IndraLab

Statements

USP16 is modified
54 | 29 16
USP16 is phosphorylated.
54 | 27 16
USP16 is phosphorylated. 10 / 29
| 22 7
sparser
"We used an in vitro phosphorylation assay to demonstrate phosphorylation of USP16 by Aurora B ( Figure S6 B)."
24034696
sparser
"In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
sparser
"In agreement with this, CDK1-mediated phosphorylation of USP16 increases its interaction with PLK1, and USP16 knockdown increases the ubiquitination level of PLK1 and decreases its association with kinetochores, which could yield improper chromosome alignment [ xref ] ( xref E)."
36980227
rlimsp
"RT-PCR with Usp16 specific primers confirmed equivalent mRNA expression, suggesting that Usp16 phosphorylation promotes protein degradation."
28380042
sparser
"Importantly, the combined use of CDK1 and Plk1 enhanced the phosphorylation of the peptide aa 150–600 ( xref ), which is consistent with our early finding that CDK1 is the priming kinase for Plk1 in Usp16 phosphorylation."
26323689
sparser
"Collectively, our results strongly suggest that CDK1 promotes the interaction between Plk1 and Usp16 and enhances the phosphorylation of Usp16 by Plk1."
26323689
rlimsp
"We propose that this triple phosphorylation and subsequent degradation of Usp16 may represent another mechanism whereby TTK regulates genome stability by preventing Plk1 deubiquitination leading to its expulsion from the kinetochore, as well as preventing chromosomal condensation by inhibiting histone H2A deubiquitination, thus allowing more time to correct for errors that accumulated during DNA replication."
28380042
rlimsp
"Importantly, the combined use of CDK1 and Plk1 enhanced the phosphorylation of the peptide aa 150–600 (Fig. 3 B), which is consistent with our early finding that CDK1 is the priming kinase for Plk1 in Usp16 phosphorylation."
26323689
sparser
"These results strongly suggest that Plk1 phosphorylates and activates Usp16, but the exact molecular mechanism of the activation is not clear at the moment."
26323689
sparser
"Plk1 phosphorylates and activates Usp16."
26323689
USP16 is phosphorylated on S552. 10 / 19
10 | 5 4
hprd
No evidence text available
20058876
hprd
No evidence text available
20068231
hprd
No evidence text available
19413330
hprd
No evidence text available
18669648
hprd
No evidence text available
17322306
sparser
"O-GlcNAcylation antagonizes CDK1-mediated USP16 Ser552 phosphorylation."
38462164
hprd
No evidence text available
20058876
hprd
No evidence text available
20068231
hprd
No evidence text available
19413330
hprd
No evidence text available
18669648
USP16 is phosphorylated on T554. 10 / 14
12 | 2
hprd
No evidence text available
19651622
rlimsp
"We identified three TTK-dependent phosphorylation sites on Usp16: S415, S552, and T554."
28380042
rlimsp
"Taken together, these data suggest that Usp16 is a phosphorylation substrate of TTK and that Usp16 phosphorylation on S415, S552, or T554 leads to proteasome degradation of Usp16."
28380042
hprd
No evidence text available
20068231
hprd
No evidence text available
19651622
hprd
No evidence text available
19413330
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
hprd
No evidence text available
19651622
hprd
No evidence text available
19413330
USP16 is phosphorylated on S415. 10 / 12
12 |
hprd
No evidence text available
18452278
hprd
No evidence text available
19651622
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
hprd
No evidence text available
19651622
hprd
No evidence text available
20166139
hprd
No evidence text available
18452278
hprd
No evidence text available
20166139
hprd
No evidence text available
18452278
hprd
No evidence text available
19651622
USP16 is phosphorylated on S551. 10 / 11
11 |
hprd
No evidence text available
20058876
hprd
No evidence text available
20068231
hprd
No evidence text available
19413330
hprd
No evidence text available
18669648
hprd
No evidence text available
17322306
hprd
No evidence text available
20058876
hprd
No evidence text available
20068231
hprd
No evidence text available
20058876
hprd
No evidence text available
20068231
hprd
No evidence text available
20058876
USP16 is phosphorylated on T600. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
20068231
hprd
No evidence text available
20068231
USP16 is phosphorylated on T145. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
20068231
hprd
No evidence text available
20068231
USP16 is phosphorylated on T550. 3 / 3
3 |
hprd
No evidence text available
20058876
hprd
No evidence text available
20058876
hprd
No evidence text available
20058876
USP16 is phosphorylated. 2 / 2
| 2
rlimsp
"Earlier work had shown that USP16 is phosphorylated at the onset of mitosis and dephosphorylated during the metaphase-anaphase transition."
18226187
rlimsp
"For example, during the cell cycle, periodic phosphorylation activates USP16 and USP37 [14, 15] but inactivates USP8 through recruitment of 14-3-3 proteins [16]."
29429988
USP16 is phosphorylated on S386. 1 / 1
| 1
rlimsp
"By sequence analysis, we found three (S330, S386, and S486) potential Plk1 phosphorylation sites on Usp16 (Fig. S2 C). In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D). MS of peptides derived from proteins isolated from HeLa cells revealed two phosphorylation sites, S330 and S386 (Fig."
26323689
USP16 is methylated.
| 2
USP16 is methylated. 2 / 2
| 2
sparser
"For instance, IPA specifically binds to methionine adenosyltransferase 2A (MAT2A), enhancing S-adenosylmethionine synthesis and subsequently inducing DNA methylation of the deubiquitinating enzyme USP16."
40330490
sparser
"According to our findings, USP16 methylation is increased in breast metastatic disease, in agreement with findings in hepatocellular carcinoma [ xref ]."
33918195
PLK1 affects USP16
3 8 4 | 14 21 8
PLK1 phosphorylates USP16.
3 4 | 6 8 8
PLK1 phosphorylates USP16. 10 / 23
| 6 8 6
sparser
"Next, we set out to investigate the function of Usp16 phosphorylation by Plk1."
26323689
sparser
"We found that the level of ubiquitinated histone H2A (ubH2A) was high in interphase and low in mitotic HeLa cells (Fig. S3, C–E), suggesting that Plk1 phosphorylates and activates Usp16."
26323689
sparser
"Interestingly, when Plk1 inhibitor BI2536 was applied after the cells entered mitosis, the upshift of Usp16 was abolished ( xref ), suggesting that Usp16 was also phosphorylated by Plk1 in vivo."
26323689
rlimsp
"Plk1 phosphorylates and activates Usp16."
26323689
reach
"In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites."
26323689
reach
"Collectively, our results strongly suggest that CDK1 promotes the interaction between Plk1 and Usp16 and enhances the phosphorylation of Usp16 by Plk1."
26323689
reach
"Plk1 phosphorylates and activates Usp16."
26323689
reach
"We found that the level of ubiquitinated histone H2A (ubH2A) was high in interphase and low in mitotic HeLa cells, suggesting that Plk1 phosphorylates and activates Usp16."
26323689
reach
"These results strongly suggest that Plk1 phosphorylates and activates Usp16, but the exact molecular mechanism of the activation is not clear at the moment."
26323689
rlimsp
"Then, Plk1 further phosphorylates Usp16 to activate it."
26323689
PLK1 phosphorylates USP16 on S486. 5 / 5
1 2 | 2
signor
"In this study, we show that ubiquitin-specific peptidase 16 (Usp16) is a novel substrate for Plk1, and sequential phosphorylation by CDK1 and Plk1 activates Usp16, which, in turn, deubiquitinates Plk1 and promotes the recruitment of Plk1 to, and its retention on, the kinetochores for proper chromosome alignment.|In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig."
26323689
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
rlimsp
"By sequence analysis, we found three (S330, S386, and S486) potential Plk1 phosphorylation sites on Usp16 (Fig."
26323689
rlimsp
"In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig."
26323689
biopax:phosphositeplus
No evidence text available
PLK1 phosphorylates USP16 on S330. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
PLK1 phosphorylates USP16 on S386. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
PLK1 binds USP16.
4 | 6 8
PLK1 binds USP16. 10 / 21
4 | 6 8
reach
"Usp16 interacts with and deubiquitinates Plk1."
26323689
sparser
"The regulated interaction between USP16 and PLK1 kinetochores may cooperate with its regulation on global H2A mitotic deubiquitination to ensure proper chromatin alignment and segregation during the mitotic phase [ xref , xref ]."
36980227
sparser
"Collectively, our results strongly suggest that CDK1 promotes the interaction between Plk1 and Usp16 and enhances the phosphorylation of Usp16 by Plk1."
26323689
reach
"Recently, CDK1 dependent phosphorylation of Usp16 on S552 was shown to promote an interaction between Usp16 and Plk1."
28380042
sparser
"Because Usp16 is phosphorylated by CDK1 ( xref ; xref ), we speculated that CDK1 might serve as a priming kinase regulating Plk1–Usp16 interaction in a way similar to other cases ( xref ; xref )."
26323689
sparser
"To identify any deubiquitylases that may deubiquitinate Plk1 in early mitosis, we performed reciprocal coimmunoprecipitation (coIP) assays and found that Usp16 specifically interacted with Plk1 in nocodazole-arrested prometaphase HeLa cells ( xref )."
26323689
reach
"To identify any deubiquitylases that may deubiquitinate Plk1 in early mitosis, we performed reciprocal coimmunoprecipitation (coIP) assays and found that Usp16 specifically interacted with Plk1 in nocodazole arrested prometaphase HeLa cells (XREF_FIG)."
26323689
biogrid
No evidence text available
26323689
reach
"Examination of the GST pull-down complexes showed that Usp16 specifically interacted with the wild-type (WT) PBD but not the PBD2A mutant (XREF_FIG), indicating that the interaction between Plk1 and Usp16 is PBD dependent."
26323689
reach
"Because Usp16 interacts with Plk1, we suspected that it might deubiquitinate Plk1."
26323689
PLK1 activates USP16.
4 | 2 5
PLK1 activates USP16. 10 / 15
4 | 2 5
signor
"In this study, we show that ubiquitin-specific peptidase 16 (Usp16) is a novel substrate for Plk1, and sequential phosphorylation by CDK1 and Plk1 activates Usp16, which, in turn, deubiquitinates Plk1 and promotes the recruitment of Plk1 to, and its retention on, the kinetochores for proper chromosome alignment.|In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig."
26323689
sparser
"These results strongly suggest that Plk1 phosphorylates and activates Usp16, but the exact molecular mechanism of the activation is not clear at the moment."
26323689
reach
"Because Usp16 deubiquitinates Plk1, we wondered whether Plk1 mediated Usp16 activation would also enhance the deubiquitination of Plk1 itself."
26323689
reach
"These results suggest that Plk1 activates Usp16, which, in turn, deubiquitinates Plk1 itself."
26323689
sparser
"Plk1 phosphorylates and activates Usp16."
26323689
sparser
"We found that the level of ubiquitinated histone H2A (ubH2A) was high in interphase and low in mitotic HeLa cells (Fig. S3, C–E), suggesting that Plk1 phosphorylates and activates Usp16."
26323689
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
sparser
"CDK1 and Plk1 sequentially phosphorylate and activate Usp16, which in turn deubiquitinates Plk1 to maintain the kinase’s kinetochore localization and promote proper chromosome alignment in mitosis."
26323689
USP16 affects PLK1
4 1 | 17 8
USP16 binds PLK1.
4 | 6 8
PLK1 binds USP16. 10 / 21
4 | 6 8
reach
"Usp16 interacts with and deubiquitinates Plk1."
26323689
sparser
"The regulated interaction between USP16 and PLK1 kinetochores may cooperate with its regulation on global H2A mitotic deubiquitination to ensure proper chromatin alignment and segregation during the mitotic phase [ xref , xref ]."
36980227
sparser
"Collectively, our results strongly suggest that CDK1 promotes the interaction between Plk1 and Usp16 and enhances the phosphorylation of Usp16 by Plk1."
26323689
reach
"Recently, CDK1 dependent phosphorylation of Usp16 on S552 was shown to promote an interaction between Usp16 and Plk1."
28380042
sparser
"Because Usp16 is phosphorylated by CDK1 ( xref ; xref ), we speculated that CDK1 might serve as a priming kinase regulating Plk1–Usp16 interaction in a way similar to other cases ( xref ; xref )."
26323689
sparser
"To identify any deubiquitylases that may deubiquitinate Plk1 in early mitosis, we performed reciprocal coimmunoprecipitation (coIP) assays and found that Usp16 specifically interacted with Plk1 in nocodazole-arrested prometaphase HeLa cells ( xref )."
26323689
reach
"To identify any deubiquitylases that may deubiquitinate Plk1 in early mitosis, we performed reciprocal coimmunoprecipitation (coIP) assays and found that Usp16 specifically interacted with Plk1 in nocodazole arrested prometaphase HeLa cells (XREF_FIG)."
26323689
biogrid
No evidence text available
26323689
reach
"Examination of the GST pull-down complexes showed that Usp16 specifically interacted with the wild-type (WT) PBD but not the PBD2A mutant (XREF_FIG), indicating that the interaction between Plk1 and Usp16 is PBD dependent."
26323689
reach
"Because Usp16 interacts with Plk1, we suspected that it might deubiquitinate Plk1."
26323689
USP16 deubiquitinates PLK1.
1 | 8
USP16 deubiquitinates PLK1. 9 / 9
1 | 8
reach
"CDK1 and Plk1 sequentially phosphorylate and activate Usp16, which in turn deubiquitinates Plk1 to maintain the kinase 's kinetochore localization and promote proper chromosome alignment in mitosis."
26323689
reach
"Similarly, ubiquitin-specific peptidase 16 (USP16), which is also a PLK1 substrate, deubiquitinates PLK1 to enhance its interaction with BUBR1 and to prevent premature removal of PLK1 from kinetochore[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34454931
ubibrowser
"ubiquitinspecific peptidase 16 (<span class="match term0">Usp16</span>) was identified as a <span class="match term1">PLK1</span> interacting protein in a co-immunoprecipitation (co-IP) assay in a PBD-dependent manner"
28188342
reach
"In this study, we show that ubiquitin specific peptidase 16 (Usp16) is a novel substrate for Plk1, and sequential phosphorylation by CDK1 and Plk1 activates Usp16, which, in turn, deubiquitinates Plk1 and promotes the recruitment of Plk1 to, and its retention on, the kinetochores for proper chromosome alignment."
26323689
reach
"Usp16 interacts with and deubiquitinates Plk1."
26323689
reach
"When Usp16 was knocked down by siRNA, we found that the ladder pattern bands above the main Plk1 band were enhanced, confirming our previous speculation that Usp16 might deubiquitinate Plk1 (XREF_FIG)."
26323689
reach
"Collectively, these results suggest that Plk1 is ubiquitinated by CUL3 based ubiquitin ligase in vivo, and the ubiquitination of Plk1 could be reversed by Usp16, which interacts with Plk1 in a PBD dependent manner in early mitosis."
26323689
reach
"Ubiquitin-specific peptidase 16 (Usp16) antagonizes the activity of CUL-3-based ubiquitin ligase by deubiquitinating PLK1 at the kinetochore [94]."
35563642
reach
"Because Usp16 deubiquitinates Plk1, we wondered whether Plk1 mediated Usp16 activation would also enhance the deubiquitination of Plk1 itself."
26323689
USP16 increases the amount of PLK1.
| 3
USP16 increases the amount of PLK1. 3 / 3
| 3
reach
"We found that, whereas the kinetochore localization of BubR1 was unchanged in both the control and Usp16 knockdown HeLa cells, knockdown of Usp16 in the cells reduced the amount of Plk1 localized on the kinetochores (XREF_FIG) and the binding between Plk1 and BubR1 (XREF_FIG)."
26323689
reach
"Because the kinetochore localization of Plk1 is necessary for kinetochore-microtubule attachment and subsequent chromosome alignment, we speculated that suppression of Usp16, i.e., reducing the amount of Plk1 on the kinetochores, would delay the chromosome alignment and anaphase onset."
26323689
reach
"It was found that the WT and 3E, but not 3A, Usp16 could restore the level of kinetochore localized Plk1, which was initially reduced by Usp16 knockdown (XREF_FIG)."
26323689
CDK1 affects USP16
1 2 3 1 | 5 6 9
CDK1 phosphorylates USP16.
1 1 | 4 5 9
CDK1 phosphorylates USP16. 10 / 12
| 3 4 5
rlimsp
"Because Usp16 is phosphorylated by CDK1 (Cai et al., 1999; Xu et al., 2013), we speculated that CDK1 might serve as a priming kinase regulating Plk1–Usp16 interaction in a way similar to other cases (Liu and Maller, 2005; Zhang et al., 2009)."
26323689
rlimsp
"To investigate this, we first set out to identify CDK1 phosphorylation sites on Usp16."
26323689
sparser
"Cdk1 phosphorylates Usp16 and enhances its binding to Plk1."
26323689
rlimsp
"Cdk1 phosphorylates Usp16 and enhances its binding to Plk1."
26323689
sparser
"Because Usp16 is phosphorylated by CDK1 ( xref ; xref ), we speculated that CDK1 might serve as a priming kinase regulating Plk1–Usp16 interaction in a way similar to other cases ( xref ; xref )."
26323689
reach
"Cdk1 phosphorylates Usp16 and enhances its binding to Plk1."
26323689
reach
"Because Usp16 is phosphorylated by CDK1, we speculated that CDK1 might serve as a priming kinase regulating Plk1-Usp16 interaction in a way similar to other cases."
26323689
rlimsp
"Usp16 is phosphorylated by CDK1 and Plk1."
26323689
reach
"During the cell cycle, Ubp-M is sequentially phosphorylated and dephosphorylated, potentially by the cdc-2/cyclin B complex, which phosphorylates Ubp-M in vitro ( Cai et al., 1999 )."
18374642
rlimsp
"The diagram shows that in early mitosis, cytosolic and possibly kinetochore-localized Usp16 is phosphorylated by CDK1 to generate a binding motif for PBD."
26323689
CDK1 phosphorylates USP16 on S552. 7 / 7
1 1 | 1 1 3
biopax:phosphositeplus
No evidence text available
reach
"Recently, CDK1 dependent phosphorylation of Usp16 on S552 was shown to promote an interaction between Usp16 and Plk1."
28380042
rlimsp
"To investigate this, we first set out to identify CDK1 phosphorylation sites on Usp16. By incubating GST-tagged Usp16 fragments, aa 1–150, aa 150–600, or aa 600–end individually with CDK1, we identified aa 150–600 as the only fragment being phosphorylated in vitro (Fig. 3 A). Sequence analysis revealed that S189 and S552 were potential phosphorylation sites for CDK1 (Fig. S2 A). Further analyses by in vitro phosphorylation assay and MS of peptides derived from proteins isolated from HeLa cells showed that S552 was the CDK1 phosphorylation site (Fig. S2, B and E), which was also reported recently (Xu et al., 2013). Next, we treated HeLa cells with CDK1 inhibitor RO3306 and observed a significant reduction in Plk1–Usp16 interaction (Fig. 3, C and E). Moreover, we found that only the WT GFP-Usp16, but not GFP-Usp16 S552A, could be coimmunoprecipitated with Plk1 from HeLa cell lysates (Fig. 3, D and F). These data strongly suggest that the phosphorylation of S552 by CDK1 promotes Plk1–Usp16 interaction."
