IndraLab

Statements

STAM affects STAMBP
19 2 | 36 44
STAM binds STAMBP.
19 2 | 25 39
STAM binds STAMBP. 10 / 73
19 2 | 20 27
sparser
"Based on the NMR structure of AMSH and STAM complex (PDB ID: 5IXF) from H. sapiens , Hologne et al. considered that the interaction of AMSH-SBM and STAM-SH3 contributed to the correct positioning of polyubiquitin chains toward AMSH before cleavage [ xref , xref ]."
35883466
reach
"Recent studies have shown that the presence of STAM increases the efficiency of Lys63-linked polyubiquitin chain cleavage by AMSH, which binds STAM through its SBM."
27725184
sparser
"Thus, the STAM-AMSH complex can bind up to three ubiquitin molecules ( xref )."
40157538
sparser
"A further link to receptor signaling is provided by AMSH ( a ssociated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11911875
biogrid
No evidence text available
16431367
biogrid
No evidence text available
16431367
reach
"We have confirmed a previously reported interaction between AMSH and STAM, a protein which is in dynamic equilibrium between cytosol and endosomal membranes."
15314065
sparser
"The observations that STAM interacts with AMSH ( xref ; xref ), a DUB specifically involved in K63Ub chain disassembly ( xref ), and that ubiquitylated forms of both STAM and Hrs accumulate in AMSH −/− cells ( xref ; xref ) suggest that ESCRT proteins may also be modified by K63Ub chains in mammals."
22493318
sparser
"A good example is the association of AMSH with STAM, which can serve to couple enzyme activity to its endosomal localization."
16996268
sparser
"Additionally, our biochemical data show that STAM1 binding to STAMBP facilitates substrate binding and enhances its activity, whereas binding of CHMP3 does not relieve autoinhibition or enhance activity."
40441142
STAMBP binds USP8 and STAM. 5 / 5
| 5
sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
26918171
STAMBP binds STAM and GRB2. 3 / 3
| 3
sparser
"The RXXK motif of AMSH interacts with the SH3 domains of the STAM and Grb2 families of adaptor proteins with high affinity."
20159979
sparser
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12–14] , we speculate that the neuronal cell death in the AMSH-deficient brain might be caused by the lack of interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"Whereas AMSH bound to both STAM1 and Grb2 ( Figs."
12810066
STAMBP binds STAM and SH3 domain. 3 / 3
| 3
reach
"To probe this, we used a combination of biophysical techniques and biochemical assays to assess three individual events : (1) AMSH recruitment to STAM via the SH3 domain and a longer STAM segment in which the UIM is fused to the SH3 domain (UIM-SH3), (2) ubiquitin binding to UIM-SH3, and finally, (3) the ternary complex of the catalytic domain of AMSH, UIM-SH3, and Lys63 linked diubiquitin."
24151880
reach
"We determined that the SH3 domain of STAM binds the catalytic domain of AMSH (AMSH219 E280A) with a K D of 1.4 +/- 0.04 microM (XREF_TABLE and XREF_SUPPLEMENTARY)."
24151880
reach
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner."
16702236
STAM binds STAMBP and Lys63. 1 / 1
| 1
reach
"Interestingly, the binding of STAM with AMSH increases its activity toward Lys63-linked polyubiquitin chains [5,23] ."
27725184
STAMBP binds STAM and snf7. 1 / 1
| 1
sparser
"Recent studies showed that AMSH binds to the ESCRT-III complex in a STAM-independent manner ( xref ; xref ), in support of the suggestion that AMSH might be a counterpart of Doa4p ( xref )."
17660439
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
STAMBP binds STAM and MVP. 1 / 1
| 1
sparser
"We wondered whether AMSH can interact simultaneously with STAM and mVps24."
16431367
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
STAM binds HGS and STAMBP. 1 / 1
| 1
reach
"Thus, the STAM, Hrs, and AMSH complex may engage in a tripartite interaction with clathrin, embedding it within the endosomal coat structure.Hrs serves to recruit downstream components of the MVB sort[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
STAM activates STAMBP.
| 6 5
STAM activates STAMBP. 10 / 12
| 6 5
sparser
"In addition, we observed inhibition of STAM1-activated full-length STAMBP by both UbV SP."
34425109
sparser
"As can be seen, the foundation of the AMSH activation by STAM has been explored by means of different biological assays."
27725184
sparser
"In the current article, we aspire to understand if any particular structural organization forms a basis for the activation of AMSH by STAM and allows a better efficiency of its enzymatic process towar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
sparser
"While either deletion or mutation of the STAM-UIM or -SH3 domain prevents the activation of AMSH by STAM (see Fig. 1 a for structural details) [25] , we were seeking to understand if and how Lys63-Ub [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
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"It has been reported that pre-incubation with STAM stimulates AMSH 's DUB activity on tetra-Ubs, which supports our data strongly [25]."
17078930
reach
"In the current article, we aspire to understand if any particular structural organization forms a basis for the activation of AMSH by STAM and allows a better efficiency of its enzymatic process towar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
reach
"We propose a possible organization where the plasticity of STAM2, combined with the flexibility of AMSH, allows its possible interaction with Lys63-linked polyubiquitin chains and induces further chai[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
reach
"As can be seen, the foundation of the AMSH activation by STAM has been explored by means of different biological assays."
27725184
reach
"We propose that STAM fulfills an adaptor function for AMSH and that there might be a correspondingly diverse set of DUB and adaptor combinations.The ability of STAM to directly stimulate AMSH activity[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
STAM inhibits STAMBP.
| 5
STAM inhibits STAMBP. 5 / 5
| 5
reach
"In addition, we observed inhibition of STAM1-activated full-length STAMBP by both UbV SP.1 and UbV SP.3 in this chain cleavage assay (Fig. S2C) ."
| DOI
reach
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
reach
"In addition, we observed inhibition of STAM1-activated full-length STAMBP by both UbV and UbV in this chain cleavage assay (Fig. S2C)."
34425109
reach
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of fulllength STAMBP activated by STAM protein and full-length STAMBPL1."
| DOI
reach
"Moreover, removal or mutations of either the STAM UIM or SH3 domain reduce the AMSH catalytic activity toward Lys63-Ub 2 chains [23–25] ."
27725184
STAMBP affects STAM
19 2 | 28 39
STAMBP binds STAM.
19 2 | 25 39
STAM binds STAMBP. 10 / 73
19 2 | 20 27
sparser
"Based on the NMR structure of AMSH and STAM complex (PDB ID: 5IXF) from H. sapiens , Hologne et al. considered that the interaction of AMSH-SBM and STAM-SH3 contributed to the correct positioning of polyubiquitin chains toward AMSH before cleavage [ xref , xref ]."
35883466
reach
"Recent studies have shown that the presence of STAM increases the efficiency of Lys63-linked polyubiquitin chain cleavage by AMSH, which binds STAM through its SBM."
27725184
sparser
"Thus, the STAM-AMSH complex can bind up to three ubiquitin molecules ( xref )."
40157538
sparser
"A further link to receptor signaling is provided by AMSH ( a ssociated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11911875
biogrid
No evidence text available
16431367
biogrid
No evidence text available
16431367
reach
"We have confirmed a previously reported interaction between AMSH and STAM, a protein which is in dynamic equilibrium between cytosol and endosomal membranes."
15314065
sparser
"The observations that STAM interacts with AMSH ( xref ; xref ), a DUB specifically involved in K63Ub chain disassembly ( xref ), and that ubiquitylated forms of both STAM and Hrs accumulate in AMSH −/− cells ( xref ; xref ) suggest that ESCRT proteins may also be modified by K63Ub chains in mammals."
22493318
sparser
"A good example is the association of AMSH with STAM, which can serve to couple enzyme activity to its endosomal localization."
16996268
sparser
"Additionally, our biochemical data show that STAM1 binding to STAMBP facilitates substrate binding and enhances its activity, whereas binding of CHMP3 does not relieve autoinhibition or enhance activity."
40441142
STAMBP binds USP8 and STAM. 5 / 5
| 5
sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
26918171
STAMBP binds STAM and GRB2. 3 / 3
| 3
sparser
"The RXXK motif of AMSH interacts with the SH3 domains of the STAM and Grb2 families of adaptor proteins with high affinity."
20159979
sparser
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12–14] , we speculate that the neuronal cell death in the AMSH-deficient brain might be caused by the lack of interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"Whereas AMSH bound to both STAM1 and Grb2 ( Figs."
12810066
STAMBP binds STAM and SH3 domain. 3 / 3
| 3
reach
"To probe this, we used a combination of biophysical techniques and biochemical assays to assess three individual events : (1) AMSH recruitment to STAM via the SH3 domain and a longer STAM segment in which the UIM is fused to the SH3 domain (UIM-SH3), (2) ubiquitin binding to UIM-SH3, and finally, (3) the ternary complex of the catalytic domain of AMSH, UIM-SH3, and Lys63 linked diubiquitin."
24151880
reach
"We determined that the SH3 domain of STAM binds the catalytic domain of AMSH (AMSH219 E280A) with a K D of 1.4 +/- 0.04 microM (XREF_TABLE and XREF_SUPPLEMENTARY)."
24151880
reach
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner."
16702236
STAM binds STAMBP and Lys63. 1 / 1
| 1
reach
"Interestingly, the binding of STAM with AMSH increases its activity toward Lys63-linked polyubiquitin chains [5,23] ."
27725184
STAMBP binds STAM and snf7. 1 / 1
| 1
sparser
"Recent studies showed that AMSH binds to the ESCRT-III complex in a STAM-independent manner ( xref ; xref ), in support of the suggestion that AMSH might be a counterpart of Doa4p ( xref )."
17660439
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
STAMBP binds STAM and MVP. 1 / 1
| 1
sparser
"We wondered whether AMSH can interact simultaneously with STAM and mVps24."
16431367
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
STAM binds HGS and STAMBP. 1 / 1
| 1
reach
"Thus, the STAM, Hrs, and AMSH complex may engage in a tripartite interaction with clathrin, embedding it within the endosomal coat structure.Hrs serves to recruit downstream components of the MVB sort[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
STAMBP activates STAM.
| 2
STAMBP activates STAM. 2 / 4
| 2
reach
"Further, the DUB activity of STAMBP modulates the ubiquitination of ESCRT proteins STAM and hepatocyte growth factor regulated tyrosine kinase substrate (HRS), but does not affect their degradation or stability XREF_BIBR XREF_BIBR."
28492230
reach
"The gene encoding AMSH (associated molecule with a Src homology 3 domain), a deubiquitinating enzyme, was up-regulated as well as, three genes involved in the ESCRT pathway, ESCRT-0 (STAM (signal transducing adaptor molecule)) and ESCRT-III (CHMP (charged multivesicular body proteins) 2 and 4)."
29023475
STAMBP ubiquitinates STAM.
| 1
Modified STAMBP leads to the ubiquitination of STAM. 1 / 1
| 1
reach
"Depletion of AMSH by siRNA does not affect CXCR4 degradation, but expression of AMSH dominant negative constructs enhances HRS or STAM ubiquitination and inhibits CXCR4 degradation."
24790097
CHMP3 affects STAMBP
23 2 | 21 27
CHMP3 binds STAMBP.
23 2 | 20 27
STAMBP binds CHMP3. 10 / 73
23 2 | 19 24
sparser
"We show that AMSH binds to CHMP3 in 0 HBS (closed conformation) and 500 HBS (open conformation) with dissociation constants of 5.6 and 392 nM, respectively, implying that the closed conformer binds [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18395747
sparser
"However, there are two reasons why the CHMP3–AMSH interaction may induce CHMP3 opening as suggested."
18395747
sparser
"The high-affinity CHMP3–AMSH interaction may explain why AMSH overexpression renders full-length CHMP3 dominant negative with respect to HIV-1 budding, 9 because it may sequester CHMP3 in a state tha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18395747
sparser
"Because CHMP3 within a functional ESCRT-III complex seems to act late in budding, the presence of a high-affinity CHMP3–AMSH interaction would ensure efficient deubiquitination before budding is compl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18395747
sparser
"The ~ 60 nM K d for the CHMP3-AMSH interaction is to date the highest K d reported for an ESCRT-III MIM-MIT interaction."
21827950
sparser
"In principle, CHMP3 could interact with Vps4 via a similar region; this, however, raises the question as to how a high-affinity CHMP3–AMSH interaction switches to a low-affinity CHMP3–Vps4 interacti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18395747
sparser
"Interaction constants characterizing the AMSH and CHMP3 protein–peptide interaction were determined by direct titration in 0 HBS, 150 HBS, and 500 HBS at 25 °C. The concentrations used are summariz[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18395747
sparser
"The high affinity interaction between CHMP3 and AMSH is mainly mediated by 6 salt bridges along the CHMP3 helix compared to 2 salt bridges in case of the spastin-MIT-CHMP1B interaction."
21827950
reach
"Collectively data from these three different interaction studies provide strong evidence that the predicted interactions between CHMP1B and AMSH, CHMP3 and AMSH, and CHMP2A and LOC129531 may well be p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
reach
"Although CHMP3 binds with high affinity to AMSH, ESCRT-III CHMP1A and B show only micromolar interactions."
21827950
STAMBP binds CHMP3 and VPS4A. 2 / 2
| 2
sparser
"The MIM 1 sequence motif responsible for VPS4 interaction [ xref ] overlaps with the CHMP3-AMSH binding site and superpositioning of the VPS4A-CHMP1B and VPS4B-CHMP2A structures with AMSH-CHMP3 demonstrates the overlap of the binding motifs, which prohibits simultaneous binding of AMSH and VPS4 to CHMP3."
21827950
sparser
"Furthermore the AMSH binding site overlaps with the VPS4 site on CHMP3 ( xref ) [ xref , xref ], consistent with the finding that AMSH CHMP3 and VPS4 binding are exclusive (data not shown)."
21827950
STAMBP binds CHMP3 and MIT domain. 1 / 1
| 1
reach
"This suggests that the AMSH MIT domain interaction with CHMP3 differs substantially from the low-affinity Vps4 MIT domain interaction."
18395747
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP3 activates STAMBP.
| 1
CHMP3 activates STAMBP. 1 / 2
| 1
reach
"In contrast a dominant negative form of CHMP3 prevents AMSH localization to the endosome, which in turn inhibits EGFR degradation [XREF_BIBR]."
21827950
STAMBP affects EGFR
12 1 1 | 30 2
STAMBP deubiquitinates EGFR.
12 1 | 8
STAMBP deubiquitinates EGFR. 9 / 9
1 | 8
reach
"AMSH can deubiquitinate EGFR and prompt recycling to the plasma membrane [XREF_BIBR], whilst USP8 is required for the degradation of EGFR in the lysosome [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25026282
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"In support of this notion, we are able to show that EGFR, immunoprecipitated from EGF stimulated Her14 cells, can be deubiquitinated by AMSH in vitro."
15314065
reach
"13 This implies that AMSH is able to completely deubiquitinate EGFR, since monoubiquitinated EGFR can still be targeted to lysosome."
21888914
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"STAMBP may deubiquitinate EGFR by localizing in early endosomes and increase EGFR membrane localization in LUAD cells."
34102455
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"AMSH can deubiquitinate EGFR that has been immunoprecipitated from EGF-stimulated cells [31,37] ."
16996268
ubibrowser
"<span class="match term0">STAMBP</span> may deubiquitinate <span class="match term1">EGFR</span> by localizing in early endosomes and increase EGFR membrane localization in LUAD cells."
34102455
reach
"AMSH modulates the deubiquitination of the EGF receptor, thereby inhibiting its inclusion in the luminal vesicles of endosomes and instead promoting its recycling to the plasma membrane [249,250] ."
26855059
reach
"AMSH was shown to deubiquitylate in vitro EGFR immunoprecipitated from EGF stimulated cells [XREF_BIBR], and siRNA knockdown of AMSH resulted in accelerated EGFR degradation in HeLa cells, which suggests that AMSH dependent deubiquitylation of EGFR counteracts Cbl dependent ubiquitylation of the receptor [XREF_BIBR]."
25396681
reach
"Besides, STAMBP can deubiquitinate epidermal growth factor receptor (EGFR) and trigger mitogen-activated protein kinase signaling by increasing EGFR stability to promote lung adenocarcinoma metastasis [36]."
40180620
STAMBP deubiquitinates EGFR phosphorylated on Y1016, K754, K716, Y1197, K970, K929, K867, Y1172, Y1110, Y1092, and Y1069 on K737. 2 / 2
2 |
biopax:pid
No evidence text available
17052190
biopax:pid
No evidence text available
15314065
STAMBP deubiquitinates EGFR phosphorylated on Y1016, K754, K737, Y1197, K970, K929, K867, Y1172, Y1110, Y1092, and Y1069 on K716. 2 / 2
2 |
biopax:pid
No evidence text available
17052190
biopax:pid
No evidence text available
15314065
STAMBP deubiquitinates EGFR phosphorylated on Y1016, K737, K716, Y1197, K970, K929, K867, Y1172, Y1110, Y1092, and Y1069 on K754. 2 / 2
2 |
biopax:pid
No evidence text available
17052190
biopax:pid
No evidence text available
15314065
STAMBP deubiquitinates EGFR phosphorylated on Y1016, K754, K737, K716, Y1197, K970, K867, Y1172, Y1110, Y1092, and Y1069 on K929. 2 / 2
2 |
biopax:pid
No evidence text available
17052190
biopax:pid
No evidence text available
15314065
STAMBP deubiquitinates EGFR phosphorylated on Y1016, K754, K737, K716, Y1197, K929, K867, Y1172, Y1110, Y1092, and Y1069 on K970. 2 / 2
2 |
biopax:pid
No evidence text available
17052190
biopax:pid
No evidence text available
15314065
STAMBP deubiquitinates EGFR phosphorylated on Y1016, K754, K737, K716, Y1197, K970, K929, Y1172, Y1110, Y1092, and Y1069 on K867. 2 / 2
2 |
biopax:pid
No evidence text available
15314065
biopax:pid
No evidence text available
17052190
STAMBP activates EGFR.
| 13
STAMBP activates EGFR. 10 / 15
| 13
reach
"STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR and MAPK signaling pathway."
34102455
reach
"In other studies, both AMSH XREF_BIBR, XREF_BIBR and UBPY XREF_BIBR, XREF_BIBR, XREF_BIBR have been reported to increase EGFR down-regulation."
22710717
reach
"Mechanistically, increased STAMBP expression promoted the stabilization of Epidermal growth factor receptor (EGFR), whereas STAMBP knockdown induced the degradation of EGFR."
34102455
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"However, other studies have shown that BC-1471 exerted no inhibitory effect on STAMBP-mediated ubiquitination deconjugation or STAMBP-mediated EGFR stabilization in vitro ."
36434041
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"Importantly, increased STAMBP promoted the stabilization of EGFR, suggesting STAMBP as a novel target for LUAD therapy [168]."
36694209
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"Its homologue STAMBP (or AMSH) is known to participate in endosomal sorting of receptors and membrane proteins [XREF_BIBR], e.g., STAMBP knockdown enhancing EGFR degradation."
30018743
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"13 Although AMSH depletion does not impair epidermal growth factor receptor degradation, 14,15 inhibition of its recruitment to endosomes by ESCRT-III charged MVB protein (CHMP) 3 impairs epidermal gr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18395747
reach
"[1617] Remarkably, a second Hrs interacting protein is AMSH, a JAMM domain DUB,[18] the inhibition of which results in the accumulation of endosomal Ub and promotes EGFR endocytosis, thereby accelerating EGFR downregulation."
40061651
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"Nevertheless, both AMSH [31, 34, 35] and UBPY [32, 33, 36-38] have been reported to increase EGFR down-regulation."
29981430
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"AMSH rescues EGFR from sorting to MVBs and consequently degradation, by removing Ub from the receptor at early stages of endosomal sorting, thus promoting its recycling [64,67,68] ."
19007773
STAMBP inhibits EGFR.
| 6
STAMBP inhibits EGFR. 6 / 9
| 6
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"Depletion of AMSH, which alters the balance of E3 ligase and DUB activity in the endosomal system, enhances the degradation of EGFR, presumably by inhibiting the removal of ubiquitin from EGFR and thereby preventing its ability to recycle."
24456136
reach
"In contrast, EGF-R internalization is inhibited by AMSH protein."
16925951
reach
"Based on siRNA-depletion experiments, AMSH is proposed to negatively regulate EGFR downregulation and consequently to enhance recycling of the receptor ( Bowers et al., 2006 ; McCullough et al., 2004 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22975321
reach
"Inhibition of AMSH accelerates EGFR down-regulation suggesting a role in antagonizing ubiquitin dependent sorting of cargo to the lysosome."
19489724
reach
"Conversely, AMSH negatively regulates EGFR down-regulation and is proposed to recycle the EGFR at the sorting endosome."
16702236
reach
"Short interfering RNA (siRNA) knockdown of AMSH accelerates EGFR down-regulation."
15314065
STAMBP ubiquitinates EGFR.
| 3
Modified STAMBP-D348A leads to the ubiquitination of EGFR. 2 / 2
| 2
reach
"As expected, EGF stimulation of serum starved cells resulted in ubiquitination of the EGFR, while co-expression of AMSH D348A significantly increased EGFR ubiquitination."
23153581
reach
"As expected, EGF stimulation of serum starved cells resulted in ubiquitination of the EGFR, while co-expression of AMSH D348A significantly increased EGFR ubiquitination."
22800866
STAMBP leads to the ubiquitination of EGFR. 1 / 1
| 1
reach
"Some studies showed that AMSH [31] and UBPY [32, 33] prevent EGFR down-regulation by deubiquitinating EGFR."
29981430
STAMBP binds EGFR.
1 | 2
STAMBP binds EGFR. 3 / 3
1 | 2
sparser
"Our data also indicate a functionally significant association of AMSH with endosomes that influences the rate of EGF receptor (EGFR) degradation."
15314065
biogrid
No evidence text available
34102455
sparser
"To provide mechanical insight into STAMBP-mediated EGFR protein stabilization in LUAD cells, we assessed whether STAMBP can bind directly to EGFR."
34102455
P2 affects STAMBP
| 28
P2 binds STAMBP. 10 / 28
| 28
sparser
"The backbone and side-chain resonance assignments of UIM-SH3 bound to AMSH-P2 have been deposited to the BMRB under the accession number 30041."
27725184
sparser
"The backbone resonance assignment of the UIM-SH3 construct in the free state has been obtained previously [24] , while the backbone assignment of UIM-SH3 in complex with AMSH-P2 has been obtained by m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"Intermolecular NOEs between aliphatic/aromatic protons of UIM-SH3 and AMSH-P2 were obtained from 3D NOESY-HSQC (mixing time equal to 200 ms) and ( 15 N, 13 C)-filtered, 13 C-edited 3D NOESY-HSQC (mixi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"In the case of the 15 N-UIM-SH3/AMSH-P2 complex or the 15 N-UIM-SH3 + AMSH-P2 + Lys63-Ub 2 complex, we used transverse relaxation periods of 10, 30, 50, 70 (twice), 90, 130, 170 (twice), 210, and 230 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"The whole AMSH-P2 peptide has been defined as fully flexible."
27725184
sparser
"For AMSH-P2, the average pattern of CSPs did not exhibit any drastic change except for Tyr218, Asp219, and Ala244 ( Fig. 2 b)."
27725184
sparser
"Additionally, the peptides containing half of the AMSH-P2 sequence (AMSH-P5 and P6) did not exhibit any significant CSPs and hence no significant binding with SH3 (see Fig. S12A and B)."
27725184
sparser
"From the titration curves (Fig. S14B), we derived a dissociation constant of 563 ± 120.0 μM that is practically 200-fold greater compared to the binding of AMSH-P2 with SH3."
27725184
sparser
"To address this question, we used the AMSH-P2 peptide and analyzed the CSPs of the UIM-SH3/Lys63-Ub 2 complex in the presence of AMSH-P2."
27725184
sparser
"To an 15 N-UIM-SH3 sample saturated by Lys63-Ub 2 , we gradually added AMSH-P2 and monitored the CSPs in the corresponding 1 H, 15 N-HSQC spectrum."
27725184
BMPR1B affects STAMBP
10 16 |
BMPR1B phosphorylates STAMBP.
5 15 |
BMPR1B phosphorylates STAMBP on S245. 4 / 4
1 3 |
hprd
No evidence text available
11483516
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
hprd
No evidence text available
11483516
hprd
No evidence text available
11483516
BMPR1B phosphorylates STAMBP on S2. 4 / 4
1 3 |
hprd
No evidence text available
11483516
hprd
No evidence text available
11483516
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
hprd
No evidence text available
11483516
BMPR1B phosphorylates STAMBP on S247. 4 / 4
1 3 |
hprd
No evidence text available
11483516
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
hprd
No evidence text available
11483516
hprd
No evidence text available
11483516
BMPR1B phosphorylates STAMBP on S48. 4 / 4
1 3 |
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
hprd
No evidence text available
11483516
hprd
No evidence text available
11483516
hprd
No evidence text available
11483516
BMPR1B phosphorylates STAMBP on S243. 4 / 4
1 3 |
hprd
No evidence text available
11483516
hprd
No evidence text available
11483516
hprd
No evidence text available
11483516
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
BMPR1B activates STAMBP.
5 |
BMPR1B activates STAMBP. 5 / 5
5 |
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
BMPR1B binds STAMBP.
1 |
BMPR1B binds STAMBP. 1 / 1
1 |
hprd
No evidence text available
11483516
STAMBP affects NLRP7
1 | 1 21 1
STAMBP deubiquitinates NLRP7.
| 9
STAMBP deubiquitinates NLRP7. 9 / 9
| 9
reach
"Moreover, complex post-translational modifications regulate its activity; namely, NLRP7 is either ubiquitinated to regulate its functions, or deubiquitinated by the STAM-binding protein to prevent its trafficking to lysosomes and its degradation [59]."
37443800
reach
"We next tested inhibition of STAMBP DUB activity specific to Ub-NALP7; here inclusion of BC-1471 blocked STAMBP mediated deubiquitination of Ub-NALP7 in vitro in a concentration dependent manner (XREF_FIG), where BC-1471 performed comparably to the broad-spectrum metalloprotease DUB inhibitor 1,10-phenanthroline."
28492230
reach
"STAMBP is sufficient to deubiquitinate NALP7 and is necessary to stabilize NALP7 protein in cells exposed to LPS or Pam3CSK4."
28492230
reach
"Bednash et al. 75 showed that the DUB STAMPBP (or AMSH) deubiquitinates NLRP7 rescuing this receptor from progressing to lysosome degradation and making it available for the formation of an active inflammasome."
31679183
reach
"STAMBP promotes inflammasome activity in innate immune responses by mediating the deubiquitination of NALP7 and preventing the transport of NALP7 to lysosomes, thereby increasing NALP7 abundance ."
36434041
reach
"BC-1471 (43) was discovered as a specific STAMBP inhibitor (IC 50 = 0.33 muM) that selectively blocked deubiquitination of Ub-NALP7 by recombinant STAMBP [XREF_BIBR] but did not significantly inhibit the activity of a panel of 38 different DUBs at the concentration tested."
32196552
reach
"Our findings suggest that STAMBP (STAM binding protein), which deubiquitinates NALP7 and increases its abundance by preventing lysosomal trafficking, may promote inflammatory factors ."
39774240
reach
"Since STAMBP is known to function as a DUB, we developed a cell-free DUB assay to test STAMBP deubiquitination of NALP7."
28492230
reach
"This finding supports that STAMBP is sufficient to directly deubiquitinate NALP7."
28492230
STAMBP activates NLRP7.
| 1 4
STAMBP activates NLRP7. 5 / 5
| 1 4
reach
"We hypothesized that targeting of STAMBP DUB activity to destabilize NALP7 will decrease NALP7 inflammasome activity, namely secretion of mature IL-1beta."
28492230
reach
"Our findings that NALP7 abundance is modulated by the ESCRT-0 complex protein STAM and the DUB STAMBP suggest that NALP7 may similarly function at the early endosome and that, furthermore, NALP7 is processed through the endosomal pathway to the lysosome for degradation."
28492230
reach
"These results are consistent with prior data demonstrating NALP7 degradation at the lysosome and STAMBP rescue of NALP7."
28492230
reach
"STAMBP may increase NALP7 (NACHT, LRR and PYD domains-containing protein 7) abundance by inhibiting the trafficking of the inflammasome NALP7 to lysosomes and preventing the lysosomal degradation of NALP7 (Bednash et al., 2017)."
37293545
eidos
"Our group previously demonstrated a functional relationship between STAMBP and another inflammasome protein NLRP7 , whereby STAMBP knockdown enhanced NLRP7 degradation and decreased IL-1beta release in differentiated THP-1 macrophages ( 20 ) ."
33253913
STAMBP increases the amount of NLRP7.
| 4
STAMBP increases the amount of NLRP7. 4 / 4
| 4
reach
"The new findings of this study are that (i) NALP7 is a ubiquitinated protein degraded within the lysosome, (ii) LPS and Pam3CSK4 preserve NALP7 protein by disrupting lysosomal trafficking, (iii) NALP7 abundance is modulated by the DUB, STAMBP and (iv) pharmacologic targeting of STAMBP deubiquitinase activity using a novel chemical entity abrogates induction of NALP7 levels in response to these PAMPs, thereby significantly suppressing IL-1beta secretion."
28492230
reach
"In the current study, STAMBP silencing decreases NALP7 levels constitutively, but has a more robust effect when cells are exposed to TLR agonists as a stimulus."
28492230
reach
"STAMBP increases NLRP7 protein levels by impairing its trafficking to lysosomes."
35800898
reach
"A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1beta release after TLR agonism."
28492230
STAMBP inhibits NLRP7.
| 3
STAMBP inhibits NLRP7. 3 / 3
| 3
reach
"STAMBP may increase NALP7 (NACHT, LRR and PYD domains-containing protein 7) abundance by inhibiting the trafficking of the inflammasome NALP7 to lysosomes and preventing the lysosomal degradation of NALP7 (Bednash et al., 2017)."
37293545
reach
"With TLR ligation, the deubiquitinase enzyme, STAM binding protein (STAMBP) impedes NALP7 trafficking to lysosomes to increase NALP7 abundance."
28492230
reach
"The first evidence between NLRP7 and ubiquitin pathway was published in 2017, where Bednash and colleagues described that the DUB STAM-binding protein (STAMBP) was able to inhibit NLRP7 activity through deubiquitylation of poly-ubiquitin chains conjugated to Lys288 and Lys290 residues (Bednash et al., 2017)."
35800898
STAMBP binds NLRP7.
1 | 1
NLRP7 binds Ubiquitin and STAMBP. 1 / 1
| 1
sparser
"Further, we introduce the small molecule BC-1471, which interrupts STAMBP-Ub-NALP7 interaction and suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, peripheral blood mononuclear cells and lung organ culture."
28492230
STAMBP binds NLRP7. 1 / 1
1 |
biogrid
No evidence text available
28492230
STAMBP decreases the amount of NLRP7.
| 1
STAMBP decreases the amount of NLRP7. 1 / 1
| 1
reach
"BC-1471 is a small-molecule inhibitor against the catalytic activity of STAMBP, which may reduce the level of its substrate NALP7 protein in THP-1 cells ."
36434041
STAMBP affects Ubiquitin
| 8 8 1
STAMBP binds Ubiquitin.
| 1 8 1
Ubiquitin binds STAMBP. 6 / 8
| 1 5
sparser
"To develop potent and specific inhibitors for STAMBP, we decided to employ a structure-based combinatorial Ub engineering strategy to inhibit the Ub-STAMBP protein–protein interaction ( xref ) selectively."
34425109
sparser
"Using the STAMBP crystal structure xref (3RZU.pdb) and the structure of the nearly identical DUB domain of STAMBPL1 in complex with a di-Ub chain (2ZNV.pdb xref ), we used in silico molecular modelling to simulate the interaction between STAMBP and Ub ( xref )."
28492230
sparser
"Because the crystal structure of AMSH bound to ubiquitin is not known, we took advantage of our structure to gain insights into possible effects the mutation may have on the structure of AMSH and its ubiquitin recognition. xref "
24787148
sparser
"AMSH-LP has no functional SBM or MIT (microtubule interacting and transport) domain, and therefore cannot bind to other components of the ESCRT machinery, but a host of experimental studies have shown that the STAM protein connected to AMSH in a more subtle manner and serves as an activator of this enzymatic process [ xref , xref ], with the UIM domain of STAM serving as an activator in interactions with the proximal Ub of Lys63-Ub 2 and AMSH interacting with the distal Ub."
