
34966378
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression (Zhao et al., 2021)."
34966378
SIAH affects USP19
| 2
USP19 binds SIAH. 2 / 2
| 2
reach
"Phylogenetic analysis revealed the SIAH and USP19 complex is conserved in evolution."
27776223
reach
"(1) Constitutive binding partners, often as part of larger macromolecular complexes, e.g., USP22/SAGA-DUBm [167] and CSN5/COP9 signalosome [168] ; (2) low-affinity, transient binding partners, e.g., the USP19/SIAH complex [169] and USP8/NRDP1 [170] , or protein modifiers such as kinases, e.g., USP10/AMPKα [171] ; and (3) ubiquitinated substrates that bind DUBs by virtue of the Ub modification."
35625630
RPAP3 affects USP19
2 |
USP19 binds RPAP3. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
RAR affects USP19
| 2
RAR binds USP19 and CORO2A. 2 / 2
| 2
sparser
"The results suggest that USP19 may be associated with the transcriptional regulation of RAR via CORO2A as one of the components for the NCoR complex during the adipogenesis."
27129179
sparser
"These results indicate that USP19 is associated with the regulation of transcriptional repression of RAR through CORO2A."
27129179
NADSYN1 affects USP19
| 2
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
USP19 binds HSPH1, DNAAF2, and NADSYN1. 1 / 1
| 1
sparser
"In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl‐G with dcTPR proteins."
30410862
MAP3K7 affects USP19
| 2
USP19 binds MAP3K7. 2 / 2
| 2
sparser
"Recently, our group found that USP19 is associated with TAK1 in a TNFα- or IL-1β-dependent manner and specifically deconjugates K63- and K27-linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of TAK1-TAB2/3 complex."
33469458
sparser
"Mechanistically, USP19 interacted with TAK1 in a TNF-α- or IL-1β-dependent manner and specifically deconjugated K63- and K27-linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of the TAK1-TAB2/3 complex."
31127032
LRP6 affects USP19
| 1 1
USP19 binds LRP6. 2 / 2
| 1 1
reach
"Consequently, our results indicate that the functional interaction between USP19 and LRP6 is key for the regulatory effect that USP19 exerts on the modulation of breast cancer cell migration and invasion."
33714979
sparser
"Consequently, our results indicate that the functional interaction between USP19 and LRP6 is key for the regulatory effect that USP19 exerts on the modulation of breast cancer cell migration and invasion."
33714979
K63 affects USP19
| 2
USP19 binds HDAC1/2 and K63. 1 / 1
| 1
reach
"Importantly, we found that USP19 binds to HDAC1/2 and specifically regulating their K63 linked ubiquitination, which might be crucial for regulation of HDAC1/2 activity in DNA damage repair."
27517492
USP19 binds K63 and RORgammat-SRC3. 1 / 1
| 1
reach
"USP19 breaks RORgammat-SRC3 interaction through the removal K63-linked polyubiquitin moieties from RORgammat.."
34135062
K27 affects USP19
| 2
USP19 binds TICAM1 and K27. 1 / 1
| 1
reach
"USP19 interacts with TRIF and removes the K27 linked polyubiquitin moieties of TRIF, which inhibits the recruitment of TRIF to TLR3/4."
33511009
USP19 binds K27 and K63-. 1 / 1
| 1
reach
"Mechanistically, USP19 interacted with TAK1 in a TNF-alpha- or IL-1beta-dependent manner and specifically deconjugated K63- and K27 linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of the TAK1 and TAB2/3 complex."
31127032
HSPA8 affects TBK1, and USP19
| 2
TBK1 binds USP19 and HSPA8. 2 / 2
| 2
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression ."
34966378
sparser
"USP19 interact with TBK1, HSPA8 as well as LAMP2A, promoting the expression of HSPA8 and LAMP2A. Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression (Zhao et al., 2021)."
34966378
HSPA8 LAMP2A affects USP19
| 2
HSPA8 LAMP2A activates USP19. 2 / 2
| 2
eidos
"Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression ."
34966378
eidos
"Knockdown of HSPA8 or LAMP2A disrupts CMA could restore the TBK1 protein level in the case of USP19 expression ( Zhao et al ., 2021 ) ."
34966378
HDAC2 affects HDAC1
| 2
USP19 binds HDAC1 and HDAC2. 2 / 2
| 2
sparser
"Immunoblot analysis showed that both HDAC1 and HDAC2 could bind to USP19 (Figure xref and xref )."
27517492
sparser
"USP19 interacts with HDAC1 and HDAC2."
27517492
FKBPL affects USP19
2 |
USP19 binds FKBPL. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
FKBP4 affects USP19
2 |
USP19 binds FKBP4. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
EV71 affects USP19
| 2
EV71 activates USP19. 2 / 2
| 2
reach
"Furthermore, EV71 infection induces the upregulation of USP19 which negatively regulates cellular antiviral type I interferon signaling by targeting the tumor necrosis receptor associated factor 3 (TRAF3) molecule and decreasing TRAF3 ubiquitination of K63-linkage [18]."
32674313
reach
"Previous studies have indicated that EV71 infection induces the up-regulation of USP19, which negatively regulates the antiviral type I interferon signalling by removing K-63 polyubiquitin chains from TRAF3 35."
30194441
DOCK7 affects USP19
1 |
USP19 binds DOCK7. 1 / 2
1 |
biogrid
No evidence text available
19615732
DNAAF2 affects USP19
| 2
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
USP19 binds HSPH1, DNAAF2, and NADSYN1. 1 / 1
| 1
sparser
"In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl‐G with dcTPR proteins."
30410862
CORO2A affects RAR, and USP19
| 2
RAR binds USP19 and CORO2A. 2 / 2
| 2
sparser
"The results suggest that USP19 may be associated with the transcriptional regulation of RAR via CORO2A as one of the components for the NCoR complex during the adipogenesis."
27129179
sparser
"These results indicate that USP19 is associated with the regulation of transcriptional repression of RAR through CORO2A."
27129179
CDC37L1 affects USP19
2 |
USP19 binds CDC37L1. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
CDC37 affects USP19
2 |
USP19 binds CDC37. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
CD2BP2 affects USP19
2 |
USP19 binds CD2BP2. 2 / 2
2 |
biogrid
No evidence text available
25036637
biogrid
No evidence text available
25036637
BECN1 affects USP19
| 2
BECN1 binds USP19. 2 / 2
| 2
sparser
"The Beclin 1-ubiquitin-specific protease 19 (BECN1–USP19) axis, a positive regulator of autophagy initiation and progression, plays a role in the crosstalk between autophagy and retinoic acid-inducible gene I (RIG-I) -mediated type I interferon signaling [ xref ]."
31941042
sparser
"Therefore, the BECN1-USP19 axis is important in the crosstalk between autophagy and antiviral immune responses [ xref ]."
31001336
AURKC affects USP19
2 |
AURKC binds USP19. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
reach
"They further showed that some DUBs that have been exposed to ROS can have different responses to reduction through DTT treatment, with some being activated by DTT (e.g., USP8, USP10, and USP19), some having only enhancement of activity in the presence of DTT (e.g., USP7, CYLD, and UCHL5), and others exhibiting no activity, despite the presence of a reducing agent (e.g., USP1, USP22, and A20) (35)."
34391779
reach
"Purified USP19CD behaved similarly to full-length USP19 as it contained little activity unless treated with DTT (XREF_SUPPLEMENTARY)."
23463011
Vinclozolin affects USP19
1 |
Vinclozolin decreases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
23034163
Tungsten affects USP19
1 |
Tungsten decreases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
30912803
Sunitinib affects USP19
1 |
Sunitinib decreases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
31533062
Specific shRNAs T cells affects USP19
| 1
Specific shRNAs T cells inhibits USP19. 1 / 1
| 1
eidos
"The general importance of the USP19 as a checkpoint for the pathogenic programming of Th17 cells is underscored by worsened EAE observed when USP19 is diminished by specific shRNAs in T cells ."
34135062
Sodium arsenite affects USP19
1 |
Sodium arsenite increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
16014739
SiUSP19s affects USP19
| 1
SiUSP19s inhibits USP19. 1 / 1
| 1
eidos
"Then , we depleted USP19 by siUSP19s and investigated the levels of endogenous as well as exogenous wild type or mutant EWS-FLI1 by western blotting ."
30700749
Phlorizin affects USP19
1 |
Phlorizin increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
22538082
Paracetamol affects USP19
1 |
Paracetamol increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
22230336
Methyl methanesulfonate increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
26011545
Melatonin affects USP19
1 |
Melatonin increases the amount of USP19. 1 / 1
1 |
bel
"Table 2. Genes showing melatonin-induced upregulation in peripheral blood mononuclear cell"
16635017
reach
"These results suggest that overexpression of USP19 inhibits poly(I:C)- and LPS-triggered IRF3 and NF-κB activation.We next examined the role of endogenous USP19 in regulation of TLR3/4-mediated signaling."