26323689
rlimsp
"To investigate this, we first set out to identify CDK1 phosphorylation sites on Usp16. By incubating GST-tagged Usp16 fragments, aa 1–150, aa 150–600, or aa 600–end individually with CDK1, we identified aa 150–600 as the only fragment being phosphorylated in vitro (Fig. 3 A). Sequence analysis revealed that S189 and S552 were potential phosphorylation sites for CDK1 (Fig. S2 A). Further analyses by in vitro phosphorylation assay and MS of peptides derived from proteins isolated from HeLa cells showed that S552 was the CDK1 phosphorylation site (Fig."
26323689
sparser
"During mitosis, cyclin-dependent kinase 1 (Cdk1) phosphorylates USP16 at Ser552 and regulates its nuclear import by the exportin chromosome region maintenance 1 (Crm1) ( xref , xref )."
38462164
signor
"Here, we report that cyclin-dependent kinase 1 (cdk1) phosphorylates the histone h2a deubiquitinase ubp-m at serine 552 (s552p), and, importantly, this phosphorylation is required for cell cycle progression."
24013421
rlimsp
"Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression."
24013421
CDK1 phosphorylates USP16 on S189. 1 / 1
| 1
rlimsp
"To investigate this, we first set out to identify CDK1 phosphorylation sites on Usp16. By incubating GST-tagged Usp16 fragments, aa 1–150, aa 150–600, or aa 600–end individually with CDK1, we identified aa 150–600 as the only fragment being phosphorylated in vitro (Fig. 3 A). Sequence analysis revealed that S189 and S552 were potential phosphorylation sites for CDK1 (Fig."
26323689
CDK1 activates USP16.
1 | 1
CDK1 activates USP16. 2 / 5
1 | 1
signor
"Here, we report that cyclin-dependent kinase 1 (cdk1) phosphorylates the histone h2a deubiquitinase ubp-m at serine 552 (s552p), and, importantly, this phosphorylation is required for cell cycle progression."
24013421
sparser
"CDK1 and Plk1 sequentially phosphorylate and activate Usp16, which in turn deubiquitinates Plk1 to maintain the kinase’s kinetochore localization and promote proper chromosome alignment in mitosis."
26323689
CDK1 binds USP16.
3 1 |
CDK1 binds USP16. 4 / 4
3 1 |
biogrid
No evidence text available
24013421
biogrid
No evidence text available
26323689
biogrid
No evidence text available
10077596
hprd
No evidence text available
10077596
CDK1 dephosphorylates USP16.
| 1
CDK1 leads to the dephosphorylation of USP16. 1 / 1
| 1
reach
"During the cell cycle, Ubp-M is sequentially phosphorylated and dephosphorylated, potentially by the cdc-2/cyclin B complex, which phosphorylates Ubp-M in vitro ( Cai et al., 1999 )."
18374642
USP16 affects SKIL
| 28
USP16 binds SKIL. 10 / 28
| 28
sparser
"These findings suggest that SNO-USP16 at the C731 site is involved in CME-induced GSH imbalance."
41339351
sparser
"Therefore, SNO-USP16 could facilitate the ubiquitination and degradation of KDM1A in CME."
41339351
sparser
"Moreover, the enhanced SNO-USP16 levels in the CME model were lowered by infection with AAV9-USP16-WT, which was more apparent in the AAV9-USP16-C731A infection group (Fig.  xref )."
41339351
sparser
"SNO-USP16 at the C731 site facilitates KDM1A ubiquitination."
41339351
sparser
"Therefore, SNO-USP16 was predicted to play a role in the pathogenesis of CME."
41339351
sparser
"In the present study, we provide evidence that iNOS contributes to SNO-USP16 at the C731 site and subsequently results in KDM1A protein ubiquitination, thus leading to a GSH imbalance under hypoxic conditions."
41339351
sparser
"Given that SNO-USP16 contributed to GSH imbalance during CME, we further elucidated whether SNO-USP16 could affect KDM1A protein ubiquitination."
41339351
sparser
"These findings prove that iNOS-mediated SNO-USP16 promotes CME progression."
41339351
sparser
"In conclusion, our results confirmed that iNOS-mediated SNO-USP16 served as a driver of ubiquitination and degradation of KDM1A protein, which disrupted GSH homeostasis and exacerbated CME-induced myocardial injury (Fig.  xref )."
41339351
sparser
"Thus, inhibition of SNO-USP16 at the C731 site suppresses the ubiquitination and degradation of KDM1A."
41339351
USP16 affects MYC
3 1 | 10 3
USP16 binds MYC.
3 | 2 3
MYC binds USP16. 7 / 7
3 | 2 2
reach
"The interaction between endogenous c-Myc and USP16 was also demonstrated in PC3 cells."
33546726
reach
"To further assess the association between USP16 and c-Myc in PCa, we detected the expression of USP16 and c-Myc using tissue microarrays containing 82 human PCa tissues."
33546726
biogrid
No evidence text available
29467282
biogrid
No evidence text available
33546726
biogrid
No evidence text available
33546726
sparser
"The interaction between USP16 and c-Myc protein was assessed by co-immunoprecipitation and protein co-localization assays."
33546726
sparser
"The interaction between endogenous c-Myc and USP16 was also demonstrated in PC3 cells (Fig. xref e)."
33546726
USP16 binds MYC and Flag. 1 / 1
| 1
sparser
"To identify whether USP16 serves as a DUB of c-Myc, HEK293T cells were transfected with plasmids encoding HA-ubiquitin and Flag-c-Myc with wild-type USP16 or its catalytically inactive mutant USP16-C205S and treated with MG132."
33546726
USP16 activates MYC.
| 4
USP16 activates MYC. 2 / 2
| 2
reach
"We found that knockdown of USP16 dramatically reduced c-Myc protein abundance but did not affect its mRNA levels, suggesting that the regulation of c-Myc by USP16 occurs at the post-transcriptional level."
33546726
reach
"We found that ectopic expression of USP16 enhanced the stability of c-Myc protein, while USP16 knockdown reduced the half-life of c-Myc protein."
33546726
USP16 activates MYC. 2 / 2
| 2
reach
"In addition, knockdown of USP16 significantly reduced c-Myc abundance at the post-translational level, while overexpression of wild-type USP16, instead of its catalytic inactive mutant (C205S) [XREF_BIBR], stabilized c-Myc."
33546726
reach
"Analysis of c-Myc protein levels by Western blot revealed that knockdown of USP16 significantly decreased the abundance of c-Myc."
33546726
USP16 deubiquitinates MYC.
1 | 2
USP16 deubiquitinates MYC. 3 / 3
1 | 2
reach
"Besides, the knockdown of USP16 significantly enhanced the polyubiquitination of c-Myc."
33546726
ubibrowser
"<span class="match term0">USP16</span> regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-<span class="match term1">Myc</span>"
33546726
reach
"USP16 deubiquitinates c-Myc."
33546726
USP16 ubiquitinates MYC.
| 1
USP16 leads to the ubiquitination of MYC. 1 / 1
| 1
reach
"XREF_FIG g, the wild-type USP16, but not USP16-C205S, markedly reduced the ubiquitination of c-Myc."
33546726
USP16 decreases the amount of MYC.
| 1
USP16 decreases the amount of MYC. 1 / 1
| 1
reach
"In the present study, we found that the targeted disruption of USP16, but not other deubiquitinases of c-Myc, reduced c-Myc protein levels in PCa, indicating that DUBs have different functions in different cancers."
33546726
USP16 affects IKBKB
| 10 7
USP16 binds IKBKB.
| 7 7
IKBKB binds USP16. 10 / 11
| 7 4
reach
"By comparison with NEMO, we identified five conserved amino acids that are important for binding between USP16 and IKKbeta, as suggested by the disappearance of the signal upon deletion of the sequence (XREF_FIG)."
| PMC
sparser
"Co-IP indicated that the UBP14 domain is indispensable for USP16 binding to IKKβ ( xref )."
| PMC
sparser
"To further confirm the interaction between endogenous USP16 and IKKβ, we generated USP16 fl mice and crossed them with Lyz2 -Cre mice to delete USP16 in myeloid cells, producing myeloid cell–specific USP16-KO (USP16 MKO ) mice (fig."
| PMC
sparser
"The co-IP results revealed continuous interaction between endogenous USP16 and IKKβ in BMDMs, and LPS stimulation did not promote or suppress this association ( xref )."
| PMC
reach
"USP16 selectively interacts with IKKbeta and IKKalpha."
| PMC
reach
"Under TNF-alpha stimulation, coimmunoprecipitation (co-IP) assays demonstrated that USP16 physically associated with IKKbeta but not with p105 or IkappaBalpha in cotransfected HEK293T cells (XREF_FIG)."
| PMC
reach
"To further confirm the interaction between endogenous USP16 and IKKbeta, we generated USP16 fl mice and crossed them with Lyz2-Cre mice to delete USP16 in myeloid cells, producing myeloid cell specific USP16-KO (USP16 MKO) mice."
| PMC
reach
"In transfected HEK293T cells, the results of co-IP revealed that the association between IKKbeta and USP16 was dependent on the NBD of IKKbeta (XREF_FIG)."
| PMC
sparser
"Under TNF-α stimulation, coimmunoprecipitation (co-IP) assays demonstrated that USP16 physically associated with IKKβ but not with p105 or IκBα in cotransfected HEK293T cells ( xref )."
| PMC
reach
"Depletion of the NBD disrupted the interaction of USP16 with both IKKbeta and IKKalpha (XREF_FIG), which further suggests that USP16 and NEMO may competitively bind to IKKbeta and IKKalpha."
| PMC
USP16 binds IKBKB and CHUK. 2 / 2
| 2
sparser
"USP16 selectively interacts with IKKβ and IKKα."
| PMC
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
USP16 ubiquitinates IKBKB.
| 1
USP16 leads to the ubiquitination of IKBKB. 1 / 1
| 1
reach
"These data establish USP16 and USP16 mediated IKKbeta ubiquitination as a novel regulatory mechanism of NF-kappaB signaling and intestinal tumorigenesis and suggest an important role of USP16 in colitis related CRC pathogenesis."
| PMC
USP16 phosphorylates IKBKB.
| 1
USP16 leads to the phosphorylation of IKBKB. 1 / 1
| 1
reach
"This observation raised a critical question regarding whether USP16 directly regulates IKKbeta activity or p105 phosphorylation."
| PMC
USP16 activates IKBKB.
| 1
USP16 activates IKBKB. 1 / 1
| 1
reach
"USP16 mediated DUB of IKKbeta directly, while the USP16 CI mutant lost its ability to regulate IKKbeta ubiquitination, as suggested by in vitro DUB assays (XREF_FIG)."
| PMC
TTK affects USP16
3 4 1 | 4 4
TTK phosphorylates USP16.
3 2 | 4 4
TTK phosphorylates USP16. 6 / 6
| 3 3
reach
"TTK dependent phosphorylation of Usp16 causes protein degradation."
28380042
rlimsp
"These results indicate that Usp16 is directly phosphorylated by TTK in vitro."
28380042
rlimsp
"We next sought to identify the TTK dependent phosphorylation sites on Usp16 by performing mass spectrometry."
28380042
reach
"We also found that TTK phosphorylates and regulates the protein stability of Usp16, an enzyme required to promote chromosomal condensation, suggesting that TTK functions at multiple stages of the cell cycle to maintain genome stability."
28380042
reach
"These results indicate that Usp16 is directly phosphorylated by TTK in vitro."
28380042
rlimsp
"We also found that TTK phosphorylates and regulates the protein stability of Usp16, an enzyme required to promote chromosomal condensation, suggesting that TTK functions at multiple stages of the cell cycle to maintain genome stability."
28380042
TTK phosphorylates USP16 on S415. 3 / 3
1 1 | 1
rlimsp
"Analysis of the resulting spectra identified three TTK-dependent phosphorylation sites within Usp16: S415, S552, T554 (Fig 5B)."
28380042
biopax:phosphositeplus
No evidence text available
signor
"Usp16 is a TTK phosphorylation substrate."
28380042
TTK phosphorylates USP16 on T554. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"Usp16 is a TTK phosphorylation substrate."
28380042
TTK phosphorylates USP16 on S552. 2 / 2
1 | 1
biopax:phosphositeplus
No evidence text available
reach
"Future studies will be required to confirm whether TTK dependent phosphorylation of Usp16 S552 plays a similar role in regulating Plk1 to maintain proper SAC function."
28380042
TTK decreases the amount of USP16.
2 |
TTK decreases the amount of USP16. 2 / 2
2 |
signor
"Usp16 is a TTK phosphorylation substrate."
28380042
signor
"Usp16 is a TTK phosphorylation substrate."
28380042
TTK binds USP16.
1 |
TTK binds USP16. 1 / 1
1 |
biogrid
No evidence text available
28380042
HERC2 affects USP16
6 | 4 5
HERC2 binds USP16.
6 | 3 5
USP16 binds HERC2. 10 / 14
6 | 3 5
biogrid
No evidence text available
30279242
reach
"USP16 interacts with HERC2 and modulates the ubiquitination in DNA repair machinery components."
28018215
biogrid
No evidence text available
28514442
sparser
"Here we report that the histone H2A deubiquitinase USP16 interacts with HERC2, fine-tunes the ubiquitin signal during repair, and importantly, is required for terminating the ubiquitination signal after repair."
25305019
reach
"Here we report that the histone H2A deubiquitinase USP16 interacts with HERC2, fine-tunes the ubiquitin signal during repair, and importantly, is required for terminating the ubiquitination signal after repair."
25305019
biogrid
No evidence text available
33961781
sparser
"This mechanism may explain the evolution of the USP16-HERC2 interaction ( xref , xref , xref online): the USP16 coil-coiled interaction domain at ∼200 a."
28177072
sparser
"HERC2 interacts with the coiled-coil domain of USP16 through its C-terminal HECT domain."
25305019
biogrid
No evidence text available
19615732
sparser
"Furthermore, HERC2 interacts with the disordered region of USP16 (residues 136–185) through its C-terminal HECT domain (residues 4421–4834), increasing the intracellular expression of USP16 [ xref ]."
39996778
HERC2 increases the amount of USP16.
| 1
HERC2 increases the amount of USP16. 1 / 1
| 1
reach
"In response to DNA damage, the HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2)-dependent increase in the level of USP16 negatively regulates ubiquitin foci formation by H2AK119Ub and K15Ub."
| PMC
USP16 affects NFKB1
| 1 7 6
USP16 phosphorylates NFKB1.
| 5 6
USP16 leads to the phosphorylation of NFKB1. 10 / 11
| 5 6
reach
"This observation raised a critical question regarding whether USP16 directly regulates IKKbeta activity or p105 phosphorylation."
| PMC
sparser
"USP16 specifically promotes p105 phosphorylation."
| PMC
reach
"USP16 specifically promotes p105 phosphorylation."
| PMC
reach
"In these reconstituted USP16 -/- fibroblasts, USP16 WT, but not USP16 CI, rescued the phosphorylation of p105 and the interaction between IKKbeta and p105 (XREF_FIG)."
| PMC
reach
"With IKKbeta K238R, USP16 silencing no longer impaired the phosphorylation of p105."
| PMC
sparser
"The deubiquitinating enzyme USP16 can promote the interaction between IKKβ and p105 and phosphorylate p105 by selectively removing K33-linked polyubiquitin chains from IKKβ, thereby activating the NF-κB signaling pathway and promoting intestinal inflammation [ xref ]."
39420190
sparser
"The deubiquitinating enzyme USP16 can promote the interaction between IKKβ and p105 and phosphorylate p105 by selectively removing K33-linked polyubiquitin chains from IKKβ, thereby activating the NF-κB signaling pathway and promoting intestinal inflammation [ xref ]."
39420190
sparser
"The deubiquitinating enzyme USP16 can promote the interaction between IKKβ and p105 and phosphorylate p105 by selectively removing K33-linked polyubiquitin chains from IKKβ, thereby activating the NF-κB signaling pathway and promoting intestinal inflammation [ xref ]."
39420190
reach
"Collectively, these data indicated that the USP16 mediated deubiquitination of IKKbeta may be specifically involved in the phosphorylation and processing of p105."
| PMC
sparser
"USP16 specifically promotes p105 phosphorylation."
| PMC
USP16 inhibits NFKB1.
| 2
USP16 inhibits NFKB1. 2 / 2
| 2
reach
"We further demonstrated that loss of USP16 specifically causes inactivation of p105 in both BMDMs and MEFs, as indicated by low phosphorylation levels of p105 and low nuclear translocation of p50."
| PMC
reach
"USP16 deficiency strongly inhibited the activation of p105 by the typical IKK complex under LPS stimulation, as revealed by an in vitro kinase assay (XREF_FIG)."
| PMC
USP16 activates NFKB1.
| 1
USP16 activates NFKB1. 1 / 1
| 1
eidos
"We further demonstrated that loss of USP16 specifically causes inactivation of p105 in both BMDMs and MEFs , as indicated by low phosphorylation levels of p105 and low nuclear translocation of p50 ."
| PMC
USP16 affects HERC2
6 | 3 5
USP16 binds HERC2. 10 / 14
6 | 3 5
biogrid
No evidence text available
30279242
reach
"USP16 interacts with HERC2 and modulates the ubiquitination in DNA repair machinery components."
28018215
biogrid
No evidence text available
28514442
sparser
"Here we report that the histone H2A deubiquitinase USP16 interacts with HERC2, fine-tunes the ubiquitin signal during repair, and importantly, is required for terminating the ubiquitination signal after repair."
25305019
reach
"Here we report that the histone H2A deubiquitinase USP16 interacts with HERC2, fine-tunes the ubiquitin signal during repair, and importantly, is required for terminating the ubiquitination signal after repair."
25305019
biogrid
No evidence text available
33961781
sparser
"This mechanism may explain the evolution of the USP16-HERC2 interaction ( xref , xref , xref online): the USP16 coil-coiled interaction domain at ∼200 a."
28177072
sparser
"HERC2 interacts with the coiled-coil domain of USP16 through its C-terminal HECT domain."
25305019
biogrid
No evidence text available
19615732
sparser
"Furthermore, HERC2 interacts with the disordered region of USP16 (residues 136–185) through its C-terminal HECT domain (residues 4421–4834), increasing the intracellular expression of USP16 [ xref ]."
