IndraLab
Statements
reach
"As USP7 and USP11 form a complex in T-ALL, future studies are warranted to dissect further the detailed contribution of USP7 and USP11 to NOTCH1 posttranslational regulation and stabilization.We then sought to determine whether USP11 could deubiquitinate NOTCH1 via ubiquitination assays."
sparser
"To assess whether USP7 and USP11 associate with bona fide PRC1 complexes, nuclear extracts from FDFs ( xref ) and 293T cells (not shown) were subjected to size exclusion chromatography on a Superose 6 10/300 column, and individual fractions were analysed by SDS–PAGE and immunoblotting."
USP11 affects cell population proliferation
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USP11 activates cell population proliferation.
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USP11 inhibits cell population proliferation.
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USP11 inhibits cell population proliferation. 10 / 15
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"Notably, other than a finding that loss of one allele of Usp11 in male mice destabilizes PTEN to promote mouse embryonic fibroblast (MEF) and prostate epithelial cell proliferation and tumorigenesis (31), all the findings on the role of USP11 in tumorigenesis and cell differentiation were achieved from cell culture-based systems."
sparser
"Co-immunoprecipitation (Co-IP) of Myc-USP11 with SFB-SPRTN full-length (FL) or ΔSprT, ΔSH, ΔPIP, ΔUBZ, E112A catalytic inactive, and Y117C (SPRTN mutation identified in RJALS patients) mutant constructs showed that SPRTN-USP11 interaction was lost with deletion of the N-terminal SprT domain of SPRTN ( xref A )."
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"Here, we find that USP11 up-regulates AR and c-Myc levels through two mechanisms, including deubiquitination of AR and c-Myc proteins to increase their stability, and deubiquitination of H2A-Ub on AR and c-Myc promoters to enhance their transcription.Our findings differ from a reported function of USP11 as a tumor suppressor in PCa (21), a conclusion based on findings that USP11 knockout up-regulates PTEN and inhibits oncogene-induced fibroblast transformation or tumorigenesis in a TRAMP prostate tumor model."
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"Reexpression of wild-type USP11 in USP11-KD cells (designated USP11 cells) fully restored AR and c-Myc levels, whereas reexpression of the corresponding catalytic-inactive mutant of USP11 in USP11-KD cells (designated USP11 cells) only slightly increased AR and c-Myc protein levels (SI Appendix, Fig. S5K)."
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"Notably, USP11 plays a key role in DNA damage repair depending on its catalytic activity, for example, Xia Ting et al. [20] found that USP11 acts as a histone deubiquitinase in chromatin reorganization during DNA repair, Palak Shah et al. [21] found that USP11 regulates UV-induced DNA damage repair by deubiquitinating XPC, and Tanggang Deng et al. [32] identified that the deubiquitylation and stabilization of p21 by USP11 is essential for cell cycle progression and DNA damage responses."
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"Interestingly, depletion of another BRCA1-interacting protein, BRCA2, results in defects of DNA repair but not that of differentiation in mammary cells (14), which suggests that not all intrinsic DNA repair defects induced by deficiency of BRCA1-interacting proteins promote or are associated with aberrant differentiation.In this study, we discovered that loss of USP11 reduced the expression of E-cadherin and induced DNA damage in MECs and that overexpression of USP11 promoted luminal differentiation, enhanced DNA damage repair, and suppressed tumorigenesis."
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"Notably, Usp11 MECs expressed comparable Cdh1 mRNA levels relative to Usp11 MECs (Fig. S2B), suggesting that the reduction of E-cadherin protein level by Usp11 loss in MECs is unlikely regulated at the transcriptional level.We then performed whole-mount analysis for mouse mammary glands at different ages."
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"Our findings provide compelling genetic and biochemical evidence that USP11 not only promotes DNA damage repair but also deubiquitinates E-cadherin and maintains the luminal features of mammary tumor cells, leading to the suppression of breast cancer.The function of USP11 in controlling tumor development and progression is very puzzling."
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"Interestingly, depletion of another BRCA1-interacting protein, BRCA2, results in defects of DNA repair but not that of differentiation in mammary cells (14), which suggests that not all intrinsic DNA repair defects induced by deficiency of BRCA1-interacting proteins promote or are associated with aberrant differentiation.In this study, we discovered that loss of USP11 reduced the expression of E-cadherin and induced DNA damage in MECs and that overexpression of USP11 promoted luminal differentiation, enhanced DNA damage repair, and suppressed tumorigenesis."
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"Additionally, we observed that depletion of USP11 enhanced the level of the ubiquitinated form of E-cadherin in human T47D cells (Fig. 4E) or mouse luminal cancerous cells (Fig. S4B) compared to the control.Hartsock and Nelson have discovered that K754 and K833 in the JuxtaMembrane Domain (JMD) of mouse E-cadherin are required for ubiquitination and proteasomal degradation of JMD (44)."
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"We found that overexpression of Flag-USP11 drastically reduced the level of the ubiquitinated form of E-cadherin compared to that of the Flag control; however, overexpression of Flag-USP11-C318 A did not change the level of the ubiquitinated form of E-cadherin relative to that of the Flag control (Figs 4C and S4A)."
reach
"USP11 promotes colorectal cancer growth and metastasis by stabilizing PPP1CA, activating the ERK/MAPK pathway, and insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) signaling (151), and interacting with nuclear factor 90 (NF90) to promote HCC proliferation and metastasis (152)."
reach
"The findings of the present study contribute to the search for novel biomarkers related to the RAS/RAF/MAPK pathway, and may provide useful information regarding the best strategy for mCRC treatment and may improve the prognosis of patients with advanced stage CRC.In summary, the present study demonstrated that USP11 activated the ERK/MAPK signaling pathway by stabilizing PPP1CA during the development of CRC."
