IndraLab
Statements
reach
"Western blotting and immunofluorescence experiments of proteins related to autophagy showed that USP19 overexpression substantially reduced the protein expression of P62 in LoVo and SW480 cells while significantly elevating the protein expression of Beclin1 and LC3, as compared to the L-OHP group (Fig. 4B–D)."
USP19 is modified
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19
USP19 is palmitoylated.
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USP19 is ubiquitinated.
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3
USP19 is phosphorylated.
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USP19 is methylated.
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sparser
"At a raw p -value < 0.05 for the present study, only a few associations replicated in the same direction as previous PFAS epigenome-wide association studies: PFOS with increased methylation in ANO3 (cg05146852) [ xref ] and PFNA with decreased methylation in HIF1A (cg04509825) and TTL (cg03065329) and increased methylation in PTGIS (cg27059136) and USP19 (cg01673931) [ xref ]."
USP19 affects cell population proliferation
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USP19 activates cell population proliferation.
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USP19 inhibits cell population proliferation.
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USP19 inhibits cell population proliferation. 8 / 8
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"Depletion of USP19 inhibited proliferation in prostate cancer DU145, PC-3 and 22RV1 cells, which was similar to the pattern established in fibroblasts in that it was due to decreased progression from G1 to S phase and associated with a stabilization of the cyclin-dependent kinase inhibitor p27 Kip1 ."
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"Depletion of USP19 inhibited proliferation in prostate cancer DU145, PC-3 and 22RV1 cells, which was similar to the pattern established in fibroblasts in that it was due to decreased progression from G1 to S phase and associated with a stabilization of the cyclin dependent kinase inhibitor p27 Kip1."
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"Therefore, we initiated this study to investigate whether USP19, a previously identified DUB for PAHwt , can increase cellular levels of PAH variants through deubiquitinating activity.Notably, USP19 is an endoplasmic reticulum (ER)-specific DUB and participates in the export of misfolding-associated protein, which are associated with neurodegenerative diseases ."
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"Overexpression of USP19 inhibited RARE transcription and knock-down of USP19 using siRNA showed dramatically increased transcription of RARE, suggesting that USP19 increases the stability of CORO2A by DUB activity, and that binding of these two protein may be associated with the function of NCoR."
Genome polyprotein affects USP19
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Genome polyprotein increases the amount of USP19.
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Genome polyprotein activates USP19.
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"The fact that TDP-43 was found to be released in a VAMP7-dependent manner is certainly coherent with this notion.In our study, we observed that inhibiting DNAJC5/CSPα function using a dominant negative construct (S10A-CSPα), or through DNAJC5/CSPα siRNAs, significantly reduced the release of misfolded TDP-43 mediated by USP19."
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"Nevertheless, the implication of early autophagy processes was further supported by a significant decrease in USP19-mediated misfolded TDP-43 secretion upon inhibition of ATG7, RAB11A or VAMP7 components, all of which are involved in the early steps of phagophore/autophagosome biogenesis [47, 59, 70]."
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"These findings strongly suggest that the USP19-mediated MAPS pathway conducts a specific sorting of misfolded TDP-43, leading to its secretion as soluble and free aggregates rather than through exosomes.The exact molecular and cellular mechanisms by which cells select misfolded proteins for secretion via the USP19 dependent MAPS pathway remain enigmatic."
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"Additionally, co-immunoprecipitation experiments demonstrated interactions between USP19 and TDP-43 thus suggesting that part of TDP-43 could be secreted in a form of a tri-complex ER-USP19-TDP-43 engulfed into secretory compartments.To gain a clearer understanding of the cellular mechanisms involved in the misfolded TDP-43 secretion via the MAPS pathway, we evaluated the impact of the Spautin1 and LY294002 inhibitors on the early steps of phagophores/autophagosomes biogenesis [45, 46]."
USP19 affects cell differentiation
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USP19 inhibits cell differentiation.
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USP19 activates cell differentiation.
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sparser
"The regulatory function of USP19 was recently confirmed in a study demonstrating that USP19 interacts directly with chaperone Hsp90 and upregulates the aggregation of poly-Q containing the proteins Ataxin-3 and Huntingtin, which causes spinocerebellar ataxia type-3 and Huntington’s disease, respectively [ xref ]."
