IndraLab

Statements

PAN3 affects PAN2
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PAN3 binds PAN2.
1 19 2 | 120 210
PAN2 binds PAN3. 10 / 327
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"In humans, TNRC6C also independently interacts with the PAN2 and PAN3 complex and contributes to gene silencing by miRNA."
24904636
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"Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation."
24872509
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"This binding allows Pan3 to supply Pan2 with substrate polyA RNA, facilitating efficient mRNA deadenylation by the intact Pan2 and Pan3 complex."
24872509
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"The mechanism of Pan2 and Pan3 complex formation and substrate binding remain elusive."
24872509
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"Recent work showed that Pan3 forms a homodimer in solution (Christie etal, 2013) raising the question of whether the Pan2 and Pan3 complex contains one or two exonuclease subunits."
24872509
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"The poly (A) tail degrading enzyme Pan2-Pan3 complex has been reported to be inhibited by Pbp1 [ xref ]."
33984024
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"To examine whether the Pan2-Pan3 complex controls COX10 , COX11 , and AIM33 mRNA, we prepared the pbp1Δ pan2Δ double mutant and then performed qRT-PCR analysis."
33984024
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"These results suggest that Pbp1 does not regulate the expression of COX10 , COX11 , and AIM33 mRNAs through the Pan2-Pan3 complex."
33984024
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"From the above results, Pbp1 can stabilize COX10 , COX11 , and AIM33 mRNAs by inhibiting decapping factors rather than acting on deadenylases, the Ccr4-Not and Pan2-Pan3 complexes."
33984024
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"Two other Drosophila poly(A)-specific ribonucleases, the Pan2-Pan3 complex and the poly(A)-specific ribonuclease (PARN), have both specialized and redundant functions when compared to the CCR4-NOT com[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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PAN2 binds PAN3. 10 / 12
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24880344
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11805826
PAN3 binds CNOT7, PAN2, and ccr4. 5 / 5
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"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
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"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
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"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
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"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
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"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
PAN3 binds PAN2. 2 / 2
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MARF1 binds PAN2 and PAN3. 1 / 1
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"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
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Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
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"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
MTA2 binds PAN3 and PAN2. 1 / 1
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"In summary, we found that it was difficult to disrupt the Pan2–Pan3 interaction by deletion of substantial regions of ct Pan2 PID and show that a core region (residues 343–406) makes a major contribution to the association of ct Pan2 and ct Pan3."
24872509
PABPC1 binds PAN2 and PAN3. 1 / 1
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PAN3 binds PAN2 and RNPC3. 1 / 1
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"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
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PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
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"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN3 inhibits PAN2.
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PAN3 inhibits PAN2. 1 / 2
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"It is therefore a possibility that PAN3 depletion prevents USP52 localization to P-bodies and thus contributes to the destabilization of AMD substrates, as we have observed in the case of HIF1A."
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PAN3 activates PAN2.
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PAN3 activates PAN2. 2 / 2
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"Instead, Pan3 may modulate the activity of Pan2 poly (A) nuclease or link deadenylation to subsequent decay of the mRNA body."
18625844
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"Because Pan3 is able to enhance localization of Pan2 to P-bodies (XREF_FIG), we then tested whether Pan3 also helps Ccr4 and Caf1 localize to P-bodies."
18625844
NLRP6 affects PAN2
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NLRP6 binds PAN2.
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PAN2 binds NLRP6. 10 / 93
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"Two major complexes are involved in mRNA deadenylation: the Ccr4/Pop2/Not complex and Pan2/Pan3 complex [16] ."
24946962
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"In addition, YTHDF3 coimmunoprecipitated with PAN3 ( Figure 2 C), demonstrating that YTHDF3 recruits the PAN2-PAN3 complex to digest poly(A) via an RNA decay pathway different from that used by YTHDF2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32905781
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"Overexpression of only YTHDF2 could rescue the phenotype ( Figures 2 D, 2E, and S2 H), suggesting that the function of YTHDF3 depends on the PAN2-PAN3 complex."
32905781
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"Although the PAN2-PAN3 complex can associate with the CCR4-NOT complex ( Zheng et al., 2008 ), the molecular details and mechanism for the consecutive action of these complexes are unclear.The PAN2-PA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23932717
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"Deadenylation is therefore the major step in controlling mRNA decay and as such is highly regulated.Three enzymes with deadenylase activity are present in most species, the CCR4-NOT complex, the PAN2-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23298642
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"In this review, we will focus on the main cytoplasmic deadenylases: the Pan2–Pan3 complex and the multisubunit Ccr4–Not complex."
23337855
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"In plants, the PAN2–PAN3 complex has not yet been identified."
28011423
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"First, the catalytic subunit of the PAN2–PAN3 complex PAN2 mediates the initial rapid deadenylation, followed by two subunits of the CCR4–NOT complex, CCR4 and CAF1, most likely shortening the poly(A)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36933704
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"The Pan2–Pan3 complex consists of catalytic subunit Pan2 and regulatory subunit Pan3 [10] , and both the Caf1 and Ccr4 subunits exhibit the catalytic activity of deadenylase [11–13] ."
25446091
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"These results demonstrate that the Caf1–Ccr4–Tob complex, but not the Pan2–Pan3 complex, is responsible for c-myc mRNA deadenylation."
25446091
NLRP6 phosphorylates PAN2.
| 1
NLRP6 phosphorylates PAN2. 1 / 1
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"Since Ccr4, Pan2, and Pan3 seem to be more phosphorylated in GlyLac medium, these phosphorylated Ccr4, Pan2, and Pan3 proteins might be required to maintain a proper homeostasis in low energy media.In[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34280615
NLRP6 activates PAN2.
| 1
NLRP6 activates PAN2. 1 / 1
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"Semi-quantitative assays indicate that, in the spermidine-dependent reaction in the absence of PABPC, Pan2 is but modestly stimulated by Pan3 [66] ; it remains to be determined whether Pan3 in fact ha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23337855
PAN2 affects NLRP6
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PAN2 binds NLRP6.
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PAN2 binds NLRP6. 10 / 93
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"Two major complexes are involved in mRNA deadenylation: the Ccr4/Pop2/Not complex and Pan2/Pan3 complex [16] ."
24946962
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"In addition, YTHDF3 coimmunoprecipitated with PAN3 ( Figure 2 C), demonstrating that YTHDF3 recruits the PAN2-PAN3 complex to digest poly(A) via an RNA decay pathway different from that used by YTHDF2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32905781
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"Overexpression of only YTHDF2 could rescue the phenotype ( Figures 2 D, 2E, and S2 H), suggesting that the function of YTHDF3 depends on the PAN2-PAN3 complex."
32905781
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"Although the PAN2-PAN3 complex can associate with the CCR4-NOT complex ( Zheng et al., 2008 ), the molecular details and mechanism for the consecutive action of these complexes are unclear.The PAN2-PA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23932717
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"Deadenylation is therefore the major step in controlling mRNA decay and as such is highly regulated.Three enzymes with deadenylase activity are present in most species, the CCR4-NOT complex, the PAN2-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23298642
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"In this review, we will focus on the main cytoplasmic deadenylases: the Pan2–Pan3 complex and the multisubunit Ccr4–Not complex."
23337855
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"In plants, the PAN2–PAN3 complex has not yet been identified."
28011423
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"First, the catalytic subunit of the PAN2–PAN3 complex PAN2 mediates the initial rapid deadenylation, followed by two subunits of the CCR4–NOT complex, CCR4 and CAF1, most likely shortening the poly(A)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36933704
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"The Pan2–Pan3 complex consists of catalytic subunit Pan2 and regulatory subunit Pan3 [10] , and both the Caf1 and Ccr4 subunits exhibit the catalytic activity of deadenylase [11–13] ."
25446091
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"These results demonstrate that the Caf1–Ccr4–Tob complex, but not the Pan2–Pan3 complex, is responsible for c-myc mRNA deadenylation."
25446091
PAN2 phosphorylates NLRP6.
| 1
PAN2 phosphorylates NLRP6. 1 / 1
| 1
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"Since Ccr4, Pan2, and Pan3 seem to be more phosphorylated in GlyLac medium, these phosphorylated Ccr4, Pan2, and Pan3 proteins might be required to maintain a proper homeostasis in low energy media.In[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34280615
PAN2 affects ASF1A
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PAN2 binds ASF1A.
2 | 3 14
ASF1A binds PAN2. 10 / 19
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"To gain further support of the in vivo interaction between ASF1A and USP52, protein fractionation experiments with FLAG-ASF1A affinity eluates were carried out."
29599486
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"These results support the observation that ASF1A is physically associated with USP52 in vivo and suggest that ASF1A interacts with USP52 in cytoplasm."
29599486
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"Collectively, these results indicate that ASF1A interacts with USP52 through the N-terminal region of ASF1A and the WD40 repeat domain of USP52."
29599486
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"In addition, the interaction of USP52 and ASF1A further promotes the assembly of chromatin and cell cycle progress [ 16 ]."
37328395
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"Corroborating with the finding that WD40 repeat domain is required for the physical association of USP52 with ASF1A, expression of USP52 lacking WD40 repeat domain (USP52/ΔWD40) did not affect the level of ubiquitinated ASF1A species (Supplementary Fig.  xref )."
29599486
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"In addition, the interaction of USP52 and ASF1A further promotes the assembly of chromatin and cell cycle progress [ 16 ]."
37328395
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"In vivo deubiquitination assays showed an evident decrease in the polyubiquitination level of all ASF1A mutants except for K129R (Fig.  xref and Supplementary Fig.  xref ), while the association of USP52 with all ASF1A mutants was comparable to that of USP52 with wild-type ASF1A (Supplementary Fig.  xref )."
29599486
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"Moreover, the reduction in ASF1A protein level associated with USP52 depletion was probably through a proteasome-mediated protein degradation mechanism, as the effect could be effectively blocked by a proteasome specific inhibitor, MG132 (Fig.  xref )."
29599486
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"Consistently, the physical association of USP52 with ASF1A was detected primarily in the S phase of the cell cycle (Fig.  xref )."
29599486
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"Collectively, these observations suggest that USP52-promoted ASF1A stabilization is potentially associated with breast carcinogenesis."
29599486
PAN2 activates ASF1A.
| 15
PAN2 activates ASF1A. 10 / 15
| 15
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"To corroborate the role of USP52 promoted ASF1A stabilization in chromatin replication, cellular extracts from cells used in MNase digestion assays were collected and analyzed by western blotting."
29599486
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"Remarkably, we also revealed that histone H3K56Ac levels were downregulated upon impairment of USP52 promoted ASF1A stabilization."
29599486
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"USP52 promoted ASF1A stabilization facilitates chromatin assembly and favors cell cycle progression."
29599486
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"Considering that ASF1A also plays an important role in replication independent chromatin assembly and chromatin disassembly during transcriptional activation XREF_BIBR, XREF_BIBR, XREF_BIBR, it is interesting to investigate whether USP52 promoted ASF1A stabilization plays a role in these processes."
29599486
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"Collectively, these results support the notion that USP52 promoted ASF1A stabilization confers cellular resistance of breast cancer cells to genotoxic insults."
29599486
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"In this study, we revealed that the expression level of USP52 and ASF1A is upregulated in breast cancer and positively correlates with each other, and, indeed, USP52 promoted ASF1A stabilization is required for breast cancer cells to combat with genotoxic insults."
29599486
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"Taken together, these data indicate that USP52 targets ASF1A and K129 for deubiquitination and USP52 is a bona fide deubiquitinase for ASF1A."
29599486
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"These results suggest that USP52 promotes chromatin assembly in an ASF1A dependent manner."
29599486
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"USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization."
29599486
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"These results favor the argument that USP52 promoted ASF1A stabilization regulates DNA synthesis coupled chromatin assembly through ASF1A mediated deposition of H3K56Ac."
29599486
PAN2 deubiquitinates ASF1A.
1 | 4
PAN2 deubiquitinates ASF1A. 5 / 5
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"Additionally, we find that <span class="match term0">USP52</span> is overexpressed in breast carcinomas, and its level of expression correlates with that of <span class="match term1">ASF1A</span>."
29599486
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"USP52 deubiquitinates ASF1A."
29599486
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"Nevertheless, our study identified that USP52 is a bona fide USP, and revealed that USP52 deubiquitinates and stabilizes histone chaperone ASF1A."
29599486
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"Interestingly, we demonstrate that USP52 is a bona fide ubiquitin specific protease, and USP52 promotes ASF1A deubiquitination and stabilization."
29599486
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"Since ASF1A is reported as a ubiquitinated protein 49, we then asked whether USP52 functions to deubiquitinate ASF1A."
29599486
PAN2 inhibits ASF1A.
| 1
PAN2 inhibits ASF1A. 1 / 1
| 1
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"Moreover, we reveal that impairment of USP52 promoted ASF1A stabilization results in growth arrest of breast cancer cells and sensitizes these cells to DNA damage."
29599486
PAN2 increases the amount of ASF1A.
| 1
Modified PAN2 increases the amount of ASF1A. 1 / 1
| 1
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"Next, we found overexpression of USP52 was able to restore the expression of ASF1A in USP52 deficient cells."
29599486
SFXN1 affects PAN2
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PAN2 binds SFXN1. 10 / 27
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"Peritoneal dissemination of cancer cells to the peritoneum, mesenterium, diaphragm, and others, was observed in a large proportion of the mice inoculated with TCC-Pan2 cells."
30747829
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"To test this, we pre-treated PK-8 and TCC-Pan2 cells with the mitochondrial-specific ROS scavenger Mito-TEMPO [ xref ] for 3 h prior to HSP70 inhibition with AP-4-139B. Interestingly, we found that pre-treatment of PDAC cells with Mito-TEMPO significantly suppressed the ability of AP-4-139B to induce AMPK phosphorylation at threonine 172 (Fig.  xref )."
38802657
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"To evaluate the potential for compensation of transferrin-mediated iron uptake to rescue proliferation, we tested TCC-Pan2 NCOA4 KD cells for rescue by holo-transferrin, demonstrating a partial rescue ( xref )."
35771492
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"Intriguingly, LCN2 levels were also significantly elevated in TCC-Pan2 NCOA4 KD proteomes (Supplementary Fig. S5E)."
35771492
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"After OI of TCC-Pan2 cells, peritoneal metastasis and ascites formation occurred in 66.6% of the host mice (Table xref )."
30747829
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"Therefore, we evaluated FPN expression by immunoblot (not detected in proteome) and demonstrated a decrease in expression in TCC-Pan2 and PANC-1 NCOA4 KD cells ( xref )."
35771492
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"The xenografted PCa models have been studied using colon cancer (HCT-116, LS174T, HT29, SW480, SW620, LoVo, RKO, Caco-2, KM12, MDST8, HUTU80) [ xref , xref , xref , xref , xref ], pancreatic cancer (Panc-1, TCC-Pan2, BxPC3, AsPC-1) [ xref , xref , xref ], gastric cancer (60As6, HSC-44PE, HSC-58, MKN45-P) [ xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref ], and ovarian cancer (OVCAR3, OVCAR4, OVCAR5, OVCAR8, CAOV3, OVSAHO, OV2944-HM-1, SKOV-3) [ xref , xref , xref , xref ] cell lines."
33669017
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"TCC-Pan2 cell line was characterized for growth rate, tumor markers, histology, and somatic mutations."
30747829
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"TCC-Pan2 cells were implanted orthotopically to produce PD."
30747829
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"TCC-Pan2 cells from these metastatic foci were expanded in vitro and then implanted orthotopically in mice."
30747829
ASF1A affects PAN2
2 | 6 14
ASF1A binds PAN2.
2 | 3 14
ASF1A binds PAN2. 10 / 19
2 | 3 14
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"To gain further support of the in vivo interaction between ASF1A and USP52, protein fractionation experiments with FLAG-ASF1A affinity eluates were carried out."
29599486
sparser
"These results support the observation that ASF1A is physically associated with USP52 in vivo and suggest that ASF1A interacts with USP52 in cytoplasm."
29599486
sparser
"Collectively, these results indicate that ASF1A interacts with USP52 through the N-terminal region of ASF1A and the WD40 repeat domain of USP52."
29599486
sparser
"In addition, the interaction of USP52 and ASF1A further promotes the assembly of chromatin and cell cycle progress [ 16 ]."
37328395
sparser
"Corroborating with the finding that WD40 repeat domain is required for the physical association of USP52 with ASF1A, expression of USP52 lacking WD40 repeat domain (USP52/ΔWD40) did not affect the level of ubiquitinated ASF1A species (Supplementary Fig.  xref )."