25396681
reach
"pdb) and the structure of the nearly identical DUB domain of STAMBPL1 in complex with a di-Ub chain, we used in silico molecular modelling to simulate the interaction between STAMBP and Ub (XREF_SUPPLEMENTARY)."
28492230
sparser
"Biophysical characterization of ubiquitin binding to the catalytic domain of AMSH."
24151880
STAMBP binds RIPK2 and Ubiquitin. 1 / 1
| 1
sparser
"Next we purified ubiquitin conjugates from L18-MDP-stimulated Mysm1 − /− BMDMs by TUBE and incubated them with recombinant MYSM1 (Rec-MYSM1) and compared the ubiquitin restriction pattern of Ub-RIP2 with that of AMSH, UCHL3, OTULIN or a combination of these three DUBs (Fig.  xref )."
30405132
NLRP7 binds Ubiquitin and STAMBP. 1 / 1
| 1
sparser
"Further, we introduce the small molecule BC-1471, which interrupts STAMBP-Ub-NALP7 interaction and suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, peripheral blood mononuclear cells and lung organ culture."
28492230
STAMBP binds K63 and Ubiquitin. 1 / 1
| 1
sparser
"This is best illustrated by the structure obtained for a catalytically inactive variant of AMSH bound to K63-linked Ub dimer ( xref )."
22196026
Ubiquitin binds STAMBP. 1 / 1
| 1
isi
"By downregulating candidate deubiquitinases that are either linked with GPCR trafficking or localized on endosomes, we identified signal-transducing adaptor molecule binding protein (STAMBP) and ubiquitin specific protease 33 (USP33) as cognate deubiquitinases for the GCGR."
32967969
STAMBP inhibits Ubiquitin.
| 3
STAMBP inhibits Ubiquitin. 2 / 3
| 2
reach
"Immunoblot analysis revealed that ubiquitin chains were completely degraded by AMSH but neither by OTUB1 nor the GST control, further supporting our finding that TRIAD3 synthesises K63 linked ubiquitin chains in vitro, full length TRIAD3 protein as well as the TRIAD3-RBR 845 fragment."
30886743
reach
"Depletion of AMSH, which alters the balance of E3 ligase and DUB activity in the endosomal system, enhances the degradation of EGFR, presumably by inhibiting the removal of ubiquitin from EGFR and thereby preventing its ability to recycle."
24456136
Mutated STAMBP inhibits Ubiquitin. 1 / 1
| 1
reach
"In cells, a dominant negative AMSH mutant caused an accumulation of ubiquitin at endosomes."
| PMC
STAMBP activates Ubiquitin.
| 4
STAMBP activates Ubiquitin. 4 / 4
| 4
reach
"For the AMSH treatment, substrates were modified with 400 muM wild-type ubiquitin, then treated with 20 muM AMSH for 30 minutes at RT before analysis by SDS-PAGE and visualization by 5-FAM fluorescence on a ChemiDoc (Bio-Rad)."
30929903
reach
"AMSH rescues EGFR from sorting to MVBs and consequently degradation, by removing Ub from the receptor at early stages of endosomal sorting, thus promoting its recycling [64,67,68] ."
19007773
reach
"Similarly, endosomal deubiquitinase AMSH (Associated Molecule with the SH3-domain of STAM) has been shown to antagonize the ubiquitin dependent lysosomal degradation of EGFR by trimming the K63 linked ubiquitin chains [XREF_BIBR] while other studies have shown this DUB to be required for MVB dependent EGFR degradation [XREF_BIBR, XREF_BIBR]."
23085373
reach
"71 In contrast to PAR2, USP8 (or AMSH) does not impact CXCR4 ubiquitination but instead modulates the ubiquitin status of ESCRT-0 that is ubiquitinated by the E3 ligase AIP4, 23 reinforcing the idea that ubiquitination of the transport machinery represents an important regulatory event in GPCR trafficking."
26055053
STAMBP affects GRB2
12 1 | 2 4
STAMBP binds GRB2.
12 1 | 1 4
STAMBP binds GRB2. 10 / 16
12 1 | 1 1
biogrid
No evidence text available
25416956
reach
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12-14], we speculate that the neuronal cell death in the AMSH deficient brain might be caused by the lack of interaction [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
biogrid
No evidence text available
12810066
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
20159979
biogrid
No evidence text available
21706016
biogrid
No evidence text available
20159979
hprd
No evidence text available
16730941
biogrid
No evidence text available
20159979
STAMBP binds STAM and GRB2. 3 / 3
| 3
sparser
"The RXXK motif of AMSH interacts with the SH3 domains of the STAM and Grb2 families of adaptor proteins with high affinity."
20159979
sparser
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12–14] , we speculate that the neuronal cell death in the AMSH-deficient brain might be caused by the lack of interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"Whereas AMSH bound to both STAM1 and Grb2 ( Figs."
12810066
STAMBP inhibits GRB2.
| 1
STAMBP inhibits GRB2. 1 / 1
| 1
reach
"In the C. elegans peripheral chemosensory system, the amphid sheath glial cell (AMsh) is able to autonomously respond to aversive chemicals and consequently suppresses its amphid ASH neuron through GABA release to promote olfactory adaption (Duan et al., 2020)."
35069116
ScpA affects STAMBP
| 19
ScpA binds STAMBP. 10 / 19
| 19
sparser
"Our results also demonstrate that Lys63-Ub 2 and the AMSH-SBM share the same binding interface within the SH3 domain of STAM2."
27725184
sparser
"The AMSH-SBM outcompetes Lys63-Ub 2 for SH3 binding, while Lys63-Ub 2 can still bind the UIM domain of STAM2 in the presence of the AMSH-SBM."
27725184
sparser
"Based on the NMR structure of AMSH and STAM complex (PDB ID: 5IXF) from H. sapiens , Hologne et al. considered that the interaction of AMSH-SBM and STAM-SH3 contributed to the correct positioning of polyubiquitin chains toward AMSH before cleavage [ xref , xref ]."
35883466
sparser
"To address this question, we compared the interaction of the UIM-SH3 construct of the STAM2 protein with the SBM motif of AMSH (AMSH-SBM) or Lys63-linked diubiquitin (Lys63-Ub 2 )."
27725184
sparser
"Here, we show that Lys63-Ub 2 can bind either the UIM or the SH3 domain without any selectivity and that the AMSH-SBM can outcompete Lys63-Ub 2 for binding with the SH3 domain."
27725184
sparser
"Our results indicate that Lys63-Ub 2 can still bind the UIM domain when AMSH-SBM is bound to the SH3 domain of STAM2."
27725184
sparser
"Additionally, we have solved the structure of the UIM-SH3 construct in complex with AMSH-SBM."
27725184
sparser
"As no structural details are available yet, we tried to understand how the AMSH-SBM could interact with the SH3 domain of STAM."
27725184
sparser
"At this point, it is worth emphasizing that the sequence length of the AMSH-SBM has a direct effect on the kinetics of binding between AMSH and SH3 (see Table 1 )."
27725184
sparser
"Following our abovementioned results, we were seeking to understand how the AMSH-SBM could interact with the SH3 domain of STAM2 in the presence of Lys63-linked polyubiquitin chains."
27725184
USP8 affects STAMBP
1 | 3 15
STAMBP binds USP8. 8 / 8
| 3 5
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
sparser
"The interaction of the two endosomal DUBs, AMSH, and USP8 (UBPY in yeast), with a UIM-containing signal transducing adaptor molecule 2 (STAM2) enhances their deubiquitinating efficacy via substrate arrest [ xref , xref ]."
32512887
sparser
"Both AMSH and Usp8 bind components of the endosomal sorting complex for transport (ESCRT) which are involved in targeting ubiquitinated cargo receptors for incorporation into intraluminal vesicles (IL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and –III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
reach
"The DUBs AMSH (associated molecule with the SH3 domain of STAM) XREF_BIBR and UBPY (ubiquitin isopeptidase Y/ubiquitin specific protease 8) XREF_BIBR, bind both the ESCRT-0 component STAM (signal transducing adaptor molecule) and ESCRT and III complex members XREF_BIBR, and are implicated in regulating EGFR sorting onto the degradative pathway."
24295852
reach
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and -III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
sparser
"AMSH and Usp8 bind with their PxxP motif to the non-canonical SH3-binding motif of ESCRT-0 protein STAM, and with their MIT (Microtubule Interacting and Transport)-domain to several CHMP proteins of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"AMSH and USP8 can also interact with CHMP proteins that are components of the late ESCRT-III machinery xref , xref ."
26918171
STAMBP binds USP8 and STAM. 5 / 5
| 5
sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
26918171
USP8 binds STAMBP and CHMP1B. 1 / 1
1 |
hprd
No evidence text available
17711858
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
USP8 binds STAMBP and AVP. 1 / 1
| 1
sparser
"Like Doa4 in yeast, mammalian Usp8 and AMSH associate with class E Vps proteins on endosomes."
19489724
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
STAMBP affects scpA
| 19
ScpA binds STAMBP. 10 / 19
| 19
sparser
"Our results also demonstrate that Lys63-Ub 2 and the AMSH-SBM share the same binding interface within the SH3 domain of STAM2."
27725184
sparser
"The AMSH-SBM outcompetes Lys63-Ub 2 for SH3 binding, while Lys63-Ub 2 can still bind the UIM domain of STAM2 in the presence of the AMSH-SBM."
27725184
sparser
"Based on the NMR structure of AMSH and STAM complex (PDB ID: 5IXF) from H. sapiens , Hologne et al. considered that the interaction of AMSH-SBM and STAM-SH3 contributed to the correct positioning of polyubiquitin chains toward AMSH before cleavage [ xref , xref ]."
35883466
sparser
"To address this question, we compared the interaction of the UIM-SH3 construct of the STAM2 protein with the SBM motif of AMSH (AMSH-SBM) or Lys63-linked diubiquitin (Lys63-Ub 2 )."
27725184
sparser
"Here, we show that Lys63-Ub 2 can bind either the UIM or the SH3 domain without any selectivity and that the AMSH-SBM can outcompete Lys63-Ub 2 for binding with the SH3 domain."
27725184
sparser
"Our results indicate that Lys63-Ub 2 can still bind the UIM domain when AMSH-SBM is bound to the SH3 domain of STAM2."
27725184
sparser
"Additionally, we have solved the structure of the UIM-SH3 construct in complex with AMSH-SBM."
27725184
sparser
"As no structural details are available yet, we tried to understand how the AMSH-SBM could interact with the SH3 domain of STAM."
27725184
sparser
"At this point, it is worth emphasizing that the sequence length of the AMSH-SBM has a direct effect on the kinetics of binding between AMSH and SH3 (see Table 1 )."
27725184
sparser
"Following our abovementioned results, we were seeking to understand how the AMSH-SBM could interact with the SH3 domain of STAM2 in the presence of Lys63-linked polyubiquitin chains."
27725184
STAMBP affects USP8
1 | 3 15
STAMBP binds USP8. 8 / 8
| 3 5
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
sparser
"The interaction of the two endosomal DUBs, AMSH, and USP8 (UBPY in yeast), with a UIM-containing signal transducing adaptor molecule 2 (STAM2) enhances their deubiquitinating efficacy via substrate arrest [ xref , xref ]."
32512887
sparser
"Both AMSH and Usp8 bind components of the endosomal sorting complex for transport (ESCRT) which are involved in targeting ubiquitinated cargo receptors for incorporation into intraluminal vesicles (IL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and –III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
reach
"The DUBs AMSH (associated molecule with the SH3 domain of STAM) XREF_BIBR and UBPY (ubiquitin isopeptidase Y/ubiquitin specific protease 8) XREF_BIBR, bind both the ESCRT-0 component STAM (signal transducing adaptor molecule) and ESCRT and III complex members XREF_BIBR, and are implicated in regulating EGFR sorting onto the degradative pathway."
24295852
reach
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and -III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
sparser
"AMSH and Usp8 bind with their PxxP motif to the non-canonical SH3-binding motif of ESCRT-0 protein STAM, and with their MIT (Microtubule Interacting and Transport)-domain to several CHMP proteins of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"AMSH and USP8 can also interact with CHMP proteins that are components of the late ESCRT-III machinery xref , xref ."
26918171
STAMBP binds USP8 and STAM. 5 / 5
| 5
sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
26918171
USP8 binds STAMBP and CHMP1B. 1 / 1
1 |
hprd
No evidence text available
17711858
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
USP8 binds STAMBP and AVP. 1 / 1
| 1
sparser
"Like Doa4 in yeast, mammalian Usp8 and AMSH associate with class E Vps proteins on endosomes."
19489724
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
STAMBP affects CHMP1A
10 1 | 4 3
STAMBP binds CHMP1A. 10 / 16
10 1 | 3 1
biogrid
No evidence text available
33961781
reach
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19143619
biogrid
No evidence text available
16730941
reach
"AMSH interacts with ESCRT-III CHMP1 [XREF_BIBR, XREF_BIBR], CHMP2A and CHMP3 [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR, XREF_BIBR] as well as Ist1 [XREF_BIBR]."
21827950
reach
"AMSH also binds the ESCRT-III subunits CHMP1A, CHMP1B, and CHMP2A [7] ."
21531206
biogrid
No evidence text available
26186194
hprd
No evidence text available
16730941
biogrid
No evidence text available
28514442
biogrid
No evidence text available
16730941
biogrid
No evidence text available
16760479
STAMBP binds CHMP1A and MIT domain. 1 / 1
| 1
reach
"The AMSH MIT domain binds to CHMP1A, 1B, and 3 by multiple reports."
21332354
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
STAMBP binds CHMP1A and CHMP1B. 1 / 1
| 1
sparser
"Accordingly SPR measurements showed a much lower affinity for CHMP1A and CHMP1B interaction with AMSH ( xref )."
21827950
GRB2 affects STAMBP
12 1 | 1 4
STAMBP binds GRB2. 10 / 16
12 1 | 1 1
biogrid
No evidence text available
25416956
reach
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12-14], we speculate that the neuronal cell death in the AMSH deficient brain might be caused by the lack of interaction [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
biogrid
No evidence text available
12810066
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
20159979
biogrid
No evidence text available
21706016
biogrid
No evidence text available
20159979
hprd
No evidence text available
16730941
biogrid
No evidence text available
20159979
STAMBP binds STAM and GRB2. 3 / 3
| 3
sparser
"The RXXK motif of AMSH interacts with the SH3 domains of the STAM and Grb2 families of adaptor proteins with high affinity."
20159979
sparser
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12–14] , we speculate that the neuronal cell death in the AMSH-deficient brain might be caused by the lack of interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"Whereas AMSH bound to both STAM1 and Grb2 ( Figs."
12810066
CHMP1A affects STAMBP
10 1 | 4 3
STAMBP binds CHMP1A. 10 / 16
10 1 | 3 1
biogrid
No evidence text available
33961781
reach
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19143619
biogrid
No evidence text available
16730941
reach
"AMSH interacts with ESCRT-III CHMP1 [XREF_BIBR, XREF_BIBR], CHMP2A and CHMP3 [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR, XREF_BIBR] as well as Ist1 [XREF_BIBR]."
21827950
reach
"AMSH also binds the ESCRT-III subunits CHMP1A, CHMP1B, and CHMP2A [7] ."
21531206
biogrid
No evidence text available
26186194
hprd
No evidence text available
16730941
biogrid
No evidence text available
28514442
biogrid
No evidence text available
16730941
biogrid
No evidence text available
16760479
STAMBP binds CHMP1A and MIT domain. 1 / 1
| 1
reach
"The AMSH MIT domain binds to CHMP1A, 1B, and 3 by multiple reports."
21332354
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
STAMBP binds CHMP1A and CHMP1B. 1 / 1
| 1
sparser
"Accordingly SPR measurements showed a much lower affinity for CHMP1A and CHMP1B interaction with AMSH ( xref )."
21827950
STAMBP
7 | 4 6
STAMBP translocates.
| 4 6
STAMBP translocates to the endosome. 5 / 5
| 5
sparser
"In yeast, this deubiquitination step is carried out by the DUB hydrolase, Doa4 [66] , while in mammals the situation is more complex: two DUBs, USP8 (Ub Specific Protease 8, also called UBPY) and AMSH[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19007773
sparser
"Recruitment of both AMSH and USP8 to endosomes relies on binding to a distinct, but overlapping set of ESCRT III proteins via their respective MIT domains [168,173,174] ."
34895815
sparser
"When coexpressed with HA-STAM, we observed a dramatic recruitment of GFP-AMSH (D348A) to endosomes, effectively draining the nuclear pool (B, d–f)."
16431367
sparser
"The JAMM class enzyme AMSH is recruited to endosomes by the adaptor protein STAM [55] ."
26073511
sparser
"AMSH and UBPY are recruited to endosomes by interactions between their N-terminal MIT domains and late-acting ESCRT-III subunits [ 54–56,57 • ,59 ]."
18222686
STAMBP translocates to the early endosome. 3 / 3
| 3
reach
"Furthermore, AMSH binds clathrin directly and this interaction promotes AMSH recruitment to early endosomes [30,41]."
22800866
reach
"Further evidence that AMSH is involved in MVB sorting is given by the observation that AMSH binds clathrin directly and that this interaction promotes AMSH recruitment to early endosomes [30,41]."
22800866
reach
"Both AMSH and UBPY are recruited early in the pathway via interaction with the ESCRT-0 subunit STAM [XREF_BIBR - XREF_BIBR] and their localization to early endosomes is supported by interaction with the clathrin heavy chain [XREF_BIBR]."
21827950
STAMBP translocates to the gap junction. 1 / 1
| 1
reach
"AMSH is also recruited to GAP junction plaque sites and negatively regulates the turnover of the GAP junction protein Connexin 43 49."
28064438
STAMBP translocates to the membrane. 1 / 1
| 1
sparser
"Given this, an appropriate molecular model of the AMSH-CHMP3 complex is proposed, in which AMSH is first recruited to membranes early in the ESCRT pathway via ESCRT-0 STAM ( xref C) [ xref ]."
35883466
STAMBP is active.
5 |
STAMBP phosphorylated on S243 is active. 1 / 1
1 |
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
STAMBP phosphorylated on S245 is active. 1 / 1
1 |
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
STAMBP phosphorylated on S2 is active. 1 / 1
1 |
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
STAMBP phosphorylated on S247 is active. 1 / 1
1 |
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
STAMBP phosphorylated on S48 is active. 1 / 1
1 |
signor
"BMP type I receptor activation stimulates AMSH phosphorylation | The exact position of phosphoserine residues in four phosphopeptides was identified by Edman degradation analysis; spot a for Ser243, Ser245 and Ser247, spot b for Ser2, and spots c and d for Ser48. To confirm the position of the phosphoserine residues, the serine residue(s) in each phosphopeptide was replaced by alanine residues. Then, each mutant as well as wild‐type AMSH was transfected into COS7 cells in the absence or presence of caALK6, and tryptic phosphopeptide mapping of each mutant was performed. As seen in Figure 7, each spot corresponding to the phosphopeptide containing phosphoserine disappeared in the tryptic phosphopeptide mapping. | Thus, AMSH promotes BMP signaling by negatively regulating the function of I‐Smads."
11483516
STAMBP is inactive.
2 |
Ubiquitinated STAMBP is inactive. 1 / 1
1 |
signor
"RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome."
14755250
STAMBP bound to RNF11 is inactive. 1 / 1
1 |
signor
"RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome."
14755250
STAMBP affects RAI14
2 | 10 5
STAMBP binds RAI14.
2 | 3 5
STAMBP binds RAI14. 10 / 10
2 | 3 5
biogrid
No evidence text available
36434041
reach
"Immunoprecipitation-mass spectrometry combined with functional and morphological analysis verified the interaction between STAMBP and the actin-binding protein RAI14."
36434041
reach
"STAMBP knockdown led to the downregulation of LIMA1 in BT549 cells but not in MDA-MB-231 cells (Fig. 2c), indicating a context-dependent role for STAMBP in the regulation of LIMA1 expression.To further examine whether RAI14 acts as a direct substrate of STAMBP, we analyzed the interaction between STAMBP and RAI14."
36434041
reach
"Co-IP assays demonstrated the endogenous interaction of STAMBP and RAI14 in MDA-MB-231 and BT549 cells (Fig. 2d)."
36434041
sparser
"Immunoprecipitation–mass spectrometry combined with functional and morphological analysis verified the interaction between STAMBP and the actin-binding protein RAI14."
36434041
sparser
"STAMBP interacts with RAI14."
36434041
sparser
"To further examine whether RAI14 acts as a direct substrate of STAMBP, we analyzed the interaction between STAMBP and RAI14."
36434041
sparser
"Co-IP assays demonstrated the endogenous interaction of STAMBP and RAI14 in MDA-MB-231 and BT549 cells (Fig. xref )."
36434041
sparser
"Considering these results, we concluded that STAMBP directly interacts with RAI14 in TNBC cells."
36434041
biogrid
No evidence text available
36434041
STAMBP deubiquitinates RAI14.
| 3
STAMBP leads to the deubiquitination of RAI14. 3 / 3
| 3
reach
"As expected, overexpression of STAMBP rescued the ubiquitination of RAI14 caused by STAMBP knockdown (Fig. 3i)."
36434041
reach
"However, overexpression of STAMBP with a catalytically inactive site (D348A) failed to decrease the ubiquitination of the RAI14 protein (Supplementary Fig. 2), supporting the hypothesis that STAMBP DUB activity is required for RAI14 deubiquitination."
36434041
reach
"Recent studies have shown that the deubiquitinase STAMBP suppresses the ubiquitination of RAI14 and stabilizes its protein level, thereby promoting breast cancer progression (Yang et al, 2022)."
39160347
STAMBP increases the amount of RAI14.
| 2
STAMBP increases the amount of RAI14. 2 / 2
| 2
reach
"In contrast, overexpression of STAMBP increased RAI14 protein expression (Fig. 3g) and decreased the ubiquitination rate of RAI14 in MDA-MB-231 cells (Fig. 3h)."
36434041
reach
"These animal results demonstrated that STAMBP promoted TNBC progression partially by sustaining RAI14 expression in vivo."
36434041
STAMBP activates RAI14.
| 2
STAMBP activates RAI14. 2 / 2
| 2
reach
"In contrast, the knockdown of STAMBP accelerated RAI14 protein turnover to a greater extent than control shRNA (Fig. 3b)."
36434041
reach
"These data indicate that STAMBP-mediated RAI14 protein stability is necessary for RAI14-mediated EMT.Snail triggers EMT by inhibiting E-cadherin expression via a mechanism regulated by the UPS system [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37328395
STAMBP affects CHMP1B
11 2 | 2 1
STAMBP binds CHMP1B. 10 / 14
11 1 | 2
biogrid
No evidence text available
25416956
biogrid
No evidence text available
16730941
biogrid
No evidence text available
21988832
hprd
No evidence text available
16730941
reach
"Collectively data from these three different interaction studies provide strong evidence that the predicted interactions between CHMP1B and AMSH, CHMP3 and AMSH, and CHMP2A and LOC129531 may well be p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
biogrid
No evidence text available
16730941
biogrid
No evidence text available
16730941
biogrid
No evidence text available
17711858
biogrid
No evidence text available
17711858
biogrid
No evidence text available
32296183
USP8 binds STAMBP and CHMP1B. 1 / 1
1 |
hprd
No evidence text available
17711858
STAMBP binds CHMP1A and CHMP1B. 1 / 1
| 1
sparser
"Accordingly SPR measurements showed a much lower affinity for CHMP1A and CHMP1B interaction with AMSH ( xref )."
21827950
STAM2 affects STAMBP
6 2 | 3 5
STAM2 binds STAMBP.
6 2 | 2 5
STAM2 binds STAMBP. 10 / 15
6 2 | 2 5
sparser
"AMSH binds to the SH3 domain of STAM2."
24151880
reach
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
sparser
"JMS-175-2 did not inhibit AMSH* (a STAM2–AMSH fusion) xref ( xref ), showing that it is selective for BRISC over other zinc-dependent DUBs."
40097626
sparser
"Cezanne and enhanced versions of K48-specific OTUB1 (a UBE2D2–OTUB1 fusion named OTUB1*) and of a K63-specific AMSH (a STAM2–AMSH fusion named AMSH*) are used to cleave unwanted chains."
26470940
hprd
No evidence text available
16730941
hprd
No evidence text available
10899310
biogrid
No evidence text available
27725184
reach
"It thus demonstrates that STAM2 can bind to both AMSH and Lys63-Ub 2 at the same time by employing different UBDs."
27725184
biogrid
No evidence text available
20159979
biogrid
No evidence text available
16730941
STAM2 activates STAMBP.
| 1
STAM2 activates STAMBP. 1 / 1
| 1
reach
"Binding to its cofactor STAM2 stimulates AMSH deubiquitinating activity."
27012468
RNF11 affects STAMBP
2 3 1 | 6 4
RNF11 binds STAMBP.
1 3 1 | 2 4
RNF11 binds STAMBP. 10 / 10
1 3 1 | 2 3
sparser
"We have shown that RNF11 binds to AMSH and, in the presence of the E3 ligase Smurf2, promotes the ubiquitination and degradation of the AMSH protein [40]."
16925951
sparser
"It has also been reported that RNF11 binds to AMSH, a deubiquitinating enzyme that antagonizes the inhibitory effect exerted on the signaling pathway of TGF-β by the inhibitory (I-) SMADs, SMAD6 and SMAD7 [ xref ]."
33187263
hprd
No evidence text available
14755250
reach
"We have shown that RNF11 binds to AMSH and, in the presence of the E3 ligase Smurf2, promotes the ubiquitination and degradation of the AMSH protein [40]."
16925951
sparser
"RNF11 binds the DUB protein AMSH and promotes its degradation by the E3-ligase SMURF2-mediated ubiquitination [ xref ]."
33187263
biogrid
No evidence text available
14755250
signor
"RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome."
14755250
reach
"Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif."
14755250
biogrid
No evidence text available
14755250
biogrid
No evidence text available
14755250
RNF11 binds EPS15 and STAMBP. 1 / 1
| 1
sparser
"We found that RNF11 associates with EPS-15 and AMSH, which is the molecule associated with the SH3 domain of STAM (AMSH)."
16925951
RNF11 inhibits STAMBP.
| 3
RNF11 inhibits STAMBP. 3 / 3
| 3
reach
"The potential functions of RNF11 mediated degradation of AMSH in breast cancer are discussed."
14755250
reach
"Therefore, RNF11 rescues TGFbeta signalling and causes the degradation of AMSH through a Smurf2 mediated pathway, the implications of which are discussed further below.The TGFbetas belong to a super f[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16226459
reach
"Concomitantly, RNF11 cooperates with Smurf2 to degrade AMSH, an ubiquitin isopeptidase (a de-ubiquitination enzyme, DUB) that enhances TGFbeta signalling and EGFR-endosomal recycling [3,63]."
16226459
RNF11 ubiquitinates STAMBP.
| 1
RNF11 leads to the ubiquitination of STAMBP. 1 / 1
| 1
reach
"RNF11 may mediate AMSH ubiquitination through the formation of the Smurf2/RNF11 complex, leading to its degradation by the 26S proteasome, negatively regulating TGF-β signaling (199)."
39185411
RNF11 decreases the amount of STAMBP.
1 |
RNF11 decreases the amount of STAMBP. 1 / 1
1 |
signor
"RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome."
14755250
CHMP1B affects STAMBP
11 2 | 2 1
STAMBP binds CHMP1B. 10 / 14
11 1 | 2
biogrid
No evidence text available
25416956
biogrid
No evidence text available
16730941
biogrid
No evidence text available
21988832
hprd
No evidence text available
16730941
reach
"Collectively data from these three different interaction studies provide strong evidence that the predicted interactions between CHMP1B and AMSH, CHMP3 and AMSH, and CHMP2A and LOC129531 may well be p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
biogrid
No evidence text available
16730941
biogrid
No evidence text available
16730941
biogrid
No evidence text available
17711858
biogrid
No evidence text available
17711858
biogrid
No evidence text available
32296183
USP8 binds STAMBP and CHMP1B. 1 / 1
1 |
hprd
No evidence text available
17711858
STAMBP binds CHMP1A and CHMP1B. 1 / 1
| 1
sparser
"Accordingly SPR measurements showed a much lower affinity for CHMP1A and CHMP1B interaction with AMSH ( xref )."
21827950
UBC affects STAMBP
15 |
STAMBP binds UBC. 10 / 15
15 |
biogrid
No evidence text available
24961813
biogrid
No evidence text available
25527291
biogrid
No evidence text available
24151880
biogrid
No evidence text available
20622874
biogrid
No evidence text available
26601948
biogrid
No evidence text available
26601948
biogrid
No evidence text available
16431367
biogrid
No evidence text available
28319114
biogrid
No evidence text available
23562397
biogrid
No evidence text available
26876099
STAMBP affects STAM2
6 2 | 2 5
STAM2 binds STAMBP. 10 / 15
6 2 | 2 5
sparser
"AMSH binds to the SH3 domain of STAM2."
24151880
reach
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
sparser
"JMS-175-2 did not inhibit AMSH* (a STAM2–AMSH fusion) xref ( xref ), showing that it is selective for BRISC over other zinc-dependent DUBs."
40097626
sparser
"Cezanne and enhanced versions of K48-specific OTUB1 (a UBE2D2–OTUB1 fusion named OTUB1*) and of a K63-specific AMSH (a STAM2–AMSH fusion named AMSH*) are used to cleave unwanted chains."
26470940
hprd
No evidence text available
16730941
hprd
No evidence text available
10899310
biogrid
No evidence text available
27725184
reach
"It thus demonstrates that STAM2 can bind to both AMSH and Lys63-Ub 2 at the same time by employing different UBDs."
27725184
biogrid
No evidence text available
20159979
biogrid
No evidence text available
16730941
STAMBP affects Neoplasm Invasiveness
| 3 12
reach
"Furthermore, knockdown of STAMBP expression reduced cell mobility and invasion of breast cancer cells."
36309616
reach
"Performing functional experiments, we further demonstrated that the upregulation of STAMBP promoted the proliferation and invasion of TNBC cells, while the knockdown of STAMBP suppressed the malignant progression of TNBC cells."
36434041
eidos
"STAMBP knockdown inhibits cell motility and invasion by attenuating MAPK signaling We used 2 siRNA fragments to reduce STAMBP expression in H1299 and A549 cells and then examined the ability of the cells to proliferate , migrate and invade ."
34102455
reach
"Previous studies have shown that STAMBP promotes the migration and invasion of lung cancer and melanoma cells ."
36434041
eidos
"Knockdown of STAMBP inhibits cell motility and invasion by attenuating MAPK signaling ."
34102455
reach
"Functionally, the knockdown of STAMBP inhibited the proliferation, migration, and invasion of multiple TNBC cell lines."
36434041
reach
"STAMBP overexpression promoted cell migration and invasion, whereas STAMBP knockdown attenuated these processes in LUAD cells after epidermal growth factor treatment."
34102455
reach
"Small molecule inhibitors of EGFR and MAPK signaling pathway may block STAMBP induced cell mobility and invasion as well as ERK activation in cells."
34102455
reach
"The wound healing (Fig. 1e) and Transwell assays (Fig. 1f) further demonstrated that the silencing of STAMBP impaired the migration and invasion of MDA-MB-231 and BT549 cells."
36434041
reach
"The hypothesis that STAMBP mediates tumor cell growth, invasion, and migration was confirmed by the overexpression of STAMBP after gene transfection (Fig. 1g–j)."
36434041
STAMBP affects NLRP3
2 1 | 9 2
STAMBP deubiquitinates NLRP3.
| 5
STAMBP deubiquitinates NLRP3. 5 / 5
| 5
reach
"3.3 STAMBP deubiquitinates NLRP3 but does not regulate its degradation.."
33253913
reach
"Therefore, the deubiquitination of NLRP3 by STAMBP acts as a negative regulator for NLRP3 inflammasome activation [109] 5.1.3."
| PMC
reach
"We hypothesized that STAMBP deubiquitinates NLRP3, which modulates NLRP3 activity."
33253913
reach
"STAMBP deubiquitinates NLRP3."
33253913
reach
"STAMBP also inhibits excessive activation of the inflammasome by preventing the nondegradative ubiquitination of NLRP3 ."
36434041
STAMBP ubiquitinates NLRP3.
1 | 2 1
STAMBP leads to the ubiquitination of NLRP3. 4 / 4
1 | 2 1
reach
"In this study, we demonstrate STAMBP-mediated ubiquitination of NLRP3 to provide a non- degradative signal, and STAMBP knockout increased IL-1β secretion in undifferentiated THP-1 monocytes (Fig. 2)."
