IndraLab

Statements

PAN3 affects PAN2
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PAN3 binds PAN2.
4 2 | 125 86
PAN2 binds PAN3. 10 / 203
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"Deadenylation is triggered by deadenylases, which include the CCR4 and NOT complex, the PAN2 and PAN3 complex and PARN in mammals."
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"A previous study using Pan3 mutants defective in dimerization suggested that a single Pan3 chain could bind Pan2 (Christie etal, 2013)."
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"Moreover, interactions between eIF4G and the poly [A] binding protein Pab1 are capable of mediating interactions between the 5 ' and 3 ' ends of mRNA [XREF_BIBR], whereby Pab1 stimulates both translation initiation [XREF_BIBR, XREF_BIBR] and deadenylation by the Pan2 and Pan3 complex [XREF_BIBR]."
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"Furthermore, these results are consistent with previous observations indicating that the CCR4, CAF1, and NOT complex takes over cytoplasmic deadenylation in the absence of the PAN2 and PAN3 complex (T[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these data demonstrate that Cid1 and Ccr4, but neither the Pan2 and Pan3 complex nor PARN, are important for mRNA decay, as judged by the increased stability of urg1 transcripts in the corresponding deletion strains."
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"The role of the PAN2 and PAN3 complex in silencing was also analyzed by determining the effects of PAN3 and NOT1 depletion on silencing that was mediated directly by tethering the GW182 protein."
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"Two protein complexes account for the major cytoplasmic deadenylation activities in eukaryotes: Pan2-Pan3 and Ccr4-Not ( xref )."
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"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly (A) nucleases, respectively, their in vivo roles in mammalian mRNA turnover remain unclear."
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"POP2, like PARN and PAN2, the catalytic subunit of the Pan2 and Pan3 complex, is a member of the DEDD nuclease family."
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"However, it is still possible that the PAN2 and PAN3 complex may be important for the silencing of a subset of miRNA targets.Thus far, our data indicate that GW182 proteins recruit deadenylase complex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21981923
CNOT7 binds PAN2, PAN3, and ccr4. 6 / 6
| 6
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"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
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"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
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"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"It appears that these two proteins do not directly interact with Pan2-Pan3 or the Ccr4-Caf1 deadenylase complex."
19838187
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"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
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"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
PKC binds PAN2 and PAN3. 1 / 1
| 1
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"When we tested the interaction of the ct Pan2–Pan3 PKC complex with polyA RNA, the binding was comparable to ct Pan3 PKC alone (Fig  xref B)."
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PAN2 binds PAN3 and ccr4. 1 / 1
| 1
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"Interestingly, interactions between Pan2-Pan3 and Ccr4-Not can be detected suggesting that both deadenylase complexes can reside in a higher order complex that may include other components ( xref )."
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PAN2 binds MARF1 and PAN3. 1 / 1
| 1
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"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
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PAN2 binds PAN3, exonuclease, and ccr4. 1 / 1
| 1
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"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN2 binds PAN3 and MTA2. 1 / 1
| 1
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"In summary, we found that it was difficult to disrupt the Pan2–Pan3 interaction by deletion of substantial regions of ct Pan2 PID and show that a core region (residues 343–406) makes a major contribution to the association of ct Pan2 and ct Pan3."
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PAN2 binds PAN3 and PABPC1. 1 / 1
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No evidence text available
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RNPC3 binds PAN2 and PAN3. 1 / 1
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"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
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CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
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"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN3 inhibits PAN2.
| 1
PAN3 inhibits PAN2. 1 / 2
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"It is therefore a possibility that PAN3 depletion prevents USP52 localization to P-bodies and thus contributes to the destabilization of AMD substrates, as we have observed in the case of HIF1A."
23398456
PAN3 activates PAN2.
| 2
PAN3 activates PAN2. 2 / 2
| 2
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"Because Pan3 is able to enhance localization of Pan2 to P-bodies (XREF_FIG), we then tested whether Pan3 also helps Ccr4 and Caf1 localize to P-bodies."
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"Instead, Pan3 may modulate the activity of Pan2 poly (A) nuclease or link deadenylation to subsequent decay of the mRNA body."
18625844
PAN2 affects ASF1A
1 1 | 23 13
PAN2 binds ASF1A.
1 | 2 13
PAN2 binds ASF1A. 10 / 16
1 | 2 13
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"Histone chaperone ASF1A is physically associated with USP52."
29599486
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"To confirm the in vivo association of ASF1A with USP52, co-immunoprecipitation experiments were performed and the results showed that USP52 was efficiently co-immunoprecipitated with ASF1A, and vice versa (Fig.  xref )."
29599486
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"In vivo deubiquitination assays showed an evident decrease in the polyubiquitination level of all ASF1A mutants except for K129R (Fig.  xref and Supplementary Fig.  xref ), while the association of USP52 with all ASF1A mutants was comparable to that of USP52 with wild-type ASF1A (Supplementary Fig.  xref )."
29599486
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"These results support the observation that ASF1A is physically associated with USP52 in vivo and suggest that ASF1A interacts with USP52 in cytoplasm."
29599486
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"Here we report that ASF1A is physically associated with USP52, which is previously identified as a pseudo-deubiquitinase."
29599486
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"Our findings suggest that inhibition of the enzymatic activity of USP52 or disruption of the association of USP52 with ASF1A, combined with chemo- or radio-therapy, could potentially improve the treatment of breast cancer."
29599486
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"To gain further support of the in vivo interaction between ASF1A and USP52, protein fractionation experiments with FLAG-ASF1A affinity eluates were carried out."
29599486
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"Collectively, these results indicate that ASF1A interacts with USP52 through the N-terminal region of ASF1A and the WD40 repeat domain of USP52."
29599486
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"Moreover, the reduction in ASF1A protein level associated with USP52 depletion was probably through a proteasome-mediated protein degradation mechanism, as the effect could be effectively blocked by a proteasome specific inhibitor, MG132 (Fig.  xref )."
29599486
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"Immunoprecipitation analysis revealed that USP52 is preferentially associated with ASF1A in the S phase of the cell cycle, when ASF1A transfers H3.1–H4 dimer to replicating chromatin."
29599486
PAN2 activates ASF1A.
| 15
PAN2 activates ASF1A. 10 / 15
| 15
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"USP52 promoted ASF1A stabilization facilitates chromatin assembly and favors cell cycle progression."
29599486
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"These results favor the argument that USP52 promoted ASF1A stabilization regulates DNA synthesis coupled chromatin assembly through ASF1A mediated deposition of H3K56Ac."
29599486
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"Taken together, these data indicate that USP52 targets ASF1A and K129 for deubiquitination and USP52 is a bona fide deubiquitinase for ASF1A."
29599486
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"In light of our observation that USP52 mediated ASF1A stabilization regulates the level of H3K56Ac, it is reasonable to postulate that USP52 and ASF1A signaling pathway plays a role in tumorigenesis."
29599486
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"These results are in favor of the role of USP52 promoted ASF1A stabilization in chromatin assembly thus cell cycle progression, and indicate that USP52 and ASF1A axis is required for breast cancer cell proliferation."
29599486
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"To corroborate the role of USP52 promoted ASF1A stabilization in chromatin replication, cellular extracts from cells used in MNase digestion assays were collected and analyzed by western blotting."
29599486
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"USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization."
29599486
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"Considering that ASF1A also plays an important role in replication independent chromatin assembly and chromatin disassembly during transcriptional activation XREF_BIBR, XREF_BIBR, XREF_BIBR, it is interesting to investigate whether USP52 promoted ASF1A stabilization plays a role in these processes."
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"Collectively, these results point a role of the USP52 promoted ASF1A stabilization in promoting breast carcinogenesis."
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"Collectively, these observations suggest that USP52 promoted ASF1A stabilization is potentially associated with breast carcinogenesis."
29599486
PAN2 deubiquitinates ASF1A.
1 | 4
PAN2 deubiquitinates ASF1A. 5 / 5
1 | 4
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"Interestingly, we demonstrate that USP52 is a bona fide ubiquitin specific protease, and USP52 promotes ASF1A deubiquitination and stabilization."
29599486
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"Since ASF1A is reported as a ubiquitinated protein 49, we then asked whether USP52 functions to deubiquitinate ASF1A."
29599486
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"Additionally, we find that USP52 is overexpressed in breast carcinomas, and its level of expression correlates with that of ASF1A."
29599486
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"USP52 deubiquitinates ASF1A."
29599486
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"Nevertheless, our study identified that USP52 is a bona fide USP, and revealed that USP52 deubiquitinates and stabilizes histone chaperone ASF1A."
29599486
PAN2 inhibits ASF1A.
| 1
PAN2 inhibits ASF1A. 1 / 1
| 1
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"Moreover, we reveal that impairment of USP52 promoted ASF1A stabilization results in growth arrest of breast cancer cells and sensitizes these cells to DNA damage."
29599486
PAN2 increases the amount of ASF1A.
| 1
Modified PAN2 increases the amount of ASF1A. 1 / 1
| 1
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"Next, we found overexpression of USP52 was able to restore the expression of ASF1A in USP52 deficient cells."
29599486
ASF1A affects PAN2
1 | 5 13
ASF1A binds PAN2.
1 | 2 13
PAN2 binds ASF1A. 10 / 16
1 | 2 13
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"Histone chaperone ASF1A is physically associated with USP52."
29599486
sparser
"To confirm the in vivo association of ASF1A with USP52, co-immunoprecipitation experiments were performed and the results showed that USP52 was efficiently co-immunoprecipitated with ASF1A, and vice versa (Fig.  xref )."
29599486
sparser
"In vivo deubiquitination assays showed an evident decrease in the polyubiquitination level of all ASF1A mutants except for K129R (Fig.  xref and Supplementary Fig.  xref ), while the association of USP52 with all ASF1A mutants was comparable to that of USP52 with wild-type ASF1A (Supplementary Fig.  xref )."
29599486
sparser
"These results support the observation that ASF1A is physically associated with USP52 in vivo and suggest that ASF1A interacts with USP52 in cytoplasm."
29599486
sparser
"Here we report that ASF1A is physically associated with USP52, which is previously identified as a pseudo-deubiquitinase."
29599486
sparser
"Our findings suggest that inhibition of the enzymatic activity of USP52 or disruption of the association of USP52 with ASF1A, combined with chemo- or radio-therapy, could potentially improve the treatment of breast cancer."
29599486
sparser
"To gain further support of the in vivo interaction between ASF1A and USP52, protein fractionation experiments with FLAG-ASF1A affinity eluates were carried out."
29599486
reach
"Collectively, these results indicate that ASF1A interacts with USP52 through the N-terminal region of ASF1A and the WD40 repeat domain of USP52."
29599486
sparser
"Moreover, the reduction in ASF1A protein level associated with USP52 depletion was probably through a proteasome-mediated protein degradation mechanism, as the effect could be effectively blocked by a proteasome specific inhibitor, MG132 (Fig.  xref )."
29599486
sparser
"Immunoprecipitation analysis revealed that USP52 is preferentially associated with ASF1A in the S phase of the cell cycle, when ASF1A transfers H3.1–H4 dimer to replicating chromatin."
29599486
ASF1A activates PAN2.
| 3
ASF1A activates PAN2. 3 / 3
| 3
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"Indeed, USP52 deficiency impaired chromatin assembly and DNA replication as well as S-phase progression, the effect of which could be largely restored by ASF1A gain of function."
29599486
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"Meanwhile, western blotting analysis revealed that the upregulation of H3K56Ac trigged by IR was disrupted upon USP52 depletion, the effect of which could be restored by ASF1A gain of function."
29599486
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"Taken together, these data indicate that USP52 targets ASF1A and K129 for deubiquitination and USP52 is a bona fide deubiquitinase for ASF1A."
29599486
PAN2 is modified
3 | 15
PAN2 is phosphorylated. 10 / 12
| 12
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"To further analyze the role of USP52 phosphorylation in regulating DNA end resection and HR, we re-expressed WT USP52 and USP52 S1003A mutant in USP52-deficient cells to compare their biological functions."
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"These results suggest that USP52 phosphorylation by ATM is important for its role in regulating DNA end resection and HR through regulating CtIP deubiquitination."
33097710
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"To further investigate the biological significance of USP52 phosphorylation, we compared the activities of WT USP52 and the S1003A mutant after DNA damage by in vitro deubiquitination assays."
33097710
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"Because the interaction between CtIP and USP52 was not changed before or after IR treatment, it is possible that the phosphorylation of USP52 increases its catalytic capability but not the affinity toward CtIP."
33097710
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"As shown in Supplementary Fig.  xref , xref , reconstitution of USP52-deficient cells with WT USP52 but not USP52 S1003A rescued USP52 depletion-induced defects, including CHK1 and RPA2 phosphorylation and IR and PARPi response, suggesting that USP52 phosphorylation by ATM is important for proper DDR."
33097710
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"Ccr4, Pan2, and Pan3 were phosphorylated in GlyLac medium, suggesting that the activities of Ccr4, Pan2, and Pan3 may be regulated by phosphorylation in response to change of carbon sources."
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"As shown in Fig.  xref , CtIP ubiquitination level was significantly decreased in cells expressing WT USP52 but not the S1003A mutant after IR treatment, suggesting that USP52 phosphorylation is critical for deubiquitinating CtIP following IR exposure."
33097710
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"We next examined which SQ/TQ site of USP52 was phosphorylated and found that the S1003A but not S469A mutation mostly abolished the phosphorylation of USP52 after DNA damage (Fig.  xref and Supplementary Fig.  xref ), suggesting that USP52 is phosphorylated on Ser-1003 in an ATM-dependent manner following IR treatment."
33097710
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"We hypothesized that ATM-mediated phosphorylation of USP52 activates its DUB activity."
33097710
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"As shown in Fig.  xref , incubating WT, but not the S1003A mutant of USP52, with ATM further decreased the ubiquitination level of CtIP, suggesting that ATM-mediated USP52 phosphorylation is important for USP52 activation to deubiquitinate CtIP following DNA damage."
33097710
PAN2 is phosphorylated on S1003. 3 / 3
| 3
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"These results suggest that phosphorylation of USP52 S1003 plays a vital role in regulating the DUB activity of USP52."