39996778
IKBKB affects USP16
| 7 7
IKBKB binds USP16. 10 / 11
| 7 4
reach
"By comparison with NEMO, we identified five conserved amino acids that are important for binding between USP16 and IKKbeta, as suggested by the disappearance of the signal upon deletion of the sequence (XREF_FIG)."
| PMC
sparser
"Co-IP indicated that the UBP14 domain is indispensable for USP16 binding to IKKβ ( xref )."
| PMC
sparser
"To further confirm the interaction between endogenous USP16 and IKKβ, we generated USP16 fl mice and crossed them with Lyz2 -Cre mice to delete USP16 in myeloid cells, producing myeloid cell–specific USP16-KO (USP16 MKO ) mice (fig."
| PMC
sparser
"The co-IP results revealed continuous interaction between endogenous USP16 and IKKβ in BMDMs, and LPS stimulation did not promote or suppress this association ( xref )."
| PMC
reach
"USP16 selectively interacts with IKKbeta and IKKalpha."
| PMC
reach
"Under TNF-alpha stimulation, coimmunoprecipitation (co-IP) assays demonstrated that USP16 physically associated with IKKbeta but not with p105 or IkappaBalpha in cotransfected HEK293T cells (XREF_FIG)."
| PMC
reach
"To further confirm the interaction between endogenous USP16 and IKKbeta, we generated USP16 fl mice and crossed them with Lyz2-Cre mice to delete USP16 in myeloid cells, producing myeloid cell specific USP16-KO (USP16 MKO) mice."
| PMC
reach
"In transfected HEK293T cells, the results of co-IP revealed that the association between IKKbeta and USP16 was dependent on the NBD of IKKbeta (XREF_FIG)."
| PMC
sparser
"Under TNF-α stimulation, coimmunoprecipitation (co-IP) assays demonstrated that USP16 physically associated with IKKβ but not with p105 or IκBα in cotransfected HEK293T cells ( xref )."
| PMC
reach
"Depletion of the NBD disrupted the interaction of USP16 with both IKKbeta and IKKalpha (XREF_FIG), which further suggests that USP16 and NEMO may competitively bind to IKKbeta and IKKalpha."
| PMC
USP16 binds IKBKB and CHUK. 2 / 2
| 2
sparser
"USP16 selectively interacts with IKKβ and IKKα."
| PMC
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
MYC affects USP16
3 | 5 3
MYC binds USP16.
3 | 2 3
MYC binds USP16. 7 / 7
3 | 2 2
reach
"The interaction between endogenous c-Myc and USP16 was also demonstrated in PC3 cells."
33546726
reach
"To further assess the association between USP16 and c-Myc in PCa, we detected the expression of USP16 and c-Myc using tissue microarrays containing 82 human PCa tissues."
33546726
biogrid
No evidence text available
29467282
biogrid
No evidence text available
33546726
biogrid
No evidence text available
33546726
sparser
"The interaction between USP16 and c-Myc protein was assessed by co-immunoprecipitation and protein co-localization assays."
33546726
sparser
"The interaction between endogenous c-Myc and USP16 was also demonstrated in PC3 cells (Fig. xref e)."
33546726
USP16 binds MYC and Flag. 1 / 1
| 1
sparser
"To identify whether USP16 serves as a DUB of c-Myc, HEK293T cells were transfected with plasmids encoding HA-ubiquitin and Flag-c-Myc with wild-type USP16 or its catalytically inactive mutant USP16-C205S and treated with MG132."
33546726
MYC inhibits USP16.
| 1
MYC inhibits USP16. 1 / 1
| 1
reach
"Co-immunoprecipitation and ubiquitination assays confirmed that USP16 served as a novel deubiquitinase of c-Myc and overexpression of c-Myc significantly rescued the effects of USP16 disruption."
33546726
MYC increases the amount of USP16.
| 1
MYC increases the amount of USP16. 1 / 1
| 1
reach
"Besides, it remains to explore whether c-Myc signalling could activate USP16 expression, resulting in a positive feedback loop that further promotes tumourigenesis."
33546726
MYC activates USP16.
| 1
MYC activates USP16. 1 / 1
| 1
reach
"Moreover, c-Myc overexpression restored the proliferation and colony formation abilities of USP16 silenced cells."
33546726
USP16 affects UBC
10 |
USP16 binds UBC. 10 / 10
10 |
biogrid
No evidence text available
17512543
biogrid
No evidence text available
29576527
biogrid
No evidence text available
33141564
biogrid
No evidence text available
23287719
biogrid
No evidence text available
28190767
biogrid
No evidence text available
34642328
biogrid
No evidence text available
34642328
biogrid
No evidence text available
15171253
biogrid
No evidence text available
32110315
biogrid
No evidence text available
22195557
USP16
7 1 | 1
USP16 is active.
5 |
USP16 phosphorylated on S486 is active. 2 / 2
2 |
signor
"In this study, we show that ubiquitin-specific peptidase 16 (Usp16) is a novel substrate for Plk1, and sequential phosphorylation by CDK1 and Plk1 activates Usp16, which, in turn, deubiquitinates Plk1 and promotes the recruitment of Plk1 to, and its retention on, the kinetochores for proper chromosome alignment.|In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig."
26323689
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
USP16 phosphorylated on S330 is active. 1 / 1
1 |
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
USP16 phosphorylated on S552 is active. 1 / 1
1 |
signor
"Here, we report that cyclin-dependent kinase 1 (cdk1) phosphorylates the histone h2a deubiquitinase ubp-m at serine 552 (s552p), and, importantly, this phosphorylation is required for cell cycle progression."
24013421
USP16 phosphorylated on S386 is active. 1 / 1
1 |
signor
"Plk1 phosphorylates and activates Usp16. In vitro phosphorylation of Usp16 with single (S330A, S386A, or S486A) or collective 3A (S330A/S386A/S486A) mutation showed that Plk1 phosphorylated Usp16 at all three sites (Fig. S2 D)."
26323689
USP16 is inactive.
2 |
USP16 phosphorylated on T554 is inactive. 1 / 1
1 |
signor
"Usp16 is a TTK phosphorylation substrate."
28380042
USP16 phosphorylated on S415 is inactive. 1 / 1
1 |
signor
"Usp16 is a TTK phosphorylation substrate."
28380042
USP16 translocates.
| 1
USP16 translocates from the nucleus to the cytoplasm. 1 / 1
| 1
sparser
"Whereby, following mitosis, USP16 is rapidly exported from the nucleus to the cytoplasm."
36980227
USP16 binds.
1 |
USP16 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
24013421
USP16 affects IGF2BP3
4 | 5
IGF2BP3 binds USP16. 9 / 9
4 | 5
sparser
"MNX1-AS1 serves as a scaffold for IGF2BP3 and USP16 (ubiquitin specific peptidase 16) interaction, leading to IGF2BP2 de-ubiquitination and stabilization [ 133 ]."
37690652
sparser
"Therefore, we explored whether MNX1-AS1 was required for the interaction between IGF2BP3 and USP16."
35953000
sparser
"The specific interaction of IGF2BP3 and USP16 was confirmed by Co-IP followed by western blotting ( Fig. 5 B), and the results of RNA-pull-down and RIP assays demonstrated that there was an interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35953000
sparser
"The results demonstrated that the interaction between IGF2BP3 and USP16 could be abolished by ribonuclease (RNase) treatment ( Fig. 5 F) and MNX1-AS1 silencing ( Fig. 5 G)."
35953000
sparser
"To address the role of MNX1-AS1 in gallbladder cancer, it was found to enhance the binding of IGF2BP3 (Insulin-like growing factor 2 mRNA-binding protein 3) to USP16 [ xref ] ( xref H)."
36980227
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35953000
biogrid
No evidence text available
35953000
biogrid
No evidence text available
35953000
USP16 affects Flag
| 9
USP16 binds Flag. 8 / 8
| 8
sparser
"To test this, we transfected Flag-USP16 or the 2A mutant into HeLa cells and isolated USP16 by Flag IP."
38462164
sparser
"For this purpose, we cotransfected HeLa cells with Myc-OGT and Flag-USP16 and performed co-immunoprecipitation (co-IP) assays with the anti-Flag antibody ( xref A )."
38462164
sparser
"Labelling experiments were performed with HeLa cells lysate overexpressing Flag-USP5, Flag-USP7, Flag-USP15 or Flag-USP16 and their catalytically inactive versions ( xref )."
32110315
sparser
"In xref , it is shown that only Flag-USP16 reacts with M20, while all the other DUBs are labelled only by the wild-type probe."
32110315
sparser
"First, we transfected Flag-USP16, HA-Ub, and Myc-OGT into the cells ( xref A ) and used Noc to synchronize them into the M phase."
38462164
sparser
"To determine whether the change in the subcellular localization of USP16 is due to impaired interaction with Crm1, we transfected HeLa cells with Flag-USP16 and HA-Crm1."
38462164
sparser
"The interaction was also confirmed by revealing that GST-OGT, but not GST itself, pulled down Flag-USP16 expressed in HeLa cells ( xref D )."
38462164
sparser
"Furthermore, USP16 protein was detected when Flag-c-Myc was immunoprecipitated by Flag antibody, and inversely c-Myc was detected when Flag-USP16 was immunoprecipitated in PC3 cells (Fig. xref c and d)."
33546726
USP16 binds MYC and Flag. 1 / 1
| 1
sparser
"To identify whether USP16 serves as a DUB of c-Myc, HEK293T cells were transfected with plasmids encoding HA-ubiquitin and Flag-c-Myc with wild-type USP16 or its catalytically inactive mutant USP16-C205S and treated with MG132."
33546726
IGF2BP3 affects USP16
4 | 5
IGF2BP3 binds USP16. 9 / 9
4 | 5
sparser
"MNX1-AS1 serves as a scaffold for IGF2BP3 and USP16 (ubiquitin specific peptidase 16) interaction, leading to IGF2BP2 de-ubiquitination and stabilization [ 133 ]."
37690652
sparser
"Therefore, we explored whether MNX1-AS1 was required for the interaction between IGF2BP3 and USP16."
35953000
sparser
"The specific interaction of IGF2BP3 and USP16 was confirmed by Co-IP followed by western blotting ( Fig. 5 B), and the results of RNA-pull-down and RIP assays demonstrated that there was an interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35953000
sparser
"The results demonstrated that the interaction between IGF2BP3 and USP16 could be abolished by ribonuclease (RNase) treatment ( Fig. 5 F) and MNX1-AS1 silencing ( Fig. 5 G)."
35953000
sparser
"To address the role of MNX1-AS1 in gallbladder cancer, it was found to enhance the binding of IGF2BP3 (Insulin-like growing factor 2 mRNA-binding protein 3) to USP16 [ xref ] ( xref H)."
36980227
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35953000
biogrid
No evidence text available
35953000
biogrid
No evidence text available
35953000
Flag affects USP16
| 9
USP16 binds Flag. 8 / 8
| 8
sparser
"To test this, we transfected Flag-USP16 or the 2A mutant into HeLa cells and isolated USP16 by Flag IP."
38462164
sparser
"For this purpose, we cotransfected HeLa cells with Myc-OGT and Flag-USP16 and performed co-immunoprecipitation (co-IP) assays with the anti-Flag antibody ( xref A )."
38462164
sparser
"Labelling experiments were performed with HeLa cells lysate overexpressing Flag-USP5, Flag-USP7, Flag-USP15 or Flag-USP16 and their catalytically inactive versions ( xref )."
32110315
sparser
"In xref , it is shown that only Flag-USP16 reacts with M20, while all the other DUBs are labelled only by the wild-type probe."
32110315
sparser
"First, we transfected Flag-USP16, HA-Ub, and Myc-OGT into the cells ( xref A ) and used Noc to synchronize them into the M phase."
38462164
sparser
"To determine whether the change in the subcellular localization of USP16 is due to impaired interaction with Crm1, we transfected HeLa cells with Flag-USP16 and HA-Crm1."
38462164
sparser
"The interaction was also confirmed by revealing that GST-OGT, but not GST itself, pulled down Flag-USP16 expressed in HeLa cells ( xref D )."
38462164
sparser
"Furthermore, USP16 protein was detected when Flag-c-Myc was immunoprecipitated by Flag antibody, and inversely c-Myc was detected when Flag-USP16 was immunoprecipitated in PC3 cells (Fig. xref c and d)."
33546726
USP16 binds MYC and Flag. 1 / 1
| 1
sparser
"To identify whether USP16 serves as a DUB of c-Myc, HEK293T cells were transfected with plasmids encoding HA-ubiquitin and Flag-c-Myc with wild-type USP16 or its catalytically inactive mutant USP16-C205S and treated with MG132."
33546726
USP16 affects CHUK
| 3 5
USP16 binds CHUK. 4 / 4
| 3 1
reach
"Unexpectedly, USP16 could also associate with IKKalpha, but no signal of its binding to NEMO was detected (XREF_FIG)."
| PMC
reach
"Depletion of the NBD disrupted the interaction of USP16 with both IKKbeta and IKKalpha (XREF_FIG), which further suggests that USP16 and NEMO may competitively bind to IKKbeta and IKKalpha."
| PMC
reach
"USP16 selectively interacts with IKKbeta and IKKalpha."
| PMC
sparser
"Unexpectedly, USP16 could also associate with IKKα, but no signal of its binding to NEMO was detected ( xref )."
| PMC
USP16 binds IKBKB and CHUK. 2 / 2
| 2
sparser
"USP16 selectively interacts with IKKβ and IKKα."
| PMC
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
CHUK binds IKBKG and USP16. 1 / 1
| 1
sparser
"IKKα and IKKβ contain similar functional domains; thus, we further evaluated the interaction of USP16 with IKKα and NEMO."
| PMC
USP16 affects oxalate(1-)
| 2 5
USP16 increases the amount of oxalate(1-).
| 2
USP16 increases the amount of oxalate(1-). 2 / 2
| 2
reach
"USP16 activates transcription of HOX genes in a manner consistent with reversing the repressive activity of the Polycomb complex."
21513801
reach
"It has also been demonstrated that Ubp-M regulates Hox gene expression by H2A deubiquitylation and Ubp-M is involved in posterior development of Xenopus laevis."
20685273
USP16 decreases the amount of oxalate(1-).
| 2
USP16 decreases the amount of oxalate(1-). 2 / 2
| 2
reach
"Knockdown of Usp16 causes a decrease in Hox expression and the rescue from this defect requires the deubiquitinating activity of Usp16."
19489724
reach
"Given that previous studies indicate that H2A ubiquitination regulates Hox gene silencing, it is possible that Usp16 may repress Hox gene expression by modulating the levels of uH2A at the promoter and 5 ' end regulatory region of the Hox gene Finally, there is recent evidence that, in addition to a role in silencing, uH2A may also control transcriptional initiation."
19489724
USP16 activates oxalate(1-).
| 1 1
USP16 activates oxalate(1-). 2 / 2
| 1 1
eidos
"Knockdown of Usp16 causes a decrease in Hox expression and the rescue from this defect requires the deubiquitinating activity of Usp16 ."
19489724
reach
"The in vivo relevance of Ubp-M mediated Hox gene activation was suggested by the observation that injection of Ubp-M antibodies in Xenopus embryos led to deregulation of HoxD10 expression and defects in posterior development."
18430235
USP16 inhibits oxalate(1-).
| 1
USP16 inhibits oxalate(1-). 1 / 1
| 1
eidos
"Given that previous studies indicate that H2A ubiquitination regulates Hox gene silencing , it is possible that Usp16 may repress Hox gene expression by modulating the levels of uH2A at the promoter and 5 ' end regulatory region of the Hox gene ( 83 , 153 , 174 , 175 ) Finally , there is recent evidence that , in addition to a role in silencing , uH2A may also control transcriptional initiation ."
19489724
USP16 affects CDKN2A
| 1 4 2
USP16 activates CDKN2A.
| 1 2 1
USP16 activates CDKN2A. 4 / 4
| 1 2 1
reach
"USP16 activates Cdkn2a, which acts as a negative regulator of the Wnt signalling pathway."
32962300
reach
"Modulation of Ink4a and Arf by Usp16 in Ts65Dn cells."
24025767
eidos
"USP16 activates Cdkn2a , which acts as a negative regulator of the Wnt signalling pathway ."
32962300
sparser
"USP16 activates Cdkn2a, which acts as a negative regulator of the Wnt signalling pathway."
32962300
USP16 increases the amount of CDKN2A.
| 1
Modified USP16 increases the amount of CDKN2A. 1 / 1
| 1
reach
"In Ts65Dn satellite cells, Usp16 expression is increased but we found no evidence of increased p16 Ink4a expression (data not shown)."
29523805
USP16 decreases the amount of CDKN2A.
| 1
USP16 decreases the amount of CDKN2A. 1 / 1
| 1
reach
"However, lentiviral downregulation of Usp16 with two different hairpins decreased p16 Ink4a and p19 Arf expression (XREF_FIG)."
24025767
USP16 binds CDKN2A.
| 1
USP16 binds CDKN2A. 1 / 1
| 1
sparser
"Moreover, Usp16 is associated with decreased ubiquitination of Cdkn2a and accelerated senescence in Ts65Dn fibroblasts."
24025767
USP16 affects ubH2A
| 1 5
USP16 inhibits ubH2A.
| 1 1
USP16 inhibits ubH2A. 2 / 2
| 1 1
eidos
"In contrast to observations in ESCs and HSCs , USP16 deficiency did not increase ubH2A levels ( fig ."
| PMC
reach
"When ESCs are differentiated, Usp16 is required to reverse ubH2A mediated gene repression and enables gene activation and subsequent ESC differentiation."
24784029
USP16 decreases the amount of ubH2A.
| 2
USP16 decreases the amount of ubH2A. 2 / 2
| 2
reach
"Joo and colleagues showed that Ubp-M deubiquitinates ubH2A within a nucleosome in vitro and that knockdown of Ubp-M increases ubH2A levels in vivo."
18374642
reach
"Supporting our biochemical assays, Usp16 knockout caused a significant increase of ubH2A levels without any apparent effects on H2A levels (XREF_FIG)."
24784029
USP16 increases the amount of ubH2A.
| 1
USP16 increases the amount of ubH2A. 1 / 1
| 1
reach
"In contrast to observations in ESCs and HSCs, USP16 deficiency did not increase ubH2A levels."
| PMC
USP16 deubiquitinates ubH2A.
| 1
USP16 deubiquitinates ubH2A. 1 / 1
| 1
reach
"Joo and colleagues showed that Ubp-M deubiquitinates ubH2A within a nucleosome in vitro and that knockdown of Ubp-M increases ubH2A levels in vivo."
18374642
USP16 affects ISG15
1 | 5
USP16 binds ISG15. 6 / 6
1 | 5
sparser
"When we compare the AF3 model of USP16 binding to ISG15 with our crystal structures of ISG15 bound to VHH ISG15-A or VHH ISG15-B , we would predict that only VHH ISG15-A would exhibit mutually exclusive binding because of a steric clash ( xref A )."
40774387
sparser
"It is therefore still unclear whether the ZnF domain of USP16 binds free ISG15 in the same mode as free Ub, and if it plays a regulatory role in ISG15-dependent processes in cells."
38055744
sparser
"Since our R153Agb mutant probes bind and interact with USP16 to some extent, our ongoing investigation also includes understanding the molecular interactions between ISG15 and USP16 that can help design more selective probes with increased affinity for USP18 and minimal or no cross-reactivity with USP16."
39843430
sparser
"Although a structure of the USP16–ISG15 complex remains to be determined, AF3 predicts that ISG15 interacts with USP16 at both N- and C-terminal domains ( xref A )."
40774387
sparser
"Compound 25 was shown to disrupt the wildtype HDAC6/ISG15 BRET signal in a dose-dependent manner to the same level as HDAC6 R1155A, Y1184A . To assess the selectivity of 25 in cells, a NanoBRET assay was designed to assess USP16-ISG15 interaction."
37499118
biogrid
No evidence text available
37499118
reach
"A deubiquitylation enzyme, USP16, negatively regulates uH2A dependent function and rapidly restores transcription after the cessation of DNA damage."
22649771
reach
"Similar data were obtained with three separate siRNAs directed against USP16, while expression of a siRNA resistant USP16 allele restored transcription after ATMi (XREF_SUPPLEMENTARY)."
20550933
sparser
"MYSM1 and USP16 activate transcription."
18226187
reach
"MYSM1 and USP16 activate transcription."
18226187
sparser
"USP16 activates transcription of HOX genes in a manner consistent with reversing the repressive activity of the Polycomb complex."
