IndraLab

Statements

EIF3F is modified
3 | 96 17
EIF3F is phosphorylated.
3 | 93 17
EIF3F is phosphorylated. 10 / 95
| 81 14
rlimsp
"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase-processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [39] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation (Fig. 2)."
23354061
rlimsp
"The phosphorylation status of eIF3f can significantly influence its association with the eIF3 core complex and its function in the regulation of translation and apoptosis [60]."
23354061
sparser
"The 47kDa protein was phosphorylated, but there was no direct evidence that this 47kDa protein was p47phox indeed."
7658912
rlimsp
"We identified the phosphorylation sites in eIF3F responsible for M phase-specific translational repression by CDK11/p58."
32030451
sparser
"Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
sparser
"Thus, eIF3F(A3A4) was phosphorylated by CDK11/p46, demonstrating that Thr255 and Ser258 are not targeted by CDK11/p46."
32030451
sparser
"Phosphorylated eIF3f was separated from un-phosphorylated eIF3f by different pI."
19245811
sparser
"During apoptosis, phosphorylated eIF3f is significantly increased to 52% of total eIF3f."
19245811
sparser
"A proteome analysis of cell cycle-dependent phosphorylation revealed that two residues in eIF3F (Thr255 and Ser258) are specifically phosphorylated during M phase even though the kinase responsible for their phosphorylation is unknown [ xref ]."
32030451
sparser
"We next investigated the effect of eIF3f phosphorylation by CDK11 p46 on its association with the eIF3 core complex during apoptosis."
19245811
EIF3F is phosphorylated on T255. 6 / 6
2 | 4
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
sparser
"CDK11/p58 phosphorylates Thr255 and/or Ser258 of eIF3F."
32030451
sparser
"The data indicate that translation is globally repressed about 50% in M phase cells and that phosphorylation of Thr255 and/or Ser258 in eIF3F by CDK11/p58 plays a major role in the M phase-specific translational repression."
32030451
sparser
"We found that an isoform of CDK11 (CDK11/p58), which exists in large amounts only during M phase, inhibits cap-dependent translation through the phosphorylation of Thr255 and/or Ser258 in eIF3F, a subunit of eIF3."
32030451
sparser
"Phosphorylation of Thr255 and/or Ser258 in eIF3F by CDK11/p58 resulted in global translational repression in M phase."
32030451
EIF3F is phosphorylated on S258. 5 / 5
1 | 4
sparser
"The data indicate that translation is globally repressed about 50% in M phase cells and that phosphorylation of Thr255 and/or Ser258 in eIF3F by CDK11/p58 plays a major role in the M phase-specific translational repression."
32030451
sparser
"We found that an isoform of CDK11 (CDK11/p58), which exists in large amounts only during M phase, inhibits cap-dependent translation through the phosphorylation of Thr255 and/or Ser258 in eIF3F, a subunit of eIF3."
32030451
sparser
"Phosphorylation of Thr255 and/or Ser258 in eIF3F by CDK11/p58 resulted in global translational repression in M phase."
32030451
hprd
No evidence text available
20068231
sparser
"CDK11/p58 phosphorylates Thr255 and/or Ser258 of eIF3F."
32030451
EIF3F is phosphorylated on S46. 5 / 5
| 2 3
sparser
"Moreover, caspase-processed isoform of the cell division kinase 11 (Cdk11 p46 ) binds and phosphorylates eIF3f at Ser-46 and Thr-119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation ( xref )."
23769948
sparser
"For instance, phosphorylation of eIF3f at Ser46 and Thr119 was shown to enhance its association with the core eIF3 subunits leading to the inhibition of translation during apoptosis [ xref ]."
30401537
rlimsp
"Two different phosphorylation sites have been identified in eIF3f during apoptosis: Ser46 [39] and Thr119 [60]."
23354061
rlimsp
"Considering that the phosphorylations on Ser46 and Thr119 have been detected in cells undergoing apoptosis, it has been postulated that eIF3f may be involved in the inhibition of the protein synthesis when phosphorylated, acting as a downstream death executer."
23354061
rlimsp
"Upon apoptotic stimulation, CDK11p110 is cleaved by caspase 3 to generate a CDKp46 that interacts strongly with the Mov34 domain of eIF3f and phosphorylates it at Ser46 and Thr119."
23354061
EIF3F is phosphorylated on T119. 2 / 2
| 2
sparser
"For instance, phosphorylation of eIF3f at Ser46 and Thr119 was shown to enhance its association with the core eIF3 subunits leading to the inhibition of translation during apoptosis [ xref ]."
30401537
sparser
"Moreover, caspase-processed isoform of the cell division kinase 11 (Cdk11 p46 ) binds and phosphorylates eIF3f at Ser-46 and Thr-119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation ( xref )."
23769948
EIF3F is ubiquitinated.
| 3
EIF3F is ubiquitinated. 2 / 2
| 2
sparser
"Had the activity of MAFbx been increased, eIF3f should have been increasingly ubiquitinated and degraded at the proteasome [ xref ]."
31752260
sparser
"Hence any reports describing pathological phenotypes stemming from altered expression of these three subunits should be at least partially regarded as a failure of the dramatically compromised eIF3 complex to ensure productive general translation initiation in sick cells; like underexpression of eIF3f in gastric, melanoma and pancreatic cancers supposedly deregulating apoptosis ( xref , xref ), eIF3f ubiquitination and proteosomal degradation during muscle atrophy ( xref ), overexpression of eIF3m in human cancer cell lines and colon cancer patient tissues ( xref ), as well as overexpression of eIF3c in testicular seminoma cells ( xref )."
28981723
EIF3F is ubiquitinated on lysine. 1 / 1
| 1
sparser
"The ubiquitination of eIF3f on C-terminal lysine residues may serve two functions: addressing eIF3f degradation specifically by MAFbx during skeletal muscle atrophy and regulating the translation of specific pools of mRNAs of key sarcomeric proteins [ xref ]."
23354061
EIF3F affects apoptotic process
1 | 55
EIF3F activates apoptotic process.
1 | 44
EIF3F activates apoptotic process. 10 / 56
1 | 44
reach
"Interaction of Mss4 with eIF3F prevents the eIF3F mediated apoptosis."
22495352
reach
"EIF3f overexpression affects cell viability in alveolar A549 cancer cells and induces apoptosis."
20462454
reach
"The data also suggest that eIF3f inhibits cancer cell growth and induces apoptosis by blocking the function of sCLU, thereby suppressing the inactivation of p53 and Bax as well as the Akt and ERK pathways."
26988917
reach
"In human A549 cells, eIF3f exhibits a fluctuating expression pattern in cycling cells, with maximum expression peaks in G1/S and in G2/M; transient expression analysis showed that eIF3f deregulation compromises cell viability and induces apoptosis [XREF_BIBR]."
26497985
reach
"Another, the expression of eIF3f is downregulated in many human tumors, the overexpression of eIF3f inhibits cell proliferation, and induces apoptosis in tumor cells ( Doldan et al., 2008; Shi et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25888243
reach
"Downregulation of eIF3f expression by antisense-eIF3f markedly increased apoptosis in A549 cells."
20462454
reach
"These results clearly show that eIF3f is essential for the viability of A549 lung adenocarcinoma cells and that silencing of this gene promotes apoptosis; in agreement with this result, we found that downregulation of eIF3f expression in plant cells also induced apoptosis (unpublished data)."
20462454
reach
"We next defined the relationship among p53, p21, and Bax during eIF3f induced apoptosis."
26988917
reach
"Our data show that deregulation of eIF3f in A549 cells induce apoptosis by means of a caspase-9 independent pathway (data not shown)."
20462454
reach
"Overexpression of eIF3f induces apoptosis in pancreatic cancer cells."
17918192
EIF3F inhibits apoptotic process.
| 11
reach
"Endogenous eIF3f silencing by antisense RNA or siRNA inhibits cell growth and induces apoptosis in A549 cancer cells."
20462454
reach
"The same group found that eIF3f overexpression in cancer cells negatively regulates cell growth by affecting the translation efficiency and the activation of apoptosis."
23769948
reach
"Increased expression of eIF3f reduces cellular growth by inducing apoptosis in melanoma and pancreatic cancer cells [XREF_BIBR - XREF_BIBR]."
26988917
reach
"These results show that eIF3f silencing affects cell viability and induces apoptosis in A549 cells."
20462454
reach
"In our current study, we tested the hypothesis that eIF3f coordinates with hnRNP K to regulate rRNA degradation and that decreased eIF3f expression contributes to tumorigenesis by deregulating translation and apoptosis."
22457825
reach
"Conversely, eIF3f expression is a tumor suppressor in several cancers, including melanoma and pancreatic cancer, and overexpress eIF3f inhibits cell proliferation and induces apoptosis[ 29 ]."
33189778
reach
"EIF3f knockdown in A549 cells was shown to inhibit cell proliferation and induce apoptosis."
32440143
reach
"To examine whether eIF3f SATA mutant attenuates apoptosis in CDK11 p46 overexpressing cells, we co-transfected CDK11 p46 with wild type or mutant eIF3f followed by apoptosis assay."
19245811
reach
"As predicted, eIF3f SATA mutant did attenuate apoptosis in CDK11 p46 overexpressing cells compared to wild type eIF3f (XREF_FIG)."
19245811
reach
"Loss of eIF3f in pancreatic cancer may contribute to tumor cells ' evading apoptosis via upregulation of protein synthesis."
22457825
EIF3F affects translation
| 1 40 6
EIF3F inhibits translation.
| 1 30 6
EIF3F inhibits translation. 10 / 37
| 1 30 6
reach
"The same group found that eIF3f overexpression in cancer cells negatively regulates cell growth by affecting the translation efficiency and the activation of apoptosis."
23769948
reach
"Mechanistically, the authors found that eIF3f inhibits both cap dependent and cap independent translation and that eIF3f promotes rRNA degradation through direct interaction with heterogeneous nuclear ribonucleoprotein K."
23769948
eidos
"S-glycoprotein of SARS-CoV interacts with the eIF-3f , a subunit of the eukaryotic initiation factor 3 , which results in inhibition of protein synthesis [ 37 ] ."
33313362
reach
"17 Recent studies have shown that eIF3f might not be necessary for global translation initiation, but rather inhibits translation."
22495352
reach
"Shi et al reported that ectopic expression of eIF3f could inhibit nanos1 translation in vitro and in vivo [ 29 ]."
33189778
reach
"Quantification of luciferase mRNA by qRT-PCR demonstrated that translation of luciferase gene was not influenced by overexpression of Mss4 (XREF_FIG), indicating that Mss4 is indeed able to abolish the eIF3f mediated inhibition of translation."
22495352
reach
"Increase in MAFBX (Atrogin-1) promotes muscle atrophy by enhancing the degradation of MyoD (a key muscle transcription factor) and eIF3f (an essential activator of protein synthesis) thereby facilitating decreased protein synthesis in muscle leading to muscle atrophy (Bonaldo and Sandri, 2013; Sanchez et al., 2013)."
36685197
reach
"Overexpression of eIF3f inhibits translation and induces apoptosis in melanoma cells."
18381585
sparser
"Our data suggested that eIF3f may inhibit translation by increasing the binding to the eIF3 complex during apoptosis."
19245811
reach
"10 eIF3f belongs to the Mov34 protein family containing the MPN motif 11 and acts as a negative regulator of translation inhibiting both cap dependent and cap independent translation."
26052528
EIF3F activates translation.
| 10
EIF3F activates translation. 9 / 9
| 9
reach
"EIF3F has previously been shown to modulate RAN translation in cellular reporters (Ayhan et al., 2018)."
37352983
reach
"The eukaryotic translation initiation factor eIF3F has also been reported to modulate RAN translation [3]."
34953315
reach
"EIF3f induces apoptosis by inhibiting protein synthesis and proliferation in pancreatic cancer and melanoma cells, whereas eIF3f may act as a negative regulator of translational effects, and its low expression protects melanoma cells from apoptosis [67]."
36360287
reach
"Hence any reports describing pathological phenotypes stemming from altered expression of these three subunits should be at least partially regarded as a failure of the dramatically compromised eIF3 complex to ensure productive general translation initiation in sick cells; like underexpression of eIF3f in gastric, melanoma and pancreatic cancers supposedly deregulating apoptosis, eIF3f ubiquitination and proteosomal degradation during muscle atrophy, overexpression of eIF3m in human cancer cell lines and colon cancer patient tissues, as well as overexpression of eIF3c in testicular seminoma cells."
28981723
reach
"The protein MAFbx, also known as Atrogin-1, is involved in the degradation of major muscle proteins and has been shown to target the transcription factor MyoD and protein synthesis activator eIF3f, both of which play critical roles in muscle synthesis."
37109470
reach
"EIF3f Activates the Cap Dependent Translation in Muscle Cells."
20126553
reach
"Thus, we set out to determine whether eIF3f contribute in vivo to cap dependent translation."
20126553
reach
"As shown in XREF_FIG, eIF3f wt overexpression led to increase in translation rates in muscle cells."
20126553
reach
"For instance, eIF3f is an important housekeeping gene and is necessary for initiation of translation."
21543451
Mutated EIF3F activates translation. 1 / 1
| 1
reach
"Interestingly, overexpression of the mutant eIF3f K 5-10 R increased the cap dependent translation in the same order as observed with insulin."
20126553
S affects EIF3F
2 3 3 | 18 18
S binds EIF3F.
1 3 3 | 17 18
S binds EIF3F. 10 / 35
| 17 18
sparser
"Meanwhile, parallel experiments confirmed that eIF3f could also interact with the S protein of another coronavirus, the avian coronavirus infectious bronchitis virus (IBV)."
18231581
sparser
"Furthermore, eIF3f can also interact with the S protein of SARS-CoV and infectious bronchitis virus (IBV) to inhibit expression of host genes ( xref )."
29173589
reach
"Similar experiments were then performed to check if the full-length SARS-CoV S protein could also interact with eIF3f."
18231581
reach
"These results confirm that the full-length S protein can also interact with eIF3f."
18231581
sparser
"Interestingly, IBV-infected cells stably expressing a Flag-tagged eIF3f showed much higher translation of IL-6 and IL-8, suggesting that the interaction between coronavirus S protein and eIF3f plays a functional role in controlling the expression of host genes, especially genes that are induced during coronavirus infection cycles."
18231581
sparser
"We show here that eIF3f could interact with the S protein from two coronaviruses, SARS-CoV and the coronavirus infectious bronchitis virus (IBV)."
18231581
sparser
"Interaction of SARS-CoV S protein with eIF3f."
18231581
sparser
"Similar experiments were then performed to check if the full-length SARS-CoV S protein could also interact with eIF3f."
18231581
sparser
"The interaction between coronavirus S protein and eIF3f plays a functional role in controlling the expression of host genes, especially genes that are induced during coronavirus infection [ xref ]."
24740387
sparser
"These results confirm that the full-length S protein can also interact with eIF3f."
18231581
S binds EIF3F. 4 / 4
1 3 |
signor
"Coronavirus spike protein inhibits host cell translation by interaction with eIF3f"
18231581
biogrid
No evidence text available
18231581
biogrid
No evidence text available
18231581
biogrid
No evidence text available
18231581
EIF3F binds S. 3 / 3
3 |
virhostnet
No evidence text available
18231581
virhostnet
No evidence text available
18231581
virhostnet
No evidence text available
18231581
S inhibits EIF3F.
1 | 1
S inhibits EIF3F. 1 / 1
1 |
signor
"Coronavirus spike protein inhibits host cell translation by interaction with eIF3f"
18231581
S inhibits EIF3F. 1 / 1
| 1
reach
"The staining patterns of the two proteins are well overlapped (XREF_FIG, panel E), suggesting that the S protein may sequester the eIF3f to the cytoplasm."
18231581
EIF3F affects RPS6KB1
3 | 1 1 18 14
EIF3F binds RPS6KB1.
3 | 1 6 13
RPS6KB1 binds EIF3F. 10 / 20
3 | 1 6 10
biogrid
No evidence text available
16286006
sparser
"During terminal muscle differentiation, eIF3f interacts with hypophosphorylated S6K1 through its MPN domain and with the mTOR/Raptor complex (mTORC1) by interacting with a TOS site contained in its C-terminal region [ xref ]."
26497985
sparser
"As previously shown in xref , the non-phosphorylated form of S6K1 interacts with eIF3f."
20126553
sparser
"Inactive S6K1 is bound to eIF3f, and upon amino acid/growth factor/mitogen stimulation, mTOR binds to eIF3f, leading to the phosphorylation and activation of S6K1 ( xref , xref )."
23769948
biogrid
No evidence text available
24396066
biogrid
No evidence text available
24396066
sparser
"The Mov34 domain of eIF3f is able to associate with the hypophosphorylated form of S6K1 adds to the evidence of a physical association of eIF3f and S6K1 prior to S6K1 activation."
20126553
trips
"S6K1 interacts with eIF3f and, in vitro, phosphorylates eIF3."
24396066
reach
"During the muscle cell growth, eIF3f interacts with mTOR and S6K1 to promote the assembly of the translation initiation complex and is degraded by MAFbx."
23354061
reach
"S6K1 interacts with eIF3f and, in vitro, phosphorylates eIF3."
24396066
MTOR binds RPS6KB1 and EIF3F. 3 / 3
| 3
sparser
"MTOR and S6K1 physically interact with two different domains of eIF3f."
20126553
sparser
"Our group proposed that S6K1 and mTOR physically interact with two different domains of eIF3f in muscle cells."
23769948
sparser
"This idea is supported by studies which have shown that eIF3f physically interacts with mTOR and p70 S6K ( xref , xref )."
20154608
EIF3F activates RPS6KB1.
| 1 8
EIF3F activates RPS6KB1. 9 / 9
| 1 8
reach
"Only eIF3f with an intact TOS motif coimmunoprecipitates with mTOR-raptor (XREF_FIG) and activates mTOR-raptor and S6K1 pathway (XREF_FIG)."
20126553
reach
"Degradation of eIF3f by MAFbx Suppresses S6K1 Activation by mTOR."
20126553
reach
"The degradation of eIF3f suppresses S6K1 activation by mTOR in a MAFbx and atrogin-1-induced atrophy model."
23769948
reach
"In contrast, eIF3f knockdown was sufficient to induce the repression of S6K1 activity and the lack of myogenic differentiation (XREF_FIG)."
20126553
reach
"To further confirm that eIF3f mediates activation of S6K1 by mTOR, an eIF3f mutant deleted of the C-terminal domain was transfected in mouse primary muscle cells and the phosphorylation of downstream targets of mTOR was assessed."
20126553
eidos
"The degradation of eIF3f suppresses S6K1 activation by mTOR in a MAFbx / atrogin-1-induced atrophy model ( Csibi et al ., 2010 ) ."
23769948
reach
"Genetic repression of eIF3f in differentiated skeletal muscle is sufficient to induce atrophy XREF_BIBR and degradation of eIF3f by MAFbx suppresses S6K1 activation by mTOR."
20126553
reach
"Moreover inhibition of eIF3f degradation (mutant eIF3f K 5-10 R) in MAFbx induced atrophy maintained S6K1 activation by mTOR (XREF_FIG) and electroporation of eIF3f K 5-10 R expression vector in mice not only protects against muscle atrophy but also induces hypertrophy XREF_BIBR."
20126553
reach
"Here we present evidence that in MAFbx induced atrophy the degradation of eIF3f suppresses S6K1 activation by mTOR, whereas an eIF3f mutant insensitive to MAFbx polyubiquitination maintained persistent phosphorylation of S6K1 and rpS6."
20126553
EIF3F phosphorylates RPS6KB1.
| 2 1
EIF3F leads to the phosphorylation of RPS6KB1. 3 / 3
| 2 1
reach
"We set out to determine the functional consequences of the eIF3f induced activation of mTORC1 and phosphorylation of S6K1 and 4E-BP1 (XREF_FIG), thus we investigated the formation of the translational PIC by using a cap binding assay."
20126553
reach
"In contrast, HA tagged eIF3f mutant K 5-10 R overexpressed in mouse primary myotubes at 4 th day of differentiation was able to bind both endogenous mTOR and raptor by about 2-fold higher than HA tagged eIF3f wt leading to a higher phosphorylation and activity of S6K1 as evidenced by an increased phosphorylation of rpS6 on Ser235/236 residues (XREF_FIG)."
20126553
sparser
"Since eIF3f serves as a connecting platform between mTOR-raptor and S6K1 in muscle cells ( xref ) and mutation of the C-terminal lysines in eIF3f increases phosphorylation of S6K1, we assessed the binding affinities of both eIF3f wt and mutant eIF3f K 5–10 R proteins with S6K1 and mTOR-raptor."
20126553
EIF3F dephosphorylates RPS6KB1.
| 2
EIF3F leads to the dephosphorylation of RPS6KB1. 2 / 2
| 2
reach
"XREF_BIBR Ablation of eIF3f in muscle cells prevented mTORC1 activity, phosphorylation of p70S6K1, rpS6, 4E-BP1 and myogenic differentiation."
25486193
reach
"They also observed that rapamycin treatment destabilizes the mTORC1 and eIF3f interaction in differentiated myotubes, and that ablation of eIF3f in muscle cells prevents mTORC1 activity and phosphorylation of S6K1, rpS6 and 4E-BP1 [XREF_BIBR]."
23354061
EIF3F affects CLU
4 | 16 10
EIF3F binds CLU.
4 | 7 10
CLU binds EIF3F. 10 / 25
4 | 7 10
sparser
"In addition, eIF3F can stabilize p53 and interact with CLU protein, a secretory heterodimeric glycoprotein thus leading to cancer cell proliferation in humans functioning as a CLU inhibitor xref ."
29167521
sparser
"EIF3f interacts with CLU in the cytoplasm."
26988917
sparser
"These results suggest that eIF3f might interact with CLU protein to reduce the expression of sCLU in both intracellular and extracellular compartments by preventing structural changes."
26988917
sparser
"As shown in Figure xref , the region between amino acids 1 and 227 of CLU interacts directly with eIF3f, whereas the region between amino acids 1 and 169 of eIF3f interacts directly with CLU and was phosphorylated by CDK11p46 during apoptosis [ xref , xref ] (Figure xref )."
26988917
sparser
"The interaction between CLU and eIF3f was confirmed by growth assays and Δ-galactosidase assays using a yeast two-hybrid system."
26988917
sparser
"These results suggest that CLU can bind directly to eIF3f."
26988917
sparser
"Therefore, these results suggest that eIF3f and CLU strongly interact with each other in the cytoplasm."
26988917
sparser
"To identify the specific region responsible for the interaction between CLU and eIF3f, we generated four deletion constructs for CLU and eIF3f each and performed yeast two-hybrid assays."
26988917
reach
"These results suggest that CLU can bind directly to eIF3f."
26988917
reach
"To identify the specific region responsible for the interaction between CLU and eIF3f, we generated four deletion constructs for CLU and eIF3f each and performed yeast two-hybrid assays."
26988917
EIF3F inhibits CLU.
| 4
EIF3F inhibits CLU. 4 / 7
| 4
reach
"EIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells."
26988917
reach
"To assess how eIF3f inhibits CLU activity, we generated several deletion constructs and analyzed the specific sites responsible for the binding between eIF3f and CLU."
26988917
reach
"To assess whether the overexpression of eIF3f inhibits the function of CLU, we next measured the expression of several proteins that induce apoptosis."
26988917
reach
"Correction : eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells."
28571123
EIF3F decreases the amount of CLU.
| 4
Modified EIF3F decreases the amount of CLU. 2 / 2
| 2
reach
"Consequently, the overexpression of eIF3f suppressed Akt and ERK signaling and subsequently depleted CLU expression."
26988917
reach
"Overexpression of eIF3f was recently shown to suppress Akt and ERK signaling, increase p53 protein levels and inhibit clusterin protein expression, which promotes cancer cell proliferation and reduces chemosensitivity [XREF_BIBR]."
29153484
EIF3F decreases the amount of CLU. 2 / 2
| 2
reach
"The previous figures show that eIF3f inhibited CLU expression and induced apoptotic signal."
26988917
reach
"EIF3f transfection was observed to significantly decrease the psCLU and alpha/beta CLU expression and inhibit Akt and ERK phosphorylation."
26988917
EIF3F increases the amount of CLU.
| 1
Modified EIF3F increases the amount of CLU. 1 / 1
| 1
reach
"Overexpression of eIF3f was recently shown to suppress Akt and ERK signaling, increase p53 protein levels and inhibit clusterin protein expression, which promotes cancer cell proliferation and reduces chemosensitivity [XREF_BIBR]."
29153484
FBXO32 affects EIF3F
3 1 | 1 25 3
FBXO32 inhibits EIF3F.
| 1 12
FBXO32 inhibits EIF3F. 10 / 13
| 1 12
reach
"In addition, expression of a protein Fbxo32, which degrades MyoD and eIF3-f in skeletal muscle, was also increased in muscle of CTG550 mice."
23796888
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"Degradation of eIF3f by MAFbx Suppresses S6K1 Activation by mTOR."
20126553
reach
"The silencing of MAFbx expression by small hairpin RNA interference prevents eIF3f degradation in myotubes undergoing atrophy [XREF_BIBR]."
23354061
reach
"In addition, recent studies indicate that under atrophic conditions, atrogin-1 can directly regulate mTORC1 signalling and protein synthesis via the ubiquitination and subsequent degradation of eIF3f."
21821120
reach
"Furthermore, berberine, an inhibitor of mitochondrial respiration, induces atrophy through MAFbx and atrogin-1-mediated degradation of eIF3f in a mice model of type 2 diabetes."
23769948
reach
"Our data are consistent with a model whereby alcohol increases proteolysis via FOXO independent increase in atrogin-1, which degrades eIF3f and therefore impairs formation of a functional preinitiation complex and protein synthesis."
24226028
reach
"Moreover, atrogin-1 was recently reported to inhibit S6K1 activity via eIF3f ( Csibi et al., 2010 )."
21284984
eidos
"Of note , a subset of microRNAs ( miRNAs ) in the delta-like homolog 1 and the type III iodothyronine deiodinase ( Dlk1-Dio3 ) cluster showed an anti-atrophic effect , probably by limiting the degradation of eIF3f by MAFbx / atrogin-1 [ 168 ] ."
| PMC
reach
"MAFbx/atrogin-1 promotes degradation of MyoD ( Tintignac et al., 2005 ), a key muscle transcription factor, and eIF3-f (eukaryotic initiation factor-3f), an activator of translation initiation ( Lagir[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23916784
reach
"Genetic repression of eIF3f in differentiated skeletal muscle is sufficient to induce atrophy XREF_BIBR and degradation of eIF3f by MAFbx suppresses S6K1 activation by mTOR."
20126553
FBXO32 binds EIF3F.
3 | 2 2
FBXO32 binds EIF3F. 7 / 7
3 | 2 2
biogrid
No evidence text available
19073596
biogrid
No evidence text available
18354498
biogrid
No evidence text available
18354498
reach
"Whether MAFbx interacts with free eIF3f or with eIF3f molecules bound to S6K1 still remains unclear."
23354061
sparser
"Whether MAFbx interacts with free eIF3f or with eIF3f molecules bound to S6K1 still remains unclear."
23354061
reach
"Interestingly, eIF3-f binds MAFbx in skeletal muscle, which explains, probably, protein synthesis decrease during muscle atrophy of different nature [XREF_BIBR]."
