IndraLab
Statements
reach
"For example, USP10 regulates Notch signaling pathway in the endothelium [23]; USP10 protects against cerebral ischemia injury by attenuating inflammation and apoptosis through inhibiting the TAK1 signaling pathway [8]; Interaction of USP10 and G3BP2 blocks p53 signaling and results in poor prognosis in prostate cancer [24]; Wu-5, which is an inhibitor of USP10, enhances crenolanib-induced FLT3-ITD-positive AML cell death by suppressing FLT3 and AMPK signaling pathways [25]."
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
USP10 is modified
45
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74
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USP10 is phosphorylated.
45
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73
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sparser
"To further clarify that anti-μ antibody and Pam 3 Csk 4 co-treatment promoted T674 phosphorylation of USP10, we first generated an antibody that specifically recognizes the phosphorylation site of USP10 by immunizing rabbits with the phosphorylated and sequence-homologous polypeptides (Supplementary Fig. xref )."
sparser
"AMPKα AMPKα increases its activity by mediating phosphorylation of Ser76 at the USP10 N-terminus.
[15]
ATM ATM mediates phosphorylation of USP10 at Thr42 and Ser337 and causes USP10's migration into the nucleus.
[27]
TRAF4 TRAF4 and p53 competitively bind to USP10 and inhibit usP10-mediated p53 deubiquitination. [73] AKT Co-stimulation by BCR and TLR1/2 initiates Akt-dependent phosphorylation of T674 in the USP10 NLS domain.
[72]
USP13/beclin-1
When USP10 and USP13 interact with beclin-1, the deubiquitination activity of USP10 can be increased.
[53]
MiR-138
MiR-138 binds to a conserved region of USP10's 3 -UTR and inhibits the accumulation of USP10 mRNA and protein expression level.
[31]
MicroRNA-191
MicroRNA-191 binds to the 3 -untranslated region of USP10 mRNA, reducing USP10 protein levels.
[28]
MiR-34a-5p MiR-34a-5p binds to the 3 -untranslated region of USP10 and reduces the expression of USP10. [79] G3BP Direct binding of G3BP to USP10 inhibits its ability to decompose ubiquitin chains. [56] HTLV-1 Tax
The central region of Tax interacts with amino acids 727-798 in USP10, inhibiting the activity of USP10.
[78]
Daam1 negatively regulates USP10's DUB activity. [80] Estrogen Estrogen induces p53 degradation by regulating USP10 activity.
[81]
Overexpressed FOXO4 inhibits USP10 transcription and protein expression by binding to the bases 1771-1776 in the promoter region TSS of USP10. [82] Zhang et al. indicated that miR-34a-5p acted as a negative regulator of USP10, but the underlying mechanism of the microRNA's action remains largely unclear [79] ."
sparser
"AMPKα AMPKα increases its activity by mediating phosphorylation of Ser76 at the USP10 N-terminus.
[15]
ATM ATM mediates phosphorylation of USP10 at Thr42 and Ser337 and causes USP10's migration into the nucleus.
[27]
TRAF4 TRAF4 and p53 competitively bind to USP10 and inhibit usP10-mediated p53 deubiquitination. [73] AKT Co-stimulation by BCR and TLR1/2 initiates Akt-dependent phosphorylation of T674 in the USP10 NLS domain.
[72]
USP13/beclin-1
When USP10 and USP13 interact with beclin-1, the deubiquitination activity of USP10 can be increased.
[53]
MiR-138
MiR-138 binds to a conserved region of USP10's 3 -UTR and inhibits the accumulation of USP10 mRNA and protein expression level.
[31]
MicroRNA-191
MicroRNA-191 binds to the 3 -untranslated region of USP10 mRNA, reducing USP10 protein levels.
[28]
MiR-34a-5p MiR-34a-5p binds to the 3 -untranslated region of USP10 and reduces the expression of USP10. [79] G3BP Direct binding of G3BP to USP10 inhibits its ability to decompose ubiquitin chains. [56] HTLV-1 Tax
The central region of Tax interacts with amino acids 727-798 in USP10, inhibiting the activity of USP10.
[78]
Daam1 negatively regulates USP10's DUB activity. [80] Estrogen Estrogen induces p53 degradation by regulating USP10 activity.
[81]
Overexpressed FOXO4 inhibits USP10 transcription and protein expression by binding to the bases 1771-1776 in the promoter region TSS of USP10. [82] Zhang et al. indicated that miR-34a-5p acted as a negative regulator of USP10, but the underlying mechanism of the microRNA's action remains largely unclear [79] ."
sparser
"AMPKα AMPKα increases its activity by mediating phosphorylation of Ser76 at the USP10 N-terminus.
[15]
ATM ATM mediates phosphorylation of USP10 at Thr42 and Ser337 and causes USP10's migration into the nucleus.
[27]
TRAF4 TRAF4 and p53 competitively bind to USP10 and inhibit usP10-mediated p53 deubiquitination. [73] AKT Co-stimulation by BCR and TLR1/2 initiates Akt-dependent phosphorylation of T674 in the USP10 NLS domain.
[72]
USP13/beclin-1
When USP10 and USP13 interact with beclin-1, the deubiquitination activity of USP10 can be increased.
[53]
MiR-138
MiR-138 binds to a conserved region of USP10's 3 -UTR and inhibits the accumulation of USP10 mRNA and protein expression level.
[31]
MicroRNA-191
MicroRNA-191 binds to the 3 -untranslated region of USP10 mRNA, reducing USP10 protein levels.
[28]
MiR-34a-5p MiR-34a-5p binds to the 3 -untranslated region of USP10 and reduces the expression of USP10. [79] G3BP Direct binding of G3BP to USP10 inhibits its ability to decompose ubiquitin chains. [56] HTLV-1 Tax
The central region of Tax interacts with amino acids 727-798 in USP10, inhibiting the activity of USP10.
[78]
Daam1 negatively regulates USP10's DUB activity. [80] Estrogen Estrogen induces p53 degradation by regulating USP10 activity.
[81]
Overexpressed FOXO4 inhibits USP10 transcription and protein expression by binding to the bases 1771-1776 in the promoter region TSS of USP10. [82] Zhang et al. indicated that miR-34a-5p acted as a negative regulator of USP10, but the underlying mechanism of the microRNA's action remains largely unclear [79] ."
USP10 is ubiquitinated.
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1
USP10 affects apoptotic process
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USP10 inhibits apoptotic process.
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USP10 activates apoptotic process.
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reach
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [XREF_BIBR, XREF_BIBR]."
sparser
"Nancy presented preliminary data indicating differential regulation of SG nucleation by these G3BP1 binding partners, whereby Caprin1 and USP10 bind the G3BP-NTF2-like domain in a competitive manner, with opposite results; G3BP1:Caprin1 complexes promote SG formation, whereas G3BP1:USP10 complexes inhibit SG formation."