29599486
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"In addition, the interaction of USP52 and ASF1A further promotes the assembly of chromatin and cell cycle progress [ 16 ]."
37328395
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"In vivo deubiquitination assays showed an evident decrease in the polyubiquitination level of all ASF1A mutants except for K129R (Fig.  xref and Supplementary Fig.  xref ), while the association of USP52 with all ASF1A mutants was comparable to that of USP52 with wild-type ASF1A (Supplementary Fig.  xref )."
29599486
sparser
"Moreover, the reduction in ASF1A protein level associated with USP52 depletion was probably through a proteasome-mediated protein degradation mechanism, as the effect could be effectively blocked by a proteasome specific inhibitor, MG132 (Fig.  xref )."
29599486
sparser
"Consistently, the physical association of USP52 with ASF1A was detected primarily in the S phase of the cell cycle (Fig.  xref )."
29599486
sparser
"Collectively, these observations suggest that USP52-promoted ASF1A stabilization is potentially associated with breast carcinogenesis."
29599486
ASF1A activates PAN2.
| 3
ASF1A activates PAN2. 3 / 3
| 3
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"Indeed, USP52 deficiency impaired chromatin assembly and DNA replication as well as S-phase progression, the effect of which could be largely restored by ASF1A gain of function."
29599486
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"Taken together, these data indicate that USP52 targets ASF1A and K129 for deubiquitination and USP52 is a bona fide deubiquitinase for ASF1A."
29599486
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"Meanwhile, western blotting analysis revealed that the upregulation of H3K56Ac trigged by IR was disrupted upon USP52 depletion, the effect of which could be restored by ASF1A gain of function."
29599486
PAN2 is modified
2 | 18
PAN2 is phosphorylated. 10 / 15
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"We hypothesized that ATM-mediated phosphorylation of USP52 activates its DUB activity."
33097710
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"Because the interaction between CtIP and USP52 was not changed before or after IR treatment, it is possible that the phosphorylation of USP52 increases its catalytic capability but not the affinity toward CtIP."
33097710
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"Then we considered the possibility that Ccr4, Pan2, and Pan3 are phosphorylated in response to the change of carbon source."
34280615
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"To further analyze the role of USP52 phosphorylation in regulating DNA end resection and HR, we re-expressed WT USP52 and USP52 S1003A mutant in USP52-deficient cells to compare their biological functions."
33097710
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"In this experiment, the phosphorylation of Ccr4, Pan2, and Pan3 were assessed in vivo using the HA-tagged version of proteins and Phos-tag SDS-PAGE."
34280615
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"We further evaluated whether USP52 phosphorylation by ATM affects CHK1 and RPA2 phosphorylation and render cells resistant to cancer therapy."
33097710
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"As shown in Fig.  xref , CtIP ubiquitination level was significantly decreased in cells expressing WT USP52 but not the S1003A mutant after IR treatment, suggesting that USP52 phosphorylation is critical for deubiquitinating CtIP following IR exposure."
33097710
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"These results suggest that USP52 phosphorylation by ATM is important for its role in regulating DNA end resection and HR through regulating CtIP deubiquitination."
33097710
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"Indeed, we found that USP52 was phosphorylated at SQ/TQ motifs in response to IR, and this phosphorylation could be abolished by pretreating cells with an ATM inhibitor or treating cell lysates with phosphatase (Fig.  xref ), indicating that USP52 could be phosphorylated in an ATM-dependent manner following IR treatment."
33097710
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"As shown in Supplementary Fig.  xref , xref , reconstitution of USP52-deficient cells with WT USP52 but not USP52 S1003A rescued USP52 depletion-induced defects, including CHK1 and RPA2 phosphorylation and IR and PARPi response, suggesting that USP52 phosphorylation by ATM is important for proper DDR."
33097710
PAN2 is phosphorylated on S1003. 3 / 3
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"We next examined which SQ/TQ site of USP52 was phosphorylated and found that the S1003A but not S469A mutation mostly abolished the phosphorylation of USP52 after DNA damage (Fig.  xref and Supplementary Fig.  xref ), suggesting that USP52 is phosphorylated on Ser-1003 in an ATM-dependent manner following IR treatment."
33097710
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"These results suggest that phosphorylation of USP52 S1003 plays a vital role in regulating the DUB activity of USP52."
33097710
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"To further examine whether the phosphorylation of USP52 at S1003 regulates CtIP deubiquitination, we reconstituted WT or the S1003A mutants in USP52-deficient cells and examined the ubiquitination level of CtIP with or without IR treatment."
33097710
PAN2 is phosphorylated on S1189. 2 / 2
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PAN2 affects RBBP8
2 3 1 | 3 5
PAN2 binds RBBP8.
3 | 1 5
RBBP8 binds PAN2. 9 / 9
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33097710
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33097710
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"As shown in Supplementary Fig.  xref and Fig.  xref , WT USP52, but not the USP52 ΔWD40 truncate, successfully rescued DSB resection and HR in USP52-depleted cells, suggesting that the USP52–CtIP interaction is important for the role of USP52 in DSB resection and HR."
33097710
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"This further confirms the interaction between USP52 and CtIP in cells."
33097710
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"Interestingly, the interaction between USP52 and CtIP did not change with IR treatment (Supplementary Fig.  xref ), suggesting their interactions are not DNA damage inducible."
33097710
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"As shown in Fig.  xref , the N-terminal region (AA17–AA160) of CtIP and the WD40 domain of USP52 are indispensable for the interaction between CtIP and USP52."
33097710
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"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
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"Because the interaction between CtIP and USP52 was not changed before or after IR treatment, it is possible that the phosphorylation of USP52 increases its catalytic capability but not the affinity toward CtIP."
33097710
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No evidence text available
33097710
PAN2 deubiquitinates RBBP8.
1 1 | 2
PAN2 deubiquitinates RBBP8. 3 / 3
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"Here, we identify that USP52 directly interacts with and deubiquitinates CtIP, thereby promoting DNA end resection and HR. Mechanistically, USP52 removes the ubiquitination of CtIP to facilitate the phosphorylation and activation of CtIP at Thr-847. In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."
33097710
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"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
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"Mechanistically, <span class="match term0">USP52</span> removes the ubiquitination of <span class="match term1">CtIP</span> to facilitate the phosphorylation and activation of <span class="match term1">CtIP</span> at Thr-847"
33097710
PAN2 deubiquitinates RBBP8 on T847. 1 / 1
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"USP52 can directly deubiquitinate CtIP and facilitate its phosphorylation at Thr-847 [142]."
38702734
PAN2 activates RBBP8.
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PAN2 activates RBBP8. 1 / 1
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signor
"Here, we identify that USP52 directly interacts with and deubiquitinates CtIP, thereby promoting DNA end resection and HR. Mechanistically, USP52 removes the ubiquitination of CtIP to facilitate the phosphorylation and activation of CtIP at Thr-847. In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."
33097710
PABPC1 affects PAN2
5 2 | 5 2
PABPC1 binds PAN2.
5 2 | 2 1
PAN2 binds PABPC1. 9 / 9
5 1 | 2 1
reach
"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."
25084349
biogrid
No evidence text available
17785442
biogrid
No evidence text available
29395067
sparser
"Mangus et al. have shown that Pbp1 negatively regulates Pan2 deadenylase by disturbing the Pab1-Pan2 interaction, and that the cell extract from pbp1Δ single mutant in the stationary phase has stronger deadenylase activity than that in WT in vitro [ xref , xref ]."
28231297
biogrid
No evidence text available
31104843
hprd
No evidence text available
14583602
biogrid
No evidence text available
23398456
reach
"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."
25084349
biogrid
No evidence text available
14583602
PABPC1 binds PAN2 and PAN3. 1 / 1
1 |
hprd
No evidence text available
18056425
PABPC1 activates PAN2.
| 2 1
PABPC1 activates PAN2. 3 / 3
| 2 1
reach
"Because Pab1 stimulates Pan2 and interacts directly with Pan3 through its C-terminal region, an alternative interpretation could be that removal of the corresponding Pab1 domain inhibits deadenylation by preventing Pan2 action."
17766253
sparser
"Pab1 can recruit or activate the deadenylases Pan2-Pan3 and the Ccr4 subunit of the Ccr4-Not complex, which cooperate in shortening the pA tail, thought to be a prerequisite for degradation of the transcript ( xref , xref )."
38903079
reach
"Since Pab1 promotes Pan2 activity, one model is that this deadenylation reflects Pab1 bound to the first ~ 65 residues of the A tail, but the 3 ' most region is exposed and thereby rapidly deadenylated by Pan2."
22785621
PABPC1 inhibits PAN2.
| 1
PABPC1 inhibits PAN2. 1 / 1
| 1
reach
"Because Pab1 stimulates Pan2 and interacts directly with Pan3 through its C-terminal region, an alternative interpretation could be that removal of the corresponding Pab1 domain inhibits deadenylation by preventing Pan2 action."
17766253
PAN2 affects HIF1A
| 1 9
PAN2 activates HIF1A.
| 1 6
PAN2 activates HIF1A. 7 / 7
| 1 6
reach
"To rule out any effects of USP52 on HIF1A translation, we performed polysome profiling on U2OS cells treated with either NT or USP52 siRNA."
23398456
reach
"During a screening of mediators for HIF1A mediated hypoxic response, USP52 and PAN2, a component of P-bodies, was found to promote the stability of HIF1A mRNA in 3 ' UTR dependent manner, as documented with the use of knockdown experiments.156 However, the direct binding of this protein to AREs was not studied, and interactions with de facto RPBs, such as TTP, can possibly happen in P-bodies."
27251431
reach
"To obtain insight into the observed USP52 mediated stabilization of HIF1A mRNA, we performed proteomic analysis of USP52 immunoprecipitates to identify new USP52 associated proteins."
23398456
reach
"Disrupting USP52 containing P-bodies by GW182 depletion reduces HIF1A mRNA."
23398456
reach
"To investigate further the role of USP52in the HIF1A mediated hypoxic response, U2OS cells were treated with individual USP52 siRNA duplexes 1 and 3 and exposed to hypoxia."
23398456
eidos
"USP52 increases HIF-1alpha protein levels through stabilizing HIF-1alpha mRNA instead of affecting HIF-1alpha ubiquitination [ 69,84 ] ."
33466790
reach
"This demonstrates that USP52 knockdown specifically reduces HIF1A mRNA abundance, and supports the previous observation that decreased HIF1A mRNA is associated with up-regulation of HIF2A [XREF_BIBR]."
23398456
PAN2 inhibits HIF1A.
| 2
PAN2 inhibits HIF1A. 2 / 3
| 2
reach
"Depletion of USP52 reduced HIF1A mRNA and protein levels and resulted in reduced expression of HIF1A regulated hypoxic targets due to a 3 '-UTR (untranslated region)-dependent poly (A)-tail-length-independent destabilization in HIF1A mRNA."
23398456
reach
"To address whether USP52 negatively regulates HIF1A protein through interactions with the VHL complex, U2OS cells were treated with MLN4924 [XREF_BIBR] to inhibit the NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8)-interacting enzyme and block VHL activity."
23398456
PAN2 increases the amount of HIF1A.
| 1
PAN2 increases the amount of HIF1A. 1 / 3
| 1
reach
"USP52 increases HIF-1alpha protein levels through stabilizing HIF-1alpha mRNA instead of affecting HIF-1alpha ubiquitination [XREF_BIBR, XREF_BIBR]."
33466790
CNOT7 affects PAN2
| 3 8
CNOT7 binds PAN2.
| 2 8
PAN3 binds CNOT7, PAN2, and ccr4. 5 / 5
| 5
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
CNOT7 binds PAN2. 4 / 4
| 2 2
sparser
"However, when HA-Pan2 was ectopically expressed alone ( xref ), endogenous Caf1, but not PABP, was coprecipitated with HA-Pan2, indicating a specific interaction between Pan2 and Caf1, either directly or indirectly."
18625844
reach
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly (A) nucleases, respectively, their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Therefore, Pan2–Pan3 and Ccr4–Caf1 complexes may communicate with each other in vivo via the interaction between Pan2 and Caf1."
18625844
reach
"Therefore, Pan2-Pan3 and Ccr4-Caf1 complexes may communicate with each other in vivo via the interaction between Pan2 and Caf1."
18625844
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
CNOT7 inhibits PAN2.
| 1
CNOT7 inhibits PAN2. 1 / 1
| 1
reach
"PAN2 depletion, like CAF1 depletion, did not cause an increase in steady-state levels of these mRNAs (XREF_FIG and E, and data not shown)."
19596809
PAN2 affects PABPC1
5 2 | 2 1
PAN2 binds PABPC1. 9 / 9
5 1 | 2 1
reach
"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."
25084349
biogrid
No evidence text available
17785442
biogrid
No evidence text available
29395067
sparser
"Mangus et al. have shown that Pbp1 negatively regulates Pan2 deadenylase by disturbing the Pab1-Pan2 interaction, and that the cell extract from pbp1Δ single mutant in the stationary phase has stronger deadenylase activity than that in WT in vitro [ xref , xref ]."
28231297
biogrid
No evidence text available
31104843
hprd
No evidence text available
14583602
biogrid
No evidence text available
23398456
reach
"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."
25084349
biogrid
No evidence text available
14583602
PABPC1 binds PAN2 and PAN3. 1 / 1
1 |
hprd
No evidence text available
18056425
PAN2 affects CNOT7
| 2 8
PAN3 binds CNOT7, PAN2, and ccr4. 5 / 5
| 5
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
CNOT7 binds PAN2. 4 / 4
| 2 2
sparser
"However, when HA-Pan2 was ectopically expressed alone ( xref ), endogenous Caf1, but not PABP, was coprecipitated with HA-Pan2, indicating a specific interaction between Pan2 and Caf1, either directly or indirectly."
18625844
reach
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly (A) nucleases, respectively, their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Therefore, Pan2–Pan3 and Ccr4–Caf1 complexes may communicate with each other in vivo via the interaction between Pan2 and Caf1."
18625844
reach
"Therefore, Pan2-Pan3 and Ccr4-Caf1 complexes may communicate with each other in vivo via the interaction between Pan2 and Caf1."
18625844
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
SLC7A11 affects PAN2
| 9
PAN2 binds SLC7A11. 9 / 9
| 9
sparser
"All the aforementioned findings regarding the regulation and underlying mechanism of the USP52‐xCT axis prompted us to further investigate whether USP52 is linked to BLCA progression and prognosis in clinical samples."
39392373
sparser
"Altogether, these findings indicate that USP52 interacts with xCT and promotes its stability in an enzyme‐dependent manner."
39392373
sparser
"Mechanistically, USP52 interacts with xCT and enzymatically cleaves the K48‐conjugated ubiquitin chains at K4 and K12, enhancing its protein stability."
39392373
sparser
"These findings elucidate the role of the USP52‐xCT axis in BLCA and highlight the therapeutic potential of targeting USP52 and ferroptosis inducers in BLCA."
39392373
sparser
"USP52 Physically Interacts with xCT and Maintains Its Stability."
39392373
sparser
"Plasmids encoding Myc‐tagged USP52 and Flag‐tagged xCT were transfected into HEK293T cells, and co‐IP assays revealed an exogenous interaction between USP52 and xCT ( Figure   xref )."
39392373
sparser
"To better understand the underlying mechanism of the USP52‐xCT axis in the regulation of BLCA progression, we further performed a series of coimmunoprecipitation (co‐IP) analyses."
39392373
sparser
"Mechanistically, USP52 physically associated with xCT through its WD40 domain, leading to xCT K48‐conjugated deubiquitination at K4 and K12, which in turn promoted xCT protein stability."
39392373
sparser
"Similarly, endogenous USP52 efficiently interacted with xCT in 5637 and T24 cells (Figure  xref )."
39392373
RBBP8 affects PAN2
3 | 1 5
RBBP8 binds PAN2. 9 / 9
3 | 1 5
biogrid
No evidence text available
33097710
biogrid
No evidence text available
33097710
sparser
"As shown in Supplementary Fig.  xref and Fig.  xref , WT USP52, but not the USP52 ΔWD40 truncate, successfully rescued DSB resection and HR in USP52-depleted cells, suggesting that the USP52–CtIP interaction is important for the role of USP52 in DSB resection and HR."
33097710
sparser
"This further confirms the interaction between USP52 and CtIP in cells."
33097710
sparser
"Interestingly, the interaction between USP52 and CtIP did not change with IR treatment (Supplementary Fig.  xref ), suggesting their interactions are not DNA damage inducible."
