IndraLab

Statements

MINDY3 affects apoptotic process
| 10
MINDY3 activates apoptotic process.
| 9
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"In the present study, our data showed that elevated CARP expression led to significantly increased apoptosis and decreased proliferation in BGC-823 cells, which suggested that CARP partly inhibits tumor progression via precise regulation of the balance of the cell growth and death."
24870804
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"Full length CARP cDNA induced weakly apoptosis in the absence of additional apoptotic signals (Figs. 5B and 6C); however, the deleted-CARP had no apoptotic activity, suggesting that intact CARD domain[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12054670
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"We therefore examined whether cellular CARP is able to induce apoptosis when over-expressed in human cells."
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"Studies on the biological function of CARP have proved that overexpression of CARP could significantly promote apoptosis in lung carcinoma A549 and human embryonic kidney HEK293s cells, and inhibit cell proliferation in lung carcinoma A549 and PG, melanoma WM451, prostate cancer PC-3 and PC-3M, liver cancer H7402, and bladder cancer BIU87 cells XREF_BIBR, suggesting that CARP is a pro apoptotic protein and has potential anti-tumor effects."
24870804
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"To determine whether over-expression of CARP alone can induce cell apoptosis, A549 cells and HEK293S cells were stably transfected with control plasmid or plasmids carrying CARP or antisense-CARP, res[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similar results were observed by MTT assay.Since over-expression of CARP induces weak apoptosis, we tested if over-expression of CARP can inhibit tumor cell line growth."
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"To determine if CARP induced apoptosis and inhibition of cell growth requires intact CARD, HEK293S cells, ECV304 cells, and A549 cells were stably transfected with CARP, CARP-MYC, deleted-CARP, antise[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The ectopic expression of CARP in H9c2 cells increased the resistance to hypoxia induced apoptosis."
15826945
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"XREF_FIG shows stable transfection of CARP induced cell apoptosis."
24870804
MINDY3 inhibits apoptotic process.
| 1
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"CARP gene silencing inhibits tumor cell survival and increases cancer cell sensitivity to the death ligand or chemotherapy induced apoptosis."
17986872
MINDY3 inhibits cell population proliferation. 6 / 6
| 6
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"We found that overexpression of CARP significantly inhibited proliferation of BGC-823 cells (XREF_FIG)."
24870804
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"Overexpression of C10ORF97 significantly suppressed human lung carcinoma A549 cell growth (proliferation and anchorage independent growth in soft agar) and motility (migration and adhesion)."
21499297
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"In the present study, our data showed that elevated CARP expression led to significantly increased apoptosis and decreased proliferation in BGC-823 cells, which suggested that CARP partly inhibits tumor progression via precise regulation of the balance of the cell growth and death."
24870804
reach
"The cell proliferation was significantly inhibited by 1.2-5 folds (P < 0.02) in seven CARP transfected tumor cell lines-lung carcinoma A549 and PG, melanoma WM451, prostate cancer PC-3 and PC-3M, liver cancer H7402, and bladder cancer BIU87."
12054670
reach
"Studies on the biological function of CARP have proved that overexpression of CARP could significantly promote apoptosis in lung carcinoma A549 and human embryonic kidney HEK293s cells, and inhibit cell proliferation in lung carcinoma A549 and PG, melanoma WM451, prostate cancer PC-3 and PC-3M, liver cancer H7402, and bladder cancer BIU87 cells XREF_BIBR, suggesting that CARP is a pro apoptotic protein and has potential anti-tumor effects."
24870804
reach
"We found that over-expression of CARP significantly inhibits proliferation of tumor cell lines examined except two breast cancer cell lines."
12054670
MINDY3 activates cell population proliferation. 1 / 1
| 1
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"As shown in Fig. 6, the cell counting results showed that over-expression of CARP or CARP-MYC significantly inhibits proliferation while antisense-CARP, blocking CARP mRNA expression, stimulates proli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12054670
MINDY3 affects CDKN1B
| 5 1
MINDY3 activates CDKN1B.
| 2 1
MINDY3 activates CDKN1B. 3 / 3
| 2 1
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"In summary (XREF_FIG), we have shown that (a) CARP is downregulated in stomach cancer tissues; (b) CARP functioned as a tumor suppressor by inducing apoptosis, and inhibiting proliferation, migration and adhesion; (c) CARP might cause G1 arrest by promoting p27 and p21 nuclei location, and inhibits cyclin-E and CDK2 activities; (d) rs2297882 in the CARP Kozak sequence is associated with the downregulation of CARP expression and with the susceptibility to stomach cancer."