USP19 affects apoptotic process
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USP19 activates apoptotic process.
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USP19 inhibits apoptotic process.
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USP19 inhibits apoptotic process. 4 / 5
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"Among the additional 26 genes, we noted that module 28 included USP19 and LRRFIP2, which can inhibit apoptosis or pyroptosis and were higher in HIV-DNA cells, and TLN1 , which is required for antigen-driven T cell proliferation mediated through immunological synapses and was also higher in HIV-DNA cells."
sparser
"The regulatory function of USP19 was recently confirmed in a study demonstrating that USP19 interacts directly with chaperone Hsp90 and upregulates the aggregation of poly-Q containing the proteins Ataxin-3 and Huntingtin, which causes spinocerebellar ataxia type-3 and Huntington’s disease, respectively [ xref ]."
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"S4D), suggesting VANGL2-induced degradation of TBK1 to inhibit IFN-I signaling.Most literature showed that the degradation of TBK1 is relied on the proteasome, except for a few recent studies that indicated that USP19, NEDD4, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 13 (NSP13) could induce the autophagic degradation of TBK1 (7, 25, 26)."
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"Down-regulation of USP19 increased the phosphorylation levels of TBK1 and IRF3 and inhibited autophagy induced by IAV infection due to the ubiquitination of Beclin1[129], indicating that Cyanidin and C3G showed anti-influenza virus activity against IAV infection by regulating USP19-Beclin1-dependent autophagy."
reach
"Also, worth investigating is whether USP19 inhibitors are promising drugs against tumors in general, or only some specific types of tumors, like liver cancers with p53 deletions/mutations that originate in a NAFLD background.In conclusion, this study shows that p53 deletion/mutation increases USP19, which in turn stabilizes SOAT1, increases cholesterol esterification and accelerates tumor progression (Figure 1)."
USP19 affects Neoplasm Invasiveness
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USP19 activates Neoplasm Invasiveness. 10 / 11
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"We demonstrated that USP19 positively regulates breast tumor cells migration and invasion in vitro, and that genetic silencing reduces cells motility, whereas its overexpression increases migratory and invasive capabilities—dependent on USP19’s catalytic activity and ER localization."
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"Saito and Tanaka (51) revealed that inhibiting the Notch and NF-κB pathway prevents the progression of OA, whilst Lei et al (52) observed that ubiquitin specific peptidase 19 suppresses TNF-α and IL-1β-induced NF-κB activation by deubiquitinating mitogen-activated protein kinase kinase kinase 7."
"We show that folding of the Wnt signaling coreceptor <span class="match term1">LRP6</span> is promoted by ubiquitination of a specific lysine, retaining it in the ER while avoiding degradation. Subsequent ER exit requires removal of ubiquitin from this lysine by the deubiquitinating enzyme <span class="match term0">USP19</span>."
USP19 affects Interferon
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USP19 inhibits Interferon.
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USP19 activates Interferon.
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sparser
"SIAH2 binds to USP19 and promotes USP19 ubiquitylation and proteasome‐dependent degradation xref ; then, the hypothesis of a causal link between SIAH2 and USP19 in cardiomyocyte hypertrophy was established: Decreased transcription of SIAH2 during hypertrophic progress led to less degradation of USP19, and this mechanism partially accounted for USP19 elevation."
sparser
"SIAH2 binds to USP19 and promotes USP19 ubiquitylation and proteasome‐dependent degradation xref ; then, the hypothesis of a causal link between SIAH2 and USP19 in cardiomyocyte hypertrophy was established: Decreased transcription of SIAH2 during hypertrophic progress led to less degradation of USP19, and this mechanism partially accounted for USP19 elevation."
reach
"The result suggests USP19 as a rating limiting factor in UFMylation-dependent UcPS: Only in USP19 high cells, increased UFMylation can lead to more secretion, demonstrating a functional interplay between USP19 and UFM1 in UcPS.We next explored the possibility that USP19 might directly bind UFM1."
USP19 affects HDAC1/2
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USP19 binds HDAC1/2.