22496611
sparser
"Muscles undergoing atrophy accumulates the inactive form of S6K1 suggesting that degradation of eIF3f mediated by MAFbx participates to S6K1 inactivation during atrophy and raises the question whether MAFbx interacts with free eIF3f molecules or bound to hypophosphorylated S6K1."
20126553
FBXO32 activates EIF3F.
| 6
FBXO32 activates EIF3F. 6 / 6
| 6
reach
"Muscles undergoing atrophy accumulates the inactive form of S6K1 suggesting that degradation of eIF3f mediated by MAFbx participates to S6K1 inactivation during atrophy and raises the question whether MAFbx interacts with free eIF3f molecules or bound to hypophosphorylated S6K1."
20126553
reach
"MAFbx has been shown to target and degrade MyoD, myogenin, and Eif3f, and degradation of any of these proteins reduces myotube diameters."
23523565
reach
"Atrogin-1 also targets myogenic differentiastion1 (MyoD) and eukaryotic initiation factor 3 subunit 5 (eIF3-f), which play key roles in the control of protein synthesis XREF_BIBR."
25032690
reach
"Ectopic expression of MAFbx in myotubes induces atrophy and degradation of eIF3-f."
18354498
reach
"It was found that the E3 ubiquitin ligase MAFbx and atrogin -1 targets the Mov34 motif of eIF3f during atrophy for polyubiquitination and subsequent degradation by the proteasome [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
| PMC
reach
"Of note, a subset of microRNAs (miRNAs) in the delta like homolog 1 and the type III iodothyronine deiodinase (Dlk1-Dio3) cluster showed an anti-atrophic effect, probably by limiting the degradation of eIF3f by MAFbx and atrogin -1 [XREF_BIBR]."
| PMC
FBXO32 ubiquitinates EIF3F.
1 | 3 1
FBXO32 ubiquitinates EIF3F. 5 / 5
1 | 3 1
sparser
"During muscle atrophy, the ubiquitin ligase MAFbx ubiquitinates eIF3f leading to its proteasomal degradation ( xref )."
21487027
ubibrowser
"E3Net"
22199232
reach
"MAFbx is known to stimulate polyubiquitination of eIF3-f with its following degradation by 26S proteasome."
22496611
reach
"During muscle atrophy, the ubiquitin ligase MAFbx ubiquitinates eIF3f leading to its proteasomal degradation."
21487027
reach
"The Mov34 motif, involved in MAFbx and atrogin-1-mediated polyubiquitination of eIF3f is responsible for the interaction with the inactive hypophosphorylated form of S6K1 (XREF_FIG)."
23769948
FBXO32 decreases the amount of EIF3F.
| 1
FBXO32 decreases the amount of EIF3F. 1 / 3
| 1
reach
"MAFbx not only directs ActRII degradation, but also the loss of eukaryotic translation initiation factor 3 subunit f (225, 226) whereas in parallel, TRIM32 targets desmin, α-actinin, filamentous actin, and plakoglobin, a desmosomal component required for PI3K activity (227, 228)."
34520530
FBXO32 increases the amount of EIF3F.
| 1
FBXO32 increases the amount of EIF3F. 1 / 1
| 1
reach
"Importantly, knockdown of atrogin-1 prevented the berberine induced decrease in eIF3f levels, protein synthesis and atrophy [XREF_BIBR]."
21821120
reach
"Another, the expression of eIF3f is downregulated in many human tumors, the overexpression of eIF3f inhibits cell proliferation, and induces apoptosis in tumor cells ( Doldan et al., 2008; Shi et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25888243
reach
"We found that ectopic expression of constitutively active Akt partially rescued the obstructed proliferation caused by eIF3f knockdown."
32440143
reach
"Overexpressing eIF3f inhibits cell proliferation and induces apoptosis."
38388452
reach
"Recent reports on the biological function of eIF3f in translation and apoptosis in tumor cells demonstrated that eIF3f is down regulated in most human tumors and that overexpression of eIF3f inhibited cell proliferation suggesting a function associated with differentiation XREF_BIBR."
20126553
reach
"Conversely, eIF3f expression is a tumor suppressor in several cancers, including melanoma and pancreatic cancer, and overexpress eIF3f inhibits cell proliferation and induces apoptosis[ 29 ]."
33189778
reach
"EIF3F overexpression induces apoptosis in pancreatic and melanoma cancer cells and disrupts the proliferation of tumor cells (32,34,35)."
35116824
reach
"MD 11 -NF, MD 11 -wt eIF3f, and MD 11 -K510R induced inhibition of cellular proliferation in all target cell lines in a dose- and a time dependent manner."
26052528
reach
"Overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells."
16532022
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR Advances in the understanding of the molecular mechanism behind cellular carcinogenesis have shown that ectopic expression of eIF3f by transient gene transfection inhibits translation, cellular growth and proliferation and induces apoptosis."
26052528
reach
"In our current study, we found evidence that stable knockdown of eIF3f in normal human pancreatic ductal epithelial cells increased cell size, nuclear pleomorphism, cytokinesis defects, cell proliferation, clonogenicity, apoptotic resistance, migration, and formation of 3-dimensional irregular masses."
22457825
eidos
"These results suggest that eIF3F modulates cell proliferation by repressing translation ."
32030451
reach
"The proliferation rates of shRNA lentivirus infected PCa cells indicated that eIF3f knockdown markedly decreased the proliferation of PCa cells (XREF_FIG)."
32440143
reach
"Furthermore, we found that ectopic expression of sheIF3f # 1 resistant wild-type eIF3f rescued the proliferation rate of eIF3f knockdown cells (XREF_FIG)."
32440143
reach
"These results indicated that eIF3f knockdown caused inhibition of PCa cell proliferation at least partially through the suppression of Akt phosphorylation."
32440143
reach
"EIF3f knockdown in A549 cells was shown to inhibit cell proliferation and induce apoptosis."
32440143
reach
"We confirmed that the loss of eIF3f reduced the proliferation of PCa cells, both in vitro and in vivo."
32440143
reach
"EIF3f induces apoptosis by inhibiting protein synthesis and proliferation in pancreatic cancer and melanoma cells, whereas eIF3f may act as a negative regulator of translational effects, and its low expression protects melanoma cells from apoptosis [67]."
36360287
EIF3H affects EIF3F
13 | 3 15
EIF3H binds EIF3F. 10 / 25
13 | 3 8
sparser
"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 ( xref )."
20068067
sparser
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
biogrid
No evidence text available
32269044
sparser
"Moreover, both eIF3f and eIF3h interact directly with each other, supporting a possible scaffolding role for these subunits ( xref )."
23769948
biogrid
No evidence text available
22939629
sparser
"xDnd1 directly binds eIF3f and in IP experiments, brings down eIF3m and eIF3h, which associate with eIF3f ( xref )."
30230100
biogrid
No evidence text available
26186194
sparser
"Our results show that At eIF3f interacts with eIF3h."
20444226
sparser
"In contrast, mammalian eIF3f interacts with eIF3h directly, and seems not indispensable for other eIF3 subunits assembly, based on previous reports ( xref ; xref )."
27932584
biogrid
No evidence text available
28514442
EIF3F binds EIF3E and EIF3H. 5 / 5
| 5
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
MTOR affects EIF3F
4 1 | 10 15
MTOR binds EIF3F.
4 1 | 8 13
EIF3F binds MTOR. 10 / 21
4 1 | 8 8
biogrid
No evidence text available
16541103
biogrid
No evidence text available
16541103
reach
"Importantly, the authors also found that the interaction between mTOR and eIF3f increased at the cell membrane after exercise and this response was enhanced in a fed state (20g protein / 40 g carbohydrate / 1 g fat) [XREF_BIBR]."
| PMC
reach
"Under normal conditions, inactive S6K1 is bound to eIF3f and, upon mitogenic stimulation, MTOR binds to eIF3f and then phosphorylates and activates S6K1 (Csibi et al. 2008)."
31026345
reach
"The proximity of S6K1 and 4E-BP1 binding sites on MTOR could allow the interaction of the latter with eIF3f and MTOR complex (Marabita et al. 2016)."
31026345
sparser
"Inactive S6K1 is bound to eIF3f, and upon amino acid/growth factor/mitogen stimulation, mTOR binds to eIF3f, leading to the phosphorylation and activation of S6K1 ( xref , xref )."
23769948
sparser
"This reduction in mammalian target of rapamycin (mTOR) kinase activity was associated with reduced eIF3f and binding of both Raptor and eIF4G to eIF3."
24226028
biogrid
No evidence text available
16541103
hprd
No evidence text available
16541103
sparser
"Indeed association of eIF3f with mTOR and its activation is correlated with S6K1 activation and its respective dissociation from eIF3f."
20126553
MTOR binds RPS6KB1 and EIF3F. 3 / 3
| 3
sparser
"MTOR and S6K1 physically interact with two different domains of eIF3f."
20126553
sparser
"Our group proposed that S6K1 and mTOR physically interact with two different domains of eIF3f in muscle cells."
23769948
sparser
"This idea is supported by studies which have shown that eIF3f physically interacts with mTOR and p70 S6K ( xref , xref )."
20154608
MTOR binds RPTOR and EIF3F. 2 / 2
| 2
sparser
"Mutation of the C-Terminal Lysines in eIF3f Increases Interaction with mTOR and Raptor."
20126553
sparser
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
MTOR phosphorylates EIF3F.
| 2 2
MTOR phosphorylates EIF3F. 4 / 4
| 2 2
sparser
"This work also showed that p70S6K1 interacts with, and phosphorylates eIF3f, leading the authors to suggest that p70S6K1 phosphorylates eIF3 to stimulate the Paip1-eIF3 interaction and promotes translation initiation. xref Whether mTOR or p70S6K directly phosphorylates eIF3f in C2C12 cells or the effects of ablation of eIF3f on differentiation are unknown at this time."
25486193
reach
"Although our preliminary data did not show major posttranslational modifications of eIF3f during muscle differentiation, it is possible that mTOR directly phosphorylates eIF3f and we are currently pursuing this line of investigation to see whether there is any mTOR dependent and rapamycin sensitive phosphorylation sites within eIF3f."
20126553
sparser
"Although our preliminary data did not show major posttranslational modifications of eIF3f during muscle differentiation, it is possible that mTOR directly phosphorylates eIF3f and we are currently pursuing this line of investigation to see whether there is any mTOR-dependent and rapamycin-sensitive phosphorylation sites within eIF3f."
20126553
reach
"XREF_BIBR Whether mTOR or p70S6K directly phosphorylates eIF3f in C2C12 cells or the effects of ablation of eIF3f on differentiation are unknown at this time."
25486193
EIF3F affects MTOR
4 1 | 10 13
EIF3F binds MTOR.
4 1 | 8 13
EIF3F binds MTOR. 10 / 21
4 1 | 8 8
biogrid
No evidence text available
16541103
biogrid
No evidence text available
16541103
reach
"Importantly, the authors also found that the interaction between mTOR and eIF3f increased at the cell membrane after exercise and this response was enhanced in a fed state (20g protein / 40 g carbohydrate / 1 g fat) [XREF_BIBR]."
| PMC
reach
"Under normal conditions, inactive S6K1 is bound to eIF3f and, upon mitogenic stimulation, MTOR binds to eIF3f and then phosphorylates and activates S6K1 (Csibi et al. 2008)."
31026345
reach
"The proximity of S6K1 and 4E-BP1 binding sites on MTOR could allow the interaction of the latter with eIF3f and MTOR complex (Marabita et al. 2016)."
31026345
sparser
"Inactive S6K1 is bound to eIF3f, and upon amino acid/growth factor/mitogen stimulation, mTOR binds to eIF3f, leading to the phosphorylation and activation of S6K1 ( xref , xref )."
23769948
sparser
"This reduction in mammalian target of rapamycin (mTOR) kinase activity was associated with reduced eIF3f and binding of both Raptor and eIF4G to eIF3."
24226028
biogrid
No evidence text available
16541103
hprd
No evidence text available
16541103
sparser
"Indeed association of eIF3f with mTOR and its activation is correlated with S6K1 activation and its respective dissociation from eIF3f."
20126553
MTOR binds RPS6KB1 and EIF3F. 3 / 3
| 3
sparser
"MTOR and S6K1 physically interact with two different domains of eIF3f."
20126553
sparser
"Our group proposed that S6K1 and mTOR physically interact with two different domains of eIF3f in muscle cells."
23769948
sparser
"This idea is supported by studies which have shown that eIF3f physically interacts with mTOR and p70 S6K ( xref , xref )."
20154608
MTOR binds RPTOR and EIF3F. 2 / 2
| 2
sparser
"Mutation of the C-Terminal Lysines in eIF3f Increases Interaction with mTOR and Raptor."
20126553
sparser
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
EIF3F activates MTOR.
| 2
EIF3F activates MTOR. 2 / 2
| 2
reach
"Deletion of the C-terminus of eIF3f has been shown to repress mTOR activity in muscle cells (XREF_FIG)."
20126553
reach
"It has been previously shown that degradation of eIF3f suppresses p70S6k activation via mTOR whereas an eIF3f mutant insensitive to MAFbx/atrogin-1 polyubiquitination maintains persistent phosphorylat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35947892
RPS6KB1 affects EIF3F
3 | 1 8 14
RPS6KB1 binds EIF3F.
3 | 1 6 13
RPS6KB1 binds EIF3F. 10 / 20
3 | 1 6 10
biogrid
No evidence text available
16286006
sparser
"During terminal muscle differentiation, eIF3f interacts with hypophosphorylated S6K1 through its MPN domain and with the mTOR/Raptor complex (mTORC1) by interacting with a TOS site contained in its C-terminal region [ xref ]."
26497985
sparser
"As previously shown in xref , the non-phosphorylated form of S6K1 interacts with eIF3f."
20126553
sparser
"Inactive S6K1 is bound to eIF3f, and upon amino acid/growth factor/mitogen stimulation, mTOR binds to eIF3f, leading to the phosphorylation and activation of S6K1 ( xref , xref )."
23769948
biogrid
No evidence text available
24396066
biogrid
No evidence text available
24396066
sparser
"The Mov34 domain of eIF3f is able to associate with the hypophosphorylated form of S6K1 adds to the evidence of a physical association of eIF3f and S6K1 prior to S6K1 activation."
20126553
trips
"S6K1 interacts with eIF3f and, in vitro, phosphorylates eIF3."
24396066
reach
"During the muscle cell growth, eIF3f interacts with mTOR and S6K1 to promote the assembly of the translation initiation complex and is degraded by MAFbx."
23354061
reach
"S6K1 interacts with eIF3f and, in vitro, phosphorylates eIF3."
24396066
MTOR binds RPS6KB1 and EIF3F. 3 / 3
| 3
sparser
"MTOR and S6K1 physically interact with two different domains of eIF3f."
20126553
sparser
"Our group proposed that S6K1 and mTOR physically interact with two different domains of eIF3f in muscle cells."
23769948
sparser
"This idea is supported by studies which have shown that eIF3f physically interacts with mTOR and p70 S6K ( xref , xref )."
20154608
RPS6KB1 phosphorylates EIF3F.
| 2 1
RPS6KB1 phosphorylates EIF3F. 3 / 3
| 2 1
sparser
"This work also showed that p70S6K1 interacts with, and phosphorylates eIF3f, leading the authors to suggest that p70S6K1 phosphorylates eIF3 to stimulate the Paip1-eIF3 interaction and promotes translation initiation. xref Whether mTOR or p70S6K directly phosphorylates eIF3f in C2C12 cells or the effects of ablation of eIF3f on differentiation are unknown at this time."
25486193
reach
"XREF_BIBR Whether mTOR or p70S6K directly phosphorylates eIF3f in C2C12 cells or the effects of ablation of eIF3f on differentiation are unknown at this time."
25486193
reach
"This work also showed that p70S6K1 interacts with, and phosphorylates eIF3f, leading the authors to suggest that p70S6K1 phosphorylates eIF3 to stimulate the Paip1-eIF3 interaction and promotes translation initiation."
25486193
MSH4 affects EIF3F
5 | 12 1
MSH4 binds EIF3F.
5 | 10 1
MSH4 binds EIF3F. 10 / 21
5 | 10 1
reach
"To further validate the existence of a direct physical interaction between hMSH4 and eIF3f, we next performed a GST pull-down analysis of recombinant His 6 -hMSH4 and GST-eIF3f proteins."
23725059
reach
"EIF3f also binds to the stress-stimulated protein MSS4, resulting in a reduced ability to inhibit protein synthesis [122] , and binds and stabilizes the MutS homolog hMSH4, a protein involved in doubl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25450521
sparser
"The interaction of MSH4 with eIF3f (a subunit of the eIF3 complex implicated in apoptosis regulation and tumor development), for example, occurs at the region comprising the first 150 amino acids of the N-terminal domain of MSH4 (where rs5745325 is located) and has been demonstrated to foster hMSH4 stabilization and to modulate sensitivity to IR-induced DNA damage [ xref ]."
32957448
biogrid
No evidence text available
23725059
biogrid
No evidence text available
23725059
biogrid
No evidence text available
23725059
reach
"Here, we demonstrate that hMSH4 interacts with eIF3f - a regulatory subunit of the eIF3 complex that has also been implicated in the regulation of apoptosis and tumorigenesis in humans [XREF_BIBR - XREF_BIBR]."
23725059
biogrid
No evidence text available
23725059
biogrid
No evidence text available
23725059
reach
"HMSH4 interacts with eIF3f."
23725059
MSH4 activates EIF3F.
| 2
MSH4 activates EIF3F. 2 / 5
| 2
reach
"Conversely, eIF3f significantly increased the sensitivity of cells treated with 2Gy IR and hMSH4 substantially promoted this effect."
23725059
reach
"Furthermore, the interplay between hMSH4 and eIF3f inhibits IR induced AKT activation, and hMSH4 promotes eIF3f mediated bypass of S phase arrest, and ultimately enhancing an early G2/M arrest in response to IR treatment."
23725059
EIF3F affects EIF3B
1 17 | 1 6
EIF3F binds EIF3B. 10 / 25
17 | 1 6
biogrid
No evidence text available
28514442
sparser
"The association of eIF3f with eIF3b diminished after 48 h."
19245811
biogrid
No evidence text available
18599441
biogrid
No evidence text available
24981860
sparser
"The ICP27 of HSV, a multiple function protein involved in regulating synthesis of viral proteins and host proteins during HSV infection, interacts with eIF3b and eIF3f [79] ."
16829125
biogrid
No evidence text available
35271311
biogrid
No evidence text available
31527668
biogrid
No evidence text available
26186194
biogrid
No evidence text available
18628297
biogrid
No evidence text available
30573685
EIF3B binds EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L. 1 / 1
1 |
signor
"Consistent with its diverse functions, eIF3 is the largest and most complex initiation factor: the mammalian version, for example, contains 13 nonidentical subunits that are designated eIF3a to eIF3m 8, 9, 10, 11, 12, 13 (Table 1)."
16920360
CDK11B affects EIF3F
1 9 2 1 | 13
CDK11B phosphorylates EIF3F.
1 5 1 | 6
CDK11B phosphorylates EIF3F on S46. 5 / 5
1 2 1 | 1
phosphoelm
No evidence text available
12446680
signor
"EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
biopax:phosphositeplus
No evidence text available
reach
"CDK11 and eIF3f co-localize within the nucleus, and in vitro, CDK11 specifically phosphorylates eIF3f Ser46, a residue that is included in N91-eIF3f."
19854136
signor
"The interaction between cdk11p46 and eif3 p47 occurs in vitro and in vivo. In addition, cdk11 protein kinase isolated from cells undergoing apoptosis can phosphorylate eif3 p47in vitro, and serine phosphorylation of eif3 p47 occurs in cells during apoptosis.Purified recombinant cdk11p46 inhibited translation of a reporter gene in vitro in a dose-dependent manner.These data suggest that the function of the caspase-processed cdk11p110 isoform may be to inhibit translation during apoptosis. However, whether or not this inhibition of protein translation occurs in an eif3 p47-dependent or -independent manner remains to be clarified."
12446680
CDK11B phosphorylates EIF3F. 4 / 4
| 4
reach
"Results from the present study suggest that phosphorylation of eIF3f by CDK11 may contribute to the regulation of protein synthesis and apoptosis."
19245811
reach
"However, recent studies also demonstrated that CDK11p46 phosphorylates eIF3f, leading to increased association of eIF3f with eIF3 core complex and inhibition of translation [13,15] ."
21371428
reach
"21 During apoptosis, endogenous eIF3f is phosphorylated by CDK11 which is mainly a nuclear protein XREF_BIBR, XREF_BIBR and can assembly with other eIF3 subunits to form nuclear complexes which are involved in functions other than translation initiation, such as ribosome biogenesis that takes place into nucleus."
26052528
reach
"They also demonstrated that endogenous CDK11 p46 immunoprecipitated from apoptotic cells can phosphorylate bacterial recombinant eIF3 p47 in vitro [200] ."
15935619
CDK11B phosphorylates EIF3F on T119. 2 / 2
2 |
signor
"Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
signor
"Here, we identified a second eif3f phosphorylation site (thr119) by cdk11p46 during apoptosis.Thr119 is located in the mov34 domain of eif3f which is important for both the translational inhibitory function of eif3ffurther studies of how eif3f phosphorylation regulates its function will refine insights into the mechanism and regulation of translation initiation, apoptotic signaling, and tumorigenesis."
19245811
CDK11B bound to CCND3 phosphorylates EIF3F on T119. 1 / 1
1 |
signor
"Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
CDK11B-P46M phosphorylates EIF3F. 1 / 1
| 1
reach
"We have shown that CDK11 p46M can not phosphorylate eIF3f [XREF_BIBR]."
19245811
CDK11B binds EIF3F.
2 | 7
CDK11B binds EIF3F. 9 / 9
2 | 7
reach
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
19854136
reach
"We demonstrate that the eIF3 p47 can interact with CDK11 in vitro and in vivo, and the interaction can be strengthened by stimulation of apoptosis."
12446680
reach
"We confirmed that eIF3f interacts with CDK11 and showed that there is a specific interaction between eIF3f and 9G8 in vivo."
19854136
reach
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3 ' end processing of the HIV-1 pre-mRNA in a sequence specific manner."
19854136
reach
"To test whether a previously undescribed interaction between eIF3f and 9G8 exists and to confirm the previously reported interaction between CDK11 and eIF3f in our cell line, TE671, we performed co-immunoprecipitation experiments."
19854136
biogrid
No evidence text available
36736316
reach
"Together these results show that CDK11 and 9G8 both interact with eIF3f."
19854136
reach
"A mechanism by which N91-eIF3f inhibits HIV mRNA 3 ' end processing was suggested by the observation that eIF3f interacts directly with CDK11, both in vitro and in vivo."
19854136
biogrid
No evidence text available
19245811
CDK11B activates EIF3F.
4 |
CDK11B bound to CCND3 activates EIF3F. 2 / 2
2 |
signor
"Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
signor
"EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
CDK11B activates EIF3F. 2 / 2
2 |
signor
"EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
signor
"Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
RABIF affects EIF3F
1 | 10 10
RABIF binds EIF3F.
1 | 9 10
EIF3F binds RABIF. 10 / 23
1 | 9 10
reach
"35 We showed here that the Mss4 protein amount not only increases during first stages of stress stimulation, but that Mss4 also efficiently binds the eIF3f protein."
22495352
reach
"On the basis of these results and the already published data, we hypothesize that Mss4 binds eIF3f avoiding its interaction with and phosphorylation by CDK11p46 (XREF_FIG)."
22495352
sparser
"Molecular analysis of the Mss4-mediated inhibition of apoptosis showed that interaction of Mss4 with eIF3f (eukaryotic translation initiation factor 3 subunit f), a member of the translation initiation complex and a protein with distinct pro-apoptotic properties, is the critical event in the anti-apoptotic action of Mss4."
22495352
reach
"Under normal conditions, Mss4 is tightly bound to eIF3f, inhibiting its phosphorylation and subsequent association with eIF3 complex."
23354061
reach
"Molecular analysis of the Mss4 mediated inhibition of apoptosis showed that interaction of Mss4 with eIF3f (eukaryotic translation initiation factor 3 subunit f), a member of the translation initiation complex and a protein with distinct pro apoptotic properties, is the critical event in the anti-apoptotic action of Mss4."
22495352
biogrid
No evidence text available
32296183
sparser
"Interaction of Mss4 with eIF3F prevents the eIF3F-mediated apoptosis."
22495352
sparser
"Under normal conditions, Mss4 is tightly bound to eIF3f, inhibiting its phosphorylation and subsequent association with eIF3 complex."
23354061
sparser
"To study whether stress application influences the binding of Mss4 to eIF3f, HEK293 cells were transfected with myc-tagged eIF3f along with GST-tagged Mss4 and stimulated for 8h with 5 mM H 2 O 2 or left untreated."
22495352
reach
"To study whether stress application influences the binding of Mss4 to eIF3f, HEK293 cells were transfected with myc tagged eIF3f along with GST tagged Mss4 and stimulated for 8h with 5 mM H 2 O 2 or left untreated."
22495352
RABIF inhibits EIF3F.
| 1
RABIF inhibits EIF3F. 1 / 2
| 1
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR To study whether Mss4 is capable to abolish this specific property of eIF3f protein, A7 melanoma cells were transfected with pCS2+ MT empty vector, pCS2+ MT-Mss4 and pCS2+ MT-eIF3f or both plasmids together in addition to pRL-CMV vector in which the luciferase reporter gene is controlled by the CMV promoter."
22495352
CLU affects EIF3F
4 | 7 10
CLU binds EIF3F. 10 / 25
4 | 7 10
sparser
"In addition, eIF3F can stabilize p53 and interact with CLU protein, a secretory heterodimeric glycoprotein thus leading to cancer cell proliferation in humans functioning as a CLU inhibitor xref ."
29167521
sparser
"EIF3f interacts with CLU in the cytoplasm."
26988917
sparser
"These results suggest that eIF3f might interact with CLU protein to reduce the expression of sCLU in both intracellular and extracellular compartments by preventing structural changes."
26988917
sparser
"As shown in Figure xref , the region between amino acids 1 and 227 of CLU interacts directly with eIF3f, whereas the region between amino acids 1 and 169 of eIF3f interacts directly with CLU and was phosphorylated by CDK11p46 during apoptosis [ xref , xref ] (Figure xref )."
26988917
sparser
"The interaction between CLU and eIF3f was confirmed by growth assays and Δ-galactosidase assays using a yeast two-hybrid system."
26988917
sparser
"These results suggest that CLU can bind directly to eIF3f."
26988917
sparser
"Therefore, these results suggest that eIF3f and CLU strongly interact with each other in the cytoplasm."
26988917
sparser
"To identify the specific region responsible for the interaction between CLU and eIF3f, we generated four deletion constructs for CLU and eIF3f each and performed yeast two-hybrid assays."
26988917
reach
"These results suggest that CLU can bind directly to eIF3f."
26988917
reach
"To identify the specific region responsible for the interaction between CLU and eIF3f, we generated four deletion constructs for CLU and eIF3f each and performed yeast two-hybrid assays."
26988917
EIF3F affects MSH4
5 | 11 1
EIF3F binds MSH4.