24870804
sparser
"A similar tendency in the changes of these proteins expression levels were observed in A549 cells, suggesting that CARP-induced p27 activation was responsible for CARP-induced G1 arrest and blockage of the G1/S transition."
24870804
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"A similar tendency in the changes of these proteins expression levels were observed in A549 cells, suggesting that CARP induced p27 activation was responsible for CARP induced G1 arrest and blockage of the G1/S transition."
24870804
MINDY3 increases the amount of CDKN1B.
| 2
MINDY3 increases the amount of CDKN1B. 1 / 1
| 1
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"Our study results indicated that overexpression of CARP induced an increase in p27 accompanied with decreases in cyclin-E and CDK2, and the siRNA directed CARP gene silence inhibited p27 expression and unregulated the expression of cyclin-E and CDK2."
24870804
Modified MINDY3 increases the amount of CDKN1B. 1 / 1
| 1
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"In addition, overexpression of CARP induced G1 arrest, decreased the expressions of cyclin E and CDK2, and increased the expressions of p27, p53 and p21."
24870804
MINDY3 decreases the amount of CDKN1B.
| 1
Modified MINDY3 decreases the amount of CDKN1B. 1 / 1
| 1
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"In addition, overexpression of CARP induced G1 arrest, decreased the expressions of cyclin E and CDK2, and increased the expressions of p27, p53 and p21."
24870804
Valproic acid affects MINDY3
5 |
Valproic acid increases the amount of MINDY3. 5 / 5
5 |
ctd
No evidence text available
26272509
ctd
No evidence text available
29154799
ctd
No evidence text available
23179753
ctd
No evidence text available
27188386
ctd
No evidence text available
28001369
MINDY3 affects TP53
| 1 4
MINDY3 decreases the amount of TP53.
| 2
Modified MINDY3 decreases the amount of TP53. 1 / 1
| 1
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"In addition, overexpression of CARP induced G1 arrest, decreased the expressions of cyclin E and CDK2, and increased the expressions of p27, p53 and p21."
24870804
MINDY3 decreases the amount of TP53. 1 / 1
| 1
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"CARP silencing stimulates p53 expression and promotes downstream effects, including transcriptional activation and tumor suppression."
17121812
MINDY3 ubiquitinates TP53.
| 1
MINDY3 ubiquitinates TP53 phosphorylated on S20. 1 / 1
| 1
trips
"Serine 20-phosphorylated p53 is also ubiquitinated by CARPs."
17121812
MINDY3 increases the amount of TP53.
| 1
Modified MINDY3 increases the amount of TP53. 1 / 1
| 1
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"In addition, overexpression of CARP induced G1 arrest, decreased the expressions of cyclin E and CDK2, and increased the expressions of p27, p53 and p21."
24870804
MINDY3 activates TP53.
| 1
MINDY3 activates TP53. 1 / 1
| 1
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"The results of western blot analysis showed CARP induced upregulation of p53, suggesting that the accumulation of its direct targets in the nuclei, such as Bax, may contribute to the increase in apoptosis."
24870804
MINDY3 affects COPS5
1 | 1 1
COPS5 binds MINDY3. 3 / 5
1 | 1 1
sparser
"Taken together, this evidence indicates that the physical interaction between CARP and JAB1 may be partly responsible for the increased p53 accumulation in the nucleus and the subsequent upregulation of p21 expression."
24870804
biogrid
No evidence text available
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"Taken together, this evidence indicates that the physical interaction between CARP and JAB1 may be partly responsible for the increased p53 accumulation in the nucleus and the subsequent upregulation of p21 expression."
24870804
MINDY3 affects cell adhesion
| 2 2
MINDY3 inhibits cell adhesion. 4 / 4
| 2 2
sparser
"Next, we also demonstrated that overexpressed CARP dramatically inhibited the adhesion of BGC-823 cells to artificial basement membranes."
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"Overexpression of C10ORF97 significantly suppressed human lung carcinoma A549 cell growth (proliferation and anchorage independent growth in soft agar) and motility (migration and adhesion)."
21499297
sparser
"The results of cell-matrix adhesion assay showed that CARP inhibited the adhesion to matrigel of BGC-823 cells, and the adhesion ability was decreased more than 50% ( xref )."