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"Based on this observation, and considering that USP19 interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair and chromosomal stability (Wu et al., 2017) and that both ccRCC and HGSC are characterized by high genomic instability, it is plausible that USP19-mediated deubiquitination of key regulators associated with DSB repair or genome instability might be responsible for the worse prognosis observed in ccRCC and HGSC patients with low USP19 levels (Kang et al., 2021)."
USP19 deubiquitinates HDAC1/2.
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"Based on this observation, and considering that USP19 interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair and chromosomal stability (Wu et al., 2017) and that both ccRCC and HGSC are characterized by high genomic instability, it is plausible that USP19-mediated deubiquitination of key regulators associated with DSB repair or genome instability might be responsible for the worse prognosis observed in ccRCC and HGSC patients with low USP19 levels (Kang et al., 2021)."
sparser
"SIAH2 binds to USP19 and promotes USP19 ubiquitylation and proteasome‐dependent degradation xref ; then, the hypothesis of a causal link between SIAH2 and USP19 in cardiomyocyte hypertrophy was established: Decreased transcription of SIAH2 during hypertrophic progress led to less degradation of USP19, and this mechanism partially accounted for USP19 elevation."
reach
"The result suggests USP19 as a rating limiting factor in UFMylation-dependent UcPS: Only in USP19 high cells, increased UFMylation can lead to more secretion, demonstrating a functional interplay between USP19 and UFM1 in UcPS.We next explored the possibility that USP19 might directly bind UFM1."
sparser
"This hypothesis was supported by co‐immunoprecipitation assays, which demonstrated that wild‐type ZDHHC2 overexpression significantly reduced the ACSL4‐USP19 protein–protein interaction (Figure xref ; Figure xref , Supporting Information ), but did not influence the binding between ACSL4 and the USP19 C152S mutant, which cannot be palmitoylated by ZDHHC2 (Figure xref )."
USP19 affects signal transduction
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USP19 inhibits signal transduction.
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USP19 activates signal transduction.
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USP19 affects calcium(2+)
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USP19 increases the amount of calcium(2+).
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USP19 increases the amount of calcium(2+). 5 / 5
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"Fluorescence microscopy revealed a substantial rise in intracellular Ca concentration in BCL2 plasmid transfected cells, indicating that BCL2 could enhance Ca levels in Figure S3E.To further clarify the regulatory role of BCL2 ubiquitination by USP19 and BAG6, MDA‐MB‐231 cells were co‐transfected with Myc‐USP19, siUSP19, Flag‐BAG6, siBAG6 and HA‐Ub."
USP19 activates calcium(2+).
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USP19 activates calcium(2+). 1 / 1
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USP19 increases the amount of USP19.
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USP19 decreases the amount of USP19.
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"Overexpression of USP19 inhibited RARE transcription and knock-down of USP19 using siRNA showed dramatically increased transcription of RARE, suggesting that USP19 increases the stability of CORO2A by DUB activity, and that binding of these two protein may be associated with the function of NCoR."
USP19 activates USP19.
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1
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"Conversely, knockout of USP19 causes significant decreases in the abundance of Nrf1 and the entrance of its active isoform into the nucleus, which result in the downregulation of its target proteasomal subunits and a modest reduction in USP19 -/- -derived tumor growth in xenograft mice when compared with wild-type controls."
reach
"Notably, our recent work further unraveled that the deubiquitinating enzyme USP19 enables activation of its co-localized NFE2L1 in proximity to the ER and, in turn, NFE2L1 in close cooperation with NFE2L2/Nrf2 can tightly govern the transcriptional expression of USP19 and other DUBs insomuch as to form a positive feedback regulatory circuit [49]."
USP19 affects GFP1
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HDAC1/2 affects USP19
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reach
"Based on this observation, and considering that USP19 interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair and chromosomal stability (Wu et al., 2017) and that both ccRCC and HGSC are characterized by high genomic instability, it is plausible that USP19-mediated deubiquitination of key regulators associated with DSB repair or genome instability might be responsible for the worse prognosis observed in ccRCC and HGSC patients with low USP19 levels (Kang et al., 2021)."
Lipopolysaccharide affects USP19
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Lipopolysaccharide activates USP19.