31511519
Inducible shUSP19 constructs affects USP19
| 1
Inducible shUSP19 constructs inhibits USP19. 1 / 1
| 1
eidos
"To this end , we established SKNMC and A673 cells stably expressing two inducible shUSP19 constructs which allow to deplete USP19 by addition of doxycycline ."
30700749
Hsa-miR-615-3p affects USP19
1 |
Hsa-miR-615-3p decreases the amount of USP19. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-196a-5p affects USP19
1 |
Hsa-miR-196a-5p decreases the amount of USP19. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-186-5p affects USP19
1 |
Hsa-miR-186-5p decreases the amount of USP19. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-183-5p affects USP19
1 |
Hsa-miR-183-5p decreases the amount of USP19. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hexabromocyclododecane increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
29177809
Furan affects USP19
1 |
Furan methylates USP19. 1 / 1
1 |
ctd
No evidence text available
22079235
Estradiol affects USP19
| 1
Estradiol increases the amount of USP19. 1 / 1
| 1
reach
"It is shown that estradiol can induce expression of USP19 and with the above mentioned mechanism can repress myotube formation XREF_BIBR."
30775480
Enzyme inhibitor affects USP19
1 |
Enzyme inhibitor inhibits USP19. 1 / 1
1 |
ctd
No evidence text available
23301498
Entrance active isoform nucleus affects USP19
| 1
Entrance active isoform nucleus activates USP19. 1 / 1
| 1
eidos
"Conversely , knockout of USP19 causes significant decreases in the abundance of Nrf1 and the entrance of its active isoform into the nucleus , which result in the downregulation of its target proteasomal subunits and a modest reduction in USP19 - / - - derived tumor growth in xenograft mice when compared with wild-type controls ."
35613680
Doxycycline affects USP19
| 1
Doxycycline inhibits USP19. 1 / 1
| 1
eidos
"To this end , we established SKNMC and A673 cells stably expressing two inducible shUSP19 constructs which allow to deplete USP19 by addition of doxycycline ."
30700749
Copper atom affects USP19
1 |
Copper atom increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
30556269
Cadmium dichloride demethylates USP19. 1 / 1
1 |
ctd
No evidence text available
22457795
Beta-carotene affects USP19
| 1
Beta-carotene decreases the amount of USP19. 1 / 1
| 1
reach
"In the denervated soleus muscle, beta-carotene administration significantly decreased the expression levels of Atrogin-1, MuRF1, USP14 and USP19 (P < 0.05, n 5) and the levels of ubiquitin conjugates."
23046823
Atrazine affects USP19
1 |
Atrazine increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
22378314
Aflatoxin B1 affects USP19
1 |
Aflatoxin B1 increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
19770486
Acrylamide affects USP19
1 |
Acrylamide increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
30807115
Abundance affects USP19
| 1
Abundance activates USP19. 1 / 1
| 1
eidos
"Conversely , knockout of USP19 causes significant decreases in the abundance of Nrf1 and the entrance of its active isoform into the nucleus , which result in the downregulation of its target proteasomal subunits and a modest reduction in USP19 - / - - derived tumor growth in xenograft mice when compared with wild-type controls ."
35613680
YP_009227204 affects USP19
1 |
USP19 binds YP_009227204. 1 / 1
1 |
virhostnet
No evidence text available
30037810
XRN2 affects USP19
1 |
USP19 binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
22939629
Ubiquitin affects FLI1
| 1
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
USP7 affects USP19
1 |
USP19 binds USP7. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP4 affects USP19
1 |
USP19 binds USP4. 1 / 1
1 |
biogrid
No evidence text available
22706160
USP19
| 1
USP19 translocates to the nucleus. 1 / 1
| 1
sparser
"In this study, we found that deubiquitination enzymes USP19 translocate into nucleus upon DNA damage treatment and physically interacts with HDAC1/2 for regulating the K63-linked ubiquitination of HDAC1/2."
27517492
USP19 affects virus-induced
| 1
USP19 inhibits virus-induced. 1 / 1
| 1
eidos
"However , USP13 , USP19 , and USP22 inhibit virus-induced IFN production by removing K27-linked polyubiquitin chains from STING ( 40 , 81 ) or TRIF ( 90 ) ."
34707613
USP19 affects vice active USP19 stabilized fusion protein
| 1
USP19 activates vice active USP19 stabilized fusion protein. 1 / 1
| 1
eidos
"Depletion of USP19 resulted in diminished EWS-FLI1 protein levels and , vice versa , upregulation of active USP19 stabilized the fusion protein ."
30700749
USP19 affects unrelated non-tumorigenic cell lines
| 1
USP19 activates unrelated non-tumorigenic cell lines. 1 / 1
| 1
eidos
"( h , i ) USP19 depletion has limited effect in unrelated non-tumorigenic cell lines ."
30700749
USP19 affects ubiquitination RORgammat-K313 RORgammat-K69 K446
| 1
USP19 inhibits ubiquitination RORgammat-K313 RORgammat-K69 K446. 1 / 1
| 1
eidos
"USP19 decreases the ubiquitination level on RORgammat-K313 , but not that on RORgammat-K69 or K446 ( Fig. 5C ) ."
34135062
USP19 affects tumorigenicity
| 1
USP19 activates tumorigenicity. 1 / 1
| 1
eidos
"( A ) Downregulation of USP19 attenuates tumorigenicity in vivo : Control or USP19-silenced MDAMB231 cells were subcutaneously inoculated into the mammary fat pads of female NOD / SCID mice and tumor growth monitored every 2-3 days ."
33714979
USP19 affects tumor foci
| 1
USP19 activates tumor foci. 1 / 1
| 1
eidos
"As shown in Fig. 5B , USP19 depletion inhibits tumor foci formation in vivo , as evaluated by human DNA quantification ( left ) and metastatic load quantification in Hematoxylin & Eosin-stained lung sections ( right , and Supp ."
33714979
USP19 affects tumor cell invasion
| 1
USP19 activates tumor cell invasion. 1 / 1
| 1
eidos
"Collectively , our results indicate that USP19 knockdown inhibits tumor cell invasion in vitro ."
33714979
USP19 activates translational termination. 1 / 1
| 1
reach
"Gene sequencing results showed that a thymidine was inserted into the third exon of Usp19 gene, which caused a reading-frame shift and the early translational termination of Usp19 after aa 42 ."
31511519
USP19 affects transactivity
| 1
USP19 activates transactivity. 1 / 1
| 1
eidos
"Herein , we found that Nrf1 stability and transactivity are both enhanced by USP19 , a ubiquitin-specific protease tail-anchored in the endoplasmic reticulum ( ER ) through its C-terminal transmembrane domain ."
35613680
USP19 affects suggesting have oncogenic properties33
| 1
USP19 activates suggesting have oncogenic properties33. 1 / 1
| 1
eidos
"There , USP19 depletion inhibited proliferation of prostate cancer and breast epithelial cell lines suggesting it to have oncogenic properties33 ,34 ."
30700749
USP19 affects stability MARCHF6
| 1
USP19 activates stability MARCHF6. 1 / 1
| 1
eidos
"Interestingly , USP19 , an ER-resident DUB , and cholesterol enhance the stability of MARCHF6 [ 250,251 ] ."
33669844
reach
"Furthermore, USP19 deficiency in macrophages caused an elevation of TBK1 and the activation of the type-I interferon signaling pathway after vesicular stomatitis virus (VSV) infection."
34436957
USP19 affects several mitotic defects including cytokinesis
| 1
USP19 activates several mitotic defects including cytokinesis. 1 / 1
| 1
eidos
"Targeted genome knockout verified that USP19 depletion leads to several mitotic defects , including cytokinesis failure ."
35918893
USP19 affects self-ubiquitin ligase
| 1
USP19 inhibits self-ubiquitin ligase. 1 / 1
| 1
reach
"These results suggest that the self-ubiquitin ligase activity of c-IAPs is inhibited by USP19 and implicate deubiquitinating enzymes in the regulation of IAP stability."
21849505
USP19 affects recruitment TLR3
| 1
USP19 inhibits recruitment TLR3. 1 / 1
| 1
eidos
"USP19 interacts with TIR domain-containing adaptor inducing interferon-beta ( TRIF ) , and thus impairs its recruitment to TLR3 / 4 [ 61 ] ."