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"The results of cell-matrix adhesion assay showed that CARP inhibited the adhesion to matrigel of BGC-823 cells, and the adhesion ability was decreased more than 50% (XREF_FIG)."
24870804
Aflatoxin B1 affects MINDY3
3 |
Aflatoxin B1 methylates MINDY3.
2 |
Aflatoxin B1 methylates MINDY3. 2 / 2
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ctd
No evidence text available
28458013
ctd
No evidence text available
30157460
Aflatoxin B1 demethylates MINDY3.
1 |
Aflatoxin B1 demethylates MINDY3. 1 / 1
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ctd
No evidence text available
27153756
SMURF1 affects MINDY3
1 2 |
SMURF1 ubiquitinates MINDY3.
2 |
SMURF1 ubiquitinates MINDY3. 2 / 2
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ubibrowser
No evidence text available
ubibrowser
"UbiNet 2.0"
20804422
SMURF1 binds MINDY3.
1 |
SMURF1 binds MINDY3. 1 / 1
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biogrid
No evidence text available
20804422
MINDY3 affects CDKN1A
| 3
MINDY3 increases the amount of CDKN1A.
| 1
Modified MINDY3 increases the amount of CDKN1A. 1 / 1
| 1
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"In addition, overexpression of CARP induced G1 arrest, decreased the expressions of cyclin E and CDK2, and increased the expressions of p27, p53 and p21."
24870804
MINDY3 decreases the amount of CDKN1A.
| 1
Modified MINDY3 decreases the amount of CDKN1A. 1 / 1
| 1
reach
"In addition, overexpression of CARP induced G1 arrest, decreased the expressions of cyclin E and CDK2, and increased the expressions of p27, p53 and p21."
24870804
MINDY3 activates CDKN1A.
| 1
MINDY3 activates CDKN1A. 1 / 1
| 1
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"In summary (XREF_FIG), we have shown that (a) CARP is downregulated in stomach cancer tissues; (b) CARP functioned as a tumor suppressor by inducing apoptosis, and inhibiting proliferation, migration and adhesion; (c) CARP might cause G1 arrest by promoting p27 and p21 nuclei location, and inhibits cyclin-E and CDK2 activities; (d) rs2297882 in the CARP Kozak sequence is associated with the downregulation of CARP expression and with the susceptibility to stomach cancer."
24870804
MINDY3 affects CDK2
| 3
MINDY3 inhibits CDK2.
| 1
MINDY3 inhibits CDK2. 1 / 1
| 1
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"In summary (XREF_FIG), we have shown that (a) CARP is downregulated in stomach cancer tissues; (b) CARP functioned as a tumor suppressor by inducing apoptosis, and inhibiting proliferation, migration and adhesion; (c) CARP might cause G1 arrest by promoting p27 and p21 nuclei location, and inhibits cyclin-E and CDK2 activities; (d) rs2297882 in the CARP Kozak sequence is associated with the downregulation of CARP expression and with the susceptibility to stomach cancer."
24870804
MINDY3 increases the amount of CDK2.
| 1
MINDY3 increases the amount of CDK2. 1 / 1
| 1
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"Our study results indicated that overexpression of CARP induced an increase in p27 accompanied with decreases in cyclin-E and CDK2, and the siRNA directed CARP gene silence inhibited p27 expression and unregulated the expression of cyclin-E and CDK2."
24870804
MINDY3 decreases the amount of CDK2.
| 1
Modified MINDY3 decreases the amount of CDK2. 1 / 1
| 1
reach
"In addition, overexpression of CARP induced G1 arrest, decreased the expressions of cyclin E and CDK2, and increased the expressions of p27, p53 and p21."
24870804
Methyl methanesulfonate increases the amount of MINDY3.
1 |
Methyl methanesulfonate increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
23649840
Methyl methanesulfonate decreases the amount of MINDY3.
1 |
Methyl methanesulfonate decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
26011545
Indometacin affects MINDY3
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Indometacin increases the amount of MINDY3. 2 / 2
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ctd
No evidence text available
28201806
ctd
No evidence text available
28628672
Cyclosporin A affects MINDY3
2 |
Cyclosporin A increases the amount of MINDY3. 2 / 2
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ctd
No evidence text available
25562108
ctd
No evidence text available
20106945
Bisphenol A affects MINDY3
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Bisphenol A methylates MINDY3.
1 |
Bisphenol A methylates MINDY3. 1 / 1
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ctd
No evidence text available
28505145
Bisphenol A increases the amount of MINDY3.