33097710
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"To further examine whether the phosphorylation of USP52 at S1003 regulates CtIP deubiquitination, we reconstituted WT or the S1003A mutants in USP52-deficient cells and examined the ubiquitination level of CtIP with or without IR treatment."
33097710
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"We next examined which SQ/TQ site of USP52 was phosphorylated and found that the S1003A but not S469A mutation mostly abolished the phosphorylation of USP52 after DNA damage (Fig.  xref and Supplementary Fig.  xref ), suggesting that USP52 is phosphorylated on Ser-1003 in an ATM-dependent manner following IR treatment."
33097710
PAN2 is phosphorylated on S1189. 2 / 2
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No evidence text available
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No evidence text available
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PAN2 is phosphorylated on S791. 1 / 1
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No evidence text available
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PAN2 affects HIF1A
| 1 9 1
PAN2 activates HIF1A.
| 1 6
PAN2 activates HIF1A. 7 / 7
| 1 6
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"To rule out any effects of USP52 on HIF1A translation, we performed polysome profiling on U2OS cells treated with either NT or USP52 siRNA."
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"Disrupting USP52 containing P-bodies by GW182 depletion reduces HIF1A mRNA."
23398456
eidos
"USP52 increases HIF-1alpha protein levels through stabilizing HIF-1alpha mRNA instead of affecting HIF-1alpha ubiquitination [ 69,84 ] ."
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"During a screening of mediators for HIF1A mediated hypoxic response, USP52 and PAN2, a component of P-bodies, was found to promote the stability of HIF1A mRNA in 3 ' UTR dependent manner, as documented with the use of knockdown experiments.156 However, the direct binding of this protein to AREs was not studied, and interactions with de facto RPBs, such as TTP, can possibly happen in P-bodies."
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"To investigate further the role of USP52in the HIF1A mediated hypoxic response, U2OS cells were treated with individual USP52 siRNA duplexes 1 and 3 and exposed to hypoxia."
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"This demonstrates that USP52 knockdown specifically reduces HIF1A mRNA abundance, and supports the previous observation that decreased HIF1A mRNA is associated with up-regulation of HIF2A [XREF_BIBR]."
23398456
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"To obtain insight into the observed USP52 mediated stabilization of HIF1A mRNA, we performed proteomic analysis of USP52 immunoprecipitates to identify new USP52 associated proteins."
23398456
PAN2 inhibits HIF1A.
| 2
PAN2 inhibits HIF1A. 2 / 3
| 2
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"Depletion of USP52 reduced HIF1A mRNA and protein levels and resulted in reduced expression of HIF1A regulated hypoxic targets due to a 3 '-UTR (untranslated region)-dependent poly (A)-tail-length-independent destabilization in HIF1A mRNA."
23398456
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"To address whether USP52 negatively regulates HIF1A protein through interactions with the VHL complex, U2OS cells were treated with MLN4924 [XREF_BIBR] to inhibit the NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8)-interacting enzyme and block VHL activity."
23398456
PAN2 increases the amount of HIF1A.
| 1
PAN2 increases the amount of HIF1A. 1 / 3
| 1
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"USP52 increases HIF-1alpha protein levels through stabilizing HIF-1alpha mRNA instead of affecting HIF-1alpha ubiquitination [XREF_BIBR, XREF_BIBR]."
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PAN2 binds HIF1A.
| 1
PAN2 binds HIF1A. 1 / 1
| 1
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"In order to determine whether the effect of USP52 depletion on HIF1A mRNA stability was associated with a change in HIF1A poly(A) tail length, we analysed poly(A) tail length in U2OS cells treated with NT or USP52 siRNA."
23398456
PABPC1 affects PAN2
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PABPC1 binds PAN2.
3 2 | 2 2
PAN2 binds PABPC1. 7 / 7
3 1 | 2 1
biogrid
No evidence text available
14583602
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No evidence text available
17785442
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No evidence text available
23398456
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"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."
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No evidence text available
14583602
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"Mangus et al. have shown that Pbp1 negatively regulates Pan2 deadenylase by disturbing the Pab1-Pan2 interaction, and that the cell extract from pbp1Δ single mutant in the stationary phase has stronger deadenylase activity than that in WT in vitro [ xref , xref ]."
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"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."
25084349
RNPC3 binds PAN2 and PABPC1. 1 / 1
| 1
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"At the oligomerization interface between the second and third Pab1, the RNP interacts with the WD40 domain of Pan2 at a conserved surface of the base of the β-propeller ( xref A and xref A)."
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PAN2 binds PAN3 and PABPC1. 1 / 1
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hprd
No evidence text available
18056425
PABPC1 activates PAN2.
| 2
PABPC1 activates PAN2. 2 / 2
| 2
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"Because Pab1 stimulates Pan2 and interacts directly with Pan3 through its C-terminal region, an alternative interpretation could be that removal of the corresponding Pab1 domain inhibits deadenylation by preventing Pan2 action."
17766253
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"Since Pab1 promotes Pan2 activity, one model is that this deadenylation reflects Pab1 bound to the first ~ 65 residues of the A tail, but the 3 ' most region is exposed and thereby rapidly deadenylated by Pan2."
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PABPC1 inhibits PAN2.
| 1
PABPC1 inhibits PAN2. 1 / 1
| 1
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"Because Pab1 stimulates Pan2 and interacts directly with Pan3 through its C-terminal region, an alternative interpretation could be that removal of the corresponding Pab1 domain inhibits deadenylation by preventing Pan2 action."
17766253
CNOT7 affects PAN2
| 3 9
CNOT7 binds PAN2.
| 2 9
CNOT7 binds PAN2, PAN3, and ccr4. 6 / 6
| 6
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"It appears that these two proteins do not directly interact with Pan2-Pan3 or the Ccr4-Caf1 deadenylase complex."
19838187
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
CNOT7 binds PAN2. 4 / 4
| 2 2
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"Therefore, Pan2-Pan3 and Ccr4-Caf1 complexes may communicate with each other in vivo via the interaction between Pan2 and Caf1."
18625844
sparser
"However, when HA-Pan2 was ectopically expressed alone ( xref ), endogenous Caf1, but not PABP, was coprecipitated with HA-Pan2, indicating a specific interaction between Pan2 and Caf1, either directly or indirectly."
18625844
sparser
"Therefore, Pan2–Pan3 and Ccr4–Caf1 complexes may communicate with each other in vivo via the interaction between Pan2 and Caf1."
18625844
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"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly (A) nucleases, respectively, their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
CNOT7 inhibits PAN2.
| 1
CNOT7 inhibits PAN2. 1 / 1
| 1
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"PAN2 depletion, like CAF1 depletion, did not cause an increase in steady-state levels of these mRNAs (XREF_FIG and E, and data not shown)."
19596809
Ccr4 affects PAN2
| 10
CNOT7 binds PAN2, PAN3, and ccr4. 6 / 6
| 6
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"It appears that these two proteins do not directly interact with Pan2-Pan3 or the Ccr4-Caf1 deadenylase complex."
19838187
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
PAN2 binds PAN3 and ccr4. 1 / 1
| 1
sparser
"Interestingly, interactions between Pan2-Pan3 and Ccr4-Not can be detected suggesting that both deadenylase complexes can reside in a higher order complex that may include other components ( xref )."
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BLNK binds PAN2, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
PAN2 binds PAN3, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN2 affects PABPC1
3 2 | 2 2
PAN2 binds PABPC1. 7 / 7
3 1 | 2 1
biogrid
No evidence text available
14583602
biogrid
No evidence text available
17785442
biogrid
No evidence text available
23398456
reach
"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."
25084349
hprd
No evidence text available
14583602
sparser
"Mangus et al. have shown that Pbp1 negatively regulates Pan2 deadenylase by disturbing the Pab1-Pan2 interaction, and that the cell extract from pbp1Δ single mutant in the stationary phase has stronger deadenylase activity than that in WT in vitro [ xref , xref ]."
28231297
reach
"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."
25084349
RNPC3 binds PAN2 and PABPC1. 1 / 1
| 1
sparser
"At the oligomerization interface between the second and third Pab1, the RNP interacts with the WD40 domain of Pan2 at a conserved surface of the base of the β-propeller ( xref A and xref A)."
31104843
PAN2 binds PAN3 and PABPC1. 1 / 1
1 |
hprd
No evidence text available
18056425
TFDP1 affects PAN2
8 |
TFDP1 decreases the amount of PAN2. 8 / 8
8 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Ccr4 affects CNOT7
| 7
CNOT7 binds PAN2, PAN3, and ccr4. 6 / 6
| 6
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"It appears that these two proteins do not directly interact with Pan2-Pan3 or the Ccr4-Caf1 deadenylase complex."
19838187
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN2 affects RBBP8
| 2 5
PAN2 binds RBBP8.
| 1 5
PAN2 binds RBBP8. 6 / 6
| 1 5
reach
"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
sparser
"As shown in Fig.  xref , the N-terminal region (AA17–AA160) of CtIP and the WD40 domain of USP52 are indispensable for the interaction between CtIP and USP52."
33097710
sparser
"Interestingly, the interaction between USP52 and CtIP did not change with IR treatment (Supplementary Fig.  xref ), suggesting their interactions are not DNA damage inducible."
33097710
sparser
"This further confirms the interaction between USP52 and CtIP in cells."
33097710
sparser
"As shown in Supplementary Fig.  xref and Fig.  xref , WT USP52, but not the USP52 ΔWD40 truncate, successfully rescued DSB resection and HR in USP52-depleted cells, suggesting that the USP52–CtIP interaction is important for the role of USP52 in DSB resection and HR."
33097710
sparser
"Because the interaction between CtIP and USP52 was not changed before or after IR treatment, it is possible that the phosphorylation of USP52 increases its catalytic capability but not the affinity toward CtIP."
33097710
PAN2 deubiquitinates RBBP8.
| 1
PAN2 deubiquitinates RBBP8. 1 / 1
| 1
reach
"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
E2F1 affects PAN2
7 |
E2F1 decreases the amount of PAN2. 7 / 7
7 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
CNOT7 affects ccr4
| 7
CNOT7 binds PAN2, PAN3, and ccr4. 6 / 6
| 6
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"It appears that these two proteins do not directly interact with Pan2-Pan3 or the Ccr4-Caf1 deadenylase complex."
19838187
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
RBBP8 affects PAN2
| 1 5
PAN2 binds RBBP8. 6 / 6
| 1 5
reach
"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
sparser
"As shown in Fig.  xref , the N-terminal region (AA17–AA160) of CtIP and the WD40 domain of USP52 are indispensable for the interaction between CtIP and USP52."
33097710
sparser
"Interestingly, the interaction between USP52 and CtIP did not change with IR treatment (Supplementary Fig.  xref ), suggesting their interactions are not DNA damage inducible."
33097710
sparser
"This further confirms the interaction between USP52 and CtIP in cells."
33097710
sparser
"As shown in Supplementary Fig.  xref and Fig.  xref , WT USP52, but not the USP52 ΔWD40 truncate, successfully rescued DSB resection and HR in USP52-depleted cells, suggesting that the USP52–CtIP interaction is important for the role of USP52 in DSB resection and HR."
33097710
sparser
"Because the interaction between CtIP and USP52 was not changed before or after IR treatment, it is possible that the phosphorylation of USP52 increases its catalytic capability but not the affinity toward CtIP."
33097710
CNOT7 affects PAN2, PAN3, and ccr4
| 6
CNOT7 binds PAN2, PAN3, and ccr4. 6 / 6
| 6
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"It appears that these two proteins do not directly interact with Pan2-Pan3 or the Ccr4-Caf1 deadenylase complex."
19838187
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
ATM affects PAN2
| 6
ATM phosphorylates PAN2. 4 / 4
| 4
sparser
"We further evaluated whether USP52 phosphorylation by ATM affects CHK1 and RPA2 phosphorylation and render cells resistant to cancer therapy."
33097710
sparser
"These results suggest that USP52 phosphorylation by ATM is important for its role in regulating DNA end resection and HR through regulating CtIP deubiquitination."
33097710
sparser
"Phosphorylation of USP52 by ATM under IR treatment."
33097710
sparser
"As shown in Supplementary Fig.  xref , xref , reconstitution of USP52-deficient cells with WT USP52 but not USP52 S1003A rescued USP52 depletion-induced defects, including CHK1 and RPA2 phosphorylation and IR and PARPi response, suggesting that USP52 phosphorylation by ATM is important for proper DDR."
33097710
ATM phosphorylates PAN2 on S1003. 2 / 2
| 2
sparser
"Our results suggest that the phosphorylation of USP52 on Ser-1003 by ATM increases the activity of USP52 to deubiquitinate CtIP and promote DNA end resection and HR repair."
33097710
sparser
"In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."
33097710
SFXN1 affects PAN2
| 5
SFXN1 binds PAN2. 5 / 5
| 5
sparser
"Therefore, we evaluated FPN expression by immunoblot (not detected in proteome) and demonstrated a decrease in expression in TCC-Pan2 and PANC-1 NCOA4 KD cells ( xref )."
35771492
sparser
"The xenografted PCa models have been studied using colon cancer (HCT-116, LS174T, HT29, SW480, SW620, LoVo, RKO, Caco-2, KM12, MDST8, HUTU80) [ xref , xref , xref , xref , xref ], pancreatic cancer (Panc-1, TCC-Pan2, BxPC3, AsPC-1) [ xref , xref , xref ], gastric cancer (60As6, HSC-44PE, HSC-58, MKN45-P) [ xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref ], and ovarian cancer (OVCAR3, OVCAR4, OVCAR5, OVCAR8, CAOV3, OVSAHO, OV2944-HM-1, SKOV-3) [ xref , xref , xref , xref ] cell lines."
33669017
sparser
"Intriguingly, LCN2 levels were also significantly elevated in TCC-Pan2 NCOA4 KD proteomes ( xref )."