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Lipopolysaccharide inhibits USP19.
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Lipopolysaccharide inhibits USP19. 1 / 1
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Lipopolysaccharide decreases the amount of USP19.
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Lipopolysaccharide decreases the amount of USP19. 1 / 1
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USP19 affects α-synuclein
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"To investigate whether MAPS is involved in cell-to-cell transmission of misfolded proteins observed in neurodegenerative diseases , we tested whether USP19 promotes the secretion of α-synuclein, a natively unfolded cytosolic protein known to be released from cells through exosomes as well as an undefined mechanism ."
USP19 affects cell migration
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USP19 affects Non-structural protein 5A
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"Our previous study has demonstrated that cytoplasmic ubiquitin specific protease 19 (USP19), through interacting with HSP90, up-regulates the protein levels of the N-terminal 552-residue fragments of Htt (Htt-N552) with normal and expanded polyQ, and consequently increases the aggregates formed by polyQ expanded Htt-N552 31."
USP19 affects Endoplasmic Reticulum Stress
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USP19 activates Endoplasmic Reticulum Stress. 5 / 5
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"Collectively, USP19 can significantly increase the unfolded protein entering the ER and induce ER stress, by reducing BAG6 ubiquitination to kill TNBC cells.m A methylation had received a lot of attention recently and was now widely acknowledged as the most frequent and prolific alteration on mRNA and as a mechanism to control RNA translation, stability, and degradation."
reach
"We next examined the effect of usp19 silencing on the protein levels of Atx3 100Q and Htt-N552 100Q, and observed that knockdown of USP19 significantly reduced the protein levels of Atx3 100Q (XREF_FIG) and Htt-N552 100Q (XREF_FIG) both in HEK 293T cells and in human retinal pigment epithelial (RPE1) cells (XREF_SUPPLEMENTARY)."
reach
"The regulatory function of USP19 was recently confirmed in a study demonstrating that USP19 interacts directly with chaperone Hsp90 and upregulates the aggregation of poly-Q containing the proteins Ataxin-3 and Huntingtin, which causes spinocerebellar ataxia type-3 and Huntington’s disease, respectively [90]."
sparser
"This hypothesis was supported by co‐immunoprecipitation assays, which demonstrated that wild‐type ZDHHC2 overexpression significantly reduced the ACSL4‐USP19 protein–protein interaction (Figure xref ; Figure xref , Supporting Information ), but did not influence the binding between ACSL4 and the USP19 C152S mutant, which cannot be palmitoylated by ZDHHC2 (Figure xref )."
Non-structural protein 5A affects USP19
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sparser
"This hypothesis was supported by co‐immunoprecipitation assays, which demonstrated that wild‐type ZDHHC2 overexpression significantly reduced the ACSL4‐USP19 protein–protein interaction (Figure xref ; Figure xref , Supporting Information ), but did not influence the binding between ACSL4 and the USP19 C152S mutant, which cannot be palmitoylated by ZDHHC2 (Figure xref )."
Bisphenol A affects USP19
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Bisphenol A increases the amount of USP19.
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Bisphenol A demethylates USP19.
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USP19 affects tropomyosin
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USP19 affects proteolysis
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USP19 affects protein secretion
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USP19 activates protein secretion.
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USP19 activates protein secretion. 3 / 3
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"This likely represents a small fraction of physiological MAPS cargoes because the experiments were conducted under serum-depleted culture condition, which, while being necessary to eliminate serum contaminants from the secretome and allow mass spectrometry, is known to diminish USP19-mediated unconventional protein secretion (21)."
USP19 inhibits protein secretion.
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USP19 inhibits protein secretion. 1 / 1
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USP19 affects pathogenic potential Th17 cells
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USP19 affects lipopolysaccharide
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USP19 affects endoplasmic reticulum
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USP19 activates endoplasmic reticulum.
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USP19 activates endoplasmic reticulum. 2 / 2
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"Notably, our recent work further unraveled that the deubiquitinating enzyme USP19 enables activation of its co-localized NFE2L1 in proximity to the ER and, in turn, NFE2L1 in close cooperation with NFE2L2/Nrf2 can tightly govern the transcriptional expression of USP19 and other DUBs insomuch as to form a positive feedback regulatory circuit [49]."