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
sparser
"These are the same domains that are necessary for the formation of SGs under conditions of cellular stress, the NTF2-like domain is needed for homodimerisation as well as binding to caprin-1 and USP10, the positive and negative regulators of SGs, while the RGG region mediates binding to the 40S ribosomal subunits [ xref ]."
reach
"For example, UCH-L3 localizes to endosomes and regulates the surface levels of ENaC in kidney cells, USP-10 localizes to endosomes and promotes CFTR recycling to the epithelial cell surface, USP20 and USP33 control recycling of beta 2 ARs, and both AMSH and USP8 and UBPY are endosome associated DUBs implicated in regulating EGFR degradation."
reach
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [XREF_BIBR, XREF_BIBR]."
sparser
"Nancy presented preliminary data indicating differential regulation of SG nucleation by these G3BP1 binding partners, whereby Caprin1 and USP10 bind the G3BP-NTF2-like domain in a competitive manner, with opposite results; G3BP1:Caprin1 complexes promote SG formation, whereas G3BP1:USP10 complexes inhibit SG formation."
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
sparser
"These are the same domains that are necessary for the formation of SGs under conditions of cellular stress, the NTF2-like domain is needed for homodimerisation as well as binding to caprin-1 and USP10, the positive and negative regulators of SGs, while the RGG region mediates binding to the 40S ribosomal subunits [ xref ]."
USP10 affects cell population proliferation
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USP10 activates cell population proliferation.
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USP10 inhibits cell population proliferation.
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USP10 inhibits cell population proliferation. 10 / 15
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"Next, we treated infected THP-1 cells with a cell-permeable potent autophagy inhibitor, spautin-1.58 Spautin-1 promotes the degradation of BECN1 by inhibiting 2 USPs (ubiquitin-specific peptidases), USP10 and USP13, which target BECN1.58 Spautin-1 treatment of infected cells significantly decreased E. chaffeensis proliferation (Fig. 3B)."
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reach
"Cell based transactivation assays in PC-3/AR cells revealed that overexpression of wild-type USP10, but not of an enzymatically inactive form, stimulated AR activity mediated by reporter constructs harbouring selective androgen response elements (AREs), non selective steroid response elements (SREs) or the mouse mammary tumour virus (MMTV) promoter."
sparser
"For example, USP10 interacts with G3BP2 to block p53 signal transduction, leading to poor prognosis in prostate cancer [ xref ]; USP44 promotes the development of prostate cancer by stabilizing EZH2 [ xref ], and USP2a enhances c-Myc expression via microRNA-related regulation and thus promotes tumourigenesis [ xref ]."
reach
"For example, USP10 interacts with G3BP2 to block p53 signal transduction, leading to poor prognosis in prostate cancer [XREF_BIBR]; USP44 promotes the development of prostate cancer by stabilizing EZH2 [XREF_BIBR], and USP2a enhances c-Myc expression via microRNA related regulation and thus promotes tumourigenesis [XREF_BIBR]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
reach
"Expression of GFP-USP10 (lanes 4-6 and 16-18) increases G3BP2 expression (XREF_FIG, lanes 10-12 vs. 7-9), but the increased G3BP2 is not precipitated by B-isox (lanes 4-6), suggesting that B-isox binds and/or precipitates a SG-competent form of G3BP that is rendered SG-incompetent and B-isox soluble upon USP10 binding."
USP10 affects Circulin-C
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USP10 binds Circulin-C. 10 / 28
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sparser
"Furthermore, a subnetwork regulating microglial/macrophage activation that contained circ_0014637 (circ-Usp10), 5 miRNAs (miR-149, miR-152, miR-7033, miR-709 and miR-6963) and 8 target genes (Sbno2, Thbs1Cx3cr1, Cd300a, Il4ra, Syk, Ctsc, Cd84, and Sbno2) was further screened ( xref ))."
reach
"On the other hand, autophagy can be also inhibited blocking PI3KC3 complex formation; Spautin-1 indirectly inhibits the activity of VPS34 by proteosomal degradation of proteins that form VPS34 complexes through reduction of Beclin-1 deubiquitination mediated by USP10 and USP13 [120]."
reach
"Conversely, it was show that Beclin 1 is deubiquitinated by USP10 and USP13 and adding complexity, Beclin 1 itself controlled the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities, in turn regulating the levels of tumor suppressor p53 [XREF_BIBR]."
"While A20 inhibits PtdIns3P signaling by removing the TRAF6-dependent Lys63-linked chains from Beclin 1, the enzymes USP10 and USP13 prevent PI3K-III complex components from their degradation and, therefore, support autophagy. Interestingly enough, USP10 also stabilizes p53, which, in turn, triggers the degradation of Beclin 1 and VPS34 in order to prevent autophagy."
USP10 affects AMPK_alpha
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USP10 binds AMPK_alpha.
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USP10 deubiquitinates AMPK_alpha.
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USP10 phosphorylates AMPK_alpha.
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USP10 affects cell growth
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USP10 inhibits cell growth.
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USP10 activates cell growth.
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USP10 activates cell growth. 1 / 2
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reach
"Collectively, these results indicated that BCR and TLR2 synergistically enhance Akt activity and promote USP10 T674 phosphorylation located within the NLS domain and, therefore, the nuclear import of USP10, consequently inhibiting the AID degradation in the nucleus.Pam 3 Csk 4 helped to enhance the antibody response to the SARS-CoV-2 RBD nanoparticle vaccine Pam 3 Csk 4 has been used as a vaccine adjuvant."
sparser
"Moreover, usp4-depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [102] Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) cleaves K63-linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to highrisk human papillomavirus (hrHPV) infection. [103] TRAF family member-associated NF-B activator (TANK) interacts with both monocyte chemotactic protein-1-induced protein-1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF-B activation in response to TLR activation. [104] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO-attached M1-linked polyubiquitin chains, thus inhibiting the genotoxic NF-B signaling cascade. [40] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4 ‐depleted zebrafish ( Danio rerio ) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [ xref ] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection. [ xref ] TRAF family member‐associated NF‐ κ B activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐ κ B activation in response to TLR activation. [ xref ] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐ κ B signaling cascade. [ xref ] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4‐depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment.[
102
] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection.[
103
] TRAF family member‐associated NF‐κB activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐κB activation in response to TLR activation.[
104
] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐κB signaling cascade.[
40
] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
USP10 affects cell death
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USP10 inhibits cell death.