USP11 affects Neoplasm Metastasis
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sparser
"Previous studies have demonstrated that there is the possibility that USP11 and NONO may interact with each other. xref In order to ascertain the hypothesis, we transfected Flag‐USP11 and Myc‐NONO into HEK293 cells, collected total proteins and used the antibodies against Flag/Myc and the isotype‐matched control IgGs to perform coimmunoprecipitation (co‐IP)."
eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
reach
"This study demonstrated that the depletion of USP11 markedly decreases the half-life of the mutant SFTPC protein by promoting its protein degradation.The ability of polarized epithelial cells to undergo molecular changes that give them the ability to produce extracellular matrix, including collagen and fibronectin, via the EMT, has been implicated in fibrosis and is associated with increased invasion and migration ability 51."
reach
"Using BLM treatment, we demonstrated that USP11 enhances SFTPC -induced fibrosis and EMT processes by increasing the migration and invasion ability of BEAS-2B cells, suggesting that USP11 enhances the pathogenicity of the SFTPC mutation.Heterozygous expression of the mutant SFTPC allele was reported in several cohorts of IPF and childhood interstitial lung disease patients 35, 53-55."
reach
"Conversely, treating USP11-depleted cells with MG132 recovered SFTPC expression (Figure S6; lane 3), suggesting that SFTPC protein accumulation is regulated by the ubiquitin-proteasomal system.Next, we used TUBEs and IP assays to investigate the effect of USP11 on the ubiquitination status of the SFTPC protein."
sparser
"We observed a slight increase in SPRTN-USP11 interaction following treatment with etoposide (VP16), a TOP2 crosslinking agent ( xref D , xref ), camptothecin (CPT), TOP1 cross-linking agent, formaldehyde (nonspecific cross-linking agent), and hydroxyurea (non-cross-linking agent) ( xref )."
sparser
"Co-immunoprecipitation (Co-IP) of Myc-USP11 with SFB-SPRTN full-length (FL) or ΔSprT, ΔSH, ΔPIP, ΔUBZ, E112A catalytic inactive, and Y117C (SPRTN mutation identified in RJALS patients) mutant constructs showed that SPRTN-USP11 interaction was lost with deletion of the N-terminal SprT domain of SPRTN ( xref A )."
sparser
"Co-immunoprecipitation (Co-IP) of Myc-USP11 with SFB-SPRTN full-length (FL) or ΔSprT, ΔSH, ΔPIP, ΔUBZ, E112A catalytic inactive, and Y117C (SPRTN mutation identified in RJALS patients) mutant constructs showed that SPRTN-USP11 interaction was lost with deletion of the N-terminal SprT domain of SPRTN ( xref A )."
reach
"16
Although USP11 plays a critical role in HCC progression, and our earlier research established that USP11 inhibits autophagy through targeting ERK/mTOR pathway to promote HCC metastasis,
16
the mechanisms of USP11 in HCC glycolysis remain poorly understood.Various biological processes, including hypoxia, are related to protein homeostasis, which maintained by post‐translational modification."
reach
"Therefore, further studies are warranted in this regard.Multiple studies suggest that mTOR may be a central regulator of autophagy.100 101 Moreover, some studies have shown that USP11 can inhibit cell autophagy through the ERK/mTOR pathway, which promotes the proliferation and metastasis of cancer cells."
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"Recent studies have demonstrated that deubiquitinases, such as X-linked ubiquitin-specific peptidase 10 (USP10), USP11, and USP13, increase the aggregation of tau, enhance vulnerability to tauopathy, and delay tau degradation by deubiquitinating tau (Liu et al., 2019; Wei et al., 2022; Yan et al., 2022)."
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"As shown in Fig. 1A,B, the levels of both USP11 and total tau proteins were significantly downregulated after IsoLiPro treatment in HEK293-hTau cells overexpressing tau441.To further confirm the interactions between USP11 and tau and the involvement of USP11 in IsoLiPro-induced tau reduction, HEK293-hTau cells overexpressing USP11 (HEK293-hTau/USP11) was conducted."
reach
"In addition, expression of wild-type XIAP leads to the inhibition of anoikis, we observed that disruption of interaction between XIAP and USP11 by expression of XIAP L207P mutant (interaction deficient) significantly attenuates the inhibition of anoikis by XIAP (Supplemental Fig. 6)."
sparser
"To validate the impact of Cys203 and Leu207 as well as Lys206 on XIAP in mediating the interaction of XIAP with USP11, we performed a multiple sequence alignment at that particular region (residues 200–210), using the aligned the amino acid stretch from 200 to 210 of human XIAP with mouse, rat and xenopus XIAP sequences as well as the human CIAP1 and CIAP2."
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"While we have identified the critical role of UPS11 in mammary tumorigenesis and further dissected the mechanism by which USP11 catalyzes XIAP for deubiquitylation, the mechanism that initiates the accumulation of USP11 in breast cancer tissue and its subsequent regulation during the tumor development still remains unknown."
reach
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin induced inflammatory lung injury."
sparser
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin-induced inflammatory lung injury."
sparser
"LPA1 is associated with USP11 in quiescent cells, while LPA treatment triggers LPA1 dis-association with USP11 and in turn binding to Nedd4L. Knockdown or inhibition of USP11 reduces LPA1 stability, levels of LPA1, and LPA1-CD14 interaction complex; thereby diminishing both LPA- and LPS-induced inflammatory responses and lung injury in preclinical murine models."
reach
"In conclusion, the current study emphasized the importance of the interaction of USP11 and Sirt3 in the pathological process of IVDD via regulating oxidative stress-induced ferroptosis, and USP11-mediated oxidative stress-induced ferroptosis is identified as a promising target for treating IVDD."
reach
"Since USP11 has been previously reported as an oncogene in HCC, but its underlying molecular mechanisms in hepatic disease are not entirely understood, we decided to further explore its activity as KLF4‐binding partner.We started by assessing the interaction between KLF4 and USP11 through co‐immunoprecipitation (co‐IP) analysis in transfected HEK293 cells."
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"25
,
26
,
27
Recently, USP11 was shown to promote HCC development,
28
but the underlying molecular mechanisms involved in this pathogenic process remain poorly understood.In this study, we used a proteomic approach to identify KLF4‐interacting DUBs and firstly discovered that USP11 was responsible for deubiquitinating KLF4 in HCC cells."