1 |
Bisphenol A increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
25181051
ZNF644 affects MINDY3
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MINDY3 binds ZNF644. 2 / 2
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biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
ZC3HC1 affects MINDY3
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MINDY3 binds ZC3HC1. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
UBB affects MINDY3
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UBB binds MINDY3. 2 / 2
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biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
SCAF8 affects MINDY3
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SCAF8 binds MINDY3. 2 / 2
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biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
RPUSD3 affects MINDY3
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MINDY3 binds RPUSD3. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
RNF25 affects MINDY3
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RNF25 binds MINDY3. 2 / 2
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biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
PKP2 affects MINDY3
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MINDY3 binds PKP2. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MPP6 affects MINDY3
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MPP6 binds MINDY3. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY3 affects cyclin-E
| 2
MINDY3 inhibits cyclin-E.
| 1
MINDY3 inhibits cyclin-E. 1 / 1
| 1
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"In summary (XREF_FIG), we have shown that (a) CARP is downregulated in stomach cancer tissues; (b) CARP functioned as a tumor suppressor by inducing apoptosis, and inhibiting proliferation, migration and adhesion; (c) CARP might cause G1 arrest by promoting p27 and p21 nuclei location, and inhibits cyclin-E and CDK2 activities; (d) rs2297882 in the CARP Kozak sequence is associated with the downregulation of CARP expression and with the susceptibility to stomach cancer."
24870804
MINDY3 increases the amount of cyclin-E.
| 1
MINDY3 increases the amount of cyclin-E. 1 / 1
| 1
reach
"Our study results indicated that overexpression of CARP induced an increase in p27 accompanied with decreases in cyclin-E and CDK2, and the siRNA directed CARP gene silence inhibited p27 expression and unregulated the expression of cyclin-E and CDK2."
24870804
MINDY3 affects ZNF644
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MINDY3 binds ZNF644. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY3 affects ZC3HC1
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MINDY3 binds ZC3HC1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY3 affects UBB
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UBB binds MINDY3. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY3 affects SCAF8
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SCAF8 binds MINDY3. 2 / 2
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biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY3 affects RPUSD3
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MINDY3 binds RPUSD3. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY3 affects RNF25
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RNF25 binds MINDY3. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY3 affects PKP2
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MINDY3 binds PKP2. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY3 affects P-53
| 2
MINDY3 ubiquitinates P-53.
| 1
MINDY3 ubiquitinates P-53. 1 / 1
| 1
trips
"CARPs physically interact with and ubiquitinate p53, targeting it for degradation in the absence of MDM2."
17121812
MINDY3 binds P-53.
| 1
MINDY3 binds P-53. 1 / 1
| 1
trips
"CARPs physically interact with and ubiquitinate p53, targeting it for degradation in the absence of MDM2."
17121812
MINDY3 affects MPP6
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MPP6 binds MINDY3. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY3 affects MCM3
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MINDY3 binds MCM3. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY3 affects LANCL2
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MINDY3 binds LANCL2. 2 / 2
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biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY3 affects KIFC1
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MINDY3 binds KIFC1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY3 affects HNRNPLL
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY3 affects CD19
2 |
CD19 binds MINDY3. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MCM3 affects MINDY3
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MINDY3 binds MCM3. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
LANCL2 affects MINDY3
2 |
MINDY3 binds LANCL2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
KIFC1 affects MINDY3
2 |
MINDY3 binds KIFC1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
HNRNPLL affects MINDY3
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
CD19 affects MINDY3
2 |
CD19 binds MINDY3. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
Aloe emodin affects MINDY3
| 2
Aloe emodin activates MINDY3. 2 / 2
| 2
reach
"Aloe-emodin induces destabilization of caspase-8 and -10-associated RING protein (CARP) mRNA, indicating that caspase-8–mediated p53-independent apoptosis in human carcinoma cells [75] and human nasopharyngeal carcinoma cells induces caspase-3, -8, and -9–mediated activation of the mitochondrial death pathway [76]."
32289000
reach
"Aloe-emodin induces destabilization of caspase-8 and -10-associated RING protein (CARP) mRNA, indicating that caspase-8emediated p53-independent apoptosis in human carcinoma cells [75] and human nasopharyngeal carcinoma cells induces caspase-3, -8, and -9emediated activation of the mitochondrial death pathway [76] ."