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USP10 inhibits cell death. 10 / 15
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reach
"Given that USP10-WT, USP10 C424A, and USP10 96-798, but not USP10 1-214, in USP10-KD cells promoted p62 aggregation and aggresome formation (XREF_FIG G and XREF_SUPPLEMENTARY A-S5C), these results suggested that USP10 inhibits cell death induced by MG-132 by promoting aggresome formation and p62 aggregation."
USP10 activates cell death.
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USP10 activates cell death. 5 / 5
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reach
"In this report, we found that PdPT is an inhibitor of multiple DUBs including USP7, USP10, USP14, USP15, USP25 and UCHL5, which contributes to the accumulation of ubiquitinated proteins and subsequent cell death in NSCLC cell lines.Regulated cell death requires activation of various regulators and effectors (23)."
sparser
"Moreover, usp4-depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [102] Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) cleaves K63-linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to highrisk human papillomavirus (hrHPV) infection. [103] TRAF family member-associated NF-B activator (TANK) interacts with both monocyte chemotactic protein-1-induced protein-1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF-B activation in response to TLR activation. [104] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO-attached M1-linked polyubiquitin chains, thus inhibiting the genotoxic NF-B signaling cascade. [40] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4 ‐depleted zebrafish ( Danio rerio ) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [ xref ] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection. [ xref ] TRAF family member‐associated NF‐ κ B activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐ κ B activation in response to TLR activation. [ xref ] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐ κ B signaling cascade. [ xref ] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4‐depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment.[
102
] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection.[
103
] TRAF family member‐associated NF‐κB activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐κB activation in response to TLR activation.[
104
] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐κB signaling cascade.[
40
] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
USP10 affects Neoplasm Metastasis
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USP10 activates Neoplasm Metastasis. 10 / 18
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reach
"In the current study, we found that there was no correlation between expression of TM4SF1 and USP10, S100A12, p53, or Ki67 expression in GC, suggesting that TM4SF1 plays a distinct role in GC invasion and metastasis from those of USP10, S100A12, p53, or Ki67, although they all contribute to cancer invasion and metastasis."
reach
"As shown in Fig. S5D, the protein levels of USP10 were more abundant and highly correlated with Smad4 expression in tumorous regions compared with that in nontumorous tissues.These results demonstrate that USP10 reinforces the TGF‐β signaling and promotes the metastasis of HCC cells."
reach
"Moreover, ablation of USP10 by either shRNAs or USP10 inhibitor Spautin‐1 significantly suppresses the metastasis of HCC cells in vitro and/or in vivo, whereas the reconstitution of Smad4 was able to efficiently rescue this defect, indicating that targeting USP10 could be a novel therapeutic strategy of metastatic HCC displaying high level of Smad4.2
Materials and methods."
USP10 bound to it activates Neoplasm Metastasis. 2 / 2
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sparser
"For example, USP10 interacts with G3BP2 to block p53 signal transduction, leading to poor prognosis in prostate cancer [ xref ]; USP44 promotes the development of prostate cancer by stabilizing EZH2 [ xref ], and USP2a enhances c-Myc expression via microRNA-related regulation and thus promotes tumourigenesis [ xref ]."
reach
"For example, USP10 interacts with G3BP2 to block p53 signal transduction, leading to poor prognosis in prostate cancer [XREF_BIBR]; USP44 promotes the development of prostate cancer by stabilizing EZH2 [XREF_BIBR], and USP2a enhances c-Myc expression via microRNA related regulation and thus promotes tumourigenesis [XREF_BIBR]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
reach
"Although no structural information for USP13 and USP10 is currently available, the enhanced DUB activity when USP13 interacts with USP10 or when they interact with Beclin1 suggest that the interaction of USP13 and USP10 with each other or with their substrates can lead to changes in their conformation which may be critical for the catalytic activities."
sparser
"Although no structural information for USP13 and USP10 is currently available, the enhanced DUB activity when USP13 interacts with USP10 or when they interact with Beclin1 suggest that the interaction of USP13 and USP10 with each other or with their substrates can lead to changes in their conformation which may be critical for the catalytic activities."
reach
"It will be interesting to elucidate if the stability of the other PI3K and III complex members is also affected, as in the case of Spautin-1 -- mediated inhibition of USP10 and USP13 [XREF_BIBR] and if the control of Beclin 1 stability is mediated by HSP90 in general or whether this represents a regulatory event specifically developed in phagocytic cells."
reach
"The data in our report demonstrated that ATO treatment reduces the binding of USP10 to FLT3 protein, which might partly contribute to the enhanced ubiquitination of mutant FLT3 protein.Hsp90 is an important chaperone molecule assisting in folding and preventing client proteins from ubiquitination and degradation [44]."
"USP10, a primary cytoplasmic DUB, acts as an oncogene or a tumor suppressor by regulating various protein substrates, including FLT3, p53, AMPK, PTEN, etc."
reach
"However, in acute myeloid leukemia (AML) patients with activating mutations in FMS‐like tyrosine kinase 3 (FLT3), USP10 deubiquitinates and stabilizes FLT3 by removing the proteolytic polyubiquitin chains and preventing FLT3 degradation, to aggravate tumor progress (Weisberg et al., 2017)."
reach
"Given our recent finding that USP10 deubiquitinates mutant FLT3, 18 coupled with reported studies showing that FLT3 and SYK are interacting partners with each other and are targets of the same E3 ligase c-CBL, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR we hypothesised that USP10 may play a role in stabilisation of SYK."
Spautin-1 decreases the amount of USP10.
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2
Spautin-1 binds USP10.
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2
Spautin-1 activates USP10.
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2
reach
"Because the reductions in the levels of USP10 and USP13 in H4-LC3-GFP cells treated with spautin-1 appeared later than the reductions in the levels of Vps34 complexes and autophagy (XREF_FIG), the reduced levels of USP10 and USP13 are unlikely to be the primary reason for the ability of spautin-1 to reduce the levels of PtdIns3P and inhibit autophagy."
sparser
"Moreover, usp4-depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [102] Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) cleaves K63-linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to highrisk human papillomavirus (hrHPV) infection. [103] TRAF family member-associated NF-B activator (TANK) interacts with both monocyte chemotactic protein-1-induced protein-1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF-B activation in response to TLR activation. [104] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO-attached M1-linked polyubiquitin chains, thus inhibiting the genotoxic NF-B signaling cascade. [40] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4 ‐depleted zebrafish ( Danio rerio ) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [ xref ] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection. [ xref ] TRAF family member‐associated NF‐ κ B activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐ κ B activation in response to TLR activation. [ xref ] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐ κ B signaling cascade. [ xref ] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4‐depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment.[
102
] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection.[
103
] TRAF family member‐associated NF‐κB activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐κB activation in response to TLR activation.[
104
] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐κB signaling cascade.[
40
] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
reach
"A study by Liu et al. (Liu et al., 2011) has demonstrated that Spautin-1 is a potent small-molecule inhibitor of USP10 and USP13, and treatment with Spautin-1 inhibits the deubiquitinase activity of USP10 and USP13, resulting in an increasing ubiquitination and accelerating degradation of Beclin1 in Vps34 complexes, ultimately inhibiting autophagy."