USP19 inhibits endoplasmic reticulum.
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USP19 inhibits endoplasmic reticulum. 1 / 1
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USP19 deubiquitinates endoplasmic reticulum.
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USP19 deubiquitinates endoplasmic reticulum. 1 / 1
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USP19 affects cell growth
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"Western blotting and immunofluorescence experiments of proteins related to autophagy showed that USP19 overexpression substantially reduced the protein expression of P62 in LoVo and SW480 cells while significantly elevating the protein expression of Beclin1 and LC3, as compared to the L-OHP group (Fig. 4B–D)."
reach
"Simultaneously, the deubiquitinating enzyme ubiquitin specific peptidase 19 (USP19), which is located in the endoplasmic reticulum, accumulates at the MAM and binds to the mitochondrial outer membrane protein FUNDC1, inducing its deubiquitination, promoting the oligomerization of dynamin-related protein 1 (DRP1), and resulting in mitochondrial fission (Zhang et al., 2022)."
Resveratrol affects USP19
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Resveratrol inhibits USP19.
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Resveratrol inhibits USP19. 1 / 1
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Resveratrol decreases the amount of USP19.
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Resveratrol decreases the amount of USP19. 1 / 1
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Resveratrol activates USP19.
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Resveratrol activates USP19. 1 / 1
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Dexamethasone affects USP19
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USP19 affects pTh17
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USP19 affects lysosomal proteins
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USP19 affects inflammatory response
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USP19 affects cholesterol esterification
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USP19 activates cholesterol esterification. 3 / 3
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"Also, worth investigating is whether USP19 inhibitors are promising drugs against tumors in general, or only some specific types of tumors, like liver cancers with p53 deletions/mutations that originate in a NAFLD background.In conclusion, this study shows that p53 deletion/mutation increases USP19, which in turn stabilizes SOAT1, increases cholesterol esterification and accelerates tumor progression (Figure 1)."
reach
"For example, myocardial-specific expression of A20, a DUB, improves left ventricular function and alleviates compensatory myocardial hypertrophy induced by myocardial infarction.7 Another 2 DUBs, USP4 and USP18, attenuate hypertension-induced pathological cardiac hypertrophy by directly binding to TAK1.8 9 In addition, the deubiquitinase OTUD1 regulates the progression of diabetic cardiomyopathy by regulating YB-1 and inhibiting its activation10 and USP19 alleviates doxorubicin-induced cardiomyopathy by deubiquitinating TRAF2 and preventing its degradation."
USP19 affects TLR3/4
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USP19 affects Stomach Neoplasms
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USP19 activates Stomach Neoplasms. 3 / 3
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"Enhanced USP19 expression promoted GC cell proliferation and metastasis through reduced cleaved caspase-3 and increased MMP2 and MMP9 expression and promoted enzyme activity in the study, and verified the results through The Cancer Genome Atlas (TCGA) and bioinformatic websites from the Kaplan-Meier plotter (http://kmplot.com) and GEPIA (http://gepia2.cancer-pku.cn.)"
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"Conversely, USP19 over-expression increased SOAT1 and accelerated HCC progression.To further test the hypothesis that USP19 loss inhibits HCC progression in response to p53 loss and that this is related to decreased SOAT1 expression, USP19 and SOAT1 expression was examined in human HCCs in The Cancer Genome Atlas database and confirmed that both messenger RNAs (mRNAs) were up-regulated."
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"Conversely, USP19 over-expression increased SOAT1 and accelerated HCC progression.To further test the hypothesis that USP19 loss inhibits HCC progression in response to p53 loss and that this is related to decreased SOAT1 expression, USP19 and SOAT1 expression was examined in human HCCs in The Cancer Genome Atlas database and confirmed that both messenger RNAs (mRNAs) were up-regulated."
USP19 affects Deubiquitinase
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USP19 activates Deubiquitinase. 1 / 3
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USP19 affects DNA-templated transcription
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USP19 activates DNA-templated transcription.