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"Next, to determine whether USP11 deubiquitinates AR, we coexpressed Flag-AR, Myc-tagged USP11, and/or HA-ubiquitin in 293T cells, lysed cells under denaturing condition, immunoprecipitated Flag-AR with anti-Flag M2 beads and performed western blotting with HA antibodies to monitor Flag-AR polyubiquitination."
reach
"Reexpression of wild-type USP11 in USP11-KD cells (designated USP11 cells) fully restored AR and c-Myc levels, whereas reexpression of the corresponding catalytic-inactive mutant of USP11 in USP11-KD cells (designated USP11 cells) only slightly increased AR and c-Myc protein levels (SI Appendix, Fig. S5K)."
reach
"We also observed HA-USP11-WT peaks at AR or c-Myc gene promoter regions where we had detected no HA-USP11-CS peaks (Fig. 5 C and D), consistent with our ChIP-PCR data showing that USP11 binds to AR and c-Myc promoters to induce H2A deubiquitination (Fig. 4 A and B and SI Appendix, Fig. S5 L and M)."
sparser
"Notably, wild-type (WT) USP11 deubiquitinated PTEN in vivo and in vitro, whereas the catalytically inactive USP11 C318S (CS) mutant, which could still bind to PTEN, exerted a dramatically diminished ability to deubiquitinate PTEN, and even exhibited a more heavy ubiquitinating effect (Fig. xref and Supplementary Fig. xref )."
reach
"It has been reported that, on the one hand, USP11 promotes cell proliferation and tumorigenesis through stabilizing its substrates cIAP2, NONO, NF90, E2F1, and cytoplasmic p21, but on the other hand, USP11 suppresses tumorigenesis by deubiquitinating its substrates PML, Mgl-1, PTEN, ARID1A, and nuclear p21 (29, 30)."
reach
"In conclusion, the current study emphasized the importance of the interaction of USP11 and Sirt3 in the pathological process of IVDD via regulating oxidative stress-induced ferroptosis, and USP11-mediated oxidative stress-induced ferroptosis is identified as a promising target for treating IVDD."
Mitoxantrone affects USP11
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Mitoxantrone inhibits USP11.
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Mitoxantrone activates USP11.
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"In addition, expression of wild-type XIAP leads to the inhibition of anoikis, we observed that disruption of interaction between XIAP and USP11 by expression of XIAP L207P mutant (interaction deficient) significantly attenuates the inhibition of anoikis by XIAP (Supplemental Fig. 6)."
sparser
"To validate the impact of Cys203 and Leu207 as well as Lys206 on XIAP in mediating the interaction of XIAP with USP11, we performed a multiple sequence alignment at that particular region (residues 200–210), using the aligned the amino acid stretch from 200 to 210 of human XIAP with mouse, rat and xenopus XIAP sequences as well as the human CIAP1 and CIAP2."
sparser
"Previous studies have demonstrated that there is the possibility that USP11 and NONO may interact with each other. xref In order to ascertain the hypothesis, we transfected Flag‐USP11 and Myc‐NONO into HEK293 cells, collected total proteins and used the antibodies against Flag/Myc and the isotype‐matched control IgGs to perform coimmunoprecipitation (co‐IP)."
USP11 affects ferroptosis
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USP11 activates ferroptosis.
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USP11 activates ferroptosis. 10 / 12
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"What accords with previous studies is that overexpression of Sirt3 could ameliorate IVDD induced by USP11 deletion [84], which indicates that the stability of Sirt3 is essential for regulatory effect of USP11 on oxidative stress-induced ferroptosis in IVDD.In conclusion, ferroptosis is associated closely with the process of IVDD."
USP11 inhibits ferroptosis.
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USP11 affects apoptotic process
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USP11 inhibits apoptotic process.
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USP11 inhibits apoptotic process. 10 / 12
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eidos
"* P < 0.05 MiR-132-3p constrains cell growth and metastasis and increases apoptosis by decreasing USP11 in colorectal cancer cells To study the function of miR-132-3p / USP11 axis on colorectal cancer progression , HCT116 and SW480 cells were transfected with miR-NC , miR-132-3p mimic , miR-132-3p mimic + pcDNA , or USP11 overexpression vector ."
USP11 activates apoptotic process.
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"Moreover, Heeyoung Yang et al. [30] found that USP11 regulates liver disease status by removing the K63 ubiquitin chain of KLF4; and Dan Wang et al. [31] identified that USP11 drives Peg10 gene expression and activates lung epithelial cells by removing the K63 ubiquitin chain of phosphorylated E2F1."
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"Moreover, Heeyoung Yang et al. [30] found that USP11 regulates liver disease status by removing the K63 ubiquitin chain of KLF4; and Dan Wang et al. [31] identified that USP11 drives Peg10 gene expression and activates lung epithelial cells by removing the K63 ubiquitin chain of phosphorylated E2F1."
USP11 affects Neoplasm Invasiveness
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USP11 activates Neoplasm Invasiveness.
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USP11 activates Neoplasm Invasiveness. 10 / 12
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USP11 activates Neoplasm Invasiveness. 2 / 2
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USP11 inhibits Neoplasm Invasiveness.
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"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
USP11 is modified
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USP11 is phosphorylated.
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sparser
"Additionally, ERK1/2 can inhibit the phosphorylation of USP11 and thus downregulate the level of cytoplasmic p21, which can play an oncogenic and pro-cancer role in BC. xref However, whether USP11 can inhibit autophagy through the ERK/mTOR pathway and play a key role in BC development needs further exploration."
sparser
"Intriguingly, the activity of USP11 could be phosphorylated by FASN-induced PI3K-S6 kinase signaling, and phosphorylated USP11 further enhances its interaction with eIF4B and thereby promoting oncogenic translation [ xref ], implying that the activity of deubiquitinase USP11 is also activated by the kinase and enriches the complex regulatory network of USP11."
sparser
"Bandish Kapadia et al. [ xref ] found that phosphorylation of USP11 stabilizes and deubiquitinates transcription factor EIF4B and further promotes the progression and malignancy of diffuse large B-cell lymphoma, USP11 is phosphorylated by FASN-induced S6 kinase, which also suggests that the status of lymphoma is affected by altered lipid metabolism (Fig. xref )."