32650621
USP19 affects pyroptosis
| 1
USP19 inhibits pyroptosis. 1 / 1
| 1
reach
"Among the additional 26 genes, we noted that module 28 included USP19 and LRRFIP2, which can inhibit apoptosis or pyroptosis and were higher in HIV-DNA cells, and TLN1 , which is required for antigen-driven T cell proliferation mediated through immunological synapses and was also higher in HIV-DNA cells."
36599978
USP19 affects proteasomal inflammasome-independent NLRP3
| 1
USP19 inhibits proteasomal inflammasome-independent NLRP3. 1 / 1
| 1
eidos
"In addition , USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains ."
33097834
USP19 affects prostate cancer breast epithelial cell lines
| 1
USP19 activates prostate cancer breast epithelial cell lines. 1 / 1
| 1
eidos
"There , USP19 depletion inhibited proliferation of prostate cancer and breast epithelial cell lines suggesting it to have oncogenic properties33 ,34 ."
30700749
USP19 affects polyubiquitination PAH
| 1
USP19 inhibits polyubiquitination PAH. 1 / 1
| 1
eidos
"Our study indicates that USP19 interacts with PAH and prevents polyubiquitination of PAH subsequently extending the half-life of PAH protein ."
35449354
USP19 affects polyubiquitin chains
| 1
USP19 inhibits polyubiquitin chains. 1 / 1
| 1
reach
"In addition, USP19 inhibited the proteasomal degradation of inflammasome independent NLRP3 by cleaving its polyubiquitin chains."
33097834
USP19 affects pathogenic potential
| 1
USP19 inhibits pathogenic potential. 1 / 1
| 1
eidos
"Taken together , USP19 suppresses pTh17 differentiation and pathogenic potential through the removal of K63-linked ubiquitin chain from lysine 313 of RORgammat , which is required for recruiting coactivator SRC3 and essential for the expression of proinflammatory effectors ( Fig. 6E ) ."
34135062
USP19 affects pathogenic Th17 cell programming
| 1
USP19 inhibits pathogenic Th17 cell programming. 1 / 1
| 1
eidos
"Although our results clearly demonstrate that USP19 interacts directly with RORgammat and constrains pathogenic Th17 cell programming and response amplification , deubiquitinases also have effects on multiple other substrates ."
34135062
USP19 affects pTh17 differentiation
| 1
USP19 inhibits pTh17 differentiation. 1 / 1
| 1
eidos
"Taken together , USP19 suppresses pTh17 differentiation and pathogenic potential through the removal of K63-linked ubiquitin chain from lysine 313 of RORgammat , which is required for recruiting coactivator SRC3 and essential for the expression of proinflammatory effectors ( Fig. 6E ) ."
34135062
USP19 affects pTh17 cell differentiation
| 1
USP19 inhibits pTh17 cell differentiation. 1 / 1
| 1
eidos
"USP19 selectively suppresses pTh17 cell differentiation in vitro ."
34135062
USP19 affects migratory potential cells control cell line
| 1
USP19 activates migratory potential cells control cell line. 1 / 1
| 1
eidos
"As shown in Fig. 2D and E , USP19 knockdown significantly decreased the migratory potential of cells relative to the control cell line ."
33714979
USP19 affects membrane-bound Nrf1 transcription
| 1
USP19 activates membrane-bound Nrf1 transcription. 1 / 1
| 1
eidos
"Activation of the membrane-bound Nrf1 transcription factor by USP19 , a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum ."
35613680
USP19 affects localization
| 1
USP19 activates localization. 1 / 1
| 1
reach
"We therefore tested whether USP19 modulates this differentiation dependent CHOP induction and, if so, whether it requires ER localization."
25568336
USP19 affects lipogenesis colorectal carcinogenesis
| 1
USP19 activates lipogenesis colorectal carcinogenesis. 1 / 1
| 1
eidos
"USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1 ."
34965422
USP19 affects invading cells total displacement
| 1
USP19 activates invading cells total displacement. 1 / 1
| 1
eidos
"Our results show that USP19 knockdown significantly reduced the number of invading cells as well as their total displacement , compared to the control cell line ( Fig. 3A ) ."
33714979
USP19 affects hypoxia-induced mitochondrial division
| 1
USP19 activates hypoxia-induced mitochondrial division. 1 / 1
| 1
eidos
"USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites ."
33978709
USP19 affects hypertrophic
| 1
USP19 inhibits hypertrophic. 1 / 1
| 1
eidos
"Consistently , gain-of-function and loss-of-function approaches that involved USP19 in cardiomyocytes suggested that the down-regulation of USP19 promoted the hypertrophic phenotype , while the up-regulation of USP19 improved the worsened phenotype ."
32798288
USP19 affects growth tumors mouse xenograft
| 1
USP19 activates growth tumors mouse xenograft. 1 / 1
| 1
eidos
"Additionally , USP19 depletion results in significant enrichment of apoptosis and reduces the growth of tumors in the mouse xenograft ."
35918893
USP19 affects glucose
| 1
USP19 activates glucose. 1 / 1
| 1
reach
"The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice."
30386869
USP19 affects ges-1
| 1
USP19 activates ges-1. 1 / 1
| 1
reach
"Transwell assay showed that knockdown of USP19 decreased invasiveness of SGC7901 cells, whereas overexpression of USP19 enhanced GES1 cell invasion (P < 0.01; XREF_FIG and XREF_FIG, respectively)."
32904569
USP19 affects extending half-life PAH protein
| 1
USP19 inhibits extending half-life PAH protein. 1 / 1
| 1
eidos
"Our study indicates that USP19 interacts with PAH and prevents polyubiquitination of PAH subsequently extending the half-life of PAH protein ."
35449354
reach
"Moreover, USP19-ER inhibits TGF-β-induced epithelial-mesenchymal transition (EMT), whereas USP19-CY enhances EMT, as well as the migration and extravasation of breast cancer cells."
36646950
USP19 affects enzymatic PAH
| 1
USP19 activates enzymatic PAH. 1 / 1
| 1
eidos
"USP19 increases the enzymatic activity of PAH , thus maintaining normal Phe levels ."
35449354
USP19 affects dioxygen
| 1
USP19 activates dioxygen. 1 / 1
| 1
reach
"USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species."
33097834
USP19 affects dexamethasone
| 1
USP19 activates dexamethasone. 1 / 1
| 1
reach
"Depletion of USP19 reversed the dexamethasone suppression of MHC."
19773579
reach
"Moreover, mild thapsigargin-induced ER stress abolished suppression of the C2C12 cell fusion caused by the overexpression of the deubiquitinating enzyme USP19 [64]."
36180988
reach
"The chromosome segregation errors induced by USP19 knockdown was reversed by the expression of siRNA resistant wild-type USP19."
27517492
reach
"Loss of either SOAT1 or USP19 dramatically attenuates cholesterol esterification and hepatocarcinogenesis in the p53-deficient mice fed with either normal chow diet (NCD) or high-cholesterol, high-fat diet (HCHFD)."
35398929
USP19 affects characteristic trait tumor cells42
| 1
USP19 activates characteristic trait tumor cells42. 1 / 1
| 1
eidos
"USP19 knockdown impairs invasion Cell motility is often associated with increased tumor cell invasion and is a characteristic trait of aggressive tumor cells42 ,43 ."
33714979
USP19 affects cellular migration
| 1
USP19 activates cellular migration. 1 / 1
| 1
eidos
"Our in vitro validation experiments showed that USP19 depletion did not affect cell proliferation in agreement with Lu et al.64 , but directly inhibited cellular migration ."
33714979
USP19 affects cellular invasion
| 1
USP19 activates cellular invasion. 1 / 1
| 1
eidos
"USP19 knockdown reduces cellular invasion ."
33714979
USP19 affects cancer cell migration
| 1
USP19 activates cancer cell migration. 1 / 1
| 1
eidos
"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life ."
33714979
USP19 affects cIAP proteins
| 1
USP19 deubiquitinates cIAP proteins. 1 / 1
| 1
reach
"Previous studies in HEK293 cells have shown that USP19 can deubiquitinate and stabilize cIAP proteins (Mei et al., 2011)."
23680672
USP19 affects c-IAPs
| 1
USP19 decreases the amount of c-IAPs. 1 / 1
| 1
reach
"Knockdown of USP19 decreases levels of both c-IAPs, whereas overexpression of USP19 results in a marked increase in c-IAP levels."
21849505
USP19 affects c-IAP1/2
| 1
USP19 leads to the deubiquitination of c-IAP1/2. 1 / 1
| 1
reach
"USP19 is shown to prevent ubiquitination of c-IAP1/2 and stabilizes them."
29479529
USP19 affects alpha-Syn
| 1
USP19 activates alpha-Syn. 1 / 1
| 1
reach
"Under our experimental conditions, 50% reduction in USP19 expression did not significantly reduced alpha-Syn secretion."