32289000
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of MINDY3. 2 / 2
2 |
ctd
No evidence text available
16214954
ctd
No evidence text available
21215274
Ytterbium affects MINDY3
| 1
Ytterbium binds MINDY3. 1 / 1
| 1
reach
"The binding of the paramagnetic lanthanide ion ytterbium to the calcium binding protein carp parvalbumin results in a series of 1H NMR resonances which are shifted far outside the envelope of the 1H NMR spectrum of the diamagnetic form of the protein; bound Yb3+ also induces shifts in the 13C NMR spectrum of parvalbumin and in the 113Cd NMR spectrum of cadmium substituted parvalbumin."
6626506
Withaferin A affects MINDY3
| 1
Withaferin A activates MINDY3. 1 / 1
| 1
reach
"WA treatments also stimulated expression of the cell cycle and apoptosis regulatory protein (CARP)-1/CCAR1, a novel transducer of cell growth signaling."
22912669
Troglitazone affects MINDY3
1 |
Troglitazone increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
19140230
ctd
No evidence text available
26179874
Sunitinib affects MINDY3
1 |
Sunitinib increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
31533062
Sodium arsenite affects MINDY3
1 |
Sodium arsenite increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
29361514
Progesterone affects MINDY3
1 |
Progesterone increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
23012394
Phorbol 13-acetate 12-myristate decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
25613284
Parvalbumin affects MINDY3
| 1
MINDY3 binds parvalbumin. 1 / 1
| 1
reach
"The binding of the paramagnetic lanthanide ion ytterbium to the calcium binding protein carp parvalbumin results in a series of 1H NMR resonances which are shifted far outside the envelope of the 1H NMR spectrum of the diamagnetic form of the protein; bound Yb3+ also induces shifts in the 13C NMR spectrum of parvalbumin and in the 113Cd NMR spectrum of cadmium substituted parvalbumin."
6626506
P14_3_3 affects MINDY3
| 1
trips
"CARP-1 interacts with 14-3-3 protein as well as causes reduced expression of cell cycle regulatory genes including c-Myc and cyclin B1."
12816952
Nefazodone affects MINDY3
1 |
Nefazodone decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
24136188
Ionomycin affects MINDY3
1 |
Ionomycin decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
25613284
Hsa-miR-183-5p affects MINDY3
1 |
Hsa-miR-183-5p decreases the amount of MINDY3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Gentamycin affects MINDY3
1 |
Gentamycin increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
22061828
Formaldehyde affects MINDY3
1 |
Formaldehyde increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
23649840
Flutamide affects MINDY3
1 |
Flutamide decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
24136188
Ethyl methanesulfonate increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
23649840
Dorsomorphin affects MINDY3
1 |
Dorsomorphin increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
27188386
Dibutyl phthalate increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
21266533
Dexamethasone affects MINDY3
1 |
Dexamethasone increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
28628672
Cisplatin affects MINDY3
1 |
Cisplatin increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
27392435
Chlorpyrifos affects MINDY3
1 |
Chlorpyrifos increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
21356183
Carbon nanotube affects MINDY3
1 |
Carbon nanotube increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
25554681
Atrazine affects MINDY3
1 |
Atrazine decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
22378314
Arsenite(3-) affects MINDY3
1 |
Arsenite(3-) methylates MINDY3. 1 / 1
1 |
ctd
No evidence text available
23974009
reach
"The cause of aloe emodin-mediated apoptosis has been explained to be reduced stability of CARP mRNAs and induction of ERK and caspase-8-mediated mitochondrial death pathways [53]."
35087619
Antisense-CARP affects MINDY3
| 1
Antisense-CARP decreases the amount of MINDY3. 1 / 1
| 1
reach
"As shown in Fig. 6, the cell counting results showed that over-expression of CARP or CARP-MYC significantly inhibits proliferation while antisense-CARP, blocking CARP mRNA expression, stimulates proli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12054670
ctd
No evidence text available
25560391
TTN affects MYPN
| 1
TTN binds MYPN, MINDY3, and DCM. 1 / 1
| 1
sparser
"The encoded protein CARP interacts with partners such as myopalladin or titin, previously shown to be involved in DCM."
