IndraLab
Statements
sparser
"To assess whether USP7 and USP11 associate with bona fide PRC1 complexes, nuclear extracts from FDFs ( xref ) and 293T cells (not shown) were subjected to size exclusion chromatography on a Superose 6 10/300 column, and individual fractions were analysed by SDS–PAGE and immunoblotting."
USP11 binds USP7 and polycomb-group protein. 1 / 1
|
1
eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
sparser
"Previous studies have demonstrated that there is the possibility that USP11 and NONO may interact with each other. xref In order to ascertain the hypothesis, we transfected Flag‐USP11 and Myc‐NONO into HEK293 cells, collected total proteins and used the antibodies against Flag/Myc and the isotype‐matched control IgGs to perform coimmunoprecipitation (co‐IP)."
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
reach
"Further, rescue experiments were conducted invivo to validate the function of the USP11/p53/KLF2/NF-kappaB axis in ICH induced inflammation, which confirmed that USP11 silencing blocked the release of pro inflammatory cytokines following ICH by downregulating p53, thus protecting against neurological impairment."
reach
"In addition, expression of wild-type XIAP leads to the inhibition of anoikis, we observed that disruption of interaction between XIAP and USP11 by expression of XIAP L207P mutant (interaction deficient) significantly attenuates the inhibition of anoikis by XIAP (Supplemental Fig. 6)."
sparser
"To validate the impact of Cys203 and Leu207 as well as Lys206 on XIAP in mediating the interaction of XIAP with USP11, we performed a multiple sequence alignment at that particular region (residues 200–210), using the aligned the amino acid stretch from 200 to 210 of human XIAP with mouse, rat and xenopus XIAP sequences as well as the human CIAP1 and CIAP2."
reach
"While we have identified the critical role of UPS11 in mammary tumorigenesis and further dissected the mechanism by which USP11 catalyzes XIAP for deubiquitylation, the mechanism that initiates the accumulation of USP11 in breast cancer tissue and its subsequent regulation during the tumor development still remains unknown."
sparser
"We observed a slight increase in SPRTN-USP11 interaction following treatment with etoposide (VP16), a TOP2 crosslinking agent ( xref D , xref ), camptothecin (CPT), TOP1 cross-linking agent, formaldehyde (nonspecific cross-linking agent), and hydroxyurea (non-cross-linking agent) ( xref )."
sparser
"Co-immunoprecipitation (Co-IP) of Myc-USP11 with SFB-SPRTN full-length (FL) or ΔSprT, ΔSH, ΔPIP, ΔUBZ, E112A catalytic inactive, and Y117C (SPRTN mutation identified in RJALS patients) mutant constructs showed that SPRTN-USP11 interaction was lost with deletion of the N-terminal SprT domain of SPRTN ( xref A )."
reach
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin induced inflammatory lung injury."
sparser
"LPA1 is associated with USP11 in quiescent cells, while LPA treatment triggers LPA1 dis-association with USP11 and in turn binding to Nedd4L. Knockdown or inhibition of USP11 reduces LPA1 stability, levels of LPA1, and LPA1-CD14 interaction complex; thereby diminishing both LPA- and LPS-induced inflammatory responses and lung injury in preclinical murine models."
sparser
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin-induced inflammatory lung injury."
USP11 affects cell population proliferation
|
1
19
USP11 activates cell population proliferation.
|
1
12
USP11 inhibits cell population proliferation.
|
7
reach
"In addition, expression of wild-type XIAP leads to the inhibition of anoikis, we observed that disruption of interaction between XIAP and USP11 by expression of XIAP L207P mutant (interaction deficient) significantly attenuates the inhibition of anoikis by XIAP (Supplemental Fig. 6)."
sparser
"To validate the impact of Cys203 and Leu207 as well as Lys206 on XIAP in mediating the interaction of XIAP with USP11, we performed a multiple sequence alignment at that particular region (residues 200–210), using the aligned the amino acid stretch from 200 to 210 of human XIAP with mouse, rat and xenopus XIAP sequences as well as the human CIAP1 and CIAP2."
USP11 is modified
9
|
8
1
reach
"25
,
26
,
27
Recently, USP11 was shown to promote HCC development,
28
but the underlying molecular mechanisms involved in this pathogenic process remain poorly understood.In this study, we used a proteomic approach to identify KLF4‐interacting DUBs and firstly discovered that USP11 was responsible for deubiquitinating KLF4 in HCC cells."
reach
"Since USP11 has been previously reported as an oncogene in HCC, but its underlying molecular mechanisms in hepatic disease are not entirely understood, we decided to further explore its activity as KLF4‐binding partner.We started by assessing the interaction between KLF4 and USP11 through co‐immunoprecipitation (co‐IP) analysis in transfected HEK293 cells."
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability: USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C(MMC) regulates the stability of BRCA2 in a USP11-dependent manner [117]."