29531792
USP19 affects a-syn
| 1
USP19 activates a-syn. 1 / 1
| 1
reach
"USP19 promoted the secretion of a-syn, suggesting that MAPS is an unconventional secretion pathway utilized by a-syn, particularly under conditions of proteasomal impairment, which has been repeatedly linked to Parkinson 's disease."
28803412
USP19 affects YP_009227204
1 |
USP19 binds YP_009227204. 1 / 1
1 |
virhostnet
No evidence text available
30037810
USP19 affects XRN2
1 |
USP19 binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP19 affects Ubiquitination
| 1
USP19 inhibits Ubiquitination. 1 / 1
| 1
eidos
"USP19 binds to the EWSR1 domain of the fusion protein , as demonstrated by co-immunoprecipitation experiments , and reduces ubiquitination at an acceptor lysine site ( the K380 residue35 ) in the FLI1 domain ."
30700749
USP19 affects USP7
1 |
USP19 binds USP7. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects USP4
1 |
USP19 binds USP4. 1 / 1
1 |
biogrid
No evidence text available
22706160
USP19 affects USP19
| 1
Modified USP19 decreases the amount of USP19. 1 / 1
| 1
reach
"Overexpression of USP19 inhibited RARE transcription and knock-down of USP19 using siRNA showed dramatically increased transcription of RARE, suggesting that USP19 increases the stability of CORO2A by DUB activity, and that binding of these two protein may be associated with the function of NCoR."
27129179
USP19 affects USP19 protein
| 1
USP19 activates USP19 protein. 1 / 1
| 1
eidos
"Similar to the initial screening , USP19 depletion resulted in reduction of USP19 protein levels and subsequent decrease of EWS-FLI1 protein by around 40 % after 72 h , in both A673 and SKNMC cells ( Fig. 2a , b ) ."
30700749
USP19 affects UPR
| 1
USP19 activates UPR. 1 / 1
| 1
reach
"We attempted to determine whether USP19 modulates specific UPR signaling pathways, but our analyses have been limited by the small percentage of cells that manifest UPR activation during differentiation."
25568336
USP19 affects UNC45A
1 |
USP19 binds UNC45A. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects UBL
| 1
USP19 binds SLAMF7 and UBL. 1 / 1
| 1
sparser
"We found that the tandem CS domains fold back to interact with the C-terminal USP domain (USPD) intra-molecularly that leads to inhibition of the catalytic core of USP19, especially CS1 interacts with the embedded UbL domain and CS2 does with the CH2 catalytic core."
33094816
USP19 affects Th17-mediated pathogenesis autoimmunity
| 1
USP19 inhibits Th17-mediated pathogenesis autoimmunity. 1 / 1
| 1
eidos
"Suppression of USP19 enhances Th17-mediated pathogenesis of autoimmunity ."
34135062
USP19 affects Th17-driven pathogenesis autoimmunity T helper
| 1
USP19 inhibits Th17-driven pathogenesis autoimmunity T helper. 1 / 1
| 1
eidos
"USP19 suppresses Th17-driven pathogenesis in autoimmunity T helper 17 ( Th17 ) cells have emerged as a chief pathogenic cell type in murine models of autoimmunity and human autoimmune diseases ."
34135062
USP19 affects Th17 proinflammatory potential
| 1
USP19 inhibits Th17 proinflammatory potential. 1 / 1
| 1
eidos
"Strikingly , silencing USP19 has a marginal impact on npTh17 differentiation , measured by the generation of IL-17A-producing cells ( Fig. 3F ) , indicating USP19 selectively suppresses Th17 proinflammatory potential ."
34135062
USP19 affects TRIM25
1 |
USP19 binds TRIM25. 1 / 1
1 |
biogrid
No evidence text available
29117863
USP19 affects TRIM21
1 |
TRIM21 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects TRA
1 |
TRA binds USP19. 1 / 1
1 |
biogrid
No evidence text available
19465887
USP19 affects TP53
| 1
USP19 activates TP53. 1 / 1
| 1
reach
"Loss of either SOAT1 or USP19 dramatically attenuates cholesterol esterification and hepatocarcinogenesis in the p53-deficient mice fed with either normal chow diet (NCD) or high-cholesterol, high-fat diet (HCHFD)."
35398929
USP19 affects TOP3B
| 1
TOP3B binds USP19. 1 / 1
| 1
sparser
"The HumanNet v2 functional network analysis further revealed that TOP3B and USP19 might physically interact ( xref D)."
| PMC
USP19 affects TNPO3
1 |
USP19 binds TNPO3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects TNF
| 1
USP19 inhibits TNF. 1 / 1
| 1
sparser
"Removal of K27- and K63-linked chains by USP19 inhibited TNFα- and IL-1β-induced NFκB activation, suggesting that these ubiquitin chains normally activate TAK1 downstream signaling ( xref )."
32039206
USP19 affects TMEM33
1 |
USP19 binds TMEM33. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects TLR3
| 1
USP19 inhibits TLR3. 1 / 1
| 1
reach
"These results suggest that USP19 impairs the association of TRIF with TLR3 after TLR3 activation in a deubiquitinating enzymatic activity dependent manner.Similarly, we found that overexpression of USP19 but not USP19(C607S) inhibited the association between TRIF and TLR4 (Fig. 6d)."
31511519
USP19 affects TLN1
1 |
TLN1 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP19 affects TICAM1
| 1
USP19 binds TICAM1 and K27. 1 / 1
| 1
reach
"USP19 interacts with TRIF and removes the K27 linked polyubiquitin moieties of TRIF, which inhibits the recruitment of TRIF to TLR3/4."
33511009
USP19 affects TGFB
| 1
USP19 activates TGFB. 1 / 1
| 1
reach
"Here, we demonstrated that USP19-CY promotes TGF-β signaling by directly interacting with TGF-β type I receptor (TβRI) and protecting it from degradation at the plasma membrane."
36646950
USP19 affects Sarcoma, Ewing
| 1
USP19 activates Sarcoma, Ewing. 1 / 1
| 1
reach
"18 Genetic depletion of USP19 reduced Ewing sarcoma cell growth in vitro and in mice largely through destabilizing EWS–FLI1 proteins."
34060252
USP19 affects SUCLG2
1 |
SUCLG2 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects STUB1
1 |
STUB1 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
26808260
USP19 affects SRPRB
1 |
USP19 binds SRPRB. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects SOAT1
| 1
USP19 deubiquitinates SOAT1. 1 / 1
| 1
reach
"USP19 enhances cholesterol esterification and contributes to hepatocarcinogenesis by deubiquitinating and stabilizing SOAT1."
35398929
USP19 affects SNRNP200
1 |
USP19 binds SNRNP200. 1 / 1
1 |
biogrid
No evidence text available
23500468
USP19 affects SLC1A5
1 |
SLC1A5 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects SLAMF7
| 1
USP19 binds SLAMF7 and UBL. 1 / 1
| 1
sparser
"We found that the tandem CS domains fold back to interact with the C-terminal USP domain (USPD) intra-molecularly that leads to inhibition of the catalytic core of USP19, especially CS1 interacts with the embedded UbL domain and CS2 does with the CH2 catalytic core."
33094816
USP19 affects SKP2
1 |
SKP2 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP19 affects SIAH ligases
| 1
USP19 binds SIAH ligases. 1 / 1
| 1
reach
"A specific interaction between the two SIAH ligases and endogenous USP19 was detected in immunoprecipitates performed with either the anti-HA or anti-FLAG antibodies."
23500468
USP19 affects SEL1L
1 |
SEL1L binds USP19. 1 / 1
1 |
biogrid
No evidence text available
24356957
USP19 affects SEC61A2
1 |
USP19 binds SEC61A2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects SEC61A1
1 |
USP19 binds SEC61A1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects SAAL1
1 |
USP19 binds SAAL1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects RORgammat-SRC3
| 1
USP19 binds K63 and RORgammat-SRC3. 1 / 1
| 1
reach
"USP19 breaks RORgammat-SRC3 interaction through the removal K63-linked polyubiquitin moieties from RORgammat.."
34135062
USP19 affects RNF2
1 |
RNF2 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
23500468
USP19 affects RARS1
| 1
USP19 activates RARS1. 1 / 1
| 1
reach
"Therefore, we hypothesized that USP19, which was found to bind with CORO2A, may mediate the function of the RARs via transcriptional repression of RARE."
27129179
USP19 affects Population
| 1
USP19 inhibits Population. 1 / 1
| 1
eidos
"In contrast , reducing USP19 notably fostered pTh17 differentiation ( Fig. 3C and Supplementary Fig. 2A ) , increasing IL-17A + IFN-gamma + population by approximately 2-fold ."