USP11 is ubiquitinated.
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USP11 is acetylated.
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USP11 decreases the amount of USP11.
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"Similarly, USP11 KD decreased levels of the c-Myc target genes MCM3, CDC6, CCNE2, MKI67, and CDK4 in Rv1 (SI Appendix, Fig. S2L), VCaP (SI Appendix, Fig. S2M), C4-2 (SI Appendix, Fig. S2N), and DU145 (SI Appendix, Fig. S2O) cells.To evaluate the potential relevance of these in vitro findings to PCa tissues, we analyzed and correlated USP11 transcript levels with those of AR or c-Myc in human PCa datasets."
USP11 deubiquitinates USP11.
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"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
USP11 activates USP11.
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USP11 inhibits USP11.
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"This provides us a new perspective for future studies.In conclusion, in our present study, we found that IsoLiPro can lower USP11 protein levels both in vivo and in vitro, mainly through modulating protein degradation without impacting directly the USP11 enzyme activity, and consequently ameliorate AD pathologies in transgenic AD animal model."
USP11 increases the amount of USP11.
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"Taken together, we identified a feedback loop regulation between USP11 and NOTCH1, in which NOTCH1 transcriptionally activates USP11 expression and, in turn, USP11 controls NOTCH1 protein levels via deubiquitination.Here, we identified a regulatory feedback loop between NOTCH1 and the USP11 deubiquitinase in T-cell acute lymphoblastic leukemia (T-ALL)."
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"However, the specific roles and mechanisms by which the ubiquitin-proteasome system contributes to gender differences in the pathogenesis of ACTH PitNETs remain unexamined.In this study, we found that USP11 promotes the deubiquitination of TPIT, enhancing POMC transcription and ACTH secretion, thereby increasing susceptibility to Cushing’s disease in women."
USP11 affects Carcinogenesis
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USP11 activates Carcinogenesis.
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USP11 activates Carcinogenesis. 8 / 8
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"It is not surprising that USP11, a deubiquitinase widely expressed in multiple tissues or cell lineages, has many substrates including oncogenic proteins; however, it remains to be investigated whether, under physiological conditions, USP11 promotes tumorigenesis through deubiquitinating those substrates in vivo."
reach
"Additionally, there is an urgent need to develop effective inhibitors targeting the USP11-SREBF1 axis and evaluate their impact on HCC proliferation and metastasis in preclinical and clinical studies.In conclusion, our study highlights that USP11 enhances lipogenesis and tumorigenesis in HCC by regulating SREBF1 stability."
USP11 inhibits Carcinogenesis.
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USP11 inhibits Carcinogenesis. 6 / 6
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"Interestingly, depletion of another BRCA1-interacting protein, BRCA2, results in defects of DNA repair but not that of differentiation in mammary cells (14), which suggests that not all intrinsic DNA repair defects induced by deficiency of BRCA1-interacting proteins promote or are associated with aberrant differentiation.In this study, we discovered that loss of USP11 reduced the expression of E-cadherin and induced DNA damage in MECs and that overexpression of USP11 promoted luminal differentiation, enhanced DNA damage repair, and suppressed tumorigenesis."
reach
"Notably, other than a finding that loss of one allele of Usp11 in male mice destabilizes PTEN to promote mouse embryonic fibroblast (MEF) and prostate epithelial cell proliferation and tumorigenesis (31), all the findings on the role of USP11 in tumorigenesis and cell differentiation were achieved from cell culture-based systems."
reach
"Although most results on the tumor suppressive role of USP11 were also derived from in vitro cell culture systems, a finding that the loss of one allele of Usp11 in male mice destabilizes PTEN to promote prostate epithelial cell tumorigenesis provides genetic evidence that USP11 suppresses prostate tumorigenesis in males (29)."
reach
"These mechanisms might be of therapeutic importance in cancer, because defective HR renders cells susceptible to inhibition of base excision repair (BER) mediated by poly (ADP-ribose) polymerase 1 (PARP1) XREF_BIBR - XREF_BIBR : the deubiquitylating enzyme (DUB) ubiquitin carboxyl-terminal hydrolase 11 (USP11) deubiquitylates partner and localizer of BRCA2 (PALB2) during S and G2 phases following DNA damage, allowing the formation of the BRCA1, PALB2, and BRCA2 complex and HR repair to advance in these phases of the cell cycle 64."
USP11 affects Nucleoproteins
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USP11 binds Nucleoproteins.
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USP11 ubiquitinates Nucleoproteins.
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USP11 deubiquitinates Nucleoproteins.
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"We observed a slight increase in SPRTN-USP11 interaction following treatment with etoposide (VP16), a TOP2 crosslinking agent ( xref D , xref ), camptothecin (CPT), TOP1 cross-linking agent, formaldehyde (nonspecific cross-linking agent), and hydroxyurea (non-cross-linking agent) ( xref )."
sparser
"Co-immunoprecipitation (Co-IP) of Myc-USP11 with SFB-SPRTN full-length (FL) or ΔSprT, ΔSH, ΔPIP, ΔUBZ, E112A catalytic inactive, and Y117C (SPRTN mutation identified in RJALS patients) mutant constructs showed that SPRTN-USP11 interaction was lost with deletion of the N-terminal SprT domain of SPRTN ( xref A )."