21513801
reach
"USP16 depletion could prevent ATMi mediated restoration of transcription, indicating that this DUB is responsible for de-ubiquitylation of uH2A at DSBs."
23847653
ISG15 affects USP16
1 | 5
USP16 binds ISG15. 6 / 6
1 | 5
sparser
"When we compare the AF3 model of USP16 binding to ISG15 with our crystal structures of ISG15 bound to VHH ISG15-A or VHH ISG15-B , we would predict that only VHH ISG15-A would exhibit mutually exclusive binding because of a steric clash ( xref A )."
40774387
sparser
"It is therefore still unclear whether the ZnF domain of USP16 binds free ISG15 in the same mode as free Ub, and if it plays a regulatory role in ISG15-dependent processes in cells."
38055744
sparser
"Since our R153Agb mutant probes bind and interact with USP16 to some extent, our ongoing investigation also includes understanding the molecular interactions between ISG15 and USP16 that can help design more selective probes with increased affinity for USP18 and minimal or no cross-reactivity with USP16."
39843430
sparser
"Although a structure of the USP16–ISG15 complex remains to be determined, AF3 predicts that ISG15 interacts with USP16 at both N- and C-terminal domains ( xref A )."
40774387
sparser
"Compound 25 was shown to disrupt the wildtype HDAC6/ISG15 BRET signal in a dose-dependent manner to the same level as HDAC6 R1155A, Y1184A . To assess the selectivity of 25 in cells, a NanoBRET assay was designed to assess USP16-ISG15 interaction."
37499118
biogrid
No evidence text available
37499118
USP16 affects cell growth
| 5
USP16 activates cell growth.
| 4
USP16 activates cell growth. 4 / 4
| 4
reach
"Depletion of USP16 significantly increased the cell growth rate and inhibited cell anoikis in vitro (XREF_FIG and XREF_SUPPLEMENTARY)."
27633997
reach
"Cells proliferation were then analysed using a CCK-8 assay, and the results revealed that knockdown of USP16 markedly reduced cell growth in PCa cells."
33546726
reach
"Indeed a knockdown of USP16 or an over-expression of its catalytically inactive form slow down cell growth and interfere with mitosis, suggesting that USP16 is the H2A-DUB responsible for histone H2A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
reach
"These results demonstrate that inhibiting USP16 significantly suppressed PCa cell growth in vivo."
33546726
USP16 inhibits cell growth.
| 1
USP16 inhibits cell growth. 1 / 1
| 1
reach
"Downregulation of USP16 markedly suppressed PCa cell growth both in vitro and in vivo."
33546726
reach
"Wild-type Usp16 rescues Usp16 -/- ESC differentiation defect."
24784029
reach
"When ESCs are differentiated, Usp16 is required to reverse ubH2A mediated gene repression and enables gene activation and subsequent ESC differentiation."
24784029
reach
"Finally, Usp16, but not a catalytically inactive mutant, rescues the differentiation defects of Usp16 -/- ESCs."
24784029
reach
"Usp16 regulates H2A deubiquitination and modulates self-renewal and differentiation in different types of cells."
27633997
reach
"Finally, we demonstrate that Usp16, but not the enzymatically inactive mutant, rescues the differentiation defects of Usp16 -/- ESCs."
24784029
USP16 affects Wnt
| 2 3
USP16 activates Wnt. 5 / 5
| 2 3
reach
"Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation."
30504774
eidos
"Discussion Our data show that Bmi1 and Usp16 , important chromatin regulators in stem cells , modulate Wnt signaling in primary mammary epithelial and fibroblast cells ."
30504774
reach
"Here we report that Usp16, a negative regulator of Bmi1 and PRC1 function, modulates the Wnt pathway in mammary epithelia, primary human fibroblasts and MEFs, affecting their expansion and self-renewal potential."
30504774
eidos
"Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation Regulation of the Wnt pathway in stem cells and primary tissues is still poorly understood ."
30504774
reach
"Usp16 copy number normalization restores normal Wnt activation in Ts65Dn mice models."
30504774
USP16 affects H2AC20
1 2 1 | 1
USP16 binds H2AC20.
2 | 1
USP16 binds H2AC20. 2 / 2
2 |
biogrid
No evidence text available
17914355
biogrid
No evidence text available
21245042
USP3 binds USP16 and H2AC20. 1 / 1
| 1
sparser
"Both USP3 and USP16 are also associated with H2A deubiquitination following DNA damage processing [ xref , xref ]."
20974139
USP16 deubiquitinates H2AC20.
1 1 |
USP16 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
No evidence text available
USP16 deubiquitinates H2AC20 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
reach
"Depletion of USP16 was shown to significantly suppress the growth of PCa cells both in vitro and in vivo."
33546726
reach
"Downregulation of USP16 markedly suppressed PCa cell growth both in vitro and in vivo."
33546726
USP16 activates phenazine-1-carboxylate. 2 / 2
| 2
reach
"These results demonstrate that inhibiting USP16 significantly suppressed PCa cell growth in vivo."
33546726
reach
"USP16 knockdown suppresses growth of PCa tumour xenografts."
33546726
USP16 inhibits cellular senescence.
| 2
reach
"In this way, USP16 antagonizes the self-renewal and senescence pathways in multiple tissues."
26712794
reach
"The deubiquitinating enzyme USP16 suppresses self-renewal and senescence pathways in multiple tissues via deubiquitinating H2AK119 and increasing Ink4a locus transcription [XREF_BIBR], while BMI-1 regulates cell cycle, apoptosis and senescence via inhibiting p16 Ink4a and p19 Arf genes encoded by Ink4a [XREF_BIBR, XREF_BIBR]."
33413418
USP16 activates cellular senescence.
| 2
USP16 activates cellular senescence. 2 / 2
| 2
reach
"In hematopoietic stem cells, Usp16 over expression prematurely induces senescence via p16 Ink4a expression 10."
29523805
reach
"Moreover, Usp16 is associated with decreased ubiquitination of Cdkn2a and accelerated senescence in Ts65Dn fibroblasts."
24025767
eidos
"These results were further confirmed by the fact that depleting USP16 promoted cell proliferation in Hs683 and SW1783 cells ( fig ."
36197973
reach
"USP16 is upregulated in Down 's syndrome (DS) cells due to extrachromosomal triplication in trisomy 21, downregulation of USP16 partially restores the impaired proliferation in DS somatic stem cells."
28018215
USP16 activates cell population proliferation. 2 / 2
| 2
reach
"Concordantly, we found that ectopic expression of USP16 mostly restored the proliferation rate of USP16 knockdown cells."
33546726
reach
"Furthermore, in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and post-natal neural progenitors while downregulation of USP16 partially rescues the proliferation defects of DS fibroblasts."
24025767
USP16 affects NFkappaB
| 3 1
USP16 activates NFkappaB.
| 2
USP16 activates NFkappaB. 2 / 2
| 2
reach
"In addition, transfection of USP16 WT, but not USP16 CI, increased TNF-alpha-induced NF-kappaB activity in HEK293T cells, as demonstrated by NF-kappaB luciferase reporter assays (XREF_FIG and fig."
| PMC
reach
"This result indicates a clear pivotal effect of myeloid USP16 mediated canonical NF-kappaB in experimental colitis model establishment and CRC development."
| PMC
USP16 inhibits NFkappaB.
| 1
USP16 inhibits NFkappaB. 1 / 1
| 1
reach
"Notably, USP16 deficiency greatly impaired the activation of NF-kappaB induced by TNF-alpha (XREF_FIG)."
| PMC
USP16 binds NFkappaB.
| 1
NFkappaB binds USP16. 1 / 1
| 1
isi
"Three bona fide NFkappaB binding sites were found in USP16 promoter."
31888715
USP16 affects HOXD10
| 3 1
USP16 increases the amount of HOXD10.
| 2
USP16 increases the amount of HOXD10. 1 / 1
| 1
reach
"Furthermore inhibition of USP16 activity in vivo in Xenopus embryos similarly reduced HoxD10 gene expression, and resulted in abnormalities in the anterior-posterior patterning of the embryos (Joo et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
Mutated USP16 increases the amount of HOXD10. 1 / 1
| 1
reach
"Wildtype but not catalytic mutant Ubp-M could rescue HoxD10 expression."
20685273
USP16 decreases the amount of HOXD10.
| 1
USP16 decreases the amount of HOXD10. 1 / 1
| 1
reach
"Knockdown of USP16 or an over-expression of its catalytically inactive form in cell lines increased H2AK119Ub levels both globally and at the HoxD10 locus, and suppressed HoxD10 gene expression (Cai e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
USP16 binds HOXD10.
| 1
USP16 binds BMI1 and HOXD10. 1 / 1
| 1
sparser
"ChIP studies on HOXD10 binding of USP16 and the BMI1 subunit of PRC1 found both proteins are localized to the HOXD10 promoter, yet H2A was not ubiquitinated unless USP16 was depleted."
23845989
USP16 affects DGKG
3 | 1
DGKG binds USP16. 4 / 4
3 | 1
biogrid
No evidence text available
37838036
sparser
"Mechanistically, DGKG interacts with USP16 to mediate the deubiquitination of ZEB2, enhancing its protein stability, thus elevating TGF-β release and Treg accumulation."
40051497
biogrid
No evidence text available
37838036
biogrid
No evidence text available
37838036
USP16 affects CDK1
3 1 |
CDK1 binds USP16. 4 / 4
3 1 |
biogrid
No evidence text available
24013421
biogrid
No evidence text available
26323689
biogrid
No evidence text available
10077596
hprd
No evidence text available
10077596
DGKG affects USP16
3 | 1
DGKG binds USP16. 4 / 4
3 | 1
biogrid
No evidence text available
37838036
sparser
"Mechanistically, DGKG interacts with USP16 to mediate the deubiquitination of ZEB2, enhancing its protein stability, thus elevating TGF-β release and Treg accumulation."
40051497
biogrid
No evidence text available
37838036
biogrid
No evidence text available
37838036
MCherry affects USP16
| 3
USP16 binds mCherry. 3 / 3
| 3
sparser
"To determine whether the impaired ZGA was directly caused by the absence of H2AK119ub1 deubiquitination after Usp16 deletion, we overexpressed mCherry-USP16 in fully grown Usp16 -null oocytes by mRNA microinjection."
35640597
sparser
"In a rescue experiment, ectopic expression of mCherry-USP16 in Usp16 -null oocytes by mRNA microinjection could not remove H2AK119ub1 from the chromosomes at GV stage, as we speculated ( xref ), but could at MI stage (Figure xref – xref )."
35640597
sparser
"Cysteine-205 of USP16 was vital for its deubiquitinase activity; as a negative control, when mCherry-USP16 C205S was expressed in Usp16 -null oocytes, it failed to remove H2AK119ub1 from the chromosomes (Figure xref – xref ), indicating that the deubiquitinase activity of USP16 is essential for H2AK119ub1 removal in maturing oocytes."
35640597
ZEB2 affects USP16
3 |
USP16 binds ZEB2. 3 / 3
3 |
biogrid
No evidence text available
37838036
biogrid
No evidence text available
37838036
biogrid
No evidence text available
37838036
XPO1 affects USP16
1 | 2
XPO1 binds USP16. 3 / 3
1 | 2
sparser
"This result suggests that O-GlcNAc decreases nuclear USP16 by promoting USP16-Crm1 binding."
38462164
sparser
"We used TMG + G to increase O-GlcNAcylation, and it strengthened interaction between USP16 and Crm1 ( xref , E and F )."
38462164
biogrid
No evidence text available
24013421
USP16 affects mCherry
| 3
USP16 binds mCherry. 3 / 3
| 3
sparser
"To determine whether the impaired ZGA was directly caused by the absence of H2AK119ub1 deubiquitination after Usp16 deletion, we overexpressed mCherry-USP16 in fully grown Usp16 -null oocytes by mRNA microinjection."
35640597
sparser
"In a rescue experiment, ectopic expression of mCherry-USP16 in Usp16 -null oocytes by mRNA microinjection could not remove H2AK119ub1 from the chromosomes at GV stage, as we speculated ( xref ), but could at MI stage (Figure xref – xref )."
35640597
sparser
"Cysteine-205 of USP16 was vital for its deubiquitinase activity; as a negative control, when mCherry-USP16 C205S was expressed in Usp16 -null oocytes, it failed to remove H2AK119ub1 from the chromosomes (Figure xref – xref ), indicating that the deubiquitinase activity of USP16 is essential for H2AK119ub1 removal in maturing oocytes."
35640597
USP16 affects ZEB2
3 |
USP16 binds ZEB2. 3 / 3
3 |
biogrid
No evidence text available
37838036
biogrid
No evidence text available
37838036
biogrid
No evidence text available
37838036
USP16 affects XPO1
1 | 2
XPO1 binds USP16. 3 / 3
1 | 2
sparser
"This result suggests that O-GlcNAc decreases nuclear USP16 by promoting USP16-Crm1 binding."
38462164
sparser
"We used TMG + G to increase O-GlcNAcylation, and it strengthened interaction between USP16 and Crm1 ( xref , E and F )."
38462164
biogrid
No evidence text available
24013421
USP16 affects Ubiquitin
| 1 2
USP16 binds Ubiquitin.
| 2
sparser
"Aligning the predicted structures of phosphorylated ubiquitin analogues to the reported structures of USP5-Ub D (PDB:) and USP16-Ub D (PDB:) complexes (), xref we found that Thr12 and Thr66 are buried at the interfaces between USP5/USP16 and the distal ubiquitin."
40443892
sparser
"In agreement with the observations made for USP5, nuclear magnetic resonance studies have revealed similar interactions between the USP16 ZnF-UBP domain and the unanchored ubiquitin C-terminal Arg-Gly[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18603431
USP16 increases the amount of Ubiquitin.
| 1
USP16 increases the amount of Ubiquitin. 1 / 1
| 1
reach
"Ubiquintation of histone 2A at sites of DNA damage recruits DNA damage repair proteins, while Usp16 and other de-ubiquintases restore ubiquitin levels to normal approximately 24h after damage XREF_BIBR - XREF_BIBR."
29523805
USP16 affects RNF8
2 | 1
USP16 binds RNF8.
2 |
RNF8 binds USP16. 2 / 2
2 |
biogrid
No evidence text available
25305019
biogrid
No evidence text available
25305019
USP16 activates RNF8.
| 1
USP16 activates RNF8. 1 / 1
| 1
reach
"Whether USP16 targets the products of RNF8 and RNF168- and/or BMI1 and RING1B dependent ubiquitylation remains to be established."
23847653
USP16 affects PRC1
| 2 1
USP16 inhibits PRC1.
| 2
USP16 inhibits PRC1. 2 / 2
| 2
reach
"Interestingly, USP16, which is located on human chromosome 21 and triplicated in Down 's syndrome, reduces the self-renewal of hematopoietic stem cells and the expansion of mammary epithelial cells, neural progenitors and fibroblasts in mice, suggesting that Usp16 may antagonize PRC1 function in the self-renewal and/or senescence pathways 31."
24784029
reach
"Since Bmi1 is known to be critical for the maintenance of neural progenitors XREF_BIBR, XREF_BIBR, XREF_BIBR, we hypothesized that an extra copy of the PRC1 antagonist Usp16 could have a role in regulating also their expansion in Ts65Dn mice."
24025767
USP16 binds PRC1.
| 1
USP16 binds PRC1. 1 / 1
| 1
sparser
"Functionally, PRC1–USP16 activity is essential for mitochondrial morphology, respiration, and proteome stability."
41597171
USP16 affects OGT
| 3
USP16 binds OGT. 3 / 3
| 3
sparser
"To investigate whether USP16 interacts with OGT endogenously, we performed experiments with the anti-USP16 antibody."
38462164
sparser
"Interestingly, we discovered that the interaction between OGT and USP16 was reduced in lysates prepared from the mitotic (M) phase of cells ( xref C ), raising a possibility that the interaction of USP16 and OGT may be cell-cycle dependent."
38462164
sparser
"To confirm this result, we first investigated whether USP16 interacts with OGT, the enzyme responsible for O-GlcNAcylation."
38462164
USP16 affects KDM1A
| 3
USP16 binds KDM1A. 3 / 3
| 3
sparser
"Furthermore, the interaction between USP16 and KDM1A was weakened under hypoxic conditions and was restored by 1400 W (Fig.  xref )."
41339351
sparser
"Our preliminary mass spectrometry data showed that USP16 directly interacts with KDM1A, and in vitro experiments further demonstrated that USP16 enhances KDM1A protein levels."
41339351
sparser
"However, RNF138 silencing enhanced the binding of USP16 to KDM1A in cardiomyocytes (Fig.  xref )."
41339351
USP16 affects H2AC8
1 2 |
USP16 binds H2AC8.
2 |
USP16 binds H2AC8. 2 / 2
2 |
biogrid
No evidence text available
36197973
biogrid
No evidence text available
24013421
USP16 deubiquitinates H2AC8.
1 |
USP16 deubiquitinates H2AC8 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects DNA Damage
| 3
USP16 activates DNA Damage.
| 2
USP16 activates DNA Damage. 2 / 2
| 2
reach
"Thus, the increased Usp16 expression in TS65Dn satellite cells could disrupt DNA repair, induce DNA damage, and impair satellite cell expansion."
29523805
reach
"Overexpression of USP16 may induce excessive DNA damage accumulation, leading to acquisition of prematurely senescent phenotypes in different DS cell types [272, 274]."
32962300
USP16 inhibits DNA Damage.
| 1
USP16 inhibits DNA Damage. 1 / 1
| 1
reach
"Since elevated Usp16 expression contributes to somatic stem cell dysfunction in Down syndrome 10 and Usp16 represses DNA damage responses XREF_BIBR, XREF_BIBR, we asked if Ts65Dn satellite cells accumulate more DNA damage that wild type satellite cells."
29523805
OGT affects USP16
| 3
USP16 binds OGT. 3 / 3
| 3
sparser
"To investigate whether USP16 interacts with OGT endogenously, we performed experiments with the anti-USP16 antibody."
38462164
sparser
"Interestingly, we discovered that the interaction between OGT and USP16 was reduced in lysates prepared from the mitotic (M) phase of cells ( xref C ), raising a possibility that the interaction of USP16 and OGT may be cell-cycle dependent."
38462164
sparser
"To confirm this result, we first investigated whether USP16 interacts with OGT, the enzyme responsible for O-GlcNAcylation."
38462164
KDM1A affects USP16
| 3
USP16 binds KDM1A. 3 / 3
| 3
sparser
"Furthermore, the interaction between USP16 and KDM1A was weakened under hypoxic conditions and was restored by 1400 W (Fig.  xref )."
41339351
sparser
"Our preliminary mass spectrometry data showed that USP16 directly interacts with KDM1A, and in vitro experiments further demonstrated that USP16 enhances KDM1A protein levels."
41339351
sparser
"However, RNF138 silencing enhanced the binding of USP16 to KDM1A in cardiomyocytes (Fig.  xref )."
41339351
IKBKB affects CHUK
| 3
USP16 binds IKBKB and CHUK. 2 / 2
| 2
sparser
"USP16 selectively interacts with IKKβ and IKKα."
| PMC
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
H2AC20 affects USP16
2 | 1
USP16 binds H2AC20. 2 / 2
2 |
biogrid
No evidence text available
17914355
biogrid
No evidence text available
21245042
USP3 binds USP16 and H2AC20. 1 / 1
| 1
sparser
"Both USP3 and USP16 are also associated with H2A deubiquitination following DNA damage processing [ xref , xref ]."