33253913
ubibrowser
"These findings describe a unique mechanism of non-degradative ubiquitination of <span class="match term1">NLRP3</span> by <span class="match term0">STAMBP</span> to limit excessive inflammasome activation and to reduce injurious IL-1beta signaling."
33253913
sparser
"These findings describe a unique mechanism of non-degradative ubiquitination of NLRP3 by STAMBP to limit excessive inflammasome activation and to reduce injurious IL-1β signaling."
33253913
reach
"Collectively, these data support a functional relationship via physical association of NLRP3 with STAMBP, whereby STAMBP modulates NLRP3 polyubiquitination through its catalytic activity."
33253913
STAMBP binds NLRP3.
2 | 1
STAMBP binds NLRP3. 3 / 3
2 | 1
biogrid
No evidence text available
33253913
sparser
"Collectively, these data support a functional relationship via physical association of NLRP3 with STAMBP, whereby STAMBP modulates NLRP3 polyubiquitination through its catalytic activity."
33253913
biogrid
No evidence text available
32003754
STAMBP inhibits NLRP3.
| 1
STAMBP inhibits NLRP3. 1 / 1
| 1
reach
"NLRP3 inflammasome activity as shown above is activated by STAMBP knockout in THP-1 cells."
33253913
STAMBP activates NLRP3.
| 1
STAMBP activates NLRP3. 1 / 1
| 1
reach
"Instead, STAMBP triggers NLRP3 K63-linked polyubiquitination in response to endotoxin, which seems to function as an activating and non-degradative signal for the NLRP3 inflammasome."
33253913
STAMBP affects GRAP2
8 4 | 1 1
GRAP2 binds STAMBP. 10 / 13
8 4 | 1
biogrid
No evidence text available
28514442
biogrid
No evidence text available
10224278
biogrid
No evidence text available
26186194
biogrid
No evidence text available
20159979
reach
"These results are consistent with previous studies showing that Gads interacts with Gab1 and AMSH in vitro [6, 10, 12]."
12176364
biogrid
No evidence text available
16730941
hprd
No evidence text available
12773374
hprd
No evidence text available
12176364
hprd
No evidence text available
10224278
hprd
No evidence text available
16730941
GRAP2 binds GAB1 and STAMBP. 1 / 1
| 1
sparser
"These results are consistent with previous studies showing that Gads interacts with Gab1 and AMSH in vitro [6, 10, 12] ."
12176364
Ubiquitin affects STAMBP
| 1 8 1
Ubiquitin binds STAMBP. 6 / 8
| 1 5
sparser
"To develop potent and specific inhibitors for STAMBP, we decided to employ a structure-based combinatorial Ub engineering strategy to inhibit the Ub-STAMBP protein–protein interaction ( xref ) selectively."
34425109
sparser
"Using the STAMBP crystal structure xref (3RZU.pdb) and the structure of the nearly identical DUB domain of STAMBPL1 in complex with a di-Ub chain (2ZNV.pdb xref ), we used in silico molecular modelling to simulate the interaction between STAMBP and Ub ( xref )."
28492230
sparser
"Because the crystal structure of AMSH bound to ubiquitin is not known, we took advantage of our structure to gain insights into possible effects the mutation may have on the structure of AMSH and its ubiquitin recognition. xref "
24787148
sparser
"AMSH-LP has no functional SBM or MIT (microtubule interacting and transport) domain, and therefore cannot bind to other components of the ESCRT machinery, but a host of experimental studies have shown that the STAM protein connected to AMSH in a more subtle manner and serves as an activator of this enzymatic process [ xref , xref ], with the UIM domain of STAM serving as an activator in interactions with the proximal Ub of Lys63-Ub 2 and AMSH interacting with the distal Ub."
25396681
reach
"pdb) and the structure of the nearly identical DUB domain of STAMBPL1 in complex with a di-Ub chain, we used in silico molecular modelling to simulate the interaction between STAMBP and Ub (XREF_SUPPLEMENTARY)."
28492230
sparser
"Biophysical characterization of ubiquitin binding to the catalytic domain of AMSH."
24151880
STAMBP binds RIPK2 and Ubiquitin. 1 / 1
| 1
sparser
"Next we purified ubiquitin conjugates from L18-MDP-stimulated Mysm1 − /− BMDMs by TUBE and incubated them with recombinant MYSM1 (Rec-MYSM1) and compared the ubiquitin restriction pattern of Ub-RIP2 with that of AMSH, UCHL3, OTULIN or a combination of these three DUBs (Fig.  xref )."
30405132
NLRP7 binds Ubiquitin and STAMBP. 1 / 1
| 1
sparser
"Further, we introduce the small molecule BC-1471, which interrupts STAMBP-Ub-NALP7 interaction and suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, peripheral blood mononuclear cells and lung organ culture."
28492230
STAMBP binds K63 and Ubiquitin. 1 / 1
| 1
sparser
"This is best illustrated by the structure obtained for a catalytically inactive variant of AMSH bound to K63-linked Ub dimer ( xref )."
22196026
Ubiquitin binds STAMBP. 1 / 1
| 1
isi
"By downregulating candidate deubiquitinases that are either linked with GPCR trafficking or localized on endosomes, we identified signal-transducing adaptor molecule binding protein (STAMBP) and ubiquitin specific protease 33 (USP33) as cognate deubiquitinases for the GCGR."
32967969
STAMBPL1 affects STAMBP
2 | 4 6
STAMBPL1 binds STAMBP.
2 | 2 5
STAMBPL1 binds STAMBP. 8 / 8
2 | 2 4
sparser
"Unlike the monomer of AMSH or AMSH-LP with inherent DUB activity, BRCC36 must form a complex with other subunits to specifically cleave K63-linked polyubiquitin chains."
35883466
sparser
"To quantify the interaction of the UbVs with STAMBP and STAMBPL1 and to validate the key residues responsible for the tight binding, we used isothermal titration calorimetry (ITC) to measure the interaction thermodynamics ( xref )."
34425109
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
biogrid
No evidence text available
28514442
sparser
"Hence, it is possible that AMSH and AMSH-LP might be associated with a proteasome or other unknown large protein complex in the nucleus through their MPN domain."
12810066
biogrid
No evidence text available
33961781
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBPL1 inhibits STAMBP.
| 2
STAMBPL1 inhibits STAMBP. 2 / 2
| 2
reach
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of fulllength STAMBP activated by STAM protein and full-length STAMBPL1."
| DOI
reach
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
STAMBPL1 activates STAMBP.
| 1
STAMBPL1 activates STAMBP. 1 / 1
| 1
sparser
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
STAMBP affects SMAD6
3 1 | 4 2
STAMBP binds SMAD6.
3 1 | 1 2
STAMBP binds SMAD6. 7 / 8
3 1 | 1 2
biogrid
No evidence text available
11483516
biogrid
No evidence text available
11483516
reach
"AMSH interacts with Smad6, but not with R- and Co-Smads, upon BMP receptor activation in cultured cells."
11483516
hprd
No evidence text available
11483516
sparser
"AMSH interacts with Smad6, but not with R- and Co-Smads, upon BMP receptor activation in cultured cells."
11483516
sparser
"AMSH interacts with Smad6, but not with R- and Co-Smads, following BMP receptor activation."
14687659
biogrid
No evidence text available
11483516
STAMBP inhibits SMAD6.
| 3
STAMBP inhibits SMAD6. 3 / 3
| 3
reach
"It has been proposed that AMSH sequesters SMAD6, thus impeding its inhibitory role on the BMP pathway and thereby resulting in a prolonged BMP signalling."
25007997
reach
"Smad6 can be sequestered by the protein AMSH upon nuclear export in response to BMP (Itoh et al., 2001)."
12809600
reach
"AMSH has been reported to antagonise Smad6 function, and promote BMP signalling."
27155333
STAMBP affects RNF11
1 3 1 | 2 4
RNF11 binds STAMBP. 10 / 10
1 3 1 | 2 3
sparser
"We have shown that RNF11 binds to AMSH and, in the presence of the E3 ligase Smurf2, promotes the ubiquitination and degradation of the AMSH protein [40]."
16925951
sparser
"It has also been reported that RNF11 binds to AMSH, a deubiquitinating enzyme that antagonizes the inhibitory effect exerted on the signaling pathway of TGF-β by the inhibitory (I-) SMADs, SMAD6 and SMAD7 [ xref ]."
33187263
hprd
No evidence text available
14755250
reach
"We have shown that RNF11 binds to AMSH and, in the presence of the E3 ligase Smurf2, promotes the ubiquitination and degradation of the AMSH protein [40]."
16925951
sparser
"RNF11 binds the DUB protein AMSH and promotes its degradation by the E3-ligase SMURF2-mediated ubiquitination [ xref ]."
33187263
biogrid
No evidence text available
14755250
signor
"RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome."
14755250
reach
"Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif."
14755250
biogrid
No evidence text available
14755250
biogrid
No evidence text available
14755250
RNF11 binds EPS15 and STAMBP. 1 / 1
| 1
sparser
"We found that RNF11 associates with EPS-15 and AMSH, which is the molecule associated with the SH3 domain of STAM (AMSH)."
16925951
STAMBP affects CHMP2A
5 | 3 2
CHMP2A binds STAMBP. 9 / 10
5 | 3 1
reach
"Collectively data from these three different interaction studies provide strong evidence that the predicted interactions between CHMP1B and AMSH, CHMP3 and AMSH, and CHMP2A and LOC129531 may well be p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
reach
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19143619
biogrid
No evidence text available
17159328
reach
"AMSH also binds the ESCRT-III subunits CHMP1A, CHMP1B, and CHMP2A [7] ."
21531206
biogrid
No evidence text available
16760479
sparser
"Arl4A overexpression resulted in a reduction in the interaction between CHMP2A and USP8/UBPY but not AMSH (Fig.  xref )."
38030597
biogrid
No evidence text available
16760479
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
SMURF2 affects STAMBP
2 2 1 | 4 1
SMURF2 ubiquitinates STAMBP.
1 1 | 3 1
SMURF2 ubiquitinates STAMBP. 6 / 7
1 1 | 3 1
ubibrowser
"Our results also demonstrate that <span class="match term1">AMSH</span> is ubiquitinated by <span class="match term0">Smurf2</span> E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and <span class="match term0">Smurf2</span>"
14755250
sparser
"The protein levels of AMSH decrease in presence of both RNF11 and SMURF2, and AMSH is ubiquitinated by SMURF2 in the presence of RNF11."
33187263
signor
"RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome."
14755250
reach
"Li and Seth [58] have demonstrated that AMSH itself is ubiquitinated by Smurf2, the E3 ligase that is responsible for TGF-β receptor and I-Smad ubiquitination and degradation."
16996268
reach
"Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2."
14755250
reach
"An RNF11 : Smurf2 complex mediates ubiquitination of the AMSH protein."
14755250
SMURF2 binds STAMBP.
2 |
SMURF2 binds STAMBP. 2 / 2
2 |
biogrid
No evidence text available
14755250
biogrid
No evidence text available
14755250
SMURF2 decreases the amount of STAMBP.
1 |
SMURF2 decreases the amount of STAMBP. 1 / 1
1 |
signor
"RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome."
14755250
SMURF2 activates STAMBP.
| 1
SMURF2 activates STAMBP. 1 / 1
| 1
reach
"An RNF11 : Smurf2 complex mediates ubiq uitination of the AMSH protein."
16925951
CHMP2A affects STAMBP
5 | 3 2
CHMP2A binds STAMBP. 9 / 10
5 | 3 1
reach
"Collectively data from these three different interaction studies provide strong evidence that the predicted interactions between CHMP1B and AMSH, CHMP3 and AMSH, and CHMP2A and LOC129531 may well be p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
reach
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19143619
biogrid
No evidence text available
17159328
reach
"AMSH also binds the ESCRT-III subunits CHMP1A, CHMP1B, and CHMP2A [7] ."
21531206
biogrid
No evidence text available
16760479
sparser
"Arl4A overexpression resulted in a reduction in the interaction between CHMP2A and USP8/UBPY but not AMSH (Fig.  xref )."
38030597
biogrid
No evidence text available
16760479
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
STAMBP activates cell population proliferation. 7 / 7
| 7
reach
"Using the human cortical organoids (hCOs) model, we showed that the STAMBP deficiency disrupts the proliferation of neural stem cells (NSCs), leading to a dramatic size reduction in hCOs."
36033615
reach
"Performing functional experiments, we further demonstrated that the upregulation of STAMBP promoted the proliferation and invasion of TNBC cells, while the knockdown of STAMBP suppressed the malignant progression of TNBC cells."
36434041
reach
"STAMBP deletion results in smaller cortical organoids and impairs neural stem cell proliferation."
36033615
reach
"Functionally, the knockdown of STAMBP inhibited the proliferation, migration, and invasion of multiple TNBC cell lines."
36434041
reach
"Knockdown of STAMBP could inhibit the proliferation, migration and invasion of multiple TNBC cell lines [28]."
38449391
reach
"Overexpression of STAMBP released RAI14 knockdown-induced inhibition of cell proliferation (Supplementary Fig. 3b), cell migration (Supplementary Fig. 3c) and cell invasion (Supplementary Fig. 3d)."
36434041
reach
"Novel compound heterozygous mutation in STAMBP causes a neurodevelopmental disorder by disrupting cortical proliferation."
36033615
reach
"After re-expressing wild-type STAMBP, STAMBP G307E , and STAMBP T313I (a known pathogenic mutation) within STAMBP KO organoids, only STAMBP WT rescued the impaired proliferation of STAMBP deficient organoids, but not STAMBP G307E and STAMBP T313I ."
36033615
reach
"After re-expressing wild-type STAMBP, STAMBP G307E , and STAMBP T313I (a known pathogenic mutation) within STAMBP KO organoids, only STAMBP WT rescued the impaired proliferation of STAMBP deficient organoids, but not STAMBP G307E and STAMBP T313I ."
36033615
STAMBP inhibits cell population proliferation. 1 / 1
| 1
sparser
"The immunoregulatory factors VIP and α-MSH significantly inhibited lymphatic endothelial cell proliferation in vitro."
27918829
RAI14 affects STAMBP
2 | 3 5
STAMBP binds RAI14. 10 / 10
2 | 3 5
biogrid
No evidence text available
36434041
reach
"Immunoprecipitation-mass spectrometry combined with functional and morphological analysis verified the interaction between STAMBP and the actin-binding protein RAI14."
36434041
reach
"STAMBP knockdown led to the downregulation of LIMA1 in BT549 cells but not in MDA-MB-231 cells (Fig. 2c), indicating a context-dependent role for STAMBP in the regulation of LIMA1 expression.To further examine whether RAI14 acts as a direct substrate of STAMBP, we analyzed the interaction between STAMBP and RAI14."
36434041
reach
"Co-IP assays demonstrated the endogenous interaction of STAMBP and RAI14 in MDA-MB-231 and BT549 cells (Fig. 2d)."
36434041
sparser
"Immunoprecipitation–mass spectrometry combined with functional and morphological analysis verified the interaction between STAMBP and the actin-binding protein RAI14."
36434041
sparser
"STAMBP interacts with RAI14."
36434041
sparser
"To further examine whether RAI14 acts as a direct substrate of STAMBP, we analyzed the interaction between STAMBP and RAI14."
36434041
sparser
"Co-IP assays demonstrated the endogenous interaction of STAMBP and RAI14 in MDA-MB-231 and BT549 cells (Fig. xref )."
36434041
sparser
"Considering these results, we concluded that STAMBP directly interacts with RAI14 in TNBC cells."
36434041
biogrid
No evidence text available
36434041
STAMBP affects STAMBPL1
2 | 2 5
STAMBPL1 binds STAMBP. 8 / 8
2 | 2 4
sparser
"Unlike the monomer of AMSH or AMSH-LP with inherent DUB activity, BRCC36 must form a complex with other subunits to specifically cleave K63-linked polyubiquitin chains."
35883466
sparser
"To quantify the interaction of the UbVs with STAMBP and STAMBPL1 and to validate the key residues responsible for the tight binding, we used isothermal titration calorimetry (ITC) to measure the interaction thermodynamics ( xref )."
34425109
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
biogrid
No evidence text available
28514442
sparser
"Hence, it is possible that AMSH and AMSH-LP might be associated with a proteasome or other unknown large protein complex in the nucleus through their MPN domain."
12810066
biogrid
No evidence text available
33961781
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBP is modified
| 9
STAMBP is ubiquitinated.
| 5
STAMBP is ubiquitinated. 5 / 5
| 5
sparser
"The difference is that STAMBP does not affect the protein abundance of NLRP3, but STAMBP deficiency enhances the K63-linked ubiquitin chain of NLRP3, and the non-degraded STAMBP ubiquitination process favors NLRP3 inflammasome activation ( xref )."
34966378
sparser
"We have shown that RNF11 binds to AMSH and, in the presence of the E3 ligase Smurf2, promotes the ubiquitination and degradation of the AMSH protein [40]."
16925951
sparser
"It acts as an adaptor for the Smurf2-mediated ubiquitylation of AMSH, a deubiquitylating enzyme acting in the endocytic pathway, leading to its degradation [47] ."
19070615
sparser
"RNF11 may mediate AMSH ubiquitination through the formation of the Smurf2/RNF11 complex, leading to its degradation by the 26S proteasome, negatively regulating TGF-β signaling ( xref )."
39185411
sparser
"MS analysis of EGFR-AMSH ubiquitination demonstrated that the fraction of K63 linkages was substantially reduced, whereas relative amounts of monoubiquitin and K48 linkages increased, compared with that of wild-type EGFR."
24019463
STAMBP is phosphorylated.
| 2
STAMBP is phosphorylated. 2 / 2
| 2
sparser
"α-Viniferin inhibited α-MSH- or db-cAMP-induced CREB phosphorylation and CRTC1 dephosphorylation."
29556371
sparser
"However, comparison of the interaction of wild-type Smad6 and its methylation-defective mutant with the activated BMP type I receptors, Smurfs, arkadia, phosphorylated Smad1, TAK1, TAB1, CtBP, AMSH an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17118358
STAMBP is acetylated.
| 2
STAMBP is acetylated. 2 / 2
| 2
sparser
"However, it has been hypothesized that the regulation of α-Msh acetylation may be an important mechanism for background adaptation, more than total amounts of α-Msh released into the blood ( Arends et[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33220300
sparser
"Still, specific posttranslational modifying enzymes remain to be identified, for example the enzymes responsible for the acetylation of the secretory peptides β-endorphin and α-MSH."
19412546
Clathrin affects STAMBP
| 5 4
Clathrin binds STAMBP.
| 4 4
STAMBP binds Clathrin. 7 / 7
| 4 3
sparser
"Furthermore, AMSH interacts directly with clathrin [31,40] and through its MIT domain with several charged multivesicular body proteins – also known as chromatin-modifying protein – (CHMP) proteins, s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16996268
sparser
"Further evidence that AMSH is involved in MVB sorting is given by the observation that AMSH binds clathrin directly and that this interaction promotes AMSH recruitment to early endosomes [30,41] ."
22800866
reach
"Furthermore, AMSH binds clathrin directly and this interaction promotes AMSH recruitment to early endosomes [30,41]."
22800866
sparser
"Furthermore, AMSH binds clathrin directly and this interaction promotes AMSH recruitment to early endosomes [30,41] ."
22800866
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
reach
"Further evidence that AMSH is involved in MVB sorting is given by the observation that AMSH binds clathrin directly and that this interaction promotes AMSH recruitment to early endosomes [30,41]."
22800866
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
Clathrin deubiquitinates STAMBP.
| 1
Clathrin deubiquitinates STAMBP. 1 / 1
| 1
reach
"Clathrin anchors deubiquitinating enzymes, AMSH and AMSH like protein, on early endosomes."
16716190
P3 affects STAMBP
| 8
P3 binds STAMBP. 8 / 8
| 8
sparser
"To gain insight into the orientation of AMSH with respect to SH3, we used different AMSH peptide sequence containing either the P 239 (AMSH-P3) or the 230 PP 231 (AMSH-P4) motif."
27725184
sparser
"First, the UIM-SH3 CSP mapping shows different intensities with AMSH-P3 and -P4, especially for residues Tyr218 and Asp219 (see Fig. 2 c and d)."
27725184
sparser
"Second, the 1 H, 15 N-HSQC signals corresponding to the interaction between UIM-SH3 and AMSH-P3 are in the fast exchange regime compared to the UIM-SH3/AMSH-P4 complex that underwent signals in the in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"Third, the directions of the shifts in the 1 H, 15 N-HSQC spectra of UIM-SH3 upon titration by AMSH-P3 and -P4 are similar (Figs."
27725184
sparser
"While AMSH-P3 and -P4 have similar dissociation constants upon binding to SH3 (see Table 1 ), the dissociation rate constant for the UIM-SH3/AMSH-P3 complex rose significantly to 3900 ± 1500s − 1 (res[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"In the light of these observations, it is likely that the P 239 residue of AMSH-P3 would be oriented in a direction close to the residues Trp246 and Glu224 of SH3, while 230 PP 231 of AMSH-P4 would po[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"These results, which added to the fact that AMSH-P3 still binds to SH3, indicate that the Lys 238 residue has a profound effect on the binding of AMSH with SH3."
27725184
sparser
"While 231 PVVDRSLKP 239 is the sequence that would maintain AMSH in the correct orientation with respect to STAM, the removal of 228 AKPP 231 (AMSH-P3) only slightly affects the binding affinity while[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
STAMBP affects PRF1
| 8
PRF1 binds STAMBP. 8 / 8
| 8
sparser
"Some residues show a strong signal decrease at an early stage of the titration but it is less pronounced compared to AMSH-P1 (Figs."
27725184
sparser
"We monitored CSPs on a 15 N-UIM-SH3 sample upon titration by AMSH-P1 and made different observations."
27725184
sparser
"The AMSH-P1 peptide, which contains the minimum sequence length for the AMSH-SBM, binds to SH3 with a dissociation constant of 2.0 ± 0.7 μM and a dissociation rate constant ( k off ) of 117 ± 43 s − 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"It is also noticeable from our ensemble of titration experiments that the directions of the shifts on UIM-SH3 are similar to that of the complete set of peptides from AMSH-P1 to AMSH-P8."
27725184
sparser
"To address this question, we used the peptide sequence 231 PVVDRSLKP 239 (further denoted by AMSH-P1), known to be a shared STAM-binding motif [7,30] ."
27725184
sparser
"As a consequence, it can be inferred that the mode of binding experienced by AMSH-P1 or Lys63-Ub 2 with SH3 is different."
27725184
sparser
"The kinetic information provided here reveals a residence time of 8.5 ms for AMSH-P1, comparable with other SH3/peptide systems [34,35] and characteristic of a transient interaction."
27725184
sparser
"To address this question, we used different variants of the SBM sequence ( Table 2 ) and the same approach as that for AMSH-P1."
27725184
STAMBP affects IL1B
| 8
STAMBP decreases the amount of IL1B.
| 6
STAMBP decreases the amount of IL1B. 6 / 6
| 6
reach
"This exaggerated inflammatory response was dependent on IL-1beta signaling, and STAMBP knockout directly increased release of IL-1beta with TLR ligation."
33253913
reach
"In a monocyte cell line, genetic knockout of STAMBP increases IL-1β secretion and increases subsequent IL-1β-driven cytokine and chemokine gene expression."
33253913
reach
"3.2 STAMBP knockout increases IL-1beta secretion in THP-1 monocytes after endotoxin.."
33253913
reach
"Our group previously demonstrated a functional relationship between STAMBP and another inflammasome protein NLRP7, whereby STAMBP knockdown enhanced NLRP7 degradation and decreased IL-1β release in differentiated THP-1 macrophages (20)."
33253913
reach
"In this study, we demonstrate STAMBP-mediated ubiquitination of NLRP3 to provide a non- degradative signal, and STAMBP knockout increased IL-1β secretion in undifferentiated THP-1 monocytes (Fig. 2)."
33253913
reach
"Moreover, STAMBP deficiency increases the IL-1β gene expression and cytokine level in response to LPS, and showed an increase in ASC speck and active caspase-1 levels."
| PMC
STAMBP activates IL1B.
| 2
STAMBP activates IL1B. 2 / 2
| 2
reach
"We hypothesized that targeting of STAMBP DUB activity to destabilize NALP7 will decrease NALP7 inflammasome activity, namely secretion of mature IL-1beta."
28492230
reach
"Our finding that STAMBP knockdown reduces IL-1beta secretion suggest that much of this effect is from NALP7 destabilization, but further study is needed to determine if endosomal trafficking and interaction with STAMBP is a required step for inflammasome assembly."
28492230
STAMBP affects Clathrin
| 4 4
STAMBP binds Clathrin. 7 / 7
| 4 3
sparser
"Furthermore, AMSH interacts directly with clathrin [31,40] and through its MIT domain with several charged multivesicular body proteins – also known as chromatin-modifying protein – (CHMP) proteins, s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16996268
sparser
"Further evidence that AMSH is involved in MVB sorting is given by the observation that AMSH binds clathrin directly and that this interaction promotes AMSH recruitment to early endosomes [30,41] ."
22800866
reach
"Furthermore, AMSH binds clathrin directly and this interaction promotes AMSH recruitment to early endosomes [30,41]."
22800866
sparser
"Furthermore, AMSH binds clathrin directly and this interaction promotes AMSH recruitment to early endosomes [30,41] ."
22800866
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
reach
"Further evidence that AMSH is involved in MVB sorting is given by the observation that AMSH binds clathrin directly and that this interaction promotes AMSH recruitment to early endosomes [30,41]."
22800866
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBP affects CLTC
6 | 2
STAMBP binds CLTC. 7 / 7
6 | 1
biogrid
No evidence text available
16431367
sparser
"Further interactions between AMSH and other trafficking accessory proteins such as clathrin heavy chain and a component of ESCRT III indicate that AMSH is “deeply integrated as a hub protein within the MVB-sorting protein interaction network” ( xref )."
16702236
biogrid
No evidence text available
16431367
biogrid
No evidence text available
16431367
biogrid
No evidence text available
16716190
biogrid
No evidence text available
16716190
biogrid
No evidence text available
26496610
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
SMAD6 affects STAMBP
3 1 | 1 2
STAMBP binds SMAD6. 7 / 8
3 1 | 1 2
biogrid
No evidence text available
11483516
biogrid
No evidence text available
11483516
reach
"AMSH interacts with Smad6, but not with R- and Co-Smads, upon BMP receptor activation in cultured cells."
11483516
hprd
No evidence text available
11483516
sparser
"AMSH interacts with Smad6, but not with R- and Co-Smads, upon BMP receptor activation in cultured cells."
11483516
sparser
"AMSH interacts with Smad6, but not with R- and Co-Smads, following BMP receptor activation."
14687659
biogrid
No evidence text available
11483516
PRF1 affects STAMBP
| 8
PRF1 binds STAMBP. 8 / 8
| 8
sparser
"Some residues show a strong signal decrease at an early stage of the titration but it is less pronounced compared to AMSH-P1 (Figs."
27725184
sparser
"We monitored CSPs on a 15 N-UIM-SH3 sample upon titration by AMSH-P1 and made different observations."
27725184
sparser
"The AMSH-P1 peptide, which contains the minimum sequence length for the AMSH-SBM, binds to SH3 with a dissociation constant of 2.0 ± 0.7 μM and a dissociation rate constant ( k off ) of 117 ± 43 s − 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"It is also noticeable from our ensemble of titration experiments that the directions of the shifts on UIM-SH3 are similar to that of the complete set of peptides from AMSH-P1 to AMSH-P8."
27725184
sparser
"To address this question, we used the peptide sequence 231 PVVDRSLKP 239 (further denoted by AMSH-P1), known to be a shared STAM-binding motif [7,30] ."
27725184
sparser
"As a consequence, it can be inferred that the mode of binding experienced by AMSH-P1 or Lys63-Ub 2 with SH3 is different."
27725184
sparser
"The kinetic information provided here reveals a residence time of 8.5 ms for AMSH-P1, comparable with other SH3/peptide systems [34,35] and characteristic of a transient interaction."
27725184
sparser
"To address this question, we used different variants of the SBM sequence ( Table 2 ) and the same approach as that for AMSH-P1."
27725184
CLTC affects STAMBP
6 | 2
STAMBP binds CLTC. 7 / 7
6 | 1
biogrid
No evidence text available
16431367
sparser
"Further interactions between AMSH and other trafficking accessory proteins such as clathrin heavy chain and a component of ESCRT III indicate that AMSH is “deeply integrated as a hub protein within the MVB-sorting protein interaction network” ( xref )."
16702236
biogrid
No evidence text available
16431367
biogrid
No evidence text available
16431367
biogrid
No evidence text available
16716190
biogrid
No evidence text available
16716190
biogrid
No evidence text available
26496610
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
USP8 affects STAM
| 7
STAMBP binds USP8 and STAM. 5 / 5
| 5
sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
26918171
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
STAMBP affects SEPSECS
| 7
SEPSECS binds STAMBP. 7 / 7
| 7
sparser
"Moreover, the K63‐specific DUB AMSH‐LP was the most effective in hydrolysing polyubiquitin chains on phagosomes."
36281581
sparser
"USP14, for instance, has exo‐activity as it removes K48‐linked chains only from the distal end, producing exclusively mono‐ubiquitin moieties [ xref ]; whereas other DUBs including CYLD, USP9X, AMSH‐LP and A30 were shown to possess endo‐activity, cleaving longer ubiquitin chains from their substrates [ xref , xref ]."
25478702
sparser
"The oxyester bond linking maltoheptaose to the ubiquitin dimer or tetramer was hydroxylamine sensitive and could not be cleaved by the M1‐Ub‐specific deubiquitylase Otulin or the K63‐Ub‐specific deubiquitylase AMSH‐LP (Fig xref )."
35274759
sparser
"As a member of the JAMM family of DUBs, STAMBPL1 (also known as AMSH‐LP) specifically cleaves K63‐linked polyubiquitin on the substrates and plays a role in the regulation of mesenchymal phenotypes. [ xref , xref ] Consistently, in this study, STAMBPL1 was identified as a potential mesenchymal maintenance regulator in KIRC cells, whose silencing decreased mesenchymal markers level and induced immune response genes expression."
39527690
sparser
"Likewise, the closely related JAMM DUBs AMSH and AMSH‐LP (AMSH‐like protein) have been implicated as positive regulators in the bone morphogenetic protein (BMP) and TGFß responses respectively through their interaction with inhibitory I‐SMADs (61, 62)."
20073038
sparser
"Interestingly, the UbiCRest experiment showed that most ubiquitylation on the phagosome is removed by using the K63‐specific DUB AMSH‐LP."
36281581
sparser
"In these experiments, phagosomal extracts were treated with ubiquitin‐chain specific DUBs such as USP2 (unspecific), vOTU (unspecific), Otulin (specificity: M1/linear), Cezanne (specificity: K11> > K63), Trabid (specificity: K29, K33 > K63) or AMSH‐LP (specificity: K63) (Ritorto et al ,  xref ; Kristariyanto et al ,  xref ) and examined for the amount of monoubiquitin generated (Fig  xref )."
36281581
STAMBP affects Neoplasm Metastasis
| 4 3
STAMBP activates Neoplasm Metastasis. 7 / 7
| 4 3
eidos
"STAMBP promotes cell migration and invasion in vitro , and STAMBP knockdown suppresses tumor growth and metastasis in a xenograft mouse model ."
34102455
eidos
"Importantly , STAMBP knockdown suppressed LUAD tumor growth and metastasis by regulating the EGFR-mediated ERK activation in a xenograft mouse model ."
34102455
reach
"STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR and MAPK signaling pathway."
34102455
reach
"STAMBP suppression strongly inhibits melanoma metastasis in vivo ."
30454887
reach
"Thus, overexpression of STAMBP may promote cancer cell metastasis."
31795200
eidos
"STAMBP knockdown suppresses tumor growth and metastasis in vivo To assess the effect of STAMBP on tumor growth and metastasis in vivo , we established A549 cells with stable STAMBP knockdown by lentivirus-mediated shRNA expression ."
34102455
eidos
"STAMBP knockdown suppresses tumor growth and metastasis in vivo ."
34102455
STAM affects USP8
| 7
STAMBP binds USP8 and STAM. 5 / 5
| 5
sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
26918171
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
SEPSECS affects STAMBP
| 7
SEPSECS binds STAMBP. 7 / 7
| 7
sparser
"Moreover, the K63‐specific DUB AMSH‐LP was the most effective in hydrolysing polyubiquitin chains on phagosomes."