USP11 affects lipid biosynthetic process
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"In neuroblastoma, USP11- and TCEAL1-dependent genes define a gene expression program that is characteristic for mesenchymal tumors, which are described as able to escape from many treatments, suggesting that the USP11/TCEAL1 complex promotes transcription elongation to support a critical oncogenic gene expression program."
reach
"The findings of the present study contribute to the search for novel biomarkers related to the RAS/RAF/MAPK pathway, and may provide useful information regarding the best strategy for mCRC treatment and may improve the prognosis of patients with advanced stage CRC.In summary, the present study demonstrated that USP11 activated the ERK/MAPK signaling pathway by stabilizing PPP1CA during the development of CRC."
reach
"USP11 promotes colorectal cancer growth and metastasis by stabilizing PPP1CA, activating the ERK/MAPK pathway, and insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) signaling (151), and interacting with nuclear factor 90 (NF90) to promote HCC proliferation and metastasis (152)."
reach
"In neuroblastoma, USP11- and TCEAL1-dependent genes define a gene expression program that is characteristic for mesenchymal tumors, which are described as able to escape from many treatments, suggesting that the USP11/TCEAL1 complex promotes transcription elongation to support a critical oncogenic gene expression program."
sparser
"Notably, wild-type (WT) USP11 deubiquitinated PTEN in vivo and in vitro, whereas the catalytically inactive USP11 C318S (CS) mutant, which could still bind to PTEN, exerted a dramatically diminished ability to deubiquitinate PTEN, and even exhibited a more heavy ubiquitinating effect (Fig. xref and Supplementary Fig. xref )."
reach
"Additionally, there is an urgent need to develop effective inhibitors targeting the USP11-SREBF1 axis and evaluate their impact on HCC proliferation and metastasis in preclinical and clinical studies.In conclusion, our study highlights that USP11 enhances lipogenesis and tumorigenesis in HCC by regulating SREBF1 stability."
EIF affects USP11
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"One novel potential lymphoma-associated driver of eIF4B is fatty acid synthase (FASN) which stabilizes eIF4B and increase expression of oncoproteins such as MYC, BCL6 and MCL1 (a BCL2-related anti-apoptotic protein) via formation of a complex between eIF4B and the deubiquitinase USP11 in DLBCL cells [ xref ]."
USP11 affects eIF
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"One novel potential lymphoma-associated driver of eIF4B is fatty acid synthase (FASN) which stabilizes eIF4B and increase expression of oncoproteins such as MYC, BCL6 and MCL1 (a BCL2-related anti-apoptotic protein) via formation of a complex between eIF4B and the deubiquitinase USP11 in DLBCL cells [ xref ]."
IsoLiPro affects USP11
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IsoLiPro decreases the amount of USP11.
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reach
"This provides us a new perspective for future studies.In conclusion, in our present study, we found that IsoLiPro can lower USP11 protein levels both in vivo and in vitro, mainly through modulating protein degradation without impacting directly the USP11 enzyme activity, and consequently ameliorate AD pathologies in transgenic AD animal model."
IsoLiPro binds USP11.
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IsoLiPro inhibits USP11.
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MiR-132-3p affects USP11
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USP11 affects translation
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USP11 affects cell growth
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USP11 inhibits cell growth.
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USP11 activates cell growth.
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"USP11 binds to the epidermal growth factor receptor (EGFR) and deubiquitinates and protects the EGFR from proteasome-dependent degradation, enhancing the transduction of the downstream signaling pathway of TGF-β 67.The ubiquitin system can modulate key molecules of the MAPK signaling pathway and thereby regulate the fibrosis process."
sparser
"For example, Prmt1 methylation of Rbm15 R578 (RNA binding motif protein 15) leads to its degradation via ubiquitylation by Cnot4 (CCR4-NOT transcription complex subunit 4) E3 ligase [ xref ], while Usp11 (Ubiquitin specific peptidase 11) is methylated by Prmt1 at R433, promoting DNA damage repair [ xref ]."
reach
"For example, Prmt1 methylation of Rbm15 (RNA binding motif protein 15) leads to its degradation via ubiquitylation by Cnot4 (CCR4-NOT transcription complex subunit 4) E3 ligase [32], while Usp11 (Ubiquitin specific peptidase 11) is methylated by Prmt1 at R433, promoting DNA damage repair [33]."
reach
"Taken together, we identified a feedback loop regulation between USP11 and NOTCH1, in which NOTCH1 transcriptionally activates USP11 expression and, in turn, USP11 controls NOTCH1 protein levels via deubiquitination.Here, we identified a regulatory feedback loop between NOTCH1 and the USP11 deubiquitinase in T-cell acute lymphoblastic leukemia (T-ALL)."
reach
"Taken together, we demonstrate transcriptional activation of USP11 by NOTCH1 in T-ALL.We then hypothesized that USP11 might control NOTCH1 protein levels through deubiquitination based on the positive correlation between USP11 and NOTCH1 protein expression and the deubiquitinating activity of USP11."
reach
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin induced inflammatory lung injury."
sparser
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin-induced inflammatory lung injury."
sparser
"LPA1 is associated with USP11 in quiescent cells, while LPA treatment triggers LPA1 dis-association with USP11 and in turn binding to Nedd4L. Knockdown or inhibition of USP11 reduces LPA1 stability, levels of LPA1, and LPA1-CD14 interaction complex; thereby diminishing both LPA- and LPS-induced inflammatory responses and lung injury in preclinical murine models."
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"In summary, our study identifies the functions of Usp11 mediated Sox11 stabilization in cortical development, provides an explanation for the association of Usp11 mutation with neurological disorder, and highlights the importance of deubiquitination triggered protein stabilization in the developmental process."
USP11 affects 5-formyluracil
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"In line with this notion, we showed that mouse Usp11 was repressed by the Notch and Hes1 axis, as overexpression of an active form of Notch (Notch intracellular domain, referred to as NIC) or Hes1 in a neuroblastoma cell line N2a diminished Usp11 expression and the promoter activity of Usp11 gene."
reach
"In line with this notion, we showed that mouse Usp11 was repressed by the Notch and Hes1 axis, as overexpression of an active form of Notch (Notch intracellular domain, referred to as NIC) or Hes1 in a neuroblastoma cell line N2a diminished Usp11 expression and the promoter activity of Usp11 gene."
reach
"Since USP11 has been previously reported as an oncogene in HCC, but its underlying molecular mechanisms in hepatic disease are not entirely understood, we decided to further explore its activity as KLF4‐binding partner.We started by assessing the interaction between KLF4 and USP11 through co‐immunoprecipitation (co‐IP) analysis in transfected HEK293 cells."
reach
"However, no research has reported the mechanism underlying GREM1 ubiquitination and the interaction between USP11 and GREM1 so far.Demethyleneberberine (DMB), a natural product, is a component from the rutaceous plant Cortex Phellodendri Chinensis (CPC) with anti-inflammatory, neuroprotective, antioxidant and antimicrobial properties [30,31,32,33]."