33097710
sparser
"As shown in Fig.  xref , the N-terminal region (AA17–AA160) of CtIP and the WD40 domain of USP52 are indispensable for the interaction between CtIP and USP52."
33097710
reach
"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
sparser
"Because the interaction between CtIP and USP52 was not changed before or after IR treatment, it is possible that the phosphorylation of USP52 increases its catalytic capability but not the affinity toward CtIP."
33097710
biogrid
No evidence text available
33097710
PAN2 affects SLC7A11
| 9
PAN2 binds SLC7A11. 9 / 9
| 9
sparser
"All the aforementioned findings regarding the regulation and underlying mechanism of the USP52‐xCT axis prompted us to further investigate whether USP52 is linked to BLCA progression and prognosis in clinical samples."
39392373
sparser
"Altogether, these findings indicate that USP52 interacts with xCT and promotes its stability in an enzyme‐dependent manner."
39392373
sparser
"Mechanistically, USP52 interacts with xCT and enzymatically cleaves the K48‐conjugated ubiquitin chains at K4 and K12, enhancing its protein stability."
39392373
sparser
"These findings elucidate the role of the USP52‐xCT axis in BLCA and highlight the therapeutic potential of targeting USP52 and ferroptosis inducers in BLCA."
39392373
sparser
"USP52 Physically Interacts with xCT and Maintains Its Stability."
39392373
sparser
"Plasmids encoding Myc‐tagged USP52 and Flag‐tagged xCT were transfected into HEK293T cells, and co‐IP assays revealed an exogenous interaction between USP52 and xCT ( Figure   xref )."
39392373
sparser
"To better understand the underlying mechanism of the USP52‐xCT axis in the regulation of BLCA progression, we further performed a series of coimmunoprecipitation (co‐IP) analyses."
39392373
sparser
"Mechanistically, USP52 physically associated with xCT through its WD40 domain, leading to xCT K48‐conjugated deubiquitination at K4 and K12, which in turn promoted xCT protein stability."
39392373
sparser
"Similarly, endogenous USP52 efficiently interacted with xCT in 5637 and T24 cells (Figure  xref )."
39392373
Ccr4 affects PAN2
| 8
PAN3 binds CNOT7, PAN2, and ccr4. 5 / 5
| 5
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
PAN2 binds exonuclease, BLNK, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
TFDP1 affects PAN2
8 |
TFDP1 decreases the amount of PAN2. 8 / 8
8 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
PAN2 affects ccr4
| 8
PAN3 binds CNOT7, PAN2, and ccr4. 5 / 5
| 5
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
PAN2 binds exonuclease, BLNK, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PABP affects PAN2
| 6 2
PABP binds PAN2.
| 2 2
PAN2 binds PABP. 4 / 4
| 2 2
reach
"The modest amount of endogenous PABP in the precipitate (XREF_FIG) suggests an indirect association between HA-Pan2 and PABP, presumably mediated via Pan3-V5, as HA-Pan2 alone did not pull down PABP (XREF_FIG)."
18625844
reach
"We have previously reported that mRNA decay is triggered by translation termination and proposed a model for the initiation of mRNA decay: after translation termination, the termination factors eRF1–eRF3 dissociate from PABP bound to the 3′ poly(A) tail, and in turn, Pan2–Pan3 and Caf1–Ccr4 deadenylases associate with PABP, which leads to the activation of the deadenylases and shortening of the poly(A) tail (6,7)."
30395302
sparser
"To study the contribution of each Pan3 domain to the interactions of Pan3 isoforms with PABP and Pan2, we created a series of domain truncation mutants of both Pan3 isoforms ( xref A) for co-IP experiments using both NIH3T3 and BEAS-2B cells."
28559491
sparser
"As Pan3 is a PABP-interacting protein ( xref ; xref ; xref ) that regulates Pan2 activity ( xref ; xref ; xref ; xref ; xref ; xref ; xref ; xref ), we conducted co-IP experiments to analyze the two Pan3 isoforms’ ability to interact with PABP or Pan2."
28559491
PABP activates PAN2.
| 4
PABP activates PAN2. 3 / 3
| 3
reach
"PABP regulates deadenylation of mRNPs by binding Pan3 and stimulating Pan2 nuclease activity and interacting with GW182 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR] through a C-terminal motif that is removed by both viral proteinases."
26610553
reach
"To initiate deadenylation, the two PAN3 subunits recognize two poly(A)-bound PABP molecules allowing the RNase active site of PAN2 to remove the 3′ terminal A residues of mRNA poly(A) tail [ 6 , 7 ]."
33775689
reach
"PAN2 is activated by PABP in vitro XREF_BIBR."
25968143
PABP bound to PAN3 activates PAN2. 1 / 1
| 1
reach
"For example, PABP 's interaction with Pan3 enhances Pan2 nuclease activity."
23224971
ATM affects PAN2
1 1 | 6
ATM phosphorylates PAN2. 4 / 4
| 4
sparser
"As shown in Supplementary Fig.  xref , xref , reconstitution of USP52-deficient cells with WT USP52 but not USP52 S1003A rescued USP52 depletion-induced defects, including CHK1 and RPA2 phosphorylation and IR and PARPi response, suggesting that USP52 phosphorylation by ATM is important for proper DDR."
33097710
sparser
"Phosphorylation of USP52 by ATM under IR treatment."
33097710
sparser
"These results suggest that USP52 phosphorylation by ATM is important for its role in regulating DNA end resection and HR through regulating CtIP deubiquitination."
33097710
sparser
"We further evaluated whether USP52 phosphorylation by ATM affects CHK1 and RPA2 phosphorylation and render cells resistant to cancer therapy."
33097710
ATM phosphorylates PAN2 on S1003. 4 / 4
1 1 | 2
biopax:phosphositeplus
No evidence text available
sparser
"In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."
33097710
sparser
"Our results suggest that the phosphorylation of USP52 on Ser-1003 by ATM increases the activity of USP52 to deubiquitinate CtIP and promote DNA end resection and HR repair."
33097710
signor
"Here, we identify that USP52 directly interacts with and deubiquitinates CtIP, thereby promoting DNA end resection and HR. Mechanistically, USP52 removes the ubiquitination of CtIP to facilitate the phosphorylation and activation of CtIP at Thr-847. In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."
33097710
Ccr4 affects PAN3
| 7
PAN3 binds CNOT7, PAN2, and ccr4. 5 / 5
| 5
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN2 affects MYC
| 7
PAN2 binds MYC. 7 / 7
| 7
sparser
"T-REx-HeLa cells were co-transfected with pCMV-2 × TO-5 × Myc-Pan2 and a plasmid expressing 5 × Flag-β-globin reporter mRNA."
38869059
sparser
"The expression of 5 × Myc-Pan2, PAT shortening of the reporter mRNA and SG formation were monitored ( xref )."
38869059
sparser
"Time-dependent induction of 5 × Myc-Pan2 and shortening of the reporter mRNA PAT were observed after tetracycline treatment ( xref )."
38869059
sparser
"T-REx HeLa cells were co-transfected with a plasmid expressing c-myc mRNA, a reference plasmid expressing 5 × Flag-GST-CAT, and either pCMV-5 × Myc-Pan2 D1083A, pCMV-5 × Myc-Caf1 D161A or, as a contro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25446091
sparser
"We expressed 5 × Myc-Pan2, 5 × Myc-Pan2 D1083A mutant, 5 × Myc-Caf1, or 5 × Myc-Caf1 D161 mutant and analyzed PB formation by indirect immunofluorescence using the PB marker protein DDX6."
38869059
sparser
"Then, we individually mutated these lysine (K) residues to arginine (R) residues and coexpressed them with Myc‐USP52."
39392373
sparser
"HeLa cells were co-transfected with plasmids expressing Flag-β-globin mRNA and either 5 × Myc-Pan2 or 5 × Myc-Pan2 D1083A, which has no deadenylase activity and acts as dominant-negative to the Pan2 deadenylase activity ( xref ), and the mRNA was analyzed by northern blotting."
38869059
E2F1 affects PAN2
7 |
E2F1 decreases the amount of PAN2. 7 / 7
7 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Ccr4 affects CNOT7
| 6
PAN3 binds CNOT7, PAN2, and ccr4. 5 / 5
| 5
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
Guanosines affects PAN2
| 5
Guanosines inhibits PAN2. 5 / 5
| 5
reach
"We found that 3′ guanosines can strongly inhibit S. cerevisiae and H. sapiens Pan2–Pan3 and S. pombe Ccr4–Not in a fully reconstituted in vitro system (Fig. 1b-c, Fig. 2b)."
31110294
reach
"On the other hand, guanosines or dihydrouracils strongly inhibit Pan2 and Caf1 as they are unable to adopt the stacked, helical structure of poly(A) RNA."
31110294
reach
"3' guanosines inhibit the Pan2 exonuclease."
31110294
reach
"To understand why guanosines inhibit Pan2, we soaked AAGGA or AAGGAA RNAs into Pan2 crystals, which diffracted to 3."
31110294
reach
"Together, these data suggest that guanosines disrupt the stacked, helical conformation of poly(A) in the Pan2 active site."
31110294
Pan3L affects PAN2
| 1 4
Pan3L binds PAN2.
| 3
Pan3L binds PAN2. 3 / 3
| 3
sparser
"We propose that the first phase of deadenylation, involving differential actions of Pan2–Pan3S and Pan2–Pan3L, represents a previously unsuspected step of mRNA “maturation” in the cytoplasm, with the potential to modulate critical mRNP remodeling and influence the cytoplasmic fate of mRNA."
28559491
sparser
"Given that Pan 2 and Pan3L are both shuttling proteins ( xref ) but Pan3S is not (), we propose that Pan3L may associate with Pan2 in the nucleus and inhibit Pan2 deadenylase activity."
28559491
sparser
"As several recent structural and in vitro studies ( xref ; xref ; xref ; xref ) showed that Pan3 is dimeric when complexed with Pan2, Pan3S may associate with Pan2–Pan3L complex via dimerization with Pan3L in the cytoplasm."
28559491
Pan3L inhibits PAN2.
| 1 1
Pan3L inhibits PAN2. 2 / 2
| 1 1
reach
"Pan2 deadenylase activity is enhanced by Pan3S but suppressed by Pan3L."
28559491
sparser
"After the poly(A) tail is shortened to 110–150 nt by Pan2, a conformational change of the complex may occur to allow Pan3L to inactivate Pan2 and conclude the first phase of deadenylation ()."
28559491
reach
"Consequently, their research demonstrated that USP52 facilitates anti-silencing function 1A histone chaperone (ASF1A) deubiquitination and stabilisation, thereby supporting chromatin assembly and promoting cell cycle progression (Yang et al., 2018)."
38455765
reach
"We reveal that USP52 promotes chromatin assembly through stabilizing ASF1A, and point a role of USP52 in breast carcinogenesis and cellular resistance of breast cancer cells to DNA damage."
29599486
reach
"USP52 promotes chromatin assembly through stabilizing ASF1A."
29599486
reach
"These results suggest that USP52 promotes chromatin assembly in an ASF1A dependent manner."
29599486
reach
"USP52 promoted ASF1A stabilization facilitates chromatin assembly and favors cell cycle progression."
29599486
CNOT7 affects PAN2, PAN3, and ccr4
| 5
PAN3 binds CNOT7, PAN2, and ccr4. 5 / 5
| 5
sparser
"The notion that the Pan2–Pan3 and Ccr4–Caf1 complexes can associate with each other was further confirmed by the results showing that Pan3-V5, endogenous Caf1, and a modest amount of endogenous PABP were coprecipitated with HA-Pan2 by an anti-HA antibody when HA-Pan2 and Pan3-V5 were coexpressed ( xref )."
18625844
sparser
"Since ARE/ARE-BP complexes have not yet been reported to directly interact with either the Pan2-Pan3 or Ccr4-Caf1 complex, one possibility is that the binding of ARE-BPs to AREs may interfere with the interaction between the 5′ cap/eIF4F complex and the 3′ poly(A)/PABP complex, thus preventing the formation of a closed-loop structure ( xref )."
21957004
sparser
"Although Pan3 and Caf1 associate with Pan2 and Ccr4 poly(A) nucleases, respectively ( xref ; xref ; xref ; xref ; xref ), their in vivo roles in mammalian mRNA turnover remain unclear."
18625844
sparser
"Pan2–Pan3 and Ccr4–Caf1 complexes can interact with each other in vivo."
18625844
sparser
"Additionally, Pan2-Pan3 can form a super complex with Ccr4-Caf1, which provides an opportunity to coordinate the two phases of deadenylation [ xref ]."
21957004
Valproic acid affects PAN2
4 |
Valproic acid decreases the amount of PAN2. 4 / 4
4 |
ctd
No evidence text available
26272509
ctd
No evidence text available
23179753
ctd
No evidence text available
27188386
ctd
No evidence text available
29154799
Guanosine affects PAN2
| 1 1 2
Guanosine inhibits PAN2. 4 / 4
| 1 1 2
eidos
"Caf1 shows strict specificity for poly ( A ) and is inhibited by all non-A nucleotides , whereas Pan2 is substantially inhibited only by guanosines at the end of a poly ( A ) tail ( Fig. 3A , B ) ."
32295929
sparser
"Caf1 shows strict specificity for poly(A) and is inhibited by all non-A nucleotides, whereas Pan2 is substantially inhibited only by guanosines at the end of a poly(A) tail ( xref )."
32295929
sparser
"To understand why guanosines inhibit Pan2, we soaked AAGGA or AAGGAA RNAs into Pan2 UCH-Exo crystals, which diffracted to 3.3 Å resolution ( xref )."
31110294
reach
"Strikingly, this two-color deadenylation assay showed that one guanosine was sufficient to inhibit Pan2."
31110294
reach
"Pbp1 negatively regulates Pan2 activity in the absence of Ccr4 in the stationary phase."
28231297
reach
"If Pan2 activity is inhibited by Pbp1, the LRG1 poly (A) tail length in the ccr4Delta pbp1Delta pan2Delta triple mutant would be longer than that in the ccr4Delta pbp1Delta double mutant in the stationary phase."
28231297
sparser
"Further analysis should be needed to elucidate the physiological role of Pan2 inhibition by Pbp1 in the stationary phase."
28231297
reach
"Consistently, we found that the shortening of the LRG1 poly (A) tail length in the ccr4Delta pbp1Delta mutant required Pan2 deadenylase in vivo, and that Pbp1 inhibited Pan2 activity only in the stationary phase but not in the log phase."
28231297
Pan3S affects PAN2
| 1 3
Pan3S binds PAN2.
| 2
Pan3S binds PAN2. 2 / 2
| 2
sparser
"On the other hand, knocking down Pan3L reduced the overall intensity of both peaks 1 and 2 ( xref E, cf. lanes 1 and 4), consistent with the idea that Pan2–Pan3S complex may digest the poly(A) tails all the way through to increase overall deadenylation."
28559491
sparser
"We propose that the first phase of deadenylation, involving differential actions of Pan2–Pan3S and Pan2–Pan3L, represents a previously unsuspected step of mRNA “maturation” in the cytoplasm, with the potential to modulate critical mRNP remodeling and influence the cytoplasmic fate of mRNA."
28559491
Pan3S activates PAN2.
| 1 1
Pan3S activates PAN2. 2 / 2
| 1 1
reach
"Pan2 deadenylase activity is enhanced by Pan3S but suppressed by Pan3L."
28559491
sparser
"When a conformation of the complex allows Pan3S to activate Pan2, deadenylation of the mRNA is enhanced ()."
28559491
PAN2 inhibits cell population proliferation. 4 / 4
| 4
reach
"This study demonstrates that USP52 inhibits cancer cell proliferation through downregulation of cyclin D1 as well as AKT/mTOR signaling pathway inhibition."
34533198
reach
"USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer."
34533198
reach
"However, the simultaneous elimination of Pan2 and Ccr4 strongly impairs yeast cell proliferation, suggesting that these proteins have overlapping deadenylase activities [25] ."
23545199
reach
"In a similar vein, Zhu et al. demonstrated that USP52 stabilizes PTEN, downregulates cyclin D1, and inhibits the AKT/mTOR pathway, thereby suppressing cancer cell proliferation (41)."
39697746
PAN2 affects PABP
| 2 2
PAN2 binds PABP. 4 / 4
| 2 2
reach
"The modest amount of endogenous PABP in the precipitate (XREF_FIG) suggests an indirect association between HA-Pan2 and PABP, presumably mediated via Pan3-V5, as HA-Pan2 alone did not pull down PABP (XREF_FIG)."