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
sparser
"Previous studies have demonstrated that there is the possibility that USP11 and NONO may interact with each other. xref In order to ascertain the hypothesis, we transfected Flag‐USP11 and Myc‐NONO into HEK293 cells, collected total proteins and used the antibodies against Flag/Myc and the isotype‐matched control IgGs to perform coimmunoprecipitation (co‐IP)."
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
USP11 decreases the amount of USP11.
|
2
USP11 deubiquitinates USP11.
|
3
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability: USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C(MMC) regulates the stability of BRCA2 in a USP11-dependent manner [117]."
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
USP11 activates USP11.
|
2
USP11 inhibits USP11.
|
1
"PALB2 ubiquitylation suppresses its interaction with BRCA1 and is counteracted by the deubiquitylase USP11"
reach
"These mechanisms might be of therapeutic importance in cancer, because defective HR renders cells susceptible to inhibition of base excision repair (BER) mediated by poly (ADP-ribose) polymerase 1 (PARP1) XREF_BIBR - XREF_BIBR : the deubiquitylating enzyme (DUB) ubiquitin carboxyl-terminal hydrolase 11 (USP11) deubiquitylates partner and localizer of BRCA2 (PALB2) during S and G2 phases following DNA damage, allowing the formation of the BRCA1, PALB2, and BRCA2 complex and HR repair to advance in these phases of the cell cycle 64."
USP11 affects Neoplasm Metastasis
|
1
10
USP11 activates Neoplasm Metastasis. 10 / 11
|
1
10
reach
"USP11 promotes colorectal cancer growth and metastasis by stabilizing PPP1CA, activating the ERK/MAPK pathway, and insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) signaling (151), and interacting with nuclear factor 90 (NF90) to promote HCC proliferation and metastasis (152)."
sparser
"Co-immunoprecipitation (Co-IP) of Myc-USP11 with SFB-SPRTN full-length (FL) or ΔSprT, ΔSH, ΔPIP, ΔUBZ, E112A catalytic inactive, and Y117C (SPRTN mutation identified in RJALS patients) mutant constructs showed that SPRTN-USP11 interaction was lost with deletion of the N-terminal SprT domain of SPRTN ( xref A )."
sparser
"We next confirmed deubiquitination of monoubiquitinated SPRTN by performing deubiquitination assays in HEK 293T cells expressing SFB-SPRTN either alone or in combination with Myc-USP11 FL or C318S mutant ( xref C ) and SFB-SPRTN and HA-Ub constructs expressed either alone or in combination with Myc-USP11 FL and C318S mutant ( xref A )."
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
EGFR-vIII affects USP11
|
11
EGFR-vIII increases the amount of USP11.
|
4
EGFR-vIII decreases the amount of USP11.
|
4
EGFR-vIII inhibits USP11.
|
2
reach
"In addition, EGFR-vIII enhanced silencing of the USP11 promoter through the PI3K/AKT-HDAC1/2 axis.A dynamic balance between histone acetylation and deacetylation is maintained to regulate gene expression appropriately; a disturbance in this balance in cancer though altered gene expression can accelerate cell cycle progression [47]."
EGFR-vIII activates USP11.
|
1
Mitoxantrone affects USP11
|
5
4
sparser
"cDNAs encoding Myc-tagged forms of USP4, USP11, Ataxin-3 and A20 were gifts from Dr P.J. Lehner (University of Cambridge, UK) (51), Dr J. Yang (Baylor College of Medicine, Houston, USA) (52), Dr E.A. Fon (Montreal Neurological Institute, Canada) (23) and Dr K. Li (University of Texas Medical Branch, Galveston, USA) (53), respectively."
sparser
"cDNAs encoding Myc-tagged forms of USP4, USP11, Ataxin-3 and A20 were gifts from Dr P.J. Lehner (University of Cambridge, UK) (51), Dr J. Yang (Baylor College of Medicine, Houston, USA) (52), Dr E.A. Fon (Montreal Neurological Institute, Canada) (23) and Dr K. Li (University of Texas Medical Branch, Galveston, USA) (53), respectively."
reach
"In summary, our study identifies the functions of Usp11 mediated Sox11 stabilization in cortical development, provides an explanation for the association of Usp11 mutation with neurological disorder, and highlights the importance of deubiquitination triggered protein stabilization in the developmental process."