Spautin-1 activates USP10.
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4
reach
"Additionally, Liao and colleagues [XREF_BIBR] found that USP10 can promote leukemic cell proliferation by deubiquitinating and stabilizing the S-phase kinase associated protein 2 (SKP2) that acts as a co-regulator of BCR-ABL mediating its K63 linked ubiquitination and activation in CML cells [XREF_BIBR]."
USP10 affects inflammatory response
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5
8
USP10 inhibits inflammatory response.
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3
7
USP10 inhibits inflammatory response. 10 / 10
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3
7
eidos
"USP10 Inhibited Inflammation and Apoptosis in Hepatocytes After H / R Treatment To validate whether USP10 directly influences inflammation and apoptosis in hepatocytes , we detected inflammation and apoptosis in H / R-treated primary hepatocytes isolated from USP10-HZ and WT mice ."
USP10 activates inflammatory response.
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2
1
sparser
"Moreover, hematoxylin and eosin and Picrosirius red staining of heart sections indicated that compared with those of their USP10‐Flox littermates, hearts from USP10‐CKO mice developed significant cardiomyocyte hypertrophy and fibrosis in the interstitial and perivascular spaces (Figure xref through xref )."
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
sparser
"Moreover, hematoxylin and eosin and Picrosirius red staining of heart sections indicated that compared with those of their USP10‐Flox littermates, hearts from USP10‐CKO mice developed significant cardiomyocyte hypertrophy and fibrosis in the interstitial and perivascular spaces (Figure xref through xref )."
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
reach
"Although no structural information for USP13 and USP10 is currently available, the enhanced DUB activity when USP13 interacts with USP10 or when they interact with Beclin1 suggest that the interaction of USP13 and USP10 with each other or with their substrates can lead to changes in their conformation which may be critical for the catalytic activities."
sparser
"Although no structural information for USP13 and USP10 is currently available, the enhanced DUB activity when USP13 interacts with USP10 or when they interact with Beclin1 suggest that the interaction of USP13 and USP10 with each other or with their substrates can lead to changes in their conformation which may be critical for the catalytic activities."
reach
"As shown in Fig. S5D, the protein levels of USP10 were more abundant and highly correlated with Smad4 expression in tumorous regions compared with that in nontumorous tissues.These results demonstrate that USP10 reinforces the TGF‐β signaling and promotes the metastasis of HCC cells."
reach
"Moreover, ablation of USP10 by either shRNAs or USP10 inhibitor Spautin‐1 significantly suppresses the metastasis of HCC cells in vitro and/or in vivo, whereas the reconstitution of Smad4 was able to efficiently rescue this defect, indicating that targeting USP10 could be a novel therapeutic strategy of metastatic HCC displaying high level of Smad4.2
Materials and methods."
reach
"Furthermore, we demonstrate that depletion of USP10 or depriving of its catalytic activity with small‐molecule inhibitor Spautin‐1 significantly represses the metastasis of HCC cells in vitro and/or in vivo, whereas the reconstitution of Smad4 was able to efficiently rescue this defect."
AMPK_alpha affects USP10
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7
5
USP10 affects Neoplasm Invasiveness
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4
7
USP10 inhibits Neoplasm Invasiveness.
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4
5
USP10 activates Neoplasm Invasiveness.
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2
USP10 activates Neoplasm Invasiveness. 2 / 2
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2
reach
"In the current study, we found that there was no correlation between expression of TM4SF1 and USP10, S100A12, p53, or Ki67 expression in GC, suggesting that TM4SF1 plays a distinct role in GC invasion and metastasis from those of USP10, S100A12, p53, or Ki67, although they all contribute to cancer invasion and metastasis."
reach
"The close functional interconnection between the central PI3K-III subunits and the DUBs is demonstrated by the interesting observation that knock-down of VPS34 and Beclin 1 causes instability of USP10 and USP13, which strongly indicates the existence of a regulatory feedback loop [XREF_BIBR]."
reach
"A curved arrowhead with a black color indicates positive regulation.In addition to USP10 being regulated by the proteins of host cells, previous studies of the Takahashi group showed that HTLV-1 Tax interacted with amino acids 727–798 at the C-terminal of USP10 and inhibited USP10’s deubiquitination activity and function."
sparser
"The association of ubiquitin with neurofibrillary tangles is also well documented, xref in line with shreds of evidence related to Ubiquitin‐specific protease 10 (USP10) as a crucial factor for the formation of SGs comprising tau, TIA‐1, and USP10. xref USP10 also colocalizes with aggregated tau in AD patients' brain lesions, xref suggesting its role in SG mediated tau aggregation."
reach
"A curved arrowhead with a black color indicates positive regulation.In addition to USP10 being regulated by the proteins of host cells, previous studies of the Takahashi group showed that HTLV-1 Tax interacted with amino acids 727–798 at the C-terminal of USP10 and inhibited USP10’s deubiquitination activity and function."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
USP10 affects reactive oxygen species
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8
1
USP10 inhibits reactive oxygen species.
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4
1
USP10 activates reactive oxygen species.
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4
USP10 affects DnaK
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2
7
reach
"We demonstrate that mycoplasma DnaK interacts with and reduces the activities of human proteins involved in critical cellular pathways, including DNA-PK and PARP1, which are required for efficient DNA repair, and binds to USP10 (a key p53 regulator), impairing p53 dependent anticancer functions."
sparser
"We demonstrated that this mycoplasma’s DnaK binds to human USP10 (ubiquitin carboxyl-terminal hydrolase 10, a regulator of p53 stability), reducing p53 stability and anti-cancer functions, potentially increasing the likelihood of DNA mutations and consequent malignant transformation [ xref ]."
reach
"We demonstrated that this mycoplasma’s DnaK binds to human USP10 (ubiquitin carboxyl-terminal hydrolase 10, a regulator of p53 stability), reducing p53 stability and anti-cancer functions, potentially increasing the likelihood of DNA mutations and consequent malignant transformation [107]."