18625844
reach
"We have previously reported that mRNA decay is triggered by translation termination and proposed a model for the initiation of mRNA decay: after translation termination, the termination factors eRF1–eRF3 dissociate from PABP bound to the 3′ poly(A) tail, and in turn, Pan2–Pan3 and Caf1–Ccr4 deadenylases associate with PABP, which leads to the activation of the deadenylases and shortening of the poly(A) tail (6,7)."
30395302
sparser
"To study the contribution of each Pan3 domain to the interactions of Pan3 isoforms with PABP and Pan2, we created a series of domain truncation mutants of both Pan3 isoforms ( xref A) for co-IP experiments using both NIH3T3 and BEAS-2B cells."
28559491
sparser
"As Pan3 is a PABP-interacting protein ( xref ; xref ; xref ) that regulates Pan2 activity ( xref ; xref ; xref ; xref ; xref ; xref ; xref ; xref ), we conducted co-IP experiments to analyze the two Pan3 isoforms’ ability to interact with PABP or Pan2."
28559491
FUS affects PAN2
| 4
FUS inhibits PAN2.
| 3
FUS inhibits PAN2. 3 / 3
| 3
reach
"The authors have shown FUS to be normally present in a complex with three 3′-end processing factors (CPSF6, PAN2, PABPC1); while FUS normally sequesters PAN2, and prevents it from deadenylating Gria1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31132467
reach
"These data suggest that FUS might sequester PAN2 on the PABP from attacking the poly (A) tail."
25968143
reach
"These data suggest that FUS sequesters PAN2 on PABPC1 and prevents it from deadenylating the poly (A) tail of the bound mRNA (XREF_SUPPLEMENTARY)."
25968143
FUS binds PAN2.
| 1
PAN2 binds FUS. 1 / 1
| 1
reach
"Moreover, CPSF6 and PAN2 interacted with FUS both in the presence and absence of RNase A, indicating that they form an RNA independent protein complex (XREF_FIG)."
25968143
Rep affects PAN2
3 |
Rep binds PAN2. 3 / 3
3 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
Bisphenol A affects PAN2
3 |
Bisphenol A decreases the amount of PAN2.
2 |
Bisphenol A decreases the amount of PAN2. 2 / 2
2 |
ctd
No evidence text available
30816183
ctd
No evidence text available
25181051
Bisphenol A increases the amount of PAN2.
1 |
Bisphenol A increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
29165653
ZFP36 affects PAN2
3 |
ZFP36 binds PAN2. 3 / 3
3 |
biogrid
No evidence text available
21078877
biogrid
No evidence text available
21078877
biogrid
No evidence text available
29395067
TNRC6C affects PAN2
3 |
TNRC6C binds PAN2. 3 / 3
3 |
biogrid
No evidence text available
21981923
biogrid
No evidence text available
29395067
biogrid
No evidence text available
21984184
PAN2 affects rep
3 |
Rep binds PAN2. 3 / 3
3 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
PAN2 affects cell cycle
| 3
PAN2 activates cell cycle. 2 / 2
| 2
reach
"Consequently, their research demonstrated that USP52 facilitates anti-silencing function 1A histone chaperone (ASF1A) deubiquitination and stabilisation, thereby supporting chromatin assembly and promoting cell cycle progression (Yang et al., 2018)."
38455765
reach
"USP52 promoted ASF1A stabilization facilitates chromatin assembly and favors cell cycle progression."
29599486
PAN2 bound to ASF1A activates cell cycle. 1 / 1
| 1
reach
"In addition, the interaction of USP52 and ASF1A further promotes the assembly of chromatin and cell cycle progress [ 16 ]."
37328395
PAN2 affects ZFP36
3 |
ZFP36 binds PAN2. 3 / 3
3 |
biogrid
No evidence text available
21078877
biogrid
No evidence text available
21078877
biogrid
No evidence text available
29395067
PAN2 affects TNRC6C
3 |
TNRC6C binds PAN2. 3 / 3
3 |
biogrid
No evidence text available
21981923
biogrid
No evidence text available
29395067
biogrid
No evidence text available
21984184
PAN2 affects Pan3L
| 3
Pan3L binds PAN2. 3 / 3
| 3
sparser
"We propose that the first phase of deadenylation, involving differential actions of Pan2–Pan3S and Pan2–Pan3L, represents a previously unsuspected step of mRNA “maturation” in the cytoplasm, with the potential to modulate critical mRNP remodeling and influence the cytoplasmic fate of mRNA."
28559491
sparser
"Given that Pan 2 and Pan3L are both shuttling proteins ( xref ) but Pan3S is not (), we propose that Pan3L may associate with Pan2 in the nucleus and inhibit Pan2 deadenylase activity."
28559491
sparser
"As several recent structural and in vitro studies ( xref ; xref ; xref ; xref ) showed that Pan3 is dimeric when complexed with Pan2, Pan3S may associate with Pan2–Pan3L complex via dimerization with Pan3L in the cytoplasm."
28559491
PAN2 affects PAB1
3 |
PAN2 binds PAB1. 3 / 3
3 |
biogrid
No evidence text available
16429126
biogrid
No evidence text available
37968396
biogrid
No evidence text available
31104843
PAN2 affects NFkappaB
| 3
PAN2 inhibits NFkappaB. 2 / 2
| 2
reach
"When expressed in HEK293 cells, PAN2 suppressed NF-kappaB induction by the cytokines tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta), suggesting that this protein operates at a point of convergence in these two cytokine signaling pathways."
12093792
reach
"PAN2 also suppressed NF-kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in the TNF or IL-1 receptor signal transduction, including TRAF2, TRAF6, RIP, IRAK2, and NF-kappaB-inducing kinase as well as the IkappaB kinases IKKalpha and IKKbeta."
12093792
PAN2 bound to CHUK inhibits NFkappaB. 1 / 1
| 1
reach
"On the other hand, PAN2 binds IKKalpha to reduce tumor necrosis factor (TNF)-alpha and IL-1beta-related NF-kappaB activation."
29904414
PAN2 affects MARF1
1 | 1 1
PAN2 binds MARF1. 2 / 2
1 | 1
biogrid
No evidence text available
27173435
reach
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2-Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1."
30279526
MARF1 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
30279526
PAB1 affects PAN2
3 |
PAN2 binds PAB1. 3 / 3
3 |
biogrid
No evidence text available
16429126
biogrid
No evidence text available
37968396
biogrid
No evidence text available
31104843
MARF1 affects PAN2
1 | 1 1
PAN2 binds MARF1. 2 / 2
1 | 1
biogrid
No evidence text available
27173435
reach
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2-Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1."
30279526
MARF1 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
30279526
Structure affects PAN2
| 2
Structure activates PAN2. 2 / 2
| 2
eidos
"Our biochemical , biophysical , and structural investigations suggest that poly ( A ) forms an intrinsic base-stacked , single-stranded helical conformation that is recognized by Pan2 , and that disruption of this structure inhibits both Pan2 and Caf1 ."
32295929
eidos
"Together , our data show that the intrinsic single-stranded helix of poly ( A ) is exploited by Pan2 for specificity and recognition , and that disruption of this structure is sufficient to inhibit Pan2 ( Fig. 6A ) ."
32295929
Pirinixic acid affects PAN2
2 |
Pirinixic acid increases the amount of PAN2.
1 |
Pirinixic acid increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid activates PAN2.
1 |
Pirinixic acid activates PAN2. 1 / 1
1 |
ctd
No evidence text available
19710929
Phenylmercury acetate decreases the amount of PAN2. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Ozone affects PAN2
2 |
Ozone increases the amount of PAN2.
1 |
Ozone increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
32699268
Ozone decreases the amount of PAN2.
1 |
Ozone decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
32845096
Exonuclease affects ccr4
| 2
PAN2 binds exonuclease, BLNK, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
Acrolein affects PAN2
2 |
Acrolein increases the amount of PAN2.
1 |
Acrolein increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
32699268
Acrolein decreases the amount of PAN2.
1 |
Acrolein decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
32845096
ZEB1 affects PAN2
2 |
PAN2 binds ZEB1. 2 / 2
2 |
biogrid
No evidence text available
29119051
biogrid
No evidence text available
29119051
YTHDF3 affects PAN2
1 | 1
YTHDF3 binds PAN2.
1 |
YTHDF3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
29395067
YTHDF3 activates PAN2.
| 1
YTHDF3 activates PAN2. 1 / 1
| 1
reach
"For example, YTHDF3 enhances mRNA clearance of somatic genes like Tead2 and Tgfb1 by recruiting the PAN2‐PAN3 deadenylase complex."
38811341
TFDP2 affects PAN2
2 |
TFDP2 decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
STAT5B affects PAN2
2 |
STAT5B decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
RELA affects PAN2
2 |
RELA decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
RB1 affects PAN2
2 |
RB1 decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
PUF3 affects PAN2
| 1 1
PAN2 binds PUF3. 2 / 2
| 1 1
reach
"An interaction between Pan2 and Puf3 could not be detected, suggesting that Puf3 affects the structure of the mRNA and the poly(A) tail-binding protein Pab1, thereby exposing the poly(A) tail to deade[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21115348
sparser
"An interaction between Pan2 and Puf3 could not be detected, suggesting that Puf3 affects the structure of the mRNA and the poly(A) tail-binding protein Pab1, thereby exposing the poly(A) tail to deade[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21115348
PLEC affects PAN2
2 |
PAN2 binds PLEC. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23398456
PAN2
1 | 1
PAN2 translocates.
| 1
PAN2 translocates to the contact site. 1 / 1
| 1
reach
"We find no evidence that PAN2 recruits PAN1 to the GMC contact site via a direct or indirect physical interaction, but PAN2 interacts with itself."
23175742
PAN2 binds.
1 |
PAN2 binds PAN2 bound to PAN3. 1 / 1
1 |
signor
"There are two major deadenylase complexes, Ccr4-Not and Pan2-Pan3, which shorten the 3′ poly(A) tail of mRNA and are conserved from yeast to human.The Ccr4-Not complex has two catalytic subunits including the Ccr4 (Carbon catabolite repressor 4) and Pop2 (PGK promoter directed overproduction). The Pan2-Pan3 complex comprises the catalytic subunit Pan2, a member of the RNase D family, and the regulatory subunit Pan3. Degradation of mRNA begins with either shortening of the poly(A) tail by deadenylases or removal of 5′ cap structure by the decapping enzyme Dcp1-Dcp2."
34280615
PAN2 affects stomatal closure
| 2
PAN2 activates stomatal closure. 2 / 2
| 2
reach
"PAN2 acts downstream of Ca 2+ in maize to promote stomatal closure."
37936339
reach
"Stomatal closure in maize is mediated by subsidiary cells and the PAN2 receptor."
37936339
PAN2 affects exonuclease
| 2
PAN2 binds exonuclease, BLNK, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN2 affects ZEB1
2 |
PAN2 binds ZEB1. 2 / 2
2 |
biogrid
No evidence text available
29119051
biogrid
No evidence text available
29119051
PAN2 affects Pan3S
| 2
Pan3S binds PAN2. 2 / 2
| 2
sparser
"On the other hand, knocking down Pan3L reduced the overall intensity of both peaks 1 and 2 ( xref E, cf. lanes 1 and 4), consistent with the idea that Pan2–Pan3S complex may digest the poly(A) tails all the way through to increase overall deadenylation."
28559491
sparser
"We propose that the first phase of deadenylation, involving differential actions of Pan2–Pan3S and Pan2–Pan3L, represents a previously unsuspected step of mRNA “maturation” in the cytoplasm, with the potential to modulate critical mRNP remodeling and influence the cytoplasmic fate of mRNA."
28559491
PAN2 affects PUF3
| 1 1
PAN2 binds PUF3. 2 / 2
| 1 1
reach
"An interaction between Pan2 and Puf3 could not be detected, suggesting that Puf3 affects the structure of the mRNA and the poly(A) tail-binding protein Pab1, thereby exposing the poly(A) tail to deade[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21115348
sparser
"An interaction between Pan2 and Puf3 could not be detected, suggesting that Puf3 affects the structure of the mRNA and the poly(A) tail-binding protein Pab1, thereby exposing the poly(A) tail to deade[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21115348
PAN2 affects PLEC
2 |
PAN2 binds PLEC. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23398456
PAN2 affects PABPC4
2 |
PAN2 binds PABPC4. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
23398456
PAN2 affects N
1 1 |
PAN2 binds N. 2 / 2
1 1 |
biogrid
No evidence text available
34709727
virhostnet
No evidence text available
34709727
PAN2 affects Lcp65Ag1
2 |
Lcp65Ag1 binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
14605208
biogrid
No evidence text available
14605208
PAN2 affects LZTS2
2 |
PAN2 binds LZTS2. 2 / 2
2 |
biogrid
No evidence text available
23398456
biogrid
No evidence text available
29395067
PAN2 affects LRG1
| 2
Modified PAN2 decreases the amount of LRG1. 2 / 2
| 2
reach
"However, the overexpression of PAN2 did not reduce Lrg1 level in the ccr4Delta background in the stationary phase (XREF_FIG)."
28231297
reach
"On the other hand, overexpression of PAN2 had little effect on LRG1 poly (A) tail length and did not reduce Lrg1 protein level in the ccr4Delta mutant."
28231297
PAN2 affects Host translation inhibitor nsp1
2 |
PAN2 affects HIF1
| 2
PAN2 activates HIF1. 2 / 2
| 2
reach
"The P-body component USP52/PAN2 can enhance the stability of HIF-1α mRNA, which is crucial under hypoxic conditions (170)."
38362920
reach
"This process effectively maintains low levels of expression for these stemness-associated factors.239 Moreover, the stability of HIF protein can be regulated by DUBs such as USP8, USP19, and USP28.240, 241, 242 Additionally, USP52 plays a crucial role in the P-body complex to prevent degradation of HIF-1α mRNA.243 Inflammation."
40034124
PAN2 affects CCT7
2 |
PAN2 binds CCT7. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23398456
PAN2 affects CCR4
1 | 1
PAN2 phosphorylates CCR4.
| 1
PAN2 phosphorylates phosphorylated CCR4. 1 / 1
| 1
reach
"Since Ccr4, Pan2, and Pan3 seem to be more phosphorylated in GlyLac medium, these phosphorylated Ccr4, Pan2, and Pan3 proteins might be required to maintain a proper homeostasis in low energy media.In[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34280615
PAN2 binds CCR4.
1 |
CCR4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
29158339
PAN2 affects ASF1B
2 |
ASF1B binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
PAN2 affects AKT
| 2
PAN2 inhibits AKT. 2 / 2
| 2
reach
"This study demonstrates that USP52 inhibits cancer cell proliferation through downregulation of cyclin D1 as well as AKT/mTOR signaling pathway inhibition."
34533198
reach
"In a similar vein, Zhu et al. demonstrated that USP52 stabilizes PTEN, downregulates cyclin D1, and inhibits the AKT/mTOR pathway, thereby suppressing cancer cell proliferation (41)."
39697746
PAN2 affects AGO2
| 2
AGO2 binds PAN2. 2 / 2
| 2
reach
"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."
25084349
reach
"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."
25084349
PABPC4 affects PAN2
2 |
PAN2 binds PABPC4. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
23398456
N affects PAN2
1 1 |
PAN2 binds N. 2 / 2
1 1 |
biogrid
No evidence text available
34709727
virhostnet
No evidence text available
34709727
Lcp65Ag1 affects PAN2
2 |
Lcp65Ag1 binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
14605208
biogrid
No evidence text available
14605208
LZTS2 affects PAN2
2 |
PAN2 binds LZTS2. 2 / 2
2 |
biogrid
No evidence text available
23398456
biogrid
No evidence text available
29395067
Host translation inhibitor nsp1 affects PAN2
2 |
HNF4A affects PAN2
2 |
HNF4A decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
HMGA1 affects PAN2
1 1 |
HMGA1 decreases the amount of PAN2.
1 |
HMGA1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
HMGA1 binds PAN2.
1 |
PAN2 binds HMGA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
E2F4 affects PAN2
2 |
E2F4 decreases the amount of PAN2. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
CNOT7 affects ETF1, PAN2, PAN3, ccr4, and eRF3
| 2
ERF3 binds ETF1, PAN3, PAN2, ccr4, and CNOT7. 2 / 2
| 2
sparser
"Interestingly, translation termination complexes eRF1-eRF3, Pan2-Pan3, and Caf1-Ccr4 competitively interact with polyadenylate-binding protein PABPC1."