19525294
TRIM49 affects MINDY3
1 |
TRIM49 binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
28514442
Soman affects MINDY3
1 |
Soman decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
19281266
SNP216 affects MINDY3
| 1
SNP216 decreases the amount of MINDY3. 1 / 1
| 1
reach
"SNP216 C> T (rs2297882) in the C10ORF97 Kozak sequence was identified, and allele T of SNP216 suppressed C10ORF97 expression in vitro and in vivo."
21499297
RPL8 affects MINDY3
1 |
RPL8 binds MINDY3. 1 / 1
1 |
hprd
No evidence text available
16169070
RFX3 affects MINDY3
1 |
MINDY3 binds RFX3. 1 / 1
1 |
biogrid
No evidence text available
28514442
RAD23A affects MINDY3
1 |
MINDY3 binds RAD23A. 1 / 1
1 |
biogrid
No evidence text available
25416956
PFU affects MINDY3
| 1
PFU activates MINDY3. 1 / 1
| 1
reach
"Mahoney Virus in PFU CHAT Virus in PFU produced at 40 1 113 113 113 113 113 113 113 02 203 203 203 203 203 203 0 3 X 102 3 X 103 104 3 X 104 105 3 X 105 3 X 1050 2 X 108 6 X 103 2 X 104 6 X 104 2 X 10[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14081361
P88959 affects MINDY3
1 |
MINDY3 binds P88959. 1 / 1
1 |
virhostnet
No evidence text available
25544563
P-53 affects MINDY3
| 1
MINDY3 binds P-53. 1 / 1
| 1
trips
"CARPs physically interact with and ubiquitinate p53, targeting it for degradation in the absence of MDM2."
17121812
MINDY3 is modified
1 |
MINDY3 is phosphorylated on S125. 1 / 1
1 |
hprd
No evidence text available
18669648
NTHL1 affects MINDY3
1 |
MINDY3 binds NTHL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
N-nitrosodimethylamine increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
25380136
MYPN affects TTN
| 1
TTN binds MYPN, MINDY3, and DCM. 1 / 1
| 1
sparser
"The encoded protein CARP interacts with partners such as myopalladin or titin, previously shown to be involved in DCM."
19525294
MOS affects MINDY3
1 |
MINDY3 binds MOS. 1 / 1
1 |
biogrid
No evidence text available
28514442
MINDY3 affects ytterbium
| 1
Ytterbium binds MINDY3. 1 / 1
| 1
reach
"The binding of the paramagnetic lanthanide ion ytterbium to the calcium binding protein carp parvalbumin results in a series of 1H NMR resonances which are shifted far outside the envelope of the 1H NMR spectrum of the diamagnetic form of the protein; bound Yb3+ also induces shifts in the 13C NMR spectrum of parvalbumin and in the 113Cd NMR spectrum of cadmium substituted parvalbumin."
6626506
MINDY3 affects parvalbumin
| 1
MINDY3 binds parvalbumin. 1 / 1
| 1
reach
"The binding of the paramagnetic lanthanide ion ytterbium to the calcium binding protein carp parvalbumin results in a series of 1H NMR resonances which are shifted far outside the envelope of the 1H NMR spectrum of the diamagnetic form of the protein; bound Yb3+ also induces shifts in the 13C NMR spectrum of parvalbumin and in the 113Cd NMR spectrum of cadmium substituted parvalbumin."
6626506
MINDY3 affects p14_3_3
| 1
trips
"CARP-1 interacts with 14-3-3 protein as well as causes reduced expression of cell cycle regulatory genes including c-Myc and cyclin B1."
12816952
MINDY3 affects growth
| 1
MINDY3 inhibits growth. 1 / 1
| 1
sparser
"CARP inhibited tumor growth of BGC-823 cells in vivo ."
24870804
MINDY3 affects cell growth
| 1
MINDY3 inhibits cell growth. 1 / 1
| 1
reach
"Overexpression of C10ORF97 significantly suppressed human lung carcinoma A549 cell growth (proliferation and anchorage independent growth in soft agar) and motility (migration and adhesion)."
21499297
MINDY3 affects cell cycle
| 1
MINDY3 activates cell cycle. 1 / 1
| 1
reach
"CARP modulated the cell cycle and the expression of several cell-cycle regulators."
24870804
reach
"CARP-mediated regulations, identified so far, reflects the mechanistic diversity of cAMP signaling."