34135062
USP19 affects PYGL
1 |
USP19 binds PYGL. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects PDHA1
1 |
USP19 binds PDHA1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects PARK7
1 |
USP19 binds PARK7. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects PAH protein
| 1
USP19 activates PAH protein. 1 / 1
| 1
eidos
"We found that ectopic expression of USP19 increased PAH protein level , whereas depletion of USP19 promoted PAH protein degradation ."
35449354
USP19 affects Nrf1 stability
| 1
USP19 activates Nrf1 stability. 1 / 1
| 1
eidos
"Herein , we found that Nrf1 stability and transactivity are both enhanced by USP19 , a ubiquitin-specific protease tail-anchored in the endoplasmic reticulum ( ER ) through its C-terminal transmembrane domain ."
35613680
USP19 affects NUP160
1 |
USP19 binds NUP160. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects NTRK1
1 |
USP19 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
USP19 affects NS5A
| 1
USP19 binds NS5A. 1 / 1
| 1
sparser
"It was shown that the NS5A-USP19 interaction induces USP19 relocalization to HCV replication compartments, thus inhibiting cell proliferation and promoting viral persistence through perturbation of cell metabolism."
25809442
USP19 affects NP_751927
1 |
USP19 binds NP_751927. 1 / 1
1 |
virhostnet
No evidence text available
18985028
USP19 affects NLRP3 inflammasome
| 1
USP19 inhibits NLRP3 inflammasome. 1 / 1
| 1
eidos
"USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species ."
33097834
USP19 affects NFkappaB
| 1
USP19 activates NFkappaB. 1 / 1
| 1
reach
"So an attractive hypothesis is that USP19 might promote muscle atrophy by stabilizing cIAPs and activating the NFkappaB pathway."
23680672
USP19 affects NEURL4
1 |
USP19 binds NEURL4. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects MYH
| 1
USP19 inhibits MYH. 1 / 1
| 1
reach
"They found that a decrease of USP19 promoted muscle cell fusion and increased myotube diameter and expressions of myogenin and myosin heavy chain."
24595460
USP19 affects MYC
| 1
USP19 binds MYC. 1 / 1
| 1
sparser
"For this, we co-expressed myc-USP19 with 3xflag-EWS-FLI1 wild-type or mutants (K298R or K380R) and observed binding of USP19 to both EWS-FLI1 mutants, indicating that the interaction itself is independent of the presence of an ubiquitin chain (Fig.  xref )."
30700749
USP19 affects MLF2
1 |
USP19 binds MLF2. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP19 affects MGMT
1 |
USP19 binds MGMT. 1 / 1
1 |
biogrid
No evidence text available
16226712
USP19 affects ME1
| 1
USP19 binds ME1. 1 / 1
| 1
sparser
"Collectively, the USP19-ME1 axis plays a vital role in colorectal carcinogenesis and may also provide a potential therapeutic target."
34965422
USP19 affects MARCHF7
| 1
USP19 activates MARCHF7. 1 / 1
| 1
reach
"Furthermore, DUBs are known to regulate stability of only 4 of these proteins, including the ubiquitin ligases MARCH7 and BIRC3, which are targeted by USP7 or USP9 and USP19, respectively."
33417828
USP19 affects MARCHF6 [
| 1
USP19 activates MARCHF6 [. 1 / 1
| 1
reach
"Interestingly, USP19, an ER-resident DUB, and cholesterol enhance the stability of MARCHF6 [XREF_BIBR, XREF_BIBR]."
33669844
USP19 affects M2-like macrophage polarization
| 1
USP19 activates M2-like macrophage polarization. 1 / 1
| 1
eidos
"USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy ."
33097834
USP19 affects LRPPRC
1 |
USP19 binds LRPPRC. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects LAT
1 |
USP19 binds LAT. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects LAMTOR4
1 |
USP19 binds LAMTOR4. 1 / 1
1 |
biogrid
No evidence text available
23500468
USP19 affects KPTN
1 |
USP19 binds KPTN. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP19 affects Infections
| 1
USP19 inhibits Infections. 1 / 1
| 1
reach
"Deficiency of USP19 increased serum cytokine levels after administration of poly(I:C) and LPS, and promoted inflammatory death caused by administration of poly(I:C) or LPS, or infection of Salmonella typhimurium."
31511519
USP19 affects IRF3
1 |
USP19 binds IRF3. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP19 affects INS
| 1
USP19 activates INS. 1 / 1
| 1
reach
"Moreover, HFD fed Usp19 -/- mice had enhanced insulin signalling in the muscle and the liver, but not in adipose tissue."
30386869
USP19 affects IL17A
| 1
USP19 inhibits IL17A. 1 / 1
| 1
eidos
"In contrast , reducing USP19 notably fostered pTh17 differentiation ( Fig. 3C and Supplementary Fig. 2A ) , increasing IL-17A + IFN-gamma + population by approximately 2-fold ."
34135062
USP19 affects IFNG
| 1
USP19 inhibits IFNG. 1 / 1
| 1
eidos
"In contrast , reducing USP19 notably fostered pTh17 differentiation ( Fig. 3C and Supplementary Fig. 2A ) , increasing IL-17A + IFN-gamma + population by approximately 2-fold ."
34135062
USP19 affects IARS1
1 |
USP19 binds IARS1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects Hyperglycemia
| 1
USP19 activates Hyperglycemia. 1 / 1
| 1
reach
"USP22 in pancreatic β-cells, USP2 in adipose tissue macrophages, USP9X, 20, and 33 in myocytes, USP4, 7, 10, and 18 in hepatocytes, and USP2 in hypothalamus improve hyperglycemia, whereas USP19 in adipocytes, USP21 in myocytes, and USP2, 14, and 20 in hepatocytes promote hyperglycemia."
36834633
USP19 affects Htt-N90
| 1
USP19 activates Htt-N90. 1 / 1
| 1
reach
"Modulation of Htt-N90 by USP19 is dependent on the interaction with HSP90."
29093475
USP19 affects Htt-N552
| 1
USP19 activates Htt-N552. 1 / 1
| 1
reach
"We next examined the effect of usp19 silencing on the protein levels of Atx3 100Q and Htt-N552 100Q, and observed that knockdown of USP19 significantly reduced the protein levels of Atx3 100Q (XREF_FIG) and Htt-N552 100Q (XREF_FIG) both in HEK 293T cells and in human retinal pigment epithelial (RPE1) cells (XREF_SUPPLEMENTARY)."
26808260
USP19 affects Htt-N552 fragment
| 1
USP19 deubiquitinates Htt-N552 fragment. 1 / 1
| 1
reach
"Our previous study has demonstrated that cytoplasmic USP19 deubiquitinates the Htt-N552 fragment and consequently increases the protein level and aggregation, and this effect is dependent on the interaction of USP19 with HSP90 31."
29093475
USP19 affects HSPH1
| 1
USP19 binds HSPH1, DNAAF2, and NADSYN1. 1 / 1
| 1
sparser
"In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl‐G with dcTPR proteins."
30410862
USP19 affects HSPA4
1 |
USP19 binds HSPA4. 1 / 1
1 |
biogrid
No evidence text available
24356957
USP19 affects HNRNPAB
1 |
USP19 binds HNRNPAB. 1 / 1
1 |
biogrid
No evidence text available
23500468
USP19 affects HMOX2
1 |
USP19 binds HMOX2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects HERC2
1 |
USP19 binds HERC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects HDAC
| 1
HDAC binds USP19. 1 / 1
| 1
reach
"Interestingly, as shown in Figure XREF_FIG and Figure XREF_FIG, we found much stronger binding of USP19 to HDAC1 in response to IR irradiation, further suggesting the HDAC and USP19 complex was involved in DNA damage response."
27517492
USP19 affects HCVgp1
1 |
USP19 binds HCVgp1. 1 / 1
1 |
biogrid
No evidence text available
22810585
USP19 affects H9c2
| 1
USP19 activates H9c2. 1 / 1
| 1
reach
"The Role of USP19 in the C3G Mediated Protective Effect and Ferroptosis on OGD/R Induced H9c2 Cells."
33628391
USP19 inhibits Genomic Instability. 1 / 1
| 1
reach
"As to its essential role in DNA repair and in maintaining chromosome stability, USP19 might be critical for cells to prevent genome instability and its deletion might be contributed to tumorigenesis."
27517492
USP19 affects GCN1
1 |
USP19 binds GCN1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects FLVCR1
| 1
USP19 activates FLVCR1. 1 / 1
| 1
reach
"Reports indicate that the disruption of USP19 inhibits a series of PCa cell proliferation by arresting cells in the G1 to S phase transition through stabilization of the cyclin-dependent kinase inhibitor p27 ."