sparser
"Moreover, usp4-depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [102] Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) cleaves K63-linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to highrisk human papillomavirus (hrHPV) infection. [103] TRAF family member-associated NF-B activator (TANK) interacts with both monocyte chemotactic protein-1-induced protein-1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF-B activation in response to TLR activation. [104] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO-attached M1-linked polyubiquitin chains, thus inhibiting the genotoxic NF-B signaling cascade. [40] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4 ‐depleted zebrafish ( Danio rerio ) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [ xref ] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection. [ xref ] TRAF family member‐associated NF‐ κ B activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐ κ B activation in response to TLR activation. [ xref ] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐ κ B signaling cascade. [ xref ] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4‐depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment.[
102
] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection.[
103
] TRAF family member‐associated NF‐κB activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐κB activation in response to TLR activation.[
104
] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐κB signaling cascade.[
40
] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
DnaK affects USP10
|
2
7
reach
"We demonstrate that mycoplasma DnaK interacts with and reduces the activities of human proteins involved in critical cellular pathways, including DNA-PK and PARP1, which are required for efficient DNA repair, and binds to USP10 (a key p53 regulator), impairing p53 dependent anticancer functions."
sparser
"We demonstrated that this mycoplasma’s DnaK binds to human USP10 (ubiquitin carboxyl-terminal hydrolase 10, a regulator of p53 stability), reducing p53 stability and anti-cancer functions, potentially increasing the likelihood of DNA mutations and consequent malignant transformation [ xref ]."
reach
"We demonstrated that this mycoplasma’s DnaK binds to human USP10 (ubiquitin carboxyl-terminal hydrolase 10, a regulator of p53 stability), reducing p53 stability and anti-cancer functions, potentially increasing the likelihood of DNA mutations and consequent malignant transformation [107]."
reach
"Because the reductions in the levels of USP10 and USP13 in H4-LC3-GFP cells treated with spautin-1 appeared later than the reductions in the levels of Vps34 complexes and autophagy (XREF_FIG), the reduced levels of USP10 and USP13 are unlikely to be the primary reason for the ability of spautin-1 to reduce the levels of PtdIns3P and inhibit autophagy."
sparser
"It was reported that EIF4G1 interacted with the ubiquitin USP10, as shown by tandem affinity purification and mass spectrometry; USP10 is located in the cytoplasm, and USP10 had been shown to be able to specifically ubiquitin and stabilize p53, thereby regulating p53‐dependent downstream function. xref , xref , xref To date, p53 is one of the most important tumour suppressor factors. xref As a transcription factor, p53 regulates a variety of cytological responses by regulating downstream target genes. xref , xref For example, p53 regulates cell cycle G1 arrest by acting on the CDK inhibitory factor p21, cell apoptosis by acting on bax, energy metabolism by acting on TIGAR of glycolysis, and autophagy by acting on AMPK."
sparser
"The association of ubiquitin with neurofibrillary tangles is also well documented, xref in line with shreds of evidence related to Ubiquitin‐specific protease 10 (USP10) as a crucial factor for the formation of SGs comprising tau, TIA‐1, and USP10. xref USP10 also colocalizes with aggregated tau in AD patients' brain lesions, xref suggesting its role in SG mediated tau aggregation."
reach
"The data in our report demonstrated that ATO treatment reduces the binding of USP10 to FLT3 protein, which might partly contribute to the enhanced ubiquitination of mutant FLT3 protein.Hsp90 is an important chaperone molecule assisting in folding and preventing client proteins from ubiquitination and degradation [44]."
sparser
"It was reported that EIF4G1 interacted with the ubiquitin USP10, as shown by tandem affinity purification and mass spectrometry; USP10 is located in the cytoplasm, and USP10 had been shown to be able to specifically ubiquitin and stabilize p53, thereby regulating p53‐dependent downstream function. xref , xref , xref To date, p53 is one of the most important tumour suppressor factors. xref As a transcription factor, p53 regulates a variety of cytological responses by regulating downstream target genes. xref , xref For example, p53 regulates cell cycle G1 arrest by acting on the CDK inhibitory factor p21, cell apoptosis by acting on bax, energy metabolism by acting on TIGAR of glycolysis, and autophagy by acting on AMPK."
USP10 affects TOP2alpha
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7
P22077 affects USP10
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2
5
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
sparser
"Moreover, hematoxylin and eosin and Picrosirius red staining of heart sections indicated that compared with those of their USP10‐Flox littermates, hearts from USP10‐CKO mice developed significant cardiomyocyte hypertrophy and fibrosis in the interstitial and perivascular spaces (Figure xref through xref )."
USP10 affects hepatic steatosis
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6
USP10 inhibits hepatic steatosis.
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4
eidos
"In a non-alcoholic fatty liver disease model , USP10 inhibits hepatic steatosis , insulin resistance , and the inflammatory response by interacting with SIRT6 and inhibiting its ubiquitination and degradation ( 6 ) , and USP10 inhibition also abolishes Mirt2 ( long non-coding RNA myocardial infarction associated transcript 2 ) overexpression-induced suppression of glucose production and lipogenesis in hepatocytes ( 7 ) ."
USP10 activates hepatic steatosis.
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2
sparser
"Moreover, hematoxylin and eosin and Picrosirius red staining of heart sections indicated that compared with those of their USP10‐Flox littermates, hearts from USP10‐CKO mice developed significant cardiomyocyte hypertrophy and fibrosis in the interstitial and perivascular spaces (Figure xref through xref )."
USP10 affects TOP2α
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6
USP10 affects Proteasome
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5
TOP2α affects USP10
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6
reach
"Using an imaging-based screen, Liu et al. (2011) recently identified a highly potent small molecule inhibitor of autophagy they named spautin-1 (specific and potent autophagy inhibitor 1), which promotes degradation of the Vps34 complexes via inhibiting ubiquitin-specific processing protease 10 (USP10) and USP13, two ubiquitin-specific peptidases that target the deubiquitination of Beclin1.2."
reach
"The close functional interconnection between the central PI3K-III subunits and the DUBs is demonstrated by the interesting observation that knock-down of VPS34 and Beclin 1 causes instability of USP10 and USP13, which strongly indicates the existence of a regulatory feedback loop [XREF_BIBR]."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
USP10 affects LPS-induced renal tubular epithelial cell injury
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5
USP10 affects Insulin Resistance
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4
1
USP10 inhibits Insulin Resistance. 5 / 5
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4
1
eidos
"In a non-alcoholic fatty liver disease model , USP10 inhibits hepatic steatosis , insulin resistance , and the inflammatory response by interacting with SIRT6 and inhibiting its ubiquitination and degradation ( 6 ) , and USP10 inhibition also abolishes Mirt2 ( long non-coding RNA myocardial infarction associated transcript 2 ) overexpression-induced suppression of glucose production and lipogenesis in hepatocytes ( 7 ) ."
USP10 affects Cell Survival
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5
USP10 activates Cell Survival.
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3
USP10 inhibits Cell Survival.