36941487
MINDY3 affects bortezomib
| 1
MINDY3 activates bortezomib. 1 / 1
| 1
reach
"Since, CCAR1 and CARP -1 is an emerging and novel target of diverse cell growth and apoptosis signaling pathways [XREF_BIBR, XREF_BIBR - XREF_BIBR] and is not involved in cisplatin dependent HBC growth inhibition [XREF_BIBR], our identification of novel Velcade targets such as CCAR1 and CARP -1 has potential to allow for design of effective anti-MPM strategies for optimizing Velcade utility in a range of MPM including the drug (Cisplatin)-resistant phenotype."
19960346
MINDY3 affects WM451
| 1
MINDY3 inhibits WM451. 1 / 1
| 1
reach
"Studies on the biological function of CARP have proved that overexpression of CARP could significantly promote apoptosis in lung carcinoma A549 and human embryonic kidney HEK293s cells, and inhibit cell proliferation in lung carcinoma A549 and PG, melanoma WM451, prostate cancer PC-3 and PC-3M, liver cancer H7402, and bladder cancer BIU87 cells XREF_BIBR, suggesting that CARP is a pro apoptotic protein and has potential anti-tumor effects."
24870804
MINDY3 affects TTN
| 1
TTN binds MYPN, MINDY3, and DCM. 1 / 1
| 1
sparser
"The encoded protein CARP interacts with partners such as myopalladin or titin, previously shown to be involved in DCM."
19525294
MINDY3 affects TRIM49
1 |
TRIM49 binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
28514442
MINDY3 affects SMURF1
1 |
SMURF1 binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
20804422
MINDY3 affects RPL8
1 |
RPL8 binds MINDY3. 1 / 1
1 |
hprd
No evidence text available
16169070
MINDY3 affects RFX3
1 |
MINDY3 binds RFX3. 1 / 1
1 |
biogrid
No evidence text available
28514442
MINDY3 affects RAD23A
1 |
MINDY3 binds RAD23A. 1 / 1
1 |
biogrid
No evidence text available
25416956
MINDY3 affects P88959
1 |
MINDY3 binds P88959. 1 / 1
1 |
virhostnet
No evidence text available
25544563
MINDY3 activates Neoplasm Invasiveness. 1 / 1
| 1
reach
"Taken together, these findings strongly support that CARP suppresses tumor progression by decreasing the invasion and metastatic abilities of tumor cells."
24870804
MINDY3 affects NTHL1
1 |
MINDY3 binds NTHL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
MINDY3 affects MYPN
| 1
TTN binds MYPN, MINDY3, and DCM. 1 / 1
| 1
sparser
"The encoded protein CARP interacts with partners such as myopalladin or titin, previously shown to be involved in DCM."
19525294
MINDY3 affects MOS
1 |
MINDY3 binds MOS. 1 / 1
1 |
biogrid
No evidence text available
28514442
MINDY3 affects MCM5
1 |
MINDY3 binds MCM5. 1 / 1
1 |
biogrid
No evidence text available
26186194
MINDY3 affects MAP3K1
1 |
MINDY3 binds MAP3K1. 1 / 1
1 |
biogrid
No evidence text available
25260751
MINDY3 affects LIN7A
1 |
LIN7A binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
26186194
MINDY3 affects L-prolylglycine
| 1
MINDY3 inhibits L-prolylglycine. 1 / 1
| 1
reach
"Studies on the biological function of CARP have proved that overexpression of CARP could significantly promote apoptosis in lung carcinoma A549 and human embryonic kidney HEK293s cells, and inhibit cell proliferation in lung carcinoma A549 and PG, melanoma WM451, prostate cancer PC-3 and PC-3M, liver cancer H7402, and bladder cancer BIU87 cells XREF_BIBR, suggesting that CARP is a pro apoptotic protein and has potential anti-tumor effects."
24870804
MINDY3 affects KIF9
1 |
KIF9 binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
28514442
MINDY3 affects KCTD10
1 |
KCTD10 binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
28514442
MINDY3 affects IBA57
1 |
MINDY3 binds IBA57. 1 / 1
1 |
biogrid
No evidence text available
26186194
MINDY3 affects HHV8GK18_gp78
1 |
MINDY3 binds HHV8GK18_gp78. 1 / 1
1 |
biogrid
No evidence text available
25544563
MINDY3 affects E7
1 |
MINDY3 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
22898364
MINDY3 affects DOK2
1 |
MINDY3 binds DOK2. 1 / 1
1 |
biogrid
No evidence text available
28514442
MINDY3 affects DCM
| 1
TTN binds MYPN, MINDY3, and DCM. 1 / 1
| 1
sparser
"The encoded protein CARP interacts with partners such as myopalladin or titin, previously shown to be involved in DCM."