USP11 affects Nucleoproteins
|
5
5
USP11 binds Nucleoproteins.
|
2
5
USP11 deubiquitinates Nucleoproteins.
|
3
sparser
"We observed a slight increase in SPRTN-USP11 interaction following treatment with etoposide (VP16), a TOP2 crosslinking agent ( xref D , xref ), camptothecin (CPT), TOP1 cross-linking agent, formaldehyde (nonspecific cross-linking agent), and hydroxyurea (non-cross-linking agent) ( xref )."
sparser
"Co-immunoprecipitation (Co-IP) of Myc-USP11 with SFB-SPRTN full-length (FL) or ΔSprT, ΔSH, ΔPIP, ΔUBZ, E112A catalytic inactive, and Y117C (SPRTN mutation identified in RJALS patients) mutant constructs showed that SPRTN-USP11 interaction was lost with deletion of the N-terminal SprT domain of SPRTN ( xref A )."
sparser
"Knockdown of USP11 results in the activation of DNA damage-response pathways, leading to hypersensitivity of cells to genotoxic stress ( xref ); (iii) in primary human fibroblasts knockdown of USP11 results in characteristics of senescence, including proliferative arrest and enlarged nucleoli ( xref ); and (iv) USP11 interacts with p21 to regulate cell cycle progression and DNA damage responses ( xref )."
MiR-132-3p affects USP11
|
1
7
EIF affects USP11
|
8
sparser
"One novel potential lymphoma-associated driver of eIF4B is fatty acid synthase (FASN) which stabilizes eIF4B and increase expression of oncoproteins such as MYC, BCL6 and MCL1 (a BCL2-related anti-apoptotic protein) via formation of a complex between eIF4B and the deubiquitinase USP11 in DLBCL cells [ xref ]."
reach
"As reflected by western blot and qRT-PCR assays, USP11 knockdown led to upregulated expression of KLF2, as well as downregulated levels of NF-κB (p65), its phosphorylation (p-p65), and downstream markers of the NF-κB pathway (cyclinD1, c-myc) in the brain tissues of rats with ICH-like symptoms; these effects of USP11 knockdown alone could be reversed by its combination with either p53 overexpression or KLF2 knockdown (Figure 5A)."
Nucleoproteins affects USP11
|
3
5
Nucleoproteins binds USP11.
|
2
5
Nucleoproteins deubiquitinates USP11.
|
1
Nucleoproteins deubiquitinates USP11. 1 / 1
|
1
reach
"In line with this notion, we showed that mouse Usp11 was repressed by the Notch and Hes1 axis, as overexpression of an active form of Notch (Notch intracellular domain, referred to as NIC) or Hes1 in a neuroblastoma cell line N2a diminished Usp11 expression and the promoter activity of Usp11 gene."
reach
"In line with this notion, we showed that mouse Usp11 was repressed by the Notch and Hes1 axis, as overexpression of an active form of Notch (Notch intracellular domain, referred to as NIC) or Hes1 in a neuroblastoma cell line N2a diminished Usp11 expression and the promoter activity of Usp11 gene."
FK228 affects USP11
|
8
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"Previous studies have demonstrated that there is the possibility that USP11 and NONO may interact with each other. xref In order to ascertain the hypothesis, we transfected Flag‐USP11 and Myc‐NONO into HEK293 cells, collected total proteins and used the antibodies against Flag/Myc and the isotype‐matched control IgGs to perform coimmunoprecipitation (co‐IP)."
sparser
"To elucidate the underlying mechanism by which USP11 regulates the protein levels of NONO, Flag‐USP11 plasmid or control vector was introduced into SK‐Mel‐28 and A375, after 24 h, MG132 was added into the medium to inhibit the proteasome activity followed by the NONO examination."
USP11 affects 5-formyluracil
|
7
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
reach
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin induced inflammatory lung injury."
sparser
"LPA1 is associated with USP11 in quiescent cells, while LPA treatment triggers LPA1 dis-association with USP11 and in turn binding to Nedd4L. Knockdown or inhibition of USP11 reduces LPA1 stability, levels of LPA1, and LPA1-CD14 interaction complex; thereby diminishing both LPA- and LPS-induced inflammatory responses and lung injury in preclinical murine models."
sparser
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin-induced inflammatory lung injury."
sparser
"Previous studies have demonstrated that there is the possibility that USP11 and NONO may interact with each other. xref In order to ascertain the hypothesis, we transfected Flag‐USP11 and Myc‐NONO into HEK293 cells, collected total proteins and used the antibodies against Flag/Myc and the isotype‐matched control IgGs to perform coimmunoprecipitation (co‐IP)."
sparser
"To elucidate the underlying mechanism by which USP11 regulates the protein levels of NONO, Flag‐USP11 plasmid or control vector was introduced into SK‐Mel‐28 and A375, after 24 h, MG132 was added into the medium to inhibit the proteasome activity followed by the NONO examination."
USP11 affects translation
|
6
USP11 affects MGL
|
6
MGL affects USP11
|
6
5-formyluracil affects USP11
|
6
5-formyluracil inhibits USP11.
|
3
5-formyluracil increases the amount of USP11.
|
2
5-formyluracil activates USP11.
|
1
5-formyluracil activates USP11. 1 / 1
|
1
USP11 affects viral RNA replication
|
5
eidos
"When cellular USP11 was knocked down , the amounts of vRNA and cRNA of the wild-type virus increased by about 2.5-fold ( Figure 7A , lane 1 versus lanes 2 and 3 ) , indicating that USP11 inhibits viral RNA replication as previously mentioned ; with the mutant virus defective in NP ubiquitination ( K184R ) , however , there was no significant difference in viral RNA synthesis between USP11 knockdown and control cells ( Figure 7A , lanes 4-6 ) ."