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USP19 activates DNA-templated transcription. 2 / 2
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"100 Loss of USP19 increases transcription of myofibrillar proteins in L6 muscle cells and decreases muscle wasting in response to denervation in mice Priyanka Sundaram 1, Zhiyu Pang 2, Miao Miao 1, Nathalie Bedard 2, Tamara Moore 2, Patricia L. Hallauer 3, Kenneth E. Hastings 3, Simon S. Wing 2 1 Department of Biochemistry, McGill University, Montreal, QC, Canada; 2 Department of Medicine, McGill University, Montreal, QC, Canada; 3 Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada Background and aims : Although many enzymes involved in ubiquitination are activated in atrophying muscle, little is known about the role of deubiquitinating enzymes (DUBs)."
USP19 inhibits DNA-templated transcription.
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USP19 inhibits DNA-templated transcription. 1 / 1
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sparser
"Overexpression of USP19 inhibited RARE transcription and knock-down of USP19 using siRNA showed dramatically increased transcription of RARE (Figure xref and Figure xref ), suggesting that USP19 increases the stability of CORO2A by DUB activity, and that binding of these two protein may be associated with the function of NCoR."
Air Pollutants affects USP19
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Titanium dioxide affects USP19
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Titanium dioxide methylates USP19.
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Titanium dioxide demethylates USP19.
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Sodium arsenite affects USP19
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Sodium arsenite increases the amount of USP19.
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Sodium arsenite decreases the amount of USP19.
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Paracetamol affects USP19
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Paracetamol increases the amount of USP19.
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Paracetamol decreases the amount of USP19.
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Methacrylaldehyde affects USP19
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Aflatoxin B1 affects USP19
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USP19 affects ubiquitin proteasome
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USP19 affects response
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USP19 affects receptor-alpha
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USP19 affects myoblast fusion
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USP19 affects metabolic process
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USP19 affects lipid metabolic process
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USP19 activates lipid metabolic process. 2 / 2
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USP19 affects immune response
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USP19 affects fusion protein
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USP19 affects ferroptosis
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USP19 affects cellular component biogenesis
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USP19 affects cell death
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USP19 activates cell death. 2 / 2
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"This indicates that the 494–1318 domain of USP19 contains the essential functional properties for misfolded TDP-43 secretion.To ensure that the observed secretion of misfolded TDP-43 was not simply the reflect of cell death potentially induced by the combined expression of USP19-WT and TDP-43-K263E, we assessed cell viability using the trypan blue exclusion method."
USP19 affects cell cycle
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USP19 activates cell cycle. 2 / 2
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"The knockdown of the USP19 gene could inhibit the progression of PCa in two ways; first, by causing defects in cell cycle progression and delaying the progression from G0/G1 to S phase, and second, by accumulating p27 and inhibiting the ability of USP19 to regulate cell growth (Lu et al., 2011)."
USP19 affects Th17
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USP19 affects TCRalpha
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USP19 affects SIAH
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"(1) Constitutive binding partners, often as part of larger macromolecular complexes, e.g., USP22/SAGA-DUBm [167] and CSN5/COP9 signalosome [168] ; (2) low-affinity, transient binding partners, e.g., the USP19/SIAH complex [169] and USP8/NRDP1 [170] , or protein modifiers such as kinases, e.g., USP10/AMPKα [171] ; and (3) ubiquitinated substrates that bind DUBs by virtue of the Ub modification."
USP19 affects PAHwt
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USP19 affects PAHwt protein
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USP19 affects Neoplasm Metastasis
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USP19 affects Mnf2
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USP19 affects ISRE
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USP19 affects GFP1-10
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reach
"The knockdown of the USP19 gene could inhibit the progression of PCa in two ways; first, by causing defects in cell cycle progression and delaying the progression from G0/G1 to S phase, and second, by accumulating p27 and inhibiting the ability of USP19 to regulate cell growth (Lu et al., 2011)."