35771492
sparser
"The xenografted PCa models have been studied using colon cancer (HCT-116, LS174T, HT29, SW480, SW620, LoVo, RKO, Caco-2, KM12, MDST8, HUTU80) [57] [58] [59] [60] [61] , pancreatic cancer (Panc-1, TCC-Pan2, BxPC3, AsPC-1) [62] [63] [64] , gastric cancer (60As6, HSC-44PE, HSC-58, MKN45-P) [56] [57] [58] [59] [60] [61] [62] [63] [64] [65] [66] [67] [68] [69] , and ovarian cancer (OVCAR3, OVCAR4, OVCAR5, OVCAR8, CAOV3, OVSAHO, OV2944-HM-1, SKOV-3) [59, [70] [71] [72] cell lines."
33669017
sparser
"To evaluate the potential for compensation of transferrin-mediated iron uptake to rescue proliferation, we tested TCC-Pan2 NCOA4 KD cells for rescue by holo-transferrin demonstrating a partial rescue ( xref )."
35771492
Pbp1 affects PAN2
| 4 1
Pbp1 inhibits PAN2.
| 3 1
Pbp1 inhibits PAN2. 4 / 4
| 3 1
sparser
"Further analysis should be needed to elucidate the physiological role of Pan2 inhibition by Pbp1 in the stationary phase."
28231297
reach
"Consistently, we found that the shortening of the LRG1 poly (A) tail length in the ccr4Delta pbp1Delta mutant required Pan2 deadenylase in vivo, and that Pbp1 inhibited Pan2 activity only in the stationary phase but not in the log phase."
28231297
reach
"Pbp1 negatively regulates Pan2 activity in the absence of Ccr4 in the stationary phase."
28231297
reach
"If Pan2 activity is inhibited by Pbp1, the LRG1 poly (A) tail length in the ccr4Delta pbp1Delta pan2Delta triple mutant would be longer than that in the ccr4Delta pbp1Delta double mutant in the stationary phase."
28231297
Pbp1 binds PAN2.
| 1
PAN2 binds Pbp1. 1 / 1
| 1
reach
"29 Furthermore, the poly (A)-nuclease subunit Pan2 binds to Pbp1, 27 and the poly (A)-polymerase binding proteins Fir1 and Ufd1 interact with Pbp1 and have also been implicated in processing the 3 '-e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15663938
PAN2 affects SFXN1
| 5
SFXN1 binds PAN2. 5 / 5
| 5
sparser
"Therefore, we evaluated FPN expression by immunoblot (not detected in proteome) and demonstrated a decrease in expression in TCC-Pan2 and PANC-1 NCOA4 KD cells ( xref )."
35771492
sparser
"The xenografted PCa models have been studied using colon cancer (HCT-116, LS174T, HT29, SW480, SW620, LoVo, RKO, Caco-2, KM12, MDST8, HUTU80) [ xref , xref , xref , xref , xref ], pancreatic cancer (Panc-1, TCC-Pan2, BxPC3, AsPC-1) [ xref , xref , xref ], gastric cancer (60As6, HSC-44PE, HSC-58, MKN45-P) [ xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref ], and ovarian cancer (OVCAR3, OVCAR4, OVCAR5, OVCAR8, CAOV3, OVSAHO, OV2944-HM-1, SKOV-3) [ xref , xref , xref , xref ] cell lines."
33669017
sparser
"Intriguingly, LCN2 levels were also significantly elevated in TCC-Pan2 NCOA4 KD proteomes ( xref )."
35771492
sparser
"The xenografted PCa models have been studied using colon cancer (HCT-116, LS174T, HT29, SW480, SW620, LoVo, RKO, Caco-2, KM12, MDST8, HUTU80) [57] [58] [59] [60] [61] , pancreatic cancer (Panc-1, TCC-Pan2, BxPC3, AsPC-1) [62] [63] [64] , gastric cancer (60As6, HSC-44PE, HSC-58, MKN45-P) [56] [57] [58] [59] [60] [61] [62] [63] [64] [65] [66] [67] [68] [69] , and ovarian cancer (OVCAR3, OVCAR4, OVCAR5, OVCAR8, CAOV3, OVSAHO, OV2944-HM-1, SKOV-3) [59, [70] [71] [72] cell lines."
33669017
sparser
"To evaluate the potential for compensation of transferrin-mediated iron uptake to rescue proliferation, we tested TCC-Pan2 NCOA4 KD cells for rescue by holo-transferrin demonstrating a partial rescue ( xref )."
35771492
PAN2 affects NLRP6
| 5
PAN2 binds NLRP6. 5 / 5
| 5
reach
"The miRNA- Argonaute family complex recruits the CCR4-NOT complex or the PAN2-PAN3 complex, leading to degradation of target mRNAs (64, 65)."
34349771
reach
"It is not only thought to facilitate interactions between the 5′ and 3′ ends of mRNP molecules (via its interaction with eIF4G; 20,21) but is also believed to modulate deadenylation via its interactions with the Pan2‐Pan3 complex 23."
31520451
reach
"As the heart of RISC, Argonaute2 (Ago2) recruits TNRC6, PABPC, and deadenylase complexes, i.e., the PAN2-PAN3 complex or CCR4-NOT complex to destabilize or repress mRNA [15–17]."
32746934
reach
"A recent cryoEM structure of the yeast Pan2-Pan3 complex provides an explanation for why it preferentially acts on the distal (not the proximal) poly(A) tail ."
34594027
reach
"Moreover, interactions between eIF4G and the poly[A]binding protein Pab1 are capable of mediating interactions between the 5′ and 3′ ends of mRNA 20, whereby Pab1 stimulates both translation initiation 21, 22 and deadenylation by the Pan2/Pan3 complex 23."
31520451
Valproic acid affects PAN2
4 |
Valproic acid decreases the amount of PAN2. 4 / 4
4 |
ctd
No evidence text available
29154799
ctd
No evidence text available
23179753
ctd
No evidence text available
27188386
ctd
No evidence text available
26272509
Bisphenol A affects PAN2
4 |
Bisphenol A decreases the amount of PAN2.
2 |
Bisphenol A decreases the amount of PAN2. 2 / 2
2 |
ctd
No evidence text available
30816183
ctd
No evidence text available
25181051
Bisphenol A methylates PAN2.
1 |
Bisphenol A methylates PAN2. 1 / 1
1 |
ctd
No evidence text available
30906313
Bisphenol A increases the amount of PAN2.
1 |
Bisphenol A increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
29165653
PAN2 affects chromatin assembly
| 4
PAN2 activates chromatin assembly. 4 / 4
| 4
reach
"USP52 promoted ASF1A stabilization facilitates chromatin assembly and favors cell cycle progression."
29599486
reach
"USP52 promotes chromatin assembly through stabilizing ASF1A."
29599486
reach
"These results suggest that USP52 promotes chromatin assembly in an ASF1A dependent manner."
29599486
reach
"We reveal that USP52 promotes chromatin assembly through stabilizing ASF1A, and point a role of USP52 in breast carcinogenesis and cellular resistance of breast cancer cells to DNA damage."
29599486
PABP affects PAN2
| 4
PABP activates PAN2.
| 3
PABP activates PAN2. 2 / 2
| 2
reach
"PABP regulates deadenylation of mRNPs by binding Pan3 and stimulating Pan2 nuclease activity and interacting with GW182 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR] through a C-terminal motif that is removed by both viral proteinases."
26610553
reach
"PAN2 is activated by PABP in vitro XREF_BIBR."
25968143
PABP bound to PAN3 activates PAN2. 1 / 1
| 1
reach
"For example, PABP 's interaction with Pan3 enhances Pan2 nuclease activity."
23224971
PABP binds PAN2.
| 1
PAN2 binds PABP. 1 / 1
| 1
reach
"The modest amount of endogenous PABP in the precipitate (XREF_FIG) suggests an indirect association between HA-Pan2 and PABP, presumably mediated via Pan3-V5, as HA-Pan2 alone did not pull down PABP (XREF_FIG)."
18625844
Guanosine affects PAN2
| 1 2
Guanosine inhibits PAN2. 2 / 2
| 1 1
sparser
"Caf1 shows strict specificity for poly(A) and is inhibited by all non-A nucleotides, whereas Pan2 is substantially inhibited only by guanosines at the end of a poly(A) tail ( xref )."
32295929
eidos
"Caf1 shows strict specificity for poly ( A ) and is inhibited by all non-A nucleotides , whereas Pan2 is substantially inhibited only by guanosines at the end of a poly ( A ) tail ( Fig. 3A , B ) ."
32295929
Guanosine inhibits PAN2. 1 / 1
| 1
sparser
"To understand why guanosines inhibit Pan2, we soaked AAGGA or AAGGAA RNAs into Pan2 UCH-Exo crystals, which diffracted to 3.3 Å resolution ( xref )."
31110294
PAN2 affects RNAPII
| 3
PAN2 activates RNAPII. 3 / 3
| 3
reach
"Finally, although knockdown of Ccr4 alone did not impact the reduction of RNAPII promoter occupancy in muSOX expressing cells, co-depletion of both Ccr4 and Pan2 restored RNAPII occupancy at the Gapdh promoter (XREF_FIG)."
26211836
reach
"Finally, although knockdown of Ccr4 alone did not impact the reduction of RNAPII promoter occupancy in muSOX-expressing cells, co-depletion of both Ccr4 and Pan2 restored RNAPII occupancy at the Gapdh promoter (Figure 2E)."
26211836
reach
"Finally, although knockdown of Ccr4 alone did notimpact the reduction of RNAPII promoter occupancy in muSOX expressing cells, co-depletion of both Ccr4 and Pan2 restored RNAPII occupancy at the Gapdh promoter (XREF_FIG E)."
26211836
PAN2 affects NFkappaB
| 3
PAN2 inhibits NFkappaB. 2 / 2
| 2
reach
"PAN2 also suppressed NF-kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in the TNF or IL-1 receptor signal transduction, including TRAF2, TRAF6, RIP, IRAK2, and NF-kappaB-inducing kinase as well as the IkappaB kinases IKKalpha and IKKbeta."
12093792
reach
"When expressed in HEK293 cells, PAN2 suppressed NF-kappaB induction by the cytokines tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta), suggesting that this protein operates at a point of convergence in these two cytokine signaling pathways."
12093792
PAN2 bound to CHUK inhibits NFkappaB. 1 / 1
| 1
reach
"On the other hand, PAN2 binds IKKalpha to reduce tumor necrosis factor (TNF)-alpha and IL-1beta-related NF-kappaB activation."
29904414
PAN2 affects MIA
| 3
PAN2 binds MIA. 3 / 3
| 3
sparser
"Increased expressions of PPARA1, ACAA1, FABP1, and FABP2 were detected in SNU-478 ampullary cancer cells compared to pancreatic cancer cells (Pan1 and MIA-Pan2) and gastric cancer cells (AGS) by qPCR (Supplementary Figure 2A-D)."
33390794
sparser
"Increased expressions of PPARA1, ACAA1, FABP1, and FABP2 were detected in SNU-478 ampullary cancer cells compared to pancreatic cancer cells (Pan1 and MIA-Pan2) and gastric cancer cells (AGS) by qPCR ( xref A-D)."
33390794
sparser
"Pancreatic cancer cell lines (Pan1 and MIA-Pan2), gastric cancer cell lines (AGS and MKN45), and a colon cancer cell line (HCT-116) were obtained from the Bioresource Collection and Research Center at the Food Industry Research and Development Institute (Hsinchu, Taiwan)."
33390794
PAN2 affects MARF1
1 | 1 1
PAN2 binds MARF1. 2 / 2
1 | 1
reach
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2-Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1."
30279526
biogrid
No evidence text available
27173435
PAN2 binds MARF1 and PAN3. 1 / 1
| 1
sparser
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
30279526
PAN2 affects LRG1
| 3
PAN2 decreases the amount of LRG1.
| 2
Modified PAN2 decreases the amount of LRG1. 2 / 2
| 2
reach
"However, the overexpression of PAN2 did not reduce Lrg1 level in the ccr4Delta background in the stationary phase (XREF_FIG)."
28231297
reach
"On the other hand, overexpression of PAN2 had little effect on LRG1 poly (A) tail length and did not reduce Lrg1 protein level in the ccr4Delta mutant."
28231297
PAN2 inhibits LRG1.
| 1
PAN2 inhibits LRG1. 1 / 1
| 1
reach
"PAN2 overexpression partially decreased LRG1 poly (A) tail length (XREF_FIG, lane 3)."
28231297
MIA affects PAN2
| 3
PAN2 binds MIA. 3 / 3
| 3
sparser
"Increased expressions of PPARA1, ACAA1, FABP1, and FABP2 were detected in SNU-478 ampullary cancer cells compared to pancreatic cancer cells (Pan1 and MIA-Pan2) and gastric cancer cells (AGS) by qPCR (Supplementary Figure 2A-D)."
33390794
sparser
"Increased expressions of PPARA1, ACAA1, FABP1, and FABP2 were detected in SNU-478 ampullary cancer cells compared to pancreatic cancer cells (Pan1 and MIA-Pan2) and gastric cancer cells (AGS) by qPCR ( xref A-D)."
33390794
sparser
"Pancreatic cancer cell lines (Pan1 and MIA-Pan2), gastric cancer cell lines (AGS and MKN45), and a colon cancer cell line (HCT-116) were obtained from the Bioresource Collection and Research Center at the Food Industry Research and Development Institute (Hsinchu, Taiwan)."
33390794
MARF1 affects PAN2
1 | 1 1
PAN2 binds MARF1. 2 / 2
1 | 1
reach
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2-Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1."
30279526
biogrid
No evidence text available
27173435
PAN2 binds MARF1 and PAN3. 1 / 1
| 1
sparser
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
30279526
FUS affects PAN2
| 3
FUS inhibits PAN2.
| 2
FUS inhibits PAN2. 2 / 2
| 2
reach
"These data suggest that FUS sequesters PAN2 on PABPC1 and prevents it from deadenylating the poly (A) tail of the bound mRNA (XREF_SUPPLEMENTARY)."
25968143
reach
"These data suggest that FUS might sequester PAN2 on the PABP from attacking the poly (A) tail."
25968143
FUS binds PAN2.
| 1
PAN2 binds FUS. 1 / 1
| 1
reach
"Moreover, CPSF6 and PAN2 interacted with FUS both in the presence and absence of RNase A, indicating that they form an RNA independent protein complex (XREF_FIG)."