USP11 affects ferroptosis
|
1
4
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
USP11 affects RNA replication
|
5
USP11 inhibits RNA replication. 5 / 5
|
5
reach
"When cellular USP11 was knocked down, the amounts of vRNA and cRNA of the wild-type virus increased by about 2.5-fold ( Figure 7A, lane 1 versus lanes 2 and 3) , indicating that USP11 inhibits viral RNA replication as previously mentioned; with the mutant virus defective in NP ubiquitination (K184R), however, there was no significant difference in viral RNA synthesis between USP11 knockdown and control cells ( Figure 7A, lanes 4-6) ."
reach
"This result further supports the conclusion that USP11 inhibits viral RNA replication through deubiquitinating NP.Ubiquitination is a posttranslational modification, in which ubiquitin chains or single ubiquitin molecules are linked to target proteins, giving rise to poly-or monoubiquitination (Weissman, 2001) ."
sparser
"Notably, wild-type (WT) USP11 deubiquitinated PTEN in vivo and in vitro, whereas the catalytically inactive USP11 C318S (CS) mutant, which could still bind to PTEN, exerted a dramatically diminished ability to deubiquitinate PTEN, and even exhibited a more heavy ubiquitinating effect (Fig. xref and Supplementary Fig. xref )."
USP11 affects PB2
|
5
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
PB2 affects USP11
|
5
reach
"f, i The knockout of both HDAC1 and HDAC2 upregulated USP11 at the mRNA and protein levels in U87-vIII, U251-vIII and N9-vIII cells performed and showed that USP11 expression was downregulated at the mRNA and protein levels in U87, U251 and N9 cells upon the activation of EGFR-vIII (Fig. 5c, d) ."
reach
"f, i The knockout of both HDAC1 and HDAC2 upregulated USP11 at the mRNA and protein levels in U87-vIII, U251-vIII and N9-vIII cells performed and showed that USP11 expression was downregulated at the mRNA and protein levels in U87, U251 and N9 cells upon the activation of EGFR-vIII (Fig. 5c, d) ."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"Knockdown of USP11 results in the activation of DNA damage-response pathways, leading to hypersensitivity of cells to genotoxic stress ( xref ); (iii) in primary human fibroblasts knockdown of USP11 results in characteristics of senescence, including proliferative arrest and enlarged nucleoli ( xref ); and (iv) USP11 interacts with p21 to regulate cell cycle progression and DNA damage responses ( xref )."
Valproic acid affects USP11
4
|
reach
"However, USP11 FL features a ' burst ' phase (XREF_SUPPLEMENTARY), indicating that, in contrast to USP4 FL and USP15 FL, slow ubiquitin off-rates limit USP11 activity but the DUSP-Ubl domain is not able to promote ubiquitin release or is not efficient in doing so, in agreement with a recent publication XREF_BIBR."
USP11 affects cell cycle
|
4
USP11 inhibits cell cycle.
|
2
USP11 activates cell cycle.
|
2
USP11 affects apoptotic process
|
1
3
USP11 inhibits apoptotic process.
|
1
1
USP11 inhibits apoptotic process. 2 / 2
|
1
1
eidos
"* P < 0.05 MiR-132-3p constrains cell growth and metastasis and increases apoptosis by decreasing USP11 in colorectal cancer cells To study the function of miR-132-3p / USP11 axis on colorectal cancer progression , HCT116 and SW480 cells were transfected with miR-NC , miR-132-3p mimic , miR-132-3p mimic + pcDNA , or USP11 overexpression vector ."
USP11 activates apoptotic process.
|
2
USP11 affects TGFbeta receptor
|
4
USP11 affects Neoplasm Invasiveness
|
4
USP11 inhibits Neoplasm Invasiveness.
|
2
USP11 activates Neoplasm Invasiveness.
|
2
reach
"25
,
26
,
27
Recently, USP11 was shown to promote HCC development,
28
but the underlying molecular mechanisms involved in this pathogenic process remain poorly understood.In this study, we used a proteomic approach to identify KLF4‐interacting DUBs and firstly discovered that USP11 was responsible for deubiquitinating KLF4 in HCC cells."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"Notably, wild-type (WT) USP11 deubiquitinated PTEN in vivo and in vitro, whereas the catalytically inactive USP11 C318S (CS) mutant, which could still bind to PTEN, exerted a dramatically diminished ability to deubiquitinate PTEN, and even exhibited a more heavy ubiquitinating effect (Fig. xref and Supplementary Fig. xref )."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
Knockout HDAC1 HDAC2 affects USP11
|
3
eidos
"f , i The knockout of both HDAC1 and HDAC2 upregulated USP11 at the mRNA and protein levels in U87-vIII , U251-vIII and N9-vIII cells performed and showed that USP11 expression was downregulated at the mRNA and protein levels in U87 , U251 and N9 cells upon the activation of EGFR-vIII ( Fig. 5c , d ) ."