36281581
sparser
"USP14, for instance, has exo‐activity as it removes K48‐linked chains only from the distal end, producing exclusively mono‐ubiquitin moieties [ xref ]; whereas other DUBs including CYLD, USP9X, AMSH‐LP and A30 were shown to possess endo‐activity, cleaving longer ubiquitin chains from their substrates [ xref , xref ]."
25478702
sparser
"The oxyester bond linking maltoheptaose to the ubiquitin dimer or tetramer was hydroxylamine sensitive and could not be cleaved by the M1‐Ub‐specific deubiquitylase Otulin or the K63‐Ub‐specific deubiquitylase AMSH‐LP (Fig xref )."
35274759
sparser
"As a member of the JAMM family of DUBs, STAMBPL1 (also known as AMSH‐LP) specifically cleaves K63‐linked polyubiquitin on the substrates and plays a role in the regulation of mesenchymal phenotypes. [ xref , xref ] Consistently, in this study, STAMBPL1 was identified as a potential mesenchymal maintenance regulator in KIRC cells, whose silencing decreased mesenchymal markers level and induced immune response genes expression."
39527690
sparser
"Likewise, the closely related JAMM DUBs AMSH and AMSH‐LP (AMSH‐like protein) have been implicated as positive regulators in the bone morphogenetic protein (BMP) and TGFß responses respectively through their interaction with inhibitory I‐SMADs (61, 62)."
20073038
sparser
"Interestingly, the UbiCRest experiment showed that most ubiquitylation on the phagosome is removed by using the K63‐specific DUB AMSH‐LP."
36281581
sparser
"In these experiments, phagosomal extracts were treated with ubiquitin‐chain specific DUBs such as USP2 (unspecific), vOTU (unspecific), Otulin (specificity: M1/linear), Cezanne (specificity: K11> > K63), Trabid (specificity: K29, K33 > K63) or AMSH‐LP (specificity: K63) (Ritorto et al ,  xref ; Kristariyanto et al ,  xref ) and examined for the amount of monoubiquitin generated (Fig  xref )."
36281581
STAMBP affects cell migration
| 1 5
STAMBP activates cell migration. 6 / 6
| 1 5
reach
"STAMBP overexpression promoted cell migration and invasion, whereas STAMBP knockdown attenuated these processes in LUAD cells after epidermal growth factor treatment."
34102455
reach
"Cell migration and invasive abilities were significantly blocked by knockdown of STAMBP (siSTAMBP-1 and siSTAMBP-2) in FaDu and SAS cells (Figure 6D,E)."
31795200
reach
"A recent study showed that STAMBP expression contributes to melanoma cell migration and invasion through the stabilization of SLUG expression [53]."
31795200
reach
"While the cell viabilities of both UACC257 and SK-MEL-28 cell lines were not affected ( Fig. 1 B), the cell migration ( Fig. 1 C) and invasion ( Fig. 1 D) of both cell lines were suppressed by STAMBP [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30454887
reach
"Overexpression of STAMBP released RAI14 knockdown-induced inhibition of cell proliferation (Supplementary Fig. 3b), cell migration (Supplementary Fig. 3c) and cell invasion (Supplementary Fig. 3d)."
36434041
eidos
"STAMBP promotes cell migration and invasion in vitro , and STAMBP knockdown suppresses tumor growth and metastasis in a xenograft mouse model ."
34102455
STAMBP affects MC1R
| 2 4
STAMBP activates MC1R.
| 4
STAMBP activates MC1R. 4 / 4
| 4
sparser
"ACTH (1–39) or α-MSH can activate MC1R, MC3R, MC4R, and MC5R ( xref ), but MC2R can only be activated by ACTH and not by α-MSH or other analogs ( xref )."
28228747
sparser
"Activation of MC1R by α-MSH or ACTH increases cAMP synthesis which indirectly induces a switch from the production of pheomelanin to eumelanin synthesis [ xref ] ( xref )."
27428965
sparser
"The activation of MC1R by its ligand α-MSH or adrenocorticotropic hormone (ACTH) leads to an increase in adenylyl cyclase, which in turn upregulates intracellular cAMP levels [ xref , xref ]."
28241436
sparser
"ACTH can activate all five receptor subtypes; of the melanocortins, only ACTH activates MC2R; ACTH as well as α-MSH, β-MSH and γ-MSH activate MC1R, MC3R, MC4R and MC5R, although with varying affinities."
28805746
STAMBP binds MC1R.
| 2
STAMBP binds MC1R. 2 / 2
| 2
reach
"[5] a-Melanocyte stimulating hormone (a-MSH), which binds to MSH-R, a G protein coupled receptor also known as the melanocortin-1 receptor (MC1-R) [6] activates AC, thereby increasing the amount of cAMP in the cell."
12503631
reach
"Binding of aMSH to MC1R may be functionally protective against UV-induced DNA damage as aMSH pretreatment of melanocytes can reduce generation of UV-induced oxidative byproducts, an effect that was absent in melanocytes expressing loss-of-function MC1R, suggesting the mechanism mediating this susceptibility may be independent of pigmentation."
37790306
STAMBP affects GJA1
2 1 | 1 2
STAMBP binds GJA1.
2 | 2
GJA1 binds STAMBP. 4 / 4
2 | 2
biogrid
No evidence text available
25070368
sparser
"AMSH forms a complex with Cx43, and overexpression of a catalytically inactive form of AMSH leads to accumulation of Cx43 modified with lysine 63-linked ubiquitin chains, indicating that AMSH catalyze[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26855059
biogrid
No evidence text available
25070368
sparser
"In this study, we demonstrate that Cx43 is modified with lysine 63-linked polyubiquitin chains and that these increase the interaction between Cx43 and AMSH."
25070368
STAMBP inhibits GJA1.
| 1
STAMBP inhibits GJA1. 1 / 1
| 1
reach
"AMSH is also recruited to GAP junction plaque sites and negatively regulates the turnover of the GAP junction protein Connexin 43 49."
28064438
STAMBP deubiquitinates GJA1.
1 |
STAMBP deubiquitinates GJA1. 1 / 1
1 |
ubibrowser
"<span class="match term0">AMSH</span>-mediated deubiquitination of <span class="match term1">Cx43</span> regulates internalization and degradation of gap junctions"
25070368
STAMBP affects GCGR
1 | 3 2
STAMBP binds GCGR.
1 | 1 2
GCGR binds STAMBP. 4 / 4
1 | 1 2
sparser
"We therefore assessed whether STAMBP can bind the GCGR and whether STAMBP knockdown alters GCGR ubiquitination status."
32967969
sparser
"As shown in xref ( A and B ), STAMBP associates with the GCGR, and the interaction is significantly increased after agonist stimulation for 15 min."
32967969
reach
"We therefore assessed whether STAMBP can bind the GCGR and whether STAMBP knockdown alters GCGR ubiquitination status."
32967969
biogrid
No evidence text available
32967969
STAMBP deubiquitinates GCGR.
| 1
STAMBP deubiquitinates GCGR. 1 / 1
| 1
reach
"Therefore, deubiquitination of the GCGR by STAMBP after acute exposure to glucagon may not critically influence GCGR trafficking to the lysosomes."
32967969
STAMBP activates GCGR.
| 1
STAMBP activates GCGR. 1 / 1
| 1
reach
"Overall, these data strongly suggest that both STAMBP and USP33 deubiquitinate agonist-activated GCGR, whereas the basal ubiquitination of GCGR is governed only by USP33 activity."
32967969
Snf7 affects STAMBP
| 5
STAMBP binds snf7. 4 / 4
| 4
sparser
"Thus, both clathrin and AMSH are deeply embedded within the protein interaction network associated with MVB sorting, and AMSH can simultaneously interact with both ESCRT-0 and ESCRT-III components [31[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16996268
sparser
"The JAMM member, AMSH, is implicated in regulating EGFR de-ubiquitination on endosomes [ xref ]; furthermore, AMSH interacts with components of the ESCRT-III complex [ xref ]."
29543760
sparser
"AMSH also binds the ESCRT-III subunits CHMP1A, CHMP1B, and CHMP2A [7] ."
21531206
sparser
"Binding of AMSH to the ESCRT-III components is essential for targeting of AMSH to endosomes [42] ."
22800866
STAMBP binds STAM and snf7. 1 / 1
| 1
sparser
"Recent studies showed that AMSH binds to the ESCRT-III complex in a STAM-independent manner ( xref ; xref ), in support of the suggestion that AMSH might be a counterpart of Doa4p ( xref )."
17660439
STAMBP affects ULK1
4 | 1
STAMBP binds ULK1.
4 |
STAMBP binds ULK1. 4 / 4
4 |
biogrid
No evidence text available
32453962
biogrid
No evidence text available
32453962
biogrid
No evidence text available
32453962
biogrid
No evidence text available
32453962
STAMBP activates ULK1.
| 1
STAMBP activates ULK1. 1 / 1
| 1
reach
"STAMBP may promote the stabilization of Unc-51-like autophagy-activating kinase 1 (ULK1) by removing its K48-linked ubiquitin chains, thereby participating in the regulation of autophagic flux ."
36434041
STAMBP affects MC4R
| 1 4
STAMBP activates MC4R.
| 1 2
STAMBP activates MC4R. 3 / 3
| 1 2
sparser
"ACTH (1–39) or α-MSH can activate MC1R, MC3R, MC4R, and MC5R ( xref ), but MC2R can only be activated by ACTH and not by α-MSH or other analogs ( xref )."
28228747
reach
"Of interest, if synaptic plasticity is the primary means by which aMSH activates PVH MC4R neurons and causes satiety, then it would explain why alphaMSH and MC4R signaling is so necessary on the one hand, and why alphaMSH release by ARC POMC neurons is generally so insufficient on the other hand."
28817798
sparser
"ACTH can activate all five receptor subtypes; of the melanocortins, only ACTH activates MC2R; ACTH as well as α-MSH, β-MSH and γ-MSH activate MC1R, MC3R, MC4R and MC5R, although with varying affinities."
28805746
STAMBP binds MC4R.
| 2
STAMBP binds MC4R. 2 / 2
| 2
sparser
"By comparison, α–MSH bound to MC4R with a 4.5-fold higher affinity (K d = 11.93 ± 1.23 nM) than LCN2 and competed for binding with LCN2 with aK i of 12.63 ± 1.10 nM ( xref and xref )."
28273060
sparser
"Together with inhibiting the activity of the POMC/CART neurons through a GABAergic effect (Pu et al., xref ), they release AgRP, a characterized anabolic peptide able to competitively inhibit α–MSH binding to the MC4R (Ollmann et al., xref )."
28690493
STAMBP affects FH
| 5
STAMBP binds FH. 5 / 5
| 5
sparser
"FH-STAMBP but not FH-STAMBP (D348A) may cleave polyubiquitination chain from EGFR ( xref D)."
34102455
sparser
"We transiently transfected the control and FH-STAMBP (D348A) constructs into H1299 cells to assess EGFR protein stability upon CHX treatment."
34102455
sparser
"The results showed that EGFR stability did not change when FH-STAMBP (D348A) was overexpressed in these cells ( xref G), suggesting catalytic activity of STAMBP is crucial in maintaining EGFR protein stability."
34102455
sparser
"The results demonstrated that overexpression of FH-STAMBP decreased EGFR polyubiquitination ( xref B) whereas STAMBP knockdown promoted EGFR polyubiquitination upon EGF treatment ( xref C)."
34102455
sparser
"We also performed in vitro deubiquitination assay by incubating EGFR complex with purified FH-STAMBP or FH-STAMBP (D348A) in a deubiquitination reaction."
34102455
STAMBP affects CHMP4B
3 1 | 1
STAMBP binds CHMP4B. 4 / 4
3 1 |
biogrid
No evidence text available
16730941
biogrid
No evidence text available
17711858
biogrid
No evidence text available
16730941
hprd
No evidence text available
16730941
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
STAMBP affects CASR
2 | 1 2
STAMBP binds CASR.
2 | 2
CASR binds STAMBP. 4 / 4
2 | 2
sparser
"To assess in mammalian cells the interaction between AMSH and CaR carboxyl terminus, HEK-293 cells were transfected with plasmids coding for CaR carboxyl terminus fused to GST and Myc-tagged AMSH."
16854379
sparser
"Fig. 1 A illustrates the interaction between CaR and AMSH-1; the full sequence of AMSH-1 and the partial sequence of the yeast two-hybrid prey are indicated."
16854379
biogrid
No evidence text available
16854379
biogrid
No evidence text available
16854379
STAMBP increases the amount of CASR.
| 1
Modified STAMBP increases the amount of CASR. 1 / 1
| 1
reach
"Although expression of AMSH would be expected to increase CaR protein expression, it had the opposite effect [XREF_BIBR]."
17979874
STAM affects STAMBP, and USP8
| 5
STAMBP binds USP8 and STAM. 5 / 5
| 5
sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
26918171
FH affects STAMBP
| 5
STAMBP binds FH. 5 / 5
| 5
sparser
"FH-STAMBP but not FH-STAMBP (D348A) may cleave polyubiquitination chain from EGFR ( xref D)."
34102455
sparser
"We transiently transfected the control and FH-STAMBP (D348A) constructs into H1299 cells to assess EGFR protein stability upon CHX treatment."
34102455
sparser
"The results showed that EGFR stability did not change when FH-STAMBP (D348A) was overexpressed in these cells ( xref G), suggesting catalytic activity of STAMBP is crucial in maintaining EGFR protein stability."
34102455
sparser
"The results demonstrated that overexpression of FH-STAMBP decreased EGFR polyubiquitination ( xref B) whereas STAMBP knockdown promoted EGFR polyubiquitination upon EGF treatment ( xref C)."
34102455
sparser
"We also performed in vitro deubiquitination assay by incubating EGFR complex with purified FH-STAMBP or FH-STAMBP (D348A) in a deubiquitination reaction."
34102455
CHMP4B affects STAMBP
3 1 | 1
STAMBP binds CHMP4B. 4 / 4
3 1 |
biogrid
No evidence text available
16730941
biogrid
No evidence text available
17711858
biogrid
No evidence text available
16730941
hprd
No evidence text available
16730941
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
ULK1 affects STAMBP
4 |
STAMBP binds ULK1. 4 / 4
4 |
biogrid
No evidence text available
32453962
biogrid
No evidence text available
32453962
biogrid
No evidence text available
32453962
biogrid
No evidence text available
32453962
TCHH affects STAMBP
| 2 2
TCHH inhibits STAMBP. 4 / 4
| 2 2
reach
"In addition, THL could inhibit the JAMM protease family AMSH, which cleaves K63 linked ubiquitin chains of endosomal proteins XREF_BIBR, XREF_BIBR."
28459440
reach
"AMSH was inhibited by THL with an IC 50 that was ~ 8-fold higher (4 muM) than that measured for Rpn11, and inhibition was reversible by Zn (cyclen) 2+ (XREF_FIG)."
28459440
sparser
"In addition, THL could inhibit the JAMM protease family AMSH, which cleaves K63-linked ubiquitin chains of endosomal proteins xref , xref ."
28459440
sparser
"AMSH was inhibited by THL with an IC 50 that was ∼8-fold higher (4 μM) than that measured for Rpn11, and inhibition was reversible by Zn(cyclen) 2+ ( xref )."
28459440
STAMBP affects stabilization
| 4
STAMBP activates stabilization. 4 / 4
| 4
eidos
"STAMBP promotes EGFR stabilization ."
34102455
eidos
"The results demonstrated that increased STAMBP expression promoted EGFR stabilization , whereas decreased STAMBP expression accelerated EGFR degradation ( Fig. 2H and I ) ."
34102455
eidos
"We found that STAMBP is overexpressed in NSCLC and promotes EGFR stabilization in vitro and in xenograft tissues ."
34102455
eidos
"STAMBP promotes EGFR stabilization Although a previous report indicated that STAMBP promotes the stabilization of EGFR by deubiquitinating and recycling EGFR to the cell membrane [ 10 ] , subsequent studies revealed that STAMBP contributes to EGFR degradation by deubiquitinating the cargo in MVB / late endosomes [ 19,30,31 ] ."
34102455
STAMBP inhibits inflammatory response. 3 / 3
| 3
reach
"The enzymes SIRT2 and STAMBP, which were also highest in sample cluster 1, suppress inflammation and have anti-inflammatory effects [40, 41]."
37516841
reach
"It has been discovered that STAMBP knockdown leads directly to an elevated inflammatory response upon TLR activation."
37300757
reach
"The neuropeptide aMSH, a potent modulator of fever and inflammation, can act at the central level to inhibit inflammation in peripheral tissues (7)."
9252244
STAMBP activates inflammatory response.
| 1
STAMBP activates inflammatory response. 1 / 1
| 1
reach
"However, STAMBP and SIRT2 may promote IL-18 and inflammatory response through the inflammasomes NALP7 and NLRP3."
37293545
STAMBP affects SMAD7
2 1 |
STAMBP binds SMAD7. 3 / 4
2 1 |
biogrid
No evidence text available
11483516
hprd
No evidence text available
11483516
biogrid
No evidence text available
11483516
STAMBP affects PIK3C2A
4 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
STAMBP affects Neoplasms
| 4
STAMBP activates Neoplasms. 4 / 4
| 4
reach
"The results of these two-way interventions provide strong evidence supporting the tumor-promoting effect of STAMBP in TNBC."
36434041
reach
"STAMBP has been reported to promote tumor progression [18]."
40180620
reach
"The recent studies validated these hypotheses: WWP1-induced EGFR ubiquitination was found to be a decisive signal for EGFR recycling (30); meanwhile, the overexpression of STAMBP can promote the stabilization of EGFR, and promote tumor progression (31)."
34669962
reach
"Similar to the protumor effect of RAI14 in vitro, the overexpression of RAI14 reversed the xenograft tumor reduction caused by the knockdown of STAMBP to a certain extent (Fig. 6a–c)."
36434041
STAMBP affects HGS
| 3 1
STAMBP binds HGS.
| 2 1
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
STAM binds HGS and STAMBP. 1 / 1
| 1
reach
"Thus, the STAM, Hrs, and AMSH complex may engage in a tripartite interaction with clathrin, embedding it within the endosomal coat structure.Hrs serves to recruit downstream components of the MVB sort[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
HGS binds STAMBP. 1 / 1
| 1
reach
"The mammalian Hrs and STAM complex, equivalent to the Vps27 and Hse1 complex in budding yeast, binds two deubiquitinating enzymes, the JAMM and MPN+ family member AMSH (associated molecule with the SH3 domain of STAM) and the ubiquitin specific protease family member UBPY (ubiquitin isopeptidase Y)."
17660439
STAMBP ubiquitinates HGS.
| 1
Modified STAMBP leads to the ubiquitination of HGS. 1 / 1
| 1
reach
"Depletion of AMSH by siRNA does not affect CXCR4 degradation, but expression of AMSH dominant negative constructs enhances HRS or STAM ubiquitination and inhibits CXCR4 degradation."
24790097
STAMBP affects F2RL1
1 | 3
STAMBP deubiquitinates F2RL1.
1 | 1
STAMBP leads to the deubiquitination of F2RL1. 2 / 2
1 | 1
ubibrowser
"Expression of the catalytically inactive mutants, <span class="match term0">AMSH</span>(D348A) and UBPY(C786S), caused an increase in <span class="match term1">PAR</span>(2) ubiquitination and trapped the receptor in early endosomes, thereby preventing lysosomal trafficking and degradation."
19684015
reach
"USP8 and AMSH mediate deubiquitination of PAR2 and its sorting from endosomes to lysosomes [XREF_BIBR]."
28448471
STAMBP ubiquitinates F2RL1.
| 1
STAMBP ubiquitinates F2RL1. 1 / 1
| 1
reach
"24 USP8 or AMSH knockdown by siRNA results in somewhat greater ubiquitination of PAR2, suggesting that these DUBs regulate PAR2 deubiquitination."
26055053
STAMBP inhibits F2RL1.
| 1
STAMBP inhibits F2RL1. 1 / 1
| 1
reach
"24 Deubiquitination may be necessary to efficiently target PAR2 to lysosomes because USP8 or AMSH knockdown moderately attenuated PAR2 degradation."
26055053
STAMBP affects ESCRT-0
| 4
STAMBP binds ESCRT-0.
| 3
STAMBP binds ESCRT-0. 3 / 3
| 3
reach
"Recruitment of AMSH towards ESCRT-0 is essential for deubiquitination of STAM and Hrs, but this deubiquitination does not alter their stability."
22800866
reach
"The ESCRT-0/AMSH interaction is achieved through the binding of the SH3 domain of STAM with the SH3 binding motif (SBM) of AMSH [5,18] , while the charged multivesicular body proteins (CHMPs) of ESCRT[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
reach
"AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4."
20159979
STAMBP activates ESCRT-0.
| 1
STAMBP activates ESCRT-0. 1 / 1
| 1
reach
"71 In contrast to PAR2, USP8 (or AMSH) does not impact CXCR4 ubiquitination but instead modulates the ubiquitin status of ESCRT-0 that is ubiquitinated by the E3 ligase AIP4, 23 reinforcing the idea that ubiquitination of the transport machinery represents an important regulatory event in GPCR trafficking."
26055053
STAMBP affects E2F1
| 4
STAMBP binds E2F1. 4 / 4
| 4
sparser
"This finding was supported by the following observations: first, STAMBP directly bound to E2F1 in PC cells."
39242557
sparser
"Co-IP assays utilizing endogenous E2F1 and STAMBP antibodies in BxPC-3 and SW1990 cells verified the interaction between E2F1 and STAMBP (Fig. xref )."
39242557
sparser
"Additionally, Docking analysis indicated a binding interaction between E2F1 and STAMBP (Fig. xref )."
39242557
sparser
"To test this hypothesis, we first investigated whether STAMBP interacts with E2F1 in PC cells."
39242557
STAMBP affects CXCR4
| 3
STAMBP inhibits CXCR4.
| 1
STAMBP inhibits CXCR4. 1 / 2
| 1
reach
"We also examined the role of AMSH on agonist promoted degradation of CXCR4."
20505072
STAMBP ubiquitinates CXCR4.
| 1
STAMBP leads to the ubiquitination of CXCR4. 1 / 1
| 1
reach
"Ubiquitination of CXCR4 is not directly modulated by STAMBP."
33253913
STAMBP decreases the amount of CXCR4.
| 1
STAMBP decreases the amount of CXCR4. 1 / 1
| 1
reach
"AMSH depletion or overexpression of dominant negative (DN) AMSH results in the accumulation of ubiquitylated forms of the ESCRT 0 proteins STAM and Hrs and increased steady-state levels of CXCR4 in different human cell lines."
25396681
SMAD7 affects STAMBP
2 1 |
STAMBP binds SMAD7. 3 / 4
2 1 |
biogrid
No evidence text available
11483516
hprd
No evidence text available
11483516
biogrid
No evidence text available
11483516
PIK3C2A affects STAMBP
4 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
GJA1 affects STAMBP
2 | 2
GJA1 binds STAMBP. 4 / 4
2 | 2
biogrid
No evidence text available
25070368
sparser
"AMSH forms a complex with Cx43, and overexpression of a catalytically inactive form of AMSH leads to accumulation of Cx43 modified with lysine 63-linked ubiquitin chains, indicating that AMSH catalyze[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26855059
biogrid
No evidence text available
25070368
sparser
"In this study, we demonstrate that Cx43 is modified with lysine 63-linked polyubiquitin chains and that these increase the interaction between Cx43 and AMSH."
25070368
GCGR affects STAMBP
1 | 1 2
GCGR binds STAMBP. 4 / 4
1 | 1 2
sparser
"We therefore assessed whether STAMBP can bind the GCGR and whether STAMBP knockdown alters GCGR ubiquitination status."
32967969
sparser
"As shown in xref ( A and B ), STAMBP associates with the GCGR, and the interaction is significantly increased after agonist stimulation for 15 min."
32967969
reach
"We therefore assessed whether STAMBP can bind the GCGR and whether STAMBP knockdown alters GCGR ubiquitination status."
32967969
biogrid
No evidence text available
32967969
EGFR affects STAMBP
1 | 1 2
EGFR binds STAMBP.
1 | 2
STAMBP binds EGFR. 3 / 3
1 | 2
sparser
"Our data also indicate a functionally significant association of AMSH with endosomes that influences the rate of EGF receptor (EGFR) degradation."
15314065
biogrid
No evidence text available
34102455
sparser
"To provide mechanical insight into STAMBP-mediated EGFR protein stabilization in LUAD cells, we assessed whether STAMBP can bind directly to EGFR."
34102455
EGFR activates STAMBP.
| 1
EGFR activates STAMBP. 1 / 1
| 1
reach
"Small molecule inhibitors of EGFR and MAPK signaling pathway may block STAMBP induced cell mobility and invasion as well as ERK activation in cells."
34102455
E2F1 affects STAMBP
| 4
STAMBP binds E2F1. 4 / 4
| 4
sparser
"This finding was supported by the following observations: first, STAMBP directly bound to E2F1 in PC cells."
39242557
sparser
"Co-IP assays utilizing endogenous E2F1 and STAMBP antibodies in BxPC-3 and SW1990 cells verified the interaction between E2F1 and STAMBP (Fig. xref )."
39242557
sparser
"Additionally, Docking analysis indicated a binding interaction between E2F1 and STAMBP (Fig. xref )."
39242557
sparser
"To test this hypothesis, we first investigated whether STAMBP interacts with E2F1 in PC cells."
39242557
CASR affects STAMBP
2 | 2
CASR binds STAMBP. 4 / 4
2 | 2
sparser
"To assess in mammalian cells the interaction between AMSH and CaR carboxyl terminus, HEK-293 cells were transfected with plasmids coding for CaR carboxyl terminus fused to GST and Myc-tagged AMSH."
16854379
sparser
"Fig. 1 A illustrates the interaction between CaR and AMSH-1; the full sequence of AMSH-1 and the partial sequence of the yeast two-hybrid prey are indicated."
16854379
biogrid
No evidence text available
16854379
biogrid
No evidence text available
16854379
Rep affects STAMBP
3 |
Rep binds STAMBP. 3 / 3
3 |
biogrid
No evidence text available
34597346
biogrid
No evidence text available
34597346
biogrid
No evidence text available
34597346
Bisphenol A affects STAMBP
3 |
Bisphenol A decreases the amount of STAMBP.
2 |
Bisphenol A decreases the amount of STAMBP. 2 / 2
2 |
ctd
No evidence text available
36041667
ctd
No evidence text available
33376534
Bisphenol A increases the amount of STAMBP.
1 |
Bisphenol A increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
25181051
VPS4A affects STAMBP
| 1 2
STAMBP binds CHMP3 and VPS4A. 2 / 2
| 2
sparser
"The MIM 1 sequence motif responsible for VPS4 interaction [ xref ] overlaps with the CHMP3-AMSH binding site and superpositioning of the VPS4A-CHMP1B and VPS4B-CHMP2A structures with AMSH-CHMP3 demonstrates the overlap of the binding motifs, which prohibits simultaneous binding of AMSH and VPS4 to CHMP3."
21827950
sparser
"Furthermore the AMSH binding site overlaps with the VPS4 site on CHMP3 ( xref ) [ xref , xref ], consistent with the finding that AMSH CHMP3 and VPS4 binding are exclusive (data not shown)."
21827950
STAMBP binds VPS4A. 1 / 1
| 1
reach
"The MIM 1 sequence motif responsible for VPS4 interaction [XREF_BIBR] overlaps with the CHMP3-AMSH binding site and superpositioning of the VPS4A-CHMP1B and VPS4B-CHMP2A structures with AMSH-CHMP3 demonstrates the overlap of the binding motifs, which prohibits simultaneous binding of AMSH and VPS4 to CHMP3."
21827950
UBD affects STAMBP
| 1 1
UBD binds STAMBP. 1 / 2
| 1
sparser
"This places the Rpn11 deubiquitylase over the mouth of the ATPases, and superposition with a structure of the homologous AMSH enzyme bound with diubiquitin ( xref ) supports the model that Rpn11 removes ubiquitin as substrate enters the ATPase channel."
23414347
STAMBP binds UBD and I44. 1 / 1
| 1
reach
"Inspection of our structural model representing AMSH and diubiquitin complex reveals that the I44 patch of the distal ubiquitin is satisfied, with the Ile44 residue engaged in van der Waals interaction with Phe320; however, Ile44 of the proximal ubiquitin is unoccupied (XREF_SUPPLEMENTARY)."
24151880
STAMBP affects tumor growth
| 3
STAMBP activates tumor growth. 3 / 3
| 3
eidos
"STAMBP knockdown suppresses tumor growth and metastasis in vivo ."
34102455
eidos
"STAMBP knockdown suppresses tumor growth and metastasis in vivo To assess the effect of STAMBP on tumor growth and metastasis in vivo , we established A549 cells with stable STAMBP knockdown by lentivirus-mediated shRNA expression ."
34102455
eidos
"STAMBP promotes cell migration and invasion in vitro , and STAMBP knockdown suppresses tumor growth and metastasis in a xenograft mouse model ."
34102455
STAMBP affects rep
3 |
Rep binds STAMBP. 3 / 3
3 |
biogrid
No evidence text available
34597346
biogrid
No evidence text available
34597346
biogrid
No evidence text available
34597346
STAMBP affects production
| 3
STAMBP inhibits production. 3 / 3
| 3
sparser
"TGF-β2, α-MSH, CGRP, or PEDF do not inhibit NO production by Mϕs."
23241881
sparser
"Indeed, we found that the IC 50s for ACTH [3.2 nM] and α-MSH [36 nM] that inhibit leptin production are much higher than the levels circulating in blood under basal conditions, and the concentrations[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12644303
sparser
"Regarding the role of DUBs in HIV-1 replication, it has been shown that the ESCRT-III interacting DUB AMSH (associated molecule with the SH3 domain of STAM) can inhibit viral particle production, while AMSH knockdown did not influence virus release [ xref ]."
28805676
STAMBP affects VPS4A
| 1 2
STAMBP binds CHMP3 and VPS4A. 2 / 2
| 2
sparser
"The MIM 1 sequence motif responsible for VPS4 interaction [ xref ] overlaps with the CHMP3-AMSH binding site and superpositioning of the VPS4A-CHMP1B and VPS4B-CHMP2A structures with AMSH-CHMP3 demonstrates the overlap of the binding motifs, which prohibits simultaneous binding of AMSH and VPS4 to CHMP3."
21827950
sparser
"Furthermore the AMSH binding site overlaps with the VPS4 site on CHMP3 ( xref ) [ xref , xref ], consistent with the finding that AMSH CHMP3 and VPS4 binding are exclusive (data not shown)."
21827950
STAMBP binds VPS4A. 1 / 1
| 1
reach
"The MIM 1 sequence motif responsible for VPS4 interaction [XREF_BIBR] overlaps with the CHMP3-AMSH binding site and superpositioning of the VPS4A-CHMP1B and VPS4B-CHMP2A structures with AMSH-CHMP3 demonstrates the overlap of the binding motifs, which prohibits simultaneous binding of AMSH and VPS4 to CHMP3."
21827950
STAMBP affects UBD
| 1 1
UBD binds STAMBP. 1 / 2
| 1
sparser
"This places the Rpn11 deubiquitylase over the mouth of the ATPases, and superposition with a structure of the homologous AMSH enzyme bound with diubiquitin ( xref ) supports the model that Rpn11 removes ubiquitin as substrate enters the ATPase channel."
23414347
STAMBP binds UBD and I44. 1 / 1
| 1
reach
"Inspection of our structural model representing AMSH and diubiquitin complex reveals that the I44 patch of the distal ubiquitin is satisfied, with the Ile44 residue engaged in van der Waals interaction with Phe320; however, Ile44 of the proximal ubiquitin is unoccupied (XREF_SUPPLEMENTARY)."
24151880
STAMBP affects SH3 domain
| 3
STAMBP binds STAM and SH3 domain. 3 / 3
| 3
reach
"To probe this, we used a combination of biophysical techniques and biochemical assays to assess three individual events : (1) AMSH recruitment to STAM via the SH3 domain and a longer STAM segment in which the UIM is fused to the SH3 domain (UIM-SH3), (2) ubiquitin binding to UIM-SH3, and finally, (3) the ternary complex of the catalytic domain of AMSH, UIM-SH3, and Lys63 linked diubiquitin."
24151880
reach
"We determined that the SH3 domain of STAM binds the catalytic domain of AMSH (AMSH219 E280A) with a K D of 1.4 +/- 0.04 microM (XREF_TABLE and XREF_SUPPLEMENTARY)."
24151880
reach
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner."