18056425
sparser
"Recent studies showed that translation termination complexes eRF1–eRF3, Pan2–Pan3, and Caf1–Ccr4 competitively bind to PABPC1via the PAM2 motifs of eRF3, Pan3, and Tob."
20096703
CHAF1A affects PAN2
| 2
CHAF1A increases the amount of PAN2.
| 1
Mutated CHAF1A increases the amount of mutated PAN2. 1 / 1
| 1
reach
"Consistent with these observations, studies have revealed that whereas the overexpression of catalytically inactive CCR4a or CAF1 mutants inhibits silencing in a dominant-negative manner ( Chen et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29791863
CHAF1A decreases the amount of PAN2.
| 1
Mutated CHAF1A decreases the amount of mutated PAN2. 1 / 1
| 1
reach
"Consistent with these observations, studies have revealed that whereas the overexpression of catalytically inactive CCR4a or CAF1 mutants inhibits silencing in a dominant-negative manner ( Chen et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29791863
CCT7 affects PAN2
2 |
PAN2 binds CCT7. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23398456
BZU2 affects PAN2
| 2
BZU2 activates PAN2. 2 / 2
| 2
reach
"We speculate that BZU2/ZmMUTE combines with additional unknown factors to activate P3 of the PAN2 promoter in vivo (Fig 7, S7 Fig and S8 Fig), by analogy to the observation that the DNA binding specificity of AtMUTE depends on its dimerization partner ICE1 or SCRM2 [37]."
31465456
reach
"Unexpectedly, yeast one-hybrid and EMSA data show that BZU2/ZmMUTE is not able to activate P3 of the promoter of PAN2 in vitro, but the ChIP-qPCR data indicate that BZU2/ZmMUTE can activate P3 of the PAN2 promoter in vivo."
31465456
Air Pollutants affects PAN2
2 |
Air Pollutants increases the amount of PAN2.
1 |
Air Pollutants increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
32699268
Air Pollutants decreases the amount of PAN2.
1 |
Air Pollutants decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
21757418
ASF1B affects PAN2
2 |
ASF1B binds PAN2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
AGO2 affects PAN2
| 2
AGO2 binds PAN2. 2 / 2
| 2
reach
"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."
25084349
reach
"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."
25084349
Volatile organic compound increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
32699268
Uracil affects PAN2
| 1
Uracil inhibits PAN2. 1 / 1
| 1
eidos
"The Stacked , Helical Structure of Poly ( A ) is Important in Deadenylation In vitro deadenylation assays showed that Pan2 was not strongly inhibited by uracils ( Us ) or cytosines ( Cs ) at the end of a poly ( A ) tail ( Fig. 3A , B ) , but these nucleotides did not show the characteristic CD signature of helical poly ( A ) , either alone ( Fig. 3E ) or in the context of oligo ( A ) ( Fig. 4A ) ."
32295929
Twit affects PAN2
1 |
PAN2 binds twit. 1 / 1
1 |
biogrid
No evidence text available
14605208
Topotecan affects PAN2
1 |
Topotecan decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25729387
Thiram affects PAN2
1 |
Thiram decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
38568856
Thioacetamide affects PAN2
1 |
Thioacetamide decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
34492290
Temozolomide affects PAN2
1 |
Temozolomide increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
31758290
Step affects PAN2
1 |
Step binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
14605208
Sorafenib affects PAN2
1 |
Sorafenib increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
39786591
Sodium arsenite affects PAN2
1 |
Sodium arsenite decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
38568856
Resveratrol affects PAN2
1 |
Resveratrol increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23557933
Quercetin affects PAN2
1 |
Quercetin phosphorylates PAN2. 1 / 1
1 |
ctd
No evidence text available
35688186
Phorbol 13-acetate 12-myristate decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25613284
Perfluorooctanesulfonamide decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
39104825
Perfluorooctane-1-sulfonic acid decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
37528559
Paracetamol affects PAN2
1 |
Paracetamol decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
21420995
Pan affects PAN2
| 1
PAN2 binds pan. 1 / 1
| 1
reach
"HuR may modulate translation of several ARE-mRNAs by a process that is independent of ARE or 3 ' UTR, which involves binding of HuR to IRES in the 5 ' UTR.19, 20, 21 AREs mediate their effects on mRNA decay by first enhancing deadenylation (polyA shortening), a first step in mRNA decay facilitated by CCR4 and NOT and PAN2 and PAN complexes."
27251431
Oxaliplatin affects PAN2
1 |
Oxaliplatin decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25729387
Nanos affects PAN2
1 |
Nanos binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
26968986
Methyl methanesulfonate increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23649840
Methacrylaldehyde affects PAN2
1 |
Methacrylaldehyde increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
32699268
Hsa-mir-3672 affects PAN2
1 |
Hsa-mir-3672 decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-mir-3155b affects PAN2
1 |
Hsa-mir-3155b decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-875-5p affects PAN2
1 |
Hsa-miR-875-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-8055 affects PAN2
1 |
Hsa-miR-8055 decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-770-5p affects PAN2
1 |
Hsa-miR-770-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24374217
Hsa-miR-6826-3p affects PAN2
1 |
Hsa-miR-6826-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6756-3p affects PAN2
1 |
Hsa-miR-6756-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6726-3p affects PAN2
1 |
Hsa-miR-6726-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5587-5p affects PAN2
1 |
Hsa-miR-5587-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4764-3p affects PAN2
1 |
Hsa-miR-4764-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-454-5p affects PAN2
1 |
Hsa-miR-454-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4446-5p affects PAN2
1 |
Hsa-miR-4446-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-377-5p affects PAN2
1 |
Hsa-miR-377-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24374217
Hsa-miR-3663-5p affects PAN2
1 |
Hsa-miR-3663-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3144-3p affects PAN2
1 |
Hsa-miR-3144-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3127-3p affects PAN2
1 |
Hsa-miR-3127-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-302b-5p affects PAN2
1 |
Hsa-miR-302b-5p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-29a-3p affects PAN2
1 |
Hsa-miR-29a-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-222-3p affects PAN2
1 |
Hsa-miR-222-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-1249-3p affects PAN2
1 |
Hsa-miR-1249-3p decreases the amount of PAN2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hexabromocyclododecane decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
29177809
Gw affects PAN2
1 |
Gw binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
21981923
Furan affects PAN2
1 |
Furan demethylates PAN2. 1 / 1
1 |
ctd
No evidence text available
22079235
Fulvestrant affects PAN2
1 |
Fulvestrant methylates PAN2. 1 / 1
1 |
ctd
No evidence text available
31601247
Formaldehyde affects PAN2
1 |
Formaldehyde increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23649840
Folic acid affects PAN2
1 |
Folic acid increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
22206623
Flutamide affects PAN2
1 |
Flutamide increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
24793618
Exonuclease affects PAN3
| 1
Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
Exonuclease affects BLNK
| 1
PAN2 binds exonuclease, BLNK, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
Endosulfan affects PAN2
1 |
Endosulfan decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
29391264
Dorsomorphin affects PAN2
1 |
Dorsomorphin decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
27188386
Cytoplasmic poly A binding protein PABPC1 is cofactor affects PAN2
| 1
Cytoplasmic poly A binding protein PABPC1 is cofactor activates PAN2. 1 / 1
| 1
eidos
"Poliovirus proteases also target and degrade a variety of cellular proteins , including the cytoplasmic poly ( A ) binding protein PABPC1 [ 47 ] , which is a cofactor that stimulates the Pan2 / 3 deadenylase ."
21640425
Cyclosporin A affects PAN2
1 |
Cyclosporin A increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
27989131
Coumestrol affects PAN2
1 |
Coumestrol increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
19167446
Copper(II) sulfate affects PAN2
1 |
Copper(II) sulfate decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
19549813
Cobalt dichloride affects PAN2
1 |
Cobalt dichloride decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
19376846
Chlorpyrifos affects PAN2
1 |
Chlorpyrifos decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
37019170
Ccr4 affects Nuclease
| 1
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
Ccr4 affects BLNK
| 1
PAN2 binds exonuclease, BLNK, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
Cbt affects PAN2
1 |
Cbt binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
14605208
Cadmium dichloride affects PAN2
1 |
Cadmium dichloride decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
38568856
Butanal affects PAN2
1 |
Butanal decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
26079696
Bis(2-ethylhexyl) phthalate increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
34319233
Beta-lapachone affects PAN2
1 |
Beta-lapachone decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
38218311
Benzo[a]pyrene affects PAN2
1 |
Benzo[a]pyrene demethylates PAN2. 1 / 1
1 |
ctd
No evidence text available
27901495
Base-stacking affects PAN2
| 1
Base-stacking activates PAN2. 1 / 1
| 1
eidos
"This supports the finding that disruption of base-stacking inhibits Pan2 , and that Pan2 requires its substrate to adopt a poly ( A ) - like stacked , helical conformation ."
32295929
Arsenous acid affects PAN2
1 |
Arsenous acid decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
27829220
Alpha-pinene affects PAN2
1 |
Alpha-pinene increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
32699268
Aflatoxin B1 affects PAN2
1 |
Aflatoxin B1 methylates PAN2. 1 / 1
1 |
ctd
No evidence text available
27153756
Abrine affects PAN2
1 |
Abrine increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
31054353
ZmMUTE affects PAN2
| 1
ZmMUTE activates PAN2. 1 / 1
| 1
reach
"Unexpectedly, yeast one-hybrid and EMSA data show that BZU2/ZmMUTE is not able to activate P3 of the promoter of PAN2 in vitro, but the ChIP-qPCR data indicate that BZU2/ZmMUTE can activate P3 of the PAN2 promoter in vivo."
31465456
ZNF234 affects PAN2
1 |
PAN2 binds ZNF234. 1 / 1
1 |
biogrid
No evidence text available
23398456
YWHAE affects PAN2
1 |
PAN2 binds YWHAE. 1 / 1
1 |
biogrid
No evidence text available
23398456
YML6 affects PAN2
1 |
YML6 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
YIP5 affects PAN2
1 |
YIP5 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
YES1 affects PAN2
1 |
PAN2 binds YES1. 1 / 1
1 |
biogrid
No evidence text available
23398456
YBX3 affects PAN2
1 |
PAN2 binds YBX3. 1 / 1
1 |
biogrid
No evidence text available
23398456
YBX1 affects PAN2
1 |
PAN2 binds YBX1. 1 / 1
1 |
biogrid
No evidence text available
23398456
XRN2 affects PAN2
1 |
PAN2 binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
VPS15 affects PAN2
1 |
VPS15 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
VIM affects PAN2
1 |
PAN2 binds VIM. 1 / 1
1 |
biogrid
No evidence text available
23398456
VDR affects PAN2
1 |
VDR decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
URE2 affects PAN2
1 |
PAN2 binds URE2. 1 / 1
1 |
biogrid
No evidence text available
37968396
UBTD1 affects PAN2
1 |
PAN2 binds UBTD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
UBP1 affects PAN2
1 |
UBP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
UBI4 affects PAN2
1 |
UBI4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
38803224
UACA affects PAN2
1 |
PAN2 binds UACA. 1 / 1
1 |
biogrid
No evidence text available
23398456
Tobacco Smoke Pollution decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
33660061
TXN affects PAN2
1 |
PAN2 binds TXN. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUFM affects PAN2
1 |
PAN2 binds TUFM. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUBB4B affects PAN2
1 |
PAN2 binds TUBB4B. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUBB affects PAN2
1 |
PAN2 binds TUBB. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUBA1B affects PAN2
1 |
PAN2 binds TUBA1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
TUBA1A affects PAN2
1 |
PAN2 binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
TSR3 affects PAN2
1 |
PAN2 binds TSR3. 1 / 1
1 |
biogrid
No evidence text available
37968396
TRIM35 affects PAN2
1 |
PAN2 binds TRIM35. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM21 affects PAN2
1 |
PAN2 binds TRIM21. 1 / 1
1 |
biogrid
No evidence text available
23398456
TPM4 affects PAN2
1 |
PAN2 binds TPM4. 1 / 1
1 |
biogrid
No evidence text available
23398456
TPM3P4 affects PAN2
1 |
PAN2 binds TPM3P4. 1 / 1
1 |
biogrid
No evidence text available
23398456
TPM3 affects PAN2
1 |
PAN2 binds TPM3. 1 / 1
1 |
biogrid
No evidence text available
23398456
TPM1 affects PAN2
1 |
PAN2 binds TPM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
TP53 affects PAN2
1 |
PAN2 binds TP53. 1 / 1
1 |
biogrid
No evidence text available
23398456
TOB2 affects PAN2
1 |
TOB2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
17785442
TNRC6B affects PAN2
1 |
TNRC6B binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
29395067
TNRC6A affects PAN2
1 |
TNRC6A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
21984185
TMOD3 affects PAN2
1 |
PAN2 binds TMOD3. 1 / 1
1 |
biogrid
No evidence text available
23398456
TMOD2 affects PAN2
1 |
PAN2 binds TMOD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
TLX2 affects PAN2
1 |
TLX2 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
TJP1 affects PAN2
1 |
PAN2 binds TJP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
TFAM affects PAN2
1 |
PAN2 binds TFAM. 1 / 1
1 |
biogrid
No evidence text available
23398456
TCOF1 affects PAN2
1 |
PAN2 binds TCOF1. 1 / 1
1 |
biogrid
No evidence text available
23398456
SWD3 affects PAN2
1 |
SWD3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
SVIL affects PAN2
1 |
PAN2 binds SVIL. 1 / 1
1 |
biogrid
No evidence text available
23398456
STMN1 affects PAN2
1 |
PAN2 binds STMN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
STING1 affects PAN2
1 |
PAN2 binds STING1. 1 / 1
1 |
biogrid
No evidence text available
27801882
STAT5A affects PAN2
1 |
STAT5A decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
SSN8 affects PAN2
1 |
SSN8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
SRSF8 affects PAN2
1 |
PAN2 binds SRSF8. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRSF3 affects PAN2
1 |
PAN2 binds SRSF3. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRRM2 affects PAN2
1 |
PAN2 binds SRRM2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SRP14 affects PAN2
1 |
PAN2 binds SRP14. 1 / 1
1 |
biogrid
No evidence text available
23398456
SPTBN1 affects PAN2
1 |
PAN2 binds SPTBN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
SPTAN1 affects PAN2
1 |
PAN2 binds SPTAN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
SPECC1L affects PAN2
1 |
PAN2 binds SPECC1L. 1 / 1
1 |
biogrid
No evidence text available
23398456
SP1 affects PAN2
1 |
SP1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
SOWAHA affects PAN2
1 |
SOWAHA binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
SOL2 affects PAN2
1 |
SOL2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
SNRPD2 affects PAN2
1 |
PAN2 binds SNRPD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SNRPD1 affects PAN2
1 |
PAN2 binds SNRPD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
SNRNP70 affects PAN2
1 |
PAN2 binds SNRNP70. 1 / 1
1 |
biogrid
No evidence text available
23398456
SNAI1 affects PAN2
1 |
SNAI1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
31911859
SMPDL3B affects PAN2
1 |
PAN2 binds SMPDL3B. 1 / 1
1 |
biogrid
No evidence text available
23398456
SMN2 affects PAN2
1 |
PAN2 binds SMN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
SIT4 affects PAN2
1 |
SIT4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
SF3B6 affects PAN2
1 |
PAN2 binds SF3B6. 1 / 1
1 |
biogrid
No evidence text available
23398456
SERBP1 affects PAN2
1 |
PAN2 binds SERBP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
SER2 affects PAN2
1 |
SER2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
SEM1 affects PAN2
1 |
SEM1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
16554755
SEG2 affects PAN2
1 |
PAN2 binds SEG2. 1 / 1
1 |
biogrid
No evidence text available
37968396
SEC16A affects PAN2
1 |
PAN2 binds SEC16A. 1 / 1
1 |
biogrid
No evidence text available
23398456
SAM4 affects PAN2
1 |
SAM4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
RSC8 affects PAN2
1 |
RSC8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
RRP1 affects PAN2
1 |
PAN2 binds RRP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
RRAS2 affects PAN2
1 |
PAN2 binds RRAS2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS9 affects PAN2
1 |
PAN2 binds RPS9. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS7 affects PAN2
1 |
PAN2 binds RPS7. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS4X affects PAN2
1 |
PAN2 binds RPS4X. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS3A affects PAN2
1 |
PAN2 binds RPS3A. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS3 affects PAN2
1 |
PAN2 binds RPS3. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS26 affects PAN2
1 |
PAN2 binds RPS26. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS24 affects PAN2
1 |
PAN2 binds RPS24. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS23 affects PAN2
1 |
PAN2 binds RPS23. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS19 affects PAN2
1 |
PAN2 binds RPS19. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS18 affects PAN2
1 |
PAN2 binds RPS18. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS17 affects PAN2
1 |
PAN2 binds RPS17. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS15A affects PAN2
1 |
PAN2 binds RPS15A. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS12 affects PAN2
1 |
PAN2 binds RPS12. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPS11 affects PAN2
1 |
PAN2 binds RPS11. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPLP0 affects PAN2
1 |
PAN2 binds RPLP0. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL7A affects PAN2
1 |
PAN2 binds RPL7A. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL7 affects PAN2
1 |
PAN2 binds RPL7. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL5 affects PAN2
1 |
PAN2 binds RPL5. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL4 affects PAN2
1 |