reach
"Notably, USP11 plays a key role in DNA damage repair depending on its catalytic activity, for example, Xia Ting et al. [20] found that USP11 acts as a histone deubiquitinase in chromatin reorganization during DNA repair, Palak Shah et al. [21] found that USP11 regulates UV-induced DNA damage repair by deubiquitinating XPC, and Tanggang Deng et al. [32] identified that the deubiquitylation and stabilization of p21 by USP11 is essential for cell cycle progression and DNA damage responses."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
reach
"Interestingly, previous studies further indicated that USP11 inhibition may protect amyloid aggregation-induced paralysis in C elegans and increase BACE1 degradation in AD model mice (Basic et al, 2021; Wu et al, 2022), which may also contribute to the ameliorated amyloid deposition induced by IsoLiPro.Neuroinflammation plays a pivotal role in the pathology of AD and influences the disease’s progression."
USP11 affects MGL
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6
reach
"However, no research has reported the mechanism underlying GREM1 ubiquitination and the interaction between USP11 and GREM1 so far.Demethyleneberberine (DMB), a natural product, is a component from the rutaceous plant Cortex Phellodendri Chinensis (CPC) with anti-inflammatory, neuroprotective, antioxidant and antimicrobial properties [30,31,32,33]."
USP11 affects DNA-templated transcription
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6
USP11 activates DNA-templated transcription.
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4
USP11 bound to TCEAL1 activates DNA-templated transcription. 2 / 2
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2
reach
"In neuroblastoma, USP11- and TCEAL1-dependent genes define a gene expression program that is characteristic for mesenchymal tumors, which are described as able to escape from many treatments, suggesting that the USP11/TCEAL1 complex promotes transcription elongation to support a critical oncogenic gene expression program."
USP11 activates DNA-templated transcription. 2 / 2
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2
USP11 inhibits DNA-templated transcription.
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2
USP11 inhibits DNA-templated transcription. 2 / 2
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2
reach
"Lisa Dwane et al. [36] identified USP11 as a novel transcriptional regulator of ERα in breast cancer through a functional genomic screen, and they found that USP11 could significantly inhibit the activity of ERα and the transcription of downstream target genes in response to estradiol stimulation."
USP11 affects Carcinoma, Hepatocellular
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6
RSL3 affects USP11
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6
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
Nucleoproteins affects USP11
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1
5
MGL affects USP11
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6
Lsh affects USP11
|
5
reach
"However, USP11 FL features a ' burst ' phase (XREF_SUPPLEMENTARY), indicating that, in contrast to USP4 FL and USP15 FL, slow ubiquitin off-rates limit USP11 activity but the DUSP-Ubl domain is not able to promote ubiquitin release or is not efficient in doing so, in agreement with a recent publication XREF_BIBR."
USP11 affects viral RNA replication
|
5
eidos
"When cellular USP11 was knocked down , the amounts of vRNA and cRNA of the wild-type virus increased by about 2.5-fold ( Figure 7A , lane 1 versus lanes 2 and 3 ) , indicating that USP11 inhibits viral RNA replication as previously mentioned ; with the mutant virus defective in NP ubiquitination ( K184R ) , however , there was no significant difference in viral RNA synthesis between USP11 knockdown and control cells ( Figure 7A , lanes 4-6 ) ."
USP11 affects lsh
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5
USP11 affects cell differentiation
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5
USP11 activates cell differentiation. 5 / 5
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5
reach
"Interestingly, depletion of another BRCA1-interacting protein, BRCA2, results in defects of DNA repair but not that of differentiation in mammary cells (14), which suggests that not all intrinsic DNA repair defects induced by deficiency of BRCA1-interacting proteins promote or are associated with aberrant differentiation.In this study, we discovered that loss of USP11 reduced the expression of E-cadherin and induced DNA damage in MECs and that overexpression of USP11 promoted luminal differentiation, enhanced DNA damage repair, and suppressed tumorigenesis."
USP11 affects RNA replication
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5
USP11 inhibits RNA replication. 5 / 5
|
5
reach
"When cellular USP11 was knocked down, the amounts of vRNA and cRNA of the wild-type virus increased by about 2.5-fold ( Figure 7A, lane 1 versus lanes 2 and 3) , indicating that USP11 inhibits viral RNA replication as previously mentioned; with the mutant virus defective in NP ubiquitination (K184R), however, there was no significant difference in viral RNA synthesis between USP11 knockdown and control cells ( Figure 7A, lanes 4-6) ."
reach
"This result further supports the conclusion that USP11 inhibits viral RNA replication through deubiquitinating NP.Ubiquitination is a posttranslational modification, in which ubiquitin chains or single ubiquitin molecules are linked to target proteins, giving rise to poly-or monoubiquitination (Weissman, 2001) ."
USP11 affects PB2
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5
USP11 affects MAPK cascade
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5
USP11 activates MAPK cascade. 3 / 3
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3
reach
"The findings of the present study contribute to the search for novel biomarkers related to the RAS/RAF/MAPK pathway, and may provide useful information regarding the best strategy for mCRC treatment and may improve the prognosis of patients with advanced stage CRC.In summary, the present study demonstrated that USP11 activated the ERK/MAPK signaling pathway by stabilizing PPP1CA during the development of CRC."
USP11 bound to PPP1CA activates MAPK cascade. 2 / 2
|
2
reach
"As reflected by western blot and qRT-PCR assays, USP11 knockdown led to upregulated expression of KLF2, as well as downregulated levels of NF-κB (p65), its phosphorylation (p-p65), and downstream markers of the NF-κB pathway (cyclinD1, c-myc) in the brain tissues of rats with ICH-like symptoms; these effects of USP11 knockdown alone could be reversed by its combination with either p53 overexpression or KLF2 knockdown (Figure 5A)."
PB2 affects USP11
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5
5-formyluracil affects USP11
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5
5-formyluracil inhibits USP11.