16702236
STAMBP affects PDPK1
| 1 2
STAMBP binds PDPK1.
| 2
STAMBP binds PDPK1. 2 / 2
| 2
sparser
"However, co-immunoprecipitation (Co-IP) revealed no direct interaction between STAMBP and PDK1 (Fig. xref and Supplementary Fig. xref )."
39242557
sparser
"To further elucidate the mechanism by which STAMBP modulates STAMBP expression in PC cells, we investigated whether there are direct interactions between STAMBP and PDK1."
39242557
STAMBP increases the amount of PDPK1.
| 1
STAMBP increases the amount of PDPK1. 1 / 1
| 1
reach
"STAMBP knockdown decreased PDK1 levels, an essential regulator of the aerobic glycolytic process, in several cancers."
39242557
STAMBP affects OTUB1
2 | 1
OTUB1 binds STAMBP. 3 / 3
2 | 1
sparser
"Our redesigned forms of K48-specific OTUB1 and K63-specific AMSH are highly active and have proven to be useful for this purpose."
25752577
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
STAMBP affects MC3R
| 1 2
STAMBP activates MC3R. 3 / 3
| 1 2
sparser
"ACTH can activate all five receptor subtypes; of the melanocortins, only ACTH activates MC2R; ACTH as well as α-MSH, β-MSH and γ-MSH activate MC1R, MC3R, MC4R and MC5R, although with varying affinities."
28805746
reach
"MC3R signaling is bi-directionally regulated by the endogenous melanocortin receptor agonist aMSH (produced by the POMC peptide in POMC neurons) which stimulates MC3R, and the endogenous MC3R antagonist AgRP, which inhibits the MC3R."
38712101
sparser
"ACTH (1–39) or α-MSH can activate MC1R, MC3R, MC4R, and MC5R ( xref ), but MC2R can only be activated by ACTH and not by α-MSH or other analogs ( xref )."
28228747
STAMBP affects MAPK
| 3
STAMBP activates MAPK.
| 2
STAMBP activates MAPK. 2 / 2
| 2
reach
"The overexpression of STAMBP triggered the activation of MAPK signaling after epidermal growth factor treatment."
34102455
reach
"STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR and MAPK signaling pathway."
34102455
STAMBP deubiquitinates MAPK.
| 1
STAMBP deubiquitinates MAPK. 1 / 1
| 1
reach
"Besides, STAMBP can deubiquitinate epidermal growth factor receptor (EGFR) and trigger mitogen-activated protein kinase signaling by increasing EGFR stability to promote lung adenocarcinoma metastasis [36]."
40180620
STAMBP affects GTSE1
3 |
GTSE1 binds STAMBP. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
biogrid
No evidence text available
33961781
STAMBP affects GAK
3 |
STAMBP binds GAK. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
STAMBP affects ESR1
| 3
STAMBP binds ESR1. 3 / 3
| 3
sparser
"An endogenous IP assay demonstrated that STAMBP could interact with ERα in ER-positive BRCA cells ( xref K)."
41301420
sparser
"STAMBP could directly bind to ERα protein and decrease the K48-linked ubiquitination levels of ERα protein, which might contribute to the progression and tamoxifen resistance of BRCA cells."
41301420
sparser
"Further investigation revealed that STAMBP binds to ERα and enhances its stability through deubiquitination, thereby promoting the progression of BRCA cells."
41301420
STAMBP affects Chemokine
| 3
STAMBP inhibits Chemokine.
| 1
STAMBP inhibits Chemokine. 1 / 1
| 1
reach
"3.1 STAMBP knockout increases innate immune cytokine and chemokine expression.."
33253913
STAMBP increases the amount of Chemokine.
| 1
STAMBP increases the amount of Chemokine. 1 / 1
| 1
reach
"NLRP3 inflammasomes have been regulated by STAMBP, a deubiquitinase STAM-binding protein identified by Joseph S et al. [125] upon contact with Toll-like receptor agonists or bacterial lipopolysaccharide (LPS), STAMBP knockdown by CRISPR/Cas9 gene editing increase the expression of many cytokines and chemokines [126]."
37300757
STAMBP decreases the amount of Chemokine.
| 1
STAMBP decreases the amount of Chemokine. 1 / 1
| 1
reach
"In a monocyte cell line, genetic knockout of STAMBP increases IL-1β secretion and increases subsequent IL-1β-driven cytokine and chemokine gene expression."
33253913
STAMBP affects CLTCL1
3 |
STAMBP binds CLTCL1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
STAMBP affects CLINT1
3 |
STAMBP binds CLINT1. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBP affects CIMAP1C
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBP affects CDKL3
3 |
CDKL3 binds STAMBP. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
STAMBP affects AGRP
| 1 2
STAMBP binds AGRP.
| 2
AGRP binds STAMBP. 2 / 2
| 2
sparser
"The recruitment of β-arrestins and the consecutive internalization of the neural MCRS is observed following binding of either AgRP or α–MSH [ xref ]."
23680515
sparser
"When adherence to DASH and MDS was low, the obesity risk allele was associated with higher means of AgRP and α–MSH among women and men, respectively."
| PMC
STAMBP activates AGRP.
| 1
STAMBP activates AGRP. 1 / 1
| 1
reach
"MC3R signaling is bi-directionally regulated by the endogenous melanocortin receptor agonist aMSH (produced by the POMC peptide in POMC neurons) which stimulates MC3R, and the endogenous MC3R antagonist AgRP, which inhibits the MC3R."
38712101
STAM affects SH3 domain
| 3
STAMBP binds STAM and SH3 domain. 3 / 3
| 3
reach
"To probe this, we used a combination of biophysical techniques and biochemical assays to assess three individual events : (1) AMSH recruitment to STAM via the SH3 domain and a longer STAM segment in which the UIM is fused to the SH3 domain (UIM-SH3), (2) ubiquitin binding to UIM-SH3, and finally, (3) the ternary complex of the catalytic domain of AMSH, UIM-SH3, and Lys63 linked diubiquitin."
24151880
reach
"We determined that the SH3 domain of STAM binds the catalytic domain of AMSH (AMSH219 E280A) with a K D of 1.4 +/- 0.04 microM (XREF_TABLE and XREF_SUPPLEMENTARY)."
24151880
reach
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner."
16702236
STAM affects GRB2
| 3
STAMBP binds STAM and GRB2. 3 / 3
| 3
sparser
"The RXXK motif of AMSH interacts with the SH3 domains of the STAM and Grb2 families of adaptor proteins with high affinity."
20159979
sparser
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12–14] , we speculate that the neuronal cell death in the AMSH-deficient brain might be caused by the lack of interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"Whereas AMSH bound to both STAM1 and Grb2 ( Figs."
12810066
SH3 domain affects STAMBP
| 3
STAMBP binds STAM and SH3 domain. 3 / 3
| 3
reach
"To probe this, we used a combination of biophysical techniques and biochemical assays to assess three individual events : (1) AMSH recruitment to STAM via the SH3 domain and a longer STAM segment in which the UIM is fused to the SH3 domain (UIM-SH3), (2) ubiquitin binding to UIM-SH3, and finally, (3) the ternary complex of the catalytic domain of AMSH, UIM-SH3, and Lys63 linked diubiquitin."
24151880
reach
"We determined that the SH3 domain of STAM binds the catalytic domain of AMSH (AMSH219 E280A) with a K D of 1.4 +/- 0.04 microM (XREF_TABLE and XREF_SUPPLEMENTARY)."
24151880
reach
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner."
16702236
OTUB1 affects STAMBP
2 | 1
OTUB1 binds STAMBP. 3 / 3
2 | 1
sparser
"Our redesigned forms of K48-specific OTUB1 and K63-specific AMSH are highly active and have proven to be useful for this purpose."
25752577
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
NLRP3 affects STAMBP
2 | 1
STAMBP binds NLRP3. 3 / 3
2 | 1
biogrid
No evidence text available
33253913
sparser
"Collectively, these data support a functional relationship via physical association of NLRP3 with STAMBP, whereby STAMBP modulates NLRP3 polyubiquitination through its catalytic activity."
33253913
biogrid
No evidence text available
32003754
HGS affects STAMBP
| 2 1
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
STAM binds HGS and STAMBP. 1 / 1
| 1
reach
"Thus, the STAM, Hrs, and AMSH complex may engage in a tripartite interaction with clathrin, embedding it within the endosomal coat structure.Hrs serves to recruit downstream components of the MVB sort[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
HGS binds STAMBP. 1 / 1
| 1
reach
"The mammalian Hrs and STAM complex, equivalent to the Vps27 and Hse1 complex in budding yeast, binds two deubiquitinating enzymes, the JAMM and MPN+ family member AMSH (associated molecule with the SH3 domain of STAM) and the ubiquitin specific protease family member UBPY (ubiquitin isopeptidase Y)."
17660439
GTSE1 affects STAMBP
3 |
GTSE1 binds STAMBP. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
biogrid
No evidence text available
33961781
GRB2 affects STAM, and STAMBP
| 3
STAMBP binds STAM and GRB2. 3 / 3
| 3
sparser
"The RXXK motif of AMSH interacts with the SH3 domains of the STAM and Grb2 families of adaptor proteins with high affinity."
20159979
sparser
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12–14] , we speculate that the neuronal cell death in the AMSH-deficient brain might be caused by the lack of interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"Whereas AMSH bound to both STAM1 and Grb2 ( Figs."
12810066
GAK affects STAMBP
3 |
STAMBP binds GAK. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
ESR1 affects STAMBP
| 3
STAMBP binds ESR1. 3 / 3
| 3
sparser
"An endogenous IP assay demonstrated that STAMBP could interact with ERα in ER-positive BRCA cells ( xref K)."
41301420
sparser
"STAMBP could directly bind to ERα protein and decrease the K48-linked ubiquitination levels of ERα protein, which might contribute to the progression and tamoxifen resistance of BRCA cells."
41301420
sparser
"Further investigation revealed that STAMBP binds to ERα and enhances its stability through deubiquitination, thereby promoting the progression of BRCA cells."
41301420
ESCRT-0 affects STAMBP
| 3
STAMBP binds ESCRT-0. 3 / 3
| 3
reach
"Recruitment of AMSH towards ESCRT-0 is essential for deubiquitination of STAM and Hrs, but this deubiquitination does not alter their stability."
22800866
reach
"The ESCRT-0/AMSH interaction is achieved through the binding of the SH3 domain of STAM with the SH3 binding motif (SBM) of AMSH [5,18] , while the charged multivesicular body proteins (CHMPs) of ESCRT[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
reach
"AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4."
20159979
E3_Ub_ligase affects STAMBP
| 2 1
E3_Ub_ligase ubiquitinates STAMBP.
| 2
E3_Ub_ligase ubiquitinates STAMBP. 2 / 2
| 2
reach
"Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2."
14755250
reach
"Li and Seth [58] have demonstrated that AMSH itself is ubiquitinated by Smurf2, the E3 ligase that is responsible for TGF-β receptor and I-Smad ubiquitination and degradation."
16996268
E3_Ub_ligase binds STAMBP.
| 1
E3_Ub_ligase binds RNF19A and STAMBP. 1 / 1
| 1
sparser
"The degradation of the CaR is mediated by the ubiquitin system through interactions with the E3 ubiquitin ligase, dorfin and AMSH (Associated Molecule with the SH3 domain of STAM), a deubiqui-tinating enzyme [ xref ]."
17979874
CLTCL1 affects STAMBP
3 |
STAMBP binds CLTCL1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
CLINT1 affects STAMBP
3 |
STAMBP binds CLINT1. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
CIMAP1C affects STAMBP
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
CDKL3 affects STAMBP
3 |
CDKL3 binds STAMBP. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
2,3,7,8-tetrachlorodibenzodioxine increases the amount of STAMBP. 3 / 3
3 |
ctd
No evidence text available
33387578
ctd
No evidence text available
32109520
ctd
No evidence text available
17942748
Trimethylamine N-oxide increases the amount of STAMBP. 2 / 2
| 2
reach
"We found that TNF-α alone, but not TMAO, significantly increased the release of VEGFA, GDNF, CDCP1, OPG, AXIN1, FGF-5, HGF, 4E-BP1, CD40, CASP-8, TNFRSF9, NT-3, STAMBP compared to unstimulated cells (Fig. 6)."
38643262
reach
"We also found that the release of VEGFA, GDNF, CDCP1, OPG, uPA, AXIN1, FGF-5, MMP-1, MMP-10, PD-L1, HGF, Flt3L, 4E-BP1, DNER, CD40, CASP-8, ADA, TNFRSF9, NT-3, TWEAK and STAMBP were enhanced by the combination of TNF-α 50 ng/ml and TMAO compared to TNF-α 50 ng/ml alone (Fig. 6)."
38643262
Sodium fluoride affects STAMBP
2 |
Sodium fluoride increases the amount of STAMBP.
1 |
Sodium fluoride increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
27862939
Sodium fluoride decreases the amount of STAMBP.
1 |
Sodium fluoride decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
28918527
Phenobarbital affects STAMBP
2 |
Phenobarbital increases the amount of STAMBP.
1 |
Phenobarbital increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
19270015
Phenobarbital decreases the amount of STAMBP.
1 |
Phenobarbital decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
30047161
P8 affects STAMBP
| 2
P8 binds STAMBP. 2 / 2
| 2
sparser
"On the contrary, the mutation of K 238 by T 238 (AMSH-P8) has a drastic negative effect on the binding affinity of AMSH (see Table 1 )."
27725184
sparser
"It is also noticeable from our ensemble of titration experiments that the directions of the shifts on UIM-SH3 are similar to that of the complete set of peptides from AMSH-P1 to AMSH-P8."
27725184
P4 affects STAMBP
| 2
P4 binds STAMBP. 2 / 2
| 2
sparser
"In the light of these observations, it is likely that the P 239 residue of AMSH-P3 would be oriented in a direction close to the residues Trp246 and Glu224 of SH3, while 230 PP 231 of AMSH-P4 would po[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"To gain insight into the orientation of AMSH with respect to SH3, we used different AMSH peptide sequence containing either the P 239 (AMSH-P3) or the 230 PP 231 (AMSH-P4) motif."
27725184
P-chloromercuribenzoic acid decreases the amount of STAMBP. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
MVps24 affects STAMBP
| 2
STAMBP binds mVps24. 2 / 2
| 2
reach
"We wondered whether AMSH can interact simultaneously with STAM and mVps24."
16431367
reach
"Hence, AMSH can simultaneously interact with both mVps24 and STAM, providing a direct connection between Hrs-STAM and ESCRTIII complexes."
16431367
Hsa-miR-218-2-3p affects STAMBP
2 |
Hsa-miR-218-2-3p decreases the amount of STAMBP. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-101-3p affects STAMBP
2 |
Hsa-miR-101-3p decreases the amount of STAMBP. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Complex affects STAMBP
| 2
Complex binds STAMBP. 2 / 2
| 2
reach
"The mammalian Hrs and STAM complex, equivalent to the Vps27 and Hse1 complex in budding yeast, binds two deubiquitinating enzymes, the JAMM and MPN+ family member AMSH (associated molecule with the SH3 domain of STAM) and the ubiquitin specific protease family member UBPY (ubiquitin isopeptidase Y)."
17660439
reach
"Recent studies showed that AMSH binds to the ESCRT and III complex in a STAM independent manner, in support of the suggestion that AMSH might be a counterpart of Doa4p."
17660439
VTI1B affects STAMBP
2 |
STAMBP binds VTI1B. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
VPS4A affects CHMP3
| 2
STAMBP binds CHMP3 and VPS4A. 2 / 2
| 2
sparser
"The MIM 1 sequence motif responsible for VPS4 interaction [ xref ] overlaps with the CHMP3-AMSH binding site and superpositioning of the VPS4A-CHMP1B and VPS4B-CHMP2A structures with AMSH-CHMP3 demonstrates the overlap of the binding motifs, which prohibits simultaneous binding of AMSH and VPS4 to CHMP3."
21827950
sparser
"Furthermore the AMSH binding site overlaps with the VPS4 site on CHMP3 ( xref ) [ xref , xref ], consistent with the finding that AMSH CHMP3 and VPS4 binding are exclusive (data not shown)."
21827950
UbV SP.3 affects STAMBP
| 2
UbV SP.3 inhibits STAMBP. 2 / 2
| 2
reach
"Full-length STAMBP activated with STAM1 was inhibited by both UbV SP.1 and UbV SP.3 , and the activity was reduced to 7% and 13%, respectively."
| DOI
reach
"Both UbV SP.1 and UbV SP.3 potently inhibited the isopeptidase activity of STAMBP JAMM (Fig. 5B ) and full-length STAMBP (Fig. 5C ) towards the cleavage of K63-linked poly-Ub chains."
| DOI
UbV SP.1 affects STAMBP
| 2
UbV SP.1 inhibits STAMBP.
| 1
UbV SP.1 inhibits STAMBP. 1 / 1
| 1
reach
"Full-length STAMBP activated with STAM1 was inhibited by both UbV SP.1 and UbV SP.3 , and the activity was reduced to 7% and 13%, respectively."
| DOI
UbV SP.1 activates STAMBP.
| 1
UbV SP.1 activates STAMBP. 1 / 1
| 1
reach
"In addition, we observed inhibition of STAM1-activated full-length STAMBP by both UbV SP.1 and UbV SP.3 in this chain cleavage assay (Fig. S2C) ."
| DOI
USP9X affects STAMBP
| 2
STAMBP binds USP9X. 2 / 2
| 2
reach
"In addition to USP9X, two other DUBs, USP8 and AMSH, bind and deubiquitinate the ESCRT-0 complex to sustain the sorting function of endosomes [15]."
37036745
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
UACA affects STAMBP
1 1 |
STAMBP binds UACA. 2 / 2
1 1 |
biogrid
No evidence text available
16730941
hprd
No evidence text available
16730941
Tobacco Smoke Pollution increases the amount of STAMBP. 2 / 2
2 |
ctd
No evidence text available
33660061
ctd
No evidence text available
28065790
TRH affects STAMBP
| 2
TRH activates STAMBP. 2 / 2
| 2
reach
"However, the present study indicates that SRIF does not modulate TRH induced aMSH release by frog neurointermediate lobes."
6140203
reach
"For doses ranging from 10 -9 to 10-6M, VIP did not significantly alter a-MSH secretion whereas TRH induced a marked increase in (x-MSH release with half-maximum stimulation (EDSO) at 1.2 x 10-8M Table[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
6140203
TNF affects STAMBP
| 2
TNF increases the amount of STAMBP. 2 / 2
| 2
reach
"We also found that the release of VEGFA, GDNF, CDCP1, OPG, uPA, AXIN1, FGF-5, MMP-1, MMP-10, PD-L1, HGF, Flt3L, 4E-BP1, DNER, CD40, CASP-8, ADA, TNFRSF9, NT-3, TWEAK and STAMBP were enhanced by the combination of TNF-α 50 ng/ml and TMAO compared to TNF-α 50 ng/ml alone (Fig. 6)."
38643262
reach
"We found that TNF-α alone, but not TMAO, significantly increased the release of VEGFA, GDNF, CDCP1, OPG, AXIN1, FGF-5, HGF, 4E-BP1, CD40, CASP-8, TNFRSF9, NT-3, STAMBP compared to unstimulated cells (Fig. 6)."
38643262
STAMBP affects p8
| 2
P8 binds STAMBP. 2 / 2
| 2
sparser
"On the contrary, the mutation of K 238 by T 238 (AMSH-P8) has a drastic negative effect on the binding affinity of AMSH (see Table 1 )."
27725184
sparser
"It is also noticeable from our ensemble of titration experiments that the directions of the shifts on UIM-SH3 are similar to that of the complete set of peptides from AMSH-P1 to AMSH-P8."
27725184
STAMBP affects p4
| 2
P4 binds STAMBP. 2 / 2
| 2
sparser
"In the light of these observations, it is likely that the P 239 residue of AMSH-P3 would be oriented in a direction close to the residues Trp246 and Glu224 of SH3, while 230 PP 231 of AMSH-P4 would po[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"To gain insight into the orientation of AMSH with respect to SH3, we used different AMSH peptide sequence containing either the P 239 (AMSH-P3) or the 230 PP 231 (AMSH-P4) motif."
27725184
STAMBP affects mVps24
| 2
STAMBP binds mVps24. 2 / 2
| 2
reach
"We wondered whether AMSH can interact simultaneously with STAM and mVps24."
16431367
reach
"Hence, AMSH can simultaneously interact with both mVps24 and STAM, providing a direct connection between Hrs-STAM and ESCRTIII complexes."
16431367
STAMBP affects endocytosis
| 2
STAMBP inhibits endocytosis.
| 1
STAMBP inhibits endocytosis. 1 / 1
| 1
reach
"AMSH (associated molecule with the SH3 domain of STAM; a JAMM DUB) and USP8/UBPY (ubiquitin-specific protease 8/ubiquitin-specific protease Y) negatively regulate endocytosis by cleaving K63 chains from internalized receptors [53, 54]."
32709994
STAMBP activates endocytosis.
| 1
STAMBP activates endocytosis. 1 / 1
| 1
reach
"AMSH mediates receptor endocytosis, which is accomplished through the recognition of specific ubiquitylation patterns, specifically multi-monoubiquitylation and Lys63-linked polyubiquitylation (Pan et al., 2022)."
39600336
STAMBP affects complex
| 2
Complex binds STAMBP. 2 / 2
| 2
reach
"The mammalian Hrs and STAM complex, equivalent to the Vps27 and Hse1 complex in budding yeast, binds two deubiquitinating enzymes, the JAMM and MPN+ family member AMSH (associated molecule with the SH3 domain of STAM) and the ubiquitin specific protease family member UBPY (ubiquitin isopeptidase Y)."
17660439
reach
"Recent studies showed that AMSH binds to the ESCRT and III complex in a STAM independent manner, in support of the suggestion that AMSH might be a counterpart of Doa4p."
17660439
STAMBP affects cell motility
| 2
STAMBP activates cell motility. 2 / 2
| 2
eidos
"STAMBP knockdown inhibits cell motility and invasion by attenuating MAPK signaling We used 2 siRNA fragments to reduce STAMBP expression in H1299 and A549 cells and then examined the ability of the cells to proliferate , migrate and invade ."
34102455
eidos
"Knockdown of STAMBP inhibits cell motility and invasion by attenuating MAPK signaling ."
34102455
STAMBP affects cell growth
| 2
STAMBP activates cell growth. 2 / 2
| 2
reach
"In mouse melanoma cells, aMSH may stimulate or inhibit cell growth, depending on tyrosinase activity and pigmentation of cells [23, 241."
2461309
reach
"Taken together, these findings demonstrated that RAI14 was critical for the STAMBP-mediated cell growth of TNBC cells."
36434041
STAMBP affects autophagy
| 2
STAMBP activates autophagy. 2 / 2
| 2
reach
"STAMBP may promote the stabilization of Unc-51-like autophagy-activating kinase 1 (ULK1) by removing its K48-linked ubiquitin chains, thereby participating in the regulation of autophagic flux ."
36434041
reach
"While the deubiquitinating enzyme USP20 and STAMBP/AMSH promote autophagy initiation by stabilizing ULK1 [21, 46], USP24 was found to negatively regulate autophagy and the stability of ULK1 [47]."
37607937
STAMBP inhibits apoptotic process.
| 1
STAMBP inhibits apoptotic process. 1 / 1
| 1
reach
"Given that previous studies in a mouse model showed that loss of STAMBP causes apoptosis in neuronal cells, we also stained for the apoptosis marker cleaved caspase 3 (CC3) (Figure 4E, fourth row)."
36033615
STAMBP activates apoptotic process.
| 1
Modified STAMBP activates apoptotic process. 1 / 1
| 1
reach
"Ectopic expression of AMSH prolongs BMP induced Smad1 phosphorylation, and potentiates BMP induced activation of transcriptional reporter activity, growth arrest and apoptosis."
11483516
STAMBP affects VTI1B
2 |
STAMBP binds VTI1B. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBP affects VAMP8
1 | 1
STAMBP deubiquitinates VAMP8.
| 1
STAMBP deubiquitinates VAMP8. 1 / 1
| 1
reach
"XREF_BIBR; XREF_BIBR; XREF_BIBR; XREF_BIBR During mitosis, AMSH deubiquitinates v-SNARE and VAMP8 in an ESCRT dependent manner, while also being present in the early phases of cytokinesis, both implicating a potential role of AMSH as a regulator of proliferation and survival."
21888914
STAMBP binds VAMP8.
1 |
VAMP8 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
18388320
STAMBP affects USP9X
| 2
STAMBP binds USP9X. 2 / 2
| 2
reach
"In addition to USP9X, two other DUBs, USP8 and AMSH, bind and deubiquitinate the ESCRT-0 complex to sustain the sorting function of endosomes [15]."
37036745
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
STAMBP affects UACA
1 1 |
STAMBP binds UACA. 2 / 2
1 1 |
biogrid
No evidence text available
16730941
hprd
No evidence text available
16730941
STAMBP affects TNBC
| 2
STAMBP activates TNBC. 2 / 2
| 2
reach
"We next asked whether RAI14 plays a key role in STAMBP-mediated TNBC progression."
36434041
reach
"RAI14 is required for STAMBP-mediated TNBC growth."
36434041
STAMBP affects TGFB
| 2
STAMBP inhibits TGFB.
| 1
STAMBP inhibits TGFB. 1 / 1
| 1
reach
"RNF11 may mediate AMSH ubiquitination through the formation of the Smurf2/RNF11 complex, leading to its degradation by the 26S proteasome, negatively regulating TGF-β signaling (199)."
39185411
STAMBP binds TGFB.
| 1
TGFB binds STAMBP. 1 / 1
| 1
reach
"This destabilizing effect of RNF11 appears to be effective in the transforming growth factor TGFβ and BMP signaling pathways, where RNF11 binds to the Smurf2 and AMSH proteins [14,15] ."
15707580
STAMBP affects Spondylolysis
| 2
STAMBP activates Spondylolysis. 2 / 2
| 2
reach
"56 On the other hand, we discovered that STAMBP could raise the risk of spondylolisthesis/spondylolysis."
38895179
reach
"STAM binding protein (STAMBP) and T-cell surface glycoprotein CD6 isoform (CD6 isoform) can increase the risk of spondylolisthesis/spondylolysis, whereas monocyte chemoattractant protein 2 (MCP2) and latency-associated peptide transforming growth factor beta 1 (LAP-TGF-beta1) can decrease spondylolisthesis/spondylolysis risk."
38895179
reach
"56 On the other hand, we discovered that STAMBP could raise the risk of spondylolisthesis/spondylolysis."
38895179
reach
"STAM binding protein (STAMBP) and T-cell surface glycoprotein CD6 isoform (CD6 isoform) can increase the risk of spondylolisthesis/spondylolysis, whereas monocyte chemoattractant protein 2 (MCP2) and latency-associated peptide transforming growth factor beta 1 (LAP-TGF-beta1) can decrease spondylolisthesis/spondylolysis risk."
38895179
STAMBP affects SMURF2
2 |
SMURF2 binds STAMBP. 2 / 2
2 |
biogrid
No evidence text available
14755250
biogrid
No evidence text available
14755250
STAMBP affects SMO
| 2
STAMBP binds SMO. 2 / 2
| 2
sparser
"Congruently, stably expressed AMSH fused to the ciliary signaling receptor Smoothened (SMO-AMSH) accumulated to high levels in cilia."
40766594
sparser
"However, syntaxin-3 did not accumulate in cilia of SMO-AMSH cells compared to cells expressing a catalytically dead variant (SMO-AMSH † ) ( xref – xref )."
40766594
STAMBP affects SMAD
| 2
STAMBP binds AMSH2 and SMAD. 1 / 1
| 1
sparser
"For example, TIEG and Foxp3 enhance TGF-β signaling through the repression of Smad7 gene expression ( xref , xref ), AMSH and AMSH2 interact with inhibitory Smads and suppress their effects ( xref , xref ), and Jab1/CSN5 induce Smad7 degradation ( xref )."
21795712
SMAD binds STAMBP. 1 / 1
| 1
sparser
"Inhibitory Smads, which act as negative regulators of signalling by competing with R-Smads, associate with AMSH."
16996268
STAMBP affects SLC25A41
2 |
SLC25A41 binds STAMBP. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBP affects SIRT2
| 1 1
STAMBP binds SIRT2. 2 / 2
| 1 1
sparser
"The interaction between STAMBP and SIRT2 ( R  = 0.97, p  = 8.52 × 10 -39 ) was found to be the most significant."
37293545
reach
"The interaction between STAMBP and SIRT2 (R = 0.97, p = 8.52 x 10 -39 ) was found to be the most significant."
37293545
STAMBP affects RDH12
2 |
RDH12 binds STAMBP. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBP affects RALBP1
2 |
STAMBP binds RALBP1. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBP affects PDIA6
| 2
PDIA6 binds STAMBP. 2 / 2
| 2
sparser
"Additionally, the peptides containing half of the AMSH-P2 sequence (AMSH-P5 and P6) did not exhibit any significant CSPs and hence no significant binding with SH3 (see Fig. S12A and B)."
27725184
sparser
"We determined a dissociation constant of 5.0 ± 1.5 mM for both AMSH-P5 and P6 that indicates a sizeable (if not abolished) reduction of the binding capability of AMSH."
27725184
reach
"The DUB signal transducing adaptor molecule-binding protein (STAMBP), an endosome-resident DUB, negatively regulates NLRP3 inflammasome activation."
36551253
reach
"A recent study found that STAMBP negatively regulates NLRP3 inflammasome activation [109]."
| PMC
STAMBP affects Mp10
| 2
STAMBP binds Mp10. 2 / 2
| 2
sparser
"Similarly, Mp10 destabilises immune‐related RKs, including FLS2 and FER, in a process that involves interaction of Mp10 with AMSH proteins – key deubiquitinating enzymes essential for protein trafficking – thereby rendering plants insensitive to PAMPs (Gravino et al .,  xref )."
40739716
sparser
"This is consistent with our recent findings that Mp10 associates with AMSH proteins, which function in the endosomal protein degradation pathway (Gravino et al .,  xref )."
40739716
STAMBP affects Melanoma
| 2
STAMBP activates Melanoma. 2 / 2
| 2
reach
"Previous studies have shown that STAMBP promotes the migration and invasion of lung cancer and melanoma cells ."
36434041
reach
"STAMBP suppression strongly inhibits melanoma metastasis in vivo ."
30454887
STAMBP affects MIT domain
| 2
STAMBP binds CHMP1A and MIT domain. 1 / 1
| 1
reach
"The AMSH MIT domain binds to CHMP1A, 1B, and 3 by multiple reports."
21332354
STAMBP binds CHMP3 and MIT domain. 1 / 1
| 1
reach
"This suggests that the AMSH MIT domain interaction with CHMP3 differs substantially from the low-affinity Vps4 MIT domain interaction."
18395747
STAMBP affects MIC-CAP
| 2
Mutated STAMBP activates MIC-CAP. 2 / 2
| 2
reach
"Elevated ubiquitin-conjugated protein aggregation and apoptosis activation has previously been identified in lymphoblastoid cell lines from patients with MIC-CAP caused by STAMBP mutations."
31638258
reach
"To the best of our knowledge, the present study reported the case of the first Chinese patient with MIC-CAP syndrome caused by a novel compound heterozygous STAMBP mutation."
31638258
STAMBP affects MC5R
| 2
STAMBP activates MC5R. 2 / 2
| 2
sparser
"ACTH (1–39) or α-MSH can activate MC1R, MC3R, MC4R, and MC5R ( xref ), but MC2R can only be activated by ACTH and not by α-MSH or other analogs ( xref )."
28228747
sparser
"ACTH can activate all five receptor subtypes; of the melanocortins, only ACTH activates MC2R; ACTH as well as α-MSH, β-MSH and γ-MSH activate MC1R, MC3R, MC4R and MC5R, although with varying affinities."
28805746
STAMBP affects MAP2K5
1 1 |
STAMBP binds MAP2K5. 2 / 2
1 1 |
biogrid
No evidence text available
16730941
hprd
No evidence text available
16730941
STAMBP affects JAMM-family deubiquitinating enzyme
| 2
STAMBP deubiquitinates JAMM-family deubiquitinating enzyme. 2 / 2
| 2
reach
"STAM binding protein, or STAMBP, is a JAMM-family deubiquitinating enzyme with microtubule-interacting/transport and STAM-binding domains."