25968143
Structure affects PAN2
| 2
Structure activates PAN2. 2 / 2
| 2
eidos
"Together , our data show that the intrinsic single-stranded helix of poly ( A ) is exploited by Pan2 for specificity and recognition , and that disruption of this structure is sufficient to inhibit Pan2 ( Fig. 6A ) ."
32295929
eidos
"Our biochemical , biophysical , and structural investigations suggest that poly ( A ) forms an intrinsic base-stacked , single-stranded helical conformation that is recognized by Pan2 , and that disruption of this structure inhibits both Pan2 and Caf1 ."
32295929
Pirinixic acid affects PAN2
2 |
Pirinixic acid increases the amount of PAN2.
1 |
Pirinixic acid increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid activates PAN2.
1 |
Pirinixic acid activates PAN2. 1 / 1
1 |
ctd
No evidence text available
19710929
Phenylmercury acetate decreases the amount of PAN2. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Exonuclease affects ccr4
| 2
BLNK binds PAN2, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
PAN2 binds PAN3, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
ZFP36 affects PAN2
2 |
ZFP36 binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
21078877
biogrid
No evidence text available
21078877
ZEB1 affects PAN2
2 |
ZEB1 binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
29119051
biogrid
No evidence text available
29119051
TNRC6C affects PAN2
2 |
PAN2 binds TNRC6C. 2 / 2
2 |
biogrid
No evidence text available
21984184
biogrid
No evidence text available
21981923
TFDP2 affects PAN2
2 |
TFDP2 decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
STAT5B affects PAN2
2 |
STAT5B decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
RNPC3 affects PAN2
| 2
RNPC3 binds PAN2 and PABPC1. 1 / 1
| 1
sparser
"At the oligomerization interface between the second and third Pab1, the RNP interacts with the WD40 domain of Pan2 at a conserved surface of the base of the β-propeller ( xref A and xref A)."
31104843
RNPC3 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
RELA affects PAN2
2 |
RELA decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
RB1 affects PAN2
2 |
RB1 decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
PLEC affects PAN2
2 |
PAN2 binds PLEC. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23398456
PAN2
| 2
PAN2 translocates. 1 / 1
| 1
reach
"It is therefore possible that GW182 recruits USP52 to P-bodies through interactions with PAN3 [XREF_BIBR]."
23398456
PAN2 translocates to the contact site. 1 / 1
| 1
reach
"We find no evidence that PAN2 recruits PAN1 to the GMC contact site via a direct or indirect physical interaction, but PAN2 interacts with itself."
23175742
PAN2 affects translation
| 2
PAN2 inhibits translation.
| 1
PAN2 bound to PAN3 inhibits translation. 1 / 1
| 1
reach
"In contrast, tethered PAN3 did not repress reporter expression (XREF_SUPPLEMENTARY), suggesting that the PAN2 and PAN3 complex can not repress translation in the absence of deadenylation."
23463101
PAN2 activates translation.
| 1
PAN2 activates translation. 1 / 1
| 1
reach
"To rule out any effects of USP52 on HIF1A translation, we performed polysome profiling on U2OS cells treated with either NT or USP52 siRNA."
23398456
PAN2 affects exonuclease
| 2
BLNK binds PAN2, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
PAN2 binds PAN3, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN2 inhibits cell population proliferation. 2 / 2
| 2
reach
"USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer."
34533198
reach
"This study demonstrates that USP52 inhibits cancer cell proliferation through downregulation of cyclin D1 as well as AKT/mTOR signaling pathway inhibition."
34533198
PAN2 affects ZFP36
2 |
ZFP36 binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
21078877
biogrid
No evidence text available
21078877
PAN2 affects ZEB1
2 |
ZEB1 binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
29119051
biogrid
No evidence text available
29119051
PAN2 affects TNRC6C
2 |
PAN2 binds TNRC6C. 2 / 2
2 |
biogrid
No evidence text available
21984184
biogrid
No evidence text available
21981923
PAN2 affects RNPC3
| 2
RNPC3 binds PAN2 and PABPC1. 1 / 1
| 1
sparser
"At the oligomerization interface between the second and third Pab1, the RNP interacts with the WD40 domain of Pan2 at a conserved surface of the base of the β-propeller ( xref A and xref A)."
31104843
RNPC3 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
PAN2 affects RNAPII promoter
| 2
PAN2 inhibits RNAPII promoter. 2 / 2
| 2
reach
"Conversely, our observation that knockdown of the Ccr4 and Pan2 deadenylases increased RNAPII promoter occupancy in uninfected cells suggests that decreased cytoplasmic decay stimulates transcription in mammalian cells."
26211836
reach
"Finally, although knockdown of Ccr4 alone did not impact the reduction of RNAPII promoter occupancy in muSOX-expressing cells, co-depletion of both Ccr4 and Pan2 restored RNAPII occupancy at the Gapdh promoter (Figure 2E)."
26211836
PAN2 affects PLEC
2 |
PAN2 binds PLEC. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23398456
PAN2 affects FLU
| 2
PAN2 binds FLU. 2 / 2
| 2
sparser
"We could not verify whether the one gene (Flu-pan2) detected by FilmArray RP in two “equivocal” samples were true positive."
29895452
sparser
"We could not verify whether the one gene (Flu-pan2) detected by FilmArray RP in two "equivocal" samples were true positive."
29895452
PAN2 affects CCT7
2 |
CCT7 binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
23398456
biogrid
No evidence text available
19615732
PAN2 affects AGO2
| 2
PAN2 binds AGO2. 2 / 2
| 2
reach
"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."
25084349
reach
"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."
25084349
HNF4A affects PAN2
2 |
HNF4A decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
HMGA1 affects PAN2
1 1 |
HMGA1 decreases the amount of PAN2.
1 |
HMGA1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
HMGA1 binds PAN2.
1 |
PAN2 binds HMGA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
FLU affects PAN2
| 2
PAN2 binds FLU. 2 / 2
| 2
sparser
"We could not verify whether the one gene (Flu-pan2) detected by FilmArray RP in two “equivocal” samples were true positive."
29895452
sparser
"We could not verify whether the one gene (Flu-pan2) detected by FilmArray RP in two "equivocal" samples were true positive."
29895452
E2F4 affects PAN2
2 |
E2F4 decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
CNOT7 affects ETF1, PAN2, PAN3, ccr4, and eRF3
| 2
CNOT7 binds PAN2, PAN3, ETF1, ccr4, and eRF3. 2 / 2
| 2
sparser
"Interestingly, translation termination complexes eRF1-eRF3, Pan2-Pan3, and Caf1-Ccr4 competitively interact with polyadenylate-binding protein PABPC1."
18056425
sparser
"Recent studies showed that translation termination complexes eRF1–eRF3, Pan2–Pan3, and Caf1–Ccr4 competitively bind to PABPC1via the PAM2 motifs of eRF3, Pan3, and Tob."
20096703
CCT7 affects PAN2
2 |
CCT7 binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
23398456
biogrid
No evidence text available
19615732
BZU2 affects PAN2
| 2
BZU2 activates PAN2. 2 / 2
| 2
reach
"We speculate that BZU2/ZmMUTE combines with additional unknown factors to activate P3 of the PAN2 promoter in vivo (Fig 7, S7 Fig and S8 Fig), by analogy to the observation that the DNA binding specificity of AtMUTE depends on its dimerization partner ICE1 or SCRM2 [37]."
31465456
reach
"Unexpectedly, yeast one-hybrid and EMSA data show that BZU2/ZmMUTE is not able to activate P3 of the promoter of PAN2 in vitro, but the ChIP-qPCR data indicate that BZU2/ZmMUTE can activate P3 of the PAN2 promoter in vivo."
31465456
AGO2 affects PAN2
| 2
PAN2 binds AGO2. 2 / 2
| 2
reach
"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."
25084349
reach
"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."
25084349
Zinc atom affects PAN2
1 |
Zinc atom increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
18593933
Uracil affects PAN2
| 1
Uracil inhibits PAN2. 1 / 1
| 1
eidos
"The Stacked , Helical Structure of Poly ( A ) is Important in Deadenylation In vitro deadenylation assays showed that Pan2 was not strongly inhibited by uracils ( Us ) or cytosines ( Cs ) at the end of a poly ( A ) tail ( Fig. 3A , B ) , but these nucleotides did not show the characteristic CD signature of helical poly ( A ) , either alone ( Fig. 3E ) or in the context of oligo ( A ) ( Fig. 4A ) ."
32295929
Troglitazone affects PAN2
1 |
Troglitazone decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
28973697
Topotecan affects PAN2
1 |
Topotecan decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25729387
Thapsigargin affects PAN2
1 |
Thapsigargin increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
22378314
Response to hypoxia affects PAN2
1 |
Response to hypoxia increases the amount of PAN2. 1 / 1
1 |
bel
"from table 1 and table 2 in the full text:"
14645546
Quercetin affects PAN2
1 |
Quercetin increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
21632981
Phorbol 13-acetate 12-myristate decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25613284
Paracetamol affects PAN2
1 |
Paracetamol decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
21420995
Pan affects PAN2
| 1
PAN2 binds pan. 1 / 1
| 1
reach
"HuR may modulate translation of several ARE-mRNAs by a process that is independent of ARE or 3 ' UTR, which involves binding of HuR to IRES in the 5 ' UTR.19, 20, 21 AREs mediate their effects on mRNA decay by first enhancing deadenylation (polyA shortening), a first step in mRNA decay facilitated by CCR4 and NOT and PAN2 and PAN complexes."
27251431
Oxaliplatin affects PAN2
1 |
Oxaliplatin decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25729387
Nuclease affects ccr4
| 1
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
Methylmercury chloride decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
28001369
Methyl methanesulfonate increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23649840
Jinfukang affects PAN2
1 |
Jinfukang increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
27392435
Hsa-miR-875-5p affects PAN2
1 |
Hsa-miR-875-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-8055 affects PAN2
1 |
Hsa-miR-8055 decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-770-5p affects PAN2
1 |
Hsa-miR-770-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24374217
Hsa-miR-6864-3p affects PAN2
1 |
Hsa-miR-6864-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6826-3p affects PAN2
1 |
Hsa-miR-6826-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6782-3p affects PAN2
1 |
Hsa-miR-6782-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6756-3p affects PAN2
1 |
Hsa-miR-6756-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6726-3p affects PAN2
1 |
Hsa-miR-6726-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6131 affects PAN2
1 |
Hsa-miR-6131 decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5587-5p affects PAN2
1 |
Hsa-miR-5587-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-484 affects PAN2
1 |
Hsa-miR-484 decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4764-3p affects PAN2
1 |
Hsa-miR-4764-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-454-5p affects PAN2
1 |
Hsa-miR-454-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4446-5p affects PAN2
1 |
Hsa-miR-4446-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4294 affects PAN2
1 |
Hsa-miR-4294 decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-377-5p affects PAN2
1 |
Hsa-miR-377-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24374217
Hsa-miR-3672 affects PAN2
1 |
Hsa-miR-3672 decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3663-5p affects PAN2
1 |
Hsa-miR-3663-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3155b affects PAN2
1 |
Hsa-miR-3155b decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3155a affects PAN2
1 |
Hsa-miR-3155a decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3144-3p affects PAN2
1 |
Hsa-miR-3144-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3127-3p affects PAN2
1 |
Hsa-miR-3127-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-302b-5p affects PAN2
1 |
Hsa-miR-302b-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-29a-3p affects PAN2
1 |
Hsa-miR-29a-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-222-3p affects PAN2
1 |
Hsa-miR-222-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-1249-3p affects PAN2
1 |
Hsa-miR-1249-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hexabromocyclododecane decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
29177809
HCG_1757335 affects PAN2
1 |
PAN2 binds hCG_1757335. 1 / 1
1 |
biogrid
No evidence text available
23398456
Furan affects PAN2
1 |
Furan demethylates PAN2. 1 / 1
1 |
ctd
No evidence text available
22079235
Formaldehyde affects PAN2
1 |
Formaldehyde increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23649840
Flutamide affects PAN2
1 |
Flutamide increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
24793618
Exonuclease affects PAN3
| 1
PAN2 binds PAN3, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
Exonuclease affects BLNK
| 1
BLNK binds PAN2, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
Endosulfan affects PAN2
1 |
Endosulfan decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
29391264
Dorsomorphin affects PAN2
1 |
Dorsomorphin decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
27188386
Diarsenic trioxide affects PAN2
1 |
Diarsenic trioxide decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
27829220
Cytosine affects PAN2
| 1
Cytosine inhibits PAN2. 1 / 1
| 1
eidos
"The Stacked , Helical Structure of Poly ( A ) is Important in Deadenylation In vitro deadenylation assays showed that Pan2 was not strongly inhibited by uracils ( Us ) or cytosines ( Cs ) at the end of a poly ( A ) tail ( Fig. 3A , B ) , but these nucleotides did not show the characteristic CD signature of helical poly ( A ) , either alone ( Fig. 3E ) or in the context of oligo ( A ) ( Fig. 4A ) ."
32295929
Cytoplasmic poly A binding protein PABPC1 is cofactor affects PAN2
| 1
Cytoplasmic poly A binding protein PABPC1 is cofactor activates PAN2. 1 / 1
| 1
eidos
"Poliovirus proteases also target and degrade a variety of cellular proteins , including the cytoplasmic poly ( A ) binding protein PABPC1 [ 47 ] , which is a cofactor that stimulates the Pan2 / 3 deadenylase ."
21640425
Cyclosporin A affects PAN2
1 |
Cyclosporin A increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
27989131
Coumestrol affects PAN2
1 |
Coumestrol increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
19167446
Copper(II) sulfate affects PAN2
1 |
Copper(II) sulfate decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
19549813
Cobalt dichloride affects PAN2
1 |
Cobalt dichloride decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
19376846
Ccr4 affects nuclease
| 1
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
Ccr4 affects BLNK
| 1
BLNK binds PAN2, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
Carbon nanotube affects PAN2
1 |
Carbon nanotube decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25554681
Butanal affects PAN2
1 |
Butanal decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
26079696
Bis(2-ethylhexyl) phthalate decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
31163220
Benzo[a]pyrene affects PAN2
1 |
Benzo[a]pyrene increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
22228805
Base-stacking affects PAN2
| 1
Base-stacking activates PAN2. 1 / 1
| 1
eidos
"This supports the finding that disruption of base-stacking inhibits Pan2 , and that Pan2 requires its substrate to adopt a poly ( A ) - like stacked , helical conformation ."