34660907
USP19 affects FLNA
1 |
USP19 binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
23500468
USP19 affects FKBP8
1 |
USP19 binds FKBP8. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects FKBP51
| 1
USP19 binds AIP and FKBP51. 1 / 1
| 1
sparser
"We confirmed interaction of ubiquitin carboxypeptidase Usp19 with two dcTPR proteins, AIP and FKBP51, via the dicarboxylate clamp mechanism."
30410862
USP19 affects FERD3L
1 |
USP19 binds FERD3L. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP19 affects FAF2
1 |
USP19 binds FAF2. 1 / 1
1 |
biogrid
No evidence text available
24356957
USP19 affects EWSR1-FLI1
| 1
USP19 activates EWSR1-FLI1. 1 / 1
| 1
eidos
"Depletion of USP19 was shown to decrease EWSR1-FLI1 expression levels , but neither the expression of wild-type of EWSR1 nor FLI1 , and to reduce tumor growth in vitro and in vivo indicating a potential therapeutic value for USP19 inhibition [ 101 ] ."
31970591
USP19 affects EWS-FLI1 ubiquitination
| 1
USP19 activates EWS-FLI1 ubiquitination. 1 / 1
| 1
eidos
"EWS-FLI1 ubiquitination is modulated by USP19 ."
30700749
USP19 affects ERAD machinery factors
| 1
USP19 binds ERAD machinery factors. 1 / 1
| 1
reach
"Intriguingly, although overexpressed USP19 interacts with Derlin-1 and other ERAD machinery factors in the membrane, endogenous USP19 is mostly in the cytosol where it binds Hsp90."
24356957
USP19 affects ECEL1
1 |
USP19 binds ECEL1. 1 / 1
1 |
biogrid
No evidence text available
23500468
USP19 affects E3_Ub_ligase
| 1
USP19 deubiquitinates E3_Ub_ligase. 1 / 1
| 1
reach
"USP19 deubiquitinates and stabilizes KPC1, an E3 ligase for p27."
34660907
USP19 affects Death
| 1
USP19 inhibits Death. 1 / 1
| 1
reach
"Deficiency of USP19 increased serum cytokine levels after administration of poly(I:C) and LPS, and promoted inflammatory death caused by administration of poly(I:C) or LPS, or infection of Salmonella typhimurium."
31511519
USP19 affects DOCK5
1 |
USP19 binds DOCK5. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP19 affects DNM1L
| 1
USP19 binds DNM1L. 1 / 1
| 1
sparser
"Interestingly, Chai et al. also found that USP19 could interact with DRP1, although the exact mechanism is still unknown, and whether USP19 promotes the oligomeric transfer of DRP1 to MERCSs requires further investigation ( xref )."
35281107
USP19 affects DNAJC7
1 |
DNAJC7 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP19 affects DMWD
1 |
USP19 binds DMWD. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects DDX58
| 1
USP19 activates DDX58. 1 / 1
| 1
reach
"For example, USP3, USP38, and USP19 target RIG-I, TBK1, and TRAF3 for deubiquitination, respectively, thereby blocking the activation of type I IFN signaling pathways."
30408499
USP19 affects CSE1L
1 |
USP19 binds CSE1L. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects CRYL1
1 |
USP19 binds CRYL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP19 affects CKAP5
1 |
USP19 binds CKAP5. 1 / 1
1 |
biogrid
No evidence text available
23500468
USP19 affects CFTRDeltaF508
| 1
USP19 activates CFTRDeltaF508. 1 / 1
| 1
reach
"A catalytically inactive USP19 was still able to partly rescue TCRalpha but not CFTRDeltaF508, suggesting that USP19 might also exert a non catalytic function on specific ERAD substrates."
19465887
USP19 affects CFTR ER-associated degradation
| 1
USP19 inhibits CFTR ER-associated degradation. 1 / 1
| 1
eidos
"CFTR ubiquitylation at the ER is reversible , and USP19 , an ER membrane tail-anchored de-ubiquitylating enzyme ( DUB ) , has been reported to suppress the CFTR ER-associated degradation ( ERAD ) [ 33 ] ."
32331485
USP19 affects CDKN2A
| 1
USP19 activates CDKN2A. 1 / 1
| 1
reach
"USP19 siRNA, but not control siRNA led to an accumulation of p27 Kip1, but not p16 or p21 as exemplified in the DU145 model (XREF_FIG)."
21264218
USP19 affects CDK1
1 |
USP19 binds CDK1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects CAMK2_complex
| 1
CAMK2_complex binds USP19. 1 / 1
| 1
reach
"Interestingly, Usp19 also interacts with CaMK-II and since alphakap forms complexes with CaMK-II, it is possible that alphakap may function as a scaffold for Usp19."
22496563
USP19 affects CAMK2G
1 |
USP19 binds CAMK2G. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects CACYBP
1 |
USP19 binds CACYBP. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP19 affects BIRC5
| 1
USP19 deubiquitinates BIRC5. 1 / 1
| 1
reach
"USP19 deubiquitinates survivin protein and extends its half-life."
35918893
USP19 affects BHLH
| 1
USP19 binds HIF1A and BHLH. 1 / 1
| 1
sparser
"This was based on findings showing that USP19 can interact with the bHLH-PAS domain of HIF-1α, but not HIF-2α, and with SIAH1 and SIAH2, which are known components of the hypoxia pathway since they regulate the presence of PHD 1/3 enzymes [ xref , xref ]."
31208103
USP19 affects Autoimmunity
| 1
USP19 activates Autoimmunity. 1 / 1
| 1
eidos
"In line with our in vitro findings , these in vivo observations indicate that USP19 suppresses pathogenic potential of Th17 cells , and therefore ameliorates autoimmunity ."
34135062
USP19 affects ATAD1
1 |
USP19 binds ATAD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects ACADSB
1 |
USP19 binds ACADSB. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP19 affects ABCB11
| 1
USP19 decreases the amount of mutated ABCB11. 1 / 1
| 1
reach
"In addition, USP19 knockdown leads to increased expression of mutant ABCB11, an ERAD substrate of MARCH6."
25088257
UNC45A affects USP19
1 |
USP19 binds UNC45A. 1 / 1
1 |
biogrid
No evidence text available
19615732
UBL affects USP19
| 1
USP19 binds SLAMF7 and UBL. 1 / 1
| 1
sparser
"We found that the tandem CS domains fold back to interact with the C-terminal USP domain (USPD) intra-molecularly that leads to inhibition of the catalytic core of USP19, especially CS1 interacts with the embedded UbL domain and CS2 does with the CH2 catalytic core."
33094816
TRIM25 affects USP19
1 |
USP19 binds TRIM25. 1 / 1
1 |
biogrid
No evidence text available
29117863
TRIM21 affects USP19
1 |
TRIM21 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
19615732
TRA affects USP19
1 |
TRA binds USP19. 1 / 1
1 |
biogrid
No evidence text available
19465887
TOP3B affects USP19
| 1
TOP3B binds USP19. 1 / 1
| 1
sparser
"The HumanNet v2 functional network analysis further revealed that TOP3B and USP19 might physically interact ( xref D)."
| PMC
TNPO3 affects USP19
1 |
USP19 binds TNPO3. 1 / 1
1 |
biogrid
No evidence text available
19615732
TNF affects USP19
| 1
TNF activates USP19. 1 / 1
| 1
reach
"Dexamethasone or TNF-alpha treatment lowered MHC and increased USP19."
22477519
TMEM33 affects USP19
1 |
USP19 binds TMEM33. 1 / 1
1 |
biogrid
No evidence text available
19615732
TLN1 affects USP19
1 |
TLN1 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
22939629
TICAM1 affects USP19
| 1
USP19 binds TICAM1 and K27. 1 / 1
| 1
reach
"USP19 interacts with TRIF and removes the K27 linked polyubiquitin moieties of TRIF, which inhibits the recruitment of TRIF to TLR3/4."
33511009
SUCLG2 affects USP19
1 |
SUCLG2 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
19615732
STUB1 affects USP19
1 |
STUB1 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
26808260
SRPRB affects USP19
1 |
USP19 binds SRPRB. 1 / 1
1 |
biogrid
No evidence text available
19615732
SNRNP200 affects USP19
1 |
USP19 binds SNRNP200. 1 / 1
1 |
biogrid
No evidence text available
23500468
SLC1A5 affects USP19
1 |
SLC1A5 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
19615732
SLAMF7 affects USP19
| 1
USP19 binds SLAMF7 and UBL. 1 / 1
| 1
sparser
"We found that the tandem CS domains fold back to interact with the C-terminal USP domain (USPD) intra-molecularly that leads to inhibition of the catalytic core of USP19, especially CS1 interacts with the embedded UbL domain and CS2 does with the CH2 catalytic core."