PAN2 binds RPL4. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL38 affects PAN2
1 |
PAN2 binds RPL38. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL36 affects PAN2
1 |
PAN2 binds RPL36. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL35 affects PAN2
1 |
PAN2 binds RPL35. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL34 affects PAN2
1 |
PAN2 binds RPL34. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL32 affects PAN2
1 |
PAN2 binds RPL32. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL31 affects PAN2
1 |
PAN2 binds RPL31. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL3 affects PAN2
1 |
PAN2 binds RPL3. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL29 affects PAN2
1 |
PAN2 binds RPL29. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL28 affects PAN2
1 |
PAN2 binds RPL28. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL27 affects PAN2
1 |
PAN2 binds RPL27. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL26L1 affects PAN2
1 |
PAN2 binds RPL26L1. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL26 affects PAN2
1 |
PAN2 binds RPL26. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL24 affects PAN2
1 |
PAN2 binds RPL24. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL23A affects PAN2
1 |
PAN2 binds RPL23A. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL23 affects PAN2
1 |
PAN2 binds RPL23. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL21 affects PAN2
1 |
PAN2 binds RPL21. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL19 affects PAN2
1 |
PAN2 binds RPL19. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL18A affects PAN2
1 |
PAN2 binds RPL18A. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL18 affects PAN2
1 |
PAN2 binds RPL18. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL17 affects PAN2
1 |
PAN2 binds RPL17. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL15 affects PAN2
1 |
PAN2 binds RPL15. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL13A affects PAN2
1 |
PAN2 binds RPL13A. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL13 affects PAN2
1 |
PAN2 binds RPL13. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPL10A affects PAN2
1 |
PAN2 binds RPL10A. 1 / 1
1 |
biogrid
No evidence text available
23398456
RPA2 affects PAN2
1 |
PAN2 binds RPA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RNPC3 affects PAN3
| 1
PAN3 binds PAN2 and RNPC3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
RNF2 affects PAN2
1 |
PAN2 binds RNF2. 1 / 1
1 |
biogrid
No evidence text available
27173435
RNF144B affects PAN2
1 |
PAN2 binds RNF144B. 1 / 1
1 |
biogrid
No evidence text available
23105109
RIF1 affects PAN2
1 |
RIF1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
RCN2 affects PAN2
1 |
PAN2 binds RCN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
RBM10 affects PAN2
1 |
PAN2 binds RBM10. 1 / 1
1 |
biogrid
No evidence text available
23398456
RBCK1 affects PAN2
1 |
PAN2 binds RBCK1. 1 / 1
1 |
biogrid
No evidence text available
23105109
RBBP4 affects PAN2
1 |
PAN2 binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
23398456
Plant Extracts affects PAN2
1 |
Plant Extracts increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23557933
Particulate Matter affects PAN2
1 |
Particulate Matter increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
17295261
Pab1p affects PAN2
| 1
Pab1p activates PAN2. 1 / 1
| 1
reach
"While Pab1p stimulates PAN2, the association of poly (A) binding proteins with human or Xenopus mRNAs appears to protect the transcript from deadenylation (Bernstein et al. 1989; Brown et al. 1996; Wo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10882133
PSMC5 affects PAN2
1 |
PAN2 binds PSMC5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PRNP affects PAN2
1 |
PAN2 binds PRNP. 1 / 1
1 |
biogrid
No evidence text available
23398456
PRMT5 affects PAN2
1 |
PAN2 binds PRMT5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PPP1R12A affects PAN2
1 |
PAN2 binds PPP1R12A. 1 / 1
1 |
biogrid
No evidence text available
23398456
POM121C affects PAN2
1 |
PAN2 binds POM121C. 1 / 1
1 |
biogrid
No evidence text available
27173435
POM121 affects PAN2
1 |
PAN2 binds POM121. 1 / 1
1 |
biogrid
No evidence text available
27173435
PKM affects PAN2
1 |
PAN2 binds PKM. 1 / 1
1 |
biogrid
No evidence text available
23398456
PHO4 affects PAN2
1 |
PHO4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PHB2 affects PAN2
1 |
PHB2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PGC1 affects PAN2
1 |
PGC1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PFDN2 affects PAN2
1 |
PAN2 binds PFDN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PEX12 affects PAN2
1 |
PAN2 binds PEX12. 1 / 1
1 |
biogrid
No evidence text available
37968396
PET123 affects PAN2
1 |
PET123 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PCM1 affects PAN2
1 |
PAN2 binds PCM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PCBP1 affects PAN2
1 |
PAN2 binds PCBP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PBP1 affects PAN2
1 |
PAN2 binds PBP1. 1 / 1
1 |
biogrid
No evidence text available
15169912
PAWR affects PAN2
1 |
PAN2 binds PAWR. 1 / 1
1 |
biogrid
No evidence text available
23398456
PARP1 affects PAN2
1 |
PAN2 binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN3 affects exonuclease
| 1
Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN3 affects RNPC3
| 1
PAN3 binds PAN2 and RNPC3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
PAN3 affects PABPC1
1 |
PABPC1 binds PAN2 and PAN3. 1 / 1
1 |
hprd
No evidence text available
18056425
PAN3 affects Nuclease
| 1
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN3 affects MTA2
| 1
MTA2 binds PAN3 and PAN2. 1 / 1
| 1
sparser
"In summary, we found that it was difficult to disrupt the Pan2–Pan3 interaction by deletion of substantial regions of ct Pan2 PID and show that a core region (residues 343–406) makes a major contribution to the association of ct Pan2 and ct Pan3."
24872509
PAN3 affects MARF1
| 1
MARF1 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
30279526
PAN2 affects twit
1 |
PAN2 binds twit. 1 / 1
1 |
biogrid
No evidence text available
14605208
PAN2 affects transport
| 1
PAN2 inhibits transport. 1 / 1
| 1
reach
"An alternative view is that since a pan2 defect can block mRNA transport out of the nucleus in 50% of the cells observed, the combination of a ccr4 deletion and this transport defect is the cause for the lack of COX17 mRNA deadenylation in the ccr4 pan2 strain background."
20435044
PAN2 affects step
1 |
Step binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
14605208
PAN2 activates signal transduction. 1 / 1
| 1
reach
"This study demonstrates that USP52 inhibits cancer cell proliferation through downregulation of cyclin D1 as well as AKT/mTOR signaling pathway inhibition."
34533198
PAN2 affects response to hypoxia
| 1
PAN2 activates response to hypoxia. 1 / 1
| 1
reach
"Interestingly, it has been reported previously that USP52 and KIAA0710 mRNA itself was induced 3.1-fold in response to hypoxia determined by microarray analysis of human renal cancer 786-O cells [XREF_BIBR]."
23398456
PAN2 affects pan
| 1
PAN2 binds pan. 1 / 1
| 1
reach
"HuR may modulate translation of several ARE-mRNAs by a process that is independent of ARE or 3 ' UTR, which involves binding of HuR to IRES in the 5 ' UTR.19, 20, 21 AREs mediate their effects on mRNA decay by first enhancing deadenylation (polyA shortening), a first step in mRNA decay facilitated by CCR4 and NOT and PAN2 and PAN complexes."
27251431
PAN2 affects nanos
1 |
Nanos binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
26968986
PAN2 affects hydrogen sulfide
| 1
PAN2 activates hydrogen sulfide. 1 / 1
| 1
reach
"The paN2 allows Escherichia coli to liberate the sulfur of DBT and DBTs and pBADD produces a flavin reductase."
16736591
PAN2 bound to RBBP8 activates homologous recombination. 1 / 1
| 1
reach
"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
PAN2 affects gw
1 |
Gw binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
21981923
PAN2 affects dapL
| 1
PAN2 activates dapL. 1 / 1
| 1
reach
"Indeed, Pan-2/pXtuf-panBCD cells overexpressing aspB produced 0.38 g/L D-PA."
36609377
PAN2 affects cbt
1 |
Cbt binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
14605208
PAN2 affects ZNF234
1 |
PAN2 binds ZNF234. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects YWHAE
1 |
PAN2 binds YWHAE. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects YTHDF3
1 |
YTHDF3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
29395067
PAN2 affects YML6
1 |
YML6 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects YIP5
1 |
YIP5 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects YES1
1 |
PAN2 binds YES1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects YBX3
1 |
PAN2 binds YBX3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects YBX1
1 |
PAN2 binds YBX1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects XRN2
1 |
PAN2 binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects Werner Syndrome
| 1
PAN2 activates Werner Syndrome. 1 / 1
| 1
reach
"1 , oligoribonuclease, exonuclease domain of family B DNA polymerases, the Saccharomyces cerevisiae PAN2 protein, the human Exonuclease ERI1, Interferon-stimulated gene 20 kDa protein (ISG20), Exosome[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20638361
PAN2 affects WRN
| 1
PAN2 activates WRN. 1 / 1
| 1
reach
"1 , oligoribonuclease, exonuclease domain of family B DNA polymerases, the Saccharomyces cerevisiae PAN2 protein, the human Exonuclease ERI1, Interferon-stimulated gene 20 kDa protein (ISG20), Exosome[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20638361
PAN2 affects VPS15
1 |
VPS15 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects VIM
1 |
PAN2 binds VIM. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects USP52in
| 1
PAN2 activates USP52in. 1 / 1
| 1
reach
"To investigate further the role of USP52in the HIF1A mediated hypoxic response, U2OS cells were treated with individual USP52 siRNA duplexes 1 and 3 and exposed to hypoxia."
23398456
PAN2 affects URE2
1 |
PAN2 binds URE2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects UBTD1
1 |
PAN2 binds UBTD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects UBP1
1 |
UBP1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects UBI4
1 |
UBI4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
38803224
PAN2 affects UACA
1 |
PAN2 binds UACA. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TXN
1 |
PAN2 binds TXN. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUFM
1 |
PAN2 binds TUFM. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUBB4B
1 |
PAN2 binds TUBB4B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUBB
1 |
PAN2 binds TUBB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUBA1B
1 |
PAN2 binds TUBA1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TUBA1A
1 |
PAN2 binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TSR3
1 |
PAN2 binds TSR3. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects TRIM35
1 |
PAN2 binds TRIM35. 1 / 1
1 |
biogrid
No evidence text available
23105109
PAN2 affects TRIM21
1 |
PAN2 binds TRIM21. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TPM4
1 |
PAN2 binds TPM4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TPM3P4
1 |
PAN2 binds TPM3P4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TPM3
1 |
PAN2 binds TPM3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TPM1
1 |
PAN2 binds TPM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TP53
1 |
PAN2 binds TP53. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TOB2
1 |
TOB2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
17785442
PAN2 affects TNRC6B
1 |
TNRC6B binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
29395067
PAN2 affects TNRC6A
1 |
TNRC6A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
21984185
PAN2 affects TMOD3
1 |
PAN2 binds TMOD3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TMOD2
1 |
PAN2 binds TMOD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TJP1
1 |
PAN2 binds TJP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TFAM
1 |
PAN2 binds TFAM. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects TCOF1
1 |
PAN2 binds TCOF1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SWD3
1 |
SWD3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects SVIL
1 |
PAN2 binds SVIL. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects STMN1
1 |
PAN2 binds STMN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects STING1
1 |
PAN2 binds STING1. 1 / 1
1 |
biogrid
No evidence text available
27801882
PAN2 affects SSN8
1 |
SSN8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects SRSF8
1 |
PAN2 binds SRSF8. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRSF3
1 |
PAN2 binds SRSF3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRRM2
1 |
PAN2 binds SRRM2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SRP14
1 |
PAN2 binds SRP14. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SPTBN1
1 |
PAN2 binds SPTBN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SPTAN1
1 |
PAN2 binds SPTAN1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SPECC1L
1 |
PAN2 binds SPECC1L. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SOWAHA
1 |
SOWAHA binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects SOL2
1 |
SOL2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects SNRPD2
1 |
PAN2 binds SNRPD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SNRPD1
1 |
PAN2 binds SNRPD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SNRNP70
1 |
PAN2 binds SNRNP70. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SNAI1
1 |
SNAI1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
31911859
PAN2 affects SMPDL3B
1 |
PAN2 binds SMPDL3B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SMN2
1 |
PAN2 binds SMN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SLC2A1
| 1
PAN2 inhibits SLC2A1. 1 / 1
| 1
reach
"Examination of GLUT1 and LDHA levels by immunoblot analysis of hypoxic U2OS cells revealed that USP52 depletion impairs the accumulation of GLUT1 and LDHA in response to hypoxia (XREF_FIG A), thus demonstrating that USP52 is required to potentiate the HIF1A mediated hypoxic response."
23398456
PAN2 affects SIT4
1 |
SIT4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects SF3B6
1 |
PAN2 binds SF3B6. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SERBP1
1 |
PAN2 binds SERBP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SER2
1 |
SER2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects SEM1
1 |
SEM1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
16554755
PAN2 affects SEG2
1 |
PAN2 binds SEG2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects SEC16A
1 |
PAN2 binds SEC16A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects SAM4
1 |
SAM4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects RSC8
1 |
RSC8 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects RRP1
1 |
PAN2 binds RRP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RRAS2
1 |
PAN2 binds RRAS2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS9
1 |
PAN2 binds RPS9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS7
1 |
PAN2 binds RPS7. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS4X
1 |
PAN2 binds RPS4X. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS3A
1 |
PAN2 binds RPS3A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS3
1 |
PAN2 binds RPS3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS26
1 |
PAN2 binds RPS26. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS24
1 |
PAN2 binds RPS24. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS23
1 |
PAN2 binds RPS23. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS19
1 |
PAN2 binds RPS19. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS18
1 |
PAN2 binds RPS18. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS17
1 |
PAN2 binds RPS17. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS15A
1 |
PAN2 binds RPS15A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS12
1 |
PAN2 binds RPS12. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPS11
1 |
PAN2 binds RPS11. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPLP0
1 |
PAN2 binds RPLP0. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL7A
1 |
PAN2 binds RPL7A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL7
1 |
PAN2 binds RPL7. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL5
1 |
PAN2 binds RPL5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL4
1 |
PAN2 binds RPL4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL38
1 |
PAN2 binds RPL38. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL36
1 |
PAN2 binds RPL36. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL35
1 |
PAN2 binds RPL35. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL34
1 |
PAN2 binds RPL34. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL32
1 |
PAN2 binds RPL32. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL31
1 |
PAN2 binds RPL31. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL3
1 |
PAN2 binds RPL3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL29
1 |
PAN2 binds RPL29. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL28
1 |
PAN2 binds RPL28. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL27
1 |
PAN2 binds RPL27. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL26L1
1 |
PAN2 binds RPL26L1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL26
1 |
PAN2 binds RPL26. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL24
1 |
PAN2 binds RPL24. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL23A
1 |
PAN2 binds RPL23A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL23
1 |
PAN2 binds RPL23. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL21
1 |
PAN2 binds RPL21. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL19
1 |
PAN2 binds RPL19. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL18A
1 |
PAN2 binds RPL18A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL18
1 |
PAN2 binds RPL18. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL17
1 |
PAN2 binds RPL17. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL15
1 |
PAN2 binds RPL15. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL13A
1 |
PAN2 binds RPL13A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL13
1 |
PAN2 binds RPL13. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPL10A
1 |
PAN2 binds RPL10A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RPA2
1 |
PAN2 binds RPA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RNPC3
| 1
PAN3 binds PAN2 and RNPC3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
PAN2 affects RNF2
1 |
PAN2 binds RNF2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects RNF144B
1 |
PAN2 binds RNF144B. 1 / 1
1 |
biogrid
No evidence text available
23105109
PAN2 affects RNAPII
| 1
PAN2 activates RNAPII. 1 / 1
| 1
reach
"Finally, although knockdown of Ccr4 alone did notimpact the reduction of RNAPII promoter occupancy in muSOX expressing cells, co-depletion of both Ccr4 and Pan2 restored RNAPII occupancy at the Gapdh promoter (XREF_FIG E)."