USP11 affects replication
|
1
2
USP11 affects p-tolyl beta-D-glucuronide
|
3
USP11 binds p-tolyl beta-D-glucuronide.
|
2
USP11 activates p-tolyl beta-D-glucuronide.
|
1
USP11 bound to p-tolyl beta-D-glucuronide activates p-tolyl beta-D-glucuronide. 1 / 1
|
1
USP11 affects melanoma cells
|
3
USP11 affects lipopolysaccharide
|
3
USP11 affects influenza A virus RNA replication
|
3
USP11 affects cell growth
|
3
USP11 affects SPRTN auto-proteolysis
|
3
USP11 CS affects USP11
|
3
PB2 affects Nucleoproteins
|
3
H2AZK4/7AC affects USP11
|
3
EGFR-vIII mutation affects USP11
|
3
P-tolyl beta-D-glucuronide affects USP11
|
2
Doxycycline affects USP11
|
2
D EGFR-VIII affects USP11
|
1
1
sparser
"cDNAs encoding Myc-tagged forms of USP4, USP11, Ataxin-3 and A20 were gifts from Dr P.J. Lehner (University of Cambridge, UK) (51), Dr J. Yang (Baylor College of Medicine, Houston, USA) (52), Dr E.A. Fon (Montreal Neurological Institute, Canada) (23) and Dr K. Li (University of Texas Medical Branch, Galveston, USA) (53), respectively."
1
|
USP11 affects resistance 5-Fu
|
2
USP11 affects resistance 5-Fluorouracil
|
2
USP11 affects protein deubiquitination
|
2
USP11 activates protein deubiquitination. 2 / 2
|
2
eidos
"100 A recent study indicated that USP7 stabilizes the Hippo pathway by deubiquitinating the transcriptional coactivator Yorkie , promoting HCC growth.101 Further , USP7 participates in lipogenesis-associated HCC progression by promoting stabilization and transcription of zinc-finger protein 638.102 USP11 is upregulated in HCC and is correlated with shorter survival in HCC patients.103 ,104 USP11 promotes HCC cell survival , invasion , and metastatic potency in vitro and in vivo.103 ,104 Mechanistically , USP11 interacts with nuclear factor 90 ( NF90 ) and promotes its deubiquitination , thereby stabilizing it in HCC cells.103 Consistent with this , USP11 expression positively correlates with NF90 expression in human HCC tissues.103 Similar to USP11 , elevated USP13 in HCC patients is associated with a poor prognosis ."
USP11 affects migration
|
2
USP11 affects miR-132-3p
|
2
USP11 affects melanoma cell
|
2
USP11 affects localization
|
2
USP11 affects influenza virus replication
|
2
USP11 affects influenza virus RNA replication
|
2
USP11 affects inflammatory response
|
2
USP11 affects cell differentiation
|
2
USP11 affects USP
|
2
reach
"As reflected by western blot and qRT-PCR assays, USP11 knockdown led to upregulated expression of KLF2, as well as downregulated levels of NF-κB (p65), its phosphorylation (p-p65), and downstream markers of the NF-κB pathway (cyclinD1, c-myc) in the brain tissues of rats with ICH-like symptoms; these effects of USP11 knockdown alone could be reversed by its combination with either p53 overexpression or KLF2 knockdown (Figure 5A)."
reach
"As reflected by western blot and qRT-PCR assays, USP11 knockdown led to upregulated expression of KLF2, as well as downregulated levels of NF-κB (p65), its phosphorylation (p-p65), and downstream markers of the NF-κB pathway (cyclinD1, c-myc) in the brain tissues of rats with ICH-like symptoms; these effects of USP11 knockdown alone could be reversed by its combination with either p53 overexpression or KLF2 knockdown (Figure 5A)."
sparser
"cDNAs encoding Myc-tagged forms of USP4, USP11, Ataxin-3 and A20 were gifts from Dr P.J. Lehner (University of Cambridge, UK) (51), Dr J. Yang (Baylor College of Medicine, Houston, USA) (52), Dr E.A. Fon (Montreal Neurological Institute, Canada) (23) and Dr K. Li (University of Texas Medical Branch, Galveston, USA) (53), respectively."