5 | 10 1
MSH4 binds EIF3F. 10 / 21
5 | 10 1
reach
"To further validate the existence of a direct physical interaction between hMSH4 and eIF3f, we next performed a GST pull-down analysis of recombinant His 6 -hMSH4 and GST-eIF3f proteins."
23725059
reach
"EIF3f also binds to the stress-stimulated protein MSS4, resulting in a reduced ability to inhibit protein synthesis [122] , and binds and stabilizes the MutS homolog hMSH4, a protein involved in doubl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25450521
sparser
"The interaction of MSH4 with eIF3f (a subunit of the eIF3 complex implicated in apoptosis regulation and tumor development), for example, occurs at the region comprising the first 150 amino acids of the N-terminal domain of MSH4 (where rs5745325 is located) and has been demonstrated to foster hMSH4 stabilization and to modulate sensitivity to IR-induced DNA damage [ xref ]."
32957448
biogrid
No evidence text available
23725059
biogrid
No evidence text available
23725059
biogrid
No evidence text available
23725059
reach
"Here, we demonstrate that hMSH4 interacts with eIF3f - a regulatory subunit of the eIF3 complex that has also been implicated in the regulation of apoptosis and tumorigenesis in humans [XREF_BIBR - XREF_BIBR]."
23725059
biogrid
No evidence text available
23725059
biogrid
No evidence text available
23725059
reach
"HMSH4 interacts with eIF3f."
23725059
EIF3F activates MSH4.
| 1
EIF3F activates MSH4. 1 / 3
| 1
reach
"To understand the function of the eIF3f-hMSH4 interaction, we examined whether eIF3f promoted the stabilization of hMSH4."
23725059
POLDIP3 affects EIF3F
| 1 22
POLDIP3 phosphorylates EIF3F.
| 1 20
POLDIP3 phosphorylates EIF3F. 10 / 17
| 17
sparser
"EIF3f can be phosphorylated by CDK11 p46 during apoptosis [ xref ]."
18381585
sparser
"We demonstrated that eIF3f is directly phosphorylated by CDK11 p46 in vivo ."
19245811
sparser
"CDK11 p46 phosphorylates eIF3f at more than one site during apoptosis."
19245811
sparser
"To analyze whether endogenous eIF3f is directly phosphorylated by CDK11 p46 , A375 cells were transfected with CDK11 p46 ."
19245811
sparser
"Endogenous phosphorylation of eIF3f by CDK11 p46 ."
19245811
sparser
"It was recently reported that CDK11 p58 repressed cap-dependent mRNA translation by phosphorylating subunit eIF3F of the translation factor eIF3 complex [ 81 ], confirming a previous study showing tha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32446654
sparser
"To further confirm the endogenous phosphorylation of eIF3f by CDK11 p46 during apoptosis, A375 cells were treated with anti-Fas and/or caspase 3 inhibitor (DEVD-FMK). [CDK11 p46 was produced in anti-Fas treated cells, whereas caspase 3 inhibitor blocked the production of CDK11 p46 ( xref )."
19245811
sparser
"To investigate if it is the only phosphorylation site in eIF3f that is phosphorylated by CDK11 p46 , Ser46 of eIF3f was mutated to alanine."
19245811
sparser
"We previously showed that eIF3f is phosphorylated by CDK11 p46 which is an important effector in apoptosis."
19245811
sparser
"This data is consistent with our previous in vitro kinase assay data and endogenous serine phosphorylation data that eIF3f is phosphorylated by CDK11 p46 after apoptotic stimulation, especially around 36 h [ xref ]."
19245811
POLDIP3 phosphorylates EIF3F on S46. 3 / 3
| 3
sparser
"The caspase-processed CDK11 p46 phosphorylated eIF3f at Ser 46 in vitro and eIF3f was also phosphorylated in vivo during apoptosis."
16829125
sparser
"EIF3f is phosphorylated by CDK11 p46 at Ser46 during apoptosis."
19245811
sparser
"We have shown that CDK11 p46 phosphorylates eIF3f at Ser46 [ xref ]."
19245811
POLDIP3 phosphorylates EIF3F on serine. 1 / 1
| 1
reach
"We show in vitro that the caspase processed CDK11 (p46) can phosphorylate eIF3 p47 at a specific serine residue (Ser (46)) and that eIF3 p47 is phosphorylated in vivo during apoptosis."
12446680
POLDIP3 binds EIF3F.
| 2
POLDIP3 binds EIF3F. 2 / 2
| 2
sparser
"The binding and phosphorylation of eIF3f by CDK11 p46 may be one of the factors responsible for inhibition of global translation during apoptosis."
16829125
sparser
"Thr119 is located in the Mov34 domain of eIF3f which is important for both the translational inhibitory function of eIF3f [ xref ] and the protein-protein interaction of eIF3f with CDK11 p46 [ xref ]."
19245811
EIF3F affects cell growth
| 17 2
EIF3F inhibits cell growth.
| 13 2
EIF3F inhibits cell growth. 10 / 19
| 13 2
reach
"The same group found that eIF3f overexpression in cancer cells negatively regulates cell growth by affecting the translation efficiency and the activation of apoptosis."
23769948
reach
"The data also suggest that eIF3f inhibits cancer cell growth and induces apoptosis by blocking the function of sCLU, thereby suppressing the inactivation of p53 and Bax as well as the Akt and ERK pathways."
26988917
sparser
"Endogenous eIF3f silencing by antisense RNA or siRNA inhibits cell growth and induces apoptosis in A549 cancer cells."
20462454
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR Advances in the understanding of the molecular mechanism behind cellular carcinogenesis have shown that ectopic expression of eIF3f by transient gene transfection inhibits translation, cellular growth and proliferation and induces apoptosis."
26052528
sparser
"We also previously showed that ectopic expression of eIF3f inhibited cell growth and induced apoptosis xref ."
22457825
reach
"Ectopic overexpression of each eIF3 subunit (with the exception of eIF3m) in NIH 3T3 cells revealed that subunits eIF3a, eIF3b, eIF3c, eIF3h, and eIF3i stimulated global protein synthesis, accelerated[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27426745
reach
"Ectopic expression of eIF3e and eIF3f subunits in stably transfected NIH3T3 fibroblasts also inhibits cell growth and proliferation [XREF_BIBR]."
23354061
reach
"We also previously showed that ectopic expression of eIF3f inhibited cell growth and induced apoptosis XREF_BIBR."
22457825
reach
"It is demonstrated that the enforced expression of eIF3f inhibits translation, cell growth, cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, while knockdown of eIF3f i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29908282
reach
"Increased expression of eIF3f reduces cellular growth by inducing apoptosis in melanoma and pancreatic cancer cells [XREF_BIBR - XREF_BIBR]."
26988917
EIF3F activates cell growth.
| 4
Modified EIF3F activates cell growth. 2 / 2
| 2
reach
"Exogenous expression of shRNA resistant eIF3f in eIF3f knockdown cells restored Akt phosphorylation levels and cell growth."
32440143
reach
"Furthermore, ectopic expression of shRNA resistant eIF3f in eIF3f knockdown cells restored Akt phosphorylation levels and cell growth."
32440143
EIF3F activates cell growth. 2 / 2
| 2
reach
"These results confirmed that the inhibition of eIF3f significantly blocked PCa cell growth in vivo."
32440143
reach
"Endogenous eIF3f silencing by antisense RNA or siRNA inhibits cell growth and induces apoptosis in A549 cancer cells."
20462454
EIF3F affects RABIF
1 | 9 10
EIF3F binds RABIF. 10 / 23
1 | 9 10
reach
"35 We showed here that the Mss4 protein amount not only increases during first stages of stress stimulation, but that Mss4 also efficiently binds the eIF3f protein."
22495352
reach
"On the basis of these results and the already published data, we hypothesize that Mss4 binds eIF3f avoiding its interaction with and phosphorylation by CDK11p46 (XREF_FIG)."
22495352
sparser
"Molecular analysis of the Mss4-mediated inhibition of apoptosis showed that interaction of Mss4 with eIF3f (eukaryotic translation initiation factor 3 subunit f), a member of the translation initiation complex and a protein with distinct pro-apoptotic properties, is the critical event in the anti-apoptotic action of Mss4."
22495352
reach
"Under normal conditions, Mss4 is tightly bound to eIF3f, inhibiting its phosphorylation and subsequent association with eIF3 complex."
23354061
reach
"Molecular analysis of the Mss4 mediated inhibition of apoptosis showed that interaction of Mss4 with eIF3f (eukaryotic translation initiation factor 3 subunit f), a member of the translation initiation complex and a protein with distinct pro apoptotic properties, is the critical event in the anti-apoptotic action of Mss4."
22495352
biogrid
No evidence text available
32296183
sparser
"Interaction of Mss4 with eIF3F prevents the eIF3F-mediated apoptosis."
22495352
sparser
"Under normal conditions, Mss4 is tightly bound to eIF3f, inhibiting its phosphorylation and subsequent association with eIF3 complex."
23354061
sparser
"To study whether stress application influences the binding of Mss4 to eIF3f, HEK293 cells were transfected with myc-tagged eIF3f along with GST-tagged Mss4 and stimulated for 8h with 5 mM H 2 O 2 or left untreated."
22495352
reach
"To study whether stress application influences the binding of Mss4 to eIF3f, HEK293 cells were transfected with myc tagged eIF3f along with GST tagged Mss4 and stimulated for 8h with 5 mM H 2 O 2 or left untreated."
22495352
EIF3F affects PHGDH
| 1 17 3
EIF3F increases the amount of PHGDH.
| 6
EIF3F increases the amount of PHGDH. 6 / 6
| 6
reach
"Collectively, these results validated the oncogenic role of eIF3f and that eIF3f promoted CRC progression via SGOC pathway reprogramming by regulating PHGDH expression.2.6 Wnt Signaling Transcriptionally Upregulates the Expression of eIF3f."
37544925
reach
"Additionally, Wnt signals transcriptionally activate the expression of eIF3f, which also exerts its deubiquitinating activity toward MYC, thereby increasing MYC-mediated PHGDH transcription."
37544925
reach
"21 We further checked the expression of PHGDH and CAD in eIF3f KD CRC cells and the immunoblotting results showed that knockdown of eIF3f significantly reduced the expression of PHGDH, while exerted little effect on CAD (Figure S2C, Supporting Information)."
37544925
reach
"Indeed, eIF3f KD leads to reduction of steady‐state expression of PHGDH (Figure 2D)."
37544925
reach
"In addition, eIF3f KD accelerates PHGDH protein turnover (Figure 2F), and leads to increased poly‐ubiquitination level of PHGDH (Figure 2G), while ectopic‐expression of eIF3f leads to increased steady‐state expression of PHGDH (Figure 2H) and reduced poly‐ubiquitination level of PHGDH in a dose‐dependent manner (Figure 2I)."
37544925
reach
"The data in this study suggest that eIF3f positively regulated PHGDH expression, thus influencing the SGOC pathway."
37544925
EIF3F deubiquitinates PHGDH.
| 5
EIF3F deubiquitinates PHGDH. 5 / 5
| 5
reach
"Furthermore, eIF3f exerts its oncogenic function by deubiquitinating PHGDH and MYC, which subsequently enhances SGOC pathway to promote CRC progression."
37544925
reach
"22 Based on the findings, it is possible that eIF3f may deubiquitinate PHGDH."
37544925
reach
"Taken together, eIF3f deubiquitinates PHGDH independent of translation regulation.2.3 FBXW7beta-Mediated PHGDH Ubiquitination through Binding the Phosphodegron of PHGDH in a GSK3beta-Dependent Manner."
37544925
reach
"To further understand the mechanism of eIF3f‐mediated PHGDH deubiquitylation, we investigate the ubiquitin E3 ligase for PHGDH in CRC."
37544925
reach
"Likewise, Pan et al[33] recently revealed that PHGDH can serve as a novel substrate for GSK3β/FBXW7β, and that eIF3f can enhance the serine one-carbon metabolic pathway to promote CRC progression by deubiquitinating PHGDH."
38425409
EIF3F binds PHGDH.
| 1 3
PHGDH binds EIF3F. 4 / 4
| 1 3
sparser
"Thus, therapeutic approaches targeting eIF3f‐PHGDH axis represent an attractive strategy for eIF3f‐overexpressing CRC patients and further developing compounds that suppress eIF3f‐mediated PHGDH stabilization and inhibit Wnt signals are worthy of more investigation."
37544925
reach
"Further, co‐IP result confirmed the interaction between eIF3f and FBXW7β suggesting that eIF3f, FBXW7 and PHGDH may form a complex (Figure S3H, Supporting Information)."
37544925
sparser
"Our data shed light on eIF3f upstream regulatory circuit and reveal how EGF/Wnt oncogenic signal in promoting eIF3f‐PHGDH axis to enhance the SGOC pathway, thereby affecting tumorigenesis ( Figure xref )."
37544925
sparser
"In summary, the present study demonstrates that eIF3f is a critical oncogenic factor and provides strong evidence for eIF3f‐PHGDH axis as a novel therapeutic target for CRC patients."
37544925
EIF3F ubiquitinates PHGDH.
| 2
EIF3F leads to the ubiquitination of PHGDH. 2 / 2
| 2
reach
"Moreover, we uncover that PHGDH is a novel substrate of GSK3β/FBXW7β and eIF3f could deubiquitinate FBXW7β‐mediated ubiquitination of PHGDH."
37544925
reach
"EIF3f with MPN domain deleted (ΔMPN) or N‐terminal deleted (aa 1–91 deleted, ΔN) has attenuated its ability in decreasing PHGDH ubiquitination, suggesting that these domains are involved in DUB activity (Figure 2K)."
37544925
EIF3F decreases the amount of PHGDH.
| 2
EIF3F decreases the amount of PHGDH. 2 / 2
| 2
reach
"In addition, eIF3f KD accelerates PHGDH protein turnover (Figure 2F), and leads to increased poly‐ubiquitination level of PHGDH (Figure 2G), while ectopic‐expression of eIF3f leads to increased steady‐state expression of PHGDH (Figure 2H) and reduced poly‐ubiquitination level of PHGDH in a dose‐dependent manner (Figure 2I)."
37544925
reach
"Immunohistochemistry and immunoblotting showed that tumors with eIF3f KD exhibited a marked reduction in proliferation marker Ki‐67 and reduced the PHGDH, PSPH, PSAT1, and MYC expression (Figure 5E)."
37544925
EIF3F inhibits PHGDH.
| 1
EIF3F inhibits PHGDH. 1 / 1
| 1
reach
"In addition, eIF3f KD accelerates PHGDH protein turnover (Figure 2F), and leads to increased poly‐ubiquitination level of PHGDH (Figure 2G), while ectopic‐expression of eIF3f leads to increased steady‐state expression of PHGDH (Figure 2H) and reduced poly‐ubiquitination level of PHGDH in a dose‐dependent manner (Figure 2I)."
37544925
EIF3F activates PHGDH.
| 1
EIF3F activates PHGDH. 1 / 1
| 1
eidos
"Thereby , both impacts allow eIF3f to elevate the expression of PHGDH , enhancing Serine-Glycine-One-Carbon ( SGOC ) signaling pathway to facilitate CRC development ."
37544925
CDK19 affects EIF3F
2 2 | 15 1
CDK19 phosphorylates EIF3F.
2 1 | 8 1
CDK19 phosphorylates EIF3F. 7 / 7
| 7
sparser
"Phosphorylation of eIF3f by CDK11 p46 regulates its function in translation and apoptosis."
19245811
sparser
"Results from the present study suggest that phosphorylation of eIF3f by CDK11 may contribute to the regulation of protein synthesis and apoptosis."
19245811
sparser
"Based on our observations, the model that we propose depicts that the phosphorylation of eIF3f by CDK11 p46 enhances its binding to different sub-fractions of the eIF3 complex during apoptosis."
19245811
sparser
"Our findings are in line with previous observations reporting that endogenous eIF3f can localize at both cytoplasm and nuclear levels. xref During apoptosis, endogenous eIF3f is phosphorylated by CDK11 which is mainly a nuclear protein xref , xref and can assembly with other eIF3 subunits to form nuclear complexes which are involved in functions other than translation initiation, such as ribosome biogenesis that takes place into nucleus. xref The observation of nuclear localization together with the apoptotic effect observed by Annexin V assay strongly suggests that the exogenous and endogenous eIF3f are subjected to similar intracellular processing."
26052528
sparser
"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
19245811
sparser
"To examine whether phosphorylation of eIF3f by CDK11 p46 regulates its function, we mutated the Ser46 and Thr119 to alanine (A)."
19245811
sparser
"These results further indicated that the phosphorylation of eIF3f by CDK11 p46 contributes to its increased association with eIF3 core complex and apoptosis."
19245811
CDK19 phosphorylates EIF3F on S46. 4 / 4
1 1 | 1 1
rlimsp
"We show in vitro that the caspase-processed CDK11(p46) can phosphorylate eIF3 p47 at a specific serine residue (Ser(46)) and that eIF3 p47 is phosphorylated in vivo during apoptosis."
12446680
hprd
No evidence text available
12446680
biopax:phosphositeplus
No evidence text available
sparser
"CDK11 and eIF3f co-localize within the nucleus, and in vitro, CDK11 specifically phosphorylates eIF3f Ser46 ( xref ; xref ), a residue that is included in N91-eIF3f."
19854136
CDK19 phosphorylates EIF3F on T119. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CDK19 binds EIF3F.
1 | 7
CDK19 binds EIF3F. 5 / 5
1 | 4
sparser
"To test whether a previously undescribed interaction between eIF3f and 9G8 exists and to confirm the previously reported interaction between CDK11 and eIF3f in our cell line, TE671, we performed co-immunoprecipitation experiments."
19854136
sparser
"The FLAG-tagged CDK11 protein specifically interacted with endogenous eIF3f as well as overexpressed eIF3f-myc tagged protein ( xref , lanes 1 and 4), confirming previous reports ( xref )."
19854136
sparser
"A mechanism by which N91-eIF3f inhibits HIV mRNA 3’ end processing was suggested by the observation that eIF3f interacts directly with CDK11, both in vitro and in vivo ( xref )."
19854136
sparser
"We confirmed that eIF3f interacts with CDK11 and showed that there is a specific interaction between eIF3f and 9G8 in vivo ."
19854136
hprd
No evidence text available
12446680
EIF3F binds SLU7 and CDK19. 3 / 3
| 3
sparser
"Together these results show that CDK11 and 9G8 both interact with eIF3f."
19854136
sparser
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3’ end processing of the HIV-1 pre-mRNA in a sequence-specific manner."
19854136
sparser
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
19854136
EIF3M affects EIF3F
15 1 | 1 1
EIF3M binds EIF3F.
15 1 | 1
EIF3F binds EIF3M. 10 / 17
15 1 | 1
biogrid
No evidence text available
24981860
biogrid
No evidence text available
28514442
biogrid
No evidence text available
17403899
sparser
"The MPN subunits (f and h) bind to each other and attach to the rest of the octamer mainly through the association of eIF3f with eIF3m."
26344199
biogrid
No evidence text available
22939629
hprd
No evidence text available
16169070
biogrid
No evidence text available
33961781
biogrid
No evidence text available
32296183
biogrid
No evidence text available
26344197
biogrid
No evidence text available
35831314
EIF3M activates EIF3F.
| 1
EIF3M activates EIF3F. 1 / 1
| 1
reach
"EIF3m deficiency significantly down-regulated the subunits eIF3f, h, and c, and impaired the integrity of eIF3 (Zeng et al. 2013)."
27932584
EIF3F affects HNRNPK
2 | 5 9
EIF3F binds HNRNPK.
2 | 3 9
EIF3F binds HNRNPK. 10 / 15
2 | 3 9
biogrid
No evidence text available
22457825
biogrid
No evidence text available
22457825
reach
"Considering that hnRNP K protects rRNA from degradation whereas eIF3f promotes this process, Wen et al. [XREF_BIBR] have proposed that eIF3f may interact with hnRNP K during apoptosis and promote rRNA degradation by interfering with its rRNA protective function."
23354061
sparser
"We demonstrated that eIF3f directly interacts with hnRNP K. Under stress conditions, eIF3f dissociates hnRNP K from rRNA, thereby preventing it from protecting rRNA from degradation."
22457825
sparser
"EIF3f directly interacts with hnRNP K."
22457825
sparser
"Furthermore, recombinant eIF3f directly interacted with in vitro transcribed and translated hnRNP K ( xref )."
22457825
sparser
"During apoptosis, eIF3f might interact with heterogeneous nuclear ribonucleoprotein K blocking its RNA protective function."
25542647
reach
"During the apoptotic pathway, eIF3f is activated by CDK11p46, interacts with hnRNP K for RNA degradation, and is neutralized by Mss4."
23354061
sparser
"Therefore, the interaction between eIF3f and hnRNP K may take place in stress granules or in other cytoplasmic foci, but not in P bodies."
22457825
sparser
"Considering that hnRNP K protects rRNA from degradation whereas eIF3f promotes this process, Wen et al. [ xref ] have proposed that eIF3f may interact with hnRNP K during apoptosis and promote rRNA degradation by interfering with its rRNA protective function (Fig.  xref )."
23354061
EIF3F inhibits HNRNPK.
| 2
EIF3F inhibits HNRNPK. 2 / 3
| 2
reach
"Our data support a model (XREF_FIG) in which eIF3f sequesters hnRNP K to inhibit it 's binding to rRNA, which leads to increased rRNA degradation and attenuated translation."
22457825
reach
"Indeed, silencing of eIF3f increased the binding of hnRNP K to 28S rRNA by more than 9-fold (XREF_FIG)."
22457825
EIF3F affects EIF3E
12 | 6
EIF3F binds EIF3E. 10 / 12
12 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
40437099
biogrid
No evidence text available
24981860
biogrid
No evidence text available
17403899
biogrid
No evidence text available
31527668
biogrid
No evidence text available
33961781
EIF3F binds EIF3E and EIF3H. 5 / 5
| 5
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
EIF3E binds EIF3F and EIF3K. 1 / 1
| 1
sparser
"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
26399914
CDK11 p46 affects EIF3F
| 18
CDK11 p46 phosphorylates EIF3F. 10 / 15
| 15
reach
"CDK11 p46 phosphorylates eIF3f at more than one site during apoptosis."
19245811
reach
"This data is consistent with our previous in vitro kinase assay data and endogenous serine phosphorylation data that eIF3f is phosphorylated by CDK11 p46 after apoptotic stimulation, especially around 36 h [XREF_BIBR]."
19245811
reach
"This result strongly suggests that eIF3f is directly phosphorylated by CDK11 p46 in living cells."
19245811
reach
"Based on our observations, the model that we propose depicts that the phosphorylation of eIF3f by CDK11 p46 enhances its binding to different sub-fractions of the eIF3 complex during apoptosis."
19245811
reach
"Endogenous phosphorylation of eIF3f by CDK11 p46."
19245811
reach
"EIF3f can be phosphorylated by CDK11 p46 during apoptosis [XREF_BIBR]."
18381585
reach
"We have also presented data to show the direct phosphorylation of eIF3f by CDK11 p46 endogenously which confirmed our previous observations."
19245811
reach
"Phosphorylation of eIF3f by CDK11 p46 regulates its function in translation and apoptosis."
19245811
reach
"To examine whether phosphorylation of eIF3f by CDK11 p46 regulates its function, we mutated the Ser46 and Thr119 to alanine (A)."
19245811
reach
"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
19245811
CDK11 p46 phosphorylates EIF3F on S46. 3 / 3
| 3
reach
"We have shown that CDK11 p46 phosphorylates eIF3f at Ser46 [XREF_BIBR]."
19245811
reach
"The caspase processed CDK11 p46 phosphorylated eIF3f at Ser 46 in vitro and eIF3f was also phosphorylated in vivo during apoptosis."
16829125
reach
"EIF3f is phosphorylated by CDK11 p46 at Ser46 during apoptosis."
19245811
EIF3F affects EIF3M
15 1 | 1
EIF3F binds EIF3M. 10 / 17
15 1 | 1
biogrid
No evidence text available
24981860
biogrid
No evidence text available
28514442
biogrid
No evidence text available
17403899
sparser
"The MPN subunits (f and h) bind to each other and attach to the rest of the octamer mainly through the association of eIF3f with eIF3m."
26344199
biogrid
No evidence text available
22939629
hprd
No evidence text available
16169070
biogrid
No evidence text available
33961781
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No evidence text available
32296183
biogrid
No evidence text available
26344197
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No evidence text available
35831314
HNRNPK affects EIF3F
2 | 3 9
EIF3F binds HNRNPK. 10 / 15
2 | 3 9
biogrid
No evidence text available
22457825
biogrid
No evidence text available
22457825
reach
"Considering that hnRNP K protects rRNA from degradation whereas eIF3f promotes this process, Wen et al. [XREF_BIBR] have proposed that eIF3f may interact with hnRNP K during apoptosis and promote rRNA degradation by interfering with its rRNA protective function."
23354061
sparser
"We demonstrated that eIF3f directly interacts with hnRNP K. Under stress conditions, eIF3f dissociates hnRNP K from rRNA, thereby preventing it from protecting rRNA from degradation."
22457825
sparser
"EIF3f directly interacts with hnRNP K."
22457825
sparser
"Furthermore, recombinant eIF3f directly interacted with in vitro transcribed and translated hnRNP K ( xref )."
22457825
sparser
"During apoptosis, eIF3f might interact with heterogeneous nuclear ribonucleoprotein K blocking its RNA protective function."
25542647
reach
"During the apoptotic pathway, eIF3f is activated by CDK11p46, interacts with hnRNP K for RNA degradation, and is neutralized by Mss4."
23354061
sparser
"Therefore, the interaction between eIF3f and hnRNP K may take place in stress granules or in other cytoplasmic foci, but not in P bodies."
22457825
sparser
"Considering that hnRNP K protects rRNA from degradation whereas eIF3f promotes this process, Wen et al. [ xref ] have proposed that eIF3f may interact with hnRNP K during apoptosis and promote rRNA degradation by interfering with its rRNA protective function (Fig.  xref )."
23354061
EIF3F affects TP53
2 | 8
EIF3F activates TP53.
| 4
EIF3F activates TP53. 4 / 8
| 4
reach
"EIF3f overexpression activates p53 and Bax and inhibits Akt and ERK signaling."
26988917
reach
"EIF3f increases the stability of p53."
26988917
reach
"qRT-PCR revealed that eIF3f did not stimulate the upregulation of p53 mRNA, suggesting that eIF3f does not inhibit p53 levels."
26988917
reach
"These results suggest that eIF3f promotes the tumor suppressor function of p53 by increasing the stability of p53 protein."
26988917
EIF3F increases the amount of TP53.
| 2
EIF3F increases the amount of TP53. 2 / 3
| 2
reach
"As shown in Figure XREF_FIG, eIF3f transfection in HeLa cells upregulated the expression of the apoptotic proteins p53, p21, and Bax."
26988917
reach
"A previous result revealed that eIF3f increases p53 protein levels."
26988917
EIF3F decreases the amount of TP53.
| 2
EIF3F decreases the amount of TP53. 2 / 2
| 2
reach
"qRT-PCR revealed that eIF3f did not stimulate the upregulation of p53 mRNA, suggesting that eIF3f does not inhibit p53 levels."
26988917
reach
"Therefore, we assessed how eIF3f inhibits p53 expression using qRT-PCR and cycloheximide (CHX) assays."