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2
Pirinixic acid affects USP10
4
|
Cycle inhibiting factor (Cif) affects USP10
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4
sparser
"Moreover, usp4-depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [102] Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) cleaves K63-linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to highrisk human papillomavirus (hrHPV) infection. [103] TRAF family member-associated NF-B activator (TANK) interacts with both monocyte chemotactic protein-1-induced protein-1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF-B activation in response to TLR activation. [104] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO-attached M1-linked polyubiquitin chains, thus inhibiting the genotoxic NF-B signaling cascade. [40] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4 ‐depleted zebrafish ( Danio rerio ) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [ xref ] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection. [ xref ] TRAF family member‐associated NF‐ κ B activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐ κ B activation in response to TLR activation. [ xref ] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐ κ B signaling cascade. [ xref ] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4‐depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment.[
102
] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection.[
103
] TRAF family member‐associated NF‐κB activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐κB activation in response to TLR activation.[
104
] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐κB signaling cascade.[
40
] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
USP7 affects NHE3
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4
USP10 affects c-Myc oncogene
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4
USP10 affects NHE3
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4
USP10 affects LC3B
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4
USP10 affects Carcinogenesis
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4
USP10 inhibits Carcinogenesis.
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2
USP10 activates Carcinogenesis.
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2
TOP2alpha affects USP10
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4
NHE3 affects USP7
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4
sparser
"Moreover, usp4-depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [102] Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) cleaves K63-linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to highrisk human papillomavirus (hrHPV) infection. [103] TRAF family member-associated NF-B activator (TANK) interacts with both monocyte chemotactic protein-1-induced protein-1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF-B activation in response to TLR activation. [104] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO-attached M1-linked polyubiquitin chains, thus inhibiting the genotoxic NF-B signaling cascade. [40] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4 ‐depleted zebrafish ( Danio rerio ) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [ xref ] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection. [ xref ] TRAF family member‐associated NF‐ κ B activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐ κ B activation in response to TLR activation. [ xref ] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐ κ B signaling cascade. [ xref ] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
sparser
"Moreover, usp4‐depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment.[
102
] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection.[
103
] TRAF family member‐associated NF‐κB activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐κB activation in response to TLR activation.[
104
] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐κB signaling cascade.[
40
] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."
Vasopressin affects USP10
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3
MiR-138 affects USP10
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3
Bisphenol A affects USP10
3
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Bisphenol A increases the amount of USP10.
2
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Bisphenol A decreases the amount of USP10.
1
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Anti-μ antibody affects USP10
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3
reach
"To further clarify that anti-μ antibody and Pam3Csk4 co-treatment promoted T674 phosphorylation of USP10, we first generated an antibody that specifically recognizes the phosphorylation site of USP10 by immunizing rabbits with the phosphorylated and sequence-homologous polypeptides (Supplementary Fig. 4a)."
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3
USP10 affects cytoplasmic stress granule
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3
USP10 affects cell migration
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3
USP10 affects activity
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3
USP10 affects H2Aub1
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3
USP10 affects G3BP1/2
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3
reach
"We now show that (a) deletion of G3BP1/2 ablates SGs triggered by p-eIF2alpha or eIF4A inhibition, but not those induced by hyperosmolarity or severe heat shock, (b) the phosphomimetic G3BP1-S149E fails to rescue SG competence, (c) binding of G3BP to Caprin1 or USP10 is not required for SG competence, but may alter G3BP and USP10 protein levels, (d) Caprin1 and USP10 bind G3BP1/2 in a mutually exclusive manner with antagonistic effects on SGs, (e) G3BP1 interacts with 40S ribosomal subunits through its RGG motif, which is required for SG competence, (f) overexpression of USP10 inhibits SG formation downstream of polysome disassembly, and (g) USP10 and FGDF binding to G3BP specifically alters the B-isox precipitation of G3BP1/2 and Caprin1, but not that of other SG associated proteins."
USP10 affects Foam Cells
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3
USP10 activates Foam Cells. 3 / 3
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3
sparser
"To determine whether ubiquitinated NP is specifically deubiquitinated by USP11, we co-transfected plasmids that can express NP-HA, Myc-Ub and Flag-USP10 or USP11, and then subjected HA-tagged immunoprecipitates to immunoblot analysis using the indicated antibodies ( Figure 5D )."
sparser
"Moreover, ectopic expression of Flag-USP10 resulted in dose-dependent elevation of HA-HDAC7 in HEK-293T cells (Fig. xref b), whereas USP10 knockdown markedly increased HDAC7 polyubiquitination and decreased the HDAC7 protein expression without influencing the HDAC7 mRNA levels in EC109 cells (Fig. xref c, d)."
USP10 affects Beclin1 subunit
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3
reach
"We treated TBEV infected neuroblastoma cells with rapamycin (inducer of autophagy, as inhibition of mTOR mimics cellular starvation by blocking signals required for cell growth and proliferation), and spautin-1 (highly specific and potent autophagy inhibitor in mammalian cells, which promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13 that target the Beclin1 subunit of Vps34 complexes) and investigated the effect of the treatment of TBEV growth."
Receptors, Antigen, B-Cell affects USP10
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3
Receptors, Antigen, B-Cell leads to the phosphorylation of USP10 on T674. 3 / 3
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3
reach
"Collectively, these results indicated that BCR and TLR2 synergistically enhance Akt activity and promote USP10 T674 phosphorylation located within the NLS domain and, therefore, the nuclear import of USP10, consequently inhibiting the AID degradation in the nucleus.Pam3Csk4 has been used as a vaccine adjuvant.59 To explore the effect of Pam3Csk4 on the SARS-CoV-2 RBD particle vaccine immune response, USP10-BWT and USP10-BKO mice were immunized with adjuvants in combination with the SARS-CoV-2 RBD particle vaccine."
reach
"Collectively, these results indicated that BCR and TLR2 synergistically enhance Akt activity and promote USP10 T674 phosphorylation located within the NLS domain and, therefore, the nuclear import of USP10, consequently inhibiting the AID degradation in the nucleus.Pam 3 Csk 4 helped to enhance the antibody response to the SARS-CoV-2 RBD nanoparticle vaccine Pam 3 Csk 4 has been used as a vaccine adjuvant."