19525294
MINDY3 affects Cyclin_E
| 1
Modified MINDY3 decreases the amount of Cyclin_E. 1 / 1
| 1
reach
"In addition, overexpression of CARP induced G1 arrest, decreased the expressions of cyclin E and CDK2, and increased the expressions of p27, p53 and p21."
24870804
MINDY3 affects Cell Survival
| 1
reach
"CARP gene silencing inhibits tumor cell survival and increases cancer cell sensitivity to the death ligand or chemotherapy induced apoptosis."
17986872
MINDY3 affects CSK
1 |
MINDY3 binds CSK. 1 / 1
1 |
biogrid
No evidence text available
26186194
MINDY3 affects CASP8
| 1
MINDY3 inhibits CASP8. 1 / 1
| 1
reach
"Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels."
15790545
MEIS1 affects MINDY3
1 |
MEIS1 decreases the amount of MINDY3. 1 / 1
1 |
biopax:msigdb
No evidence text available
MCM5 affects MINDY3
1 |
MINDY3 binds MCM5. 1 / 1
1 |
biogrid
No evidence text available
26186194
MAP3K1 affects MINDY3
1 |
MINDY3 binds MAP3K1. 1 / 1
1 |
biogrid
No evidence text available
25260751
LIN7A affects MINDY3
1 |
LIN7A binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
26186194
KIF9 affects MINDY3
1 |
KIF9 binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
28514442
KCTD10 affects MINDY3
1 |
KCTD10 binds MINDY3. 1 / 1
1 |
biogrid
No evidence text available
28514442
K 7174 affects MINDY3
1 |
K 7174 increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
24086573
IBA57 affects MINDY3
1 |
MINDY3 binds IBA57. 1 / 1
1 |
biogrid
No evidence text available
26186194
HHV8GK18_gp78 affects MINDY3
1 |
MINDY3 binds HHV8GK18_gp78. 1 / 1
1 |
biogrid
No evidence text available
25544563
ELK1 affects MINDY3
1 |
ELK1 decreases the amount of MINDY3. 1 / 1
1 |
biopax:msigdb
No evidence text available
E7 affects MINDY3
1 |
MINDY3 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
22898364
DOK2 affects MINDY3
1 |
MINDY3 binds DOK2. 1 / 1
1 |
biogrid
No evidence text available
28514442
DCM affects TTN
| 1
TTN binds MYPN, MINDY3, and DCM. 1 / 1
| 1
sparser
"The encoded protein CARP interacts with partners such as myopalladin or titin, previously shown to be involved in DCM."
19525294
CSK affects MINDY3
1 |
MINDY3 binds CSK. 1 / 1
1 |
biogrid
No evidence text available
26186194
COMMD4 affects ENO1, ENO3, MINDY3, PDE4DIP, and Troponin_I
| 1
Troponin_I binds PDE4DIP, MINDY3, COMMD4, ENO1, and ENO3. 1 / 1
| 1
sparser
"Thus, Western blot analysis data supported the proposed interaction of MMGL with ENO1, ENO3, CARP, cTNI and COMMD4."
21569246
CHAT affects MINDY3
| 1
CHAT activates MINDY3. 1 / 1
| 1
reach
"Mahoney Virus in PFU CHAT Virus in PFU produced at 40 1 113 113 113 113 113 113 113 02 203 203 203 203 203 203 0 3 X 102 3 X 103 104 3 X 104 105 3 X 105 3 X 1050 2 X 108 6 X 103 2 X 104 6 X 104 2 X 10[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14081361
CARP Tg affects MINDY3
| 1
CARP Tg activates MINDY3. 1 / 1
| 1
reach
"Transgenic mice that selectively overexpressed CARP in heart (CARP Tg) exhibited dilated cardiac chambers, impaired heart function, and cardiac fibrosis as assessed by echocardiography and histological staining."
33734499
3-isobutyl-1-methyl-7H-xanthine increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
28628672
2-hydroxypropanoic acid decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
30851411
17alpha-ethynylestradiol decreases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
23129252
1-naphthyl isothiocyanate increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
25380136
4,4'-sulfonyldiphenol increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
28628672
4,4'-diaminodiphenylmethane increases the amount of MINDY3. 1 / 1
1 |
ctd
No evidence text available
25380136