33094816
SKP2 affects USP19
1 |
SKP2 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
28514442
SIAH ligases affects USP19
| 1
USP19 binds SIAH ligases. 1 / 1
| 1
reach
"A specific interaction between the two SIAH ligases and endogenous USP19 was detected in immunoprecipitates performed with either the anti-HA or anti-FLAG antibodies."
23500468
SEL1L affects USP19
1 |
SEL1L binds USP19. 1 / 1
1 |
biogrid
No evidence text available
24356957
SEC61A2 affects USP19
1 |
USP19 binds SEC61A2. 1 / 1
1 |
biogrid
No evidence text available
19615732
SEC61A1 affects USP19
1 |
USP19 binds SEC61A1. 1 / 1
1 |
biogrid
No evidence text available
19615732
SAAL1 affects USP19
1 |
USP19 binds SAAL1. 1 / 1
1 |
biogrid
No evidence text available
19615732
Reperfusion Injury increases the amount of USP19. 1 / 1
| 1
reach
"As illustrated in Figures XREF_FIG and XREF_FIG, the I/R procedure remarkably increased the protein levels of USP19, Beclin1, NCOA4, and LC3II and LC3I."
33628391
RORgammat-SRC3 affects USP19
| 1
USP19 binds K63 and RORgammat-SRC3. 1 / 1
| 1
reach
"USP19 breaks RORgammat-SRC3 interaction through the removal K63-linked polyubiquitin moieties from RORgammat.."
34135062
RNF2 affects USP19
1 |
RNF2 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
23500468
PYGL affects USP19
1 |
USP19 binds PYGL. 1 / 1
1 |
biogrid
No evidence text available
19615732
PDHA1 affects USP19
1 |
USP19 binds PDHA1. 1 / 1
1 |
biogrid
No evidence text available
19615732
PARK7 affects USP19
1 |
USP19 binds PARK7. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAH affects USP19
| 1
USP19 binds PAH. 1 / 1
| 1
sparser
"Our study indicates that USP19 interacts with PAH and prevents polyubiquitination of PAH subsequently extending the half-life of PAH protein."
35449354
OGD/R model affects USP19
| 1
OGD/R model activates USP19. 1 / 1
| 1
reach
"As expected, the OGD/R model resulted in the upregulation of USP19, Beclin1, NCOA4, and LC3II and LC3I."
33628391
NUP160 affects USP19
1 |
USP19 binds NUP160. 1 / 1
1 |
biogrid
No evidence text available
19615732
NTRK1 affects USP19
1 |
USP19 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NS5A affects USP19
| 1
USP19 binds NS5A. 1 / 1
| 1
sparser
"It was shown that the NS5A-USP19 interaction induces USP19 relocalization to HCV replication compartments, thus inhibiting cell proliferation and promoting viral persistence through perturbation of cell metabolism."
25809442
NRF1 affects USP19
| 1
USP19 binds NRF1. 1 / 1
| 1
sparser
"Further experiments revealed that USP19 directly interacts with Nrf1 in proximity to the ER and topologically acts as a deubiquitinating enzyme to remove ubiquitin moieties from this protein, which allow it to circumvent potential proteasomal degradation."
35613680
NP_751927 affects USP19
1 |
USP19 binds NP_751927. 1 / 1
1 |
virhostnet
No evidence text available
18985028
NEURL4 affects USP19
1 |
USP19 binds NEURL4. 1 / 1
1 |
biogrid
No evidence text available
19615732
NADSYN1 affects HSPH1
| 1
USP19 binds HSPH1, DNAAF2, and NADSYN1. 1 / 1
| 1
sparser
"In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl‐G with dcTPR proteins."
30410862
NADSYN1 affects AIP
| 1
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
MYC affects USP19
| 1
USP19 binds MYC. 1 / 1
| 1
sparser
"For this, we co-expressed myc-USP19 with 3xflag-EWS-FLI1 wild-type or mutants (K298R or K380R) and observed binding of USP19 to both EWS-FLI1 mutants, indicating that the interaction itself is independent of the presence of an ubiquitin chain (Fig.  xref )."
30700749
MLF2 affects USP19
1 |
USP19 binds MLF2. 1 / 1
1 |
biogrid
No evidence text available
22863883
MGMT affects USP19
1 |
USP19 binds MGMT. 1 / 1
1 |
biogrid
No evidence text available
16226712
ME1 affects USP19
| 1
USP19 binds ME1. 1 / 1
| 1
sparser
"Collectively, the USP19-ME1 axis plays a vital role in colorectal carcinogenesis and may also provide a potential therapeutic target."
34965422
LRPPRC affects USP19
1 |
USP19 binds LRPPRC. 1 / 1
1 |
biogrid
No evidence text available
19615732
LAT affects USP19
1 |
USP19 binds LAT. 1 / 1
1 |
biogrid
No evidence text available
19615732
LAMTOR4 affects USP19
1 |
USP19 binds LAMTOR4. 1 / 1
1 |
biogrid
No evidence text available
23500468
KPTN affects USP19
1 |
USP19 binds KPTN. 1 / 1
1 |
biogrid
No evidence text available
26186194
K63- affects USP19
| 1
USP19 binds K27 and K63-. 1 / 1
| 1
reach
"Mechanistically, USP19 interacted with TAK1 in a TNF-alpha- or IL-1beta-dependent manner and specifically deconjugated K63- and K27 linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of the TAK1 and TAB2/3 complex."
31127032
K63 affects RORgammat-SRC3, and USP19
| 1
USP19 binds K63 and RORgammat-SRC3. 1 / 1
| 1
reach
"USP19 breaks RORgammat-SRC3 interaction through the removal K63-linked polyubiquitin moieties from RORgammat.."
34135062
K63 affects HDAC1/2
| 1
USP19 binds HDAC1/2 and K63. 1 / 1
| 1
reach
"Importantly, we found that USP19 binds to HDAC1/2 and specifically regulating their K63 linked ubiquitination, which might be crucial for regulation of HDAC1/2 activity in DNA damage repair."
27517492
K27 affects TICAM1, and USP19
| 1
USP19 binds TICAM1 and K27. 1 / 1
| 1
reach
"USP19 interacts with TRIF and removes the K27 linked polyubiquitin moieties of TRIF, which inhibits the recruitment of TRIF to TLR3/4."
33511009
K27 affects K63-, and USP19
| 1
USP19 binds K27 and K63-. 1 / 1
| 1
reach
"Mechanistically, USP19 interacted with TAK1 in a TNF-alpha- or IL-1beta-dependent manner and specifically deconjugated K63- and K27 linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of the TAK1 and TAB2/3 complex."
31127032
IRF3 affects USP19
1 |
USP19 binds IRF3. 1 / 1
1 |
biogrid
No evidence text available
28514442
IARS1 affects USP19
1 |
USP19 binds IARS1. 1 / 1
1 |
biogrid
No evidence text available
19615732
Htt-N90 affects USP19
| 1
Htt-N90 bound to HSP90 activates USP19. 1 / 1
| 1
reach
"Moreover, ubiquitin specific protease 19 (USP19), a deubiquitinating enzyme interacting with HSP90, up-regulates the protein level of Htt-N90 and consequently promotes its aggregation, whereas disruption of the interaction between Htt-N90 and HSP90 attenuates the effect of USP19 on Htt-N90."
29093475
HSPH1 affects USP19
| 1
USP19 binds HSPH1, DNAAF2, and NADSYN1. 1 / 1
| 1
sparser
"In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl‐G with dcTPR proteins."
30410862
HSPA4 affects USP19
1 |
USP19 binds HSPA4. 1 / 1
1 |
biogrid
No evidence text available
24356957
HNRNPAB affects USP19
1 |
USP19 binds HNRNPAB. 1 / 1
1 |
biogrid
No evidence text available
23500468
HMOX2 affects USP19
1 |
USP19 binds HMOX2. 1 / 1
1 |
biogrid
No evidence text available
19615732
HIF1A affects BHLH
| 1
USP19 binds HIF1A and BHLH. 1 / 1
| 1
sparser
"This was based on findings showing that USP19 can interact with the bHLH-PAS domain of HIF-1α, but not HIF-2α, and with SIAH1 and SIAH2, which are known components of the hypoxia pathway since they regulate the presence of PHD 1/3 enzymes [ xref , xref ]."
31208103
HERC2 affects USP19
1 |
USP19 binds HERC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
HDAC1/2 affects K63, and USP19
| 1
USP19 binds HDAC1/2 and K63. 1 / 1
| 1
reach
"Importantly, we found that USP19 binds to HDAC1/2 and specifically regulating their K63 linked ubiquitination, which might be crucial for regulation of HDAC1/2 activity in DNA damage repair."