USP11 affects SUMO-ubiquitin chains
|
2
USP11 affects SPRTN deubiquitination
|
2
reach
"In conclusion, the current study emphasized the importance of the interaction of USP11 and Sirt3 in the pathological process of IVDD via regulating oxidative stress-induced ferroptosis, and USP11-mediated oxidative stress-induced ferroptosis is identified as a promising target for treating IVDD."
sparser
"In conclusion, the current study emphasized the importance of the interaction of USP11 and Sirt3 in the pathological process of IVDD via regulating oxidative stress-induced ferroptosis, and USP11-mediated oxidative stress-induced ferroptosis is identified as a promising target for treating IVDD."
USP11 affects PA
|
2
USP11 affects IKK_complex
|
2
USP11 affects H2AZK4/7AC
|
2
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
USP11 affects DNA repair
|
2
USP11 inhibits DNA repair. 2 / 2
|
2
reach
"More interestingly, whilst expression of USP11 rescued the defect in DNA repair induced by USP11 depletion, confirming the specificity of our siRNA sequences, expression of USP11-R433K could not, implying that methylation is required for USP11 to effectively function in the repair of olaparib-induced lesions (Fig. 4a, b)."
USP11 affects Colorectal Neoplasms
|
2
USP11 activates Colorectal Neoplasms. 2 / 2
|
2
USP11 affects Cell Survival
|
2
USP11 affects Carcinogenesis
|
2
sparser
"cDNAs encoding Myc-tagged forms of USP4, USP11, Ataxin-3 and A20 were gifts from Dr P.J. Lehner (University of Cambridge, UK) (51), Dr J. Yang (Baylor College of Medicine, Houston, USA) (52), Dr E.A. Fon (Montreal Neurological Institute, Canada) (23) and Dr K. Li (University of Texas Medical Branch, Galveston, USA) (53), respectively."
sparser
"cDNAs encoding Myc-tagged forms of USP4, USP11, Ataxin-3 and A20 were gifts from Dr P.J. Lehner (University of Cambridge, UK) (51), Dr J. Yang (Baylor College of Medicine, Houston, USA) (52), Dr E.A. Fon (Montreal Neurological Institute, Canada) (23) and Dr K. Li (University of Texas Medical Branch, Galveston, USA) (53), respectively."
USP affects USP11
|
2
sparser
"cDNAs encoding Myc-tagged forms of USP4, USP11, Ataxin-3 and A20 were gifts from Dr P.J. Lehner (University of Cambridge, UK) (51), Dr J. Yang (Baylor College of Medicine, Houston, USA) (52), Dr E.A. Fon (Montreal Neurological Institute, Canada) (23) and Dr K. Li (University of Texas Medical Branch, Galveston, USA) (53), respectively."
reach
"In conclusion, the current study emphasized the importance of the interaction of USP11 and Sirt3 in the pathological process of IVDD via regulating oxidative stress-induced ferroptosis, and USP11-mediated oxidative stress-induced ferroptosis is identified as a promising target for treating IVDD."
sparser
"In conclusion, the current study emphasized the importance of the interaction of USP11 and Sirt3 in the pathological process of IVDD via regulating oxidative stress-induced ferroptosis, and USP11-mediated oxidative stress-induced ferroptosis is identified as a promising target for treating IVDD."
RNAi affects USP11
|
2
PA affects USP11
|
2
reach
"Since USP11 has been previously reported as an oncogene in HCC, but its underlying molecular mechanisms in hepatic disease are not entirely understood, we decided to further explore its activity as KLF4‐binding partner.We started by assessing the interaction between KLF4 and USP11 through co‐immunoprecipitation (co‐IP) analysis in transfected HEK293 cells."
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
sparser
"To analyse whether USP11 and NONO interacts with each other directly, purified recombinant USP11 protein was generated and GST‐pulldown assays results showed that recombinant GST‐USP11, but not the GST control, could bind to Myc‐NONO protein expressed in HEK293 cells (Figure xref )."
EGFR-vIII activation affects USP11
|
2
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"cDNAs encoding Myc-tagged forms of USP4, USP11, Ataxin-3 and A20 were gifts from Dr P.J. Lehner (University of Cambridge, UK) (51), Dr J. Yang (Baylor College of Medicine, Houston, USA) (52), Dr E.A. Fon (Montreal Neurological Institute, Canada) (23) and Dr K. Li (University of Texas Medical Branch, Galveston, USA) (53), respectively."
Wobble mutations affects USP11
|
1
Progesterone affects USP11
1
|
Polycomb-group protein affects USP7
|
1
Methylmercury chloride affects USP11
1
|
Methyl methanesulfonate affects USP11
1
|
Methoxyacetic acid affects USP11
1
|
Hsa-miR-10a-5p affects USP11
1
|
Gamma-secretase inhibitor affects USP11
|
1
Enzyme inhibitor affects USP11
1
|
Cycloheximide affects USP11
|
1
Cycloheximide activates USP11. 1 / 1
|
1
Cobalt dichloride affects USP11
1
|
Carbon nanotube affects USP11
1
|
sparser
"An NGPD approach was applied to the identification of USP11 ligands as schematically depicted in xref B . A randomized linear peptide library fused to the gpVIII protein was used to isolate peptides that interact with the USP11 N-terminal DU domains (DUSP and UBL domains in tandem; USP11_DU; xref A )."