20974139
Ct-HBx affects USP16
| 1 2
Ct-HBx inhibits USP16. 3 / 3
| 1 2
eidos
"[ 94-96 ] Transcriptional downregulation of ubiquitin specific peptidase 16 ( USP16 ) by Ct-HBx is also shown to enhance tumorigenicity and stem-like properties of HCC cells ."
30123836
reach
"The aforementioned results revealed the tumour-suppressive functions of USP16, which could be downregulated by Ct-HBx in liver tumour cells."
27633997
reach
"In conclusion, our study suggests that USP16 is negatively regulated by Ct-HBx and plays a critical role in the pro tumorigenicity of Ct-HBx proteins."
27633997
CHUK affects IKBKB
| 3
USP16 binds IKBKB and CHUK. 2 / 2
| 2
sparser
"USP16 selectively interacts with IKKβ and IKKα."
| PMC
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
Tetrachloromethane increases the amount of USP16. 2 / 2
2 |
ctd
No evidence text available
31150632
ctd
No evidence text available
31919559
Sodium arsenite affects USP16
2 |
Sodium arsenite increases the amount of USP16. 2 / 2
2 |
ctd
No evidence text available
29361514
ctd
No evidence text available
38568856
LncEPAT affects USP16
| 2
LncEPAT inhibits USP16. 2 / 2
| 2
eidos
"We next explored the role of blockade of USP16 by lncEPAT in gliomagenesis using an in vivo mouse model ."
36197973
eidos
"The role of blockade of USP16 by lncEPAT in regulating senescence-like cell growth suppression and GBM tumorigenesis ."
36197973
Lipopolysaccharide increases the amount of USP16.
| 1
Lipopolysaccharide increases the amount of USP16. 1 / 1
| 1
reach
"Furthermore, LPS and TNFalpha, strong activators of the NFkappaB pathway, upregulated the USP16 transcription."
31888715
Lipopolysaccharide activates USP16.
| 1
Lipopolysaccharide activates USP16. 1 / 1
| 1
reach
"Furthermore, we observed significant reductions in nuclear p50 levels and small decreases in nuclear translocated c-Rel and p65 levels in LPS stimulated USP16 deficient BMDMs (XREF_FIG)."
| PMC
Cyclosporin A affects USP16
2 |
Cyclosporin A increases the amount of USP16. 2 / 2
2 |
ctd
No evidence text available
20106945
ctd
No evidence text available
25562108
Bisphenol A affects USP16
2 |
Bisphenol A increases the amount of USP16.
1 |
Bisphenol A increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
25181051
Bisphenol A decreases the amount of USP16.
1 |
Bisphenol A decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
29275510
ZRANB1 affects USP16
2 |
ZRANB1 binds USP16. 2 / 2
2 |
biogrid
No evidence text available
33853758
biogrid
No evidence text available
35944360
WDR54 affects USP16
2 |
USP16 binds WDR54. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
Ubiquitin affects USP16
| 2
sparser
"Aligning the predicted structures of phosphorylated ubiquitin analogues to the reported structures of USP5-Ub D (PDB:) and USP16-Ub D (PDB:) complexes (), xref we found that Thr12 and Thr66 are buried at the interfaces between USP5/USP16 and the distal ubiquitin."
40443892
sparser
"In agreement with the observations made for USP5, nuclear magnetic resonance studies have revealed similar interactions between the USP16 ZnF-UBP domain and the unanchored ubiquitin C-terminal Arg-Gly[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18603431
USP3 affects USP16
| 2
USP3 binds USP16. 1 / 1
| 1
sparser
"For example, UCHL5 promotes DNA resection in an EXO-1- and BLM-dependent manner, and USP3 and USP16 are associated with negative regulation of the RNF8 pathway through their ability to oppose H2A ubiquitination ( xref ; xref )."
27941124
USP3 binds USP16 and H2AC20. 1 / 1
| 1
sparser
"Both USP3 and USP16 are also associated with H2A deubiquitination following DNA damage processing [ xref , xref ]."
20974139
USP16 affects proteolysis
| 2
USP16 inhibits proteolysis. 2 / 2
| 2
reach
"TTK dependent phosphorylation of Usp16 causes protein degradation."
28380042
reach
"RT-PCR with Usp16 specific primers confirmed equivalent mRNA expression, suggesting that Usp16 phosphorylation promotes protein degradation."
28380042
USP16 inhibits nuclear factor erythroid 2-related factor 2. 1 / 1
| 1
reach
"Mechanistically, FGF18 treatment reduces the levels of ubiquitin carboxyl-terminal hydrolase 16 (USP16), leading to increased ubiquitination levels of Kelch Like ECH Associated Protein 1 (KEAP1) and the activation of nuclear factor erythroid 2-related factor 2 (Nrf2)."
37777507
USP16 activates nuclear factor erythroid 2-related factor 2. 1 / 1
| 1
reach
"Mechanistically, FGF18 treatment reduces the levels of ubiquitin carboxyl-terminal hydrolase 16 (USP16), leading to increased ubiquitination levels of Kelch Like ECH Associated Protein 1 (KEAP1) and the activation of nuclear factor erythroid 2-related factor 2 (Nrf2)."
37777507
USP16 affects lncEPAT
| 2
USP16 activates lncEPAT. 2 / 2
| 2
eidos
"In contrast , depleting lncEPAT promoted the expression of these genes in GSC23 cells , while depleting USP16 partially reversed the effect of lncEPAT depletion on the promotion of these genes ( fig ."
36197973
eidos
"The number of senescence cells was significantly increased in xenograft tumor tissues with lncEPAT depletion than in controls , whereas depleting USP16 reversed this effect of lncEPAT depletion ( Fig. 7H ) ."
36197973
USP16 affects ZRANB1
2 |
ZRANB1 binds USP16. 2 / 2
2 |
biogrid
No evidence text available
33853758
biogrid
No evidence text available
35944360
USP16 affects WDR54
2 |
USP16 binds WDR54. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
USP16 affects USP3
| 2
USP3 binds USP16. 1 / 1
| 1
sparser
"For example, UCHL5 promotes DNA resection in an EXO-1- and BLM-dependent manner, and USP3 and USP16 are associated with negative regulation of the RNF8 pathway through their ability to oppose H2A ubiquitination ( xref ; xref )."
27941124
USP3 binds USP16 and H2AC20. 1 / 1
| 1
sparser
"Both USP3 and USP16 are also associated with H2A deubiquitination following DNA damage processing [ xref , xref ]."
20974139
USP16 affects NFE2L2
| 2
NFE2L2 binds USP16. 2 / 2
| 2
sparser
"More importantly, Nrf2 directly binds to the promoter of USP16 and forms a negative feedback loop with USP16."
37777507
sparser
"Mechanistically, nuclear-translocated NRF2 directly binds to the USP16 promoter, establishing a KEAP1-NRF2-USP16 negative feedback loop that refines our understanding of the KEAP1-NRF2-ARE signaling network."
40529211
USP16 affects NEURL4
2 |
USP16 binds NEURL4. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
USP16 affects MKI67
| 1 1
USP16 increases the amount of MKI67.
| 1
USP16 increases the amount of MKI67. 1 / 1
| 1
reach
"IHC staining analysis of the xenograft tissues revealed that inhibiting USP16 reduced Ki67 expression, indicating USP16 knockdown impaired the proliferation of PCa cells."
33546726
USP16 activates MKI67.
| 1
USP16 activates MKI67. 1 / 1
| 1
eidos
"IHC staining analysis of the xenograft tissues revealed that inhibiting USP16 reduced Ki67 expression , indicating USP16 knockdown impaired the proliferation of PCa cells ( Fig. 3d-f ) ."
33546726
USP16 affects JAK1
2 |
USP16 binds JAK1. 2 / 2
2 |
biogrid
No evidence text available
34294846
biogrid
No evidence text available
34294846
USP16 affects IKKs
| 2
USP16 activates IKKs. 2 / 2
| 2
reach
"Substrate specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation."
| PMC
reach
"Substrate specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation."
33523871
USP16 affects IKBKG
| 2
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
CHUK binds IKBKG and USP16. 1 / 1
| 1
sparser
"IKKα and IKKβ contain similar functional domains; thus, we further evaluated the interaction of USP16 with IKKα and NEMO."
| PMC
USP16 affects Histone_H3
| 1 1
USP16 phosphorylates Histone_H3 on S10. 1 / 1
| 1
sparser
"By deubiquitinating H2Aub, USP16 facilitates the phosphorylation of histone H3 Ser10 and chromosome segregation at the onset of mitosis [ xref ]."
36980227
USP16 leads to the phosphorylation of Histone_H3. 1 / 1
| 1
reach
"USP16 specifically deubiquitinates histone H2A on lysine (K) 119 and K15 but not H2B in vivo, which leads to subsequent phosphorylation of H3 and chromosome segregation."
| PMC
USP16 affects Histone_H2A
2 |
USP16 inhibits Histone_H2A.
1 |
USP16 inhibits Histone_H2A. 1 / 1
1 |
signor
"Here we report the identification and functional characterization of the major deubiquitinase for histone H2A, Ubp-M (also called USP16). Ubp-M prefers nucleosomal substrates in vitro, and specifically deubiquitinates histone H2A but not H2B in vitro and in vivo.  This study identifies the major deubiquitinase for histone H2A and demonstrates that H2A deubiquitination is critically involved in cell cycle progression and gene expression."
17914355
USP16 deubiquitinates Histone_H2A.
1 |
USP16 deubiquitinates Histone_H2A. 1 / 1
1 |
signor
"Here we report the identification and functional characterization of the major deubiquitinase for histone H2A, Ubp-M (also called USP16). Ubp-M prefers nucleosomal substrates in vitro, and specifically deubiquitinates histone H2A but not H2B in vitro and in vivo.  This study identifies the major deubiquitinase for histone H2A and demonstrates that H2A deubiquitination is critically involved in cell cycle progression and gene expression."
17914355
USP16 affects H2AC19
1 1 |
USP16 deubiquitinates H2AC19.
1 |
USP16 deubiquitinates H2AC19 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 binds H2AC19.
1 |
USP16 binds H2AC19. 1 / 1
1 |
biogrid
No evidence text available
17914355
USP16 affects H2AC17
1 1 |
USP16 deubiquitinates H2AC17 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 deubiquitinates H2AC17. 1 / 1
1 |
ubibrowser
"USP3 and <span class="match term0">USP16</span> function to remove ubiquitin from histone <span class="match term1">H2A</span> during the DDR"
28778421
USP16 affects FlaG
| 2
USP16 binds FlaG. 2 / 2
| 2
sparser
"Effective targeting and capturing of ectopically expressed full‐length FLAG‐USP16 and FLAG‐USP36 was visualized by in‐gel fluorescence scanning followed by immunoblotting (Figure  xref , S8, Supporting Information)."
40464359
sparser
"To validate our synthetic probes, we evaluated FUBI‐PA against the previously identified FUBI‐reactive proteases USP16 and USP36. [ xref ] To this end, we ectopically expressed full‐length FLAG‐USP16 and FLAG‐USP36 in HEK293T cells (either WT or CA catalytic‐dead mutants) and performed cell lysate activity‐based labeling experiments."
40464359
USP16 affects FAU
2 |
USP16 binds FAU. 2 / 2
2 |
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
USP16 affects EXOSC10
1 1 |
EXOSC10 binds USP16. 2 / 2
1 1 |
biogrid
No evidence text available
15231747
hprd
No evidence text available
15231747
USP16 affects DNM1L
2 |
USP16 binds DNM1L. 2 / 2
2 |
biogrid
No evidence text available
37488647
biogrid
No evidence text available
37488647
USP16 affects DNA repair
| 2
USP16 inhibits DNA repair.
| 1
USP16 inhibits DNA repair. 1 / 1
| 1
reach
"Thus, the increased Usp16 expression in TS65Dn satellite cells could disrupt DNA repair, induce DNA damage, and impair satellite cell expansion."
29523805
USP16 activates DNA repair.
| 1
USP16 bound to HERC2 activates DNA repair. 1 / 1
| 1
reach
"USP16 interacts with HERC2 and modulates the ubiquitination in DNA repair machinery components."
28018215
USP16 affects DHPS
| 2
USP16 inhibits DHPS.
| 1
USP16 inhibits DHPS. 1 / 1
| 1
reach
"USP16 is upregulated in Down 's syndrome (DS) cells due to extrachromosomal triplication in trisomy 21, downregulation of USP16 partially restores the impaired proliferation in DS somatic stem cells."
28018215
USP16 activates DHPS.
| 1
USP16 activates DHPS. 1 / 1
| 1
reach
"Furthermore, in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and post-natal neural progenitors while downregulation of USP16 partially rescues the proliferation defects of DS fibroblasts."
24025767
USP16 affects CRMP1
| 2
USP16 binds CRMP1. 2 / 2
| 2
sparser
"Deubiquitinase USP16 directly interacts with Drp1."
37488647
sparser
"Co-IP and GST pull-down assay were used to detect the direct interaction between USP16 and Drp1, as well as the ubiquitination of Drp1."
37488647
USP16 affects APOM
2 |
APOM binds USP16. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
USP16 affects ALPG
2 |
ALPG binds USP16. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
RPS27A affects USP16
| 2
RPS27A ubiquitinates USP16. 2 / 2
| 2
sparser
"In summary, our data show that USP16 KO and RPS27a ubiquitination not only affect late stages of 40S maturation but also translation."
32129764
sparser
"In a next step, we tested whether USP16 KO and RPS27a ubiquitination also affect translation."
32129764
RNF8 affects USP16
2 |
RNF8 binds USP16. 2 / 2
2 |
biogrid
No evidence text available
25305019
biogrid
No evidence text available
25305019
RELA affects USP16
1 | 1
RELA increases the amount of USP16.
| 1
Modified RELA increases the amount of USP16. 1 / 1
| 1
reach
"We showed that p65 overexpression enhanced endogenous USP16 mRNA level."
31888715
RELA binds USP16.
1 |
RELA binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33438746
Proteasome affects USP16
| 2
Proteasome inhibits USP16.
| 1
Proteasome inhibits USP16. 1 / 1
| 1
reach
"Taken together, these data suggest that Usp16 is a phosphorylation substrate of TTK and that Usp16 phosphorylation on S415, S552, or T554 leads to proteasome degradation of Usp16."
28380042
Proteasome decreases the amount of USP16.
| 1
Proteasome decreases the amount of mutated USP16. 1 / 1
| 1
reach
"Inhibition of the proteasome with 10 muM MG-132 restored expression of the phosphomimetic Usp16 mutant (XREF_FIG)."
28380042
Particulate Matter increases the amount of USP16.
1 |
Particulate Matter increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
37586242
Particulate Matter decreases the amount of USP16.
1 |
Particulate Matter decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
37586242
NFkappaB affects USP16
| 1 1
NFkappaB increases the amount of USP16.
| 1
NFkappaB increases the amount of USP16. 1 / 1
| 1
reach
"Transcriptional activation of USP16 gene expression by NFkappaB signaling."
31888715
NFkappaB binds USP16.
| 1
NFkappaB binds USP16. 1 / 1
| 1
isi
"Three bona fide NFkappaB binding sites were found in USP16 promoter."
31888715
NFE2L2 affects USP16
| 2
NFE2L2 binds USP16. 2 / 2
| 2
sparser
"More importantly, Nrf2 directly binds to the promoter of USP16 and forms a negative feedback loop with USP16."
37777507
sparser
"Mechanistically, nuclear-translocated NRF2 directly binds to the USP16 promoter, establishing a KEAP1-NRF2-USP16 negative feedback loop that refines our understanding of the KEAP1-NRF2-ARE signaling network."
40529211
NEURL4 affects USP16
2 |
USP16 binds NEURL4. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
reach
"To identify whether USP16 serves as a DUB of c-Myc, HEK293T cells were transfected with plasmids encoding HA-ubiquitin and Flag-c-Myc with wild-type USP16 or its catalytically inactive mutant USP16 C205S and treated with MG132."
33546726
reach
"To identify whether USP16 serves as a DUB of c-Myc, HEK293T cells were transfected with plasmids encoding HA-ubiquitin and Flag-c-Myc with wild-type USP16 or its catalytically inactive mutant USP16 C205S and treated with MG132."
33546726
JAK1 affects USP16
2 |
USP16 binds JAK1. 2 / 2
2 |
biogrid
No evidence text available
34294846
biogrid
No evidence text available
34294846
IKBKG affects USP16
| 2
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
CHUK binds IKBKG and USP16. 1 / 1
| 1
sparser
"IKKα and IKKβ contain similar functional domains; thus, we further evaluated the interaction of USP16 with IKKα and NEMO."
| PMC
H2AC8 affects USP16
2 |
USP16 binds H2AC8. 2 / 2
2 |
biogrid
No evidence text available
36197973
biogrid
No evidence text available
24013421
FlaG affects USP16
| 2
USP16 binds FlaG. 2 / 2
| 2
sparser
"Effective targeting and capturing of ectopically expressed full‐length FLAG‐USP16 and FLAG‐USP36 was visualized by in‐gel fluorescence scanning followed by immunoblotting (Figure  xref , S8, Supporting Information)."
40464359
sparser
"To validate our synthetic probes, we evaluated FUBI‐PA against the previously identified FUBI‐reactive proteases USP16 and USP36. [ xref ] To this end, we ectopically expressed full‐length FLAG‐USP16 and FLAG‐USP36 in HEK293T cells (either WT or CA catalytic‐dead mutants) and performed cell lysate activity‐based labeling experiments."
40464359
FAU affects USP16
2 |
USP16 binds FAU. 2 / 2
2 |
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
EXOSC10 affects USP16
1 1 |
EXOSC10 binds USP16. 2 / 2
1 1 |
biogrid
No evidence text available
15231747
hprd
No evidence text available
15231747
DNM1L affects USP16
2 |
USP16 binds DNM1L. 2 / 2
2 |
biogrid
No evidence text available
37488647
biogrid
No evidence text available
37488647
Ct-HBx proteins affects USP16
| 2
Ct-HBx proteins decreases the amount of USP16. 2 / 2
| 2
reach
"Thus, these data indicate that Ct-HBx proteins in liver cancer cells can negatively regulate USP16 expression."
27633997
reach
"Ct-HBx proteins downregulate USP16 expression."
27633997
CRMP1 affects USP16
| 2
USP16 binds CRMP1. 2 / 2
| 2
sparser
"Deubiquitinase USP16 directly interacts with Drp1."
37488647
sparser
"Co-IP and GST pull-down assay were used to detect the direct interaction between USP16 and Drp1, as well as the ubiquitination of Drp1."
37488647
CHUK affects IKBKG
| 2
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
CHUK binds IKBKG and USP16. 1 / 1
| 1
sparser
"IKKα and IKKβ contain similar functional domains; thus, we further evaluated the interaction of USP16 with IKKα and NEMO."
| PMC
CHUK affects IKBKB, and USP16
| 2
USP16 binds IKBKB and CHUK. 2 / 2
| 2
sparser
"USP16 selectively interacts with IKKβ and IKKα."
| PMC
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
CDKN2A affects USP16
| 1 1
CDKN2A binds USP16.
| 1
USP16 binds CDKN2A. 1 / 1
| 1
sparser
"Moreover, Usp16 is associated with decreased ubiquitination of Cdkn2a and accelerated senescence in Ts65Dn fibroblasts."