27517492
HDAC affects USP19
| 1
HDAC binds USP19. 1 / 1
| 1
reach
"Interestingly, as shown in Figure XREF_FIG and Figure XREF_FIG, we found much stronger binding of USP19 to HDAC1 in response to IR irradiation, further suggesting the HDAC and USP19 complex was involved in DNA damage response."
27517492
HCVgp1 affects USP19
1 |
USP19 binds HCVgp1. 1 / 1
1 |
biogrid
No evidence text available
22810585
GCN1 affects USP19
1 |
USP19 binds GCN1. 1 / 1
1 |
biogrid
No evidence text available
19615732
GC affects USP19
| 1
GC activates USP19. 1 / 1
| 1
reach
"USP19 Promoted GC Cell Proliferation and Metastasis."
32904569
FLNA affects USP19
1 |
USP19 binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
23500468
FLI1 affects Ubiquitin
| 1
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
FKBP8 affects USP19
1 |
USP19 binds FKBP8. 1 / 1
1 |
biogrid
No evidence text available
19615732
FKBP51 affects USP19
| 1
USP19 binds AIP and FKBP51. 1 / 1
| 1
sparser
"We confirmed interaction of ubiquitin carboxypeptidase Usp19 with two dcTPR proteins, AIP and FKBP51, via the dicarboxylate clamp mechanism."
30410862
FERD3L affects USP19
1 |
USP19 binds FERD3L. 1 / 1
1 |
biogrid
No evidence text available
28514442
FAF2 affects USP19
1 |
USP19 binds FAF2. 1 / 1
1 |
biogrid
No evidence text available
24356957
EWSR1 affects Ubiquitin
| 1
Ubiquitin binds USP19, EWSR1, and FLI1. 1 / 1
| 1
sparser
"As the main ubiquitin acceptor site for EWS-FLI1 degradation is located in the FLI1 terminus xref , we were next interested in identifying whether USP19 still interacts with EWS-FLI1 ubiquitin acceptor site mutants."
30700749
EV71 infection affects USP19
| 1
EV71 infection activates USP19. 1 / 1
| 1
eidos
"Previous studies have illustrated that EV71 infection led to the upregulation of USP19 [ 18 ] and USP19 could stabilize Beclin1 by decreasing the K11-linked ubiquitin chains leading to the inhibition of Beclin1 degradation [ 42 ] , which may provide partial explanation of our results ."
32674313
ERAD machinery factors affects USP19
| 1
USP19 binds ERAD machinery factors. 1 / 1
| 1
reach
"Intriguingly, although overexpressed USP19 interacts with Derlin-1 and other ERAD machinery factors in the membrane, endogenous USP19 is mostly in the cytosol where it binds Hsp90."
24356957
ECEL1 affects USP19
1 |
USP19 binds ECEL1. 1 / 1
1 |
biogrid
No evidence text available
23500468
DOCK5 affects USP19
1 |
USP19 binds DOCK5. 1 / 1
1 |
biogrid
No evidence text available
28514442
DNM1L affects USP19
| 1
USP19 binds DNM1L. 1 / 1
| 1
sparser
"Interestingly, Chai et al. also found that USP19 could interact with DRP1, although the exact mechanism is still unknown, and whether USP19 promotes the oligomeric transfer of DRP1 to MERCSs requires further investigation ( xref )."
35281107
DNAJC7 affects USP19
1 |
DNAJC7 binds USP19. 1 / 1
1 |
biogrid
No evidence text available
28514442
DNAAF2 affects HSPH1, NADSYN1, and USP19
| 1
USP19 binds HSPH1, DNAAF2, and NADSYN1. 1 / 1
| 1
sparser
"In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl‐G with dcTPR proteins."
30410862
DNAAF2 affects AIP
| 1
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
DMWD affects USP19
1 |
USP19 binds DMWD. 1 / 1
1 |
biogrid
No evidence text available
19615732
DDX58 affects USP19
| 1
DDX58 activates USP19. 1 / 1
| 1
reach
"For example, USP3, USP38, and USP19 target RIG-I, TBK1, and TRAF3 for deubiquitination, respectively, thereby blocking the activation of type I IFN signaling pathways."
30408499
CSE1L affects USP19
1 |
USP19 binds CSE1L. 1 / 1
1 |
biogrid
No evidence text available
19615732
CRYL1 affects USP19
1 |
USP19 binds CRYL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
CKAP5 affects USP19
1 |
USP19 binds CKAP5. 1 / 1
1 |
biogrid
No evidence text available
23500468
CFTR affects USP19
1 |
USP19 binds CFTR. 1 / 1
1 |
biogrid
No evidence text available
19465887
CDK1 affects USP19
1 |
USP19 binds CDK1. 1 / 1
1 |
biogrid
No evidence text available
19615732
CAMK2_complex affects USP19
| 1
CAMK2_complex binds USP19. 1 / 1
| 1
reach
"Interestingly, Usp19 also interacts with CaMK-II and since alphakap forms complexes with CaMK-II, it is possible that alphakap may function as a scaffold for Usp19."
22496563
CAMK2G affects USP19
1 |
USP19 binds CAMK2G. 1 / 1
1 |
biogrid
No evidence text available
19615732
CACYBP affects USP19
1 |
USP19 binds CACYBP. 1 / 1
1 |
biogrid
No evidence text available
26344197
BHLH affects USP19
| 1
USP19 binds HIF1A and BHLH. 1 / 1
| 1
sparser
"This was based on findings showing that USP19 can interact with the bHLH-PAS domain of HIF-1α, but not HIF-2α, and with SIAH1 and SIAH2, which are known components of the hypoxia pathway since they regulate the presence of PHD 1/3 enzymes [ xref , xref ]."
31208103
AZM551248 affects USP19
1 |
AZM551248 increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
22323515
ATR affects USP19
| 1
ATR phosphorylates USP19. 1 / 1
| 1
reach
"In addition, USP19 is phosphorylated by ATM or ATR in response to DNA damage [14]."
23500468
ATM affects USP19
| 1
ATM phosphorylates USP19. 1 / 1
| 1
reach
"In addition, USP19 is phosphorylated by ATM or ATR in response to DNA damage [14]."
23500468
ATAD1 affects USP19
1 |
USP19 binds ATAD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
AIP affects NADSYN1
| 1
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
AIP affects FKBP51, and USP19
| 1
USP19 binds AIP and FKBP51. 1 / 1
| 1
sparser
"We confirmed interaction of ubiquitin carboxypeptidase Usp19 with two dcTPR proteins, AIP and FKBP51, via the dicarboxylate clamp mechanism."
30410862
AIP affects DNAAF2, NADSYN1, and USP19
| 1
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
AIP affects DNAAF2, HSPH1, NADSYN1, PTGES3, and USP19
| 1
USP19 binds PTGES3, HSPH1, DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"AIP interactions with Usp19, DNAAF2, NADSYN1, p23, Hsp105, and BclG are shown in Fig.  xref C and FKBP51 interactions with these proteins were found to be similar to those of AIP (not shown)."
30410862
AIP affects DNAAF2, FKBP51, HSPH1, NADSYN1, and USP19
| 1
USP19 binds HSPH1, DNAAF2, NADSYN1, AIP, and FKBP51. 1 / 1
| 1
sparser
"While none of the assayed proteins interacted with GST alone (not shown), the pull‐down assay revealed that Usp19, DNAAF2, NADSYN1, Hsp105, and Bcl‐G interact with both AIP and FKBP51 and these interactions were dependent on the presence of an intact C terminus (Fig.  xref B), confirming the importance of their C termini for interaction with dcTPR proteins."
30410862
AIP affects DNAAF2, FKBP51, HSPH1, NADSYN1, PTGES3, and USP19
| 1
USP19 binds PTGES3, HSPH1, DNAAF2, NADSYN1, AIP, and FKBP51. 1 / 1
| 1
sparser
"To confirm dicarboxylate clamp interaction mechanism for several potential protein pairs that have been previously identified xref , we probed interactions of Usp19, DNAAF2, NADSYN1, p23, Hsp105 and Bcl‐G with the dcTPR proteins AIP and FKBP51."
30410862
AIP affects DNAAF2
| 1
USP19 binds DNAAF2, NADSYN1, and AIP. 1 / 1
| 1
sparser
"We obtained moderate to strong labeling for Usp19, DNAAF2, and NADSYN1 interactions with AIP and surprisingly strong labeling of AIP–p23 interactions."
30410862
ACADSB affects USP19
1 |
USP19 binds ACADSB. 1 / 1
1 |
biogrid
No evidence text available
19615732
2,4-D affects USP19
1 |
2,4-D increases the amount of USP19. 1 / 1
1 |
ctd
No evidence text available
15878651