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3
5-formyluracil increases the amount of USP11.
|
2
USP11 affects proteolysis
|
4
USP11 activates proteolysis. 4 / 4
|
4
reach
"This provides us a new perspective for future studies.In conclusion, in our present study, we found that IsoLiPro can lower USP11 protein levels both in vivo and in vitro, mainly through modulating protein degradation without impacting directly the USP11 enzyme activity, and consequently ameliorate AD pathologies in transgenic AD animal model."
USP11 affects glycolytic process
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4
USP11 affects cell death
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4
USP11 inhibits cell death.
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2
USP11 activates cell death.
|
2
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
reach
"As shown in Fig. 1A,B, the levels of both USP11 and total tau proteins were significantly downregulated after IsoLiPro treatment in HEK293-hTau cells overexpressing tau441.To further confirm the interactions between USP11 and tau and the involvement of USP11 in IsoLiPro-induced tau reduction, HEK293-hTau cells overexpressing USP11 (HEK293-hTau/USP11) was conducted."
reach
"USP11 binds to the epidermal growth factor receptor (EGFR) and deubiquitinates and protects the EGFR from proteasome-dependent degradation, enhancing the transduction of the downstream signaling pathway of TGF-β 67.The ubiquitin system can modulate key molecules of the MAPK signaling pathway and thereby regulate the fibrosis process."
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
reach
"We also observed HA-USP11-WT peaks at AR or c-Myc gene promoter regions where we had detected no HA-USP11-CS peaks (Fig. 5 C and D), consistent with our ChIP-PCR data showing that USP11 binds to AR and c-Myc promoters to induce H2A deubiquitination (Fig. 4 A and B and SI Appendix, Fig. S5 L and M)."
Lithium(1+) affects USP11
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3
Lithium(1+) decreases the amount of USP11. 3 / 3
|
3
reach
"In our present study, while IsoLiPro inhibits USP11, it has little effect on USP25 protein levels, suggesting a specific inhibition of IsoLiPro on USP11.In our present study, IsoLiPro but not lithium decreases the USP11 protein level, indicating the whole molecule IsoLiPro might be responsible for its impacts on USP11."
USP11 affects melanoma cells
|
3
USP11 affects lipopolysaccharide
|
3
USP11 affects influenza A virus RNA replication
|
3
USP11 affects inflammatory response
|
3
USP11 affects corticotropin secretion
|
3
USP11 affects cell migration
|
3
USP11 activates cell migration. 3 / 3
|
3
reach
"These findings confirmed that USP11 can modulate HIF‐1α activity.In previous work, we reported that USP11 might increase both HCC cell migration and proliferation,
16
and HIF‐1α has been shown to trigger the transcription of genes involved in HCC proliferation, angiogenesis, metastasis and invasion."
USP11 affects cell cycle
|
3
USP11 affects SUMO-ubiquitin chains
|
3
USP11 affects SPRTN auto-proteolysis
|
3
USP11 affects Reperfusion Injury
|
3
USP11 affects IsoLiPro
|
3
USP11 affects IKK_complex
|
3
USP11 affects DNA repair
|
3
USP11 inhibits DNA repair. 3 / 3
|
3
reach
"More interestingly, whilst expression of USP11 rescued the defect in DNA repair induced by USP11 depletion, confirming the specificity of our siRNA sequences, expression of USP11-R433K could not, implying that methylation is required for USP11 to effectively function in the repair of olaparib-induced lesions (Fig. 4a, b)."
USP11 affects Cell Survival
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3
USP11 CS affects USP11
|
3
PB2 affects Nucleoproteins
|
3
FK228 affects USP11
|
3
Topoisomerase inhibitor affects USP11
|
2
Progesterone affects USP11
1
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1
Progesterone increases the amount of USP11. 1 / 2
1
|
1
Knockout HDAC1 HDAC2 affects USP11
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2
Doxycycline affects USP11
|
2
USP11 affects response to xenobiotic stimulus
|
2
USP11 affects resistance 5-Fu
|
2
USP11 affects replication
|
1
1
USP11 affects pyroptosis
|
2
USP11 affects protein deubiquitination
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2
USP11 activates protein deubiquitination. 2 / 2
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2
eidos
"100 A recent study indicated that USP7 stabilizes the Hippo pathway by deubiquitinating the transcriptional coactivator Yorkie , promoting HCC growth.101 Further , USP7 participates in lipogenesis-associated HCC progression by promoting stabilization and transcription of zinc-finger protein 638.102 USP11 is upregulated in HCC and is correlated with shorter survival in HCC patients.103 ,104 USP11 promotes HCC cell survival , invasion , and metastatic potency in vitro and in vivo.103 ,104 Mechanistically , USP11 interacts with nuclear factor 90 ( NF90 ) and promotes its deubiquitination , thereby stabilizing it in HCC cells.103 Consistent with this , USP11 expression positively correlates with NF90 expression in human HCC tissues.103 Similar to USP11 , elevated USP13 in HCC patients is associated with a poor prognosis ."
USP11 affects migration
|
2
USP11 affects miR-132-3p
|
2
USP11 affects melanoma cell
|
2
USP11 affects localization
|
2
USP11 affects lipid metabolic process
|
2
USP11 affects influenza virus replication
|
2
USP11 affects influenza virus RNA replication
|
2
USP11 affects hemopoiesis
|
2
USP11 affects gene expression
|
2
USP11 bound to TCEAL1 activates gene expression. 2 / 2
|
2
reach
"In neuroblastoma, USP11- and TCEAL1-dependent genes define a gene expression program that is characteristic for mesenchymal tumors, which are described as able to escape from many treatments, suggesting that the USP11/TCEAL1 complex promotes transcription elongation to support a critical oncogenic gene expression program."
USP11 affects cholesterol efflux
|
2
USP11 affects cellular senescence
|
2
USP11 affects TGFbeta receptor
|
2
USP11 affects SPRTN deubiquitination
|
2
USP11 affects RSL3
|
2
reach
"Finally, pharmacological inhibition of USP11 prevented PF caused by TGF-beta in hiPSCs-SFTPC I73T -AOs and BLM-induced mouse model, underscoring its therapeutic potential.Conclusions: Altogether, USP11 is a major protein stabilizer of SFTPC, and the clinical inhibition of USP11 during PF could be a novel therapeutic approach for ILD patients."