Bisphenol A affects USP11
1
|
Benzo[e]pyrene affects USP11
1
|
Aflatoxin B1 affects USP11
1
|
WP1130 affects USP11
|
1
eidos
"For example , 8-mercapto-N - ( ( tetrahydro-3-furanyl ) methyl ) -4 - quinoline carboxamide , LND-57444 , VLX1570 , ML323 , ( ADC-01 , ADC-03 , HBX41108 , HBX19818 , P5091 , P22077 ) , 9 - ( ethoxyimino ) -9 H-indeno ( 1,2 - b ) pyrazine-2 ,3 - dicarbonitrile , WP1130 , Mitoxantrone and GSK2643943A are able to inhibit PSMD14 , UCHL1 , UCHL5 and USP14 , USP1 , USP7 , USP8 , USP9X , USP11 and USP20 , respectively ."
Vehicle Emissions affects USP11
1
|
USP7 affects polycomb-group protein
|
1
USP11 affects vRNA cRNA synthesis
|
1
USP11 affects ubiquitination degradation IkappaBalpha
|
1
USP11 affects ubiquitination degradation Ikappa Balpha
|
1
USP11 affects tumor resistance treatment
|
1
USP11 affects stabilization
|
1
USP11 affects serum TGF-beta1
|
1
USP11 affects sensitizes cells
|
1
USP11 affects sensitized cells
|
1
USP11 affects sensitize gastric cancer chemotherapy
|
1
USP11 affects response NF-kappaB pathway TNFalpha
|
1
USP11 affects resistance poly ADP-ribose polymerase PARP1 Ubiquitination tumor metabolism regulation Ubiquitination mTORC1 signaling pathway
|
1
USP11 inhibits resistance poly ADP-ribose polymerase PARP1 Ubiquitination tumor metabolism regulation Ubiquitination mTORC1 signaling pathway. 1 / 1
|
1
eidos
"USP11 is often overexpressed in cancer and induces resistance to poly ( ADP-ribose ) polymerase 1 ( PARP1 ) inhibitors.124 Ubiquitination in tumor metabolism regulation Ubiquitination in the mTORC1 signaling pathway As an important nutrient and key environmental stimulus , amino acids play a critical role in the mechanistic target of rapamycin complex 1 ( mTORC1 ) signaling pathway ."
USP11 affects resistance 5-fluorouracil
|
1
USP11 affects repair DNA-protein cross-links
|
1
USP11 affects removal polyubiquitin chains bound
|
1
USP11 affects regulation tumour locus p16INK4A
|
1
USP11 affects polycomb-group protein
|
1
USP11 affects poly-ubiquitination
|
1
USP11 affects p21 instability
|
1
eidos
"A 2018 study demonstrated that the loss of USP11 may cause p21 instability and induce G1 / S transition in cells ; in addition , the accumulation of p21 due to DNA damage was completely eliminated in cells lacking USP11 , which led to the abolition of the G2 checkpoint and the induction of apoptosis ( 41 ) ."
USP11 affects nuclear factor 90
|
1
USP11 affects microglial cell activation
|
1
USP11 activates microglial cell activation. 1 / 1
|
1
USP11 affects layer neuron
|
1
USP11 affects immune response
|
1
USP11 activates immune response. 1 / 1
|
1
USP11 affects homologous recombination
|
1
USP11 inhibits homologous recombination. 1 / 1
|
1
USP11 affects hepatic tumorigenesis
|
1
USP11 affects growth survival likely
|
1
USP11 affects epithelial-to-mesenchymal transition cell metastasis ovarian cancer breast cancer
|
1
USP11 affects chemotherapeutic drug efficacy
|
1
USP11 affects cellular senescence
|
1
USP11 inhibits cellular senescence. 1 / 1
|
1
USP11 affects cells being more 5-Fu
|
1
sparser
"An NGPD approach was applied to the identification of USP11 ligands as schematically depicted in xref B . A randomized linear peptide library fused to the gpVIII protein was used to isolate peptides that interact with the USP11 N-terminal DU domains (DUSP and UBL domains in tandem; USP11_DU; xref A )."