24025767
CDKN2A activates USP16.
| 1
CDKN2A activates USP16. 1 / 1
| 1
reach
"Usp16 regulation of the Wnt pathway in mouse and human tissues is at least in part mediated by activation of Cdkn2a, a regulator of senescence."
30504774
Air Pollutants affects USP16
2 |
Air Pollutants increases the amount of USP16.
1 |
Air Pollutants increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
37586242
Air Pollutants decreases the amount of USP16.
1 |
Air Pollutants decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
37586242
APOM affects USP16
2 |
APOM binds USP16. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
ALPG affects USP16
2 |
ALPG binds USP16. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
Δ affects USP16
| 1
Δ decreases the amount of USP16. 1 / 1
| 1
reach
"HBxΔC suppresses expression of genes such as growth arrest-specific 2 and ubiquitin specific peptidase 16 and attenuates their activities in suppressing HCC cell proliferation and tumorigenesis [ 29 ][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30583072
Zinc chromate affects USP16
1 |
Zinc chromate increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
38479592
Valproic acid affects USP16
1 |
Valproic acid decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
23179753
Tungsten affects USP16
1 |
Tungsten decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
30912803
Titanium dioxide affects USP16
1 |
Titanium dioxide demethylates USP16. 1 / 1
1 |
ctd
No evidence text available
35295148
Thiram affects USP16
1 |
Thiram increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
38568856
Thimerosal affects USP16
1 |
Thimerosal increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
27188386
Testosterone affects USP16
1 |
Testosterone decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
33848595
Tert-Butylhydroperoxide increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
18804290
Succimer affects USP16
1 |
Succimer increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
26378955
Streptozocin affects USP16
1 |
Streptozocin increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
28946194
Sorafenib affects USP16
1 |
Sorafenib decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
39786591
Silver(0) affects USP16
1 |
Silver(0) increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
27131904
Schizandrin B affects USP16
1 |
Schizandrin B decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
31150632
Rotenone affects USP16
1 |
Rotenone decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
39786591
Resveratrol affects USP16
1 |
Resveratrol increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
23557933
Rep affects USP16
1 |
Rep binds USP16. 1 / 1
1 |
biogrid
No evidence text available
| DOI
Propiconazole affects USP16
1 |
Propiconazole increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
21278054
Progesterone affects USP16
1 |
Progesterone increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
23012394
Piroxicam affects USP16
1 |
Piroxicam increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
21858171
Phorbol 13-acetate 12-myristate increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
25613284
Perfluorooctane-1-sulfonic acid decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
27153767
Methyl methanesulfonate increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
26011545
Methamphetamine affects USP16
1 |
Methamphetamine decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
29802913
Magnetite nanoparticle increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
26378955
Lipopolysaccharide, E coli O55-B5 increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
24972896
Jinfukang affects USP16
1 |
Jinfukang decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
27392435
Ionomycin affects USP16
1 |
Ionomycin increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
25613284
Hypochlorous acid affects USP16
1 |
Hypochlorous acid increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
19376150
Hsa-miR-93-5p affects USP16
1 |
Hsa-miR-93-5p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-519d-3p affects USP16
1 |
Hsa-miR-519d-3p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-324-5p affects USP16
1 |
Hsa-miR-324-5p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-30a-5p affects USP16
1 |
Hsa-miR-30a-5p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-20b-5p affects USP16
1 |
Hsa-miR-20b-5p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-20a-5p affects USP16
1 |
Hsa-miR-20a-5p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-182-5p affects USP16
1 |
Hsa-miR-182-5p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-17-5p affects USP16
1 |
Hsa-miR-17-5p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-106b-5p affects USP16
1 |
Hsa-miR-106b-5p decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hist1h3g affects USP16
1 |
USP16 binds hist1h3g. 1 / 1
1 |
biogrid
No evidence text available
21090589
Haloperidol affects USP16
1 |
Haloperidol increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
29458080
Hairpins affects USP16
| 1
Hairpins decreases the amount of USP16. 1 / 1
| 1
reach
"These hairpins reduce Usp16 expression to 40-50% leading to a final expression level similar to the one observed in control animals (XREF_SUPPLEMENTARY)."
24025767
Gold atom affects USP16
1 |
Gold atom decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
25523186
Esculetin affects USP16
1 |
Esculetin decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
28946194
Dieldrin affects USP16
1 |
Dieldrin increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
20438755
Dicrotophos affects USP16
1 |
Dicrotophos decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
28302478
Crocidolite asbestos decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
29279043
Copper(II) sulfate increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
19549813
Cobalt dichloride affects USP16
1 |
Cobalt dichloride increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
24612858
Chromium(6+) affects USP16
1 |
Chromium(6+) increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
38479592
Chlorpyrifos affects USP16
1 |
Chlorpyrifos decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
37019170
Chlordecone affects USP16
1 |
Chlordecone decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
33711761
Cadmium dichloride increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
26472689
Cadmium atom affects USP16
1 |
Cadmium atom decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
18522720
C-Myc signalling affects USP16
| 1
C-Myc signalling activates USP16. 1 / 1
| 1
eidos
"Besides , it remains to explore whether c-Myc signalling could activate USP16 expression , resulting in a positive feedback loop that further promotes tumourigenesis ."
33546726
C-Myc knockdown affects USP16
| 1
C-Myc knockdown inhibits USP16. 1 / 1
| 1
reach
"Colony formation assays results suggest that c-Myc knockdown could abolish the effect of USP16 knockdown in terms of both cell proliferation and growth."
33546726
Bis(2-ethylhexyl) phthalate decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
33754040
Beta-lapachone affects USP16
1 |
Beta-lapachone decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
38218311
Benzo[a]pyrene affects USP16
1 |
Benzo[a]pyrene decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
22641617
Benzene affects USP16
1 |
Benzene decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
15929907
Atrazine affects USP16
1 |
Atrazine increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
25929836
Aristolochic acid A decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
33212167
Aldehydo-D-glucose increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
22634610
ZC2HC1A affects USP16
1 |
ZC2HC1A binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
YP_009227196 affects USP16
1 |
YP_009227196 binds USP16. 1 / 1
1 |
virhostnet
No evidence text available
30037810
XRN2 affects USP16
1 |
USP16 binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
35914814
USP5 affects USP16
| 1
USP5 binds USP16. 1 / 1
| 1
sparser
"Therefore, phosphorylation at Thr12 and Thr66 may be incompatible with binding to USP5 and USP16."
40443892
USP36 affects USP16
| 1
USP36 binds USP16. 1 / 1
| 1
sparser
"Binding of USP36 or USP16 to Fubi-PA led to pronounced protein stabilization as assessed by an increase in melting temperature, while binding to ubiquitin-PA for USP36, USP16 and USP2 correlated with even larger protein stability (Fig. xref )."
37443395
USP3 affects H2AC20
| 1
USP3 binds USP16 and H2AC20. 1 / 1
| 1
sparser
"Both USP3 and USP16 are also associated with H2A deubiquitination following DNA damage processing [ xref , xref ]."
20974139
USP27X affects USP16
1 |
USP27X binds USP16. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP26 affects USP16
1 |
USP26 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
38880224
USP25 affects USP16
| 1
USP25 binds USP16. 1 / 1
| 1
sparser
"To better understand the structural basis for differences between USP16 and USP21 recognition of H2AK119ub despite the similarity in their catalytic domains, we examined the potential contacts that could be formed by USP21 and USP16 in each of the complexes with H2AK119ub nucleosomes."
41071870
USP16 affects ubiquitination endogenous Tektins
| 1
USP16 inhibits ubiquitination endogenous Tektins. 1 / 1
| 1
eidos
"Furthermore , we analyzed the influence of USP16 on Tektin ubiquitination and found that the down-regulation of USP16 markedly enhanced the ubiquitination of endogenous Tektins ( Fig. 6G ) ."
36206347
USP16 affects ubiquitination endogenous IKKbeta
| 1
USP16 inhibits ubiquitination endogenous IKKbeta. 1 / 1
| 1
eidos
"Although no effect on the protein levels of IKKbeta was detected , USP16 deficiency significantly promoted the ubiquitination of endogenous IKKbeta ( Fig. 4E ) ."
| PMC
USP16 affects ubiquitination Tektins
| 1
USP16 inhibits ubiquitination Tektins. 1 / 1
| 1
eidos
"( G ) Western blotting showed that the down-regulated USP16 contributed to the increased ubiquitination levels of Tektins ."
36206347
USP16 affects ubiquitin-mediated Tektins
| 1
USP16 inhibits ubiquitin-mediated Tektins. 1 / 1
| 1
eidos
"CEP78 plays a role in sperm-connecting piece formation by up-regulating USP16 expression , and this increase in USP16 expression inhibits ubiquitin-mediated degradation of Tektins to regulate the biogenesis of sperm flagella ."
36206347
USP16 affects ubiquitin mark
| 1
USP16 inhibits ubiquitin mark. 1 / 1
| 1
reach
"Simultaneous tethering of RING1B and USP16 to the array completely eliminated the H2A-K119 ubiquitin mark from the array (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY)."
28416769
USP16 affects uH2A
| 1
USP16 inhibits uH2A. 1 / 1
| 1
eidos
"Knockdown of Usp16 leads to an increase in uH2A and a decrease in the number of cells undergoing mitosis ( 153 ) ."
19489724
USP16 affects tumor growth
| 1
USP16 inhibits tumor growth. 1 / 1
| 1
eidos
"Furthermore , USP16 is involved in human hepatocellular carcinoma , since USP16 down-regulation critically promoted tumor growth ( 35 ) ."
| PMC
USP16 affects transcription DNA sites
| 1
USP16 activates transcription DNA sites. 1 / 1
| 1
eidos
"Depletion of USP16 increases H2A ubiquitylation and restores the otherwise repressed transcription at DNA damage sites ."
31164001
USP16 affects rescue defect
| 1
USP16 inhibits rescue defect. 1 / 1
| 1
eidos
"Knockdown of Usp16 causes a decrease in Hox expression and the rescue from this defect requires the deubiquitinating activity of Usp16 ."
19489724
USP16 affects rep
1 |
Rep binds USP16. 1 / 1
1 |
biogrid
No evidence text available
| DOI
USP16 affects prostate cancer cell growth
| 1
USP16 activates prostate cancer cell growth. 1 / 1
| 1
eidos
"In contrast , down-regulation of USP16 markedly suppressed prostate cancer cell growth both in vitro and in vivo ( 38 ) ."
36197973
USP16 affects primary tissues
| 1
USP16 activates primary tissues. 1 / 1
| 1
eidos
"Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation Regulation of the Wnt pathway in stem cells and primary tissues is still poorly understood ."
30504774
USP16 affects primary mammary epithelial fibroblast cells
| 1
USP16 activates primary mammary epithelial fibroblast cells. 1 / 1
| 1
eidos
"Discussion Our data show that Bmi1 and Usp16 , important chromatin regulators in stem cells , modulate Wnt signaling in primary mammary epithelial and fibroblast cells ."
30504774
USP16 affects polyubiquitination c-Myc
| 1
USP16 inhibits polyubiquitination c-Myc. 1 / 1
| 1
eidos
"Besides , the knockdown of USP16 significantly enhanced the polyubiquitination of c-Myc ( Fig. 5h ) ."
33546726
USP16 affects p105 phosphorylation Usp16 acts histone H2A deubiquitinase H2A deubiquitination subsequent ESCs hematopoietic system
| 1
USP16 activates p105 phosphorylation Usp16 acts histone H2A deubiquitinase H2A deubiquitination subsequent ESCs hematopoietic system. 1 / 1
| 1
eidos
"USP16 specifically promotes p105 phosphorylation Usp16 acts as a histone H2A deubiquitinase to promote H2A deubiquitination and subsequent gene expression in ESCs and the hematopoietic system ( 31 , 32 ) ."
| PMC
USP16 increases the amount of p-tolyl beta-D-glucuronide. 1 / 1
| 1
reach
"Histone deubiquitination has been the subject of recent reviews [XREF_BIBR, XREF_BIBR, XREF_BIBR], and here we highlight three DUBs, USP7, USP16, and BAP1, that function in polycomb group (PcG) complexes and modulate transcription of PcG target genes."
23845989
reach
"Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis."
26323689
USP16 affects miR-146a
| 1
USP16 increases the amount of miR-146a. 1 / 1
| 1
isi
"CLL-Exo treatment up-regulated miR-146a and down-regulated expression of CAF markers (alpha-SMA and FAP) and USP16."
32770182
USP16 affects lncEPAT ubH2A
| 1
USP16 activates lncEPAT ubH2A. 1 / 1
| 1
eidos
"Further , we found that lncEPAT depletion on the levels of ubH2A was reversed by further depletion of USP16 ( fig ."
36197973
USP16 affects lncEPAT tumor sphere cell
| 1
USP16 activates lncEPAT tumor sphere cell. 1 / 1
| 1
eidos
"We found that , in GSC23 and GSC2 cells , depleting USP16 reversed the effect of lncEPAT knockdown on tumor sphere formation and cell proliferation ( Fig. 7 , D to F ) ."
36197973
USP16 affects lncEPAT senescence
| 1
USP16 activates lncEPAT senescence. 1 / 1
| 1
eidos
"S4D ) , while depletion of USP16 reversed the effect of lncEPAT knockdown on GSC senescence ( Fig. 6E ) ."
36197973
USP16 increases the amount of lipopolysaccharide. 1 / 1
| 1
reach
"Furthermore, LPS and TNFalpha, strong activators of the NFkappaB pathway, upregulated the USP16 transcription."
31888715
USP16 affects interaction IKKbeta p105
| 1
USP16 activates interaction IKKbeta p105. 1 / 1
| 1
eidos
"Consistently , the interaction between IKKbeta and p105 in MEFs stimulated by TNF-alpha was also disrupted by the absence of USP16 , indicating that USP16 is broadly essential for the binding of p105 and IKKbeta in various cell types ( Fig. 4B ) ."
| PMC
USP16 affects inflammatory cytokines
| 1
USP16 activates inflammatory cytokines. 1 / 1
| 1
eidos
"The absence of USP16 not only suppressed the expression of inflammatory cytokines but also significantly inhibited the levels of costimulators , such as CD40 , CD80 , and CD86 , on the surfaces of BMDMs ( Fig. 5C ) ."
| PMC
USP16 affects hist1h3g
1 |
USP16 binds hist1h3g. 1 / 1
1 |
biogrid
No evidence text available
21090589
USP16 affects half-life protein
| 1
USP16 activates half-life protein. 1 / 1
| 1
eidos
"We found that ectopic expression of USP16 enhanced the stability of c-Myc protein , while USP16 knockdown reduced the half-life of c-Myc protein ( Fig. 4e and f ) ."
33546726
USP16 affects growth PCa cells
| 1
USP16 activates growth PCa cells. 1 / 1
| 1
eidos
"Depletion of USP16 was shown to significantly suppress the growth of PCa cells both in vitro and in vivo ."
33546726
USP16 affects expansion fibroblasts neurosphere neural progenitor cells
| 1
USP16 inhibits expansion fibroblasts neurosphere neural progenitor cells. 1 / 1
| 1
eidos
"LncEPAT attenuates USP16-mediated tumor suppression Although USP16 has been shown to reduce the expansion of normal fibroblasts and neurosphere formation of neural progenitor cells ( 16 ) , its role in tumorigenesis of glioma is unknown ."
36197973
USP16 affects epithelials
| 1
USP16 inhibits epithelials. 1 / 1
| 1
eidos
"Taken together , these data show that Usp16 limits the activation of the Wnt pathway in mammary epithelials , affecting the growth of basal cells ."
30504774
USP16 affects endogenous IKKbeta
| 1
USP16 leads to the ubiquitination of endogenous IKKbeta. 1 / 1
| 1
reach
"Although no effect on the protein levels of IKKbeta was detected, USP16 deficiency significantly promoted the ubiquitination of endogenous IKKbeta (XREF_FIG)."
| PMC
USP16 affects delayed tumour onset mice
| 1
USP16 inhibits delayed tumour onset mice. 1 / 1
| 1
eidos
"In addition , the inhibition of USP16 led to a delayed tumour onset in nude mice ( Fig. 3c ) ."
33546726
USP16 affects costimulators such CD40 CD86 surfaces BMDMs
| 1
USP16 activates costimulators such CD40 CD86 surfaces BMDMs. 1 / 1
| 1
eidos
"The absence of USP16 not only suppressed the expression of inflammatory cytokines but also significantly inhibited the levels of costimulators , such as CD40 , CD80 , and CD86 , on the surfaces of BMDMs ( Fig. 5C ) ."
| PMC
USP16 affects cells undergoing mitosis
| 1
USP16 activates cells undergoing mitosis. 1 / 1
| 1
eidos
"Knockdown of Usp16 leads to an increase in uH2A and a decrease in the number of cells undergoing mitosis ( 153 ) ."
19489724
USP16 affects cell growth PCa cells
| 1
USP16 activates cell growth PCa cells. 1 / 1
| 1
eidos
"Cells proliferation were then analysed using a CCK-8 assay , and the results revealed that knockdown of USP16 markedly reduced cell growth in PCa cells ( Fig. 2b and c ) ."
33546726
USP16 affects cell cycle processing
| 1
USP16 activates cell cycle processing. 1 / 1
| 1
eidos
"In mammalian cells , USP16 is expressed diffusely during mitosis and contributes to cell cycle processing ."
| PMC
USP16 affects c-Myc protein abundance
| 1
USP16 activates c-Myc protein abundance. 1 / 1
| 1
eidos
"We found that knockdown of USP16 dramatically reduced c-Myc protein abundance but did not affect its mRNA levels ( Fig. 4a and b ) , suggesting that the regulation of c-Myc by USP16 occurs at the post-transcriptional level ."
33546726
USP16 affects c-Myc abundance
| 1
USP16 activates c-Myc abundance. 1 / 1
| 1
eidos
"In addition , knockdown of USP16 significantly reduced c-Myc abundance at the post-translational level , while overexpression of wild-type USP16 , instead of its catalytic-inactive mutant ( C205S ) [ 23 ] , stabilized c-Myc ."
33546726
USP16 affects activation p105 IKK complex LPS
| 1
USP16 activates activation p105 IKK complex LPS. 1 / 1
| 1
eidos
"USP16 deficiency strongly inhibited the activation of p105 by the typical IKK complex under LPS stimulation , as revealed by an in vitro kinase assay ( Fig. 3G ) ."
| PMC
USP16 affects activation NF-kappaB induced TNF-alpha
| 1
USP16 activates activation NF-kappaB induced TNF-alpha. 1 / 1
| 1
eidos
"Notably , USP16 deficiency greatly impaired the activation of NF-kappaB induced by TNF-alpha ( Fig. 3 , E and F ) ."
| PMC
USP16 affects abundance c-Myc
| 1
USP16 activates abundance c-Myc. 1 / 1
| 1
eidos
"Analysis of c-Myc protein levels by Western blot revealed that knockdown of USP16 significantly decreased the abundance of c-Myc ( Fig. 1d ) ."