26988917
EIF3F binds TP53.
2 |
TP53 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
29653964
biogrid
No evidence text available
29653964
EIF3F affects EIF3A
1 14 |
EIF3A binds EIF3F. 10 / 14
14 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
9822659
biogrid
No evidence text available
19615732
biogrid
No evidence text available
31527668
biogrid
No evidence text available
26344197
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
14519125
biogrid
No evidence text available
24396066
biogrid
No evidence text available
17353931
EIF3A binds EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L. 1 / 1
1 |
signor
"Consistent with its diverse functions, eIF3 is the largest and most complex initiation factor: the mammalian version, for example, contains 13 nonidentical subunits that are designated eIF3a to eIF3m 8, 9, 10, 11, 12, 13 (Table 1)."
16920360
EIF3F affects AKT
| 12
EIF3F phosphorylates AKT.
| 5
Modified EIF3F leads to the phosphorylation of AKT. 3 / 3
| 3
reach
"Ectopic expression of sheIF3f # 1 resistant eIF3f restored Akt phosphorylation in cells expressing sheIF3f # 1 (XREF_FIG)."
32440143
reach
"Furthermore, ectopic expression of shRNA resistant eIF3f in eIF3f knockdown cells restored Akt phosphorylation levels and cell growth."
32440143
reach
"Exogenous expression of shRNA resistant eIF3f in eIF3f knockdown cells restored Akt phosphorylation levels and cell growth."
32440143
EIF3F leads to the phosphorylation of AKT. 2 / 2
| 2
reach
"Disruption of eIF3f in PCa cells markedly inhibited the phosphorylation of Akt, whereas overexpression of sheIF3f resistant wild-type eIF3f in eIF3f knockdown PCa cells restored both cell viability and Akt phosphorylation."
32440143
reach
"EIF3f transfection was observed to significantly decrease the psCLU and alpha/beta CLU expression and inhibit Akt and ERK phosphorylation."
26988917
EIF3F inhibits AKT.
| 3
EIF3F inhibits AKT. 3 / 5
| 3
reach
"EIF3f overexpression activates p53 and Bax and inhibits Akt and ERK signaling."
26988917
reach
"Furthermore, eIF3f can suppress Akt and ERK signaling, as well as stabilize p53 [60] In our data, eIF3f was also down-regulated, as is the case in melanoma and pancreatic cancer."
32498447
reach
"Targeting eIF3f Suppresses the Growth of Prostate Cancer Cells by Inhibiting Akt Signaling."
32440143
EIF3F increases the amount of AKT.
| 2
Modified EIF3F increases the amount of AKT. 2 / 2
| 2
reach
"Exogenous expression of shRNA resistant eIF3f in eIF3f knockdown cells restored Akt phosphorylation levels and cell growth."
32440143
reach
"Furthermore, ectopic expression of shRNA resistant eIF3f in eIF3f knockdown cells restored Akt phosphorylation levels and cell growth."
32440143
EIF3F dephosphorylates AKT.
| 2
EIF3F leads to the dephosphorylation of AKT. 2 / 2
| 2
reach
"EIF3f Downregulation Inhibited Phosphorylation of Akt in PCa Cells."
32440143
reach
"EIF3f transfection was observed to significantly decrease the psCLU and alpha/beta CLU expression and inhibit Akt and ERK phosphorylation."
26988917
EIF3G affects EIF3F
1 11 |
EIF3F binds EIF3G. 10 / 11
11 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28514442
biogrid
No evidence text available
35271311
biogrid
No evidence text available
26344197
biogrid
No evidence text available
35831314
biogrid
No evidence text available
33961781
biogrid
No evidence text available
33961781
biogrid
No evidence text available
31527668
biogrid
No evidence text available
24981860
biogrid
No evidence text available
19615732
EIF3G binds EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L. 1 / 1
1 |
signor
"Consistent with its diverse functions, eIF3 is the largest and most complex initiation factor: the mammalian version, for example, contains 13 nonidentical subunits that are designated eIF3a to eIF3m 8, 9, 10, 11, 12, 13 (Table 1)."
16920360
EIF3F affects EIF3D
1 11 |
EIF3F binds EIF3D. 10 / 11
11 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
24981860
biogrid
No evidence text available
28514442
biogrid
No evidence text available
35831314
biogrid
No evidence text available
33961781
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26344197
biogrid
No evidence text available
22939629
biogrid
No evidence text available
31527668
biogrid
No evidence text available
19615732
EIF3D binds EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L. 1 / 1
1 |
signor
"Consistent with its diverse functions, eIF3 is the largest and most complex initiation factor: the mammalian version, for example, contains 13 nonidentical subunits that are designated eIF3a to eIF3m 8, 9, 10, 11, 12, 13 (Table 1)."
16920360
EIF3K affects EIF3F
1 8 | 1
EIF3F binds EIF3K. 8 / 9
8 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
biogrid
No evidence text available
24981860
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
biogrid
No evidence text available
35831314
EIF3E binds EIF3F and EIF3K. 1 / 1
| 1
sparser
"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
26399914
EIF3K binds EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L. 1 / 1
1 |
signor
"Consistent with its diverse functions, eIF3 is the largest and most complex initiation factor: the mammalian version, for example, contains 13 nonidentical subunits that are designated eIF3a to eIF3m 8, 9, 10, 11, 12, 13 (Table 1)."
16920360
EIF3F
8 2 | 1
EIF3F is active.
4 |
EIF3F phosphorylated on S46 is active. 2 / 2
2 |
signor
"EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
signor
"EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
EIF3F phosphorylated on T119 is active. 2 / 2
2 |
signor
"Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
signor
"Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
EIF3F is inactive.
4 |
EIF3F bound to S is inactive. 1 / 1
1 |
signor
"Coronavirus spike protein inhibits host cell translation by interaction with eIF3f"
18231581
EIF3F phosphorylated on S46 is inactive. 1 / 1
1 |
signor
"The interaction between cdk11p46 and eif3 p47 occurs in vitro and in vivo. In addition, cdk11 protein kinase isolated from cells undergoing apoptosis can phosphorylate eif3 p47in vitro, and serine phosphorylation of eif3 p47 occurs in cells during apoptosis.Purified recombinant cdk11p46 inhibited translation of a reporter gene in vitro in a dose-dependent manner.These data suggest that the function of the caspase-processed cdk11p110 isoform may be to inhibit translation during apoptosis. However, whether or not this inhibition of protein translation occurs in an eif3 p47-dependent or -independent manner remains to be clarified."
12446680
Ubiquitinated EIF3F is inactive. 1 / 1
1 |
signor
"Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome."
18354498
EIF3F bound to RBX1 is inactive. 1 / 1
1 |
signor
"Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome."
18354498
EIF3F binds.
2 |
EIF3F binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
31527668
EIF3F translocates.
| 1
EIF3F translocates from the cytoplasm to the nucleus. 1 / 1
| 1
sparser
"In C2C12 myotubes that undergo atrophy, MAFbx accumulates in the nucleus and triggers the translocation of eIF3f from the cytoplasm to the nucleus."
23354061
EIF3F affects EIF3K
1 8 | 1
EIF3F binds EIF3K. 8 / 9
8 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
biogrid
No evidence text available
24981860
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
biogrid
No evidence text available
35831314
EIF3E binds EIF3F and EIF3K. 1 / 1
| 1
sparser
"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
26399914
EIF3K binds EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L. 1 / 1
1 |
signor
"Consistent with its diverse functions, eIF3 is the largest and most complex initiation factor: the mammalian version, for example, contains 13 nonidentical subunits that are designated eIF3a to eIF3m 8, 9, 10, 11, 12, 13 (Table 1)."
16920360
EIF3F affects EIF3C
1 10 |
EIF3F binds EIF3C. 10 / 10
10 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
24981860
biogrid
No evidence text available
22939629
biogrid
No evidence text available
24396066
biogrid
No evidence text available
35831314
biogrid
No evidence text available
19615732
biogrid
No evidence text available
33961781
biogrid
No evidence text available
31527668
biogrid
No evidence text available
26344197
EIF3C binds EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L. 1 / 1
1 |
signor
"Consistent with its diverse functions, eIF3 is the largest and most complex initiation factor: the mammalian version, for example, contains 13 nonidentical subunits that are designated eIF3a to eIF3m 8, 9, 10, 11, 12, 13 (Table 1)."
16920360
STAT3 affects EIF3F
3 | 1 6
EIF3F binds STAT3. 10 / 10
3 | 1 6
sparser
"EIF3f knockdown in A549 cells was shown to inhibit cell proliferation and induce apoptosis. xref Esteves et al xref reported that eIF3f interacted with STAT3 and increased snail2 expression, thereby promoting lung cancer metastasis."
32440143
sparser
"The discovery of a role for EIF3F–STAT3 interaction in the genetic control of cell migration and metastasis in human lung adenocarcinoma could lead to the development of diagnosis and therapeutic strategies."
31527668
sparser
"The interaction between EIF3F and signal transducer and activator of transcription 3 (STAT3) controlled the EIF3F-mediated increase in Snail2 expression and cellular invasion, which were specifically abrogated using the STAT3 inhibitor Nifuroxazide or knockdown approaches."
31527668
sparser
"Therefore, our findings identify a novel EIF3F–STAT3 axis involved in the promotion of metastasis."
31527668
sparser
"Accordingly, immunoprecipitation (pull-down) analyses revealed the protein–protein molecular interaction between EIF3F and STAT3 (Supplementary information Fig. xref )."
31527668
biogrid
No evidence text available
31527668
biogrid
No evidence text available
31527668
sparser
"Therefore, our findings suggest that EIF3F could be considered as a novel effector of cell migration and metastasis, and its molecular link with STAT3 fosters the need to pursue investigations on the role of the EIF3F–STAT3 signaling in cancer."
31527668
reach
"XREF_BIBR Esteves et al XREF_BIBR reported that eIF3f interacted with STAT3 and increased snail2 expression, thereby promoting lung cancer metastasis."
32440143
biogrid
No evidence text available
31527668
EIF3L affects EIF3F
9 |
EIF3F binds EIF3L. 9 / 9
9 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
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No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
31527668
biogrid
No evidence text available
22939629
biogrid
No evidence text available
33961781
biogrid
No evidence text available
35831314
EIF3F affects Notch
2 | 3 4
EIF3F binds Notch.
| 1 4
EIF3F binds Notch. 5 / 5
| 1 4
sparser
"We show that Notch is only able to interact with eIF3f in the presence of the E3 ubiquitin ligase DTX and that a monoubiquitinated form of Notch is probably the substrate targeted by the DUB."
21124883
sparser
"With the help of another protein called Deltex1, which acts as a matchmaker, eIF3f associates with Notch when it is in the cell membrane, carrying a single ubiquitin protein."
21124857
sparser
"The activated form of Notch is able to interact with eIF3f only in the presence of the E3 ubiquitin ligase Deltex [ xref ]."
23354061
reach
"These results show that the tripartite interaction between Notch, DTX, and eIF3f occurs preferentially with activated, membrane associated, but gamma-secretase unprocessed, forms of Notch."
21124883
sparser
"These results show that the tripartite interaction between Notch, DTX, and eIF3f occurs preferentially with activated, membrane-associated, but γ-secretase unprocessed, forms of Notch."
21124883
EIF3F activates Notch.
1 | 2
EIF3F activates Notch. 3 / 3
1 | 2
reach
"The translation initiation factor 3f (EIF3F) is recruited to activate Notch on endocytic vesicles by the Deltex1 serving as a bridging factor."
28031783
reach
"These results suggest that eIF3f is specifically involved in an ubiquitination and deubiquitination process targeting activated Notch."
21124883
signor
"The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor."
21124883
EIF3F deubiquitinates Notch.
1 |
EIF3F deubiquitinates Notch. 1 / 1
1 |
signor
"The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor."
21124883
EIF3F affects MYC
2 | 7
EIF3F decreases the amount of MYC.
| 4
EIF3F decreases the amount of MYC. 4 / 4
| 4
reach
"Immunohistochemistry and immunoblotting showed that tumors with eIF3f KD exhibited a marked reduction in proliferation marker Ki‐67 and reduced the PHGDH, PSPH, PSAT1, and MYC expression (Figure 5E)."
37544925
reach
"Furthermore, eIF3f KD accelerated the turnover rate of MYC and increased the ubiquitination level of MYC (Figure 4I,J), while overexpression of eIF3f reduced the ubiquitination level of MYC in a dose‐dependent manner (Figure 4K)."
37544925
reach
"Interestingly, immunoblotting showed that KD of eIF3f could reduce protein level of MYC but has no impact on MYC mRNA expression level (Figure 4G–H and Figure S4B, Supporting Information)."
37544925
reach
"Taken together, these results indicated that GSK3β mediates PHGDH phosphorylation, which enhances the FBXW7β regulation on PHGDH ubiquitination.2.4 eIF3f Antagonizes the Ubiquitination Level of MYC, a Transcriptional Activator of PHGDH, Thereby Promoting MYC-Mediated Elevation of PHGDH."
37544925
EIF3F deubiquitinates MYC.
| 2
EIF3F deubiquitinates MYC. 2 / 2
| 2
reach
"Moreover, eIF3f can deubiquitinate and stabilize MYC, a Wnt target and a transcription activator of PHGDH, to regulate PHGDH transcriptionally."
37544925
reach
"Furthermore, eIF3f exerts its oncogenic function by deubiquitinating PHGDH and MYC, which subsequently enhances SGOC pathway to promote CRC progression."
37544925
EIF3F binds MYC.
2 |
MYC binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
36424410
biogrid
No evidence text available
29467282
EIF3F increases the amount of MYC.
| 1
EIF3F increases the amount of MYC. 1 / 1
| 1
reach
"Furthermore, eIF3f KD accelerated the turnover rate of MYC and increased the ubiquitination level of MYC (Figure 4I,J), while overexpression of eIF3f reduced the ubiquitination level of MYC in a dose‐dependent manner (Figure 4K)."
37544925
EIF3F affects EIF3L
9 |
EIF3F binds EIF3L. 9 / 9
9 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
31527668
biogrid
No evidence text available
22939629
biogrid
No evidence text available
33961781
biogrid
No evidence text available
35831314
EIF3F affects EIF3F
| 7
EIF3F decreases the amount of EIF3F.
| 2
EIF3F decreases the amount of EIF3F. 2 / 3
| 2
reach
"These findings suggest that eIF3f functions as a negative regulator of cell growth due to the naturally reduced levels of eIF3f contributing to cancer development and overexpression resulting in apoptosis [XREF_BIBR]."
28083147
reach
"To further confirm that eIF3f could affect hMSH4 stability, the levels of eIF3f in 293T/eIF3f-hMSH 4 cells were reduced by eIF3f RNAi, and the levels of hMSH4 were examined by immunoblotting."
23725059
EIF3F activates EIF3F.
| 3
EIF3F activates EIF3F. 3 / 3
| 3
reach
"Decreased expression of eIF3f inhibited CRC cell proliferation, colony formation (Figure S1D,E, Supporting Information) while overexpression of eIF3f promoted CRC cell colony formation (Figure S1F, Supporting Information), and eIF3f KD induced more apoptotic cells (Figure S1G, Supporting Information)."
37544925
reach
"Furthermore, we found that ectopic expression of sheIF3f # 1 resistant wild-type eIF3f rescued the proliferation rate of eIF3f knockdown cells (XREF_FIG)."
32440143
reach
"Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis."
19245811
EIF3F phosphorylates EIF3F.
| 1
EIF3F phosphorylates EIF3F on S46. 1 / 2
| 1
reach
"CDK11 and eIF3f co-localize within the nucleus, and in vitro, CDK11 specifically phosphorylates eIF3f Ser46, a residue that is included in N91-eIF3f."
19854136
EIF3F increases the amount of EIF3F.
| 1
EIF3F increases the amount of EIF3F. 1 / 1
| 1
reach
"The function of eIF3f in inhibition of translation was also supported by our observation that starvation caused an increase in the eIF3f level, in both primary fibroblast cells and pancreatic epithelial cells (XREF_FIG)."
22457825
EIF3F affects CDK11B
2 | 7
CDK11B binds EIF3F. 9 / 9
2 | 7
reach
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
19854136
reach
"We demonstrate that the eIF3 p47 can interact with CDK11 in vitro and in vivo, and the interaction can be strengthened by stimulation of apoptosis."
12446680
reach
"We confirmed that eIF3f interacts with CDK11 and showed that there is a specific interaction between eIF3f and 9G8 in vivo."
19854136
reach
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3 ' end processing of the HIV-1 pre-mRNA in a sequence specific manner."
19854136
reach
"To test whether a previously undescribed interaction between eIF3f and 9G8 exists and to confirm the previously reported interaction between CDK11 and eIF3f in our cell line, TE671, we performed co-immunoprecipitation experiments."
19854136
biogrid
No evidence text available
36736316
reach
"Together these results show that CDK11 and 9G8 both interact with eIF3f."
19854136
reach
"A mechanism by which N91-eIF3f inhibits HIV mRNA 3 ' end processing was suggested by the observation that eIF3f interacts directly with CDK11, both in vitro and in vivo."
19854136
biogrid
No evidence text available
19245811
Piwil1 affects EIF3F
| 8
Piwil1 binds EIF3F. 6 / 6
| 6
sparser
"We confirmed the interaction between MIWI and eIF3f by co-immunoprecipitation (coIP) in both co-transfected 293T cells ( xref ) and mouse testes ( xref )."
31835033
sparser
"To begin to determine whether MIWI-binding to eIF3f is required for translation activation of piRNA targets in mouse spermatids, we mapped the domain(s) in MIWI responsible for eIF3f-binding by testing a series of MIWI truncation mutants ( xref ) for coIP with full-length eIF3f."
31835033
sparser
"We found that a 150-aa (amino acid) MIWI N-terminal peptide (MIWI-N2) efficiently interacted with eIF3f and deletion of 10 aa at position 111–120 (MIWI-N2 Δ111–120 ) abolished its binding with eIF3f ( xref )."
31835033
sparser
"Importantly, MIWI-N2, but not MIWI-N2 Δ111–120 , effectively impaired the binding of full-length MIWI to eIF3f ( xref )."
31835033
sparser
"This indicates that the association of MIWI with eIF3f is temporally regulated during spermatogenesis."
31835033
sparser
"Interestingly, while the interaction between MIWI and eIF3f and the interaction between HuR and eIF4G3 are both independent of RNA, the formation of the MIWI/eIF3/HuR/eIF4G3 super-complex is RNA mediated."
31835033
Piwil1 binds EIF3F and ELAVL1. 2 / 2
| 2
sparser
"We next examined whether HuR associates with MIWI and eIF3f."
31835033
sparser
"Unlike 293T cells, mouse testes contain active piRNAs, and indeed, we detected significant association of endogenous HuR with both MIWI and eIF3f in mouse testes ( xref )."
31835033
reach
"These results suggested that eIF3f has an oncogenic role in PCa, mediated at least partially through the regulation of Akt signaling, and that eIF3f represents a potential target for the inhibition of PCa growth and progression."
32440143
reach
"The results indicated that silencing of eIF3f expression by lentiviral transfection significantly repressed tumor growth of PCa cells, both in vitro and in vivo."
32440143
reach
"The proliferation rates of shRNA lentivirus infected PCa cells indicated that eIF3f knockdown markedly decreased the proliferation of PCa cells (XREF_FIG)."
32440143
reach
"These results confirmed that the inhibition of eIF3f significantly blocked PCa cell growth in vivo."
32440143
reach
"These results indicated that eIF3f knockdown caused inhibition of PCa cell proliferation at least partially through the suppression of Akt phosphorylation."
32440143
reach
"In silico analyses suggested that eIF3f may promote the progression of PCa."
32440143
reach
"We confirmed that the loss of eIF3f reduced the proliferation of PCa cells, both in vitro and in vivo."
32440143
reach
"EIF3f silencing significantly suppressed the growth of PCa cells, both in vitro and in vivo."
32440143
EIF3F affects adrenoceptor
| 8
EIF3F activates adrenoceptor. 8 / 8
| 8
reach
"Figure XREF_FIG shows that the presence of eIF3f promotes adrenoceptor activation."
26497985
reach
"In the presence of catecholamine, eIF3f stimulates adrenoceptor activity."
26497985
reach
"In the present work, we report that eIF3f physically and stably interacts with the alpha 1B-ADR, and that eIF3f stimulates adrenoceptor activity."
26497985
reach
"The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity."
31026345
reach
"The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity."
26497985
reach
"Upon catecholamine stimulation, eIF3f promotes adrenoceptor activity in vitro, independently of the eIF3f proline- and alanine rich N-terminal region."
26497985
reach
"In this study, we found a novel physical interaction between human eIF3f and the alpha 1B-adrenergic receptor (alpha 1B-ADR) and that eIF3f stimulates adrenoceptor activity."
26497985
reach
"EIF3f promotes adrenoceptor activity upon catecholamine stimulation."
26497985
EIF3F affects Piwil1
| 8
Piwil1 binds EIF3F. 6 / 6
| 6
sparser
"We confirmed the interaction between MIWI and eIF3f by co-immunoprecipitation (coIP) in both co-transfected 293T cells ( xref ) and mouse testes ( xref )."
31835033
sparser
"To begin to determine whether MIWI-binding to eIF3f is required for translation activation of piRNA targets in mouse spermatids, we mapped the domain(s) in MIWI responsible for eIF3f-binding by testing a series of MIWI truncation mutants ( xref ) for coIP with full-length eIF3f."
31835033
sparser
"We found that a 150-aa (amino acid) MIWI N-terminal peptide (MIWI-N2) efficiently interacted with eIF3f and deletion of 10 aa at position 111–120 (MIWI-N2 Δ111–120 ) abolished its binding with eIF3f ( xref )."
31835033
sparser
"Importantly, MIWI-N2, but not MIWI-N2 Δ111–120 , effectively impaired the binding of full-length MIWI to eIF3f ( xref )."
31835033
sparser
"This indicates that the association of MIWI with eIF3f is temporally regulated during spermatogenesis."
31835033
sparser
"Interestingly, while the interaction between MIWI and eIF3f and the interaction between HuR and eIF4G3 are both independent of RNA, the formation of the MIWI/eIF3/HuR/eIF4G3 super-complex is RNA mediated."
31835033
Piwil1 binds EIF3F and ELAVL1. 2 / 2
| 2
sparser
"We next examined whether HuR associates with MIWI and eIF3f."
31835033
sparser
"Unlike 293T cells, mouse testes contain active piRNAs, and indeed, we detected significant association of endogenous HuR with both MIWI and eIF3f in mouse testes ( xref )."
31835033
EIF3F affects CDK19
1 | 7
CDK19 binds EIF3F. 5 / 5
1 | 4
sparser
"To test whether a previously undescribed interaction between eIF3f and 9G8 exists and to confirm the previously reported interaction between CDK11 and eIF3f in our cell line, TE671, we performed co-immunoprecipitation experiments."
19854136
sparser
"The FLAG-tagged CDK11 protein specifically interacted with endogenous eIF3f as well as overexpressed eIF3f-myc tagged protein ( xref , lanes 1 and 4), confirming previous reports ( xref )."
19854136
sparser
"A mechanism by which N91-eIF3f inhibits HIV mRNA 3’ end processing was suggested by the observation that eIF3f interacts directly with CDK11, both in vitro and in vivo ( xref )."
19854136
sparser
"We confirmed that eIF3f interacts with CDK11 and showed that there is a specific interaction between eIF3f and 9G8 in vivo ."
19854136
hprd
No evidence text available
12446680
EIF3F binds SLU7 and CDK19. 3 / 3
| 3
sparser
"Together these results show that CDK11 and 9G8 both interact with eIF3f."
19854136
sparser
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3’ end processing of the HIV-1 pre-mRNA in a sequence-specific manner."
19854136
sparser
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
19854136
CDK11p46 affects EIF3F
| 3 4
CDK11p46 phosphorylates EIF3F.
| 2 4
CDK11p46 phosphorylates EIF3F. 6 / 6
| 2 4
rlimsp
"When the number of Mss4 molecules in cells dropped down owing to ongoing stress, the CDK11p46 binds now and phosphorylates the released eIF3f resulting in inhibition of translation and initiation of apoptosis."
22495352
reach
"When the number of Mss4 molecules in cells dropped down owing to ongoing stress, the CDK11p46 binds now and phosphorylates the released eIF3f resulting in inhibition of translation and initiation of apoptosis."
22495352
rlimsp
"As shown in Figure 4, the region between amino acids 1 and 227 of CLU interacts directly with eIF3f, whereas the region between amino acids 1 and 169 of eIF3f interacts directly with CLU and was phosphorylated by CDK11p46 during apoptosis [29, 30] (Figure 4A, 4B)."
26988917
rlimsp
"When Mss4 proteins in cells drop-down owing to ongoing stress, the CDK11p46 can phosphorylate the released eIF3f."
23354061
rlimsp
"Two different phosphorylation sites have been identified in eIF3f during apoptosis: Ser46 [39] and Thr119 [60]. CDK11p46 phosphorylates both sites."
23354061
reach
"When Mss4 proteins in cells drop-down owing to ongoing stress, the CDK11p46 can phosphorylate the released eIF3f."
23354061
CDK11p46 binds EIF3F.
| 1
CDK11p46 binds EIF3F. 1 / 2
| 1
reach
"When the number of Mss4 molecules in cells dropped down owing to ongoing stress, the CDK11p46 binds now and phosphorylates the released eIF3f resulting in inhibition of translation and initiation of apoptosis."
22495352
EIF3I affects EIF3F
7 |
EIF3F binds EIF3I. 7 / 7
7 |
biogrid
No evidence text available
31527668
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28514442
EIF3F affects FBXO32
3 | 2 2
FBXO32 binds EIF3F. 7 / 7
3 | 2 2
biogrid
No evidence text available
19073596
biogrid
No evidence text available
18354498
biogrid
No evidence text available
18354498
reach
"Whether MAFbx interacts with free eIF3f or with eIF3f molecules bound to S6K1 still remains unclear."
23354061
sparser
"Whether MAFbx interacts with free eIF3f or with eIF3f molecules bound to S6K1 still remains unclear."
23354061
reach
"Interestingly, eIF3-f binds MAFbx in skeletal muscle, which explains, probably, protein synthesis decrease during muscle atrophy of different nature [XREF_BIBR]."
22496611
sparser
"Muscles undergoing atrophy accumulates the inactive form of S6K1 suggesting that degradation of eIF3f mediated by MAFbx participates to S6K1 inactivation during atrophy and raises the question whether MAFbx interacts with free eIF3f molecules or bound to hypophosphorylated S6K1."
20126553
EIF3F affects EIF3I
7 |
EIF3F binds EIF3I. 7 / 7
7 |
biogrid
No evidence text available
31527668
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28514442
Berberine affects EIF3F
| 6
Berberine inhibits EIF3F.
| 2
Berberine inhibits EIF3F. 2 / 2
| 2
reach
"Western blot assay also showed that berberine inhibited these protein (EIF3F and MALT1) expression ( Fig. 5 E and F)."
33539814
reach
"Berberine decreases eIF3-f and protein synthesis by an atrogin-1-dependent mechanism."