38742115
reach
"STAM-binding protein, STAMBP, is a JAMM-family deubiquitinating enzyme containing the microtubule-interacting/transport domain and STAM-binding domain, which mainly deubiquitinates K63-linked ubiquiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30454887
STAMBP affects JAB
| 2
STAMBP binds JAB. 2 / 2
| 2
sparser
"Dysregulated STAMBP expression induces oncogenic features through altered ubiquitin signaling of substrate proteins by directly binding with the C-terminal JAMM domain of STAMBP, which could facilitate cellular transformation and tumor development."
41301420
sparser
"The AMSH-family JAMM domains bind two zinc ions, one a structural zinc ion bound to the conserved JAMM core, and the second a catalytic zinc ion bound by residues of Ins-2."
21332354
STAMBP affects IFITM3
1 1 |
IFITM3 binds STAMBP. 2 / 2
1 1 |
biogrid
No evidence text available
34709727
virhostnet
No evidence text available
34709727
STAMBP affects IFITM1
1 1 |
IFITM1 binds STAMBP. 2 / 2
1 1 |
biogrid
No evidence text available
34709727
virhostnet
No evidence text available
34709727
STAMBP affects Hrs
| 2
STAMBP phosphorylates Hrs on tyrosine. 2 / 2
| 2
rlimsp
"In contrast, EGF activation of EGFR-ErbB2 showed significantly decreased Hrs tyrosine phosphorylation and deubiquitination by AMSH."
22800866
rlimsp
"EGF stimulation of the EGFR resulted in efficient Hrs tyrosine phosphorylation and deubiquitination by the K63-polyubiquitin chain-specific deubiquitinating enzyme AMSH."
22800866
STAMBP affects EV-Cx43
| 2
STAMBP activates EV-Cx43. 2 / 2
| 2
eidos
"Here , depletion of AMSH decreased EV-Cx43 levels , suggesting that lysosomal degradation of Cx43 was promoted , whereas knockdown of USP8 up-regulated the release of ubiquitinated Cx43 in EVs ."
33097557
eidos
"Our results show that siRNA-mediated knockdown of USP8 increased EV-Cx43 release , as well as the total number of vesicles , whereas depletion of AMSH decreased EV-Cx43 levels ( Figs 4C and S5I ) ."
33097557
STAMBP affects EPS15
1 | 1
RNF11 binds EPS15 and STAMBP. 1 / 1
| 1
sparser
"We found that RNF11 associates with EPS-15 and AMSH, which is the molecule associated with the SH3 domain of STAM (AMSH)."
16925951
EPS15 binds STAMBP. 1 / 1
1 |
hprd
No evidence text available
14755250
STAMBP affects Dnmt1
| 1 1
Dnmt1 binds STAMBP. 2 / 2
| 1 1
reach
"For the current complex and from the UIM-SH3 side, the dissociation rate constant and the dissociation constant are 117 ± 43 s − 1 and 2.0 ± 0.7 μM at 288 K, respectively (see Fig. S7 and Table 1 ), i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"Furthermore, we wanted to understand this activation phenomenon in more detail, in terms ofk cat and K M . To this end, we carried out another kinetic assay in which the catalytic domain of AMSH was pre-incubated in the presence of 20-fold excess UIM-SH3 to ensure that equilibrium favors the formation of the AMSH-UIM-SH3 complex."
24151880
STAMBP affects Death
| 2
STAMBP bound to GRB2 activates Death. 1 / 1
| 1
reach
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12-14], we speculate that the neuronal cell death in the AMSH deficient brain might be caused by the lack of interaction [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
STAMBP bound to STAM activates Death. 1 / 1
| 1
reach
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12-14], we speculate that the neuronal cell death in the AMSH deficient brain might be caused by the lack of interaction [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
STAMBP affects CTNNBL1
1 1 |
STAMBP binds CTNNBL1. 2 / 2
1 1 |
biogrid
No evidence text available
16730941
hprd
No evidence text available
16730941
STAMBP affects CHMP4A
2 |
STAMBP binds CHMP4A. 2 / 2
2 |
biogrid
No evidence text available
17711858
biogrid
No evidence text available
16730941
STAMBP affects CHMP proteins
| 2
STAMBP binds CHMP proteins. 2 / 2
| 2
reach
"AMSH and USP8 can also interact with CHMP proteins that are components of the late ESCRT-III machinery XREF_BIBR, XREF_BIBR."
26918171
reach
"Of particular interest was the formation of a network connecting CHMP1A, CHMP4B, and CHMP5 with UBE2I, SUMO1, PIAS2, and HIPK2, all of which are known to be involved in nuclear sumolation processes.In[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
STAMBP affects BMP2K
2 |
STAMBP binds BMP2K. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBP affects BMP
| 2
Modified STAMBP activates BMP. 2 / 2
| 2
reach
"Ectopic expression of AMSH prolongs BMP induced Smad1 phosphorylation, and potentiates BMP induced activation of transcriptional reporter activity, growth arrest and apoptosis."
11483516
reach
"Ectopic expression of AMSH enhanced BMP mediated Smad1 phosphorylation, and increased BMP induced reporter activity, growth arrest and apoptosis (Itoh et al., 2001)."
27155333
STAMBP affects AXIN1
| 2
STAMBP binds AXIN1. 2 / 2
| 2
sparser
"Network fragmentation becomes even more pronounced in xref : the AXIN1–STAMBP positive link is intensified (R² = 0.9640, P < 0.0001; xref ), while strong negative correlations simultaneously appear for FGF-19–TNFSF14 (R² = 0.6311, P = 0.0105; xref ) and CXCL9–TWEAK, generating a conspicuous pro- versus anti-inflammatory opposition."
41624893
sparser
"Linear modelling further identifies a strong positive AXIN1–STAMBP relationship (R² = 0.7922, P < 0.0001; xref ), indicating that homeostasis is maintained by multiple co-equal covariance axes."
41624893
STAMBP affects AVP
| 2
USP8 binds STAMBP and AVP. 1 / 1
| 1
sparser
"Like Doa4 in yeast, mammalian Usp8 and AMSH associate with class E Vps proteins on endosomes."
19489724
STAMBP binds AVP. 1 / 1
| 1
sparser
"Similarly, the mammalian deubiquitinating enzyme AMSH binds directly to the ESCRT-III subunit Vps24, although it is not known if Vps24 mediates endosomal recruitment of this enzyme [30–34] ."
16716591
STAMBP affects AP2A1
2 |
STAMBP binds AP2A1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBP affects AMN
1 1 |
STAMBP binds AMN. 2 / 2
1 1 |
hprd
No evidence text available
16730941
biogrid
No evidence text available
16730941
STAMBP affects ALAS1
1 1 |
STAMBP binds ALAS1. 2 / 2
1 1 |
hprd
No evidence text available
16730941
biogrid
No evidence text available
16730941
STAM affects HGS
| 1 1
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
STAM binds HGS and STAMBP. 1 / 1
| 1
reach
"Thus, the STAM, Hrs, and AMSH complex may engage in a tripartite interaction with clathrin, embedding it within the endosomal coat structure.Hrs serves to recruit downstream components of the MVB sort[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
SP affects STAMBP
| 2
SP inhibits STAMBP. 2 / 2
| 2
sparser
"Full-length STAMBP activated with STAM1 was inhibited by both UbV SP."
34425109
sparser
"In addition, we observed inhibition of STAM1-activated full-length STAMBP by both UbV SP."
34425109
SMO affects STAMBP
| 2
STAMBP binds SMO. 2 / 2
| 2
sparser
"Congruently, stably expressed AMSH fused to the ciliary signaling receptor Smoothened (SMO-AMSH) accumulated to high levels in cilia."
40766594
sparser
"However, syntaxin-3 did not accumulate in cilia of SMO-AMSH cells compared to cells expressing a catalytically dead variant (SMO-AMSH † ) ( xref – xref )."
40766594
SMAD affects STAMBP
| 2
STAMBP binds AMSH2 and SMAD. 1 / 1
| 1
sparser
"For example, TIEG and Foxp3 enhance TGF-β signaling through the repression of Smad7 gene expression ( xref , xref ), AMSH and AMSH2 interact with inhibitory Smads and suppress their effects ( xref , xref ), and Jab1/CSN5 induce Smad7 degradation ( xref )."
21795712
SMAD binds STAMBP. 1 / 1
| 1
sparser
"Inhibitory Smads, which act as negative regulators of signalling by competing with R-Smads, associate with AMSH."
16996268
SLC25A41 affects STAMBP
2 |
SLC25A41 binds STAMBP. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
SIRT2 affects STAMBP
| 1 1
STAMBP binds SIRT2. 2 / 2
| 1 1
sparser
"The interaction between STAMBP and SIRT2 ( R  = 0.97, p  = 8.52 × 10 -39 ) was found to be the most significant."
37293545
reach
"The interaction between STAMBP and SIRT2 (R = 0.97, p = 8.52 x 10 -39 ) was found to be the most significant."
37293545
RDH12 affects STAMBP
2 |
RDH12 binds STAMBP. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RALBP1 affects STAMBP
2 |
STAMBP binds RALBP1. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
PDPK1 affects STAMBP
| 2
STAMBP binds PDPK1. 2 / 2
| 2
sparser
"However, co-immunoprecipitation (Co-IP) revealed no direct interaction between STAMBP and PDK1 (Fig. xref and Supplementary Fig. xref )."
39242557
sparser
"To further elucidate the mechanism by which STAMBP modulates STAMBP expression in PC cells, we investigated whether there are direct interactions between STAMBP and PDK1."
39242557
PDIA6 affects STAMBP
| 2
PDIA6 binds STAMBP. 2 / 2
| 2
sparser
"Additionally, the peptides containing half of the AMSH-P2 sequence (AMSH-P5 and P6) did not exhibit any significant CSPs and hence no significant binding with SH3 (see Fig. S12A and B)."
27725184
sparser
"We determined a dissociation constant of 5.0 ± 1.5 mM for both AMSH-P5 and P6 that indicates a sizeable (if not abolished) reduction of the binding capability of AMSH."
27725184
NLRP7 affects STAMBP
1 | 1
NLRP7 binds Ubiquitin and STAMBP. 1 / 1
| 1
sparser
"Further, we introduce the small molecule BC-1471, which interrupts STAMBP-Ub-NALP7 interaction and suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, peripheral blood mononuclear cells and lung organ culture."
28492230
STAMBP binds NLRP7. 1 / 1
1 |
biogrid
No evidence text available
28492230
N-ethylmaleimide affects STAMBP
| 2
reach
"Previous studies have shown that N-ethylmaleimide (NEM) inhibits AMSH activity (IC 50 of 16.2 +/- 3.2 microM), presumably by modifying one of these two cysteines, perhaps Cys282 because it is proximal to the active-site cleft."
24151880
reach
"We found AMSH activity was inhibited by N-ethylmaleimide (NEM) treatment, and also inhibited by zinc chelating agents (XREF_FIG b), as expected for a metalloprotease."
15314065
Mp10 affects STAMBP
| 2
STAMBP binds Mp10. 2 / 2
| 2
sparser
"Similarly, Mp10 destabilises immune‐related RKs, including FLS2 and FER, in a process that involves interaction of Mp10 with AMSH proteins – key deubiquitinating enzymes essential for protein trafficking – thereby rendering plants insensitive to PAMPs (Gravino et al .,  xref )."
40739716
sparser
"This is consistent with our recent findings that Mp10 associates with AMSH proteins, which function in the endosomal protein degradation pathway (Gravino et al .,  xref )."
40739716
MIT domain affects STAMBP
| 2
STAMBP binds CHMP1A and MIT domain. 1 / 1
| 1
reach
"The AMSH MIT domain binds to CHMP1A, 1B, and 3 by multiple reports."
21332354
STAMBP binds CHMP3 and MIT domain. 1 / 1
| 1
reach
"This suggests that the AMSH MIT domain interaction with CHMP3 differs substantially from the low-affinity Vps4 MIT domain interaction."
18395747
MC4R affects STAMBP
| 2
STAMBP binds MC4R. 2 / 2
| 2
sparser
"By comparison, α–MSH bound to MC4R with a 4.5-fold higher affinity (K d = 11.93 ± 1.23 nM) than LCN2 and competed for binding with LCN2 with aK i of 12.63 ± 1.10 nM ( xref and xref )."
28273060
sparser
"Together with inhibiting the activity of the POMC/CART neurons through a GABAergic effect (Pu et al., xref ), they release AgRP, a characterized anabolic peptide able to competitively inhibit α–MSH binding to the MC4R (Ollmann et al., xref )."
28690493
MC1R affects STAMBP
| 2
STAMBP binds MC1R. 2 / 2
| 2
reach
"[5] a-Melanocyte stimulating hormone (a-MSH), which binds to MSH-R, a G protein coupled receptor also known as the melanocortin-1 receptor (MC1-R) [6] activates AC, thereby increasing the amount of cAMP in the cell."
12503631
reach
"Binding of aMSH to MC1R may be functionally protective against UV-induced DNA damage as aMSH pretreatment of melanocytes can reduce generation of UV-induced oxidative byproducts, an effect that was absent in melanocytes expressing loss-of-function MC1R, suggesting the mechanism mediating this susceptibility may be independent of pigmentation."
37790306
MAP2K5 affects STAMBP
1 1 |
STAMBP binds MAP2K5. 2 / 2
1 1 |
biogrid
No evidence text available
16730941
hprd
No evidence text available
16730941
JAB affects STAMBP
| 2
STAMBP binds JAB. 2 / 2
| 2
sparser
"Dysregulated STAMBP expression induces oncogenic features through altered ubiquitin signaling of substrate proteins by directly binding with the C-terminal JAMM domain of STAMBP, which could facilitate cellular transformation and tumor development."
41301420
sparser
"The AMSH-family JAMM domains bind two zinc ions, one a structural zinc ion bound to the conserved JAMM core, and the second a catalytic zinc ion bound by residues of Ins-2."
21332354
IL1B affects STAMBP
| 2
IL1B inhibits STAMBP.
| 1
IL1B inhibits STAMBP. 1 / 1
| 1
reach
"Blocking the function of STAM-binding Protein (STAMBP) decreases the level of IL-1β, one of the most important inflammation cytokines."
32722615
IL1B activates STAMBP.
| 1
IL1B activates STAMBP. 1 / 1
| 1
reach
"Blocking the function of STAM-binding Protein (STAMBP) decreases the level of IL-1β, one of the most important inflammation cytokines."
32722615
IFITM3 affects STAMBP
1 1 |
IFITM3 binds STAMBP. 2 / 2
1 1 |
biogrid
No evidence text available
34709727
virhostnet
No evidence text available
34709727
IFITM1 affects STAMBP
1 1 |
IFITM1 binds STAMBP. 2 / 2
1 1 |
biogrid
No evidence text available
34709727
virhostnet
No evidence text available
34709727
HGS affects STAM
| 1 1
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
STAM binds HGS and STAMBP. 1 / 1
| 1
reach
"Thus, the STAM, Hrs, and AMSH complex may engage in a tripartite interaction with clathrin, embedding it within the endosomal coat structure.Hrs serves to recruit downstream components of the MVB sort[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
EPS15 affects STAMBP
1 | 1
RNF11 binds EPS15 and STAMBP. 1 / 1
| 1
sparser
"We found that RNF11 associates with EPS-15 and AMSH, which is the molecule associated with the SH3 domain of STAM (AMSH)."
16925951
EPS15 binds STAMBP. 1 / 1
1 |
hprd
No evidence text available
14755250
Dnmt1 affects STAMBP
| 1 1
Dnmt1 binds STAMBP. 2 / 2
| 1 1
reach
"For the current complex and from the UIM-SH3 side, the dissociation rate constant and the dissociation constant are 117 ± 43 s − 1 and 2.0 ± 0.7 μM at 288 K, respectively (see Fig. S7 and Table 1 ), i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"Furthermore, we wanted to understand this activation phenomenon in more detail, in terms ofk cat and K M . To this end, we carried out another kinetic assay in which the catalytic domain of AMSH was pre-incubated in the presence of 20-fold excess UIM-SH3 to ensure that equilibrium favors the formation of the AMSH-UIM-SH3 complex."
24151880
CUL3 affects STAMBP
| 1 1
CUL3 ubiquitinates STAMBP. 2 / 2
| 1 1
reach
"However, the protein levels of USP8 and AMSH seem unchanged upon Cul3-depletion, implying that Cul3 ubiquitination of USP8 and AMSH does not trigger their degradation."
23739092
sparser
"However, the protein levels of USP8 and AMSH seem unchanged upon Cul3-depletion, implying that Cul3 ubiquitination of USP8 and AMSH does not trigger their degradation."
23739092
CTNNBL1 affects STAMBP
1 1 |
STAMBP binds CTNNBL1. 2 / 2
1 1 |
biogrid
No evidence text available
16730941
hprd
No evidence text available
16730941
CHUK affects STAMBP
| 2
CHUK phosphorylates STAMBP on S2. 2 / 2
| 2
sparser
"Overall, IKKα phosphorylates STAMBP at Ser 2, which activates STAMBP to deubiquitinase BAG3, thus resulting in an IKKα/STAMBP/BAG3 signaling axis that promotes PDAC progression."
41611844
sparser
"Moreover, a phosphorylation-dependent mechanism of STAMBP was identified as follows: STAMBP is phosphorylated by IKKα at Ser2 without affecting STAMBP protein abundance, and this phosphorylation enables it to deubiquitinate BAG3."
41611844
CHMP4A affects STAMBP
2 |
STAMBP binds CHMP4A. 2 / 2
2 |
biogrid
No evidence text available
17711858
biogrid
No evidence text available
16730941
CHMP3 affects VPS4A
| 2
STAMBP binds CHMP3 and VPS4A. 2 / 2
| 2
sparser
"The MIM 1 sequence motif responsible for VPS4 interaction [ xref ] overlaps with the CHMP3-AMSH binding site and superpositioning of the VPS4A-CHMP1B and VPS4B-CHMP2A structures with AMSH-CHMP3 demonstrates the overlap of the binding motifs, which prohibits simultaneous binding of AMSH and VPS4 to CHMP3."
21827950
sparser
"Furthermore the AMSH binding site overlaps with the VPS4 site on CHMP3 ( xref ) [ xref , xref ], consistent with the finding that AMSH CHMP3 and VPS4 binding are exclusive (data not shown)."
21827950
CHMP proteins affects STAMBP
| 2
STAMBP binds CHMP proteins. 2 / 2
| 2
reach
"AMSH and USP8 can also interact with CHMP proteins that are components of the late ESCRT-III machinery XREF_BIBR, XREF_BIBR."
26918171
reach
"Of particular interest was the formation of a network connecting CHMP1A, CHMP4B, and CHMP5 with UBE2I, SUMO1, PIAS2, and HIPK2, all of which are known to be involved in nuclear sumolation processes.In[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
BMP2K affects STAMBP
2 |
STAMBP binds BMP2K. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
BC-1471 affects STAMBP
| 2
BC-1471 inhibits STAMBP. 2 / 2
| 2
reach
"As STAMBP activity is specific for K63 linked ubiquitin XREF_BIBR, BC-1471 inhibition of STAMBP mediated cleavage of K63 linked di-Ub demonstrates physiologically relevant target validation for our compound."
28492230
reach
"BC-1471 inhibited the activity of STAMBP to cleave recombinant di-Ub in a concentration dependent manner with an half-maximal inhibitory concentration (IC 50) of 0.33 muM (0.09-1.21 muM; XREF_FIG)."
28492230
AXIN1 affects STAMBP
| 2
STAMBP binds AXIN1. 2 / 2
| 2
sparser
"Network fragmentation becomes even more pronounced in xref : the AXIN1–STAMBP positive link is intensified (R² = 0.9640, P < 0.0001; xref ), while strong negative correlations simultaneously appear for FGF-19–TNFSF14 (R² = 0.6311, P = 0.0105; xref ) and CXCL9–TWEAK, generating a conspicuous pro- versus anti-inflammatory opposition."
41624893
sparser
"Linear modelling further identifies a strong positive AXIN1–STAMBP relationship (R² = 0.7922, P < 0.0001; xref ), indicating that homeostasis is maintained by multiple co-equal covariance axes."
41624893
AVP affects STAMBP
| 2
USP8 binds STAMBP and AVP. 1 / 1
| 1
sparser
"Like Doa4 in yeast, mammalian Usp8 and AMSH associate with class E Vps proteins on endosomes."
19489724
STAMBP binds AVP. 1 / 1
| 1
sparser
"Similarly, the mammalian deubiquitinating enzyme AMSH binds directly to the ESCRT-III subunit Vps24, although it is not known if Vps24 mediates endosomal recruitment of this enzyme [30–34] ."
16716591
AP2A1 affects STAMBP
2 |
STAMBP binds AP2A1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
AMN affects STAMBP
1 1 |
STAMBP binds AMN. 2 / 2
1 1 |
hprd
No evidence text available
16730941
biogrid
No evidence text available
16730941
ALAS1 affects STAMBP
1 1 |
STAMBP binds ALAS1. 2 / 2
1 1 |
hprd
No evidence text available
16730941
biogrid
No evidence text available
16730941
AGRP affects STAMBP
| 2
AGRP binds STAMBP. 2 / 2
| 2
sparser
"The recruitment of β-arrestins and the consecutive internalization of the neural MCRS is observed following binding of either AgRP or α–MSH [ xref ]."
23680515
sparser
"When adherence to DASH and MDS was low, the obesity risk allele was associated with higher means of AgRP and α–MSH among women and men, respectively."
| PMC
17alpha-ethynylestradiol increases the amount of STAMBP. 2 / 2
2 |
ctd
No evidence text available
23129252
ctd
No evidence text available
17942748
Vinclozolin affects STAMBP
1 |
Vinclozolin decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
23034163
Valproic acid affects STAMBP
1 |
Valproic acid demethylates STAMBP. 1 / 1
1 |
ctd
No evidence text available
29154799
Snf7 affects STAM
| 1
STAMBP binds STAM and snf7. 1 / 1
| 1
sparser
"Recent studies showed that AMSH binds to the ESCRT-III complex in a STAM-independent manner ( xref ; xref ), in support of the suggestion that AMSH might be a counterpart of Doa4p ( xref )."
17660439
Silicon dioxide affects STAMBP
1 |
Silicon dioxide decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
19073995
Rosiglitazone affects STAMBP
1 |
Rosiglitazone decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
17639046
Phorbol 13-acetate 12-myristate decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
25613284
P802 affects STAMBP
| 1
P802 activates STAMBP. 1 / 1
| 1
eidos
"As predicted , osm-3 ( p802 ) promoted ectocytosis of GCY-22-GFP towards AMsh ( Figure 4G ) ."
34533135
Nitrofen affects STAMBP
1 |
Nitrofen decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
26720608
Monomethylarsonous acid decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
23487506
MiR-99a-3p affects STAMBP
| 1
MiR-99a-3p activates STAMBP. 1 / 1
| 1
reach
"Next, we performed dual-luciferase reporter assays to determine whether STAMBP was directly regulated by miR-99a-3p."
31795200
Methylmercury chloride decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
23103053
Methyl methanesulfonate increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
23649840
Methimazole affects STAMBP
1 |
Methimazole decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
30047161
Methidathion affects STAMBP
1 |
Methidathion decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
34813904
Leptin receptors affects STAMBP
| 1
Leptin receptors increases the amount of STAMBP. 1 / 1
| 1
reach
"Stimulation of leptin receptors in the ventromedial hypothalamus triggered the release of aMSH."
16102938
Kappa opioid receptors affects STAMBP
| 1
Kappa opioid receptors activates STAMBP. 1 / 1
| 1
reach
"The observation that blockade of kappa opioid receptors with NOR-BNI decreases the secretion of aMSH in both male and female rats suggests that endogenous kappa opioids tonically stimulate the secreti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8394964
Ivermectin affects STAMBP
1 |
Ivermectin decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
32959892
Isotretinoin affects STAMBP
1 |
Isotretinoin decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
20436886
Ionomycin affects STAMBP
1 |
Ionomycin decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
25613284
Hydrogen chloride activates STAMBP. 1 / 1
| 1
reach
"We published that the Cl - /HCO 3 - permeable channel CLH-1 mediates intracellular pH buffering of C. elegans Amphid sheath (AMsh) glia at baseline."
35047763
Hsa-mir-548v affects STAMBP
1 |
Hsa-mir-548v decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-mir-4489 affects STAMBP
1 |
Hsa-mir-4489 decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-mir-4273 affects STAMBP
1 |
Hsa-mir-4273 decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-758-5p affects STAMBP
1 |
Hsa-miR-758-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-7156-5p affects STAMBP
1 |
Hsa-miR-7156-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6813-5p affects STAMBP
1 |
Hsa-miR-6813-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6757-3p affects STAMBP
1 |
Hsa-miR-6757-3p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6739-3p affects STAMBP
1 |
Hsa-miR-6739-3p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6085 affects STAMBP
1 |
Hsa-miR-6085 decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-584-5p affects STAMBP
1 |
Hsa-miR-584-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-526b-5p affects STAMBP
1 |
Hsa-miR-526b-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-505-3p affects STAMBP
1 |
Hsa-miR-505-3p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-4677-5p affects STAMBP
1 |
Hsa-miR-4677-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-432-5p affects STAMBP
1 |
Hsa-miR-432-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-221-3p affects STAMBP
1 |
Hsa-miR-221-3p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-22-5p affects STAMBP
1 |
Hsa-miR-22-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-2116-5p affects STAMBP
1 |
Hsa-miR-2116-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-144-3p affects STAMBP
1 |
Hsa-miR-144-3p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-139-5p affects STAMBP
1 |
Hsa-miR-139-5p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1-3p affects STAMBP
1 |
Hsa-miR-1-3p decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Fenthion affects STAMBP
1 |
Fenthion decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
34813904
Eas-1 homolog affects STAMBP
| 1
Eas-1 homolog activates STAMBP. 1 / 1
| 1
reach
"As the expression of the human eas-1 homolog, GOLT1B, can rescue the enlarged AMsh phenotypes in eas-1 mutants, the findings we reported here are likely to be an evolutionarily conserved mechanism of glial size regulation."
33370778
Dorsomorphin affects STAMBP
1 |
Dorsomorphin decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
27188386
Dopamine- affects STAMBP
| 1
Dopamine- inhibits STAMBP. 1 / 1
| 1
reach
"Comparison of dopamine- and NPY induced inhibition of the aMSH secretion (A) and cAMP release (B) in neurointermediate lobes."
7479331
Diethylstilbestrol decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
36621641
Dibutyl phthalate decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
17361019
Cyclosporin A affects STAMBP
1 |
Cyclosporin A increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
25562108
Chlorpyrifos affects STAMBP
1 |
Chlorpyrifos increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
37019170
Cadmium dichloride decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
33453195
Bisphenol F affects STAMBP
1 |
Bisphenol F decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
36041667
Bis(2-ethylhexyl) phthalate increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
34319233
Amitrole affects STAMBP
1 |
Amitrole decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
30047161
Amantadine affects STAMBP
| 1
Amantadine inhibits STAMBP. 1 / 1
| 1
reach
"The A/MS-H 275Y virus was also inhibited by amantadine and rimantadine whereas the A/HK-H 275Y was resistant to the adamantanes."
22809862
Aflatoxin B1 affects STAMBP
1 |
Aflatoxin B1 increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
22100608
Abrine affects STAMBP
1 |
Abrine increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
31054353
Vehicle Emissions demethylates STAMBP. 1 / 1
1 |
ctd
No evidence text available
25560391
VHL affects STAMBP
1 |
VHL binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
35205757
VAMP8 affects STAMBP
1 |
VAMP8 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
18388320
Ubs affects STAMBP
| 1
STAMBP binds Ubs. 1 / 1
| 1
reach
"Maybe it has to be preceded to get more information about poly- and mono-ubiquitination on specific targets in protein degradation and sorting in order to know the criteria for distinguishing ubiqutin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17078930
Ubiquitin affects RIPK2
| 1
STAMBP binds RIPK2 and Ubiquitin. 1 / 1
| 1
sparser
"Next we purified ubiquitin conjugates from L18-MDP-stimulated Mysm1 − /− BMDMs by TUBE and incubated them with recombinant MYSM1 (Rec-MYSM1) and compared the ubiquitin restriction pattern of Ub-RIP2 with that of AMSH, UCHL3, OTULIN or a combination of these three DUBs (Fig.  xref )."
30405132
Ubiquitin affects NLRP7
| 1
NLRP7 binds Ubiquitin and STAMBP. 1 / 1
| 1
sparser
"Further, we introduce the small molecule BC-1471, which interrupts STAMBP-Ub-NALP7 interaction and suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, peripheral blood mononuclear cells and lung organ culture."
28492230
Ubiquitin affects K63
| 1
STAMBP binds K63 and Ubiquitin. 1 / 1
| 1
sparser
"This is best illustrated by the structure obtained for a catalytically inactive variant of AMSH bound to K63-linked Ub dimer ( xref )."
22196026
USP8 affects MITD1
| 1
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
USP8 affects HRS
| 1
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
USP8 affects HGS
| 1
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
USP8 affects CHMP4B
| 1
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
USP8 affects CHMP3
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
USP8 affects CHMP1B
1 |
USP8 binds STAMBP and CHMP1B. 1 / 1
1 |
hprd
No evidence text available
17711858
USP8 affects CHMP1A
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
USP8 affects AVP
| 1
USP8 binds STAMBP and AVP. 1 / 1
| 1
sparser
"Like Doa4 in yeast, mammalian Usp8 and AMSH associate with class E Vps proteins on endosomes."
19489724
USP7 affects STAMBP
| 1
STAMBP binds USP7. 1 / 1
| 1
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
USP49 affects STAMBP
| 1
USP49 binds STAMBP. 1 / 1
| 1
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
USP33 affects STAMBP
| 1
STAMBP binds USP33. 1 / 1
| 1
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
USP28 affects STAMBP
1 |
USP28 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP20 affects STAMBP
| 1
STAMBP binds USP20. 1 / 1
| 1
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
UIM affects STAMBP
| 1
UIM inhibits STAMBP. 1 / 1
| 1
reach
"Moreover, removal or mutations of either the STAM UIM or SH3 domain reduce the AMSH catalytic activity toward Lys63-Ub 2 chains [23–25] ."
27725184
UBE2S affects STAMBP
1 |
STAMBP binds UBE2S. 1 / 1
1 |
biogrid
No evidence text available
20622874
UBD affects I44
| 1
STAMBP binds UBD and I44. 1 / 1
| 1
reach
"Inspection of our structural model representing AMSH and diubiquitin complex reveals that the I44 patch of the distal ubiquitin is satisfied, with the Ile44 residue engaged in van der Waals interaction with Phe320; however, Ile44 of the proximal ubiquitin is unoccupied (XREF_SUPPLEMENTARY)."
24151880
TUBA1A affects STAMBP
| 1
COL4A1 binds MIR17HG, TUBA1A, SLC2A1, and STAMBP. 1 / 1
| 1
sparser
"Interestingly, we found several differentially expressed genes following infection with ZIKV Uganda, including COL4A1 , MIR17HG , TUBA1A , SLC2A1 and STAMBP , which are associated with microcephaly according to the comparative toxicogenomics database [ xref ]."
33121145
TRIP13 affects STAMBP
1 |
STAMBP binds TRIP13. 1 / 1
1 |
biogrid
No evidence text available
19060904
TP53 affects STAMBP
1 |
STAMBP binds TP53. 1 / 1
1 |
biogrid
No evidence text available
27561390
TOPBP1 affects STAMBP
1 |
TOPBP1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
41524403
TNFSF14 affects STAMBP
| 1
STAMBP binds TNFSF14. 1 / 1
| 1
sparser
"Significant results found only in the male stratum include negative associations of STAMBP and TNFSF14 with TCBV (β=−0.14,−0.14, see Figure  xref ), IL6 and 4E."
39282876
TNFRSF1A affects STAMBP
1 |
STAMBP binds TNFRSF1A. 1 / 1
1 |
biogrid
No evidence text available
24980434
TGFB affects STAMBP
| 1
TGFB binds STAMBP. 1 / 1
| 1
reach
"This destabilizing effect of RNF11 appears to be effective in the transforming growth factor TGFβ and BMP signaling pathways, where RNF11 binds to the Smurf2 and AMSH proteins [14,15] ."
15707580
STAMBPL1 affects Clathrin
| 1
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBP affects ‐1β
| 1
STAMBP increases the amount of ‐1β. 1 / 1
| 1
reach
"55 Studies showed that STAMBP can increase NACHT, LRR and PYD domains‐containing protein 7 (NALP7) inflammasome and IL‐1β levels to promote inflammation through deubiquitination."