33546726
USP16 affects ZC2HC1A
1 |
ZC2HC1A binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
USP16 affects YP_009227196
1 |
YP_009227196 binds USP16. 1 / 1
1 |
virhostnet
No evidence text available
30037810
USP16 affects XRN2
1 |
USP16 binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
35914814
USP16 affects VIM
| 1
USP16 increases the amount of VIM. 1 / 1
| 1
reach
"As shown in XREF_FIG, expression of the Igf2, Vimentin, Gata4, Gata6, and Foxa2 genes was significantly increased in EBs formed from Usp16 -/- ESCs rescued by wild-type Usp16."
24784029
USP16 affects USP5
| 1
USP5 binds USP16. 1 / 1
| 1
sparser
"Therefore, phosphorylation at Thr12 and Thr66 may be incompatible with binding to USP5 and USP16."
40443892
USP16 affects USP36
| 1
USP36 binds USP16. 1 / 1
| 1
sparser
"Binding of USP36 or USP16 to Fubi-PA led to pronounced protein stabilization as assessed by an increase in melting temperature, while binding to ubiquitin-PA for USP36, USP16 and USP2 correlated with even larger protein stability (Fig. xref )."
37443395
USP16 affects USP27X
1 |
USP27X binds USP16. 1 / 1
1 |
biogrid
No evidence text available
38030604
USP16 affects USP26
1 |
USP26 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
38880224
USP16 affects USP25
| 1
USP25 binds USP16. 1 / 1
| 1
sparser
"To better understand the structural basis for differences between USP16 and USP21 recognition of H2AK119ub despite the similarity in their catalytic domains, we examined the potential contacts that could be formed by USP21 and USP16 in each of the complexes with H2AK119ub nucleosomes."
41071870
USP16 affects USP16
| 1
USP16 activates USP16. 1 / 1
| 1
reach
"Concordantly, we found that ectopic expression of USP16 mostly restored the proliferation rate of USP16 knockdown cells."
33546726
USP16 affects UBE3A
1 |
UBE3A binds USP16. 1 / 1
1 |
biogrid
No evidence text available
22645313
USP16 affects UBD
1 |
USP16 binds UBD. 1 / 1
1 |
biogrid
No evidence text available
21090589
USP16 affects Tektin
| 1
USP16 activates Tektin. 1 / 1
| 1
eidos
"( E ) Western blotting showing that the up-regulated USP16 increased Tektin expression ( two-sided Student 's t test ; * P < 0.05 ; error bars , SEM ) ."
36206347
USP16 affects TXNL1
1 |
TXNL1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP16 affects TTK
1 |
TTK binds USP16. 1 / 1
1 |
biogrid
No evidence text available
28380042
USP16 affects TSR1
1 |
TSR1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
USP16 affects TRIM67
1 |
TRIM67 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36215168
USP16 affects TNF
| 1
USP16 increases the amount of TNF. 1 / 1
| 1
reach
"Furthermore, LPS and TNFalpha, strong activators of the NFkappaB pathway, upregulated the USP16 transcription."
31888715
USP16 affects TKT
1 |
TKT binds USP16. 1 / 1
1 |
biogrid
No evidence text available
40593561
USP16 affects TIPARP
1 |
TIPARP binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35439318
USP16 affects TBX3
| 1
TBX3 binds HOXD11, GSN, and USP16. 1 / 1
| 1
sparser
"As shown in xref , Usp16 binding to promoter regions of Tbx3, HoxD11, and Gsn genes, which are activated during Usp16 +/+ ESC differentiation, were significantly reduced in Usp16 −/− EBs as compared to Usp16 +/+ EBs."
24784029
USP16 affects SUZ12
1 |
SUZ12 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
27634302
USP16 affects STAU1
1 |
STAU1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36232890
USP16 affects SRPRB
1 |
SRPRB binds USP16. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP16 affects SOST
1 |
SOST binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP16 affects SEC24A
1 |
SEC24A binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
USP16 affects SEC23A
1 |
SEC23A binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
USP16 affects SATB1
1 |
USP16 binds SATB1. 1 / 1
1 |
biogrid
No evidence text available
35914814
USP16 affects Rspo-mediated LRP6 phosphorylation
| 1
USP16 activates Rspo-mediated LRP6 phosphorylation. 1 / 1
| 1
eidos
"Usp16 and p16Ink4a modulate Rspo-mediated LRP6 phosphorylation The Wnt pathway can be modulated via multiple mechanisms including expression of different extracellular receptor components as well as variations in the expression of intracellular signal transducers ."
30504774
USP16 affects RPS27A
1 |
USP16 deubiquitinates RPS27A. 1 / 1
1 |
ubibrowser
"<span class="match term0">USP16</span> counteracts mono-ubiquitination of <span class="match term1">RPS27a</span> and promotes maturation of the 40S ribosomal subunit"
32129764
USP16 affects RPS20
1 |
RPS20 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
34079125
USP16 affects RPS16
1 |
RPS16 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
USP16 affects RPS11
1 |
RPS11 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
USP16 affects RPLP0
| 1
RLP24 binds RPLP0 and USP16. 1 / 1
| 1
sparser
"The absence of the 60S trans-acting factor RLP24 and the ribosomal protein RPL23a/uL23 further confirmed that USP16 specifically binds to 40S precursors."
32129764
USP16 affects RNF168
| 1
USP16 activates RNF168. 1 / 1
| 1
reach
"Whether USP16 targets the products of RNF8 and RNF168- and/or BMI1 and RING1B dependent ubiquitylation remains to be established."
23847653
USP16 affects RNF112
1 |
RNF112 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
40178292
USP16 affects RLP24
| 1
RLP24 binds RPLP0 and USP16. 1 / 1
| 1
sparser
"The absence of the 60S trans-acting factor RLP24 and the ribosomal protein RPL23a/uL23 further confirmed that USP16 specifically binds to 40S precursors."
32129764
USP16 affects RELA
1 |
RELA binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33438746
USP16 affects RACK1
1 |
RACK1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
USP16 affects PTOV1
1 |
USP16 binds PTOV1. 1 / 1
1 |
biogrid
No evidence text available
21090589
USP16 affects PPL
1 |
PPL binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP16 affects PPIA
1 |
USP16 binds PPIA. 1 / 1
1 |
biogrid
No evidence text available
38334954
USP16 affects PLEKHA4
1 |
PLEKHA4 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
31091453
USP16 affects PCa tumour growth
| 1
USP16 activates PCa tumour growth. 1 / 1
| 1
eidos
"Knockdown of USP16 impeded PCa tumour growth in vivo ."
33546726
USP16 affects PCa cells
| 1
USP16 activates PCa cells. 1 / 1
| 1
eidos
"IHC staining analysis of the xenograft tissues revealed that inhibiting USP16 reduced Ki67 expression , indicating USP16 knockdown impaired the proliferation of PCa cells ( Fig. 3d-f ) ."
33546726
USP16 affects PCa cell viability
| 1
USP16 activates PCa cell viability. 1 / 1
| 1
eidos
"Disrupting USP16 impairs PCa cell viability ."
33546726
USP16 affects PCa cell growth
| 1
USP16 activates PCa cell growth. 1 / 1
| 1
eidos
"These results demonstrate that inhibiting USP16 significantly suppressed PCa cell growth in vivo ."
33546726
USP16 affects PBD
| 1
USP16 binds PBD. 1 / 1
| 1
reach
"Examination of the GST pull-down complexes showed that Usp16 specifically interacted with the wild-type (WT) PBD but not the PBD2A mutant (XREF_FIG), indicating that the interaction between Plk1 and Usp16 is PBD dependent."
26323689
USP16 affects PAX6
1 |
USP16 binds PAX6. 1 / 1
1 |
biogrid
No evidence text available
35914814
USP16 affects PAK1
1 |
PAK1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
USP16 affects OSCP1
1 |
USP16 binds OSCP1. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP16 affects Neoplasms
| 1
USP16 inhibits Neoplasms. 1 / 1
| 1
eidos
"A previous report shows that USP16 down-regulation promoted Hepatocellular carcinoma ( HCC ) tumorigenicity and malignancy ( 37 ) ."
36197973
USP16 affects NR2C2
1 |
NR2C2 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
30463901
USP16 affects NLRP3
| 1
USP16 binds NLRP3. 1 / 1
| 1
sparser
"Mechanically, USP16 directly binds to the NLRP3 protein to eliminate K48 ubiquitination modification, enhancing the stability of the NLRP3 protein, activating inflammasome activity."
41591834
USP16 affects NANOG
1 |
USP16 deubiquitinates NANOG. 1 / 1
1 |
USP16 affects NAA40
1 |
NAA40 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33916271
USP16 affects N
1 |
N binds USP16. 1 / 1
1 |
biogrid
No evidence text available
| DOI
USP16 affects MAD1L1
1 |
USP16 binds MAD1L1. 1 / 1
1 |
biogrid
No evidence text available
35831314
USP16 affects LRRC59
1 |
LRRC59 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
32788342
USP16 affects LRP6 phosphorylation
| 1
USP16 activates LRP6 phosphorylation. 1 / 1
| 1
eidos
"Usp16 and p16Ink4a modulates Rspo-mediated LRP6 phosphorylation ."
30504774
USP16 affects LINC02381
1 |
LINC02381 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36197973
USP16 affects LIN
| 1
USP16 activates LIN. 1 / 1
| 1
reach
"Like HSCs, Usp16 mRNA expression was increased approximately 1.5 fold in Ts65Dn CD49f + CD24 med Lin - cells compared to control cells (XREF_SUPPLEMENTARY)."
24025767
USP16 affects LDLR
| 1
USP16 binds LDLR. 1 / 1
| 1
sparser
"Co-immunoprecipitation revealed that USP16 interacts with LDLR and deubiquitinates the receptor, thus protecting it against degradation ( xref J)."
36980227
USP16 affects Kinetochore
| 1
USP16 leads to the ubiquitination of Kinetochore. 1 / 1
| 1
reach
"Ubiquitin-specific peptidase 16 (Usp16) antagonizes the activity of CUL-3-based ubiquitin ligase by deubiquitinating PLK1 at the kinetochore [94]."
35563642
USP16 affects Ink4a locus [
| 1
USP16 increases the amount of Ink4a locus [. 1 / 1
| 1
reach
"The deubiquitinating enzyme USP16 removes the ubiquitin protein from H2A-K119, and upregulates the transcription of the Ink4a locus [XREF_BIBR]."
26712794
USP16 affects ILF3
1 |
ILF3 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
USP16 affects IGF2
| 1
USP16 increases the amount of IGF2. 1 / 1
| 1
reach
"As shown in XREF_FIG, expression of the Igf2, Vimentin, Gata4, Gata6, and Foxa2 genes was significantly increased in EBs formed from Usp16 -/- ESCs rescued by wild-type Usp16."
24784029
USP16 affects Histone_H2B
| 1
USP16 deubiquitinates Histone_H2B on lysine. 1 / 1
| 1
reach
"USP16 specifically deubiquitinates histone H2A on lysine (K) 119 and K15 but not H2B in vivo, which leads to subsequent phosphorylation of H3 and chromosome segregation."
| PMC
biogrid
No evidence text available
28855339
USP16 affects His2A
| 1
USP16 activates His2A. 1 / 1
| 1
reach
"Several independent pieces of data suggest a functional relationship between uH2A levels and DISC : (i) expression of an H2A allele that can not be monoubiquitylated at lysine 119 partially rescues transcription (XREF_FIG), (ii) inhibition of the known H2A E3 ubiquitin ligase RNF8 and the related RNF168 partially reverses silencing (XREF_FIG), and (iii) depletion of the uH2A deubiquitylating enzyme USP16 prevents the reversal of silencing and diminution of uH2A at DSBs upon ATMi or cessation of damage."
20550933
USP16 affects Hepatocellular carcinoma HCC tumorigenicity
| 1
USP16 inhibits Hepatocellular carcinoma HCC tumorigenicity. 1 / 1
| 1
eidos
"A previous report shows that USP16 down-regulation promoted Hepatocellular carcinoma ( HCC ) tumorigenicity and malignancy ( 37 ) ."
36197973
USP16 affects HSPD1
1 |
HSPD1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
30021884
USP16 affects HOXD11
| 1
TBX3 binds HOXD11, GSN, and USP16. 1 / 1
| 1
sparser
"As shown in xref , Usp16 binding to promoter regions of Tbx3, HoxD11, and Gsn genes, which are activated during Usp16 +/+ ESC differentiation, were significantly reduced in Usp16 −/− EBs as compared to Usp16 +/+ EBs."
24784029
USP16 affects HGS
1 |
HGS binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
USP16 affects HDLBP
1 |
HDLBP binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
USP16 affects HDAC1
1 |
HDAC1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
40437099
USP16 affects HBxDelta35
| 1
USP16 inhibits HBxDelta35. 1 / 1
| 1
reach
"The levels of USP16 mRNA were also decreased in Huh7 and PLC/PRF/5 cells overexpressing HBxDelta35 (XREF_FIG)."
27633997
USP16 affects H4C16
1 |
USP16 binds H4C16. 1 / 1
1 |
biogrid
No evidence text available
21090589
USP16 affects H2BC3
1 |
USP16 binds H2BC3. 1 / 1
1 |
biogrid
No evidence text available
24013421
USP16 affects H2BC21
1 |
USP16 deubiquitinates H2BC21. 1 / 1
1 |
ubibrowser
" <span class="match term0">UBP-M</span> may deubiquitinate several critical proteins that are involved in the condensation of mitotic chromosomes, mainly on ubiquitinated proteins of the chromatin such as histones H2A and <span class="match term1">H2B</span> "
20730552
USP16 affects H2BC13
1 |
USP16 binds H2BC13. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP16 affects H2BC12
1 |
H2BC12 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
34349018
USP16 affects H2BC10
1 |
H2BC10 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
34349018
USP16 affects H2Aub1
| 1
USP16 deubiquitinates H2Aub1. 1 / 1
| 1
reach
"This kinase phosphorylates and activates the Usp16 deubiquitinase, which then deubiquitinates H2Aub1 (XREF_FIG)."
26665172
USP16 affects H2AZ1
1 |
USP16 binds H2AZ1. 1 / 1
1 |
biogrid
No evidence text available
21245042
USP16 affects H2AK119ub
| 1
USP16 inhibits H2AK119ub. 1 / 1
| 1
eidos
"Interestingly , these changes are reversible as H2AK119ub mediated transcriptional silencing is regulated by USP16 , which erases H2AK119ub ( Shanbhag et al ., 2010 ) ."
31164001
USP16 affects H2AK119Ub
| 1
USP16 increases the amount of H2AK119Ub. 1 / 1
| 1
reach
"Knockdown of USP16 or an over-expression of its catalytically inactive form in cell lines increased H2AK119Ub levels both globally and at the HoxD10 locus, and suppressed HoxD10 gene expression (Cai e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
USP16 affects H2AC7
1 |
USP16 deubiquitinates H2AC7 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects H2AC6
1 |
USP16 deubiquitinates H2AC6 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects H2AC25
1 |
USP16 deubiquitinates H2AC25 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects H2AC21
1 |
USP16 deubiquitinates H2AC21 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects H2AC14
1 |
USP16 deubiquitinates H2AC14 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects H2AC12
1 |
USP16 deubiquitinates H2AC12 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects H2AC1
1 |
USP16 deubiquitinates H2AC1 on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP16 affects H2A-DUB
| 1
USP16 inhibits H2A-DUB. 1 / 1
| 1
reach
"Immunodepletion of USP16 from a purified fraction also depleted H2A-DUB activity."
18226187
USP16 affects H2A ubiquitylation
| 1
USP16 inhibits H2A ubiquitylation. 1 / 1
| 1
eidos
"Depletion of USP16 increases H2A ubiquitylation and restores the otherwise repressed transcription at DNA damage sites ."
31164001
USP16 affects H1-5
1 |
H1-5 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
30021884
USP16 affects GSN
| 1
TBX3 binds HOXD11, GSN, and USP16. 1 / 1
| 1
sparser
"As shown in xref , Usp16 binding to promoter regions of Tbx3, HoxD11, and Gsn genes, which are activated during Usp16 +/+ ESC differentiation, were significantly reduced in Usp16 −/− EBs as compared to Usp16 +/+ EBs."
24784029
USP16 affects GATA6
| 1
USP16 increases the amount of GATA6. 1 / 1
| 1
reach
"As shown in XREF_FIG, expression of the Igf2, Vimentin, Gata4, Gata6, and Foxa2 genes was significantly increased in EBs formed from Usp16 -/- ESCs rescued by wild-type Usp16."
24784029
USP16 affects GATA4
| 1
USP16 increases the amount of GATA4. 1 / 1
| 1
reach
"As shown in XREF_FIG, expression of the Igf2, Vimentin, Gata4, Gata6, and Foxa2 genes was significantly increased in EBs formed from Usp16 -/- ESCs rescued by wild-type Usp16."
24784029
USP16 affects G0S2
1 |
G0S2 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP16 affects FOXA2
| 1
USP16 increases the amount of FOXA2. 1 / 1
| 1
reach
"As shown in XREF_FIG, expression of the Igf2, Vimentin, Gata4, Gata6, and Foxa2 genes was significantly increased in EBs formed from Usp16 -/- ESCs rescued by wild-type Usp16."
24784029
USP16 affects FBXO11
1 |
USP16 binds FBXO11. 1 / 1
1 |
biogrid
No evidence text available
21090589
USP16 affects FBXL6
1 |
FBXL6 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
37267103
USP16 affects FAP
| 1
USP16 increases the amount of FAP. 1 / 1
| 1
isi
"CLL-Exo treatment up-regulated miR-146a and down-regulated expression of CAF markers (alpha-SMA and FAP) and USP16."
32770182
USP16 affects ESR1
1 |
ESR1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
26389696
USP16 affects EED
| 1
USP16 binds EED. 1 / 1
| 1
sparser
"Histone H2AK119 monoubiquitination (H2AK119Ub), a well-established hallmark in transcription repression, is dynamically regulated by the opposing activities of Polycomb repressive complex 1 (PRC1) and nucleosome deubiquitinases including the primary human USP16 and Polycomb repressive deubiquitinase (PR-DUB) complex."
38918638
USP16 affects DUB IKKbeta
| 1
USP16 activates DUB IKKbeta. 1 / 1
| 1
eidos
"USP16 mediated DUB of IKKbeta directly , while the USP16CI mutant lost its ability to regulate IKKbeta ubiquitination , as suggested by in vitro DUB assays ( Fig. 4G ) ."
| PMC
USP16 affects DSB repair
| 1
USP16 inhibits DSB repair. 1 / 1
| 1
reach
"USP16 pairs with HERC2 to remove H2A K15 linked ubiquitin conjugates and downregulate DSB repair whereas its ohnolog, USP45, has no known involvements in the DNA damage response."
28177072
USP16 affects DNAJC2
1 |
DNAJC2 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33957083
USP16 leads to the ubiquitination of DNA Breaks, Double-Stranded. 1 / 1
| 1
reach
"Thus far, USP16 dependent reduction of H2A ubiquitylation and derepression of DSB induced transcription silencing is revealed, although whether USP16 directly deubiquitylates H2A is not clear [43]."