26211836
PAN2 affects RNAPII promoter
| 1
PAN2 inhibits RNAPII promoter. 1 / 1
| 1
reach
"Conversely, our observation that knockdown of the Ccr4 and Pan2 deadenylases increased RNAPII promoter occupancy in uninfected cells suggests that decreased cytoplasmic decay stimulates transcription in mammalian cells."
26211836
PAN2 affects RIF1
1 |
RIF1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects RCN2
1 |
PAN2 binds RCN2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RBM10
1 |
PAN2 binds RBM10. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects RBCK1
1 |
PAN2 binds RBCK1. 1 / 1
1 |
biogrid
No evidence text available
23105109
PAN2 affects RBBP4
1 |
PAN2 binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects Proteasome
| 1
PAN2 activates Proteasome. 1 / 1
| 1
reach
"Further research, along with the development of specific analytical pipelines, will be essential to explore the implications of this 20S association more comprehensively.Additionally, the validation of PAN-2, a new PAN-like molecule from the archaeal organism Methanocaldococcus jannaschii, which binds to and activates the archaeal 20S proteasome, illustrates another significant application of the ProEnd database."
39396964
PAN2 affects PSMC5
1 |
PAN2 binds PSMC5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PRNP
1 |
PAN2 binds PRNP. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PRMT5
1 |
PAN2 binds PRMT5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PPP1R12A
1 |
PAN2 binds PPP1R12A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects POM121C
1 |
PAN2 binds POM121C. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects POM121
1 |
PAN2 binds POM121. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects PKM
1 |
PAN2 binds PKM. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PHO4
1 |
PHO4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects PHB2
1 |
PHB2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects PGC1
1 |
PGC1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects PFDN2
1 |
PAN2 binds PFDN2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects PEX12
1 |
PAN2 binds PEX12. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects PET123
1 |
PET123 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects PCM1
1 |
PAN2 binds PCM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PCBP1
1 |
PAN2 binds PCBP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PBP1
1 |
PAN2 binds PBP1. 1 / 1
1 |
biogrid
No evidence text available
15169912
PAN2 affects PAWR
1 |
PAN2 binds PAWR. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PARP1
1 |
PAN2 binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects PAN3, ccr4, and exonuclease
| 1
Ccr4 binds PAN3, PAN2, and exonuclease. 1 / 1
| 1
sparser
"Of note, Ago2 is also known to regulate mRNA silencing through interacting with exonuclease complexes, the Ccr4-Not and Pan2-Pan3 complexes xref , in a miRNA-independent manner, which likely contributes to suppression of protein translation and energy metabolism in the liver."
30201950
PAN2 affects PAN3, and RNPC3
| 1
PAN3 binds PAN2 and RNPC3. 1 / 1
| 1
sparser
"We concluded that Pan2-Pan3 does not stably interact with short poly(A) RNPs containing a single Pab1 but requires longer poly(A) RNPs containing two or more Pab1 protomers."
31104843
PAN2 affects PAN2
| 1
PAN2 phosphorylates PAN2. 1 / 1
| 1
reach
"Since Ccr4, Pan2, and Pan3 seem to be more phosphorylated in GlyLac medium, these phosphorylated Ccr4, Pan2, and Pan3 proteins might be required to maintain a proper homeostasis in low energy media.In[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34280615
PAN2 affects PACSIN3
1 |
PAN2 binds PACSIN3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects Nuclease
| 1
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
PAN2 affects Nanos
| 1
Nanos binds PAN2. 1 / 1
| 1
reach
"Nanos interacted with NOT1, NOT2, NOT3, PAN2, and PAN3 (Figs XREF_FIG A-D and XREF_FIG G-M)."
26968986
PAN2 affects NUP50
1 |
NUP50 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects NSMCE2
1 |
PAN2 binds NSMCE2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects NPM1
1 |
PAN2 binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects NOLC1
1 |
PAN2 binds NOLC1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects NISCH
1 |
PAN2 binds NISCH. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects NEXN
1 |
PAN2 binds NEXN. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO6
1 |
PAN2 binds MYO6. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO5C
1 |
PAN2 binds MYO5C. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO5B
1 |
PAN2 binds MYO5B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO5A
1 |
PAN2 binds MYO5A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO1E
1 |
PAN2 binds MYO1E. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO1D
1 |
PAN2 binds MYO1D. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO1C
1 |
PAN2 binds MYO1C. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO18A
1 |
PAN2 binds MYO18A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYO10
1 |
PAN2 binds MYO10. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYL6B
1 |
PAN2 binds MYL6B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYH9
1 |
PAN2 binds MYH9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYH10
1 |
PAN2 binds MYH10. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MYCBP
1 |
PAN2 binds MYCBP. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MTOR
| 1
PAN2 inhibits MTOR. 1 / 1
| 1
reach
"In a similar vein, Zhu et al. demonstrated that USP52 stabilizes PTEN, downregulates cyclin D1, and inhibits the AKT/mTOR pathway, thereby suppressing cancer cell proliferation (41)."
39697746
PAN2 affects MTA2
| 1
MTA2 binds PAN3 and PAN2. 1 / 1
| 1
sparser
"In summary, we found that it was difficult to disrupt the Pan2–Pan3 interaction by deletion of substantial regions of ct Pan2 PID and show that a core region (residues 343–406) makes a major contribution to the association of ct Pan2 and ct Pan3."
24872509
PAN2 affects MT1M
1 |
PAN2 binds MT1M. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects MRPL10
1 |
MRPL10 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects MIA
| 1
PAN2 binds MIA. 1 / 1
| 1
sparser
"Increased expressions of PPARA1, ACAA1, FABP1, and FABP2 were detected in SNU-478 ampullary cancer cells compared to pancreatic cancer cells (Pan1 and MIA-Pan2) and gastric cancer cells (AGS) by qPCR ( xref A-D)."
33390794
PAN2 affects MEX3C
1 |
MEX3C binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
26471122
PAN2 affects MEX3A
1 |
MEX3A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
36112059
PAN2 affects MECP2
1 |
MECP2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
38697112
PAN2 affects MCM2
1 |
MCM2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects MAP1B
1 |
PAN2 binds MAP1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects Lcp65Ag3
1 |
Lcp65Ag3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
14605208
PAN2 affects LYN
1 |
PAN2 binds LYN. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LSM1
1 |
PAN2 binds LSM1. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects LRR-RLK partner(s)
| 1
PAN2 activates LRR-RLK partner(s). 1 / 1
| 1
reach
"However, both PAN1 and PAN2 are catalytically inactive, raising the possibility that there may be one or more unidentified catalytically active LRR-RLK partner(s) that might act as coreceptors [ 22 ••[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23044038
PAN2 affects LMNB2
1 |
PAN2 binds LMNB2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LIMA1
1 |
PAN2 binds LIMA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LGALS8
1 |
PAN2 binds LGALS8. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects LDHA
| 1
PAN2 inhibits LDHA. 1 / 1
| 1
reach
"Examination of GLUT1 and LDHA levels by immunoblot analysis of hypoxic U2OS cells revealed that USP52 depletion impairs the accumulation of GLUT1 and LDHA in response to hypoxia (XREF_FIG A), thus demonstrating that USP52 is required to potentiate the HIF1A mediated hypoxic response."
23398456
PAN2 affects KRT9
1 |
PAN2 binds KRT9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRT6A
1 |
PAN2 binds KRT6A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRT19
1 |
PAN2 binds KRT19. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRT18
1 |
PAN2 binds KRT18. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KRE1
1 |
KRE1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects KIF11
1 |
PAN2 binds KIF11. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects KIAA1671
1 |
PAN2 binds KIAA1671. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects KCTD5
1 |
PAN2 binds KCTD5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects IRS4
1 |
PAN2 binds IRS4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects IGKV2-40
1 |
PAN2 binds IGKV2-40. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects IGF2BP1
1 |
PAN2 binds IGF2BP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HbYX
| 1
HbYX binds PAN2. 1 / 1
| 1
reach
"Prior to elution, purified and TEV cut T20S was added to columns containing HbYX-bound PAN-2 and washed thoroughly."
39396964
PAN2 affects HSPA9
1 |
PAN2 binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSPA8
1 |
PAN2 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSPA5
1 |
PAN2 binds HSPA5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSPA1A
1 |
PAN2 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HSP90AA1
1 |
PAN2 binds HSP90AA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPU
1 |
PAN2 binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPH1
1 |
PAN2 binds HNRNPH1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPD
1 |
PAN2 binds HNRNPD. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HNRNPA2B1
1 |
PAN2 binds HNRNPA2B1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HMGA1
1 |
PAN2 binds HMGA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HELZ
1 |
HELZ binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects HEF3
1 |
PAN2 binds HEF3. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects HBB
1 |
PAN2 binds HBB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects HBA2
1 |
PAN2 binds HBA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects H4C16
1 |
PAN2 binds H4C16. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects H2BC12L
1 |
PAN2 binds H2BC12L. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects H2AZ1
1 |
PAN2 binds H2AZ1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects H1-4
1 |
PAN2 binds H1-4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects Gyf
1 |
PAN2 binds Gyf. 1 / 1
1 |
biogrid
No evidence text available
31114929
PAN2 affects Gpdh1
1 |
PAN2 binds Gpdh1. 1 / 1
1 |
biogrid
No evidence text available
14605208
PAN2 affects Gapdh2
1 |
PAN2 binds Gapdh2. 1 / 1
1 |
biogrid
No evidence text available
14605208
PAN2 affects GSPT1
1 |
GSPT1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
35271311
PAN2 affects GNG12
1 |
PAN2 binds GNG12. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GNB4
1 |
PAN2 binds GNB4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GNAI3
1 |
PAN2 binds GNAI3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects GLG1
1 |
PAN2 binds GLG1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects FUS
| 1
PAN2 binds FUS. 1 / 1
| 1
reach
"Moreover, CPSF6 and PAN2 interacted with FUS both in the presence and absence of RNase A, indicating that they form an RNA independent protein complex (XREF_FIG)."
25968143
PAN2 affects FLII
1 |
PAN2 binds FLII. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects FBL
1 |
PAN2 binds FBL. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects FARSA
1 |
PAN2 binds FARSA. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EXOSC10
| 1
PAN2 activates EXOSC10. 1 / 1
| 1
reach
"1 , oligoribonuclease, exonuclease domain of family B DNA polymerases, the Saccharomyces cerevisiae PAN2 protein, the human Exonuclease ERI1, Interferon-stimulated gene 20 kDa protein (ISG20), Exosome[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20638361
PAN2 affects ERF
1 |
ERF binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects ELOC
1 |
PAN2 binds ELOC. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects ELOB
1 |
PAN2 binds ELOB. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAN2 affects ELAVL1
1 |
PAN2 binds ELAVL1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF4ENIF1
1 |
biogrid
No evidence text available
27173435
PAN2 affects EIF3I
1 |
PAN2 binds EIF3I. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF3H
1 |
PAN2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF3G
1 |
PAN2 binds EIF3G. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EIF3B
1 |
PAN2 binds EIF3B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EFHD2
1 |
PAN2 binds EFHD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects EEF1G
1 |
PAN2 binds EEF1G. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DYNLL1
1 |
DYNLL1 binds PAN2. 1 / 1
1 |
hprd
No evidence text available
11148209
PAN2 affects DST1
1 |
DST1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects DSG2
1 |
PAN2 binds DSG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DNAJA2
1 |
PAN2 binds DNAJA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DNAJA1
1 |
PAN2 binds DNAJA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DHX9
1 |
PAN2 binds DHX9. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects DEF1
1 |
PAN2 binds DEF1. 1 / 1
1 |
biogrid
No evidence text available
18467557
PAN2 affects DDX6
1 |
DDX6 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
35271311
PAN2 affects DDI1
1 |
DDI1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects DCP2
| 1
PAN2 activates DCP2. 1 / 1
| 1
reach
"However, unlike in S. cerevisiae , Pan2-initiated deadenylation precedes Dcp2-mediated decapping to degrade PTC-containing mRNA in mammals ( Fig. 3 , box 7) [97] ."
16289965
PAN2 affects DCD1
1 |
DCD1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects DBT
| 1
PAN2 activates DBT. 1 / 1
| 1
reach
"The paN2 allows Escherichia coli to liberate the sulfur of DBT and DBTs and pBADD produces a flavin reductase."
16736591
PAN2 affects CTTN
1 |
PAN2 binds CTTN. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CTNNB1
1 |
PAN2 binds CTNNB1. 1 / 1
1 |
biogrid
No evidence text available
30323974
PAN2 affects CTNNA2
1 |
PAN2 binds CTNNA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CTF4
1 |
PAN2 binds CTF4. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects CREBBP
1 |
CREBBP binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects CORO1C
1 |
PAN2 binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects COL1A2
1 |
PAN2 binds COL1A2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CNBP
1 |
PAN2 binds CNBP. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CMR3
1 |
CMR3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
PAN2 affects CMBL
1 |
PAN2 binds CMBL. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLTC
1 |
PAN2 binds CLTC. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLTB
1 |
PAN2 binds CLTB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLTA
1 |
PAN2 binds CLTA. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLINT1
1 |
PAN2 binds CLINT1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CLIC3
1 |
CLIC3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
33961781
PAN2 affects CG16884
1 |
CG16884 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
14605208
PAN2 affects CEP170
1 |
PAN2 binds CEP170. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT6A
1 |
PAN2 binds CCT6A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT5
1 |
PAN2 binds CCT5. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT4
1 |
PAN2 binds CCT4. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT3
1 |
PAN2 binds CCT3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CCT2
1 |
PAN2 binds CCT2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CAPZB
1 |
PAN2 binds CAPZB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CAPZA1
1 |
PAN2 binds CAPZA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CALM1
1 |
PAN2 binds CALM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects CALD1
1 |
PAN2 binds CALD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects C15orf39
1 |
C15orf39 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects BOLA2B
1 |
PAN2 binds BOLA2B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects BLNK
| 1
PAN2 binds exonuclease, BLNK, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
PAN2 affects BAG2
1 |
PAN2 binds BAG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ATP6V1B2
1 |
PAN2 binds ATP6V1B2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ATP5F1A
1 |
PAN2 binds ATP5F1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ARPC1B
1 |
PAN2 binds ARPC1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ARID3A
1 |
PAN2 binds ARID3A. 1 / 1
1 |
biogrid
No evidence text available
27173435
PAN2 affects AP2A2
1 |
PAN2 binds AP2A2. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ALYREF
1 |
PAN2 binds ALYREF. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects AIMP1
1 |
PAN2 binds AIMP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ACTC1
1 |
PAN2 binds ACTC1. 1 / 1
1 |
biogrid
No evidence text available
23398456
PAN2 affects ACTB
1 |
PAN2 binds ACTB. 1 / 1
1 |
biogrid
No evidence text available
23398456
PACSIN3 affects PAN2
1 |
PAN2 binds PACSIN3. 1 / 1
1 |
biogrid
No evidence text available
23398456
PABPC1 affects PAN3
1 |
PABPC1 binds PAN2 and PAN3. 1 / 1
1 |
hprd
No evidence text available
18056425
Nuclease affects ccr4
| 1
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
Nanotubes, Carbon affects PAN2
1 |
Nanotubes, Carbon decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25554681
Nanos affects PAN2
| 1
Nanos binds PAN2. 1 / 1
| 1
reach
"Nanos interacted with NOT1, NOT2, NOT3, PAN2, and PAN3 (Figs XREF_FIG A-D and XREF_FIG G-M)."
26968986
NUP50 affects PAN2
1 |
NUP50 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
NSMCE2 affects PAN2
1 |
PAN2 binds NSMCE2. 1 / 1
1 |
biogrid
No evidence text available
23398456
NR3C1 affects PAN2
1 |
NR3C1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
NR2F2 affects PAN2
1 |
NR2F2 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
NPM1 affects PAN2
1 |
PAN2 binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
NOLC1 affects PAN2
1 |
PAN2 binds NOLC1. 1 / 1
1 |
biogrid
No evidence text available
23398456
NISCH affects PAN2
1 |
PAN2 binds NISCH. 1 / 1
1 |
biogrid
No evidence text available
27173435
NEXN affects PAN2
1 |
PAN2 binds NEXN. 1 / 1
1 |
biogrid
No evidence text available
23398456
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal activates PAN2. 1 / 1
| 1
reach
"In order to exclude USP52 knockdown promoting HIF1A depletion through alternative degradation pathways, U2OS cells depleted of USP52 were treated with the proteasome inhibitor MG132."