38895179
STAMBP affects various membrane components including CXCR4 PAR2 Cx43
| 1
STAMBP inhibits various membrane components including CXCR4 PAR2 Cx43. 1 / 1
| 1
eidos
"Consistently , STAMBP contributes to the degradation of various membrane components , including CXCR4 , PAR2 and Cx43 , via its localization in the ESCRT complex and endosomes [ 16,27,29 ] ."
34102455
STAMBP affects subclone EL4-6.1
| 1
STAMBP inhibits subclone EL4-6.1. 1 / 1
| 1
reach
"In addition, Mugridge et al. (1 l) demonstrated that aMSH (11-13) potently and selectively reduced [" I]-IL-1 binding to the IL-1 type I (80 kDa) receptor binding, T-cell subclone EL4-6.1."
8387184
STAMBP affects recycling receptor
| 1
STAMBP activates recycling receptor. 1 / 1
| 1
eidos
"STAMBP has been shown to deubiquitinate EGFR and therefore promote the recycling of the receptor [ 8,10 ] ."
34102455
STAMBP affects processes
| 1
STAMBP activates processes. 1 / 1
| 1
eidos
"STAMBP overexpression promoted cell migration and invasion , whereas STAMBP knockdown attenuated these processes in LUAD cells after epidermal growth factor treatment ."
34102455
STAMBP affects polyubiquitination
| 1
STAMBP inhibits polyubiquitination. 1 / 1
| 1
eidos
"The results demonstrated that overexpression of FH-STAMBP decreased EGFR polyubiquitination ( Fig. 3B ) whereas STAMBP knockdown promoted EGFR polyubiquitination upon EGF treatment ( Fig. 3C ) ."
34102455
STAMBP affects polyubiquitin chains
| 1
STAMBP deubiquitinates polyubiquitin chains on E1. 1 / 1
| 1
reach
"Furthermore, these polyubiquitin chains could be deubiquitinated by AMSH (associated molecule with the SH3 domain of STAM), a K63-linkage-specific deubiquitinase ( Fig. 1 E)."
32139119
STAMBP affects plasminogen KO mice
| 1
STAMBP activates plasminogen KO mice. 1 / 1
| 1
reach
"The increases in BEND by acoustic startle were blunted in plasminogen-deficient mice, and central administration of BEND or AMSH increased the acoustic startle reflex in plasminogen KO mice [1189] ."
16039752
STAMBP affects phosphorylation
| 1
STAMBP inhibits phosphorylation. 1 / 1
| 1
sparser
"AMSH, OTULIN and USP2, but not Otubain-1, inhibited the phosphorylation of IκBα induced by Tax ( xref ), indicating that generation of both K63 and M1 chains is essential for Tax-induced IKK activation."
28103322
STAMBP affects mono-ubiquitin
| 1
STAMBP increases the amount of mono-ubiquitin. 1 / 1
| 1
reach
"Remarkably, AMSH produces barely detectable levels of mono-ubiquitin, but preferentially generates di-ubiquitin by a single cleavage of the tetra-ubiquitin chain (XREF_FIG a)."
15314065
STAMBP affects melanocortin-4 receptors
| 1
STAMBP activates melanocortin-4 receptors. 1 / 1
| 1
reach
"POMC neurons reduce food intake and increase energy expenditure by releasing alpha-melanocyte-stimulating hormone (aMSH), a product of POMC processing, which activates melanocortin-4 receptors (MC4R)."
22285542
STAMBP affects lung adenocarcinoma metastasis
| 1
STAMBP activates lung adenocarcinoma metastasis. 1 / 1
| 1
eidos
"STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR / MAPK signaling pathway Tumor metastasis is a leading cause of death in lung adenocarcinoma ( LUAD ) patients , but the molecular events that regulate metastasis have not been completely elucidated ."
34102455
STAMBP affects low-molecular-weight polyubiquitin chains
| 1
STAMBP decreases the amount of low-molecular-weight polyubiquitin chains. 1 / 1
| 1
reach
"AMSH treatment massively decreased the level of both high- and low-molecular-weight polyubiquitin chains on TRAF6 (corresponding to long and short polyubiquitin chains, respectively), indicating that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27746020
STAMBP activates lipopolysaccharide. 1 / 1
| 1
reach
"These findings suggest that STAMBP stabilizes NALP7 protein and is necessary for its upregulation in cells in response to LPS and Pam3CSK4."
28492230
STAMBP affects feeding
| 1
STAMBP inhibits feeding. 1 / 1
| 1
sparser
"ARC neurons processing pro-opiomelanocortin (POMC) generate not only β-endorphin, which stimulates feeding , but also ACTH and α-MSH, which inhibit feeding ."
10998540
STAMBP activates cytokine production. 1 / 1
| 1
reach
"The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome."
33253913
STAMBP affects cell membrane receptors gap junctions
| 1
STAMBP inhibits cell membrane receptors gap junctions. 1 / 1
| 1
eidos
"However , STAMBP may also induce the degradation of cell membrane receptors and gap junctions [ 16 , [ 27 ] , [ 28 ] , [ 29 ] , [ 30 ] ] ."
34102455
STAMBP activates autophagosome assembly. 1 / 1
| 1
reach
"It has also been shown that STAMBP/AMSH (STAM-binding protein) stabilizes ULK1 by removing its K48-linked ubiquitin chains and then initializes autophagosome formation [27]."
37587758
STAMBP affects activity
| 1
STAMBP inhibits activity. 1 / 1
| 1
sparser
"Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity."
28492230
STAMBP affects activated EGFR
| 1
STAMBP activates activated EGFR. 1 / 1
| 1
eidos
"Knockdown of AMSH leads to an increased degradation rate of activated EGFR ( 60 , 98 ) ."
20073038
STAMBP affects accumulation ubiquitinated protein aggregates associated autophagy receptor p62
| 1
STAMBP inhibits accumulation ubiquitinated protein aggregates associated autophagy receptor p62. 1 / 1
| 1
eidos
"An independent study observed that the loss of AMSH in neurons results in the accumulation of ubiquitinated protein aggregates associated with the autophagy receptor p62 , indicating that the autophagy flux is impaired [ 138 ] ( Figure 3D ) ."
30126257
STAMBP affects VHL
1 |
VHL binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
35205757
STAMBP affects Ubs
| 1
STAMBP binds Ubs. 1 / 1
| 1
reach
"Maybe it has to be preceded to get more information about poly- and mono-ubiquitination on specific targets in protein degradation and sorting in order to know the criteria for distinguishing ubiqutin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17078930
STAMBP affects USP7
| 1
STAMBP binds USP7. 1 / 1
| 1
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
STAMBP affects USP49
| 1
USP49 binds STAMBP. 1 / 1
| 1
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
STAMBP affects USP33
| 1
STAMBP binds USP33. 1 / 1
| 1
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
STAMBP affects USP28
1 |
USP28 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
22626734
STAMBP affects USP20
| 1
STAMBP binds USP20. 1 / 1
| 1
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
STAMBP affects UBE2S
1 |
STAMBP binds UBE2S. 1 / 1
1 |
biogrid
No evidence text available
20622874
STAMBP affects TYR
| 1
STAMBP activates TYR. 1 / 1
| 1
reach
"A-Melanocyte stimulating hormone (a-MSH) increases CAMP and tyrosinase activity in Cloudman melanoma cells."
2462505
STAMBP affects TUBA1A
| 1
COL4A1 binds MIR17HG, TUBA1A, SLC2A1, and STAMBP. 1 / 1
| 1
sparser
"Interestingly, we found several differentially expressed genes following infection with ZIKV Uganda, including COL4A1 , MIR17HG , TUBA1A , SLC2A1 and STAMBP , which are associated with microcephaly according to the comparative toxicogenomics database [ xref ]."
33121145
STAMBP affects TRIP13
1 |
STAMBP binds TRIP13. 1 / 1
1 |
biogrid
No evidence text available
19060904
STAMBP affects TP53
1 |
STAMBP binds TP53. 1 / 1
1 |
biogrid
No evidence text available
27561390
STAMBP affects TOPBP1
1 |
TOPBP1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
41524403
STAMBP affects TNFSF14
| 1
STAMBP binds TNFSF14. 1 / 1
| 1
sparser
"Significant results found only in the male stratum include negative associations of STAMBP and TNFSF14 with TCBV (β=−0.14,−0.14, see Figure  xref ), IL6 and 4E."
39282876
STAMBP affects TNFRSF1A
1 |
STAMBP binds TNFRSF1A. 1 / 1
1 |
biogrid
No evidence text available
24980434
STAMBP affects TM
| 1
STAMBP deubiquitinates TM. 1 / 1
| 1
reach
"Strikingly, co-expression of EGFR-ErbB2 TM together with AMSH D348A did not result in enhanced receptor ubiquitination, indicating that AMSH does not substantially deubiquitinate the EGFR-ErbB2 TM chi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22800866
STAMBP affects Syndrome
| 1
Mutated STAMBP activates Syndrome. 1 / 1
| 1
reach
"To the best of our knowledge, the present study reported the case of the first Chinese patient with MIC-CAP syndrome caused by a novel compound heterozygous STAMBP mutation."
31638258
STAMBP affects SPG7
1 |
SPG7 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
21988832
STAMBP affects SNCA
1 |
STAMBP binds SNCA. 1 / 1
1 |
biogrid
No evidence text available
30021006
STAMBP affects SNAI2
| 1
STAMBP increases the amount of SNAI2. 1 / 1
| 1
reach
"As shown in Fig. 3 C, STAMBP overexpression in UACC257 cells significantly induced the expression of SLUG protein at the basal level."
30454887
STAMBP affects SMAD2
1 |
SMAD2 binds STAMBP. 1 / 1
1 |
hprd
No evidence text available
14728725
STAMBP affects SMAD1
| 1
STAMBP phosphorylates SMAD1. 1 / 1
| 1
sparser
"Ectopic expression of AMSH enhanced BMP-mediated Smad1 phosphorylation, and increased BMP-induced reporter activity, growth arrest and apoptosis ( Itoh et al., 2001 )."
27155333
STAMBP affects SLC4A7
1 |
SLC4A7 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
40437099
STAMBP affects SLC2A1
| 1
COL4A1 binds MIR17HG, TUBA1A, SLC2A1, and STAMBP. 1 / 1
| 1
sparser
"Interestingly, we found several differentially expressed genes following infection with ZIKV Uganda, including COL4A1 , MIR17HG , TUBA1A , SLC2A1 and STAMBP , which are associated with microcephaly according to the comparative toxicogenomics database [ xref ]."
33121145
STAMBP affects SERPINF2
| 1
sparser
"Furthermore, Interleukin-4(IL-4), Macrophage inflammatory protein 1a(MIP-1a), and STAM binding protein(STAM-BP) were causally associated with PLI(OR:1.236, 95% CI: 1.058–1.443; OR:1.107, 95% CI: 1.008–1.214 and OR:0.759, 95% CI: 0.617–0.933)."
38429768
STAMBP affects SERBP1
1 |
SERBP1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
37223481
STAMBP affects S100A6
1 |
S100A6 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33961781
STAMBP affects RPTOR
1 |
STAMBP binds RPTOR. 1 / 1
1 |
biogrid
No evidence text available
35927303
STAMBP affects RPN11
| 1
RPN11 binds STAMBP. 1 / 1
| 1
reach
"Moreover, in structures of the eukaryotic Rpn11-Ub and AMSH-Ub complexes, but also unliganded AMSH, Ins-1 forms a short beta-hairpin and the active site is accessible XREF_BIBR, XREF_BIBR, XREF_BIBR."
30002364
STAMBP affects RNF19A
| 1
E3_Ub_ligase binds RNF19A and STAMBP. 1 / 1
| 1
sparser
"The degradation of the CaR is mediated by the ubiquitin system through interactions with the E3 ubiquitin ligase, dorfin and AMSH (Associated Molecule with the SH3 domain of STAM), a deubiqui-tinating enzyme [ xref ]."
17979874
STAMBP affects RNASEH2B
1 |
biogrid
No evidence text available
26496610
STAMBP affects RIPK2
| 1
STAMBP binds RIPK2 and Ubiquitin. 1 / 1
| 1
sparser
"Next we purified ubiquitin conjugates from L18-MDP-stimulated Mysm1 − /− BMDMs by TUBE and incubated them with recombinant MYSM1 (Rec-MYSM1) and compared the ubiquitin restriction pattern of Ub-RIP2 with that of AMSH, UCHL3, OTULIN or a combination of these three DUBs (Fig.  xref )."
30405132
STAMBP affects RECQL5
1 |
RECQL5 binds STAMBP. 1 / 1
1 |
hprd
No evidence text available
16169070
STAMBP affects RBM11
1 |
RBM11 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
35914814
STAMBP affects RB1CC1
1 |
RB1CC1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
32453962
STAMBP affects Ptpn23
1 |
Ptpn23 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
26496610
sparser
"Next, we injected nude mice with stably knocked-down STAMBP-PC cells and treated them with regular intraperitoneal injections of GEM."
39242557
STAMBP affects Pam3CSK4
| 1
STAMBP activates Pam3CSK4. 1 / 1
| 1
reach
"These findings suggest that STAMBP stabilizes NALP7 protein and is necessary for its upregulation in cells in response to LPS and Pam3CSK4."
28492230
STAMBP affects PTPN11
1 |
STAMBP binds PTPN11. 1 / 1
1 |
biogrid
No evidence text available
26344197
STAMBP affects PSMD7
1 |
PSMD7 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
26344197
STAMBP affects PRL
| 1
STAMBP inhibits PRL. 1 / 1
| 1
reach
"Thus the fetal data are also consistent with the possibility that aMSH acts via hypothalamic dopamine to suppress PRL secretion.AcknowledsementsP.D.G."
7442452
STAMBP affects PRKN
1 |
PRKN binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
35256949
STAMBP affects POMC mRNA
| 1
STAMBP decreases the amount of POMC mRNA. 1 / 1
| 1
reach
"Administration of either BEND or AMSH into the PVN, respectively, increases and decreases food intake with the latter, but not the former, altering POMC mRNA levels [224] ."
15165728
STAMBP affects PLEKHA4
1 |
PLEKHA4 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
31091453
STAMBP affects PJA1
1 |
PJA1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
22626734
STAMBP affects PAMPs
| 1
STAMBP activates PAMPs. 1 / 1
| 1
reach
"We observed a statistically significant decrease in IL-1beta secretion in cells transfected with siRNA targeting STAMBP compared to control siRNA (XREF_FIG; XREF_SUPPLEMENTARY), suggesting that STAMBP activity is necessary for normal IL-1beta maturation and release in response to the PAMPs tested."
28492230
STAMBP affects P7
| 1
P7 binds STAMBP. 1 / 1
| 1
sparser
"The mutation of K 229 by H 229 (AMSH-P7) did not alter the binding affinity of AMSH for SH3 but rather did modify its binding kinetics."
27725184
STAMBP affects OXT
| 1
STAMBP increases the amount of OXT. 1 / 1
| 1
reach
"A large body of evidence supports dendritic release to occur in an activity-dependent manner and in response to physiologically relevant stimuli, such as the release of VP triggered by an increase in plasma osmolality (Sato et al., 2011), and the release of OT induced by suckling or by the increase of melanocyte stimulating hormone (aMSH) (Bealer and Crowley, 1998; Sabatier et al., 2003; Sabatier and Leng, 2006)."
37032839
STAMBP affects NTPCR
1 |
NTPCR binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
21988832
STAMBP affects NPY
| 1
STAMBP inhibits NPY. 1 / 1
| 1
sparser
"In the present study, we also found that anorectic peptides, α-MSH and GLP-1 inhibited NPY- and orexin-induced feeding, though orexin-induced feeding was less sensitive to these peptides (Fig. 3) ."
12419401
STAMBP affects NLRP7 protein stability
| 1
STAMBP activates NLRP7 protein stability. 1 / 1
| 1
eidos
"A recent study showed that STAM-binding protein ( STAMBP ) , a deubiquitinating enzyme , modulates NLRP7 protein stability by catalyzing its deubiquitination to increase NLRP7 abundance [ 35 ] ."
33838681
STAMBP affects NFKBIA
| 1
STAMBP leads to the phosphorylation of NFKBIA. 1 / 1
| 1
reach
"AMSH, OTULIN and USP2, but not Otubain-1, inhibited the phosphorylation of IkappaBalpha induced by Tax (XREF_FIG), indicating that generation of both K63 and M1 chains is essential for Tax induced IKK activation."
28103322
STAMBP affects Monocytes
| 1
STAMBP activates Monocytes. 1 / 1
| 1
eidos
"The new findings of the study are that ( i ) STAMBP modulates inflammasome activation and IL-1beta secretion in monocytes , ( ii ) NLRP3 , through its deubiquitination by STAMBP , represents a new client for the DUB , and ( iii ) NLRP3 K-63 linked polyubiquitination triggered by STAMPB cellular depletion appears to modulate inflammasome activity but not by increasing NLRP3 protein abundance ."
33253913
STAMBP affects Macromomycin
| 1
STAMBP activates Macromomycin. 1 / 1
| 1
sparser
"Instead, we hypothesize that an in vitro interaction between MCRs and GPR139 resulted in transactivation of the phospholipase C pathway through ACTH, α-MSH, and β-MSH activation of MCRs."
29599718
STAMBP affects MYC
| 1
Mutated STAMBP decreases the amount of MYC. 1 / 1
| 1
reach
"It is of great interest that the C-terminal-half-deleted mutants of AMSH and AMSH-LP, which lack the JAMM motifs, are unable to induce the IL-2-mediated c- myc expression."
12810066
STAMBP affects MVP
| 1
STAMBP binds STAM and MVP. 1 / 1
| 1
sparser
"We wondered whether AMSH can interact simultaneously with STAM and mVps24."
16431367
STAMBP affects MVB
| 1
STAMBP binds MVB. 1 / 1
| 1
reach
"The interaction of CHMP3 with associated molecule with SH3 domain of STAM (AMSH) and recruitment of AMSH to the MVB is necessary for deubiquitination and degradation of EGFR."
19489726
STAMBP affects MTSS1
| 1
STAMBP binds MTSS1. 1 / 1
| 1
sparser
"The x-ray crystal structure of the MIT domain of AMSH bound to the C-terminal MIM fragment of the ESCRT-III member CHMP3 has been determined ( xref )."
24151880
STAMBP affects MLKL
1 |
STAMBP binds MLKL. 1 / 1
1 |
biogrid
No evidence text available
34999730
STAMBP affects MIX23
1 |
MIX23 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
26344197
STAMBP affects MITD1
| 1
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
STAMBP affects MIR17HG
| 1
COL4A1 binds MIR17HG, TUBA1A, SLC2A1, and STAMBP. 1 / 1
| 1
sparser
"Interestingly, we found several differentially expressed genes following infection with ZIKV Uganda, including COL4A1 , MIR17HG , TUBA1A , SLC2A1 and STAMBP , which are associated with microcephaly according to the comparative toxicogenomics database [ xref ]."
33121145
STAMBP affects MAP3K2
1 |
STAMBP binds MAP3K2. 1 / 1
1 |
biogrid
No evidence text available
24975362
STAMBP affects Lys63-Ub 2
| 1
STAMBP inhibits Lys63-Ub 2. 1 / 1
| 1
reach
"At this point, one can wonder if AMSH would prevent Lys63-Ub 2 from binding the UIM domain and whether Lys63-Ub 2 displays any selectivity."
27725184
STAMBP affects Lys63
| 1
STAM binds STAMBP and Lys63. 1 / 1
| 1
reach
"Interestingly, the binding of STAM with AMSH increases its activity toward Lys63-linked polyubiquitin chains [5,23] ."
27725184
LIMK2 binds Luminescent Proteins and STAMBP. 1 / 1
| 1
sparser
"Since the localization of AMSH-FPβ partly overlapped with that of tLIMK2, the possibility of functional interaction of AMSH-FP with LIMK2 could not be excluded."
12943674
STAMBP activates Latency-associated peptide. 1 / 1
| 1
reach
"STAM binding protein (STAMBP) and T-cell surface glycoprotein CD6 isoform (CD6 isoform) can increase the risk of spondylolisthesis/spondylolysis, whereas monocyte chemoattractant protein 2 (MCP2) and latency-associated peptide transforming growth factor beta 1 (LAP-TGF-beta1) can decrease spondylolisthesis/spondylolysis risk."
38895179
STAMBP affects LUAD tumor metastasis
| 1
STAMBP activates LUAD tumor metastasis. 1 / 1
| 1
eidos
"Our findings that STAMBP knockdown promotes EGFR degradation and suppresses LUAD tumor metastasis raise the possibility that targeting STAMBP may be a promising strategy to control LUAD progression ."
34102455
STAMBP affects LOC129531
| 1
STAMBP binds LOC129531. 1 / 1
| 1
reach
"Collectively data from these three different interaction studies provide strong evidence that the predicted interactions between CHMP1B and AMSH, CHMP3 and AMSH, and CHMP2A and LOC129531 may well be p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
STAMBP affects LIMK2
| 1
LIMK2 binds Luminescent Proteins and STAMBP. 1 / 1
| 1
sparser
"Since the localization of AMSH-FPβ partly overlapped with that of tLIMK2, the possibility of functional interaction of AMSH-FP with LIMK2 could not be excluded."
12943674
STAMBP affects LDB19
1 |
STAMBP binds LDB19. 1 / 1
1 |
biogrid
No evidence text available
35770973
STAMBP affects KLHL24
1 |
STAMBP binds KLHL24. 1 / 1
1 |
biogrid
No evidence text available
33961781
STAMBP affects KIF7
1 |
KIF7 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
26496610
STAMBP affects K63Ub chains
| 1
STAMBP deubiquitinates K63Ub chains. 1 / 1
| 1
reach
"AMSH, which belongs to the JAMM-domain metalloprotease family of DUBs, specifically deubiquitylates K63Ub chains."
22493318
STAMBP affects K63-linked ubiquitin chain NLRP3
| 1
STAMBP inhibits K63-linked ubiquitin chain NLRP3. 1 / 1
| 1
eidos
"The difference is that STAMBP does not affect the protein abundance of NLRP3 , but STAMBP deficiency enhances the K63-linked ubiquitin chain of NLRP3 , and the non-degraded STAMBP ubiquitination process favors NLRP3 inflammasome activation ( Bednash et al ., 2021 ) ."
34966378
STAMBP affects K63
| 1
STAMBP binds K63 and Ubiquitin. 1 / 1
| 1
sparser
"This is best illustrated by the structure obtained for a catalytically inactive variant of AMSH bound to K63-linked Ub dimer ( xref )."
22196026
STAMBP affects K11-polyUb chains
| 1
STAMBP inhibits K11-polyUb chains. 1 / 1
| 1
reach
"The addition of AMSH to the Ube2SDelta Ub reaction did not block the binding of K11-polyUb chains to the proteasome, as K11-polyUb conjugates formed using a K11-only Ub mutant (Ub K11), without the addition of AMSH, also did not bind to proteasome (XREF_SUPPLEMENTARY C)."
26190103
STAMBP affects JAMM family deubiquitinating enzyme
| 1
STAMBP deubiquitinates JAMM family deubiquitinating enzyme. 1 / 1
| 1
reach
"STAMBP is a JAMM family deubiquitinating enzyme that regulates the stability of substrate proteins in cells by cleaving the ubiquitin portion of the molecule; proteomics and other research techniques have shown that STAMBP appears to exhibit high expression in various diseases as an inflammatory biomarker, including breast cancer, ischemic stroke, and autism.45–47 However, the expression of STAMBP in diabetic retinopathy has not yet been reported.Long-term mild inflammation has been found to have a significant negative impact on the pathogenesis of diabetic neuropathy."
39712242
STAMBP affects IL2RA
| 1
STAMBP activates IL2RA. 1 / 1
| 1
reach
"STAM binding protein levels also mediated CD80 on CD62L + myeloid DC and CD25 + + CD8br %T cell at proportions of -15.4% and 7.72%."
39806364
STAMBP affects IL18
| 1
STAMBP activates IL18. 1 / 1
| 1
reach
"However, STAMBP and SIRT2 may promote IL-18 and inflammatory response through the inflammasomes NALP7 and NLRP3."
37293545
STAMBP affects IGHG2
1 |
STAMBP binds IGHG2. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBP affects I44
| 1
STAMBP binds UBD and I44. 1 / 1
| 1
reach
"Inspection of our structural model representing AMSH and diubiquitin complex reveals that the I44 patch of the distal ubiquitin is satisfied, with the Ile44 residue engaged in van der Waals interaction with Phe320; however, Ile44 of the proximal ubiquitin is unoccupied (XREF_SUPPLEMENTARY)."
24151880
STAMBP affects HRS
| 1
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
STAMBP affects HNSCC
| 1
STAMBP activates HNSCC. 1 / 1
| 1
reach
"Moreover, our findings revealed that aberrant expression of STAMBP enhanced cancer cell aggressiveness in HNSCC."
31795200
STAMBP affects GAB1
| 1
GRAP2 binds GAB1 and STAMBP. 1 / 1
| 1
sparser
"These results are consistent with previous studies showing that Gads interacts with Gab1 and AMSH in vitro [6, 10, 12] ."
12176364
STAMBP affects FlaG
| 1
STAMBP binds FlaG. 1 / 1
| 1
sparser
"Hence, we overexpressed FLAG-STAMBP WT , FLAG-STAMBP G 307 E , and FLAG-STAMBP T 313 I , a previously reported STAMBP missense variant (c."
36033615
STAMBP affects FSD1
1 |
FSD1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33961781
STAMBP affects FP
| 1
FP binds STAMBP. 1 / 1
| 1
sparser
"STAMBPL1 (also called AMSH-FP or AMSH-LP) is a member of the JAB1/MPN/MOV34 metalloenzyme (JAMM) family of zinc metalloproteases [ xref ]."
32309439
STAMBP affects FDPS
1 |
STAMBP binds FDPS. 1 / 1
1 |
biogrid
No evidence text available
22863883
STAMBP affects FCGR2A
1 |
FCGR2A binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33961781
STAMBP affects ESCRT-III
| 1
STAMBP activates ESCRT-III. 1 / 1
| 1
reach
"The gene encoding AMSH (associated molecule with a Src homology 3 domain), a deubiquitinating enzyme, was up-regulated as well as, three genes involved in the ESCRT pathway, ESCRT-0 (STAM (signal transducing adaptor molecule)) and ESCRT-III (CHMP (charged multivesicular body proteins) 2 and 4)."
29023475
STAMBP affects ESCRT-III subunits
| 1
ESCRT-III subunits binds STAMBP. 1 / 1
| 1
reach
"For example, specific ESCRT-III subunits bind more tightly to the VPS4 ATPases, the VPS4 activator Vta1p and LIP5, the adaptor protein ALIX (CHMP4A-C), and the ubiquitin hydrolases AMSH (CHMP1A and 3) and UBPY (CHMP1A, 1B, 2A, 4C, and 7)."
18606141
STAMBP affects ESCRT-III subcomplex
| 1
STAMBP binds ESCRT-III subcomplex. 1 / 1
| 1
reach
"ALIX is a conserved ESCRT-associated protein that functions in MVB formation and in Arabidopsis associates both with the ESCRT-III subcomplex, aiding cargo sorting and vesicle formation, and with the deubiquitinating enzyme AMSH, recruiting it to MVBs to recycle ubiquitin from cargo prior to degradation (5, 9)."
35700356
STAMBP affects ESCRT-III components
| 1
STAMBP binds ESCRT-III components. 1 / 1
| 1
reach
"Binding of AMSH to the ESCRT-III components is essential for targeting of AMSH to endosomes [42]."
22800866
STAMBP affects ESCRT-III complex [
| 1
STAMBP binds ESCRT-III complex [. 1 / 1
| 1
reach
"The JAMM member, AMSH, is implicated in regulating EGFR de-ubiquitination on endosomes [XREF_BIBR]; furthermore, AMSH interacts with components of the ESCRT and III complex [XREF_BIBR]."
29543760
STAMBP affects ESCRT-0 complex
| 1
STAMBP deubiquitinates ESCRT-0 complex. 1 / 1
| 1
reach
"In addition to USP9X, two other DUBs, USP8 and AMSH, bind and deubiquitinate the ESCRT-0 complex to sustain the sorting function of endosomes [15]."
37036745
STAMBP affects ESCRT subunits
| 1
STAMBP binds ESCRT subunits. 1 / 1
| 1
reach
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and -III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
STAMBP affects ESCRT III components
| 1
STAMBP binds ESCRT III components. 1 / 1
| 1
reach
"This was explained by an increased binding of DN-AMSH to ESCRT III components, preventing MIT dependent binding of the Vps4 ATPase required for disassembly of the ESCRT III complex and completion of the sorting process [XREF_BIBR]."
25396681
STAMBP affects ERK
| 1
STAMBP activates ERK. 1 / 1
| 1
reach
"Small molecule inhibitors of EGFR and MAPK signaling pathway may block STAMBP induced cell mobility and invasion as well as ERK activation in cells."
34102455
STAMBP affects EGFR-ERBB4 CYT-2 isoform
| 1
STAMBP deubiquitinates EGFR-ERBB4 CYT-2 isoform. 1 / 1
| 1
reach
"As expected, the non-K63-ubiquitinated EGFR-ERBB4 CYT-2 isoform was also not deubiquitinated by AMSH (results not shown)."
23153581
STAMBP affects EGFR-ERBB4 CYT-1
| 1
STAMBP deubiquitinates EGFR-ERBB4 CYT-1. 1 / 1
| 1
reach
"In contrast, no effect of cotransfection of AMSH D348A was observed on the level of ubiquitination of EGFR-ERBB4 CYT-1, indicating that AMSH does not substantially deubiquitinate the K63-polyubiquitin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23153581
STAMBP affects E3_Ub_ligase
| 1
E3_Ub_ligase binds RNF19A and STAMBP. 1 / 1
| 1
sparser
"The degradation of the CaR is mediated by the ubiquitin system through interactions with the E3 ubiquitin ligase, dorfin and AMSH (Associated Molecule with the SH3 domain of STAM), a deubiqui-tinating enzyme [ xref ]."
17979874
STAMBP affects Deubiquitinase
| 1
STAMBP deubiquitinates Deubiquitinase. 1 / 1
| 1
reach
"USP8 and STAMBP are two endosomal deubiquitinating (DUB) enzymes, which remove ubiquitin chains from cargo proteins to regulate the balance between receptor lysosomal degradation and recycling to plasma membrane ."
39609437
STAMBP affects DTX47
| 1
STAMBP activates DTX47. 1 / 1
| 1
reach
"In brief, to knock down gene expression only in pharyngeal muscles, we expressed the sid-1 (cDNA) under the control of the Pf53f4.13 promoter, a AMsh specific promoter in an sid-1 (pk3321) mutant background."
32209461
STAMBP affects DSCR9
1 |
DSCR9 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
35914814
STAMBP affects Chmp3
1 |
STAMBP binds Chmp3. 1 / 1
1 |
biogrid
No evidence text available
16431367
STAMBP affects CYP2C9
1 |
CYP2C9 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
21988832
STAMBP affects CXCR4 receptor
| 1
STAMBP decreases the amount of CXCR4 receptor. 1 / 1
| 1
reach
"In contrast, basal expression of the CXCR4 receptor is increased by STAMBP knockdown or inhibition, in a process dependent on STAMPB interactions with the ESCRT-0 complex XREF_BIBR."
28492230
STAMBP affects CXCL6
| 1
STAMBP binds CXCL6. 1 / 1
| 1
sparser
"In HC, PC1 and PC2 jointly account for 54.09% of the variance, with SCF, IFN-γ, CXCL9, CXCL10 and CDCP1 clustering separately from the remaining IL-6-containing set ( xref ); this bipartite structure mirrors the balanced interplay shown in xref , where a positive backbone [AXIN1–TNFSF14 (Tumor Necrosis Factor Superfamily Member 14), CXCL6–STAMBP (STAM Binding Protein), etc.] is counter-weighted by widespread negative correlations for CXCL9/CXCL10."
41624893
STAMBP affects COL4A1
| 1
COL4A1 binds MIR17HG, TUBA1A, SLC2A1, and STAMBP. 1 / 1
| 1
sparser
"Interestingly, we found several differentially expressed genes following infection with ZIKV Uganda, including COL4A1 , MIR17HG , TUBA1A , SLC2A1 and STAMBP , which are associated with microcephaly according to the comparative toxicogenomics database [ xref ]."