28764946
USP16 affects DBT
1 |
USP16 binds DBT. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP16 affects Cluh
1 |
Cluh binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35012549
USP16 affects CUL3
| 1
USP16 inhibits CUL3. 1 / 1
| 1
reach
"Here, we showed that Usp16 antagonizes the activity of CUL3 based ubiquitin ligase by deubiquitinating Plk1, which not only promotes the localization of Plk1 to the kinetochores but also retains Plk1 there until metaphase."
26323689
USP16 affects CSNK1D
1 |
CSNK1D binds USP16. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP16 affects CHAF1A
| 1
USP16 activates CHAF1A. 1 / 1
| 1
reach
"USP16 was confirmed as a direct target of miR-146a and USP16 overexpression in BM-MSCs abrogated the CLL-Exo-mediated up-regulation of CAF markers."
32770182
USP16 affects CDKN1A
| 1
USP16 activates CDKN1A. 1 / 1
| 1
eidos
"Accordingly , the expression of p21 and Clusterin as senescence markers was induced by the depletion of lncEPAT but reversed by depletion of USP16 ( Fig. 7H ) ."
36197973
USP16 affects CCNF
1 |
CCNF binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36114006
USP16 affects CALM1
1 |
CALM1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
15840729
USP16 affects BYSL
1 |
BYSL binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
USP16 affects BMI1
| 1
USP16 binds BMI1 and HOXD10. 1 / 1
| 1
sparser
"ChIP studies on HOXD10 binding of USP16 and the BMI1 subunit of PRC1 found both proteins are localized to the HOXD10 promoter, yet H2A was not ubiquitinated unless USP16 was depleted."
23845989
USP16 affects BCL2L1
| 1
USP16 decreases the amount of BCL2L1. 1 / 1
| 1
reach
"In accordance with this observation, we also found that knockdown of USP16 decreased P21 but increased Bcl-XL and Bcl -2 expression in liver tumour cells."
27633997
USP16 affects BCL2
| 1
USP16 decreases the amount of BCL2. 1 / 1
| 1
reach
"In accordance with this observation, we also found that knockdown of USP16 decreased P21 but increased Bcl-XL and Bcl -2 expression in liver tumour cells."
27633997
USP16 affects BAP1
| 1
BAP1 binds USP16. 1 / 1
| 1
sparser
"Interestingly, we also observed an overlap in the genomic binding of BAP1 and another well-known H2AK119ub-deubiquitinase USP16 ( xref , xref ), suggesting their cooperative or complementary functions."
38529289
USP16 affects AXIN2 mRNA
| 1
USP16 inhibits AXIN2 mRNA. 1 / 1
| 1
eidos
"Fig. S4B ) , we noticed that downregulation of USP16 increased AXIN2 mRNA induction three-fold compared to cells transfected with a control siRNA ( P < 0.05 ) ( Fig. 2f ) ."
30504774
USP16 affects ANLN
1 |
ANLN binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36526897
USP16 affects AHNAK
1 |
AHNAK binds USP16. 1 / 1
1 |
biogrid
No evidence text available
34535262
USP1 affects USP16
| 1
USP1 activates USP16. 1 / 1
| 1
reach
"In addition, DUBs involved in DNA damage signaling are USP1 that targets PCNA (proliferating cell nuclear antigen) [76], FANCD2 and FANCI (the Fanconi anemia proteins) [93,94], and USP3 and USP16 that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21763684
UBP8 affects USP16
| 1
UBP8 ubiquitinates USP16. 1 / 1
| 1
reach
"For example, Ubp8 and Ubp10 target ubiquitinated H2B, and BAP1 and USP16, among others, remove ubiquitin from H2A (Scheuermann et al., 2010; Weake and Workman, 2008)."
28178526
UBP10 affects USP16
| 1
UBP10 ubiquitinates USP16. 1 / 1
| 1
reach
"For example, Ubp8 and Ubp10 target ubiquitinated H2B, and BAP1 and USP16, among others, remove ubiquitin from H2A (Scheuermann et al., 2010; Weake and Workman, 2008)."
28178526
UBE3A affects USP16
1 |
UBE3A binds USP16. 1 / 1
1 |
biogrid
No evidence text available
22645313
UBD affects USP16
1 |
USP16 binds UBD. 1 / 1
1 |
biogrid
No evidence text available
21090589
TXNL1 affects USP16
1 |
TXNL1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
22939629
TSR1 affects USP16
1 |
TSR1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
TRIM67 affects USP16
1 |
TRIM67 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36215168
TNF affects USP16
| 1
TNF increases the amount of USP16. 1 / 1
| 1
reach
"Furthermore, LPS and TNFalpha, strong activators of the NFkappaB pathway, upregulated the USP16 transcription."
31888715
TKT affects USP16
1 |
TKT binds USP16. 1 / 1
1 |
biogrid
No evidence text available
40593561
TIPARP affects USP16
1 |
TIPARP binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35439318
THAP1 affects USP16
1 |
THAP1 decreases the amount of USP16. 1 / 1
1 |
bel
"Table 1. Genes regulated after ectopic expression of THAP1 in endothelial cells Genes down-regulated after ectopic expression of THAP1 in primary ECs"
17003378
TBX3 affects USP16
| 1
TBX3 binds HOXD11, GSN, and USP16. 1 / 1
| 1
sparser
"As shown in xref , Usp16 binding to promoter regions of Tbx3, HoxD11, and Gsn genes, which are activated during Usp16 +/+ ESC differentiation, were significantly reduced in Usp16 −/− EBs as compared to Usp16 +/+ EBs."
24784029
Smoke affects USP16
1 |
Smoke decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
34520756
SUZ12 affects USP16
1 |
SUZ12 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
27634302
STAU1 affects USP16
1 |
STAU1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36232890
SRPRB affects USP16
1 |
SRPRB binds USP16. 1 / 1
1 |
biogrid
No evidence text available
28514442
SOST affects USP16
1 |
SOST binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33961781
SEC24A affects USP16
1 |
SEC24A binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
SEC23A affects USP16
1 |
SEC23A binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
SATB1 affects USP16
1 |
USP16 binds SATB1. 1 / 1
1 |
biogrid
No evidence text available
35914814
RPS20 affects USP16
1 |
RPS20 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
34079125
RPS16 affects USP16
1 |
RPS16 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
RPS11 affects USP16
1 |
RPS11 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
RPLP0 affects USP16
| 1
RLP24 binds RPLP0 and USP16. 1 / 1
| 1
sparser
"The absence of the 60S trans-acting factor RLP24 and the ribosomal protein RPL23a/uL23 further confirmed that USP16 specifically binds to 40S precursors."
32129764
RNF112 affects USP16
1 |
RNF112 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
40178292
RLP24 affects USP16
| 1
RLP24 binds RPLP0 and USP16. 1 / 1
| 1
sparser
"The absence of the 60S trans-acting factor RLP24 and the ribosomal protein RPL23a/uL23 further confirmed that USP16 specifically binds to 40S precursors."
32129764
RACK1 affects USP16
1 |
RACK1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
Plk1 and/or CDK1 affects USP16
| 1
Plk1 and/or CDK1 phosphorylates USP16. 1 / 1
| 1
rlimsp
"(B) Coomassie blue staining of Usp16 fragment 150–600 phosphorylated by Plk1 and/or CDK1."
26323689
Plant Extracts affects USP16
1 |
Plant Extracts increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
23557933
PTOV1 affects USP16
1 |
USP16 binds PTOV1. 1 / 1
1 |
biogrid
No evidence text available
21090589
PRC1 affects USP16
| 1
USP16 binds PRC1. 1 / 1
| 1
sparser
"Functionally, PRC1–USP16 activity is essential for mitochondrial morphology, respiration, and proteome stability."
41597171
PPL affects USP16
1 |
PPL binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33961781
PPIA affects USP16
1 |
USP16 binds PPIA. 1 / 1
1 |
biogrid
No evidence text available
38334954
PLEKHA4 affects USP16
1 |
PLEKHA4 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
31091453
PBD affects USP16
| 1
USP16 binds PBD. 1 / 1
| 1
reach
"Examination of the GST pull-down complexes showed that Usp16 specifically interacted with the wild-type (WT) PBD but not the PBD2A mutant (XREF_FIG), indicating that the interaction between Plk1 and Usp16 is PBD dependent."
26323689
PAX6 affects USP16
1 |
USP16 binds PAX6. 1 / 1
1 |
biogrid
No evidence text available
35914814
PAK1 affects USP16
1 |
PAK1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
OSCP1 affects USP16
1 |
USP16 binds OSCP1. 1 / 1
1 |
biogrid
No evidence text available
33961781
NR2C2 affects USP16
1 |
NR2C2 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
30463901
NLRP3 affects USP16
| 1
USP16 binds NLRP3. 1 / 1
| 1
sparser
"Mechanically, USP16 directly binds to the NLRP3 protein to eliminate K48 ubiquitination modification, enhancing the stability of the NLRP3 protein, activating inflammasome activity."
41591834
NANOG affects USP10, USP16, USP3, USP37, USP44, and USP7
| 1
USP10 binds USP16, USP3, USP37, USP44, USP7, and NANOG. 1 / 1
| 1
sparser
"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."
26880980
NAA40 affects USP16
1 |
NAA40 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33916271
N affects USP16
1 |
N binds USP16. 1 / 1
1 |
biogrid
No evidence text available
| DOI
MYC affects Flag
| 1
USP16 binds MYC and Flag. 1 / 1
| 1
sparser
"To identify whether USP16 serves as a DUB of c-Myc, HEK293T cells were transfected with plasmids encoding HA-ubiquitin and Flag-c-Myc with wild-type USP16 or its catalytically inactive mutant USP16-C205S and treated with MG132."
33546726
MIR320A affects USP16
1 |
MIR320A decreases the amount of USP16. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
MAD1L1 affects USP16
1 |
USP16 binds MAD1L1. 1 / 1
1 |
biogrid
No evidence text available
35831314
LRRC59 affects USP16
1 |
LRRC59 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
32788342
LINC02381 affects USP16
1 |
LINC02381 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36197973
LDLR affects USP16
| 1
USP16 binds LDLR. 1 / 1
| 1
sparser
"Co-immunoprecipitation revealed that USP16 interacts with LDLR and deubiquitinates the receptor, thus protecting it against degradation ( xref J)."
36980227
In vitro affects USP16
| 1
In vitro phosphorylates USP16. 1 / 1
| 1
rlimsp
"(H, left) In vitro phosphorylation of Usp16 by Plk1."
26323689
ILF3 affects USP16
1 |
ILF3 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
IKBKG affects IKBKB
| 1
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
biogrid
No evidence text available
28855339
HSPD1 affects USP16
1 |
HSPD1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
30021884
HOXD11 affects USP16
| 1
TBX3 binds HOXD11, GSN, and USP16. 1 / 1
| 1
sparser
"As shown in xref , Usp16 binding to promoter regions of Tbx3, HoxD11, and Gsn genes, which are activated during Usp16 +/+ ESC differentiation, were significantly reduced in Usp16 −/− EBs as compared to Usp16 +/+ EBs."
24784029
HOXD10 affects USP16
| 1
USP16 binds BMI1 and HOXD10. 1 / 1
| 1
sparser
"ChIP studies on HOXD10 binding of USP16 and the BMI1 subunit of PRC1 found both proteins are localized to the HOXD10 promoter, yet H2A was not ubiquitinated unless USP16 was depleted."
23845989
HGS affects USP16
1 |
HGS binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
HDLBP affects USP16
1 |
HDLBP binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35831314
HDAC1 affects USP16
1 |
HDAC1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
40437099
HBxDelta35 affects USP16
| 1
HBxDelta35 inhibits USP16. 1 / 1
| 1
reach
"Thus, these data indicate that the downregulation of USP16 by HBxDelta35 may contribute to the stemness properties of liver tumour cells."
27633997
H4C16 affects USP16
1 |
USP16 binds H4C16. 1 / 1
1 |
biogrid
No evidence text available
21090589
H2BC3 affects USP16
1 |
USP16 binds H2BC3. 1 / 1
1 |
biogrid
No evidence text available
24013421
H2BC13 affects USP16
1 |
USP16 binds H2BC13. 1 / 1
1 |
biogrid
No evidence text available
19615732
H2BC12 affects USP16
1 |
H2BC12 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
34349018
H2BC10 affects USP16
1 |
H2BC10 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
34349018
H2AZ1 affects USP16
1 |
USP16 binds H2AZ1. 1 / 1
1 |
biogrid
No evidence text available
21245042
H2AC20 affects USP3
| 1
USP3 binds USP16 and H2AC20. 1 / 1
| 1
sparser
"Both USP3 and USP16 are also associated with H2A deubiquitination following DNA damage processing [ xref , xref ]."
20974139
H2AC19 affects USP16
1 |
USP16 binds H2AC19. 1 / 1
1 |
biogrid
No evidence text available
17914355
H1-5 affects USP16
1 |
H1-5 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
30021884
GSN affects USP16
| 1
TBX3 binds HOXD11, GSN, and USP16. 1 / 1
| 1
sparser
"As shown in xref , Usp16 binding to promoter regions of Tbx3, HoxD11, and Gsn genes, which are activated during Usp16 +/+ ESC differentiation, were significantly reduced in Usp16 −/− EBs as compared to Usp16 +/+ EBs."
24784029
G0S2 affects USP16
1 |
G0S2 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33961781
Flag affects MYC, and USP16
| 1
USP16 binds MYC and Flag. 1 / 1
| 1
sparser
"To identify whether USP16 serves as a DUB of c-Myc, HEK293T cells were transfected with plasmids encoding HA-ubiquitin and Flag-c-Myc with wild-type USP16 or its catalytically inactive mutant USP16-C205S and treated with MG132."
33546726
FR900359 affects USP16
1 |
FR900359 phosphorylates USP16. 1 / 1
1 |
ctd
No evidence text available
37730182
FGF18 affects USP16
| 1
FGF18 decreases the amount of USP16. 1 / 1
| 1
reach
"Mechanistically, FGF18 treatment reduces the levels of ubiquitin carboxyl-terminal hydrolase 16 (USP16), leading to increased ubiquitination levels of Kelch Like ECH Associated Protein 1 (KEAP1) and the activation of nuclear factor erythroid 2-related factor 2 (Nrf2)."
37777507
FBXO11 affects USP16
1 |
USP16 binds FBXO11. 1 / 1
1 |
biogrid
No evidence text available
21090589
FBXL6 affects USP16
1 |
FBXL6 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
37267103
FAP affects USP16
| 1
FAP increases the amount of USP16. 1 / 1
| 1
isi
"CLL-Exo treatment up-regulated miR-146a and down-regulated expression of CAF markers (alpha-SMA and FAP) and USP16."
32770182
Enzyme Inhibitors affects USP16
1 |
Enzyme Inhibitors inhibits USP16. 1 / 1
1 |
ctd
No evidence text available
23301498
ESR1 affects USP16
1 |
ESR1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
26389696
EED affects USP16
| 1
USP16 binds EED. 1 / 1
| 1
sparser
"Histone H2AK119 monoubiquitination (H2AK119Ub), a well-established hallmark in transcription repression, is dynamically regulated by the opposing activities of Polycomb repressive complex 1 (PRC1) and nucleosome deubiquitinases including the primary human USP16 and Polycomb repressive deubiquitinase (PR-DUB) complex."
38918638
Dronabinol affects USP16
1 |
Dronabinol decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
30283037
Dietary Fats affects USP16
1 |
Dietary Fats increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
28946194
DNAJC2 affects USP16
1 |
DNAJC2 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
33957083
DBT affects USP16
1 |
USP16 binds DBT. 1 / 1
1 |
biogrid
No evidence text available
19615732
Cyclin affects USP16
| 1
Cyclin phosphorylates USP16. 1 / 1
| 1
reach
"During the cell cycle, Ubp-M is sequentially phosphorylated and dephosphorylated, potentially by the cdc-2/cyclin B complex, which phosphorylates Ubp-M in vitro ( Cai et al., 1999 )."
18374642
Ct-HBX proteins affects USP16
| 1
Ct-HBX proteins inhibits USP16. 1 / 1
| 1
reach
"These results indicate that USP16 inhibition by Ct-HBX proteins may provide growth advantages for liver tumour cells in vivo."
27633997
Cluh affects USP16
1 |
Cluh binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35012549
Carboxyl-terminal Truncated HBx affects USP16
| 1
Carboxyl-terminal Truncated HBx inhibits USP16. 1 / 1
| 1
reach
"USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells."
27633997
CSNK1D affects USP16
1 |
CSNK1D binds USP16. 1 / 1
1 |
biogrid
No evidence text available
22939629
CHUK affects IKBKG, and USP16
| 1
CHUK binds IKBKG and USP16. 1 / 1
| 1
sparser
"IKKα and IKKβ contain similar functional domains; thus, we further evaluated the interaction of USP16 with IKKα and NEMO."
| PMC
CHUK affects IKBKB, IKBKG, and USP16
| 1
USP16 binds IKBKG, IKBKB, and CHUK. 1 / 1
| 1
sparser
"Depletion of the NBD disrupted the interaction of USP16 with both IKKβ and IKKα ( xref ), which further suggests that USP16 and NEMO may competitively bind to IKKβ and IKKα."
| PMC
CEP78 affects USP16
| 1
CEP78 activates USP16. 1 / 1
| 1
eidos
"( A ) Western blotting showed that CEP78 down-regulation decreased the USP16 expression ."
36206347
CCNF affects USP16
1 |
CCNF binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36114006
CALM1 affects USP16
1 |
CALM1 binds USP16. 1 / 1
1 |
biogrid
No evidence text available
15840729
BYSL affects USP16
1 |
BYSL binds USP16. 1 / 1
1 |
biogrid
No evidence text available
35271311
BRCC36 affects OTUB1, PSMD14, RNF8, USP16, and USP3
| 1
USP3 binds USP16, BRCC36, PSMD14, OTUB1, and RNF8. 1 / 1
| 1
sparser
"The DUBs USP3, USP16, BRCC36, POH1, and OTUB1 are associated with negative regulation of the RNF8 pathway, with USP3 and USP16 being first linked to this pathway through their ability to oppose H2A ub[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23416108
BMI1 affects USP16
| 1
USP16 binds BMI1 and HOXD10. 1 / 1
| 1
sparser
"ChIP studies on HOXD10 binding of USP16 and the BMI1 subunit of PRC1 found both proteins are localized to the HOXD10 promoter, yet H2A was not ubiquitinated unless USP16 was depleted."
23845989
BAP1 affects USP16
| 1
BAP1 binds USP16. 1 / 1
| 1
sparser
"Interestingly, we also observed an overlap in the genomic binding of BAP1 and another well-known H2AK119ub-deubiquitinase USP16 ( xref , xref ), suggesting their cooperative or complementary functions."
38529289
ANLN affects USP16
1 |
ANLN binds USP16. 1 / 1
1 |
biogrid
No evidence text available
36526897
AHNAK affects USP16
1 |
AHNAK binds USP16. 1 / 1
1 |
biogrid
No evidence text available
34535262
3-methylcholanthrene increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
18804290
3-hydroxyisovaleric acid increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
24124592
3-chloropropane-1,2-diol increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
34915118
2-hydroxypropanoic acid decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
30851411
17alpha-ethynylestradiol increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
23129252
1,2-dimethylhydrazine decreases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
22206623
4,4'-sulfonyldiphenol increases the amount of USP16. 1 / 1
1 |
ctd
No evidence text available
39298647