32295929
Aflatoxin B1 affects PAN2
1 |
Aflatoxin B1 methylates PAN2. 1 / 1
1 |
ctd
No evidence text available
27153756
Abrine affects PAN2
1 |
Abrine increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
31054353
ZmMUTE affects PAN2
| 1
ZmMUTE activates PAN2. 1 / 1
| 1
reach
"Unexpectedly, yeast one-hybrid and EMSA data show that BZU2/ZmMUTE is not able to activate P3 of the promoter of PAN2 in vitro, but the ChIP-qPCR data indicate that BZU2/ZmMUTE can activate P3 of the PAN2 promoter in vivo."
31465456
ZmMUTE combines affects PAN2
| 1
ZmMUTE combines activates PAN2. 1 / 1
| 1
reach
"We speculate that BZU2/ZmMUTE combines with additional unknown factors to activate P3 of the PAN2 promoter in vivo (Fig 7, S7 Fig and S8 Fig), by analogy to the observation that the DNA binding specificity of AtMUTE depends on its dimerization partner ICE1 or SCRM2 [37]."
31465456
ZNF234 affects PAN2
1 |
ZNF234 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
YWHAE affects PAN2
1 |
YWHAE binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
YUH1 affects PAN2
| 1
PAN2 binds YUH1 and EXO. 1 / 1
| 1
sparser
"The lack of base-specific interactions between Pan2 UCH-Exo and adenines was surprising given that Pan2 displayed strong specificity against guanosines ( xref )."
31110294
YES1 affects PAN2
1 |
YES1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
YBX3 affects PAN2
1 |
PAN2 binds YBX3. 1 / 1
1 |
biogrid
No evidence text available
23398456
YBX1 affects PAN2
1 |
PAN2 binds YBX1. 1 / 1
1 |
biogrid
No evidence text available
23398456
XRN2 affects PAN2
1 |
XRN2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
VIM affects PAN2
1 |
VIM binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
VDR affects PAN2
1 |
VDR decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
UBTD1 affects PAN2
1 |
PAN2 binds UBTD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
UACA affects PAN2
1 |
UACA binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TXN affects PAN2
1 |
TXN binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUFM affects PAN2
1 |
TUFM binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUBB4B affects PAN2
1 |
PAN2 binds TUBB4B. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUBB affects PAN2
1 |
PAN2 binds TUBB. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUBA1B affects PAN2
1 |
TUBA1B binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUBA1A affects PAN2
1 |
PAN2 binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
TRIM35 affects PAN2
1 |
TRIM35 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM21 affects PAN2
1 |
TRIM21 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TPM4 affects PAN2
1 |
TPM4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TPM3P4 affects PAN2
1 |
PAN2 binds TPM3P4. 1 / 1
1 |
biogrid
No evidence text available
23398456
TPM3 affects PAN2
1 |
TPM3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TPM1 affects PAN2
1 |
TPM1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TP53 affects PAN2
1 |
TP53 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TOB2 affects PAN2
1 |
TOB2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
17785442
TNRC6A affects PAN2
1 |
TNRC6A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
21984185
TMOD3 affects PAN2
1 |
TMOD3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TMOD2 affects PAN2
1 |
TMOD2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TMOD1 affects PAN2
1 |
TMOD1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TLX2 affects PAN2
1 |
TLX2 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
TJP1 affects PAN2
1 |
TJP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
THRAP3 affects PAN2
1 |
PAN2 binds THRAP3. 1 / 1
1 |
biogrid
No evidence text available
23398456
TFAM affects PAN2
1 |
TFAM binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TET2 affects PAN2
1 |
PAN2 binds TET2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TCP1 affects PAN2
1 |
TCP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TCOF1 affects PAN2
1 |
TCOF1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SVIL affects PAN2
1 |
SVIL binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
STMN1 affects PAN2
1 |
PAN2 binds STMN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
STK38L affects PAN2
1 |
STK38L binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
STING1 affects PAN2
1 |
PAN2 binds STING1. 1 / 1
1 |
biogrid
No evidence text available
27801882
STAT5A affects PAN2
1 |
STAT5A decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
SSBP1 affects PAN2
1 |
SSBP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRSF8 affects PAN2
1 |
SRSF8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRSF7 affects PAN2
1 |
SRSF7 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRSF6 affects PAN2
1 |
SRSF6 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRSF3 affects PAN2
1 |
SRSF3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRRM2 affects PAN2
1 |
SRRM2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRP14 affects PAN2
1 |
SRP14 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SQSTM1 affects PAN2
1 |
SQSTM1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SPTBN1 affects PAN2
1 |
SPTBN1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SPTAN1 affects PAN2
1 |
SPTAN1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SPECC1L affects PAN2
1 |
PAN2 binds SPECC1L. 1 / 1
1 |
biogrid
No evidence text available
23398456
SP1 affects PAN2
1 |
SP1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
SOWAHA affects PAN2
1 |
PAN2 binds SOWAHA. 1 / 1
1 |
biogrid
No evidence text available
27173435
SNRPD2 affects PAN2
1 |
SNRPD2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SNRPD1 affects PAN2
1 |
SNRPD1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SNRPB affects PAN2
1 |
SNRPB binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SNRNP70 affects PAN2
1 |
SNRNP70 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SMPDL3B affects PAN2
1 |
PAN2 binds SMPDL3B. 1 / 1
1 |
biogrid
No evidence text available
23398456
SMN1 affects PAN2
1 |
SMN1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SH3BGRL2 affects PAN2
1 |
SH3BGRL2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SFPQ affects PAN2
1 |
SFPQ binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SF3B6 affects PAN2
1 |
PAN2 binds SF3B6. 1 / 1
1 |
biogrid
No evidence text available
23398456
SF3A2 affects PAN2
1 |
SF3A2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SERBP1 affects PAN2
1 |
SERBP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SEC16A affects PAN2
1 |
PAN2 binds SEC16A. 1 / 1
1 |
biogrid
No evidence text available
23398456
SART1 affects PAN2
1 |
SART1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RUVBL2 affects PAN2
1 |
RUVBL2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RRP1 affects PAN2
1 |
RRP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RRAS2 affects PAN2
1 |
RRAS2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS9 affects PAN2
1 |
RPS9 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS8 affects PAN2
1 |
RPS8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS7 affects PAN2
1 |
RPS7 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS4X affects PAN2
1 |
RPS4X binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS3A affects PAN2
1 |
RPS3A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS3 affects PAN2
1 |
RPS3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS26 affects PAN2
1 |
RPS26 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS25 affects PAN2
1 |
RPS25 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS24 affects PAN2
1 |
RPS24 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS23 affects PAN2
1 |
RPS23 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS2 affects PAN2
1 |
RPS2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS19 affects PAN2
1 |
RPS19 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS18 affects PAN2
1 |
RPS18 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS17 affects PAN2
1 |
RPS17 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS15A affects PAN2
1 |
RPS15A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS14 affects PAN2
1 |
RPS14 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS12 affects PAN2
1 |
RPS12 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS11 affects PAN2
1 |
RPS11 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPLP0 affects PAN2
1 |
RPLP0 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL7A affects PAN2
1 |
RPL7A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL7 affects PAN2
1 |
RPL7 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL6 affects PAN2
1 |
RPL6 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL5 affects PAN2
1 |
RPL5 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL4 affects PAN2
1 |
RPL4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL38 affects PAN2
1 |
RPL38 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL37 affects PAN2
1 |
RPL37 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL36A affects PAN2
1 |
RPL36A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL36 affects PAN2
1 |
RPL36 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL35A affects PAN2
1 |
RPL35A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL35 affects PAN2
1 |
RPL35 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL34 affects PAN2
1 |
RPL34 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL32 affects PAN2
1 |
RPL32 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL31 affects PAN2
1 |
RPL31 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL30 affects PAN2
1 |
RPL30 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL3 affects PAN2
1 |
RPL3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL29 affects PAN2
1 |
RPL29 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL28 affects PAN2
1 |
RPL28 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL27A affects PAN2
1 |
RPL27A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL27 affects PAN2
1 |
RPL27 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL26L1 affects PAN2
1 |
RPL26L1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL26 affects PAN2
1 |
RPL26 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL24 affects PAN2
1 |
RPL24 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL23A affects PAN2
1 |
RPL23A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL23 affects PAN2
1 |
RPL23 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL21 affects PAN2
1 |
RPL21 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL19 affects PAN2
1 |
RPL19 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL18A affects PAN2
1 |
RPL18A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL18 affects PAN2
1 |
RPL18 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL17 affects PAN2
1 |
RPL17 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL15 affects PAN2
1 |
RPL15 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL13A affects PAN2
1 |
RPL13A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL13 affects PAN2
1 |
RPL13 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL12 affects PAN2
1 |
RPL12 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL10A affects PAN2
1 |
RPL10A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL10 affects PAN2
1 |
RPL10 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPA2 affects PAN2
1 |
RPA2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPA1 affects PAN2
1 |
RPA1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RNPC3 affects PAN3
| 1
RNPC3 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
RNPC3 affects PABPC1
| 1
RNPC3 binds PAN2 and PABPC1. 1 / 1
| 1
sparser
"At the oligomerization interface between the second and third Pab1, the RNP interacts with the WD40 domain of Pan2 at a conserved surface of the base of the β-propeller ( xref A and xref A)."
31104843
RNF2 affects PAN2
1 |
RNF2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
RNF144B affects PAN2
1 |
PAN2 binds RNF144B. 1 / 1
1 |
biogrid
No evidence text available
23105109
RIOK1 affects PAN2
1 |
RIOK1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RCN2 affects PAN2
1 |
PAN2 binds RCN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RBM10 affects PAN2
1 |
PAN2 binds RBM10. 1 / 1
1 |
biogrid
No evidence text available
23398456
RBCK1 affects PAN2
1 |
RBCK1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23105109
RBBP4 affects PAN2
1 |
PAN2 binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
23398456
RAI14 affects PAN2
1 |
RAI14 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
Plant Extracts affects PAN2
1 |
Plant Extracts increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23557933
Particulate Matter affects PAN2
1 |
Particulate Matter increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
17295261
Pan3S affects PAN2
| 1
Pan3S activates PAN2. 1 / 1
| 1
reach
"Pan2 deadenylase activity is enhanced by Pan3S but suppressed by Pan3L."
28559491
Pan3L affects PAN2
| 1
Pan3L inhibits PAN2. 1 / 1
| 1
reach
"Pan2 deadenylase activity is enhanced by Pan3S but suppressed by Pan3L."
28559491
Pab1p affects PAN2
| 1
Pab1p activates PAN2. 1 / 1
| 1
reach
"While Pab1p stimulates PAN2, the association of poly (A) binding proteins with human or Xenopus mRNAs appears to protect the transcript from deadenylation (Bernstein et al. 1989; Brown et al. 1996; Wo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10882133
PUF3C affects PAN2
| 1
PAN2 binds PUF3C. 1 / 1
| 1
reach
"We also assessed whether PUF3C could interact with PAN2."
20435044
PSMC5 affects PAN2
1 |
PAN2 binds PSMC5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PRNP affects PAN2
1 |
PAN2 binds PRNP. 1 / 1
1 |
biogrid
No evidence text available
23398456
PRMT5 affects PAN2
1 |
PRMT5 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PPP1R12B affects PAN2
1 |
PAN2 binds PPP1R12B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PPP1R12A affects PAN2
1 |
PAN2 binds PPP1R12A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PPM1B affects PAN2
1 |
PAN2 binds PPM1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PPARA affects PAN2
1 |
PPARA decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
POU3F1 affects PAN2
1 |
POU3F1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
POM121C affects PAN2
1 |
PAN2 binds POM121C. 1 / 1
1 |
biogrid
No evidence text available
27173435
POM121 affects PAN2
1 |
POM121 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PKM affects PAN2
1 |
PAN2 binds PKM. 1 / 1
1 |
biogrid
No evidence text available
23398456
PKC affects PAN3
| 1
PKC binds PAN2 and PAN3. 1 / 1
| 1
sparser
"When we tested the interaction of the ct Pan2–Pan3 PKC complex with polyA RNA, the binding was comparable to ct Pan3 PKC alone (Fig  xref B)."
24872509
PITX2 affects PAN2
1 |
PITX2 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
PFDN2 affects PAN2
1 |
PAN2 binds PFDN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PCM1 affects PAN2
1 |
PAN2 binds PCM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PCI 5002 affects PAN2
1 |
PCI 5002 increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
18593933
PCGF5 affects PAN2
1 |
PAN2 binds PCGF5. 1 / 1
1 |
biogrid
No evidence text available
27173435
PCGF3 affects PAN2
1 |
PCGF3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PCBP1 affects PAN2
1 |
PAN2 binds PCBP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAWR affects PAN2
1 |
PAN2 binds PAWR. 1 / 1
1 |
biogrid
No evidence text available
23398456
PARP1 affects PAN2
1 |
PAN2 binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN3 affects nuclease
| 1
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN3 affects exonuclease
| 1
PAN2 binds PAN3, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN3 affects RNPC3
| 1
RNPC3 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
PAN3 affects PKC
| 1
PKC binds PAN2 and PAN3. 1 / 1
| 1
sparser
"When we tested the interaction of the ct Pan2–Pan3 PKC complex with polyA RNA, the binding was comparable to ct Pan3 PKC alone (Fig  xref B)."
24872509
PAN3 affects PABPC1
1 |
PAN2 binds PAN3 and PABPC1. 1 / 1
1 |
hprd
No evidence text available
18056425
PAN3 affects MTA2
| 1
PAN2 binds PAN3 and MTA2. 1 / 1
| 1
sparser
"In summary, we found that it was difficult to disrupt the Pan2–Pan3 interaction by deletion of substantial regions of ct Pan2 PID and show that a core region (residues 343–406) makes a major contribution to the association of ct Pan2 and ct Pan3."