20522589
Berberine decreases the amount of EIF3F.
| 2
Berberine decreases the amount of EIF3F. 2 / 2
| 2
reach
"In this study, berberine inhibited the expression of MALT1 and EIF3F and subsequently suppressed the production of MIF and IL-4, suggesting that the regulation of MALT1 and EIF3F is involved in the at[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33539814
reach
"We proposed that this response could be linked to changes in the protein synthesis mediator, eIF3-f, because berberine also decreased the level of eIF3-f in muscles of wild-type and db/db mice (XREF_FIG A and B and XREF_FIG A)."
20522589
Berberine increases the amount of EIF3F.
| 1
Berberine increases the amount of EIF3F. 1 / 1
| 1
reach
"Therefore, we should dissolve this issue in a future study.We conclude that the regulation of the EIF3F and MALT1 expression by berberine is involved in the inhibitory effects on eotaxin, IL-4 and MIF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33539814
Berberine activates EIF3F.
| 1
Berberine activates EIF3F. 1 / 1
| 1
reach
"In addition, berberine induced anti-AD effects by downregulating cutaneous eukaryotic translation initiation factor 3 subunit F and mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mice with AD [106]."
38203638
SLU7 affects EIF3F
| 6
EIF3F binds SLU7 and CDK19. 3 / 3
| 3
sparser
"Together these results show that CDK11 and 9G8 both interact with eIF3f."
19854136
sparser
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3’ end processing of the HIV-1 pre-mRNA in a sequence-specific manner."
19854136
sparser
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
19854136
EIF3F binds SLU7. 3 / 3
| 3
sparser
"We confirmed that eIF3f interacts with CDK11 and showed that there is a specific interaction between eIF3f and 9G8 in vivo ."
19854136
sparser
"Furthermore, we observed that FLAG-tagged 9G8 specifically interacts with endogenous eIF3f and myc-tagged eIF3f ( xref , lanes 2 and 5)."
19854136
sparser
"To test whether a previously undescribed interaction between eIF3f and 9G8 exists and to confirm the previously reported interaction between CDK11 and eIF3f in our cell line, TE671, we performed co-immunoprecipitation experiments."
19854136
EIF3F affects 9G8
| 6
EIF3F binds 9G8. 6 / 6
| 6
reach
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3 ' end processing of the HIV-1 pre-mRNA in a sequence specific manner."
19854136
reach
"To test whether a previously undescribed interaction between eIF3f and 9G8 exists and to confirm the previously reported interaction between CDK11 and eIF3f in our cell line, TE671, we performed co-immunoprecipitation experiments."
19854136
reach
"Furthermore, we observed that FLAG tagged 9G8 specifically interacts with endogenous eIF3f and myc tagged eIF3f (XREF_FIG, lanes 2 and 5)."
19854136
reach
"Together these results show that CDK11 and 9G8 both interact with eIF3f."
19854136
reach
"We confirmed that eIF3f interacts with CDK11 and showed that there is a specific interaction between eIF3f and 9G8 in vivo."
19854136
reach
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
19854136
Notch affects EIF3F
| 1 4
EIF3F binds Notch. 5 / 5
| 1 4
sparser
"We show that Notch is only able to interact with eIF3f in the presence of the E3 ubiquitin ligase DTX and that a monoubiquitinated form of Notch is probably the substrate targeted by the DUB."
21124883
sparser
"With the help of another protein called Deltex1, which acts as a matchmaker, eIF3f associates with Notch when it is in the cell membrane, carrying a single ubiquitin protein."
21124857
sparser
"The activated form of Notch is able to interact with eIF3f only in the presence of the E3 ubiquitin ligase Deltex [ xref ]."
23354061
reach
"These results show that the tripartite interaction between Notch, DTX, and eIF3f occurs preferentially with activated, membrane associated, but gamma-secretase unprocessed, forms of Notch."
21124883
sparser
"These results show that the tripartite interaction between Notch, DTX, and eIF3f occurs preferentially with activated, membrane-associated, but γ-secretase unprocessed, forms of Notch."
21124883
EIF3H affects EIF3E
| 5
EIF3F binds EIF3E and EIF3H. 5 / 5
| 5
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
EIF3F affects STING1
| 1 1 2
EIF3F binds STING1.
| 1 2
STING1 binds EIF3F. 3 / 3
| 1 2
reach
"In uninfected cells or the early phase of infection, iRhom2 acts as an adaptor protein, promoting the interaction of STING and EIF3S5, a deubiquitinating enzyme, thereby inhibiting the degradation of STING (figure 2) [18]."
30890028
sparser
"In uninfected cells or the early phase of infection, iRhom2 acts as an adaptor protein, promoting the interaction of STING and EIF3S5, a deubiquitinating enzyme, thereby inhibiting the degradation of STING ( xref ) [ xref ]."
30890028
sparser
"EIF3S5 is recruited by inactive rhomboid protein 2 (iRhom2) and interacts with STING ( xref )."
36579404
EIF3F activates STING1.
| 1
EIF3F activates STING1. 1 / 2
| 1
eidos
"Additionally , iRhom2 protein assembles the deubiquitinase eukaryotic translation initiation factor 3S5 ( EIF3S5 ) , which acts to promote STING during this process.117 STING relocation from the ER and interaction with TBK1 in the perinuclear area , prompts the activation of IRF3 through phosphorylation.120 TBK1 phosphorylates the tail domain of the carboxy-terminal from STING , resulting in the assembly of IRF3 and its subsequent phosphorylation ."
32195086
EIF3F affects EIF4G1
1 3 |
EIF3F binds EIF4G1.
3 |
EIF3F binds EIF4G1. 3 / 4
3 |
biogrid
No evidence text available
24248602
biogrid
No evidence text available
19615732
biogrid
No evidence text available
17322308
EIF3F activates EIF4G1.
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L activates EIF4G1. 1 / 1
1 |
signor
"EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit"
17581632
EIF3F affects EIF3CL
5 |
EIF3F binds EIF3CL. 5 / 5
5 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
31527668
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EIF3E affects EIF3H
| 5
EIF3F binds EIF3E and EIF3H. 5 / 5
| 5
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
EIF3CL affects EIF3F
5 |
EIF3F binds EIF3CL. 5 / 5
5 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
31527668
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
Caspase affects EIF3F
| 4 1
Caspase binds EIF3F.
| 2 1
Caspase binds EIF3F. 2 / 2
| 1 1
reach
"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [XREF_BIBR] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation."
23354061
sparser
"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase-processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [ xref ] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation (Fig.  xref )."
23354061
Caspase binds EIF3F and Thr-119. 1 / 1
| 1
reach
"Moreover, caspase processed isoform of the cell division kinase 11 (Cdk11 p46) binds and phosphorylates eIF3f at Ser 46 and Thr 119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation."
23769948
Caspase phosphorylates EIF3F.
| 2
Caspase phosphorylates EIF3F. 2 / 2
| 2
reach
"The phosphorylation of the eIF3f subunit by the caspase activated form of CDK11 (cyclin dependent kinase 11) is also noteworthy [XREF_BIBR]."
23344027
reach
"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [XREF_BIBR] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation."
23354061
CDK11A affects EIF3F
3 | 2
CDK11A binds EIF3F.
3 |
EIF3F binds CDK11A. 3 / 3
3 |
biogrid
No evidence text available
36736316
biogrid
No evidence text available
12446680
biogrid
No evidence text available
12446680
CDK11A phosphorylates EIF3F.
| 2
CDK11A phosphorylates EIF3F. 2 / 2
| 2
rlimsp
"We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo."
19245811
rlimsp
"We previously showed that eIF3f is phosphorylated by cyclin dependent kinase 11 (CDK11(p46)) which is an important effector in apoptosis."
19245811
Bisphenol A affects EIF3F
3 | 1
Bisphenol A increases the amount of EIF3F.
3 |
Bisphenol A increases the amount of EIF3F. 3 / 3
3 |
ctd
No evidence text available
33243503
ctd
No evidence text available
33221593
ctd
No evidence text available
32156529
Bisphenol A activates EIF3F.
| 1
Bisphenol A activates EIF3F. 1 / 1
| 1
reach
"Eif3f was upregulated by both long- and short-term BPA exposures."
33243503
PRRC2B affects EIF3F
4 |
EIF3F binds PRRC2B. 4 / 4
4 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
PHGDH affects EIF3F
| 1 3
PHGDH binds EIF3F. 4 / 4
| 1 3
sparser
"Thus, therapeutic approaches targeting eIF3f‐PHGDH axis represent an attractive strategy for eIF3f‐overexpressing CRC patients and further developing compounds that suppress eIF3f‐mediated PHGDH stabilization and inhibit Wnt signals are worthy of more investigation."
37544925
reach
"Further, co‐IP result confirmed the interaction between eIF3f and FBXW7β suggesting that eIF3f, FBXW7 and PHGDH may form a complex (Figure S3H, Supporting Information)."
37544925
sparser
"Our data shed light on eIF3f upstream regulatory circuit and reveal how EGF/Wnt oncogenic signal in promoting eIF3f‐PHGDH axis to enhance the SGOC pathway, thereby affecting tumorigenesis ( Figure xref )."
37544925
sparser
"In summary, the present study demonstrates that eIF3f is a critical oncogenic factor and provides strong evidence for eIF3f‐PHGDH axis as a novel therapeutic target for CRC patients."
37544925
GLE1 affects EIF3F
1 | 2
GLE1 binds EIF3F. 3 / 4
1 | 2
biogrid
No evidence text available
18724935
reach
"Our previous studies found that hGle1 localization at the NPC is dependent on interactions with both hNup155 and hCG1, and that hGle1 interacts with the translation initiation factor eIF3f."
24243016
reach
"While a direct role for hGle1 in translation initiation or translation termination has not been documented to date, it has been shown that hGle1 directly interacts with eIF3f, a subunit of the translation initiation machinery."
24275432
EIF4G1 affects EIF3F
3 |
EIF3F binds EIF4G1. 3 / 4
3 |
biogrid
No evidence text available
24248602
biogrid
No evidence text available
19615732
biogrid
No evidence text available
17322308
EIF4E affects EIF3F
3 | 1
EIF3F binds EIF4E. 4 / 4
3 | 1
sparser
"Further co-immunoprecipitation analyses showed that the presence of CERES promotes eIF3f interaction with eIF4E1 ( xref ), suggesting that, as in the case of eIF4A2, CERES acts as a molecular bridge able to support eIF3 binding to eIF4E containing complexes."
31819221
biogrid
No evidence text available
24981860
biogrid
No evidence text available
30573685
biogrid
No evidence text available
19615732
EIF3F affects sCLU
| 4
EIF3F inhibits sCLU.
| 2
EIF3F inhibits sCLU. 2 / 2
| 2
reach
"Therefore, eIF3f inhibits cancer cell growth and induces apoptosis by inhibiting sCLU function."
26988917
reach
"The data also suggest that eIF3f inhibits cancer cell growth and induces apoptosis by blocking the function of sCLU, thereby suppressing the inactivation of p53 and Bax as well as the Akt and ERK pathways."
26988917
EIF3F decreases the amount of sCLU.
| 2
EIF3F decreases the amount of sCLU. 2 / 2
| 2
reach
"These results suggest that eIF3f might interact with CLU protein to reduce the expression of sCLU in both intracellular and extracellular compartments by preventing structural changes."
26988917
reach
"Therefore, we hypothesized that eIF3f disrupts the stability of the Ku70 and Bax complex because eIF3f binds to sCLU to deplete the expression of sCLU."
26988917
EIF3F affects mTORC1
| 4
EIF3F binds mTORC1.
| 2
EIF3F binds mTORC1. 2 / 2
| 2
reach
"They also observed that rapamycin treatment destabilizes the mTORC1 and eIF3f interaction in differentiated myotubes, and that ablation of eIF3f in muscle cells prevents mTORC1 activity and phosphorylation of S6K1, rpS6 and 4E-BP1 [XREF_BIBR]."
23354061
reach
"However, although sepsis does not decrease the total eIF3f protein in muscle, the amount of eIF3f bound to mTORC1 (e.g., raptor) was reduced."
21487027
EIF3F inhibits mTORC1.
| 1
EIF3F inhibits mTORC1. 1 / 1
| 1
reach
"Ablation of eIF3f in muscle cells prevents mTORC1 activity, phosphorylation of S6K1, rpS6 and 4E-PB1."
20126553
EIF3F dephosphorylates mTORC1.
| 1
EIF3F leads to the dephosphorylation of mTORC1. 1 / 1
| 1
reach
"They also observed that rapamycin treatment destabilizes the mTORC1 and eIF3f interaction in differentiated myotubes, and that ablation of eIF3f in muscle cells prevents mTORC1 activity and phosphorylation of S6K1, rpS6 and 4E-BP1 [XREF_BIBR]."
23354061
EIF3F affects growth
| 4
EIF3F inhibits growth. 4 / 4
| 4
sparser
"We next explored whether eIF3f inhibits tumor growth in vivo ."
26988917
sparser
"The data also suggest that eIF3f inhibits cancer cell growth and induces apoptosis by blocking the function of sCLU, thereby suppressing the inactivation of p53 and Bax as well as the Akt and ERK pathways."
26988917
sparser
"EIF3f inhibits tumor growth in vivo ."
26988917
sparser
"Therefore, eIF3f inhibits cancer cell growth and induces apoptosis by inhibiting sCLU function."
26988917
EIF3F affects cell death
| 4
EIF3F activates cell death. 4 / 4
| 4
reach
"MD11 mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death."
31026345
reach
"MD 11 -mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death."
26052528
reach
"While the lacking of literature does not allow formulate any hypothesis on glioblastoma cells and eIF3f correlation, our result on C2C12 confirms that overexpression of eIF3f does not induce cell death but it acts as " cell growth enhancer " instead of " death executer. ""
26052528
reach
"To determine whether exogenously administered eIF3f proteins were able to compensate the loss of endogenous eIF3f and induce cancer cell death, we analyzed the therapeutic action of MD 11 -eIF3f in several tumor cells."
26052528
EIF3F affects RAN
| 4
EIF3F activates RAN.
| 3
EIF3F activates RAN. 3 / 3
| 3
reach
"The eukaryotic translation initiation factor eIF3F has also been reported to modulate RAN translation [3]."
34953315
reach
"Additionally, knockdown of the eukaryotic translation initiation factor eIF3F in cells reduces steady-state levels of SCA8 polySer and other RAN proteins."
30206144
reach
"EIF3F has previously been shown to modulate RAN translation in cellular reporters (Ayhan et al., 2018)."
37352983
EIF3F increases the amount of RAN.
| 1
EIF3F increases the amount of RAN. 1 / 1
| 1
reach
"Overexpression of eIF3F in cells increases RAN protein levels, whereas knocking down eIF3F significantly reduced polySer, polyAla, and polyGP RAN proteins [3]."
34953315
EIF3F affects PRRC2B
4 |
EIF3F binds PRRC2B. 4 / 4
4 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
EIF3F affects NOTCH1
1 2 |
EIF3F binds NOTCH1.
2 |
EIF3F binds NOTCH1. 2 / 2
2 |
biogrid
No evidence text available
21124883
biogrid
No evidence text available
21124883
EIF3F activates NOTCH1.
1 |
EIF3F activates NOTCH1. 1 / 2
1 |
signor
"The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor."
21124883
EIF3F affects GLE1
1 | 2
GLE1 binds EIF3F. 3 / 4
1 | 2
biogrid
No evidence text available
18724935
reach
"Our previous studies found that hGle1 localization at the NPC is dependent on interactions with both hNup155 and hCG1, and that hGle1 interacts with the translation initiation factor eIF3f."
24243016
reach
"While a direct role for hGle1 in translation initiation or translation termination has not been documented to date, it has been shown that hGle1 directly interacts with eIF3f, a subunit of the translation initiation machinery."
24275432
EIF3F affects FBXW7
1 | 3
EIF3F deubiquitinates FBXW7.
| 2
EIF3F deubiquitinates FBXW7. 2 / 2
| 2
reach
"Moreover, we uncover that PHGDH is a novel substrate of GSK3β/FBXW7β and eIF3f could deubiquitinate FBXW7β‐mediated ubiquitination of PHGDH."
37544925
reach
"39 Our study identified PHGDH as a novel substrate of FBXW7β and implies that eIF3f may participate in deubiquitinating FBXW7 targets.Wnt signaling is a pivotal oncogenic pathway in CRC, and targeting this pathway for therapeutic strategy is very appealing."
37544925
EIF3F binds FBXW7.
1 | 1
FBXW7 binds EIF3F. 2 / 2
1 | 1
reach
"Further, co‐IP result confirmed the interaction between eIF3f and FBXW7β suggesting that eIF3f, FBXW7 and PHGDH may form a complex (Figure S3H, Supporting Information)."
37544925
biogrid
No evidence text available
29346117
EIF3F affects EIF4E
3 | 1
EIF3F binds EIF4E. 4 / 4
3 | 1
sparser
"Further co-immunoprecipitation analyses showed that the presence of CERES promotes eIF3f interaction with eIF4E1 ( xref ), suggesting that, as in the case of eIF4A2, CERES acts as a molecular bridge able to support eIF3 binding to eIF4E containing complexes."
31819221
biogrid
No evidence text available
24981860
biogrid
No evidence text available
30573685
biogrid
No evidence text available
19615732
EIF3F affects DTX1
3 | 1
EIF3F binds DTX1. 4 / 4
3 | 1
reach
"These results show that the tripartite interaction between Notch, DTX, and eIF3f occurs preferentially with activated, membrane associated, but gamma-secretase unprocessed, forms of Notch."
21124883
biogrid
No evidence text available
21124883
biogrid
No evidence text available
21124883
biogrid
No evidence text available
21124883
Rep affects EIF3F
3 |
Rep binds EIF3F. 3 / 3
3 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
32680882
biogrid
No evidence text available
36180527
Heterogeneous nuclear ribonucleoprotein affects EIF3F
| 3
EIF3F binds heterogeneous nuclear ribonucleoprotein. 2 / 2
| 2
sparser
"EIF3f interacts with heterogeneous nuclear ribonucleoprotein (hnRNP) and induces rRNA degradation by interfering with the interaction between hnRNP and rRNA, which subsequently inhibits protein translation [ xref , xref ]."
26988917
sparser
"EIF3f can also interact with heterogeneous nuclear ribonucleoprotein (hnRNP) and induce rRNA degeneration, which can inhibit protein translation [ xref ]."
32498447
RNA-binding binds EIF3F and heterogeneous nuclear ribonucleoprotein. 1 / 1
| 1
sparser
"In this model, rRNA degradation is carried out by direct interaction between eIF3f and heterogeneous nuclear ribonucleoprotein (hnRNP) K, a RNA-binding protein required for maintaining rRNA stability [ xref ]."
| PMC
Cadmium dichloride increases the amount of EIF3F. 3 / 3
3 |
ctd
No evidence text available
23741332
ctd
No evidence text available
26472689
ctd
No evidence text available
35301059
TPGS1 affects EIF3F
3 |
EIF3F binds TPGS1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
TIMM29 affects EIF3F
3 |
EIF3F binds TIMM29. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STING1 affects EIF3F
| 1 2
STING1 binds EIF3F. 3 / 3
| 1 2
reach
"In uninfected cells or the early phase of infection, iRhom2 acts as an adaptor protein, promoting the interaction of STING and EIF3S5, a deubiquitinating enzyme, thereby inhibiting the degradation of STING (figure 2) [18]."
30890028
sparser
"In uninfected cells or the early phase of infection, iRhom2 acts as an adaptor protein, promoting the interaction of STING and EIF3S5, a deubiquitinating enzyme, thereby inhibiting the degradation of STING ( xref ) [ xref ]."
30890028
sparser
"EIF3S5 is recruited by inactive rhomboid protein 2 (iRhom2) and interacts with STING ( xref )."
36579404
SLU7 affects CDK19
| 3
EIF3F binds SLU7 and CDK19. 3 / 3
| 3
sparser
"Together these results show that CDK11 and 9G8 both interact with eIF3f."
19854136
sparser
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3’ end processing of the HIV-1 pre-mRNA in a sequence-specific manner."
19854136
sparser
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
19854136
RPTOR affects EIF3F
| 1 2
MTOR binds RPTOR and EIF3F. 2 / 2
| 2
sparser
"Mutation of the C-Terminal Lysines in eIF3f Increases Interaction with mTOR and Raptor."
20126553
sparser
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
RPTOR binds EIF3F. 1 / 1
| 1
reach
"Indeed, mTOR/raptor complex bound to the scaffold protein eIF3f during muscle hypertrophy, which phosphorylated S6K1 and regulated downstream effectors of mTOR (51)."
26109581
RPS6KB1 affects MTOR
| 3
MTOR binds RPS6KB1 and EIF3F. 3 / 3
| 3
sparser
"MTOR and S6K1 physically interact with two different domains of eIF3f."
20126553
sparser
"Our group proposed that S6K1 and mTOR physically interact with two different domains of eIF3f in muscle cells."
23769948
sparser
"This idea is supported by studies which have shown that eIF3f physically interacts with mTOR and p70 S6K ( xref , xref )."
20154608
N affects EIF3F
3 |
N binds EIF3F. 3 / 3
3 |
biogrid
No evidence text available
34578187
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
38043095
MTOR affects RPS6KB1
| 3
MTOR binds RPS6KB1 and EIF3F. 3 / 3
| 3
sparser
"MTOR and S6K1 physically interact with two different domains of eIF3f."
20126553
sparser
"Our group proposed that S6K1 and mTOR physically interact with two different domains of eIF3f in muscle cells."
23769948
sparser
"This idea is supported by studies which have shown that eIF3f physically interacts with mTOR and p70 S6K ( xref , xref )."
20154608
LRRC49 affects EIF3F
3 |
EIF3F binds LRRC49. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
JOSD1 affects EIF3F
3 |
EIF3F binds JOSD1. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
FCGRT affects EIF3F
| 3
EIF3F binds FCGRT. 3 / 3
| 3
sparser
"EIF3f interacts with the α-chain of sCLU."
26988917
sparser
"Data revealed that eIF3f binds with the α-chain of sCLU encoded by amino acids 1-227 (Figure xref )."
26988917
sparser
"Interestingly, eif3f interacts with α-chain but PACAP binds with β-chain of CLU."
26988917
FBXW7 affects EIF3F
1 | 2
FBXW7 binds EIF3F.
1 | 1
FBXW7 binds EIF3F. 2 / 2
1 | 1
reach
"Further, co‐IP result confirmed the interaction between eIF3f and FBXW7β suggesting that eIF3f, FBXW7 and PHGDH may form a complex (Figure S3H, Supporting Information)."
37544925
biogrid
No evidence text available
29346117
FBXW7 inhibits EIF3F.
| 1
FBXW7 inhibits EIF3F. 1 / 1
| 1
reach
"Immunoblotting revealed that overexpression of FBXW7β increased the ubiquitination level of PHGDH and this effect could be reversed in the presence of eIF3f (Figure 3G)."
37544925
ESR1 affects EIF3F
3 |
EIF3F binds ESR1. 3 / 3
3 |
biogrid
No evidence text available
31527615
biogrid
No evidence text available
30573685
biogrid
No evidence text available
30573685
EIF4B affects EIF3F
3 |
EIF3F binds EIF4B. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
29228324
biogrid
No evidence text available
31527668
EIF4A2 affects EIF3F
3 |
EIF3F binds EIF4A2. 3 / 3
3 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
19615732
biogrid
No evidence text available
29395067
EIF3F affects rep
3 |
Rep binds EIF3F. 3 / 3
3 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
32680882
biogrid
No evidence text available
36180527
EIF3F affects heterogeneous nuclear ribonucleoprotein
| 3
EIF3F binds heterogeneous nuclear ribonucleoprotein. 2 / 2
| 2
sparser
"EIF3f interacts with heterogeneous nuclear ribonucleoprotein (hnRNP) and induces rRNA degradation by interfering with the interaction between hnRNP and rRNA, which subsequently inhibits protein translation [ xref , xref ]."
26988917
sparser
"EIF3f can also interact with heterogeneous nuclear ribonucleoprotein (hnRNP) and induce rRNA degeneration, which can inhibit protein translation [ xref ]."
32498447
RNA-binding binds EIF3F and heterogeneous nuclear ribonucleoprotein. 1 / 1
| 1
sparser
"In this model, rRNA degradation is carried out by direct interaction between eIF3f and heterogeneous nuclear ribonucleoprotein (hnRNP) K, a RNA-binding protein required for maintaining rRNA stability [ xref ]."
| PMC
EIF3F affects TPGS1
3 |
EIF3F binds TPGS1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
EIF3F affects TIMM29
3 |
EIF3F binds TIMM29. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
EIF3F affects RPTOR
| 1 2
MTOR binds RPTOR and EIF3F. 2 / 2
| 2
sparser
"Mutation of the C-Terminal Lysines in eIF3f Increases Interaction with mTOR and Raptor."
20126553
sparser
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
RPTOR binds EIF3F. 1 / 1
| 1
reach
"Indeed, mTOR/raptor complex bound to the scaffold protein eIF3f during muscle hypertrophy, which phosphorylated S6K1 and regulated downstream effectors of mTOR (51)."
26109581
EIF3F affects Neoplasms
| 2
EIF3F inhibits Neoplasms. 2 / 3
| 2
reach
"Another, the expression of eIF3f is downregulated in many human tumors, the overexpression of eIF3f inhibits cell proliferation, and induces apoptosis in tumor cells ( Doldan et al., 2008; Shi et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25888243
reach
"Studies showed that high expression of eIF3f correlated with advanced gastric tumor stages and likelihood of recurrence 31 just like CRC, while eIF3f expression is significantly decreased in human pancreatic adenocarcinoma and melanoma, 32 and eIF3f inhibits tumor growth in cervical cancer model."
37544925
EIF3F affects N
3 |
N binds EIF3F. 3 / 3
3 |
biogrid
No evidence text available
34578187
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
38043095
EIF3F affects MTOR, and RPS6KB1
| 3
MTOR binds RPS6KB1 and EIF3F. 3 / 3
| 3
sparser
"MTOR and S6K1 physically interact with two different domains of eIF3f."
20126553
sparser
"Our group proposed that S6K1 and mTOR physically interact with two different domains of eIF3f in muscle cells."
23769948
sparser
"This idea is supported by studies which have shown that eIF3f physically interacts with mTOR and p70 S6K ( xref , xref )."
20154608
EIF3F affects LRRC49
3 |
EIF3F binds LRRC49. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
EIF3F affects JOSD1
3 |
EIF3F binds JOSD1. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EIF3F affects FCGRT
| 3
EIF3F binds FCGRT. 3 / 3
| 3
sparser
"EIF3f interacts with the α-chain of sCLU."
26988917
sparser
"Data revealed that eIF3f binds with the α-chain of sCLU encoded by amino acids 1-227 (Figure xref )."
26988917
sparser
"Interestingly, eif3f interacts with α-chain but PACAP binds with β-chain of CLU."
26988917
EIF3F affects Eif3a
2 | 1
EIF3F binds Eif3a.
2 |
Eif3a binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
20360068
EIF3F inhibits Eif3a.
| 1
EIF3F inhibits Eif3a. 1 / 1
| 1
reach
"It is likely that the loss of eIF3f in cancer cells induces increased eIF3 activity, which in turn stimulates translation of specific mRNAs encoding proteins involved in cell proliferation."