23398456
MYO6 affects PAN2
1 |
PAN2 binds MYO6. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO5C affects PAN2
1 |
PAN2 binds MYO5C. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO5B affects PAN2
1 |
PAN2 binds MYO5B. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO5A affects PAN2
1 |
PAN2 binds MYO5A. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO1E affects PAN2
1 |
PAN2 binds MYO1E. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO1D affects PAN2
1 |
PAN2 binds MYO1D. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO1C affects PAN2
1 |
PAN2 binds MYO1C. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO18A affects PAN2
1 |
PAN2 binds MYO18A. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYO10 affects PAN2
1 |
PAN2 binds MYO10. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYL6B affects PAN2
1 |
PAN2 binds MYL6B. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYH9 affects PAN2
1 |
PAN2 binds MYH9. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYH10 affects PAN2
1 |
PAN2 binds MYH10. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYCBP affects PAN2
1 |
PAN2 binds MYCBP. 1 / 1
1 |
biogrid
No evidence text available
23398456
MYB affects PAN2
1 |
MYB decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
MTA2 affects PAN3
| 1
MTA2 binds PAN3 and PAN2. 1 / 1
| 1
sparser
"In summary, we found that it was difficult to disrupt the Pan2–Pan3 interaction by deletion of substantial regions of ct Pan2 PID and show that a core region (residues 343–406) makes a major contribution to the association of ct Pan2 and ct Pan3."
24872509
MT1M affects PAN2
1 |
PAN2 binds MT1M. 1 / 1
1 |
biogrid
No evidence text available
23398456
MRPL10 affects PAN2
1 |
MRPL10 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
MIA affects PAN2
| 1
PAN2 binds MIA. 1 / 1
| 1
sparser
"Increased expressions of PPARA1, ACAA1, FABP1, and FABP2 were detected in SNU-478 ampullary cancer cells compared to pancreatic cancer cells (Pan1 and MIA-Pan2) and gastric cancer cells (AGS) by qPCR ( xref A-D)."
33390794
MEX3C affects PAN2
1 |
MEX3C binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
26471122
MEX3A affects PAN2
1 |
MEX3A binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
36112059
MECP2 affects PAN2
1 |
MECP2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
38697112
MCM2 affects PAN2
1 |
MCM2 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
MARF1 affects PAN3
| 1
MARF1 binds PAN2 and PAN3. 1 / 1
| 1
sparser
"Next, we tested whether MARF1 binds Pan2 and Pan3, components of the Pan2–Pan3 deadenylase complex, and found that they did not co-immunoprecipitate with MARF1 (Supplementary Fig.  xref , D)."
30279526
MAP1B affects PAN2
1 |
PAN2 binds MAP1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
Lipopolysaccharides increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
25613284
Lcp65Ag3 affects PAN2
1 |
Lcp65Ag3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
14605208
LYN affects PAN2
1 |
PAN2 binds LYN. 1 / 1
1 |
biogrid
No evidence text available
23398456
LSM1 affects PAN2
1 |
PAN2 binds LSM1. 1 / 1
1 |
biogrid
No evidence text available
27173435
LMNB2 affects PAN2
1 |
PAN2 binds LMNB2. 1 / 1
1 |
biogrid
No evidence text available
23398456
LIMA1 affects PAN2
1 |
PAN2 binds LIMA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
LGALS8 affects PAN2
1 |
PAN2 binds LGALS8. 1 / 1
1 |
biogrid
No evidence text available
23398456
L-thyroxine affects PAN2
| 1
L-thyroxine activates PAN2. 1 / 1
| 1
reach
"The PCR product from the Pan 2 reaction was treated with T4 DNA polymerase (Pharmacia) to blunt the ends, and then digested with BamHl."
8124711
KRT9 affects PAN2
1 |
PAN2 binds KRT9. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRT6A affects PAN2
1 |
PAN2 binds KRT6A. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRT19 affects PAN2
1 |
PAN2 binds KRT19. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRT18 affects PAN2
1 |
PAN2 binds KRT18. 1 / 1
1 |
biogrid
No evidence text available
23398456
KRE1 affects PAN2
1 |
KRE1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
KIF11 affects PAN2
1 |
PAN2 binds KIF11. 1 / 1
1 |
biogrid
No evidence text available
23398456
KIAA1671 affects PAN2
1 |
PAN2 binds KIAA1671. 1 / 1
1 |
biogrid
No evidence text available
27173435
KCTD5 affects PAN2
1 |
PAN2 binds KCTD5. 1 / 1
1 |
biogrid
No evidence text available
23398456
IRS4 affects PAN2
1 |
PAN2 binds IRS4. 1 / 1
1 |
biogrid
No evidence text available
23398456
IGKV2-40 affects PAN2
1 |
PAN2 binds IGKV2-40. 1 / 1
1 |
biogrid
No evidence text available
23398456
IGF2BP1 affects PAN2
1 |
PAN2 binds IGF2BP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HbYX affects PAN2
| 1
HbYX binds PAN2. 1 / 1
| 1
reach
"Prior to elution, purified and TEV cut T20S was added to columns containing HbYX-bound PAN-2 and washed thoroughly."
39396964
HSPA9 affects PAN2
1 |
PAN2 binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSPA8 affects PAN2
1 |
PAN2 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSPA5 affects PAN2
1 |
PAN2 binds HSPA5. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSPA1A affects PAN2
1 |
PAN2 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
HSP90AA1 affects PAN2
1 |
PAN2 binds HSP90AA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPU affects PAN2
1 |
PAN2 binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPH1 affects PAN2
1 |
PAN2 binds HNRNPH1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPD affects PAN2
1 |
PAN2 binds HNRNPD. 1 / 1
1 |
biogrid
No evidence text available
23398456
HNRNPA2B1 affects PAN2
1 |
PAN2 binds HNRNPA2B1. 1 / 1
1 |
biogrid
No evidence text available
23398456
HELZ affects PAN2
1 |
HELZ binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
HEF3 affects PAN2
1 |
PAN2 binds HEF3. 1 / 1
1 |
biogrid
No evidence text available
37968396
HBB affects PAN2
1 |
PAN2 binds HBB. 1 / 1
1 |
biogrid
No evidence text available
23398456
HBA2 affects PAN2
1 |
PAN2 binds HBA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
HAND1 affects PAN2
1 |
HAND1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
H4C16 affects PAN2
1 |
PAN2 binds H4C16. 1 / 1
1 |
biogrid
No evidence text available
23398456
H2BC12L affects PAN2
1 |
PAN2 binds H2BC12L. 1 / 1
1 |
biogrid
No evidence text available
23398456
H2AZ1 affects PAN2
1 |
PAN2 binds H2AZ1. 1 / 1
1 |
biogrid
No evidence text available
23398456
H1-4 affects PAN2
1 |
PAN2 binds H1-4. 1 / 1
1 |
biogrid
No evidence text available
23398456
Gyf affects PAN2
1 |
PAN2 binds Gyf. 1 / 1
1 |
biogrid
No evidence text available
31114929
Gpdh1 affects PAN2
1 |
PAN2 binds Gpdh1. 1 / 1
1 |
biogrid
No evidence text available
14605208
Gapdh2 affects PAN2
1 |
PAN2 binds Gapdh2. 1 / 1
1 |
biogrid
No evidence text available
14605208
GSPT1 affects PAN2
1 |
GSPT1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
35271311
GNG12 affects PAN2
1 |
PAN2 binds GNG12. 1 / 1
1 |
biogrid
No evidence text available
23398456
GNB4 affects PAN2
1 |
PAN2 binds GNB4. 1 / 1
1 |
biogrid
No evidence text available
23398456
GNAI3 affects PAN2
1 |
PAN2 binds GNAI3. 1 / 1
1 |
biogrid
No evidence text available
23398456
GLG1 affects PAN2
1 |
PAN2 binds GLG1. 1 / 1
1 |
biogrid
No evidence text available
23398456
GATA1 affects PAN2
1 |
GATA1 decreases the amount of PAN2. 1 / 1
1 |
biopax:msigdb
No evidence text available
FR900359 affects PAN2
1 |
FR900359 dephosphorylates PAN2. 1 / 1
1 |
ctd
No evidence text available
37730182
FLII affects PAN2
1 |
PAN2 binds FLII. 1 / 1
1 |
biogrid
No evidence text available
23398456
FBL affects PAN2
1 |
PAN2 binds FBL. 1 / 1
1 |
biogrid
No evidence text available
23398456
FARSA affects PAN2
1 |
PAN2 binds FARSA. 1 / 1
1 |
biogrid
No evidence text available
23398456
ERF affects PAN2
1 |
ERF binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
ELOC affects PAN2
1 |
PAN2 binds ELOC. 1 / 1
1 |
biogrid
No evidence text available
19615732
ELOB affects PAN2
1 |
PAN2 binds ELOB. 1 / 1
1 |
biogrid
No evidence text available
19615732
ELAVL1 affects PAN2
1 |
PAN2 binds ELAVL1. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF4ENIF1 affects PAN2
1 |
biogrid
No evidence text available
27173435
EIF3I affects PAN2
1 |
PAN2 binds EIF3I. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3H affects PAN2
1 |
PAN2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3G affects PAN2
1 |
PAN2 binds EIF3G. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3B affects PAN2
1 |
PAN2 binds EIF3B. 1 / 1
1 |
biogrid
No evidence text available
23398456
EFHD2 affects PAN2
1 |
PAN2 binds EFHD2. 1 / 1
1 |
biogrid
No evidence text available
23398456
EEF1G affects PAN2
1 |
PAN2 binds EEF1G. 1 / 1
1 |
biogrid
No evidence text available
23398456
DYNLL1 affects PAN2
1 |
DYNLL1 binds PAN2. 1 / 1
1 |
hprd
No evidence text available
11148209
DST1 affects PAN2
1 |
DST1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
DSG2 affects PAN2
1 |
PAN2 binds DSG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
DNAJA2 affects PAN2
1 |
PAN2 binds DNAJA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
DNAJA1 affects PAN2
1 |
PAN2 binds DNAJA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
DHX9 affects PAN2
1 |
PAN2 binds DHX9. 1 / 1
1 |
biogrid
No evidence text available
23398456
DHUs poly A tail affects PAN2
| 1
DHUs poly A tail inhibits PAN2. 1 / 1
| 1
eidos
"The introduction of two DHUs into a poly ( A ) tail strongly inhibits Pan2 activity relative to two uracils , which only cause a slight stall in deadenylation ( Fig. 4C ; Tang et al. 2019 ) ."
32295929
DEF1 affects PAN2
1 |
PAN2 binds DEF1. 1 / 1
1 |
biogrid
No evidence text available
18467557
DDX6 affects PAN2
1 |
DDX6 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
35271311
DDI1 affects PAN2
1 |
DDI1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
DCD1 affects PAN2
1 |
DCD1 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
CTTN affects PAN2
1 |
PAN2 binds CTTN. 1 / 1
1 |
biogrid
No evidence text available
23398456
CTNNB1 affects PAN2
1 |
PAN2 binds CTNNB1. 1 / 1
1 |
biogrid
No evidence text available
30323974
CTNNA2 affects PAN2
1 |
PAN2 binds CTNNA2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CTF4 affects PAN2
1 |
PAN2 binds CTF4. 1 / 1
1 |
biogrid
No evidence text available
37968396
CREBBP affects PAN2
1 |
CREBBP binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
CORO1C affects PAN2
1 |
PAN2 binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
23398456
COL1A2 affects PAN2
1 |
PAN2 binds COL1A2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CNOT7 affects Nuclease, PAN2, PAN3, and ccr4
| 1
PAN3 binds PAN2, CNOT7, ccr4, and Nuclease. 1 / 1
| 1
sparser
"Collectively, our data support that Pan2–Pan3 and Ccr4–Caf1 poly(A) nuclease complexes can associate with each other to form a supercomplex in vivo."
18625844
CNBP affects PAN2
1 |
PAN2 binds CNBP. 1 / 1
1 |
biogrid
No evidence text available
23398456
CMR3 affects PAN2
1 |
CMR3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
37968396
CMBL affects PAN2
1 |
PAN2 binds CMBL. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLTC affects PAN2
1 |
PAN2 binds CLTC. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLTB affects PAN2
1 |
PAN2 binds CLTB. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLTA affects PAN2
1 |
PAN2 binds CLTA. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLINT1 affects PAN2
1 |
PAN2 binds CLINT1. 1 / 1
1 |
biogrid
No evidence text available
23398456
CLIC3 affects PAN2
1 |
CLIC3 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
33961781
CG16884 affects PAN2
1 |
CG16884 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
14605208
CEP170 affects PAN2
1 |
PAN2 binds CEP170. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT6A affects PAN2
1 |
PAN2 binds CCT6A. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT5 affects PAN2
1 |
PAN2 binds CCT5. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT4 affects PAN2
1 |
PAN2 binds CCT4. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT3 affects PAN2
1 |
PAN2 binds CCT3. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCT2 affects PAN2
1 |
PAN2 binds CCT2. 1 / 1
1 |
biogrid
No evidence text available
23398456
CCR4 affects PAN2
1 |
CCR4 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
29158339
CAPZB affects PAN2
1 |
PAN2 binds CAPZB. 1 / 1
1 |
biogrid
No evidence text available
23398456
CAPZA1 affects PAN2
1 |
PAN2 binds CAPZA1. 1 / 1
1 |
biogrid
No evidence text available
23398456
CALM1 affects PAN2
1 |
PAN2 binds CALM1. 1 / 1
1 |
biogrid
No evidence text available
23398456
CALD1 affects PAN2
1 |
PAN2 binds CALD1. 1 / 1
1 |
biogrid
No evidence text available
23398456
C15orf39 affects PAN2
1 |
C15orf39 binds PAN2. 1 / 1
1 |
biogrid
No evidence text available
27173435
BOLA2B affects PAN2
1 |
PAN2 binds BOLA2B. 1 / 1
1 |
biogrid
No evidence text available
23398456
BLNK affects exonuclease
| 1
PAN2 binds exonuclease, BLNK, and ccr4. 1 / 1
| 1
sparser
"Caf1 is a DEDD-family exonuclease in the Ccr4–Not complex with structural homology with the Pan2 exonuclease domain."
32295929
BAG2 affects PAN2
1 |
PAN2 binds BAG2. 1 / 1
1 |
biogrid
No evidence text available
23398456
Aroclor 1254 affects PAN2
1 |
Aroclor 1254 decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
23650126
ATP6V1B2 affects PAN2
1 |
PAN2 binds ATP6V1B2. 1 / 1
1 |
biogrid
No evidence text available
23398456
ATP5F1A affects PAN2
1 |
PAN2 binds ATP5F1A. 1 / 1
1 |
biogrid
No evidence text available
23398456
ARPC1B affects PAN2
1 |
PAN2 binds ARPC1B. 1 / 1
1 |
biogrid
No evidence text available
23398456
ARID3A affects PAN2
1 |
PAN2 binds ARID3A. 1 / 1
1 |
biogrid
No evidence text available
27173435
AP2A2 affects PAN2
1 |
PAN2 binds AP2A2. 1 / 1
1 |
biogrid
No evidence text available
23398456
ALYREF affects PAN2
1 |
PAN2 binds ALYREF. 1 / 1
1 |
biogrid
No evidence text available
23398456
AIMP1 affects PAN2
1 |
PAN2 binds AIMP1. 1 / 1
1 |
biogrid
No evidence text available
23398456
ACTC1 affects PAN2
1 |
PAN2 binds ACTC1. 1 / 1
1 |
biogrid
No evidence text available
23398456
ACTB affects PAN2
1 |
PAN2 binds ACTB. 1 / 1
1 |
biogrid
No evidence text available
23398456
4-hydroxyphenyl 4-isopropoxyphenylsulfone increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
39298647
2,3,7,8-tetrachlorodibenzodioxine increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
17942748
17beta-estradiol affects PAN2
1 |
17beta-estradiol decreases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
31614463
17alpha-ethynylestradiol increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
17942748
1,2-dimethylhydrazine increases the amount of PAN2. 1 / 1
1 |
ctd
No evidence text available
22206623