USP11 affects Lymphoma, B-Cell
|
2
USP11 activates Lymphoma, B-Cell. 2 / 2
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2
reach
"Bandish Kapadia et al. [37] found that phosphorylation of USP11 stabilizes and deubiquitinates transcription factor EIF4B and further promotes the progression and malignancy of diffuse large B-cell lymphoma, USP11 is phosphorylated by FASN-induced S6 kinase, which also suggests that the status of lymphoma is affected by altered lipid metabolism (Fig. 4)."
sparser
"Finally, we use mutational analysis to demonstrate that distinct regions of SAP25 participate in its interaction with USP11, OGT/TETs, and SCF(FBXO3).) These results suggest that SAP25 may function as an adaptor protein to coordinate the assembly of different enzymatic complexes to control Sin3/HDAC-mediated gene expression."
USP11 affects IVDD
|
2
USP11 affects H2BK120
|
2
USP11 affects H2AK119
|
2
sparser
"China recently did a lot of work in the discovery of multiple drug resistance mechanisms, including overexpression of the USP11-BIP axis leading to drug resistance ( xref ), significantly upregulated TTK expression in high-grade serous ovarian carcinoma (HGSOC), and cisplatin-resistant ovarian cancer cells ( xref )."
USP11 affects DNA Damage
|
2
USP11 activates DNA Damage. 2 / 2
|
2
reach
"Interestingly, depletion of another BRCA1-interacting protein, BRCA2, results in defects of DNA repair but not that of differentiation in mammary cells (14), which suggests that not all intrinsic DNA repair defects induced by deficiency of BRCA1-interacting proteins promote or are associated with aberrant differentiation.In this study, we discovered that loss of USP11 reduced the expression of E-cadherin and induced DNA damage in MECs and that overexpression of USP11 promoted luminal differentiation, enhanced DNA damage repair, and suppressed tumorigenesis."
USP11 affects Colorectal Neoplasms
|
2
USP11 activates Colorectal Neoplasms. 2 / 2
|
2
USP11 affects Carcinoma, Squamous Cell
|
2
USP11 affects CS
|
2
RNAi affects USP11
|
2
sparser
"Finally, we use mutational analysis to demonstrate that distinct regions of SAP25 participate in its interaction with USP11, OGT/TETs, and SCF(FBXO3).) These results suggest that SAP25 may function as an adaptor protein to coordinate the assembly of different enzymatic complexes to control Sin3/HDAC-mediated gene expression."
sparser
"China recently did a lot of work in the discovery of multiple drug resistance mechanisms, including overexpression of the USP11-BIP axis leading to drug resistance ( xref ), significantly upregulated TTK expression in high-grade serous ovarian carcinoma (HGSOC), and cisplatin-resistant ovarian cancer cells ( xref )."
reach
"Intriguingly, the activity of USP11 could be phosphorylated by FASN-induced PI3K-S6 kinase signaling, and phosphorylated USP11 further enhances its interaction with eIF4B and thereby promoting oncogenic translation [37], implying that the activity of deubiquitinase USP11 is also activated by the kinase and enriches the complex regulatory network of USP11."
EGFR-vIII affects USP11
|
2
EGFR-vIII mutation affects USP11
|
2
EGFR-vIII activation affects USP11
|
2
sparser
"To determine which binding pocket was used to mediate the interactions with USP11, PPM1G, DHX40, DDX24 and TRIP12, we repeated the myc-USP7 co-IP experiments in CNE2Z cells, using USP7 mutants with D164A,W165A mutations to disrupt the TRAF binding pocket (referred to as DW) or D762R,D764R mutations to disrupt the Ubl2 pocket (referred to as Ubl2)."
sparser
"Comparison of protein recoveries with individual DW and Ubl2 USP7 mutants showed that interactions with PPM1G, USP11, DDX24 and TRIP12 were greatly affected by the DW mutation and much less affected by the Ubl2 mutation, indicating that these proteins all interact predominantly bind USP7 through the TRAF binding pocket."
CS affects USP11
|
2
17beta-estradiol affects USP11
|
2
USP11 affects histone deubiquitination
|
1
USP11 activates histone deubiquitination. 1 / 1
|
1
USP11 affects hiPSCs-SFTPC -AOs
|
1
USP11 affects cells being more 5-Fu
|
1
reach
"USP11 KD also reduced transcript levels of the AR targets KLK2, KLK3, NKX3-1, TMPRSS2, SLC45A3, and PMEPA1 in Rv1 (SI Appendix, Fig. S2H), VCaP (SI Appendix, Fig. S2I), and C4-2 (SI Appendix, Fig. S2J) cells, and in Rv1 cells decreased those levels in the presence or absence of androgen (SI Appendix, Fig. S2K)."
USP11 affects ICH-like symptoms
|
1
USP11 affects Huntington Disease
|
1
USP11 inhibits Huntington Disease. 1 / 1
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1
USP11 affects DNA Breaks, Double-Stranded
|
1
USP11 activates DNA Breaks, Double-Stranded. 1 / 1
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1
reach
"Here, we identify the deubiquitylating enzyme USP11 as a previously uncharacterised PRMT1 substrate, and demonstrate that the methylation of USP11 promotes DNA end-resection and the repair of DNA double strand breaks (DSB) by homologous recombination (HR), an event that is independent from another USP11-HR activity, the deubiquitylation of PALB2."
USP11 affects Carcinoma, Non-Small-Cell Lung
|
1
USP11 inhibits Carcinoma, Non-Small-Cell Lung. 1 / 1
|
1
PI3K-S6 kinase affects USP11
|
1
reach
"Intriguingly, the activity of USP11 could be phosphorylated by FASN-induced PI3K-S6 kinase signaling, and phosphorylated USP11 further enhances its interaction with eIF4B and thereby promoting oncogenic translation [37], implying that the activity of deubiquitinase USP11 is also activated by the kinase and enriches the complex regulatory network of USP11."
FK228 treatment affects USP11
|
1