26052528
EIF3F affects ESR1
3 |
EIF3F binds ESR1. 3 / 3
3 |
biogrid
No evidence text available
31527615
biogrid
No evidence text available
30573685
biogrid
No evidence text available
30573685
EIF3F affects EIF4B
3 |
EIF3F binds EIF4B. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
29228324
biogrid
No evidence text available
31527668
EIF3F affects EIF4A2
3 |
EIF3F binds EIF4A2. 3 / 3
3 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
19615732
biogrid
No evidence text available
29395067
EIF3F affects EEF1A1
2 1 |
EIF3F binds EEF1A1. 3 / 3
2 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
biogrid
No evidence text available
31527668
EIF3F affects E6
3 |
E6 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
22898364
biogrid
No evidence text available
22898364
E6 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
22898364
EIF3F affects DTrc8
| 3
DTrc8 binds EIF3F. 3 / 3
| 3
reach
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
reach
"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 (XREF_FIG)."
20068067
reach
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
EIF3F affects DDX3X
3 |
DDX3X binds EIF3F. 3 / 3
3 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
18628297
biogrid
No evidence text available
31527668
EIF3F affects Cell Survival
| 3
reach
"Indeed, eIF3f KD exhibited growth suppression, while serine supplement 26 could rescue the decreased cell viability caused by eIF3f KD (Figure 5A and Figure S5A, Supporting Information)."
37544925
reach
"These assays also showed that EIF3F reduced the cell viability and PSMD14 improved cell viability under H/R treatment (Figure 1A)."
39897566
reach
"Cell growth was monitored and, as shown, silencing eIF3f either by antisense or by siRNA significantly decreased cell viability."
20462454
EIF3F affects Caspase
| 2 1
Caspase binds EIF3F. 2 / 2
| 1 1
reach
"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [XREF_BIBR] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation."
23354061
sparser
"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase-processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [ xref ] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation (Fig.  xref )."
23354061
Caspase binds EIF3F and Thr-119. 1 / 1
| 1
reach
"Moreover, caspase processed isoform of the cell division kinase 11 (Cdk11 p46) binds and phosphorylates eIF3f at Ser 46 and Thr 119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation."
23769948
EIF3F affects CSTPP1
3 |
EIF3F binds CSTPP1. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EIF3F affects CSNK2A2
3 |
EIF3F binds CSNK2A2. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
32707033
biogrid
No evidence text available
36736316
EIF3F affects CSNK2A1
3 |
EIF3F binds CSNK2A1. 3 / 3
3 |
biogrid
No evidence text available
32707033
biogrid
No evidence text available
36736316
biogrid
No evidence text available
19615732
EIF3F affects CDK11A
3 |
EIF3F binds CDK11A. 3 / 3
3 |
biogrid
No evidence text available
36736316
biogrid
No evidence text available
12446680
biogrid
No evidence text available
12446680
EIF3F affects BAX
| 2
EIF3F activates BAX.
| 1
EIF3F activates BAX. 1 / 2
| 1
reach
"EIF3f overexpression activates p53 and Bax and inhibits Akt and ERK signaling."
26988917
EIF3F increases the amount of BAX.
| 1
Modified EIF3F increases the amount of BAX. 1 / 1
| 1
reach
"Consistent with previous reports, the current study demonstrated that the overexpression of eIF3f enhanced p53, p21, and activated Bax levels in a time dependent manner in HeLa cervical cancer cells."
26988917
EIF3F affects ADRA1B
1 |
EIF3F binds ADRA1B. 1 / 3
1 |
biogrid
No evidence text available
26497985
EIF3F affects ACSL4
| 2 1
EIF3F binds ACSL4. 2 / 2
| 1 1
sparser
"In addition, phosphorylated eIF3f enhanced the interaction between eIF3f and ACSL4."
40154622
reach
"In addition, phosphorylated eIF3f enhanced the interaction between eIF3f and ACSL4."
40154622
EIF3F binds ACSL4 and K48. 1 / 1
| 1
reach
"EIF3f directly interacted with and stabilised long chain acyl CoA synthetase 4 (ACSL4) through K48-linked deubiquitination, promoting fatty acid biosynthesis (FAB) and tumour malignancy."
40154622
EIF3A affects EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, and EIF3J
3 |
EIF3J binds EIF3A, EIF3I, EIF3H, EIF3G, EIF3F, EIF3E, EIF3D, EIF3C, and EIF3B. 3 / 3
3 |
hprd
No evidence text available
9822659
hprd
No evidence text available
8995410
hprd
No evidence text available
8995409
EEF1A1 affects EIF3F
2 1 |
EIF3F binds EEF1A1. 3 / 3
2 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
biogrid
No evidence text available
31527668
E6 affects EIF3F
3 |
E6 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
22898364
biogrid
No evidence text available
22898364
E6 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
22898364
DTrc8 affects EIF3F
| 3
DTrc8 binds EIF3F. 3 / 3
| 3
reach
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
reach
"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 (XREF_FIG)."
20068067
reach
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
DND1 affects EIF3F
| 2 1
DND1 activates EIF3F.
| 2
DND1 activates EIF3F. 2 / 2
| 2
reach
"Consistently, in Xenopus, Dnd1 was shown to prevent interaction of translational repressor eIF3f with nanos mRNA ."
37463577
reach
"Similarly, association of repressors of nanos3 translation in Dnd1-depleted germ cells could maintain the transcript at the core of the granule.Consistently, in Xenopus, Dnd1 was shown to prevent interaction of translational repressor eIF3f with nanos mRNA ."
37461638
DND1 binds EIF3F.
| 1
DND1 binds EIF3F. 1 / 1
| 1
sparser
"We previously found that Dnd1 directly interacts with eIF3f, and through it, the whole eIF3 complex, which is required to initiate translation ( xref )."
30230100
DDX3X affects EIF3F
3 |
DDX3X binds EIF3F. 3 / 3
3 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
18628297
biogrid
No evidence text available
31527668
CSTPP1 affects EIF3F
3 |
EIF3F binds CSTPP1. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
CSNK2A2 affects EIF3F
3 |
EIF3F binds CSNK2A2. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
32707033
biogrid
No evidence text available
36736316
CSNK2A1 affects EIF3F
3 |
EIF3F binds CSNK2A1. 3 / 3
3 |
biogrid
No evidence text available
32707033
biogrid
No evidence text available
36736316
biogrid
No evidence text available
19615732
CDK19 affects SLU7
| 3
EIF3F binds SLU7 and CDK19. 3 / 3
| 3
sparser
"Together these results show that CDK11 and 9G8 both interact with eIF3f."
19854136
sparser
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3’ end processing of the HIV-1 pre-mRNA in a sequence-specific manner."
19854136
sparser
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
19854136
CDK11p46 kinase affects EIF3F
| 3
CDK11p46 kinase phosphorylates EIF3F. 3 / 3
| 3
rlimsp
"After prolonged stress-induced apoptosis, Mss4 is downregulated, leading to a release of eIF3f, which is phosphorylated by the CDK11p46 kinase and the translation initiation results inhibite."
23354061
rlimsp
"If a certain threshold of stress is crossed, Mss4 is downregulated, leading to a release of eIF3f, which can now be phosphorylated by the caspase-activated CDK11p46 kinase, incorporated into the eIF3 protein compound, which in turn results in inhibition of translation and induction of apoptosis (right picture."
22495352
rlimsp
"Furthermore, during apoptosis eIF3f has been shown to be bound and phosphorylated by CDK11p46 kinase."
22495352
ADRA1B affects EIF3F
1 |
EIF3F binds ADRA1B. 1 / 3
1 |
biogrid
No evidence text available
26497985
ACSL4 affects EIF3F
| 2 1
EIF3F binds ACSL4. 2 / 2
| 1 1
sparser
"In addition, phosphorylated eIF3f enhanced the interaction between eIF3f and ACSL4."
40154622
reach
"In addition, phosphorylated eIF3f enhanced the interaction between eIF3f and ACSL4."
40154622
EIF3F binds ACSL4 and K48. 1 / 1
| 1
reach
"EIF3f directly interacted with and stabilised long chain acyl CoA synthetase 4 (ACSL4) through K48-linked deubiquitination, promoting fatty acid biosynthesis (FAB) and tumour malignancy."
40154622
2,3,7,8-tetrachlorodibenzodioxine increases the amount of EIF3F.
2 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of EIF3F. 2 / 2
2 |
ctd
No evidence text available
33387578
ctd
No evidence text available
17942748
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of EIF3F.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
34747641
MTORC1 affects EIF3F
| 2
EIF3F binds mTORC1. 2 / 2
| 2
reach
"They also observed that rapamycin treatment destabilizes the mTORC1 and eIF3f interaction in differentiated myotubes, and that ablation of eIF3f in muscle cells prevents mTORC1 activity and phosphorylation of S6K1, rpS6 and 4E-BP1 [XREF_BIBR]."
23354061
reach
"However, although sepsis does not decrease the total eIF3f protein in muscle, the amount of eIF3f bound to mTORC1 (e.g., raptor) was reduced."
21487027
Benzo[a]pyrene affects EIF3F
2 |
Benzo[a]pyrene methylates EIF3F.
1 |
Benzo[a]pyrene methylates EIF3F. 1 / 1
1 |
ctd
No evidence text available
27901495
Benzo[a]pyrene increases the amount of EIF3F.
1 |
Benzo[a]pyrene increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
22228805
Wnt affects EIF3F
| 2
Wnt increases the amount of EIF3F. 2 / 2
| 2
reach
"Furthermore, expression of Wnt signaling mediator β‐catenin/TCF4 indeed upregulated eIF3f gene expression (Figure 6E,F)."
37544925
reach
"Collectively, these results validated the oncogenic role of eIF3f and that eIF3f promoted CRC progression via SGOC pathway reprogramming by regulating PHGDH expression.2.6 Wnt Signaling Transcriptionally Upregulates the Expression of eIF3f."
37544925
UBE2A affects EIF3F
2 |
UBE2A binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
28031328
biogrid
No evidence text available
28031328
TUBB3 affects EIF3F
2 |
EIF3F binds TUBB3. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
TRIM28 affects EIF3F
2 |
TRIM28 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
31527668
biogrid
No evidence text available
29955894
TP53 affects EIF3F
2 |
TP53 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
29653964
biogrid
No evidence text available
29653964
TIMM10B affects EIF3F
2 |
TIMM10B binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
32296183
SMAD9 affects EIF3F
1 1 |
SMAD9 binds EIF3F. 2 / 2
1 1 |
hprd
No evidence text available
15231748
biogrid
No evidence text available
15231748
SDeltaC affects EIF3F
| 2
SDeltaC binds EIF3F. 2 / 2
| 2
reach
"Co-immunoprecipitation experiments were performed to further test the interaction between SDeltaC and eIF3f."
18231581
reach
"These results substantiate the conclusion that SDeltaC could interact with eIF3f and further demonstrate that the two proteins could form stable complexes in vitro."
18231581
RPTOR affects MTOR
| 2
MTOR binds RPTOR and EIF3F. 2 / 2
| 2
sparser
"Mutation of the C-Terminal Lysines in eIF3f Increases Interaction with mTOR and Raptor."
20126553
sparser
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
RPL34 affects EIF3F
| 2
RPL34 increases the amount of EIF3F. 2 / 2
| 2
reach
"Knockdown of RPL34 mRNA significantly suppressed EIF3A and EIF3F expression and significantly up-regulated FAU expression in the Saos-2 cell line, but there were no remarkable differences in the relative expression in the EIF3G, UBA52, and UBC genes."
35116824
reach
"Moreover, knockdown of RPL34 mRNA significantly suppresses EIF3A and EIF3F expression and significantly up-regulated FAU expression in Saos-2 cell lines, while the expression of EIF3G, UBA52, and UBC had no significant difference."
35116824
RNF139 affects EIF3H
| 2
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
RHBDF2 affects EIF3F
| 2
RHBDF2 inhibits EIF3F.
| 1
RHBDF2 inhibits EIF3F. 1 / 1
| 1
reach
"For instance, iRhom2 could regulate the stability of PLC or other proteins involved in the MHC-I antigen presentation pathway, in a similar manner to its regulation of ubiquitination and therefore stability of STING and VISA [15, 16] Indeed, iRhom2 prevents proteasomal degradation of STING by recruiting the deubiquitinase EIF3S5 that removes K48-linked polyubiquitin chains from the protein."
38570362
RHBDF2 deubiquitinates EIF3F.
| 1
RHBDF2 leads to the deubiquitination of EIF3F. 1 / 1
| 1
reach
"EIF3S5 deubiquitination is produced after its recruitment by iRhom2 during STING trafficking, increasing its stability during this crucial step in the activation mechanism [42]."
37240378
RBX1 affects EIF3F
2 |
RBX1 decreases the amount of EIF3F.
1 |
RBX1 bound to SKP1 and CUL1 decreases the amount of EIF3F. 1 / 1
1 |
signor
"Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome."
18354498
RBX1 binds EIF3F.
1 |
RBX1 bound to SKP1 and CUL1 binds EIF3F. 1 / 1
1 |
signor
"Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome."
18354498
Piwil1 affects ELAVL1
| 2
Piwil1 binds EIF3F and ELAVL1. 2 / 2
| 2
sparser
"We next examined whether HuR associates with MIWI and eIF3f."
31835033
sparser
"Unlike 293T cells, mouse testes contain active piRNAs, and indeed, we detected significant association of endogenous HuR with both MIWI and eIF3f in mouse testes ( xref )."
31835033
PTN affects EIF3F
1 1 |
EIF3F binds PTN. 2 / 2
1 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
PSMD7 affects EIF3F
| 2
EIF3F binds PSMD7. 2 / 2
| 2
sparser
"MAFbx/atrogin-1 interacts with the Mov34 domain of eIF3f and promotes its ubiquitination resulting in proteasome-mediated degradation of eIF3f during muscle wasting ( xref ) ( xref )."
23769948
sparser
"LCD in MAFbx is thought to be critical for interaction with the MOV34 domain of eIF3f [12] , the EGLQALLR motif in MyoD [6] and the Forkhead domain of the transcription factors Foxo1 and 3A [18,19] ."
22249105
PRKN affects EIF3F
2 |
PRKN binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
35509820
biogrid
No evidence text available
35256949
NUP155 affects EIF3F
| 1 1
NUP42 binds NUP155 and EIF3F. 1 / 1
| 1
sparser
"Furthermore, the hCG1, Nup155 and eIF3f interactions were not perturbed by the PFQ insertion ( xref )."
24243016
NUP155 binds EIF3F. 1 / 1
| 1
reach
"Furthermore, the hCG1, Nup155 and eIF3f interactions were not perturbed by the PFQ insertion (XREF_SUPPLEMENTARY)."
24243016
NOTCH1 affects EIF3F
2 |
EIF3F binds NOTCH1. 2 / 2
2 |
biogrid
No evidence text available
21124883
biogrid
No evidence text available
21124883
NIPSNAP2 affects EIF3F
2 |
biogrid
No evidence text available
35305106
biogrid
No evidence text available
35305106
MYC affects EIF3F
2 |
MYC binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
36424410
biogrid
No evidence text available
29467282
MTOR affects RPTOR
| 2
MTOR binds RPTOR and EIF3F. 2 / 2
| 2
sparser
"Mutation of the C-Terminal Lysines in eIF3f Increases Interaction with mTOR and Raptor."
20126553
sparser
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
MAEL affects EIF3F
2 |
MAEL binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
24189637
biogrid
No evidence text available
24189637
HUWE1 affects EIF3F
2 |
HUWE1 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
25147182
biogrid
No evidence text available
37167062
HAX1 affects EIF3F
1 1 |
EIF3F binds HAX1. 2 / 2
1 1 |
biogrid
No evidence text available
16189514
hprd
No evidence text available
16189514
FBXO33 affects EIF3F
1 1 |
FBXO33 ubiquitinates EIF3F. 2 / 2
1 1 |
ubibrowser
"UbiNet 2.0"
18354498
signor
"Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome."
18354498
Eif3a affects EIF3F
2 |
Eif3a binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
20360068
EZH2 affects EIF3F
2 |
EZH2 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
27634302
biogrid
No evidence text available
36517590
ELAVL1 affects Piwil1
| 2
Piwil1 binds EIF3F and ELAVL1. 2 / 2
| 2
sparser
"We next examined whether HuR associates with MIWI and eIF3f."
31835033
sparser
"Unlike 293T cells, mouse testes contain active piRNAs, and indeed, we detected significant association of endogenous HuR with both MIWI and eIF3f in mouse testes ( xref )."
31835033
EIF4G3 affects EIF3F
2 |
EIF3F binds EIF4G3. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
24981860
EIF4E2 affects EIF3F
2 |
EIF3F binds EIF4E2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
EIF3H affects RNF139
| 2
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
EIF3F affects tumor growth
| 1
EIF3F inhibits tumor growth. 1 / 2
| 1
eidos
"EIF3f also reduces tumor growth by interacting with the secretory heterodimeric glycoprotein clusterin and interrupting its anti-apoptotic property [ 162 ] ."
| PMC
EIF3F affects ribosomal RNA
| 2
EIF3F inhibits ribosomal RNA. 2 / 2
| 2
eidos
"Mechanistically , the authors found that eIF3f inhibits both cap-dependent and cap-independent translation and that eIF3f promotes rRNA degradation through direct interaction with heterogeneous nuclear ribonucleoprotein K ( Wen et al ., 2012 ) ."
23769948
eidos
"Notably , the eIF3f level was reportedly reduced in pancreatic cancer , and overexpression of eIF3f in pancreatic cancer cells resulted in apoptosis ; 33moreover , eIF3f promoted rRNA degradation and inhibited translation.34eIF3f has been shown to act as a tumor suppressor in melanoma.35 ,36 In patients with gastric cancer , reduced expression of eIF3f was associated with poor prognosis , and eIF3f presumably plays an important role in gastric cancer recurrence.37-39However , it remains controversial whether eIF3f acts as an oncogene or a suppressor ."
32440143
EIF3F affects replication
| 2
EIF3F inhibits replication. 2 / 2
| 2
sparser
"In addition to inhibiting host translation, eIF3f can inhibit HIV replication by specifically impeding the 3′ end processing of HIV-1 mRNAs ( xref )."
29173589
sparser
"In addition, it has been shown that HIV-1 replication is inhibited by eIF3f, through its proline- and alanine-rich N-terminal region [ xref , xref ]."
26497985
EIF3F affects protein synthesis
| 2
EIF3F inhibits protein synthesis. 2 / 2
| 2
sparser
"Furthermore, in mammalian cells, eIF3f inhibits protein synthesis at the translational level and not by affecting mRNA levels [ xref ]."
23354061
sparser
"Several studies show that eIF3f inhibits protein synthesis [ xref , xref ]."
20462454
EIF3F affects expression
| 2
EIF3F inhibits expression. 2 / 2
| 2
sparser
"Therefore, we assessed how eIF3f inhibits p53 expression using qRT-PCR and cycloheximide (CHX) assays."
26988917
sparser
"The previous figures show that eIF3f inhibited CLU expression and induced apoptotic signal."
26988917
EIF3F affects cytokinesis
| 2
EIF3F inhibits cytokinesis. 2 / 2
| 2
reach
"In our current study, we found evidence that stable knockdown of eIF3f in normal human pancreatic ductal epithelial cells increased cell size, nuclear pleomorphism, cytokinesis defects, cell proliferation, clonogenicity, apoptotic resistance, migration, and formation of 3-dimensional irregular masses."
22457825
reach
"We also showed that silencing of eIF3f promotes both cap dependent and cap-independent and internal ribosome entry site (IRES)-dependent translation and cytokinesis defects."
22457825
EIF3F affects cell migration
| 1 1
EIF3F activates cell migration. 2 / 2
| 1 1
reach
"Overexpression of EIF3F in these cells has been shown to enhance cell migration and invasion by interacting with STAT3 and modulating a series of genes associated with metastasis [37]."
39934701
eidos
"EIF3F reprograms the proteome of mice orthotopic human lung tumors and promotes cell migration ."
31527668
EIF3F affects UBE2A
2 |
UBE2A binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
28031328
biogrid
No evidence text available
28031328
EIF3F affects TUBB3
2 |
EIF3F binds TUBB3. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
EIF3F affects TRIM28
2 |
TRIM28 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
31527668
biogrid
No evidence text available
29955894
EIF3F affects TIMM10B
2 |
TIMM10B binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
32296183
EIF3F affects SMAD9
1 1 |
SMAD9 binds EIF3F. 2 / 2
1 1 |
hprd
No evidence text available
15231748
biogrid
No evidence text available
15231748
EIF3F affects SDeltaC
| 2
SDeltaC binds EIF3F. 2 / 2
| 2
reach
"Co-immunoprecipitation experiments were performed to further test the interaction between SDeltaC and eIF3f."
18231581
reach
"These results substantiate the conclusion that SDeltaC could interact with eIF3f and further demonstrate that the two proteins could form stable complexes in vitro."
18231581
EIF3F affects RPS17
2 |
EIF3F binds RPS17.
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L binds RPS17 bound to RPSA, RPS2, RPS4Y1, RPS3, RPS12, RPS19, RPS27, RPS9, RPS5, RPS10, RPS20, RPS3A, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS23, RPS18, RPS29, RPS13, RPS11, RPS4X, RPS6, RPS15, RPS24, RPS25, RPS26, RPS28, FAU, RPS27A, RPS21, RPS27L, and RPS4Y2. 1 / 1
1 |
signor
"EIF3 binds 40S and inhibits the association of 60S. Structural analysis suggests that eIF3 performs this scaffolding function by binding to the 40S subunit on its solvent-exposed surface rather than on its interface with the 60S subunit, where the decoding sites exist. This location of eIF3 seems ideally suited for its other proposed regulatory functions, including reinitiating translation on polycistronic mRNAs and acting as a receptor for protein kinases that control protein synthesis."
16920360
EIF3F activates RPS17.
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L activates RPS17 bound to RPSA, RPS2, RPS4Y1, RPS3, RPS12, RPS19, RPS27, RPS9, RPS5, RPS10, RPS20, RPS3A, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS23, RPS18, RPS29, RPS13, RPS11, RPS4X, RPS6, RPS15, RPS24, RPS25, RPS26, RPS28, FAU, RPS27A, RPS21, RPS27L, and RPS4Y2. 1 / 1
1 |
signor
"EIF3 binds 40S and inhibits the association of 60S. Structural analysis suggests that eIF3 performs this scaffolding function by binding to the 40S subunit on its solvent-exposed surface rather than on its interface with the 60S subunit, where the decoding sites exist. This location of eIF3 seems ideally suited for its other proposed regulatory functions, including reinitiating translation on polycistronic mRNAs and acting as a receptor for protein kinases that control protein synthesis."
16920360
EIF3F affects RNF139
| 2
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
EIF3F affects PTN
1 1 |
EIF3F binds PTN. 2 / 2
1 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
EIF3F affects PSMD7
| 2
EIF3F binds PSMD7. 2 / 2
| 2
sparser
"MAFbx/atrogin-1 interacts with the Mov34 domain of eIF3f and promotes its ubiquitination resulting in proteasome-mediated degradation of eIF3f during muscle wasting ( xref ) ( xref )."
23769948
sparser
"LCD in MAFbx is thought to be critical for interaction with the MOV34 domain of eIF3f [12] , the EGLQALLR motif in MyoD [6] and the Forkhead domain of the transcription factors Foxo1 and 3A [18,19] ."
22249105
EIF3F affects PRKN
2 |
PRKN binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
35509820
biogrid
No evidence text available
35256949
EIF3F affects POLDIP3
| 2
POLDIP3 binds EIF3F. 2 / 2
| 2
sparser
"The binding and phosphorylation of eIF3f by CDK11 p46 may be one of the factors responsible for inhibition of global translation during apoptosis."
16829125
sparser
"Thr119 is located in the Mov34 domain of eIF3f which is important for both the translational inhibitory function of eIF3f [ xref ] and the protein-protein interaction of eIF3f with CDK11 p46 [ xref ]."
19245811
EIF3F affects PCa cells
| 2
EIF3F activates PCa cells. 2 / 2
| 2
eidos
"We confirmed that the loss of eIF3f reduced the proliferation of PCa cells , both in vitro and in vivo ."
32440143
eidos
"The proliferation rates of shRNA lentivirus-infected PCa cells indicated that eIF3f knockdown markedly decreased the proliferation of PCa cells ( Figure 1C ) ."
32440143
EIF3F affects NUP155
| 1 1
NUP42 binds NUP155 and EIF3F. 1 / 1
| 1
sparser
"Furthermore, the hCG1, Nup155 and eIF3f interactions were not perturbed by the PFQ insertion ( xref )."
24243016
NUP155 binds EIF3F. 1 / 1
| 1
reach
"Furthermore, the hCG1, Nup155 and eIF3f interactions were not perturbed by the PFQ insertion (XREF_SUPPLEMENTARY)."
24243016
EIF3F affects NIPSNAP2
2 |
biogrid
No evidence text available
35305106
biogrid
No evidence text available
35305106
EIF3F affects MTOR, and RPTOR
| 2
MTOR binds RPTOR and EIF3F. 2 / 2
| 2
sparser
"Mutation of the C-Terminal Lysines in eIF3f Increases Interaction with mTOR and Raptor."
20126553
sparser
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
EIF3F affects MIF
| 2
EIF3F activates MIF. 2 / 2
| 2
reach
"In this study, berberine inhibited the expression of MALT1 and EIF3F and subsequently suppressed the production of MIF and IL-4, suggesting that the regulation of MALT1 and EIF3F is involved in the at[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33539814
reach
"Interestingly, treatment with specific siRNAs for EIF3F and MALT1 markedly suppressed the DNP-induced production of MIF and IL-4 in mast cells."
33539814
EIF3F affects MAEL
2 |
MAEL binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
24189637
biogrid
No evidence text available
24189637
EIF3F affects IL4
| 2
EIF3F activates IL4. 2 / 2
| 2
reach
"In this study, berberine inhibited the expression of MALT1 and EIF3F and subsequently suppressed the production of MIF and IL-4, suggesting that the regulation of MALT1 and EIF3F is involved in the at[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33539814
reach
"Interestingly, treatment with specific siRNAs for EIF3F and MALT1 markedly suppressed the DNP-induced production of MIF and IL-4 in mast cells."
33539814
EIF3F affects HUWE1
2 |
HUWE1 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
25147182
biogrid
No evidence text available
37167062
EIF3F affects HAX1
1 1 |
EIF3F binds HAX1. 2 / 2
1 1 |
biogrid
No evidence text available
16189514
hprd
No evidence text available
16189514
EIF3F affects EZH2
2 |
EZH2 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
27634302
biogrid
No evidence text available
36517590
EIF3F affects ERK
| 2
EIF3F inhibits ERK. 2 / 2
| 2
reach
"EIF3f overexpression activates p53 and Bax and inhibits Akt and ERK signaling."
26988917
reach
"Furthermore, eIF3f can suppress Akt and ERK signaling, as well as stabilize p53 [60] In our data, eIF3f was also down-regulated, as is the case in melanoma and pancreatic cancer."
32498447
EIF3F affects ELAVL1, and Piwil1
| 2
Piwil1 binds EIF3F and ELAVL1. 2 / 2
| 2
sparser
"We next examined whether HuR associates with MIWI and eIF3f."
31835033
sparser
"Unlike 293T cells, mouse testes contain active piRNAs, and indeed, we detected significant association of endogenous HuR with both MIWI and eIF3f in mouse testes ( xref )."