24872509
PAN3 affects MARF1
| 1
PAN2 binds MARF1 and PAN3. 1 / 1
| 1
sparser
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
30279526
PAN2 affects transport
| 1
PAN2 inhibits transport. 1 / 1
| 1
reach
"An alternative view is that since a pan2 defect can block mRNA transport out of the nucleus in 50% of the cells observed, the combination of a ccr4 deletion and this transport defect is the cause for the lack of COX17 mRNA deadenylation in the ccr4 pan2 strain background."
20435044
PAN2 activates signal transduction. 1 / 1
| 1
reach
"This study demonstrates that USP52 inhibits cancer cell proliferation through downregulation of cyclin D1 as well as AKT/mTOR signaling pathway inhibition."
34533198
PAN2 affects response to hypoxia
| 1
PAN2 activates response to hypoxia. 1 / 1
| 1
reach
"Interestingly, it has been reported previously that USP52 and KIAA0710 mRNA itself was induced 3.1-fold in response to hypoxia determined by microarray analysis of human renal cancer 786-O cells [XREF_BIBR]."
23398456
reach
"USP52 knockdown specifically impaired the hypoxia response, as it caused no such impairment to the NF-kappaB (nuclear factor kappaB) response after TNFalpha (tumour necrosis factor alpha) stimulation of the HeLa C57A cell line [XREF_BIBR]."
23398456
PAN2 affects pan
| 1
PAN2 binds pan. 1 / 1
| 1
reach
"HuR may modulate translation of several ARE-mRNAs by a process that is independent of ARE or 3 ' UTR, which involves binding of HuR to IRES in the 5 ' UTR.19, 20, 21 AREs mediate their effects on mRNA decay by first enhancing deadenylation (polyA shortening), a first step in mRNA decay facilitated by CCR4 and NOT and PAN2 and PAN complexes."
27251431
PAN2 affects nuclease
| 1
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN2 affects hydrogen sulfide
| 1
PAN2 activates hydrogen sulfide. 1 / 1
| 1
reach
"The paN2 allows Escherichia coli to liberate the sulfur of DBT and DBTs and pBADD produces a flavin reductase."
16736591
PAN2 bound to RBBP8 activates homologous recombination. 1 / 1
| 1
reach
"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
PAN2 affects hCG_1757335
1 |
PAN2 binds hCG_1757335. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects glucose
| 1
PAN2 activates glucose. 1 / 1
| 1
reach
"In a glucose-limited fed-batch fermentation, the PAN2* strain produced 19.5 g/L amino acids in 89 h, which was 16% higher than that produced by the parental D452-2 strain."
37272298
PAN2 affects cell cycle
| 1
PAN2 activates cell cycle. 1 / 1
| 1
reach
"USP52 promoted ASF1A stabilization facilitates chromatin assembly and favors cell cycle progression."
29599486
PAN2 affects ccr4Delta khd1Delta mutant [
| 1
PAN2 inhibits ccr4Delta khd1Delta mutant [. 1 / 1
| 1
reach
"We have previously reported that PAN2 overexpression from the multi-copy plasmid suppresses the growth defect of the ccr4Delta khd1Delta mutant [XREF_BIBR]."
28231297
PAN2 affects ZNF234
1 |
ZNF234 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects YWHAE
1 |
YWHAE binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects YUH1
| 1
PAN2 binds YUH1 and EXO. 1 / 1
| 1
sparser
"The lack of base-specific interactions between Pan2 UCH-Exo and adenines was surprising given that Pan2 displayed strong specificity against guanosines ( xref )."
31110294
PAN2 affects YES1
1 |
YES1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects YBX3
1 |
PAN2 binds YBX3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects YBX1
1 |
PAN2 binds YBX1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects XRN2
1 |
XRN2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects VIM
1 |
VIM binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects USP52in
| 1
PAN2 activates USP52in. 1 / 1
| 1
reach
"To investigate further the role of USP52in the HIF1A mediated hypoxic response, U2OS cells were treated with individual USP52 siRNA duplexes 1 and 3 and exposed to hypoxia."
23398456
PAN2 affects UBTD1
1 |
PAN2 binds UBTD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects UACA
1 |
UACA binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TXN
1 |
TXN binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUFM
1 |
TUFM binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUBB4B
1 |
PAN2 binds TUBB4B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUBB
1 |
PAN2 binds TUBB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUBA1B
1 |
TUBA1B binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUBA1A
1 |
PAN2 binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TRIM35
1 |
TRIM35 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23105109
PAN2 affects TRIM21
1 |
TRIM21 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TPM4
1 |
TPM4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TPM3P4
1 |
PAN2 binds TPM3P4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TPM3
1 |
TPM3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TPM1
1 |
TPM1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TP53
1 |
TP53 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TOB2
1 |
TOB2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
17785442
PAN2 affects TNRC6A
1 |
TNRC6A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
21984185
PAN2 affects TMOD3
1 |
TMOD3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TMOD2
1 |
TMOD2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TMOD1
1 |
TMOD1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TJP1
1 |
TJP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects THRAP3
1 |
PAN2 binds THRAP3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TFAM
1 |
TFAM binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TET2
1 |
PAN2 binds TET2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TCP1
1 |
TCP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TCOF1
1 |
TCOF1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SVIL
1 |
SVIL binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects STMN1
1 |
PAN2 binds STMN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects STK38L
1 |
STK38L binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects STING1
1 |
PAN2 binds STING1. 1 / 1
1 |
biogrid
No evidence text available
27801882
PAN2 affects SSBP1
1 |
SSBP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRSF8
1 |
SRSF8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRSF7
1 |
SRSF7 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRSF6
1 |
SRSF6 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRSF3
1 |
SRSF3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRRM2
1 |
SRRM2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRP14
1 |
SRP14 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SQSTM1
1 |
SQSTM1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SPTBN1
1 |
SPTBN1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SPTAN1
1 |
SPTAN1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SPECC1L
1 |
PAN2 binds SPECC1L. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SOWAHA
1 |
PAN2 binds SOWAHA. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects SNRPD2
1 |
SNRPD2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SNRPD1
1 |
SNRPD1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SNRPB
1 |
SNRPB binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SNRNP70
1 |
SNRNP70 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SMPDL3B
1 |
PAN2 binds SMPDL3B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SMN1
1 |
SMN1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SLC2A1
| 1
PAN2 inhibits SLC2A1. 1 / 1
| 1
reach
"Examination of GLUT1 and LDHA levels by immunoblot analysis of hypoxic U2OS cells revealed that USP52 depletion impairs the accumulation of GLUT1 and LDHA in response to hypoxia (XREF_FIG A), thus demonstrating that USP52 is required to potentiate the HIF1A mediated hypoxic response."
23398456
PAN2 affects SH3BGRL2
1 |
SH3BGRL2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SFPQ
1 |
SFPQ binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SF3B6
1 |
PAN2 binds SF3B6. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SF3A2
1 |
SF3A2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SERBP1
1 |
SERBP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SEC16A
1 |
PAN2 binds SEC16A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SART1
1 |
SART1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RUVBL2
1 |
RUVBL2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RRP1
1 |
RRP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RRAS2
1 |
RRAS2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS9
1 |
RPS9 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS8
1 |
RPS8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS7
1 |
RPS7 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS4X
1 |
RPS4X binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS3A
1 |
RPS3A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS3
1 |
RPS3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS26
1 |
RPS26 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS25
1 |
RPS25 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS24
1 |
RPS24 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS23
1 |
RPS23 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS2
1 |
RPS2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS19
1 |
RPS19 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS18
1 |
RPS18 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS17
1 |
RPS17 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS15A
1 |
RPS15A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS14
1 |
RPS14 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS12
1 |
RPS12 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS11
1 |
RPS11 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPLP0
1 |
RPLP0 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL7A
1 |
RPL7A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL7
1 |
RPL7 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL6
1 |
RPL6 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL5
1 |
RPL5 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL4
1 |
RPL4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL38
1 |
RPL38 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL37
1 |
RPL37 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL36A
1 |
RPL36A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL36
1 |
RPL36 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL35A
1 |
RPL35A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL35
1 |
RPL35 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL34
1 |
RPL34 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL32
1 |
RPL32 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL31
1 |
RPL31 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL30
1 |
RPL30 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL3
1 |
RPL3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL29
1 |
RPL29 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL28
1 |
RPL28 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL27A
1 |
RPL27A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL27
1 |
RPL27 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL26L1
1 |
RPL26L1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL26
1 |
RPL26 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL24
1 |
RPL24 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL23A
1 |
RPL23A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL23
1 |
RPL23 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL21
1 |
RPL21 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL19
1 |
RPL19 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL18A
1 |
RPL18A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL18
1 |
RPL18 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL17
1 |
RPL17 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL15
1 |
RPL15 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL13A
1 |
RPL13A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL13
1 |
RPL13 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL12
1 |
RPL12 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL10A
1 |
RPL10A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL10
1 |
RPL10 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPA2
1 |
RPA2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPA1
1 |
RPA1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RNF2
1 |
RNF2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects RNF144B
1 |
PAN2 binds RNF144B. 1 / 1
1 |
biogrid
No evidence text available
23105109
PAN2 affects RIOK1
1 |
RIOK1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RCN2
1 |
PAN2 binds RCN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RBM10
1 |
PAN2 binds RBM10. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RBCK1
1 |
RBCK1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23105109
PAN2 affects RBBP4
1 |
PAN2 binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RAI14
1 |
RAI14 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects Pbp1
| 1
PAN2 binds Pbp1. 1 / 1
| 1
reach
"29 Furthermore, the poly (A)-nuclease subunit Pan2 binds to Pbp1, 27 and the poly (A)-polymerase binding proteins Fir1 and Ufd1 interact with Pbp1 and have also been implicated in processing the 3 '-e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15663938
PAN2 affects PUF3C
| 1
PAN2 binds PUF3C. 1 / 1
| 1
reach
"We also assessed whether PUF3C could interact with PAN2."
20435044
PAN2 affects PTEN
| 1
PAN2 inhibits PTEN. 1 / 1
| 1
reach
"USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer."
34533198
PAN2 affects PSMC5
1 |
PAN2 binds PSMC5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PRNP
1 |
PAN2 binds PRNP. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PRMT5
1 |
PRMT5 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PPP1R12B
1 |
PAN2 binds PPP1R12B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PPP1R12A
1 |
PAN2 binds PPP1R12A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PPM1B
1 |
PAN2 binds PPM1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects POM121C
1 |
PAN2 binds POM121C. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects POM121
1 |
POM121 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects PKM
1 |
PAN2 binds PKM. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PKC
| 1
PKC binds PAN2 and PAN3. 1 / 1
| 1
sparser
"When we tested the interaction of the ct Pan2–Pan3 PKC complex with polyA RNA, the binding was comparable to ct Pan3 PKC alone (Fig  xref B)."
24872509
PAN2 affects PFDN2
1 |
PAN2 binds PFDN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects PCM1
1 |
PAN2 binds PCM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PCGF5
1 |
PAN2 binds PCGF5. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects PCGF3
1 |
PCGF3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects PCBP1
1 |
PAN2 binds PCBP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PAWR
1 |
PAN2 binds PAWR. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PARP1
1 |
PAN2 binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PAN3, ccr4, and exonuclease
| 1
PAN2 binds PAN3, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN2 affects PAN3, and ccr4
| 1
PAN2 binds PAN3 and ccr4. 1 / 1
| 1
sparser
"Interestingly, interactions between Pan2-Pan3 and Ccr4-Not can be detected suggesting that both deadenylase complexes can reside in a higher order complex that may include other components ( xref )."
24391663
PAN2 affects PAN3, and RNPC3
| 1
RNPC3 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
PAN2 affects PAN3, and PKC
| 1
PKC binds PAN2 and PAN3. 1 / 1
| 1
sparser
"When we tested the interaction of the ct Pan2–Pan3 PKC complex with polyA RNA, the binding was comparable to ct Pan3 PKC alone (Fig  xref B)."
24872509
PAN2 affects PACSIN3
1 |
PAN2 binds PACSIN3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PABPC4
1 |
PAN2 binds PABPC4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PABP
| 1
PAN2 binds PABP. 1 / 1
| 1
reach
"The modest amount of endogenous PABP in the precipitate (XREF_FIG) suggests an indirect association between HA-Pan2 and PABP, presumably mediated via Pan3-V5, as HA-Pan2 alone did not pull down PABP (XREF_FIG)."
18625844
PAN2 affects OFD1
1 |
PAN2 binds OFD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects Nanos
| 1
PAN2 binds Nanos. 1 / 1
| 1
reach
"Nanos interacted with NOT1, NOT2, NOT3, PAN2, and PAN3 (Figs XREF_FIG A-D and XREF_FIG G-M)."
26968986
PAN2 affects NUP93
1 |
PAN2 binds NUP93. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects NUP50
1 |
PAN2 binds NUP50. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects NSMCE2
1 |
PAN2 binds NSMCE2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects NPM1
1 |
PAN2 binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects NOLC1
1 |
NOLC1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects NISCH
1 |
NISCH binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects NEXN
1 |
PAN2 binds NEXN. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects NCL
1 |
PAN2 binds NCL. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO6
1 |
PAN2 binds MYO6. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO5C
1 |
PAN2 binds MYO5C. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO5B
1 |
PAN2 binds MYO5B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO5A
1 |
PAN2 binds MYO5A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO1E
1 |
PAN2 binds MYO1E. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO1D
1 |
PAN2 binds MYO1D. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO1C
1 |
PAN2 binds MYO1C. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO1B
1 |
PAN2 binds MYO1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO18A
1 |
PAN2 binds MYO18A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO10
1 |
PAN2 binds MYO10. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYL6B
1 |
PAN2 binds MYL6B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYL12B
1 |
PAN2 binds MYL12B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYH9
1 |
PAN2 binds MYH9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYH14
1 |
PAN2 binds MYH14. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYH10
1 |
PAN2 binds MYH10. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYCBP
1 |
PAN2 binds MYCBP. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MTA2
| 1
PAN2 binds PAN3 and MTA2. 1 / 1
| 1
sparser
"In summary, we found that it was difficult to disrupt the Pan2–Pan3 interaction by deletion of substantial regions of ct Pan2 PID and show that a core region (residues 343–406) makes a major contribution to the association of ct Pan2 and ct Pan3."