USP19 affects EWS-FLI1 protein
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USP19 affects E3_Ub_ligase
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USP19 affects DNA Damage
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USP19 affects Carcinogenesis
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"Additionally, co-immunoprecipitation experiments demonstrated interactions between USP19 and TDP-43 thus suggesting that part of TDP-43 could be secreted in a form of a tri-complex ER-USP19-TDP-43 engulfed into secretory compartments.To gain a clearer understanding of the cellular mechanisms involved in the misfolded TDP-43 secretion via the MAPS pathway, we evaluated the impact of the Spautin1 and LY294002 inhibitors on the early steps of phagophores/autophagosomes biogenesis [45, 46]."
SIAH affects USP19
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2
reach
"(1) Constitutive binding partners, often as part of larger macromolecular complexes, e.g., USP22/SAGA-DUBm [167] and CSN5/COP9 signalosome [168] ; (2) low-affinity, transient binding partners, e.g., the USP19/SIAH complex [169] and USP8/NRDP1 [170] , or protein modifiers such as kinases, e.g., USP10/AMPKα [171] ; and (3) ubiquitinated substrates that bind DUBs by virtue of the Ub modification."
Reactive Oxygen Species affects USP19
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EV71 affects USP19
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1,4-dithiothreitol affects USP19
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1,4-dithiothreitol activates USP19. 2 / 2
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"They further showed that some DUBs that have been exposed to ROS can have different responses to reduction through DTT treatment, with some being activated by DTT (e.g., USP8, USP10, and USP19), some having only enhancement of activity in the presence of DTT (e.g., USP7, CYLD, and UCHL5), and others exhibiting no activity, despite the presence of a reducing agent (e.g., USP1, USP22, and A20) (35)."
ShUSP19-1 affects USP19
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Perfluorooctanesulfonamide affects USP19
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P97 affects USP19
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Malonaldehyde affects USP19
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Malonaldehyde inhibits USP19. 1 / 1
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Ivermectin affects USP19
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Inducible shUSP19 constructs affects USP19
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Hsa-miR-196a-5p affects USP19
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Hexadecanoic acid affects USP19
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Hexadecanoic acid palmitoylates USP19. 1 / 1
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Hexabromocyclododecane affects USP19
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Gallic acid affects USP19
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Folic acid affects USP19
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Deltamethrin affects USP19
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Cadmium dichloride affects USP19
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Arsenite(3-) affects USP19
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Aristolochic acid A affects USP19
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USP19 affects α-syn
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USP19 affects vice active USP19 stabilized fusion protein
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USP19 affects ubiquitination RORgammat-K313 RORgammat-K69 K446
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USP19 affects ubiquitin peptidase
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USP19 affects translation
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USP19 activates translation. 1 / 1
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USP19 affects transactivity
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USP19 affects temozolomide
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USP19 activates temozolomide. 1 / 1
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USP19 affects suggesting have oncogenic properties33
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USP19 affects stability MARCHF6
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USP19 affects several mitotic defects including cytokinesis
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USP19 affects self-ubiquitin ligase
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USP19 affects response to hypoxia
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USP19 activates response to hypoxia. 1 / 1
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USP19 affects prostate cancer breast epithelial cell lines
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USP19 affects polyubiquitination PAH
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USP19 affects polyubiquitin chains
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USP19 affects pathogenic potential
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USP19 affects pathogenesis
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USP19 activates pathogenesis. 1 / 1
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USP19 affects pTh17 differentiation
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USP19 affects p97
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USP19 affects muscle hypertrophy
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USP19 activates muscle hypertrophy. 1 / 1
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USP19 affects localization
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1
USP19 activates localization. 1 / 1
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1
USP19 affects lipogenesis colorectal carcinogenesis
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1
USP19 affects hypoxia-induced mitochondrial division
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1
USP19 affects hypertrophic
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1
USP19 affects growth tumors mouse xenograft
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1
USP19 affects green fluorescent protein
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1
USP19 increases the amount of green fluorescent protein. 1 / 1
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1
USP19 affects glutathione
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1
USP19 activates glutathione. 1 / 1
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1
USP19 affects extending half-life PAH protein
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1
USP19 affects exocytosis
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1
USP19 activates exocytosis. 1 / 1
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1
USP19 affects enzymatic PAH
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1
USP19 affects dexamethasone
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1
USP19 activates dexamethasone. 1 / 1