31835033
EIF3F affects EIF5
2 |
EIF3F increases the amount of EIF5.
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L increases the amount of EIF5. 1 / 1
1 |
signor
"EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit"
17581632
EIF3F activates EIF5.
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L activates EIF5. 1 / 1
1 |
signor
"EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit"
17581632
EIF3F affects EIF4G3
2 |
EIF3F binds EIF4G3. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
24981860
EIF3F affects EIF4G2
1 1 |
EIF3F increases the amount of EIF4G2.
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L increases the amount of EIF4G2. 1 / 1
1 |
signor
"EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit"
17581632
EIF3F binds EIF4G2.
1 |
EIF3F binds EIF4G2. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3F affects EIF4E2
2 |
EIF3F binds EIF4E2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
EIF3F affects EIF3H, and RNF139
| 2
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
EIF3F affects E protein
| 2
EIF3F deubiquitinates E protein. 2 / 2
| 2
reach
"Meanwhile, EIF3S5 cannot promote E protein deubiquitination in LAMR1-knockdown HeLa cells (Figure 5d), highlighting that LAMR1 recruits EIF3S5 to mediate E protein deubiquitination."
34282707
reach
"We found that LAMR1 could interact with UPS13 (Figure 5a, lane 2) and EIF3S5 (Figure 5a, lane 9), but not with the control (Figure 5a, lane 1) or other proteins (Figure 5a, lanes 3–8, and 10), suggesting that EIF3S5 and UPS13 might be involved in the LAMR1-mediated deubiquitination of E protein."
34282707
EIF3F affects Death
| 2
EIF3F activates Death. 2 / 2
| 2
reach
"For instance, one hour treatment of MD 11 -wt eIF3f induced 30% death in Colo857 and HCT116 p53 -/- and 50% in B16 and HCT116 p53 +/+, while MD 11 -K510R killed as expected 50% of Colo857 cells and 100% of the others."
26052528
reach
"The same effect was reached in colorectal carcinoma cells lacking of p53 (HCT116 p53 -/-) in about 1 hour for MD 11 -K510R, 1.5 hours for MD 11 -NF and 3 hours for MD 11 -wt eIF3f, confirming that this cell line is more resistant than wild-type to the death stimulus and that p53 may play a role in eIF3f induced death (XREF_FIG)."
26052528
EIF3F affects DKC1
1 1 |
EIF3F binds DKC1. 2 / 2
1 1 |
biogrid
No evidence text available
16169070
hprd
No evidence text available
16169070
EIF3F affects COPS5
2 |
COPS5 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
31950832
EIF3F affects CDK11p46
| 1
CDK11p46 binds EIF3F. 1 / 2
| 1
reach
"When the number of Mss4 molecules in cells dropped down owing to ongoing stress, the CDK11p46 binds now and phosphorylates the released eIF3f resulting in inhibition of translation and initiation of apoptosis."
22495352
EIF3F affects CDK11 p46
| 2
EIF3F inhibits CDK11 p46. 2 / 2
| 2
reach
"To examine whether eIF3f SATA mutant attenuates apoptosis in CDK11 p46 overexpressing cells, we co-transfected CDK11 p46 with wild type or mutant eIF3f followed by apoptosis assay."
19245811
reach
"As predicted, eIF3f SATA mutant did attenuate apoptosis in CDK11 p46 overexpressing cells compared to wild type eIF3f (XREF_FIG)."
19245811
EIF3F affects ANLN
2 |
ANLN binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
36526897
biogrid
No evidence text available
31586073
EIF3F affects AGR2
2 |
AGR2 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
30575818
EIF3F affects 8
2 |
8 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
38043095
DKC1 affects EIF3F
1 1 |
EIF3F binds DKC1. 2 / 2
1 1 |
biogrid
No evidence text available
16169070
hprd
No evidence text available
16169070
COPS5 affects EIF3F
2 |
COPS5 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
31950832
ANLN affects EIF3F
2 |
ANLN binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
36526897
biogrid
No evidence text available
31586073
AKT affects EIF3F
| 2
AKT increases the amount of EIF3F. 2 / 2
| 2
reach
"Additional work is required to establish if Akt signaling activates eIF3f expression in prostate cancer."
32440143
reach
"This results indicated that Akt signaling might upregulate the expression level of eIF3f in PCa cells."
32440143
AGR2 affects EIF3F
2 |
AGR2 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
30575818
8 affects EIF3F
2 |
8 binds EIF3F. 2 / 2
2 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
38043095
Valproic acid affects EIF3F
1 |
Valproic acid increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
26272509
Triphenyl phosphate increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
31368501
Translocon-associated activates EIF3F. 1 / 1
| 1
reach
"Inactive rhomboid protein (iRhom2) recruits the translocon-associated protein TRAPβ to promote STING trafficking and the deubiquitinating enzyme EIF3S5 to stabilize STING, leading to STING activation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37201875
Tetrachloromethane increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
31919559
Tat affects EIF3F
1 |
Tat binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
19454010
Sodium chloride affects EIF3F
1 |
Sodium chloride increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
38598786
Saxitoxin affects EIF3F
1 |
Saxitoxin increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
39571800
Rotenone affects EIF3F
1 |
Rotenone increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
39786591
Rhomboid affects EIF3F
| 1
Rhomboid binds EIF3F. 1 / 1
| 1
reach
"Mechanistically, inactive rhomboid protein two recruits translocon-associated protein and deubiquitination enzyme EIF3S5 to facilitate the trafficking and stability of STING, respectively98."
35127372
Raptor-mTOR affects EIF3F
| 1
Raptor-mTOR binds EIF3F. 1 / 1
| 1
reach
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
Progesterone affects EIF3F
1 |
Progesterone increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
20631399
Potassium chromate increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
22714537
Phosphate(3-) affects EIF3F
| 1
Phosphate(3-) leads to the phosphorylation of EIF3F. 1 / 1
| 1
reach
"The mutation of the phosphate transfer site in CDK11p46 abrogates the phosphorylation of eIF3f protein."
23354061
Perfluorooctanesulfonamide increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
31706782
Perfluorooctane-1-sulfonic acid increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
36331819
Okadaic acid affects EIF3F
1 |
Okadaic acid decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
38832940
Nickel acetate affects EIF3F
1 |
Nickel acetate increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
23828170
MutS affects EIF3F
| 1
EIF3F binds mutS. 1 / 1
| 1
reach
"EIF3f also binds to the stress-stimulated protein MSS4, resulting in a reduced ability to inhibit protein synthesis [122] , and binds and stabilizes the MutS homolog hMSH4, a protein involved in doubl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25450521
MiceTo affects EIF3F
| 1
MiceTo activates EIF3F. 1 / 1
| 1
reach
"Generation of eIF3f +/- miceTo produce eIF3f gene KO mice B6-eIF3ftm1 (KOMP) Vlcg, we used targeted embryonic stem cells generated by the trans-NIH Knock-Out Mouse Project (KOMP; www.komp.org, RRID : SCR_005571)."
31026345
Methyl methanesulfonate increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
26011545
Mercury(0) affects EIF3F
1 |
Mercury(0) decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
16823088
Ivermectin affects EIF3F
1 |
Ivermectin decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
32959892
Hsa-miR-6807-5p affects EIF3F
1 |
Hsa-miR-6807-5p decreases the amount of EIF3F. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-550b-2-5p affects EIF3F
1 |
Hsa-miR-550b-2-5p decreases the amount of EIF3F. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-550a-5p affects EIF3F
1 |
Hsa-miR-550a-5p decreases the amount of EIF3F. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-550a-3-5p affects EIF3F
1 |
Hsa-miR-550a-3-5p decreases the amount of EIF3F. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-3116 affects EIF3F
1 |
Hsa-miR-3116 decreases the amount of EIF3F. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-1254 affects EIF3F
1 |
Hsa-miR-1254 decreases the amount of EIF3F. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Heterogenous nuclear ribonucleoprotein K affects EIF3F
| 1
EIF3F binds heterogenous nuclear ribonucleoprotein K. 1 / 1
| 1
reach
"The discovery that eIF3f can interact with the heterogenous nuclear ribonucleoprotein K (hnRNP K) during apoptosis in melanoma and HPDE cells corroborates this model [XREF_BIBR]."
23354061
Heterogeneous nuclear ribonucleoprotein affects RNA-binding
| 1
RNA-binding binds EIF3F and heterogeneous nuclear ribonucleoprotein. 1 / 1
| 1
sparser
"In this model, rRNA degradation is carried out by direct interaction between eIF3f and heterogeneous nuclear ribonucleoprotein (hnRNP) K, a RNA-binding protein required for maintaining rRNA stability [ xref ]."
| PMC
HCG1 affects EIF3F
| 1
HCG1 binds EIF3F. 1 / 1
| 1
reach
"Furthermore, the hCG1, Nup155 and eIF3f interactions were not perturbed by the PFQ insertion (XREF_SUPPLEMENTARY)."
24243016
Gag-pol affects EIF3F
1 |
Gag-pol binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
22190034
Furfural affects EIF3F
1 |
Furfural increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
38598786
Folic acid affects EIF3F
1 |
Folic acid demethylates EIF3F. 1 / 1
1 |
ctd
No evidence text available
20938992
Fipronil affects EIF3F
1 |
Fipronil increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
34044035
Estrogen affects EIF3F
| 1
Estrogen bound to ESR1 decreases the amount of EIF3F. 1 / 1
| 1
reach
"Specifically, estrogen bound ERalpha represses transcription of the EIF3F gene, while promoting eIF3f mRNA translation."
30573685
EIF3 core affects EIF3F
| 1
EIF3F binds eIF3 core. 1 / 1
| 1
reach
"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
19245811
Deoxynivalenol affects EIF3F
1 |
Deoxynivalenol increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
39638853
Copper(II) sulfate decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
19549813
Clothianidin affects EIF3F
1 |
Clothianidin decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
31626844
Chlorpyrifos affects EIF3F
1 |
Chlorpyrifos increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
37019170
Chloropicrin affects EIF3F
1 |
Chloropicrin decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
28476498
Catenin affects EIF3F
| 1
Catenin binds EIF3F. 1 / 1
| 1
reach
"These data indicate that EIF3F is a transcriptional target of the Wnt signaling pathway via β‐catenin/TCF4 binding to the EIF3F promoter.2.7 Combination Treatment of NCT503 and LGK-974 Mitigated Tumor Growth in eIF3f High Human PDX CRC Models with Better Efficacy through Hindering Wnt-eIF3f-PHGDH Signaling Axis."
37544925
Bis(2-ethylhexyl) phthalate increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
33754040
Beta-naphthoflavone increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
39638853
Antirheumatic drug increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
24449571
Alpha-chain affects EIF3F
| 1
EIF3F binds alpha-chain. 1 / 1
| 1
reach
"Interestingly, eif3f interacts with alpha-chain but PACAP binds with beta-chain of CLU."
26988917
All-trans-retinoic acid decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
33167477
Aflatoxin B1 affects EIF3F
1 |
Aflatoxin B1 demethylates EIF3F. 1 / 1
1 |
ctd
No evidence text available
27153756
ZNF598 affects EIF3F
1 |
ZNF598 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
28685749
YOD1 affects EIF3F
1 |
YOD1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37667382
YAP1 affects EIF3F
1 |
EIF3F binds YAP1. 1 / 1
1 |
biogrid
No evidence text available
29891922
XRCC3 affects EIF3F
1 |
XRCC3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26496610
WDR5 affects EIF3F
1 |
WDR5 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33022573
VCP affects EIF3F
1 |
EIF3F binds VCP. 1 / 1
1 |
biogrid
No evidence text available
31527668
USP14 affects EIF3F
1 |
USP14 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
30425250
UFL1 affects EIF3F
1 |
UFL1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32807901
UBQLN2 affects EIF3F
1 |
UBQLN2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
30442662
UBE2H affects EIF3F
1 |
UBE2H binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
38113892
Thr-119 affects EIF3F
| 1
Caspase binds EIF3F and Thr-119. 1 / 1
| 1
reach
"Moreover, caspase processed isoform of the cell division kinase 11 (Cdk11 p46) binds and phosphorylates eIF3f at Ser 46 and Thr 119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation."
23769948
TUBB4B affects EIF3F
1 |
EIF3F binds TUBB4B. 1 / 1
1 |
biogrid
No evidence text available
31527668
TUBA1A affects EIF3F
1 |
EIF3F binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
31527668
TRIM63 affects EIF3F
| 1
TRIM63 ubiquitinates EIF3F. 1 / 1
| 1
reach
"MuRF-1 predominantly ubiquitinates myosin heavy chain, myosin light chains 1 and 2, troponin I, and myosin binding protein C [9], whereas atrogin-1 targets eukaryotic translation initiation factor 3 subunit f (eIF3-f), myosin heavy chain, myogenic differentiation antigen (MyoD), and other sarcomeric proteins such as desmin and the intermediate filament protein vimentin [7,10]."
39125931
TMBIM1 affects EIF3F
1 |
EIF3F binds TMBIM1. 1 / 1
1 |
biogrid
No evidence text available
40437099
SUPT5H affects EIF3F
1 |
EIF3F binds SUPT5H. 1 / 1
1 |
biogrid
No evidence text available
31527668
SLFN11 affects EIF3F
1 |
SLFN11 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33863777
SHBG affects EIF3F
1 |
EIF3F binds SHBG. 1 / 1
1 |
hprd
No evidence text available
15862967
SFPQ affects EIF3F
1 |
EIF3F binds SFPQ. 1 / 1
1 |
biogrid
No evidence text available
31527668
SF3B3 affects EIF3F
| 1
SF3B3 binds EIF3F. 1 / 1
| 1
sparser
"Five of these proteins have known or putative ATP binding domains (UBA1, HSP90AA1, HSPA2, RUVBL2 and ATP5B/ATP5A1), which is in accord with quercetin's known ability to inhibit ATPases and kinases. xref The remaining proteins, SF3B3 and EIF3F are not associated with nucleotide binding domains, and may bind to quercetin through some other site."
21798748
SERBP1 affects EIF3F
1 |
SERBP1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37223481
Rpl35 affects EIF3F
1 |
Rpl35 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26496610
RTRAF affects EIF3F
1 |
EIF3F binds RTRAF. 1 / 1
1 |
biogrid
No evidence text available
31527668
RPS17 affects EIF3F
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L binds RPS17 bound to RPSA, RPS2, RPS4Y1, RPS3, RPS12, RPS19, RPS27, RPS9, RPS5, RPS10, RPS20, RPS3A, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS23, RPS18, RPS29, RPS13, RPS11, RPS4X, RPS6, RPS15, RPS24, RPS25, RPS26, RPS28, FAU, RPS27A, RPS21, RPS27L, and RPS4Y2. 1 / 1
1 |
signor
"EIF3 binds 40S and inhibits the association of 60S. Structural analysis suggests that eIF3 performs this scaffolding function by binding to the 40S subunit on its solvent-exposed surface rather than on its interface with the 60S subunit, where the decoding sites exist. This location of eIF3 seems ideally suited for its other proposed regulatory functions, including reinitiating translation on polycistronic mRNAs and acting as a receptor for protein kinases that control protein synthesis."
16920360
RPS11 affects EIF3F
1 |
RPS11 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35271311
RPA3 affects EIF3F
1 |
RPA3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37827155
RPA2 affects EIF3F
1 |
RPA2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37827155
RNF2 affects EIF3F
1 |
RNF2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
24457600
RNF144A affects EIF3F
1 |
RNF144A binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29212245
RNA-binding affects heterogeneous nuclear ribonucleoprotein
| 1
RNA-binding binds EIF3F and heterogeneous nuclear ribonucleoprotein. 1 / 1
| 1
sparser
"In this model, rRNA degradation is carried out by direct interaction between eIF3f and heterogeneous nuclear ribonucleoprotein (hnRNP) K, a RNA-binding protein required for maintaining rRNA stability [ xref ]."
| PMC
RECQL4 affects EIF3F
1 |
RECQL4 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29229926
RBM39 affects EIF3F
1 |
RBM39 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
28302793
RBM10 affects EIF3F
1 |
EIF3F binds RBM10. 1 / 1
1 |
biogrid
No evidence text available
31527668
RAD21 affects EIF3F
1 |
RAD21 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
22145905
RACK1 affects EIF3F
1 |
RACK1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35271311
Pool 1 affects EIF3F
| 1
Pool 1 activates EIF3F. 1 / 1
| 1
reach
"The shRNA library actually contained two pools (each containing four shRNA encoding plasmids) targeting eIF3f : Pool 1, whose effects are shown in XREF_FIG, and Pool 2, in the presence of which no DeltaE positive signal could be detected by immunofluorescence (unpublished data)."
21124883
Particulate Matter increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
35964746
PRRC2A affects EIF3F
1 |
EIF3F binds PRRC2A. 1 / 1
1 |
biogrid
No evidence text available
19615732
PRMT1 affects EIF3F
1 |
PRMT1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
34728620
PRC1 affects EIF3F
1 |
PRC1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31586073
POGZ affects EIF3F
1 |
POGZ binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
PKN1 affects EIF3F
1 |
PKN1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
PKC affects EIF3F
| 1
PKC phosphorylates EIF3F. 1 / 1
| 1
sparser
"These results show that the agonist-induced phosphorylation of the 47KDa protein by protein kinase C does not impart the ability to activate phospholipase A2 in human platelets, and questions the suggestion that the 47KDa protein is lipocortin."
2948506
PI3K_p110 affects EIF3F
| 1
EIF3F binds PI3K_p110. 1 / 1
| 1
reach
"In a second and more detailed study, the authors showed a weak interaction between eIF3 p47 and CDK11 p110 in proliferating cells, and a strong interaction with CDK11 p46 during apoptosis."
15935619
PI3K affects EIF3F
| 1
PI3K phosphorylates EIF3F. 1 / 1
| 1
reach
"Phosphorylated eIF3f was separated from un phosphorylated eIF3f by different pI."
19245811
PCBP1 affects EIF3F
1 |
PCBP1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35102251
PBX4 affects EIF3F
1 |
PBX4 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
PA affects EIF3F
1 |
EIF3F binds PA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
OGT affects EIF3F
1 |
OGT binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32994395
Nitrates affects EIF3F
1 |
Nitrates increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
35964746
NUP42 affects NUP155
| 1
NUP42 binds NUP155 and EIF3F. 1 / 1
| 1
sparser
"Furthermore, the hCG1, Nup155 and eIF3f interactions were not perturbed by the PFQ insertion ( xref )."
24243016
NTRK1 affects EIF3F
1 |
NTRK1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
25921289
NPM1 affects EIF3F
1 |
NPM1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35271311
NONO affects EIF3F
1 |
EIF3F binds NONO. 1 / 1
1 |
biogrid
No evidence text available
31527668
NLRP3 affects EIF3F
1 |
NLRP3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33243234
NFX1 affects EIF3F
1 |
NFX1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31059266
NCT503 affects EIF3F
| 1
NCT503 binds EIF3F. 1 / 1
| 1
reach
"These data indicate that EIF3F is a transcriptional target of the Wnt signaling pathway via β‐catenin/TCF4 binding to the EIF3F promoter.2.7 Combination Treatment of NCT503 and LGK-974 Mitigated Tumor Growth in eIF3f High Human PDX CRC Models with Better Efficacy through Hindering Wnt-eIF3f-PHGDH Signaling Axis."
37544925
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits EIF3F. 1 / 1
| 1
reach
"Moreover, eIF3f KD‐mediated PHGDH downregulation could be rescued by the proteasome inhibitor MG132 (Figure 2E)."
37544925
MYDGF affects EIF3F
1 |
MYDGF binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
MTSS1 affects EIF3F
1 |
MTSS1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35122005
MSMO1 affects EIF3F
1 |
EIF3F binds MSMO1. 1 / 1
1 |
biogrid
No evidence text available
22939629
MPC2 affects EIF3F
1 |
EIF3F binds MPC2. 1 / 1
1 |
biogrid
No evidence text available
33961781
MKRN2 affects EIF3F
1 |
MKRN2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
MIR661 affects EIF3F
1 |
MIR661 decreases the amount of EIF3F. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
MEPCE affects EIF3F
1 |
MEPCE binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29845934
MECP2 affects EIF3F
1 |
MECP2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
38697112
MAPT affects EIF3F
1 |
MAPT binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
36634849
MAP1B affects EIF3F
1 |
EIF3F binds MAP1B. 1 / 1
1 |
biogrid
No evidence text available
31527668
MAK affects EIF3F
1 |
MAK binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32707033
MAFbx Atrogin-1 affects EIF3F
| 1
MAFbx Atrogin-1 inhibits EIF3F. 1 / 1
| 1
eidos
"MAFbx / Atrogin-1 increased eIF3-f degradation in myotubes undergoing atrophy in vitro , and overexpression of eIF3-f caused hypertrophy both in vitro and in vivo ."
32858949
M affects EIF3F
1 |
EIF3F binds M. 1 / 1
1 |
virhostnet
No evidence text available
25464832
LGK974 affects EIF3F
| 1
LGK974 decreases the amount of EIF3F. 1 / 1
| 1
reach
"40 Our study demonstrated that LGK974 potently reduced the expression of eIF3f by inhibiting Wnt signaling."
37544925
Ksr1 affects EIF3F
1 |
Ksr1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26549023
KRT9 affects EIF3F
1 |
EIF3F binds KRT9. 1 / 1
1 |
biogrid
No evidence text available
31527668
KRT8 affects EIF3F
1 |
EIF3F binds KRT8. 1 / 1
1 |
biogrid
No evidence text available
31527668
KRT6B affects EIF3F
1 |
EIF3F binds KRT6B. 1 / 1
1 |
biogrid
No evidence text available
31527668
KRT2 affects EIF3F
1 |
EIF3F binds KRT2. 1 / 1
1 |
biogrid
No evidence text available
31527668
KRT14 affects EIF3F
1 |
EIF3F binds KRT14. 1 / 1
1 |
biogrid
No evidence text available
31527668
KRT10 affects EIF3F
1 |
EIF3F binds KRT10. 1 / 1
1 |
biogrid
No evidence text available
31527668
KRT1 affects EIF3F
1 |
EIF3F binds KRT1. 1 / 1
1 |
biogrid
No evidence text available
31527668
KLHL20 affects EIF3F
1 |
KLHL20 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26687681
KLF16 affects EIF3F
1 |
KLF16 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35140242
KIF11 affects EIF3F
1 |
EIF3F binds KIF11. 1 / 1
1 |
biogrid
No evidence text available
31527668
KAT6A affects EIF3F
1 |
KAT6A binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
36537216
K48 affects EIF3F
| 1
EIF3F binds ACSL4 and K48. 1 / 1
| 1
reach
"EIF3f directly interacted with and stabilised long chain acyl CoA synthetase 4 (ACSL4) through K48-linked deubiquitination, promoting fatty acid biosynthesis (FAB) and tumour malignancy."
40154622
Itsn2 affects EIF3F
1 |
Itsn2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26496610
IMMT affects EIF3F
1 |
EIF3F binds IMMT. 1 / 1
1 |
biogrid
No evidence text available
19615732
IGKV2D-29 affects EIF3F
1 |
EIF3F binds IGKV2D-29. 1 / 1
1 |
biogrid
No evidence text available
31527668
ICG 001 affects EIF3F
1 |
ICG 001 decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
26191083
HTR2A affects EIF3F
1 |
HTR2A binds EIF3F. 1 / 1
1 |
hprd
No evidence text available
16537434
HSPA8 affects EIF3F
1 |
EIF3F binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
31527668
HNRNPU affects EIF3F
1 |
EIF3F binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
31527668
HDAC6 affects EIF3F
1 |
HDAC6 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35676659
HDAC5 affects EIF3F
1 |
HDAC5 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
21081666
HA affects EIF3F
1 |
EIF3F binds HA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
Glyphosate affects EIF3F
1 |
Glyphosate decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
37208198
Gentamicins affects EIF3F
1 |
Gentamicins increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
22061828
GTF2E2 affects EIF3F
1 |
EIF3F binds GTF2E2. 1 / 1
1 |
biogrid
No evidence text available
31527668
GSTA5 affects EIF3F
1 |
GSTA5 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33961781
GSK-J4 affects EIF3F
1 |
GSK-J4 increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
29301935
GPX1 affects EIF3F
| 1
EIF3F binds GPX1. 1 / 1
| 1
sparser
"For example, eIF3e, f, and g have similar molecular weights, but no crosslinking signal could be observed between eIF3f and GPx1 mRNA because Western blot and radioactivity signals do not overlay ( xref d), showing that eIF3f does not interact with GPx1 mRNA."
36139107
G3BP2 affects EIF3F
1 |
G3BP2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35271311
FOXO1 affects EIF3F
1 |
FOXO1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
36964488
FMN1 affects EIF3F
| 1
FMN1 inhibits EIF3F. 1 / 1
| 1
reach
"Within the LD block of EIF3F, five of seven common SNPs (rs79714374, rs12421289, rs12278319, rs7941782, rs4758267, rs12420464, rs56392532) were identified to be tagging SNPs for six different haplotypes with frequencies between 3.5 and 53.4%."
33736665
FLNA affects EIF3F
1 |
EIF3F binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
31527668
Eif3i affects EIF3F
1 |
Eif3i binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26496610
ESR2 affects EIF3F
1 |
ESR2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29509190
ERCC6 affects EIF3F
1 |
ERCC6 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31722399
EP300 affects EIF3F
1 |
EP300 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33742100
EML2 affects EIF3F
1 |
EML2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF4G2 affects EIF3F
1 |
EIF3F binds EIF4G2. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF4ENIF1 affects EIF3F
1 |
EIF3F binds EIF4ENIF1. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF4EBP2 affects EIF3F
1 |
EIF4EBP2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF3K affects EIF3E
| 1
EIF3E binds EIF3F and EIF3K. 1 / 1
| 1
sparser
"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
26399914
EIF3J affects EIF3F
1 |
EIF3F binds EIF3J. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3F affects tumor-free survival
| 1
EIF3F inhibits tumor-free survival. 1 / 1
| 1
eidos
"In addition , the inhibition of eIF3f expression led to delayed tumor onset and improved tumor-free survival rates in nude mice ( Figure 3C ) ."
32440143
EIF3F affects translational phase cells synchronized nocodazole treatment
| 1
EIF3F inhibits translational phase cells synchronized nocodazole treatment. 1 / 1
| 1
eidos
"Even though translational repression in M phase cells , synchronized by nocodazole treatment , was partially nullified by the expression of eIF3F ( A3A4 ) , nocodazole induces stress-related translational inhibition that obscures the magnitude of translation repression in M phase [ 60 ] ."
32030451
EIF3F inhibits translational initiation. 1 / 1
| 1
reach
"In addition, TbIF3f knockdown resulted in polysome reduction and translation initiation inhibition (Fig. 3), while human eIF3f depletion promoted the translation initiation (Wen et al. 2012)."