USP11 affects biosynthetic process
|
1
USP11 inhibits biosynthetic process. 1 / 1
|
1
USP11 affects autophagy marker P62
|
1
USP11 affects anti-cancer function miR-132-3p
|
1
USP11 affects activation downstream senescent-related signaling pathway
|
1
USP11 affects accumulation unrepaired DPCs cellular hypersensitivity
|
1
USP11 affects USP7, and polycomb-group protein
|
1
USP11 affects USP15 functions later point NF-kappaB activation50
|
1
USP11 affects USP domain
|
1
USP11 affects SMA
|
1
USP11 affects SM therapeutic resistance
|
1
reach
"We demonstrate the utility of this approach by generating low nanomolar fibronectin type III (FN3) monobodies to five human proteins : ubiquitin conjugating enzyme E2 R1 (CDC34), COP9 signalosome complex subunit 5 (COPS5), mitogen activated protein kinase kinase 5 (MAP2K5), Splicing factor 3A subunit 1 (SF3A1) and ubiquitin carboxyl-terminal hydrolase 11 (USP11)."
reach
"As reflected by western blot and qRT-PCR assays, USP11 knockdown led to upregulated expression of KLF2, as well as downregulated levels of NF-κB (p65), its phosphorylation (p-p65), and downstream markers of the NF-κB pathway (cyclinD1, c-myc) in the brain tissues of rats with ICH-like symptoms; these effects of USP11 knockdown alone could be reversed by its combination with either p53 overexpression or KLF2 knockdown (Figure 5A)."
USP11 affects R1
|
1
USP11 affects Phosphatase
|
1
USP11 activates Phosphatase. 1 / 1
|
1
USP11 affects PAM
|
1
USP11 affects Non-structural protein 8b
|
1
USP11 inhibits Non-structural protein 8b. 1 / 1
|
1
USP11 affects NF-kappaB transcription factor RelB
|
1
USP11 affects Mono-ubiquitination LPA1
|
1
USP11 affects MAPK cascade
|
1
USP11 bound to PPP1CA activates MAPK cascade. 1 / 1
|
1
reach
"We demonstrate the utility of this approach by generating low nanomolar fibronectin type III (FN3) monobodies to five human proteins : ubiquitin conjugating enzyme E2 R1 (CDC34), COP9 signalosome complex subunit 5 (COPS5), mitogen activated protein kinase kinase 5 (MAP2K5), Splicing factor 3A subunit 1 (SF3A1) and ubiquitin carboxyl-terminal hydrolase 11 (USP11)."
USP11 affects LC3B-II
|
1
USP11 affects Infections
|
1
USP11 inhibits Infections. 1 / 1
|
1
USP11 affects INK4a
|
1
USP11 affects ICH-like symptoms
|
1
USP11 affects Hemagglutinins
|
1
USP11 affects HPV-16E7
|
1
USP11 affects HIV1gp5
1
|
USP11 affects HBEpCs
|
1
USP11 affects H9C2
|
1
USP11 affects H4R3me2a
|
1
USP11 affects H3K27AC
|
1
USP11 affects G1
|
1
USP11 affects G1 S transition cells
|
1
eidos
"A 2018 study demonstrated that the loss of USP11 may cause p21 instability and induce G1 / S transition in cells ; in addition , the accumulation of p21 due to DNA damage was completely eliminated in cells lacking USP11 , which led to the abolition of the G2 checkpoint and the induction of apoptosis ( 41 ) ."
USP11 affects DSB repair proteins
|
1
USP11 affects DNA Breaks, Double-Stranded
|
1
USP11 activates DNA Breaks, Double-Stranded. 1 / 1
|
1
reach
"Here, we identify the deubiquitylating enzyme USP11 as a previously uncharacterised PRMT1 substrate, and demonstrate that the methylation of USP11 promotes DNA end-resection and the repair of DNA double strand breaks (DSB) by homologous recombination (HR), an event that is independent from another USP11-HR activity, the deubiquitylation of PALB2."
USP11 affects CRL3KEAP1 dependent ubiquitylation PALB2
|
1
USP11 affects Akt mTOR pathway stabilizing
|
1
USP11 affects 5-Fu resistance
|
1
USP11 affects 293T
|
1
USP affects SPRTN
|
1
USP affects PML
|
1
USP domain affects USP11
|
1
TGFbeta receptor affects USP11
|
1
TGFBR1 affects Hemagglutinins
|
1
SOX11 affects 293T
|
1
RSL3 affects USP11
|
1
R1 affects USP11
|
1
PML-IV affects USP11
|
1
PAM affects USP11
|
1
PALB2 affects G1
|
1
NF90 affects USP11
|
1
NF-kappaB transcription factor RelB affects USP11
|
1
MiR-132-3p affects USP11
|
1
Infections affects USP11
|
1
Infections increases the amount of USP11. 1 / 1
|
1
Hemagglutinins affects USP11
|
1
HIV1gp5 affects USP11
1
|
H3K27AC affects USP11
|
1
G1 affects USP11
|
1
FK228 treatment affects USP11
|
1
Ala-Gly-Ser affects USP11
|
1
Ala-Gly-Ser increases the amount of USP11. 1 / 1
|
1
5-fluorouracil affects USP11
|
1
5-fluorouracil activates USP11. 1 / 1
|
1
5-Fu treatment affects USP11
|
1
4-hydroxyphenyl retinamide affects USP11
1
|
293T affects USP11
|
1
1
|