PTEN affects AMPK_alpha
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3
HBX19818 affects USP10
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1
2
G3BP1/2 affects USP10
|
3
reach
"We now show that (a) deletion of G3BP1/2 ablates SGs triggered by p-eIF2alpha or eIF4A inhibition, but not those induced by hyperosmolarity or severe heat shock, (b) the phosphomimetic G3BP1-S149E fails to rescue SG competence, (c) binding of G3BP to Caprin1 or USP10 is not required for SG competence, but may alter G3BP and USP10 protein levels, (d) Caprin1 and USP10 bind G3BP1/2 in a mutually exclusive manner with antagonistic effects on SGs, (e) G3BP1 interacts with 40S ribosomal subunits through its RGG motif, which is required for SG competence, (f) overexpression of USP10 inhibits SG formation downstream of polysome disassembly, and (g) USP10 and FGDF binding to G3BP specifically alters the B-isox precipitation of G3BP1/2 and Caprin1, but not that of other SG associated proteins."
sparser
"To determine whether ubiquitinated NP is specifically deubiquitinated by USP11, we co-transfected plasmids that can express NP-HA, Myc-Ub and Flag-USP10 or USP11, and then subjected HA-tagged immunoprecipitates to immunoblot analysis using the indicated antibodies ( Figure 5D )."
sparser
"Moreover, ectopic expression of Flag-USP10 resulted in dose-dependent elevation of HA-HDAC7 in HEK-293T cells (Fig. xref b), whereas USP10 knockdown markedly increased HDAC7 polyubiquitination and decreased the HDAC7 protein expression without influencing the HDAC7 mRNA levels in EC109 cells (Fig. xref c, d)."
AMPK_alpha affects PTEN, and USP10
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3
Yki affects USP10
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2
Tetrachloromethane affects USP10
2
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Resveratrol affects USP10
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1
Resveratrol inhibits USP10. 1 / 2
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1
P53-P359A affects USP10
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2
MiR-34a-5p affects USP10
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2
Leptomycin B affects USP10
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2
Indometacin affects USP10
2
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Autophagy inhibitor affects USP10
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2
Wu-5 affects USP10
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2
reach
"For example, USP10 regulates Notch signaling pathway in the endothelium [23]; USP10 protects against cerebral ischemia injury by attenuating inflammation and apoptosis through inhibiting the TAK1 signaling pathway [8]; Interaction of USP10 and G3BP2 blocks p53 signaling and results in poor prognosis in prostate cancer [24]; Wu-5, which is an inhibitor of USP10, enhances crenolanib-induced FLT3-ITD-positive AML cell death by suppressing FLT3 and AMPK signaling pathways [25]."
Vehicle Emissions affects USP10
2
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USP10 affects yki
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2
USP10 affects xenograft growth
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2
USP10 affects tumor growth
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2
USP10 affects tioguanine
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2
USP10 affects stability
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2
eidos
"For example , USP7 regulates the stability of both p53 and Mdm2 and maintains p53 ubiquitination levels ; 120 USP2 mediates the stability of Mdm2 ; 121 USP10 modulates p53 localization and stability ; 122 OTUB1 abrogates p53 ubiquitination and activates p53.123 Interestingly , USP10 can stabilize both mutated and wild-type p53 , with a dual role in tumorigenesis ."
USP10 affects spautin-1
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2
USP10 affects renal dysfunction induced
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2
USP10 affects pressure overload-induced CH
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2
USP10 affects pathway
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2
USP10 affects pTau aggregation
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2
USP10 affects p53-P359A
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2
USP10 affects p14ARF
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2
USP10 increases the amount of p14ARF. 2 / 2
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2
USP10 affects malignant process
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2
USP10 affects mUb-PCNA
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2
USP10 affects localization
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2
USP10 affects lipid uptake macrophage
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2
USP10 affects inflammation apoptosis
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2
USP10 affects hepatocyte inflammation
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2
USP10 affects hepatocellular carcinoma
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2
USP10 affects hepatic R injury
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2
USP10 affects growth
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1
USP10 affects formation
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2
sparser
"Nancy presented preliminary data indicating differential regulation of SG nucleation by these G3BP1 binding partners, whereby Caprin1 and USP10 bind the G3BP-NTF2-like domain in a competitive manner, with opposite results; G3BP1:Caprin1 complexes promote SG formation, whereas G3BP1:USP10 complexes inhibit SG formation."
USP10 affects degradation
|
2
reach
"As we further tested the role of USP10 in cisplatin sensitivity in a large panel of NSCLC cell lines, surprisingly, we discovered that upon cisplatin treatment the depletion or inhibition of USP10 could lead to two entirely different outcomes: cell survival or apoptosis, depending on the cellular status of TP53—USP10 promotes cisplatin sensitivity in wild-type p53 cells, while USP10 confers cisplatin resistance in mutant p53 cells."
USP10 affects cholesterol
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2
USP10 affects cell cycle
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2
USP10 inhibits cell cycle. 2 / 2
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2
USP10 affects cardiac hypertrophy
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2
USP10 affects assembly
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2
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1
1
USP10 activates actomyosin contractile ring assembly. 2 / 2
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1
1
USP10 affects activation
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2
USP10 affects activation TAK1-JNK p38 signalling
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2
USP10 affects activation NRF2 HO-1 pathway
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2
USP10 affects Ubiquitination
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2
USP10 affects TGF‐β
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2
USP10 affects Phosphatase
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1
1
USP10 affects Oxidative Stress
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2
USP10 inhibits Oxidative Stress. 2 / 2
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2
USP10 affects NLRP7 protein
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2
USP10 affects LC3B-I
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2
USP10 affects HDAC6 protein
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2
USP10 affects H2A.Zub1
|
2
sparser
"We observed that addition of His6-USP10, but not His6-USP13, reduced the amount of HA-Ub-conjugated FLAG-LC3B ( xref , C and D ), consistent with USP10 specifically catalyzing the deubiquitination of LC3B. Finally, we found that GFP-tagged LC3B (GFP-LC3B) co-immunoprecipitated with FLAG-USP10 but not FLAG-USP13 ( xref E )."
USP10 affects DNA Damage
|
1
USP10 activates DNA Damage. 1 / 2
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1
reach
"We identify 9 direct binding partners of p53 in the nuclear RNA interactome, including USP10, which deubiquitinates and activates p53 in response to DNA damage, and Sumo1, which can itself become covalently coupled to p53 to regulate its activity and subcellular localization (XREF_SUPPLEMENTARY) XREF_BIBR XREF_BIBR XREF_BIBR."
USP10 affects DENV-2 RNA
|
2
USP10 affects CLP-induced oxidative stress renal tissues
|
2
USP10 affects CLP-induced apoptosis renal tissues
|
2
USP10 affects CFTR-DeltaF508
|
2
TOP2α affects RNF168
|
2
reach
"Collectively, these results indicated that BCR and TLR2 synergistically enhance Akt activity and promote USP10 T674 phosphorylation located within the NLS domain and, therefore, the nuclear import of USP10, consequently inhibiting the AID degradation in the nucleus.Pam 3 Csk 4 helped to enhance the antibody response to the SARS-CoV-2 RBD nanoparticle vaccine Pam 3 Csk 4 has been used as a vaccine adjuvant."
reach
"Collectively, these results indicated that BCR and TLR2 synergistically enhance Akt activity and promote USP10 T674 phosphorylation located within the NLS domain and, therefore, the nuclear import of USP10, consequently inhibiting the AID degradation in the nucleus.Pam3Csk4 has been used as a vaccine adjuvant.59 To explore the effect of Pam3Csk4 on the SARS-CoV-2 RBD particle vaccine immune response, USP10-BWT and USP10-BKO mice were immunized with adjuvants in combination with the SARS-CoV-2 RBD particle vaccine."