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1
USP19 affects cellular migration
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1
USP19 affects autophagy inhibitor
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1
USP19 activates autophagy inhibitor. 1 / 1
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1
USP19 affects autophagic cell death
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1
USP19 activates autophagic cell death. 1 / 1
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1
USP19 affects Ubiquitination
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1
USP19 inhibits Ubiquitination. 1 / 1
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1
USP19 affects USP19-ME1
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1
USP19 affects USP
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1
USP19 affects UPS19
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1
USP19 affects UBL
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1
USP19 affects Tumor Microenvironment
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1
USP19 activates Tumor Microenvironment. 1 / 1
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1
USP19 affects Th17-driven pathogenesis autoimmunity T helper
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1
USP19 affects SAH mice
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1
USP19 affects Reactive Oxygen Species
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1
USP19 inhibits Reactive Oxygen Species. 1 / 1
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1
USP19 affects Population
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1
USP19 inhibits Population. 1 / 1
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1
USP19 affects NLRP3 inflammasome
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1
USP19 affects K63-
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1
USP19 affects K48
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1
USP19 affects K27
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1
USP19 affects Insulin Resistance
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1
USP19 activates Insulin Resistance. 1 / 1
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1
USP19 affects Hypertrophy
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1
USP19 inhibits Hypertrophy. 1 / 1
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1
reach
"The USP19 attenuates pathological cardiac hypertrophy by inhibiting the TAK1-dependent pathway (Miao et al. 2020), and in addition, Tang et al. found that USP7 reduces myocardial ischemia-reperfusion injury by regulating ferroptosis (Tang et al. 2021), suggesting an important role for the presence of USP in the heart."
USP19 affects Htt-N90
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1
USP19 affects Genomic Instability
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1
USP19 inhibits Genomic Instability. 1 / 1
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1
reach
"Western blotting and immunofluorescence experiments of proteins related to autophagy showed that USP19 overexpression substantially reduced the protein expression of P62 in LoVo and SW480 cells while significantly elevating the protein expression of Beclin1 and LC3, as compared to the L-OHP group (Fig. 4B–D)."
USP19 affects FKBP51
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1
USP19 affects EWSR1-FLI1
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1
USP19 affects EWS-FLI1
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1
USP19 affects EWS-FLI1 fusion oncoprotein
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1
USP19 affects ERAD machinery factors
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1
USP19 affects CFTRDeltaF508
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1
USP19 affects CFTR ER-associated degradation
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1
USP19 affects CAMK2_complex
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1
USP19 binds CAMK2_complex. 1 / 1
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1
USP19 affects Breast Neoplasms
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1
USP19 activates Breast Neoplasms. 1 / 1
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1
reach
"We demonstrated that USP19 positively regulates breast tumor cells migration and invasion in vitro, and that genetic silencing reduces cells motility, whereas its overexpression increases migratory and invasive capabilities—dependent on USP19’s catalytic activity and ER localization."
USP19 affects Body Weight
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1
USP19 inhibits Body Weight. 1 / 1
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1
USP19 affects Auxin response factor
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1
Auxin response factor binds USP19. 1 / 1
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1
USP19 affects A549
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1
USP affects USP19
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1
UBL affects USP19
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1
Stomach Neoplasms affects USP19
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1
Stomach Neoplasms activates USP19. 1 / 1
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1
Reperfusion Injury affects USP19
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1
Reperfusion Injury increases the amount of USP19. 1 / 1
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1
Raloxifene Hydrochloride affects USP19
1
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PFF affects USP19
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1
K63- affects USP19
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1
K48 affects USP19
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1
K27 affects USP19
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1
HSPA8 LAMP2A affects USP19
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1
Gentamicins affects USP19
1
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GFP-VAMP7-Longin affects USP19
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1
FKBP51 affects USP19
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1
ERAD machinery factors affects USP19
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1
CAMK2_complex affects USP19
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1
USP19 binds CAMK2_complex. 1 / 1
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1
C2-FFL affects USP19
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1
BIRC5 affects A549
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1
Auxin response factor affects USP19
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1
Auxin response factor binds USP19. 1 / 1
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1
Acrylamide affects USP19
1
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A549 affects USP19
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1
1
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4,4'-sulfonyldiphenol affects USP19
1
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