24872509
PAN2 affects MT1M
1 |
MT1M binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MEX3C
1 |
PAN2 binds MEX3C. 1 / 1
1 |
biogrid
No evidence text available
26471122
PAN2 affects MARCKSL1
1 |
PAN2 binds MARCKSL1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MAP1B
1 |
PAN2 binds MAP1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LZTS2
1 |
PAN2 binds LZTS2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LYN
1 |
PAN2 binds LYN. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LSM1
1 |
PAN2 binds LSM1. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects LMNB2
1 |
PAN2 binds LMNB2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LIMA1
1 |
PAN2 binds LIMA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LGALS8
1 |
PAN2 binds LGALS8. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LDHA
| 1
PAN2 inhibits LDHA. 1 / 1
| 1
reach
"Examination of GLUT1 and LDHA levels by immunoblot analysis of hypoxic U2OS cells revealed that USP52 depletion impairs the accumulation of GLUT1 and LDHA in response to hypoxia (XREF_FIG A), thus demonstrating that USP52 is required to potentiate the HIF1A mediated hypoxic response."
23398456
PAN2 affects KRT9
1 |
PAN2 binds KRT9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRT6A
1 |
PAN2 binds KRT6A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRT2
1 |
PAN2 binds KRT2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRT19
1 |
PAN2 binds KRT19. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRT18
1 |
PAN2 binds KRT18. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRT10
1 |
PAN2 binds KRT10. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KIF11
1 |
PAN2 binds KIF11. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KIAA1671
1 |
PAN2 binds KIAA1671. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects KCTD5
1 |
PAN2 binds KCTD5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects JUP
1 |
PAN2 binds JUP. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects IVNS1ABP
1 |
IVNS1ABP binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects IRS4
1 |
PAN2 binds IRS4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects INA
1 |
PAN2 binds INA. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects IGKV2-40
1 |
PAN2 binds IGKV2-40. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects IGHG2
1 |
PAN2 binds IGHG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects IGF2BP1
1 |
PAN2 binds IGF2BP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSPD1
1 |
PAN2 binds HSPD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSPA9
1 |
PAN2 binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSPA8
1 |
PAN2 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSPA5
1 |
PAN2 binds HSPA5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSPA1A
1 |
PAN2 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSP90AB1
1 |
PAN2 binds HSP90AB1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSP90AA1
1 |
PAN2 binds HSP90AA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPU
1 |
PAN2 binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPM
1 |
PAN2 binds HNRNPM. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPH1
1 |
PAN2 binds HNRNPH1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPD
1 |
PAN2 binds HNRNPD. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPA3
1 |
PAN2 binds HNRNPA3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPA2B1
1 |
PAN2 binds HNRNPA2B1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPA1
1 |
PAN2 binds HNRNPA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HMGA1
1 |
PAN2 binds HMGA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HIF-1alpha mRNA
| 1
PAN2 activates HIF-1alpha mRNA. 1 / 1
| 1
eidos
"Thereby , depletion of USP52 reduced the HIF-1alpha mRNA levels via a 3 ' - untranslated region-dependent but poly ( A ) - tail-length-independent interference mechanism , with the effect that HIF-1alpha-regulated hypoxic targets were expressed at a lower level [ 124 ] ."
31208103
PAN2 affects HELZ
1 |
HELZ binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects HBB
1 |
PAN2 binds HBB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HBA1
1 |
PAN2 binds HBA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HADHB
1 |
PAN2 binds HADHB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HADHA
1 |
PAN2 binds HADHA. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects H4C1
1 |
PAN2 binds H4C1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects H2BS1
1 |
PAN2 binds H2BS1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects H2AZ1
1 |
PAN2 binds H2AZ1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects H1-4
1 |
PAN2 binds H1-4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GST50DeltaC
| 1
PAN2 binds GST50DeltaC. 1 / 1
| 1
reach
"In contrast, preincubation of GST50DeltaC with the irrelevant oligomer, GBL, failed to inhibit the formation of the GST50DeltaC and PAN2 complexes."
12788632
PAN2 affects GNG12
1 |
GNG12 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GNB4
1 |
PAN2 binds GNB4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GNB2
1 |
PAN2 binds GNB2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GNB1
1 |
PAN2 binds GNB1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GNAI3
1 |
PAN2 binds GNAI3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GNAI2
1 |
PAN2 binds GNAI2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GLG1
1 |
PAN2 binds GLG1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects FUS
| 1
PAN2 binds FUS. 1 / 1
| 1
reach
"Moreover, CPSF6 and PAN2 interacted with FUS both in the presence and absence of RNase A, indicating that they form an RNA independent protein complex (XREF_FIG)."
25968143
PAN2 affects FLII
1 |
PAN2 binds FLII. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects FBL
1 |
PAN2 binds FBL. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects FARSA
1 |
PAN2 binds FARSA. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EXO
| 1
PAN2 binds YUH1 and EXO. 1 / 1
| 1
sparser
"The lack of base-specific interactions between Pan2 UCH-Exo and adenines was surprising given that Pan2 displayed strong specificity against guanosines ( xref )."
31110294
PAN2 affects ERF
1 |
PAN2 binds ERF. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects EMD
1 |
PAN2 binds EMD. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ELOC
1 |
ELOC binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects ELOB
1 |
ELOB binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects ELAVL1
1 |
PAN2 binds ELAVL1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF4ENIF1
1 |
biogrid
No evidence text available
27173435
PAN2 affects EIF4B
1 |
PAN2 binds EIF4B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF3I
1 |
PAN2 binds EIF3I. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF3H
1 |
PAN2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF3G
1 |
PAN2 binds EIF3G. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF3B
1 |
PAN2 binds EIF3B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EFTUD2
1 |
PAN2 binds EFTUD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EFHD2
1 |
PAN2 binds EFHD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EFHD1
1 |
PAN2 binds EFHD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EEF1G
1 |
PAN2 binds EEF1G. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EBF3
1 |
EBF3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects DYNLL1
1 |
DYNLL1 binds PAN2. 1 / 1
1 |
hprd
No evidence text available
11148209
PAN2 affects DSG2
1 |
PAN2 binds DSG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DOCK7
1 |
DOCK7 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DNAJA2
1 |
DNAJA2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DNAJA1
1 |
PAN2 binds DNAJA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DNA resection
| 1
PAN2 inhibits DNA resection. 1 / 1
| 1
eidos
"Here , we identify that USP52 directly interacts with and deubiquitinates CtIP , thereby promoting DNA end resection and HR ."
33097710
PAN2 affects DHX9
1 |
PAN2 binds DHX9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DBT
| 1
PAN2 activates DBT. 1 / 1
| 1
reach
"The paN2 allows Escherichia coli to liberate the sulfur of DBT and DBTs and pBADD produces a flavin reductase."
16736591
PAN2 affects DBN1
1 |
PAN2 binds DBN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CTTN
1 |
PAN2 binds CTTN. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CTNNA2
1 |
PAN2 binds CTNNA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CREBBP
1 |
PAN2 binds CREBBP. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects CORO1C
1 |
PAN2 binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects COL1A2
1 |
PAN2 binds COL1A2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CNN3
1 |
PAN2 binds CNN3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CNN2
1 |
PAN2 binds CNN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CNBP
1 |
CNBP binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CMBL
1 |
PAN2 binds CMBL. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLTC
1 |
PAN2 binds CLTC. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLTB
1 |
PAN2 binds CLTB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLTA
1 |
PAN2 binds CLTA. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLNS1A
1 |
PAN2 binds CLNS1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLINT1
1 |
PAN2 binds CLINT1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CFL2
1 |
CFL2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CEP170
1 |
PAN2 binds CEP170. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CD59
1 |
CD59 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT8
1 |
CCT8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT6A
1 |
CCT6A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT5
1 |
CCT5 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT4
1 |
CCT4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT3
1 |
CCT3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT2
1 |
CCT2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CBWD2
1 |
CBWD2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects CAPZB
1 |
CAPZB binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CAPZA2
1 |
CAPZA2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CAPZA1
1 |
CAPZA1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CALM1
1 |
CALM1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CALD1
1 |
CALD1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects C15orf39
1 |
PAN2 binds C15orf39. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects BOLA2
1 |
PAN2 binds BOLA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects BLNK
| 1
BLNK binds PAN2, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
PAN2 affects BASP1
1 |
PAN2 binds BASP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects BAG2
1 |
PAN2 binds BAG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ATP6V1B2
1 |
PAN2 binds ATP6V1B2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ATP5F1A
1 |
PAN2 binds ATP5F1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ASF1B
1 |
PAN2 binds ASF1B. 1 / 1
1 |
biogrid
No evidence text available
28514442
PAN2 affects ARPC1B
1 |
PAN2 binds ARPC1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ARID3A
1 |
PAN2 binds ARID3A. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects ARCN1
1 |
PAN2 binds ARCN1. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects AP2A2
1 |
PAN2 binds AP2A2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ALYREF
1 |
ALYREF binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects AIMP1
1 |
AIMP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects AIFM1
1 |
PAN2 binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ACTR3B
1 |
ACTR3B binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ACTC1
1 |
ACTC1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ACTB
1 |
ACTB binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PACSIN3 affects PAN2
1 |
PAN2 binds PACSIN3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PABPC4 affects PAN2
1 |
PAN2 binds PABPC4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PABPC1 affects RNPC3
| 1
RNPC3 binds PAN2 and PABPC1. 1 / 1
| 1
sparser
"At the oligomerization interface between the second and third Pab1, the RNP interacts with the WD40 domain of Pan2 at a conserved surface of the base of the β-propeller ( xref A and xref A)."
31104843
PABPC1 affects PAN3
1 |
PAN2 binds PAN3 and PABPC1. 1 / 1
1 |
hprd
No evidence text available
18056425
PABPC1 affects PAN2, and RNPC3
| 1
RNPC3 binds PAN2 and PABPC1. 1 / 1
| 1
sparser
"At the oligomerization interface between the second and third Pab1, the RNP interacts with the WD40 domain of Pan2 at a conserved surface of the base of the β-propeller ( xref A and xref A)."
31104843
PABPC1 affects PAN2, and PAN3
1 |
PAN2 binds PAN3 and PABPC1. 1 / 1
1 |
hprd
No evidence text available
18056425
OFD1 affects PAN2
1 |
PAN2 binds OFD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
Nanos affects PAN2
| 1
PAN2 binds Nanos. 1 / 1
| 1
reach
"Nanos interacted with NOT1, NOT2, NOT3, PAN2, and PAN3 (Figs XREF_FIG A-D and XREF_FIG G-M)."
26968986
NUP93 affects PAN2
1 |
PAN2 binds NUP93. 1 / 1
1 |
biogrid
No evidence text available
19615732
NUP50 affects PAN2
1 |
PAN2 binds NUP50. 1 / 1
1 |
biogrid
No evidence text available
27173435
NSMCE2 affects PAN2
1 |
PAN2 binds NSMCE2. 1 / 1
1 |
biogrid
No evidence text available
23398456
NR3C1 affects PAN2
1 |
NR3C1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
NR2F2 affects PAN2
1 |
NR2F2 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
NPM1 affects PAN2
1 |
PAN2 binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
NOLC1 affects PAN2
1 |
NOLC1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
NISCH affects PAN2
1 |
NISCH binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
NEXN affects PAN2
1 |
PAN2 binds NEXN. 1 / 1
1 |
biogrid
No evidence text available
23398456
NCL affects PAN2
1 |
PAN2 binds NCL. 1 / 1
1 |
biogrid
No evidence text available
23398456
N-ethylmaleimide affects PAN2
| 1
reach
"Although the conserved cysteine residue in the triad of classical DUBs is replaced by alanine (A526) in the UCH domain of USP52, we demonstrated that addition of the alkylating reagent N-ethylmaleimide (NEM), a known inhibitor of cysteine proteases XREF_BIBR, XREF_BIBR, almost completely abolished the catalytic activity of USP52 against K48- or K63 linked tetra-ubiquitins."
29599486
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal activates PAN2. 1 / 1
| 1
reach
"In order to exclude USP52 knockdown promoting HIF1A depletion through alternative degradation pathways, U2OS cells depleted of USP52 were treated with the proteasome inhibitor MG132."
23398456
MYO6 affects PAN2
1 |
PAN2 binds MYO6. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO5C affects PAN2
1 |
PAN2 binds MYO5C. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO5B affects PAN2
1 |
PAN2 binds MYO5B. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO5A affects PAN2
1 |
PAN2 binds MYO5A. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO1E affects PAN2
1 |
PAN2 binds MYO1E. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO1D affects PAN2
1 |
PAN2 binds MYO1D. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO1C affects PAN2
1 |
PAN2 binds MYO1C. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO1B affects PAN2
1 |
PAN2 binds MYO1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO18A affects PAN2
1 |
PAN2 binds MYO18A. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO10 affects PAN2
1 |
PAN2 binds MYO10. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYL6B affects PAN2
1 |
PAN2 binds MYL6B. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYL12B affects PAN2
1 |
PAN2 binds MYL12B. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYH9 affects PAN2
1 |
PAN2 binds MYH9. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYH14 affects PAN2
1 |
PAN2 binds MYH14. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYH10 affects PAN2
1 |
PAN2 binds MYH10. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYCBP affects PAN2
1 |
PAN2 binds MYCBP. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYB affects PAN2
1 |
MYB decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
MTA2 affects PAN3
| 1
PAN2 binds PAN3 and MTA2. 1 / 1
| 1
sparser
"In summary, we found that it was difficult to disrupt the Pan2–Pan3 interaction by deletion of substantial regions of ct Pan2 PID and show that a core region (residues 343–406) makes a major contribution to the association of ct Pan2 and ct Pan3."