33121145
STAMBP affects CHMP5
1 |
CHMP5 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
21988832
STAMBP affects CHMP4C
1 |
STAMBP binds CHMP4C. 1 / 1
1 |
biogrid
No evidence text available
17711858
STAMBP affects CHMP3ΔN
| 1
CHMP3ΔN binds STAMBP. 1 / 1
| 1
sparser
"CHMP3ΔN interacts with the MIT domain of AMSH diagonal along a groove made up by helices 3 and 4/5."
21827950
STAMBP affects CHMP2B
| 1
STAMBP binds CHMP2B. 1 / 1
| 1
reach
"Because AMSH binds indirectly with CHMP2B via another ESCRT-III molecule, CHMP3 [28] , AMSH depletion and CHMP2B mutations seem to share similar pathological features."
21531206
STAMBP affects CHMP
| 1
STAMBP binds CHMP. 1 / 1
| 1
reach
"Therefore the AMSH protein was fragmented into four fragments, which were designed to assess the requirement for each domain in AMSH and CHMP protein interaction."
16730941
STAMBP affects C1QL1
| 1
STAMBP inhibits C1QL1. 1 / 1
| 1
sparser
"Β-endorphin and α-MSH inhibit CRF."
9493877
STAMBP affects C10orf88
1 |
C10orf88 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33961781
STAMBP affects BTF3
1 |
BTF3 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33644029
STAMBP affects BMPR1B
1 |
BMPR1B binds STAMBP. 1 / 1
1 |
hprd
No evidence text available
11483516
STAMBP affects BAG3
| 1
STAMBP binds BAG3. 1 / 1
| 1
sparser
"Mechanistically, STAMBP interacts with BAG3 and promotes its stabilization by removing its K63-linked polyubiquitin chains."
41611844
STAMBP activates Antigen-Presenting Cells. 1 / 1
| 1
sparser
"This is mediated by α-MSH, neuropeptide Y, and TGF-β2 that activate suppressive APC, and antigen-activated Treg cells."
26904026
STAMBP activates Ala-Pro zwitterion. 1 / 1
| 1
reach
"The role of STAMBP in promoting AP has not been directly reported previously, and the detailed mechanisms underlying its involvement warrant further investigation."
39774240
STAMBP affects ATPase
| 1
STAMBP bound to ESCRT III components inhibits ATPase. 1 / 1
| 1
reach
"This was explained by an increased binding of DN-AMSH to ESCRT III components, preventing MIT dependent binding of the Vps4 ATPase required for disassembly of the ESCRT III complex and completion of the sorting process [XREF_BIBR]."
25396681
STAMBP affects ATG13
1 |
ATG13 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
32453962
STAMBP affects AMSH2
| 1
STAMBP binds AMSH2 and SMAD. 1 / 1
| 1
sparser
"For example, TIEG and Foxp3 enhance TGF-β signaling through the repression of Smad7 gene expression ( xref , xref ), AMSH and AMSH2 interact with inhibitory Smads and suppress their effects ( xref , xref ), and Jab1/CSN5 induce Smad7 degradation ( xref )."
21795712
STAMBP affects ADCY
| 1
STAMBP bound to MC1R activates ADCY. 1 / 1
| 1
reach
"[5] a-Melanocyte stimulating hormone (a-MSH), which binds to MSH-R, a G protein coupled receptor also known as the melanocortin-1 receptor (MC1-R) [6] activates AC, thereby increasing the amount of cAMP in the cell."
12503631
STAMBP activates 3-methylcholanthrene. 1 / 1
| 1
sparser
"The sensor components of this system are MC 3 R and MC 4 R activated by α-MSH and other peptides of the melanocortin family that are generated as a result of proteolytic cleavage of POMC."
28031898
STAMBP affects 3',5'-cyclic AMP
| 1
STAMBP activates 3',5'-cyclic AMP. 1 / 1
| 1
reach
"The second effect is a synergic action forming cAMP induced by the aMSH."
8801543
STAM affects snf7
| 1
STAMBP binds STAM and snf7. 1 / 1
| 1
sparser
"Recent studies showed that AMSH binds to the ESCRT-III complex in a STAM-independent manner ( xref ; xref ), in support of the suggestion that AMSH might be a counterpart of Doa4p ( xref )."
17660439
STAM affects MVP
| 1
STAMBP binds STAM and MVP. 1 / 1
| 1
sparser
"We wondered whether AMSH can interact simultaneously with STAM and mVps24."
16431367
STAM affects Lys63
| 1
STAM binds STAMBP and Lys63. 1 / 1
| 1
reach
"Interestingly, the binding of STAM with AMSH increases its activity toward Lys63-linked polyubiquitin chains [5,23] ."
27725184
STAM affects HRS
| 1
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
SPG7 affects STAMBP
1 |
SPG7 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
21988832
SP.1 affects STAMBP
| 1
SP.1 inhibits STAMBP. 1 / 1
| 1
reach
"Both UbV SP.1 and UbV SP.3 potently inhibited the isopeptidase activity of STAMBP JAMM (Fig. 5B ) and full-length STAMBP (Fig. 5C ) towards the cleavage of K63-linked poly-Ub chains."
| DOI
SOCS1 affects STAMBP
| 1
SOCS1 inhibits STAMBP. 1 / 1
| 1
reach
"SOCS1 poly-ubiquitin signal decreased following treatment with AMSH, suggesting SOCS1 contains K63-linked poly-ubiquitin chains."
36938956
SNCA affects STAMBP
1 |
STAMBP binds SNCA. 1 / 1
1 |
biogrid
No evidence text available
30021006
SNAI2 affects STAMBP
| 1
SNAI2 activates STAMBP. 1 / 1
| 1
reach
"By transfecting STAMBP siRNA, the protein levels of SLUG were significantly reduced in both SK-MEL-28 and UACC257 cells ( Fig. 3 A)."
30454887
SMAD2 affects STAMBP
1 |
SMAD2 binds STAMBP. 1 / 1
1 |
hprd
No evidence text available
14728725
SMAD affects AMSH2
| 1
STAMBP binds AMSH2 and SMAD. 1 / 1
| 1
sparser
"For example, TIEG and Foxp3 enhance TGF-β signaling through the repression of Smad7 gene expression ( xref , xref ), AMSH and AMSH2 interact with inhibitory Smads and suppress their effects ( xref , xref ), and Jab1/CSN5 induce Smad7 degradation ( xref )."
21795712
SLC4A7 affects STAMBP
1 |
SLC4A7 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
40437099
SLC2A1 affects TUBA1A
| 1
COL4A1 binds MIR17HG, TUBA1A, SLC2A1, and STAMBP. 1 / 1
| 1
sparser
"Interestingly, we found several differentially expressed genes following infection with ZIKV Uganda, including COL4A1 , MIR17HG , TUBA1A , SLC2A1 and STAMBP , which are associated with microcephaly according to the comparative toxicogenomics database [ xref ]."
33121145
SERPINF2 affects STAMBP
| 1
sparser
"Furthermore, Interleukin-4(IL-4), Macrophage inflammatory protein 1a(MIP-1a), and STAM binding protein(STAM-BP) were causally associated with PLI(OR:1.236, 95% CI: 1.058–1.443; OR:1.107, 95% CI: 1.008–1.214 and OR:0.759, 95% CI: 0.617–0.933)."
38429768
SERBP1 affects STAMBP
1 |
SERBP1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
37223481
S100A6 affects STAMBP
1 |
S100A6 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33961781
RPTOR affects STAMBP
1 |
STAMBP binds RPTOR. 1 / 1
1 |
biogrid
No evidence text available
35927303
RPN11 affects STAMBP
| 1
RPN11 binds STAMBP. 1 / 1
| 1
reach
"Moreover, in structures of the eukaryotic Rpn11-Ub and AMSH-Ub complexes, but also unliganded AMSH, Ins-1 forms a short beta-hairpin and the active site is accessible XREF_BIBR, XREF_BIBR, XREF_BIBR."
30002364
RNF19A affects STAMBP
| 1
E3_Ub_ligase binds RNF19A and STAMBP. 1 / 1
| 1
sparser
"The degradation of the CaR is mediated by the ubiquitin system through interactions with the E3 ubiquitin ligase, dorfin and AMSH (Associated Molecule with the SH3 domain of STAM), a deubiqui-tinating enzyme [ xref ]."
17979874
RNF11 affects EPS15
| 1
RNF11 binds EPS15 and STAMBP. 1 / 1
| 1
sparser
"We found that RNF11 associates with EPS-15 and AMSH, which is the molecule associated with the SH3 domain of STAM (AMSH)."
16925951
RNAi affects STAMBP
| 1
RNAi inhibits STAMBP. 1 / 1
| 1
reach
"Loss of AMSH catalytic activity or depletion by RNAi results in increased steady-state levels of CXCR4 under basal conditions."
20159979
RNASEH2B affects STAMBP
1 |
biogrid
No evidence text available
26496610
RIPK2 affects Ubiquitin
| 1
STAMBP binds RIPK2 and Ubiquitin. 1 / 1
| 1
sparser
"Next we purified ubiquitin conjugates from L18-MDP-stimulated Mysm1 − /− BMDMs by TUBE and incubated them with recombinant MYSM1 (Rec-MYSM1) and compared the ubiquitin restriction pattern of Ub-RIP2 with that of AMSH, UCHL3, OTULIN or a combination of these three DUBs (Fig.  xref )."
30405132
RECQL5 affects STAMBP
1 |
RECQL5 binds STAMBP. 1 / 1
1 |
hprd
No evidence text available
16169070
RBM11 affects STAMBP
1 |
RBM11 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
35914814
RB1CC1 affects STAMBP
1 |
RB1CC1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
32453962
Ptpn23 affects STAMBP
1 |
Ptpn23 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
26496610
Proteasome affects STAMBP
| 1
Proteasome inhibits STAMBP. 1 / 1
| 1
reach
"These three JAMM domain DUBs are : Rpn11 in yeast (POH1 in humans) XREF_BIBR - XREF_BIBR, a subunit of the proteasome that cleaves ubiquitin chains from substrate proteins that are being degraded by the proteasome; CSN5, a subunit of the COP9 signalosome XREF_BIBR which cleaves Nedd8 (Neural Precursor Cell Expressed, Developmentally Down-regulated 8, a ubiquitin like protein) conjugates; and AMSH (associated molecule with the SH3 domain of STAM) a deubiquitinating enzyme involved in endocytosis XREF_BIBR."
19243136
Piwil1 affects STAMBP
| 1
Piwil1 inhibits STAMBP. 1 / 1
| 1
reach
"In response to such alterations in the piRNA population, mRNAs encoding Prelid1, Stambp, and Tex101, which are negatively regulated by MIWI-bound pachytene cluster piRNAs , are upregulated in Adad2 testes (Figure 3A and S4B)."
36698249
sparser
"Next, we injected nude mice with stably knocked-down STAMBP-PC cells and treated them with regular intraperitoneal injections of GEM."
39242557
PTPN11 affects STAMBP
1 |
STAMBP binds PTPN11. 1 / 1
1 |
biogrid
No evidence text available
26344197
PSMD7 affects STAMBP
1 |
PSMD7 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
26344197
PSMD14 affects STAMBP
| 1
PSMD14 activates STAMBP. 1 / 1
| 1
reach
"Therefore, a second process involving DUBs is the recycling of ubiquitin by preventing its degradation, which is mediated by proteasome associated DUBs USP14, UCH-L5 and UCH37, and POH1, or receptor mediated endocytosis and lysosomal degradation associated DUBs USP8 and AMSH."
27516771
PRKN affects STAMBP
1 |
PRKN binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
35256949
PLEKHA4 affects STAMBP
1 |
PLEKHA4 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
31091453
PJA1 affects STAMBP
1 |
PJA1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
22626734
PF 3758309 affects STAMBP
1 |
PF 3758309 decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
29048629
PCBP1 affects STAMBP
1 |
PCBP1 decreases the amount of STAMBP. 1 / 1
1 |
biopax:msigdb
No evidence text available
P7 affects STAMBP
| 1
P7 binds STAMBP. 1 / 1
| 1
sparser
"The mutation of K 229 by H 229 (AMSH-P7) did not alter the binding affinity of AMSH for SH3 but rather did modify its binding kinetics."
27725184
NTPCR affects STAMBP
1 |
NTPCR binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
21988832
NLRP7 affects Ubiquitin
| 1
NLRP7 binds Ubiquitin and STAMBP. 1 / 1
| 1
sparser
"Further, we introduce the small molecule BC-1471, which interrupts STAMBP-Ub-NALP7 interaction and suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, peripheral blood mononuclear cells and lung organ culture."
28492230
MVP affects STAMBP
| 1
STAMBP binds STAM and MVP. 1 / 1
| 1
sparser
"We wondered whether AMSH can interact simultaneously with STAM and mVps24."
16431367
MVB affects STAMBP
| 1
STAMBP binds MVB. 1 / 1
| 1
reach
"The interaction of CHMP3 with associated molecule with SH3 domain of STAM (AMSH) and recruitment of AMSH to the MVB is necessary for deubiquitination and degradation of EGFR."
19489726
MTSS1 affects STAMBP
| 1
STAMBP binds MTSS1. 1 / 1
| 1
sparser
"The x-ray crystal structure of the MIT domain of AMSH bound to the C-terminal MIM fragment of the ESCRT-III member CHMP3 has been determined ( xref )."
24151880
MLKL affects STAMBP
1 |
STAMBP binds MLKL. 1 / 1
1 |
biogrid
No evidence text available
34999730
MIX23 affects STAMBP
1 |
MIX23 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
26344197
MITD1 affects USP8
| 1
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
MIT domain affects CHMP3
| 1
STAMBP binds CHMP3 and MIT domain. 1 / 1
| 1
reach
"This suggests that the AMSH MIT domain interaction with CHMP3 differs substantially from the low-affinity Vps4 MIT domain interaction."
18395747
MIT domain affects CHMP1A
| 1
STAMBP binds CHMP1A and MIT domain. 1 / 1
| 1
reach
"The AMSH MIT domain binds to CHMP1A, 1B, and 3 by multiple reports."
21332354
MIR613 affects STAMBP
1 |
MIR613 decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
MIR206 affects STAMBP
1 |
MIR206 decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
MIR190B affects STAMBP
1 |
MIR190B decreases the amount of STAMBP. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
MIR17HG affects TUBA1A
| 1
COL4A1 binds MIR17HG, TUBA1A, SLC2A1, and STAMBP. 1 / 1
| 1
sparser
"Interestingly, we found several differentially expressed genes following infection with ZIKV Uganda, including COL4A1 , MIR17HG , TUBA1A , SLC2A1 and STAMBP , which are associated with microcephaly according to the comparative toxicogenomics database [ xref ]."
33121145
MAP3K2 affects STAMBP
1 |
STAMBP binds MAP3K2. 1 / 1
1 |
biogrid
No evidence text available
24975362
M affects STAMBP
| 1
M activates STAMBP. 1 / 1
| 1
reach
"-10 -9 -8 -7 -6 -5 -4 log (M) that, in contrast to MCH, did not cross- react with the a-MSH antiserum, induced a significant stimulation of the aMSH release at concentrations of 10 and 35 pM."
7479340
Lys63 affects STAMBP
| 1
STAM binds STAMBP and Lys63. 1 / 1
| 1
reach
"Interestingly, the binding of STAM with AMSH increases its activity toward Lys63-linked polyubiquitin chains [5,23] ."
27725184
LIMK2 binds Luminescent Proteins and STAMBP. 1 / 1
| 1
sparser
"Since the localization of AMSH-FPβ partly overlapped with that of tLIMK2, the possibility of functional interaction of AMSH-FP with LIMK2 could not be excluded."
12943674
LOC129531 affects STAMBP
| 1
STAMBP binds LOC129531. 1 / 1
| 1
reach
"Collectively data from these three different interaction studies provide strong evidence that the predicted interactions between CHMP1B and AMSH, CHMP3 and AMSH, and CHMP2A and LOC129531 may well be p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16730941
LIMK2 affects STAMBP
| 1
LIMK2 binds Luminescent Proteins and STAMBP. 1 / 1
| 1
sparser
"Since the localization of AMSH-FPβ partly overlapped with that of tLIMK2, the possibility of functional interaction of AMSH-FP with LIMK2 could not be excluded."
12943674
LEP affects STAMBP
| 1
LEP increases the amount of STAMBP. 1 / 1
| 1
reach
"Stimulation of leptin receptors in the ventromedial hypothalamus triggered the release of aMSH."
16102938
LDB19 affects STAMBP
1 |
STAMBP binds LDB19. 1 / 1
1 |
biogrid
No evidence text available
35770973
KLHL24 affects STAMBP
1 |
STAMBP binds KLHL24. 1 / 1
1 |
biogrid
No evidence text available
33961781
KIF7 affects STAMBP
1 |
KIF7 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
26496610
KIF17 affects STAMBP
| 1
KIF17 activates STAMBP. 1 / 1
| 1
eidos
"As predicted , osm-3 ( p802 ) promoted ectocytosis of GCY-22-GFP towards AMsh ( Figure 4G ) ."
34533135
K63 affects Ubiquitin
| 1
STAMBP binds K63 and Ubiquitin. 1 / 1
| 1
sparser
"This is best illustrated by the structure obtained for a catalytically inactive variant of AMSH bound to K63-linked Ub dimer ( xref )."
22196026
IGHG2 affects STAMBP
1 |
STAMBP binds IGHG2. 1 / 1
1 |
biogrid
No evidence text available
28514442
I44 affects UBD
| 1
STAMBP binds UBD and I44. 1 / 1
| 1
reach
"Inspection of our structural model representing AMSH and diubiquitin complex reveals that the I44 patch of the distal ubiquitin is satisfied, with the Ile44 residue engaged in van der Waals interaction with Phe320; however, Ile44 of the proximal ubiquitin is unoccupied (XREF_SUPPLEMENTARY)."
24151880
HRS affects USP8
| 1
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
HGS affects USP8
| 1
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
HGS affects STAM, and STAMBP
| 1
STAM binds HGS and STAMBP. 1 / 1
| 1
reach
"Thus, the STAM, Hrs, and AMSH complex may engage in a tripartite interaction with clathrin, embedding it within the endosomal coat structure.Hrs serves to recruit downstream components of the MVB sort[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
Gly-Gln affects STAMBP
| 1
Gly-Gln inhibits STAMBP. 1 / 1
| 1
reach
"RESULTS Glycyl-L-glutamine inhibited the thermogenic effect of aMSH when the two peptides were coinjected into previously identified PGEZ- and a-MSH-responsive thermoregulatory injection sites in the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8284272
GRAP2 affects GAB1
| 1
GRAP2 binds GAB1 and STAMBP. 1 / 1
| 1
sparser
"These results are consistent with previous studies showing that Gads interacts with Gab1 and AMSH in vitro [6, 10, 12] ."
12176364
GRAMD1B affects STAMBP
| 1
GRAMD1B inhibits STAMBP. 1 / 1
| 1
reach
"Finally, we found that carriers of the GRAMD1B allele had decreased serum concentrations of STAMBP protein (P = 0.00033; Fig. 1E), a key protein involved in the control of autophagy flux and the NLRP3 inflammasome."
35581176
GOT1 affects STAMBP
| 1
GOT1 activates STAMBP. 1 / 1
| 1
reach
"As the expression of the human eas-1 homolog, GOLT1B, can rescue the enlarged AMsh phenotypes in eas-1 mutants, the findings we reported here are likely to be an evolutionarily conserved mechanism of glial size regulation."
33370778
GABAb receptors affects STAMBP
| 1
GABAb receptors inhibits STAMBP. 1 / 1
| 1
reach
"Activation of the GABAb receptors by baclofen also induced inhibition of cAMP production and aMSH secretion."
3033416
GAB1 affects STAMBP
| 1
GRAP2 binds GAB1 and STAMBP. 1 / 1
| 1
sparser
"These results are consistent with previous studies showing that Gads interacts with Gab1 and AMSH in vitro [6, 10, 12] ."
12176364
FlaG affects STAMBP
| 1
STAMBP binds FlaG. 1 / 1
| 1
sparser
"Hence, we overexpressed FLAG-STAMBP WT , FLAG-STAMBP G 307 E , and FLAG-STAMBP T 313 I , a previously reported STAMBP missense variant (c."
36033615
FSD1 affects STAMBP
1 |
FSD1 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33961781
FR900359 affects STAMBP
1 |
FR900359 phosphorylates STAMBP. 1 / 1
1 |
ctd
No evidence text available
37730182
FP affects STAMBP
| 1
FP binds STAMBP. 1 / 1
| 1
sparser
"STAMBPL1 (also called AMSH-FP or AMSH-LP) is a member of the JAB1/MPN/MOV34 metalloenzyme (JAMM) family of zinc metalloproteases [ xref ]."
32309439
FDPS affects STAMBP
1 |
STAMBP binds FDPS. 1 / 1
1 |
biogrid
No evidence text available
22863883
FCGR2A affects STAMBP
1 |
FCGR2A binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33961781
ESCRT-III subunits affects STAMBP
| 1
ESCRT-III subunits binds STAMBP. 1 / 1
| 1
reach
"For example, specific ESCRT-III subunits bind more tightly to the VPS4 ATPases, the VPS4 activator Vta1p and LIP5, the adaptor protein ALIX (CHMP4A-C), and the ubiquitin hydrolases AMSH (CHMP1A and 3) and UBPY (CHMP1A, 1B, 2A, 4C, and 7)."
18606141
ESCRT-III subcomplex affects STAMBP
| 1
STAMBP binds ESCRT-III subcomplex. 1 / 1
| 1
reach
"ALIX is a conserved ESCRT-associated protein that functions in MVB formation and in Arabidopsis associates both with the ESCRT-III subcomplex, aiding cargo sorting and vesicle formation, and with the deubiquitinating enzyme AMSH, recruiting it to MVBs to recycle ubiquitin from cargo prior to degradation (5, 9)."
35700356
ESCRT-III components affects STAMBP
| 1
STAMBP binds ESCRT-III components. 1 / 1
| 1
reach
"Binding of AMSH to the ESCRT-III components is essential for targeting of AMSH to endosomes [42]."
22800866
ESCRT-III complex [ affects STAMBP
| 1
STAMBP binds ESCRT-III complex [. 1 / 1
| 1
reach
"The JAMM member, AMSH, is implicated in regulating EGFR de-ubiquitination on endosomes [XREF_BIBR]; furthermore, AMSH interacts with components of the ESCRT and III complex [XREF_BIBR]."
29543760
ESCRT subunits affects STAMBP
| 1
STAMBP binds ESCRT subunits. 1 / 1
| 1
reach
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and -III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
ESCRT III components affects STAMBP
| 1
STAMBP binds ESCRT III components. 1 / 1
| 1
reach
"This was explained by an increased binding of DN-AMSH to ESCRT III components, preventing MIT dependent binding of the Vps4 ATPase required for disassembly of the ESCRT III complex and completion of the sorting process [XREF_BIBR]."
25396681
EPS15 affects RNF11, and STAMBP
| 1
RNF11 binds EPS15 and STAMBP. 1 / 1
| 1
sparser
"We found that RNF11 associates with EPS-15 and AMSH, which is the molecule associated with the SH3 domain of STAM (AMSH)."
16925951
E4F1 affects STAMBP
1 |
E4F1 decreases the amount of STAMBP. 1 / 1
1 |
biopax:msigdb
No evidence text available
E3_Ub_ligase affects RNF19A, and STAMBP
| 1
E3_Ub_ligase binds RNF19A and STAMBP. 1 / 1
| 1
sparser
"The degradation of the CaR is mediated by the ubiquitin system through interactions with the E3 ubiquitin ligase, dorfin and AMSH (Associated Molecule with the SH3 domain of STAM), a deubiqui-tinating enzyme [ xref ]."
17979874
Deubiquitinase affects STAMBP
| 1
Deubiquitinase activates STAMBP. 1 / 1
| 1
reach
"We propose that STAM fulfills an adaptor function for AMSH and that there might be a correspondingly diverse set of DUB and adaptor combinations.The ability of STAM to directly stimulate AMSH activity[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
DUB AMSH affects STAMBP
| 1
DUB AMSH deubiquitinates STAMBP. 1 / 1
| 1
reach
"The endosome-associated DUB AMSH can also deubiquitinate the EGFR and loss of AMSH enhances degradation of the activated EGFR [75] ."
16406635
DSCR9 affects STAMBP
1 |
DSCR9 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
35914814
DGS1 affects STAMBP
| 1
DGS1 activates STAMBP. 1 / 1
| 1
reach
"Together, our data demonstrate that DGS-1 functions in the cilia of six amphid sensory neurons to signal the presence of intact dendrite cilia to the surrounding AMsh glial cell."
39747235
Clathrin affects STAMBPL1
| 1
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
Chmp3 affects STAMBP
1 |
STAMBP binds Chmp3. 1 / 1
1 |
biogrid
No evidence text available
16431367
Chemokine affects STAMBP
| 1
Chemokine activates STAMBP. 1 / 1
| 1
reach
"As expected, transcript expression of all assayed cytokines and chemokines increased in both the STAMBP and Cas9 cells with endotoxin exposure."
33253913
Capzimin affects STAMBP
| 1
Capzimin inhibits STAMBP. 1 / 1
| 1
reach
"Capzimin, a quinoline-8-thiol (8TQ) derivative targets the active site zinc of proteasomal subunit Rpn11, but also inhibits BRCC36 and AMSH ."
39282282
CYP2C9 affects STAMBP
1 |
CYP2C9 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
21988832
CXCL6 affects STAMBP
| 1
STAMBP binds CXCL6. 1 / 1
| 1
sparser
"In HC, PC1 and PC2 jointly account for 54.09% of the variance, with SCF, IFN-γ, CXCL9, CXCL10 and CDCP1 clustering separately from the remaining IL-6-containing set ( xref ); this bipartite structure mirrors the balanced interplay shown in xref , where a positive backbone [AXIN1–TNFSF14 (Tumor Necrosis Factor Superfamily Member 14), CXCL6–STAMBP (STAM Binding Protein), etc.] is counter-weighted by widespread negative correlations for CXCL9/CXCL10."
41624893
COL4A1 affects TUBA1A
| 1
COL4A1 binds MIR17HG, TUBA1A, SLC2A1, and STAMBP. 1 / 1
| 1
sparser
"Interestingly, we found several differentially expressed genes following infection with ZIKV Uganda, including COL4A1 , MIR17HG , TUBA1A , SLC2A1 and STAMBP , which are associated with microcephaly according to the comparative toxicogenomics database [ xref ]."
33121145
CLTC affects STAMBPL1
| 1
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
CHMP5 affects STAMBP
1 |
CHMP5 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
21988832
CHMP4C affects STAMBP
1 |
STAMBP binds CHMP4C. 1 / 1
1 |
biogrid
No evidence text available
17711858
CHMP4B affects USP8
| 1
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
CHMP4A affects CHMP4B, MITD1, RAD51B, STAMBP, USP8, and chmp4
| 1
Chmp4 binds RAD51B, CHMP4A, CHMP4B, MITD1, USP8, and STAMBP. 1 / 1
| 1
sparser
"This was surprising, particularly as MITD1, USP8, and AMSH all bound the other two CHMP4 paralogs, CHMP4A and CHMP4B ( xref )."
36107470
CHMP3ΔN affects STAMBP
| 1
CHMP3ΔN binds STAMBP. 1 / 1
| 1
sparser
"CHMP3ΔN interacts with the MIT domain of AMSH diagonal along a groove made up by helices 3 and 4/5."
21827950
CHMP3 affects USP8
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP3 affects MIT domain, and STAMBP
| 1
STAMBP binds CHMP3 and MIT domain. 1 / 1
| 1
reach
"This suggests that the AMSH MIT domain interaction with CHMP3 differs substantially from the low-affinity Vps4 MIT domain interaction."
18395747
CHMP3 affects CHMP2A
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP2B affects STAMBP
| 1
STAMBP binds CHMP2B. 1 / 1
| 1
reach
"Because AMSH binds indirectly with CHMP2B via another ESCRT-III molecule, CHMP3 [28] , AMSH depletion and CHMP2B mutations seem to share similar pathological features."
21531206
CHMP2A affects USP8
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP1B affects USP8
1 |
USP8 binds STAMBP and CHMP1B. 1 / 1
1 |
hprd
No evidence text available
17711858
CHMP1B affects CHMP1A
| 1
STAMBP binds CHMP1A and CHMP1B. 1 / 1
| 1
sparser
"Accordingly SPR measurements showed a much lower affinity for CHMP1A and CHMP1B interaction with AMSH ( xref )."
21827950
CHMP1A affects USP8
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP1A affects MIT domain, and STAMBP
| 1
STAMBP binds CHMP1A and MIT domain. 1 / 1
| 1
reach
"The AMSH MIT domain binds to CHMP1A, 1B, and 3 by multiple reports."
21332354
CHMP1A affects CHMP3
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP1A affects CHMP1B, and STAMBP
| 1
STAMBP binds CHMP1A and CHMP1B. 1 / 1
| 1
sparser
"Accordingly SPR measurements showed a much lower affinity for CHMP1A and CHMP1B interaction with AMSH ( xref )."
21827950
CHMP affects STAMBP
| 1
STAMBP binds CHMP. 1 / 1
| 1
reach
"Therefore the AMSH protein was fragmented into four fragments, which were designed to assess the requirement for each domain in AMSH and CHMP protein interaction."
16730941
CHEMBL4096289 affects STAMBP
1 |
CHEMBL4096289 inhibits STAMBP. 1 / 1
1 |
tas
No evidence text available
28191850
CHEMBL4095913 affects STAMBP
1 |
CHEMBL4095913 inhibits STAMBP. 1 / 1
1 |
tas
No evidence text available
28191850
CHEMBL4080490 affects STAMBP
1 |
CHEMBL4080490 inhibits STAMBP. 1 / 1
1 |
tas
No evidence text available
28191850
CHEMBL4060337 affects STAMBP
1 |
CHEMBL4060337 inhibits STAMBP. 1 / 1
1 |
tas
No evidence text available
28191850
C1QL1 affects STAMBP
| 1
C1QL1 increases the amount of STAMBP. 1 / 1
| 1
reach
"Relative rates of acetylated BEND and AMSH release following CRF stimulation in the common carp in vitro match plasma level changes in vivo [1218] ."
16973239
C10orf88 affects STAMBP
1 |
C10orf88 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33961781
BTF3 affects STAMBP
1 |
BTF3 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
33644029
BMP affects STAMBP
| 1
BMP activates STAMBP. 1 / 1
| 1
reach
"By binding to and sequestering Smad6, an ' inhibitory Smad ' and an antagonist of the BMP-Smad pathway, AMSH seems to be able to positively regulate BMP induced responses.The involvement of AMSH in va[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11728436
BAG3 affects STAMBP
| 1
STAMBP binds BAG3. 1 / 1
| 1
sparser
"Mechanistically, STAMBP interacts with BAG3 and promotes its stabilization by removing its K63-linked polyubiquitin chains."
41611844
Asbestos, Serpentine increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
21148743
AVP affects USP8
| 1
USP8 binds STAMBP and AVP. 1 / 1
| 1
sparser
"Like Doa4 in yeast, mammalian Usp8 and AMSH associate with class E Vps proteins on endosomes."
19489724
ATG7 affects STAMBP
| 1
ATG7 inhibits STAMBP. 1 / 1
| 1
reach
"Similar reductions in aMSH fiber density were also observed in the DMH and LHA (XREF_SUPPLEMENTARY), indicating that Atg7 deficiency causes extensive disruption of aMSH projections to each of their major terminal fields."
22285542
ATG13 affects STAMBP
1 |
ATG13 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
32453962
AMSH2 affects STAMBP
| 1
STAMBP binds AMSH2 and SMAD. 1 / 1
| 1
sparser
"For example, TIEG and Foxp3 enhance TGF-β signaling through the repression of Smad7 gene expression ( xref , xref ), AMSH and AMSH2 interact with inhibitory Smads and suppress their effects ( xref , xref ), and Jab1/CSN5 induce Smad7 degradation ( xref )."
21795712
6-propyl-2-thiouracil decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
24780913
3-chloropropane-1,2-diol increases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
34915118
1,3-dinitrobenzene decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
21983209
['^Ijiodosulpiride binding sites affects STAMBP
| 1
['^Ijiodosulpiride binding sites activates STAMBP. 1 / 1
| 1
reach
"These observations are in good agreement with the presence of specific [' ^ Ijiodosulpiride binding sites in the IL at E20 (Sales et al., 1989), and with the DA inhibi- tion of the CRF stimulated aMSH[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7821719
4,4'-sulfonyldiphenol decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
36041667
4,4'-diaminodiphenylmethane decreases the amount of STAMBP. 1 / 1
1 |
ctd
No evidence text available
18648102