Particulate Matter affects USP10
2
|
Pam3Csk4 affects USP10
|
2
reach
"To further clarify that anti-μ antibody and Pam3Csk4 co-treatment promoted T674 phosphorylation of USP10, we first generated an antibody that specifically recognizes the phosphorylation site of USP10 by immunizing rabbits with the phosphorylated and sequence-homologous polypeptides (Supplementary Fig. 4a)."
MST1/2 affects USP10
|
2
sparser
"We observed that addition of His6-USP10, but not His6-USP13, reduced the amount of HA-Ub-conjugated FLAG-LC3B ( xref , C and D ), consistent with USP10 specifically catalyzing the deubiquitination of LC3B. Finally, we found that GFP-tagged LC3B (GFP-LC3B) co-immunoprecipitated with FLAG-USP10 but not FLAG-USP13 ( xref E )."
DENV-2 RNA affects USP10
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2
Virulence Cif found patients CF chronic obstructive pulmonary disease affects USP10
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1
Stress granule proteins affects USP10
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1
Spautin -1 affects USP10
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1
Sodium fluoride affects USP10
1
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Small‐molecule inhibitor Spautin‐1 affects USP10
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1
SfRNAs affects USP10
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1
Schizandrin B affects USP10
1
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Pentachlorophenol affects USP10
1
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MiR-103 affects USP10
|
1
Imaging-based screening affects USP10
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1
Hsa-miR-652-3p affects USP10
1
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Hsa-miR-455-3p affects USP10
1
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Geldanamycin affects USP10
1
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Epoxide hydrolase affects USP10
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1
Epoxide hydrolase activates USP10. 1 / 1
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1
Doxycycline affects USP10
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1
Doxycycline activates USP10. 1 / 1
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1
Dicrotophos affects USP10
1
|
reach
"Previous reports had suggested that ATO could degrade FLT3 protein by downregulating USP10 to inhibit FLT3-ITD positive cells, but ATO at low concentrations (0.5 microM) failed to downregulate USP10 and could not induce degradation of total FLT3 and modulation of 160KD or 130KD FLT3 (Additional file 1 : Figure S1A, B)."
VNS affects USP10
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1
USP10 affects ubiquitination reduction
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1
USP10 affects ubiquitination LC3B
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1
USP10 affects stopping cell cycle cancer cell growth
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1
USP10 affects sdRNA
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1
USP10 affects same results
|
1
USP10 affects removal NEMO-attached M1-linked polyubiquitin chains
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1
USP10 affects protein deubiquitination
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1
USP10 activates protein deubiquitination. 1 / 1
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1
eidos
"In the case of DNA damage , the phosphorylation of USP10 at Thr42 and Ser337 mediated by ATM is essential for its translocation to the nucleus , where USP10 induces the deubiquitination of p53 and makes p53 work as a tumor suppressor ( Fig. 2c ) .122 In addition to ubiquitination , p53 can also undergo other ubiquitination-like modifications , such as neddylation and SUMOylation ."
reach
"Compared with AdGFP transfection, AdUSP10 notably alleviated Ang II induced cardiomyocyte enlargement, accompanied by significant decreases in the expression of the fetal genes Anp, Bnp, and Myh7; in contrast, USP10 silencing significantly exacerbated myocyte hypertrophy and upregulated the expression of Anp, Bnp, and Myh7 compared with that in primary cells infected with AdshRNA, suggesting that USP10 can directly mitigate the hypertrophic growth of isolated myocytes induced by Ang II."
USP10 affects lipid uptake
|
1
USP10 affects inflammatory cytokine induction
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1
USP10 affects inflammation response
|
1
USP10 affects imidazolide
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1
USP10 inhibits imidazolide. 1 / 1
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1
USP10 affects hepatic R process
|
1
USP10 affects foam cell cells
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1
USP10 affects extracellular core protein
|
1
USP10 affects dopamine-induced reactive oxygen species-dependent apoptosis neuronal cells
|
1
USP10 affects dopamine-induced Nrf2 translation
|
1
USP10 affects deubiquitination human NHE3 regulating
|
1
USP10 affects cellular senescence
|
1
USP10 activates cellular senescence. 1 / 1
|
1
USP10 affects cell growth invasion lung cancer
|
1
USP10 affects c-KIT
|
1
USP10 affects affecting unknown
|
1
USP10 affects activation NRF2 HO-1 pathway SIRT6
|
1
USP10 affects abundance YAP TAZ
|
1
USP10 affects USP10 inhibitors
|
1
USP10 affects TAK1-JNK p38 Activation Hepatic R Injury MAPKs play mediating inflammatory response cell death
|
1
USP10 affects Quercetin.USP10
|
1
USP10 affects Parkinson
|
1
USP10 affects NSCLC
|
1
USP10 affects NASH
|
1
USP10 affects K63-linked polyubiquitination mediated TRIM25 non-small cell lung cancer
|
1
USP10 affects ITD [42]
|
1
USP10 affects GR
|
1
USP10 affects Endometriosis
|
1
USP10 activates Endometriosis. 1 / 1
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1
USP10 affects Carcinoma, Hepatocellular
|
1
USP10 activates Carcinoma, Hepatocellular. 1 / 1
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1
USP10 affects CCND3/CDK4/6
|
1
USP10 affects Bcr-Abl
|
1
USP10 affects AngII-induced Akt
|
1
eidos
"USP10 Directly Regulates Sirt6 During Cardiac Hypertrophy To delineate the mechanisms by which USP10 expression modulates AngII-induced Akt activation , we investigated whether USP10 affect the stability of Sirt6 , which has been shown to block insulin-like growth factor-Akt signaling and the development of CH ."
USP10 affects ARF
|
1
Spain-1 affects USP10
|
1
Sesame Oil affects USP10
1
|
Niclosamide affects USP10
1
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N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases the amount of USP10. 1 / 1
|
1
L-methionine affects USP10
1
|
reach
"One of the first evidences of the participation of RNA modifications in the dynamics of SGs was the observation that m A disrupts RNA binding by G3BP1/2, ubiquitin-specific peptidase 10 (USP10), cell cycle-associated protein 1 (CAPRIN1), and RNA-binding motif protein 42 (RBM42), all proteins of SGs (Arguello et al., 2017; Edupuganti et al., 2017)."