24872509
MT1M affects PAN2
1 |
MT1M binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
MEX3C affects PAN2
1 |
PAN2 binds MEX3C. 1 / 1
1 |
biogrid
No evidence text available
26471122
MARF1 affects PAN3
| 1
PAN2 binds MARF1 and PAN3. 1 / 1
| 1
sparser
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
30279526
MARCKSL1 affects PAN2
1 |
PAN2 binds MARCKSL1. 1 / 1
1 |
biogrid
No evidence text available
23398456
MAP1B affects PAN2
1 |
PAN2 binds MAP1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
LZTS2 affects PAN2
1 |
PAN2 binds LZTS2. 1 / 1
1 |
biogrid
No evidence text available
23398456
LYN affects PAN2
1 |
PAN2 binds LYN. 1 / 1
1 |
biogrid
No evidence text available
23398456
LSM1 affects PAN2
1 |
PAN2 binds LSM1. 1 / 1
1 |
biogrid
No evidence text available
27173435
LMNB2 affects PAN2
1 |
PAN2 binds LMNB2. 1 / 1
1 |
biogrid
No evidence text available
23398456
LIMA1 affects PAN2
1 |
PAN2 binds LIMA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
LGALS8 affects PAN2
1 |
PAN2 binds LGALS8. 1 / 1
1 |
biogrid
No evidence text available
23398456
L-thyroxine affects PAN2
| 1
L-thyroxine activates PAN2. 1 / 1
| 1
reach
"The PCR product from the Pan 2 reaction was treated with T4 DNA polymerase (Pharmacia) to blunt the ends, and then digested with BamHl."
8124711
KRT9 affects PAN2
1 |
PAN2 binds KRT9. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRT6A affects PAN2
1 |
PAN2 binds KRT6A. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRT2 affects PAN2
1 |
PAN2 binds KRT2. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRT19 affects PAN2
1 |
PAN2 binds KRT19. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRT18 affects PAN2
1 |
PAN2 binds KRT18. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRT10 affects PAN2
1 |
PAN2 binds KRT10. 1 / 1
1 |
biogrid
No evidence text available
23398456
KIF11 affects PAN2
1 |
PAN2 binds KIF11. 1 / 1
1 |
biogrid
No evidence text available
23398456
KIAA1671 affects PAN2
1 |
PAN2 binds KIAA1671. 1 / 1
1 |
biogrid
No evidence text available
27173435
KCTD5 affects PAN2
1 |
PAN2 binds KCTD5. 1 / 1
1 |
biogrid
No evidence text available
23398456
JUP affects PAN2
1 |
PAN2 binds JUP. 1 / 1
1 |
biogrid
No evidence text available
23398456
IVNS1ABP affects PAN2
1 |
IVNS1ABP binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
IRS4 affects PAN2
1 |
PAN2 binds IRS4. 1 / 1
1 |
biogrid
No evidence text available
23398456
INA affects PAN2
1 |
PAN2 binds INA. 1 / 1
1 |
biogrid
No evidence text available
23398456
IGKV2-40 affects PAN2
1 |
PAN2 binds IGKV2-40. 1 / 1
1 |
biogrid
No evidence text available
23398456
IGHG2 affects PAN2
1 |
PAN2 binds IGHG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
IGF2BP1 affects PAN2
1 |
PAN2 binds IGF2BP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSPD1 affects PAN2
1 |
PAN2 binds HSPD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSPA9 affects PAN2
1 |
PAN2 binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSPA8 affects PAN2
1 |
PAN2 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSPA5 affects PAN2
1 |
PAN2 binds HSPA5. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSPA1A affects PAN2
1 |
PAN2 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSP90AB1 affects PAN2
1 |
PAN2 binds HSP90AB1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSP90AA1 affects PAN2
1 |
PAN2 binds HSP90AA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPU affects PAN2
1 |
PAN2 binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPM affects PAN2
1 |
PAN2 binds HNRNPM. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPH1 affects PAN2
1 |
PAN2 binds HNRNPH1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPD affects PAN2
1 |
PAN2 binds HNRNPD. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPA3 affects PAN2
1 |
PAN2 binds HNRNPA3. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPA2B1 affects PAN2
1 |
PAN2 binds HNRNPA2B1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPA1 affects PAN2
1 |
PAN2 binds HNRNPA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HIF1A affects PAN2
| 1
PAN2 binds HIF1A. 1 / 1
| 1
sparser
"In order to determine whether the effect of USP52 depletion on HIF1A mRNA stability was associated with a change in HIF1A poly(A) tail length, we analysed poly(A) tail length in U2OS cells treated with NT or USP52 siRNA."
23398456
HELZ affects PAN2
1 |
HELZ binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
HBB affects PAN2
1 |
PAN2 binds HBB. 1 / 1
1 |
biogrid
No evidence text available
23398456
HBA1 affects PAN2
1 |
PAN2 binds HBA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HAND1 affects PAN2
1 |
HAND1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
HADHB affects PAN2
1 |
PAN2 binds HADHB. 1 / 1
1 |
biogrid
No evidence text available
23398456
HADHA affects PAN2
1 |
PAN2 binds HADHA. 1 / 1
1 |
biogrid
No evidence text available
23398456
H4C1 affects PAN2
1 |
PAN2 binds H4C1. 1 / 1
1 |
biogrid
No evidence text available
23398456
H2BS1 affects PAN2
1 |
PAN2 binds H2BS1. 1 / 1
1 |
biogrid
No evidence text available
23398456
H2AZ1 affects PAN2
1 |
PAN2 binds H2AZ1. 1 / 1
1 |
biogrid
No evidence text available
23398456
H1-4 affects PAN2
1 |
PAN2 binds H1-4. 1 / 1
1 |
biogrid
No evidence text available
23398456
GST50DeltaC affects PAN2
| 1
PAN2 binds GST50DeltaC. 1 / 1
| 1
reach
"In contrast, preincubation of GST50DeltaC with the irrelevant oligomer, GBL, failed to inhibit the formation of the GST50DeltaC and PAN2 complexes."
12788632
GNG12 affects PAN2
1 |
GNG12 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
GNB4 affects PAN2
1 |
PAN2 binds GNB4. 1 / 1
1 |
biogrid
No evidence text available
23398456
GNB2 affects PAN2
1 |
PAN2 binds GNB2. 1 / 1
1 |
biogrid
No evidence text available
23398456
GNB1 affects PAN2
1 |
PAN2 binds GNB1. 1 / 1
1 |
biogrid
No evidence text available
23398456
GNAI3 affects PAN2
1 |
PAN2 binds GNAI3. 1 / 1
1 |
biogrid
No evidence text available
23398456
GNAI2 affects PAN2
1 |
PAN2 binds GNAI2. 1 / 1
1 |
biogrid
No evidence text available
23398456
GLG1 affects PAN2
1 |
PAN2 binds GLG1. 1 / 1
1 |
biogrid
No evidence text available
23398456
GATA1 affects PAN2
1 |
GATA1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
FLII affects PAN2
1 |
PAN2 binds FLII. 1 / 1
1 |
biogrid
No evidence text available
23398456
FBL affects PAN2
1 |
PAN2 binds FBL. 1 / 1
1 |
biogrid
No evidence text available
23398456
FARSA affects PAN2
1 |
PAN2 binds FARSA. 1 / 1
1 |
biogrid
No evidence text available
23398456
EXO affects YUH1
| 1
PAN2 binds YUH1 and EXO. 1 / 1
| 1
sparser
"The lack of base-specific interactions between Pan2 UCH-Exo and adenines was surprising given that Pan2 displayed strong specificity against guanosines ( xref )."
31110294
ERF affects PAN2
1 |
PAN2 binds ERF. 1 / 1
1 |
biogrid
No evidence text available
27173435
EMD affects PAN2
1 |
PAN2 binds EMD. 1 / 1
1 |
biogrid
No evidence text available
23398456
ELOC affects PAN2
1 |
ELOC binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
ELOB affects PAN2
1 |
ELOB binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
ELAVL1 affects PAN2
1 |
PAN2 binds ELAVL1. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF4ENIF1 affects PAN2
1 |
biogrid
No evidence text available
27173435
EIF4B affects PAN2
1 |
PAN2 binds EIF4B. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3I affects PAN2
1 |
PAN2 binds EIF3I. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3H affects PAN2
1 |
PAN2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3G affects PAN2
1 |
PAN2 binds EIF3G. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3B affects PAN2
1 |
PAN2 binds EIF3B. 1 / 1
1 |
biogrid
No evidence text available
23398456
EFTUD2 affects PAN2
1 |
PAN2 binds EFTUD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
EFHD2 affects PAN2
1 |
PAN2 binds EFHD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
EFHD1 affects PAN2
1 |
PAN2 binds EFHD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
EEF1G affects PAN2
1 |
PAN2 binds EEF1G. 1 / 1
1 |
biogrid
No evidence text available
23398456
EBF3 affects PAN2
1 |
EBF3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
DYNLL1 affects PAN2
1 |
DYNLL1 binds PAN2. 1 / 1
1 |
hprd
No evidence text available
11148209
DSG2 affects PAN2
1 |
PAN2 binds DSG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
DOCK7 affects PAN2
1 |
DOCK7 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
DNAJA2 affects PAN2
1 |
DNAJA2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
DNAJA1 affects PAN2
1 |
PAN2 binds DNAJA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
DHX9 affects PAN2
1 |
PAN2 binds DHX9. 1 / 1
1 |
biogrid
No evidence text available
23398456
DHUs poly A tail affects PAN2
| 1
DHUs poly A tail inhibits PAN2. 1 / 1
| 1
eidos
"The introduction of two DHUs into a poly ( A ) tail strongly inhibits Pan2 activity relative to two uracils , which only cause a slight stall in deadenylation ( Fig. 4C ; Tang et al. 2019 ) ."
32295929
DBN1 affects PAN2
1 |
PAN2 binds DBN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
CTTN affects PAN2
1 |
PAN2 binds CTTN. 1 / 1
1 |
biogrid
No evidence text available
23398456
CTNNA2 affects PAN2
1 |
PAN2 binds CTNNA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CREBBP affects PAN2
1 |
PAN2 binds CREBBP. 1 / 1
1 |
biogrid
No evidence text available
27173435
CORO1C affects PAN2
1 |
PAN2 binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
23398456
COL1A2 affects PAN2
1 |
PAN2 binds COL1A2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CNOT7 affects nuclease
| 1
CNOT7 binds PAN2, PAN3, nuclease, and ccr4. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
CNN3 affects PAN2
1 |
PAN2 binds CNN3. 1 / 1
1 |
biogrid
No evidence text available
23398456
CNN2 affects PAN2
1 |
PAN2 binds CNN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CNBP affects PAN2
1 |
CNBP binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CMBL affects PAN2
1 |
PAN2 binds CMBL. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLTC affects PAN2
1 |
PAN2 binds CLTC. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLTB affects PAN2
1 |
PAN2 binds CLTB. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLTA affects PAN2
1 |
PAN2 binds CLTA. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLNS1A affects PAN2
1 |
PAN2 binds CLNS1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLINT1 affects PAN2
1 |
PAN2 binds CLINT1. 1 / 1
1 |
biogrid
No evidence text available
23398456
CFL2 affects PAN2
1 |
CFL2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CEP170 affects PAN2
1 |
PAN2 binds CEP170. 1 / 1
1 |
biogrid
No evidence text available
23398456
CD59 affects PAN2
1 |
CD59 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT8 affects PAN2
1 |
CCT8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT6A affects PAN2
1 |
CCT6A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT5 affects PAN2
1 |
CCT5 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT4 affects PAN2
1 |
CCT4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT3 affects PAN2
1 |
CCT3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT2 affects PAN2
1 |
CCT2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CBWD2 affects PAN2
1 |
CBWD2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
CAPZB affects PAN2
1 |
CAPZB binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CAPZA2 affects PAN2
1 |
CAPZA2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CAPZA1 affects PAN2
1 |
CAPZA1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CALM1 affects PAN2
1 |
CALM1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CALD1 affects PAN2
1 |
CALD1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
C646 compound affects PAN2
1 |
C646 compound increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
26191083
C15orf39 affects PAN2
1 |
PAN2 binds C15orf39. 1 / 1
1 |
biogrid
No evidence text available
27173435
BOLA2 affects PAN2
1 |
PAN2 binds BOLA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
BLNK affects exonuclease
| 1
BLNK binds PAN2, exonuclease, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
BASP1 affects PAN2
1 |
PAN2 binds BASP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
BAG2 affects PAN2
1 |
PAN2 binds BAG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
Aroclor 1254 affects PAN2
1 |
Aroclor 1254 decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23650126
Air Pollutants affects PAN2
1 |
Air Pollutants decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
21757418
ATP6V1B2 affects PAN2
1 |
PAN2 binds ATP6V1B2. 1 / 1
1 |
biogrid
No evidence text available
23398456
ATP5F1A affects PAN2
1 |
PAN2 binds ATP5F1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
ASF1B affects PAN2
1 |
PAN2 binds ASF1B. 1 / 1
1 |
biogrid
No evidence text available
28514442
ARPC1B affects PAN2
1 |
PAN2 binds ARPC1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
ARID3A affects PAN2
1 |
PAN2 binds ARID3A. 1 / 1
1 |
biogrid
No evidence text available
27173435
ARCN1 affects PAN2
1 |
PAN2 binds ARCN1. 1 / 1
1 |
biogrid
No evidence text available
19615732
AP2A2 affects PAN2
1 |
PAN2 binds AP2A2. 1 / 1
1 |
biogrid
No evidence text available
23398456
ALYREF affects PAN2
1 |
ALYREF binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
AIMP1 affects PAN2
1 |
AIMP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
AIFM1 affects PAN2
1 |
PAN2 binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
ACTR3B affects PAN2
1 |
ACTR3B binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
ACTC1 affects PAN2
1 |
ACTC1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
ACTB affects PAN2
1 |
ACTB binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
2,3,7,8-tetrachlorodibenzodioxine increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
17942748
17alpha-ethynylestradiol increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
17942748