27932584
EIF3F affects tat
1 |
Tat binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
19454010
EIF3F affects specific robust recruitment endogenous eIF4G raptor rpS6 m7-GTP cap complex
| 1
EIF3F activates specific robust recruitment endogenous eIF4G raptor rpS6 m7-GTP cap complex. 1 / 1
| 1
eidos
"It is important to note that eIF3f induces a specific and robust recruitment of endogenous eIF4G , raptor and rpS6 to the m7-GTP cap complex , suggesting that this protein is not only an activator of the cap-dependent translation but also a major actor of the proper assembly of the translation initiation complex in myotubes ( Csibi et al ., 2010 ) ."
23769948
EIF3F affects snail2
| 1
EIF3F bound to STAT3 increases the amount of snail2. 1 / 1
| 1
reach
"XREF_BIBR Esteves et al XREF_BIBR reported that eIF3f interacted with STAT3 and increased snail2 expression, thereby promoting lung cancer metastasis."
32440143
EIF3F affects rhomboid
| 1
Rhomboid binds EIF3F. 1 / 1
| 1
reach
"Mechanistically, inactive rhomboid protein two recruits translocon-associated protein and deubiquitination enzyme EIF3S5 to facilitate the trafficking and stability of STING, respectively98."
35127372
EIF3F affects raptor-mTOR
| 1
Raptor-mTOR binds EIF3F. 1 / 1
| 1
reach
"The raptor-mTOR binding to eIF3f physically does displace S6K1 from eIF3f but S6K1 phosphorylation by mTORC1 alters the ability of eIF3f and S6K1 to interact."
20126553
EIF3F affects poly-GP protein
| 1
EIF3F increases the amount of poly-GP protein. 1 / 1
| 1
reach
"Knockdown of eIF3F caused a 43% reduction of poly-GP protein level [138]."
37626421
EIF3F affects mutS
| 1
EIF3F binds mutS. 1 / 1
| 1
reach
"EIF3f also binds to the stress-stimulated protein MSS4, resulting in a reduced ability to inhibit protein synthesis [122] , and binds and stabilizes the MutS homolog hMSH4, a protein involved in doubl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25450521
EIF3F affects muscle atrophy
| 1
EIF3F activates muscle atrophy. 1 / 1
| 1
reach
"Atrogin-1 promotes the degradation of nuclear transcription factors related to skeletal muscle hypertrophy and protein synthesis, such as MyoD and eIF3f, which leads to muscle atrophy."
31765742
EIF3F affects modification
| 1
EIF3F activates modification. 1 / 1
| 1
sparser
"These results suggest that eIF3f activates the structural modification of sCLU into its mature form, which results in decreased sCLU expression and secretion."
26988917
EIF3F affects migratory lung cancer cells
| 1
EIF3F activates migratory lung cancer cells. 1 / 1
| 1
eidos
"The increased level of Snail , Claudin-1 , and ZO-1 also suggested that EIF3F improved the migratory phenotype of lung cancer cells , in line with the functional evaluation of cell migration shown in Fig. 2 ."
31527668
EIF3F affects luciferase reporter gene
| 1
EIF3F activates luciferase reporter gene. 1 / 1
| 1
reach
"To confirm this data, G0 and serum stimulated cells were transiently transfected with a plasmid containing a luciferase reporter gene driven by the first kilobase of the human active eIF3f promoter (see section below)."
20462454
EIF3F affects host
| 1
EIF3F inhibits host. 1 / 1
| 1
eidos
"Furthermore , eIF3f can also interact with the S protein of SARS-CoV and infectious bronchitis virus ( IBV ) to inhibit expression of host genes ( Xiao et al ., 2008 ) ."
29173589
EIF3F affects heterogenous nuclear ribonucleoprotein K
| 1
EIF3F binds heterogenous nuclear ribonucleoprotein K. 1 / 1
| 1
reach
"The discovery that eIF3f can interact with the heterogenous nuclear ribonucleoprotein K (hnRNP K) during apoptosis in melanoma and HPDE cells corroborates this model [XREF_BIBR]."
23354061
EIF3F affects hCG1
| 1
HCG1 binds EIF3F. 1 / 1
| 1
reach
"Furthermore, the hCG1, Nup155 and eIF3f interactions were not perturbed by the PFQ insertion (XREF_SUPPLEMENTARY)."
24243016
EIF3F affects gag-pol
1 |
Gag-pol binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
22190034
EIF3F affects formation
| 1
EIF3F inhibits formation. 1 / 1
| 1
sparser
"Furthermore, eIF3f-silenced cells have up to 2.5-fold increase in P-body-bearing cells, suggesting that eIF3f may inhibit P body formation ( xref )."
22457825
EIF3F activates fatty acid biosynthetic process. 1 / 1
| 1
reach
"EIF3f promotes tumour malignancy by remodelling fatty acid biosynthesis in hepatocellular carcinoma."
40154622
EIF3F affects env
| 1
EIF3F leads to the deubiquitination of env. 1 / 1
| 1
reach
"Knockdown of EIF3S5 reduced Env deubiquitination and increased the levels of NS5, Env, and viral RNA in infected HeLa cells (Hu et al., 2021) ."
35308381
EIF3F affects efficient protein synthesis
| 1
EIF3F activates efficient protein synthesis. 1 / 1
| 1
eidos
"Active mTORC1 then resides in areas close to blood vessels , amino acid transporters , and translation initiation factors ( eIF3F ) , which allows a more efficient stimulation of protein synthesis that is elevated subsequently ( B ) ."
30334852
EIF3F affects eIF3 core
| 1
EIF3F binds eIF3 core. 1 / 1
| 1
reach
"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
19245811
EIF3F affects catenin
| 1
Catenin binds EIF3F. 1 / 1
| 1
reach
"These data indicate that EIF3F is a transcriptional target of the Wnt signaling pathway via β‐catenin/TCF4 binding to the EIF3F promoter.2.7 Combination Treatment of NCT503 and LGK-974 Mitigated Tumor Growth in eIF3f High Human PDX CRC Models with Better Efficacy through Hindering Wnt-eIF3f-PHGDH Signaling Axis."
37544925
EIF3F affects cap-dependent translation
| 1
EIF3F inhibits cap-dependent translation. 1 / 1
| 1
eidos
"a eIF3F ( A3A4 ) nullifies the cap-dependent translation repression by CDK11 / p58 , but eIF3F ( A1A2 ) nullifies the cap-dependent translation repression by CDK11 / p46 ."
32030451
EIF3F affects cap-dependent cap-independent translation
| 1
EIF3F inhibits cap-dependent cap-independent translation. 1 / 1
| 1
eidos
"Mechanistically , the authors found that eIF3f inhibits both cap-dependent and cap-independent translation and that eIF3f promotes rRNA degradation through direct interaction with heterogeneous nuclear ribonucleoprotein K ( Wen et al ., 2012 ) ."
23769948
EIF3F affects anti-atrophic myotubes miRNA mimics
| 1
EIF3F activates anti-atrophic myotubes miRNA mimics. 1 / 1
| 1
eidos
"These results indicated that not only the decrease in Atrogin-1 , a proteolytic enzyme , but also the increase in eIF3f , a protein translation initiation component , contributes to the anti-atrophic effect on myotubes by miRNA mimics ."
32495509
EIF3F affects alpha-chain
| 1
EIF3F binds alpha-chain. 1 / 1
| 1
reach
"Interestingly, eif3f interacts with alpha-chain but PACAP binds with beta-chain of CLU."
26988917
EIF3F affects adult skeletal muscle
| 1
EIF3F activates adult skeletal muscle. 1 / 1
| 1
eidos
"Furthermore , in mouse models , eIF3f depletion impedes embryonic development , reduces adult skeletal muscle mass and amplifies muscle loss during disuse [ 18 ] ."
31728542
EIF3F affects activity
| 1
EIF3F inhibits activity. 1 / 1
| 1
sparser
"To assess how eIF3f inhibits CLU activity, we generated several deletion constructs and analyzed the specific sites responsible for the binding between eIF3f and CLU."
26988917
EIF3F affects activation
| 1
EIF3F inhibits activation. 1 / 1
| 1
sparser
"That is, if eIF3f stimulates or inhibits Alpha 1B-ADR activation."
26497985
EIF3F affects ZNF598
1 |
ZNF598 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
28685749
EIF3F affects YOD1
1 |
YOD1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37667382
EIF3F affects YAP1
1 |
EIF3F binds YAP1. 1 / 1
1 |
biogrid
No evidence text available
29891922
EIF3F affects XRCC3
1 |
XRCC3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3F affects Wnt
| 1
EIF3F deubiquitinates Wnt. 1 / 1
| 1
reach
"Moreover, eIF3f can deubiquitinate and stabilize MYC, a Wnt target and a transcription activator of PHGDH, to regulate PHGDH transcriptionally."
37544925
EIF3F affects WDR5
1 |
WDR5 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33022573
EIF3F affects VCP
1 |
EIF3F binds VCP. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects USP14
1 |
USP14 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
30425250
EIF3F affects UFL1
1 |
UFL1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32807901
EIF3F affects UBQLN2
1 |
UBQLN2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
30442662
EIF3F affects UBE2H
1 |
UBE2H binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
38113892
EIF3F affects Thr-119
| 1
Caspase binds EIF3F and Thr-119. 1 / 1
| 1
reach
"Moreover, caspase processed isoform of the cell division kinase 11 (Cdk11 p46) binds and phosphorylates eIF3f at Ser 46 and Thr 119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation."
23769948
EIF3F affects TUBB4B
1 |
EIF3F binds TUBB4B. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects TUBA1A
1 |
EIF3F binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects TMBIM1
1 |
EIF3F binds TMBIM1. 1 / 1
1 |
biogrid
No evidence text available
40437099
EIF3F affects SUPT5H
1 |
EIF3F binds SUPT5H. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects SLFN11
1 |
SLFN11 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33863777
EIF3F affects SHBG
1 |
EIF3F binds SHBG. 1 / 1
1 |
hprd
No evidence text available
15862967
EIF3F affects SFPQ
1 |
EIF3F binds SFPQ. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects SF3B3
| 1
SF3B3 binds EIF3F. 1 / 1
| 1
sparser
"Five of these proteins have known or putative ATP binding domains (UBA1, HSP90AA1, HSPA2, RUVBL2 and ATP5B/ATP5A1), which is in accord with quercetin's known ability to inhibit ATPases and kinases. xref The remaining proteins, SF3B3 and EIF3F are not associated with nucleotide binding domains, and may bind to quercetin through some other site."
21798748
EIF3F affects SERBP1
1 |
SERBP1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37223481
EIF3F affects Rpl35
1 |
Rpl35 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3F affects RTRAF
1 |
EIF3F binds RTRAF. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects RPS11
1 |
RPS11 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3F affects RPA3
1 |
RPA3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37827155
EIF3F affects RPA2
1 |
RPA2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37827155
EIF3F affects RNF2
1 |
RNF2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
24457600
EIF3F affects RNF144A
1 |
RNF144A binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29212245
EIF3F affects RNA-binding, and heterogeneous nuclear ribonucleoprotein
| 1
RNA-binding binds EIF3F and heterogeneous nuclear ribonucleoprotein. 1 / 1
| 1
sparser
"In this model, rRNA degradation is carried out by direct interaction between eIF3f and heterogeneous nuclear ribonucleoprotein (hnRNP) K, a RNA-binding protein required for maintaining rRNA stability [ xref ]."
| PMC
EIF3F affects RECQL4
1 |
RECQL4 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29229926
EIF3F affects RBX1
1 |
RBX1 bound to SKP1 and CUL1 binds EIF3F. 1 / 1
1 |
signor
"Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome."
18354498
EIF3F affects RBM39
1 |
RBM39 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
28302793
EIF3F affects RBM10
1 |
EIF3F binds RBM10. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects RAD21
1 |
RAD21 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
22145905
EIF3F affects RACK1
1 |
RACK1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3F activates Prostatic Neoplasms. 1 / 1
| 1
eidos
"In silico analyses suggested that eIF3f may promote the progression of PCa ."
32440143
EIF3F affects Phosphorylation Akt
| 1
EIF3F activates Phosphorylation Akt. 1 / 1
| 1
eidos
"EIF3f Downregulation Inhibited Phosphorylation of Akt in PCa Cells To investigate the mechanism underlying the inhibitory effects of eIF3f silencing on PCa cell growth , we performed RNA-Seq analysis of 22Rv1 cells , with or without eIF3f knockdown ."
32440143
EIF3F affects Pathway
| 1
EIF3F inhibits Pathway. 1 / 1
| 1
sparser
"Knockdown of eIF3f Inhibited Serine Synthesis Pathway in CRC Cells and Suppressed Tumor Growth In Vivo."
37544925
EIF3F affects PSPH
| 1
EIF3F decreases the amount of PSPH. 1 / 1
| 1
reach
"Immunohistochemistry and immunoblotting showed that tumors with eIF3f KD exhibited a marked reduction in proliferation marker Ki‐67 and reduced the PHGDH, PSPH, PSAT1, and MYC expression (Figure 5E)."
37544925
EIF3F affects PRRC2A
1 |
EIF3F binds PRRC2A. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3F affects PRMT1
1 |
PRMT1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
34728620
EIF3F affects PRC1
1 |
PRC1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31586073
EIF3F affects POGZ
1 |
POGZ binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3F affects PKN1
1 |
PKN1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3F affects PI3K_p110
| 1
EIF3F binds PI3K_p110. 1 / 1
| 1
reach
"In a second and more detailed study, the authors showed a weak interaction between eIF3 p47 and CDK11 p110 in proliferating cells, and a strong interaction with CDK11 p46 during apoptosis."
15935619
EIF3F affects PI3K/Akt/mTOR
| 1
EIF3F activates PI3K/Akt/mTOR. 1 / 1
| 1
reach
"The RNA-seq data using 22Rv1 cells and published datasets both revealed that the disruption of eIF3f suppressed PI3K/Akt/mTOR signaling."
32440143
EIF3F affects PI3K Akt mTOR
| 1
EIF3F activates PI3K Akt mTOR. 1 / 1
| 1
eidos
"The RNA-seq data using 22Rv1 cells and published datasets both revealed that the disruption of eIF3f suppressed PI3K / Akt / mTOR signaling ."
32440143
EIF3F affects PCa cell
| 1
EIF3F activates PCa cell. 1 / 1
| 1
eidos
"These results indicated that eIF3f knockdown caused inhibition of PCa cell proliferation at least partially through the suppression of Akt phosphorylation.Ectopic expression of Myr-Akt alleviated PCa cell proliferation of eIF3f knockdown cells ."
32440143
EIF3F affects PCBP1
1 |
PCBP1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35102251
EIF3F affects PBX4
1 |
PBX4 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3F affects PA
1 |
EIF3F binds PA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
EIF3F affects OGT
1 |
OGT binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32994395
EIF3F activates Neoplasm Invasiveness. 1 / 1
| 1
reach
"Overexpression of EIF3F in these cells has been shown to enhance cell migration and invasion by interacting with STAT3 and modulating a series of genes associated with metastasis [37]."
39934701
EIF3F affects NUP42
| 1
NUP42 binds NUP155 and EIF3F. 1 / 1
| 1
sparser
"Furthermore, the hCG1, Nup155 and eIF3f interactions were not perturbed by the PFQ insertion ( xref )."
24243016
EIF3F affects NTRK1
1 |
NTRK1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
25921289
EIF3F affects NPM1
1 |
NPM1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3F affects NONO
1 |
EIF3F binds NONO. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects NLRP3
1 |
NLRP3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33243234
EIF3F affects NFX1
1 |
NFX1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31059266
EIF3F affects NCT503
| 1
NCT503 binds EIF3F. 1 / 1
| 1
reach
"These data indicate that EIF3F is a transcriptional target of the Wnt signaling pathway via β‐catenin/TCF4 binding to the EIF3F promoter.2.7 Combination Treatment of NCT503 and LGK-974 Mitigated Tumor Growth in eIF3f High Human PDX CRC Models with Better Efficacy through Hindering Wnt-eIF3f-PHGDH Signaling Axis."
37544925
EIF3F affects Muscles
| 1
EIF3F activates Muscles. 1 / 1
| 1
eidos
"Furthermore , in mouse models , eIF3f depletion impedes embryonic development , reduces adult skeletal muscle mass and amplifies muscle loss during disuse [ 18 ] ."
31728542
EIF3F affects Melanoma
| 1
EIF3F activates Melanoma. 1 / 1
| 1
reach
"EIF3f induces apoptosis by inhibiting protein synthesis and proliferation in pancreatic cancer and melanoma cells, whereas eIF3f may act as a negative regulator of translational effects, and its low expression protects melanoma cells from apoptosis [67]."
36360287
EIF3F affects MYDGF
1 |
MYDGF binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3F affects MTSS1
1 |
MTSS1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35122005
EIF3F affects MSMO1
1 |
EIF3F binds MSMO1. 1 / 1
1 |
biogrid
No evidence text available
22939629
EIF3F affects MPC2
1 |
EIF3F binds MPC2. 1 / 1
1 |
biogrid
No evidence text available
33961781
EIF3F affects MKRN2
1 |
MKRN2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3F affects MKI67
| 1
EIF3F increases the amount of MKI67. 1 / 1
| 1
reach
"The IHC analysis of the xenograft tissues exhibited that inhibiting eIF3f reduced Ki67 expression, indicating decreased proliferation of tumor cells (XREF_FIG - XREF_FIG)."
32440143
EIF3F affects MEPCE
1 |
MEPCE binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29845934
EIF3F affects MECP2
1 |
MECP2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
38697112
EIF3F affects MAPT
1 |
MAPT binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
36634849
EIF3F affects MAPK
| 1
EIF3F leads to the dephosphorylation of MAPK. 1 / 1
| 1
reach
"Furthermore, specific repression of eIF3f did not induce significant changes in either the levels or the phosphorylation of the mitogen activated protein kinases Erk1 and Erk2 and PKB and Akt (XREF_FIG)."
20126553
EIF3F affects MAP1B
1 |
EIF3F binds MAP1B. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects MAK
1 |
MAK binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32707033
EIF3F affects M
1 |
EIF3F binds M. 1 / 1
1 |
virhostnet
No evidence text available
25464832
EIF3F affects Ksr1
1 |
Ksr1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26549023
EIF3F affects KRT9
1 |
EIF3F binds KRT9. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects KRT8
1 |
EIF3F binds KRT8. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects KRT6B
1 |
EIF3F binds KRT6B. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects KRT2
1 |
EIF3F binds KRT2. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects KRT14
1 |
EIF3F binds KRT14. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects KRT10
1 |
EIF3F binds KRT10. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects KRT1
1 |
EIF3F binds KRT1. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects KLHL20
1 |
KLHL20 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26687681
EIF3F affects KLF16
1 |
KLF16 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35140242
EIF3F affects KIF11
1 |
EIF3F binds KIF11. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects KAT6A
1 |
KAT6A binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
36537216
EIF3F affects K48
| 1
EIF3F binds ACSL4 and K48. 1 / 1
| 1
reach
"EIF3f directly interacted with and stabilised long chain acyl CoA synthetase 4 (ACSL4) through K48-linked deubiquitination, promoting fatty acid biosynthesis (FAB) and tumour malignancy."
40154622
EIF3F affects Itsn2
1 |
Itsn2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3F affects IMMT
1 |
EIF3F binds IMMT. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3F affects IGKV2D-29
1 |
EIF3F binds IGKV2D-29. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects HTR2A
1 |
HTR2A binds EIF3F. 1 / 1
1 |
hprd
No evidence text available
16537434
EIF3F affects HSPA8
1 |
EIF3F binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects HNRNPU
1 |
EIF3F binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects HDAC6
1 |
HDAC6 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35676659
EIF3F affects HDAC5
1 |
HDAC5 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
21081666
EIF3F affects HA
1 |
EIF3F binds HA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
EIF3F affects GTP
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L increases the amount of GTP bound to Met-tRNA(Met), EIF2S1, EIF2S2, and EIF2S3. 1 / 1
1 |
signor
"EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit"
17581632
EIF3F affects GTF2E2
1 |
EIF3F binds GTF2E2. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects GSTA5
1 |
GSTA5 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33961781
EIF3F affects GSK3B
| 1
EIF3F leads to the dephosphorylation of GSK3B. 1 / 1
| 1
reach
"In addition, eIF3f decreased the phosphorylation of GSK-3beta and expression of Elk-1 and Egr-1, downstream factors of Akt and ERK, respectively."
26988917
EIF3F affects GPX1
| 1
EIF3F binds GPX1. 1 / 1
| 1
sparser
"For example, eIF3e, f, and g have similar molecular weights, but no crosslinking signal could be observed between eIF3f and GPx1 mRNA because Western blot and radioactivity signals do not overlay ( xref d), showing that eIF3f does not interact with GPx1 mRNA."
36139107
EIF3F affects G3BP2
1 |
G3BP2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3F affects FOXO1
1 |
FOXO1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
36964488
EIF3F affects FLVCR1
| 1
EIF3F inhibits FLVCR1. 1 / 1
| 1
reach
"Similarly, the downregulation of eIF3f expression reduces Akt levels, inhibiting PCa growth and progression (54)."
35856412
EIF3F affects FLNA
1 |
EIF3F binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F activates Embryonic Development. 1 / 1
| 1
eidos
"Furthermore , in mouse models , eIF3f depletion impedes embryonic development , reduces adult skeletal muscle mass and amplifies muscle loss during disuse [ 18 ] ."
31728542
EIF3F affects Eif3i
1 |
Eif3i binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3F affects ESR2
1 |
ESR2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29509190
EIF3F affects ERCC8
| 1
EIF3F activates ERCC8. 1 / 1
| 1
reach
"Because the higher mortality of heterozygous eIF3f mice remains to be explained, further studies investigating cardiac morphology and function of our animal model are needed to clarify the involvement of eIF3f in cardiac homeostasis.In the present study, we report that eIF3f down-regulation significantly decreases skeletal muscle mass by reducing CSA without affecting fibre number and the expression of fibre type specific myosins."
31026345
EIF3F affects ERCC6
1 |
ERCC6 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31722399
EIF3F affects EP300
1 |
EP300 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
33742100
EIF3F affects EML2
1 |
EML2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3F affects ELK1
| 1
EIF3F leads to the dephosphorylation of ELK1. 1 / 1
| 1
reach
"In addition, eIF3f decreased the phosphorylation of GSK-3beta and expression of Elk-1 and Egr-1, downstream factors of Akt and ERK, respectively."
26988917
EIF3F affects EIF4ENIF1
1 |
EIF3F binds EIF4ENIF1. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF3F affects EIF4EBP2
1 |
EIF4EBP2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF3F affects EIF3J
1 |
EIF3F binds EIF3J. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3F affects EIF1
1 |
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L activates EIF1. 1 / 1
1 |
signor
"EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit"
17581632
EIF3F affects EGFR
1 |
EGFR binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
24797263
EIF3F affects E
1 |
E binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
38569033
EIF3F activates Dermatitis, Atopic. 1 / 1
| 1
reach
"In this study, berberine inhibited the expression of MALT1 and EIF3F and subsequently suppressed the production of MIF and IL-4, suggesting that the regulation of MALT1 and EIF3F is involved in the at[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33539814
EIF3F affects DYRK3
1 |
DYRK3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32707033
EIF3F affects DND1
| 1
DND1 binds EIF3F. 1 / 1
| 1
sparser
"We previously found that Dnd1 directly interacts with eIF3f, and through it, the whole eIF3 complex, which is required to initiate translation ( xref )."
30230100
EIF3F affects DDX1
1 |
EIF3F binds DDX1. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects Cap
| 1
EIF3F activates Cap. 1 / 1
| 1
reach
"EIF3f Activates the Cap Dependent Translation in Muscle Cells."
20126553
EIF3F affects CYLD
1 |
CYLD binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
27591049
EIF3F affects CUL3
1 |
CUL3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35563538
EIF3F affects CSNK2A3
1 |
CSNK2A3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
36736316
EIF3F affects COL1A2
1 |
COL1A2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3F affects COIL
1 |
COIL binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
34079125
EIF3F affects CIT
1 |
CIT binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31586073
EIF3F affects CIC
1 |
CIC binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29844126
EIF3F affects CHD4
1 |
CHD4 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
28977666
EIF3F affects CHD3
1 |
CHD3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
28977666
EIF3F affects CFTR
1 |
CFTR binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26618866
EIF3F affects CDSN
1 |
EIF3F binds CDSN. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3F affects CDK11-9G8
| 1
EIF3F binds CDK11-9G8. 1 / 1
| 1
reach
"Interestingly, overexpression of eIF3f or just its N-terminal 91 amino acid fragment disrupts the eIF3f and CDK11-9G8 complex and prevents efficient 3 ' processing at the 3 ' LTR, leading to reduced viral replication 113."
21957020
EIF3F affects CDC123
1 |
CDC123 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37314216
EIF3F affects CD81
1 |
CD81 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
23463506
EIF3F affects C9orf72
1 |
C9orf72 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37317656
EIF3F affects BTG3
1 |
BTG3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35914814
EIF3F affects BRD4
1 |
BRD4 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32416067
EIF3F affects BMI1
1 |
BMI1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
34316702
EIF3F affects BAP1
1 |
BAP1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35446349
EIF3F affects Apc2
1 |
Apc2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32129710
EIF3F affects AURKA
1 |
EIF3F binds AURKA. 1 / 1
1 |
biogrid
No evidence text available
33669244
EIF3F affects ATXN1
1 |
ATXN1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
23275563
EIF3F affects ATP6V1A
1 |
EIF3F binds ATP6V1A. 1 / 1
1 |
biogrid
No evidence text available
22939629
EIF3F affects APP
1 |
EIF3F binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
EIF3F affects ANXA2
1 |
EIF3F binds ANXA2. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects ANK3
1 |
ANK3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
34079125
EIF3F affects AIFM1
1 |
AIFM1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
40437099
EIF3F affects ACTN4
1 |
EIF3F binds ACTN4. 1 / 1
1 |
biogrid
No evidence text available
31527668
EIF3F affects AATF
1 |
AATF binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31363146
EIF3F affects (S) protein
| 1
(S) protein binds EIF3F. 1 / 1
| 1
reach
"In addition, the spike (S) protein of SARS-CoV and infectious bronchitis virus (IBV) can interact with eIF3f to inhibit host translation."
29173589
EIF3E affects EIF3K
| 1
EIF3E binds EIF3F and EIF3K. 1 / 1
| 1
sparser
"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
26399914
EIF3A affects EIF3D, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, and EIF3K
| 1
EIF3A binds EIF3D, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, and EIF3K. 1 / 1
| 1
sparser
"In , it has also been shown that eIF3a interacts with eIF3d, eIF3f, eIF3g, eIF3h , eIF3i , eIF3j and eIF3k ."
20647036
EIF3A affects EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, and EIF3K
1 |
EIF3A binds EIF3E, EIF3K, EIF3J, EIF3I, EIF3H, EIF3G, EIF3F, EIF3D, EIF3C, and EIF3B. 1 / 1
1 |
hprd
No evidence text available
14519125
EGFR affects EIF3F
1 |
EGFR binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
24797263
E3_Ub_ligase affects EIF3F
| 1
E3_Ub_ligase inhibits EIF3F. 1 / 1
| 1
reach
"The reduced Akt1 kinase activity observed upon statins treatment, resulted in an increase in dephosphorylation on FoxO3 and FoxO1 transcription factors, their translocation into the nucleus, and activation of the Atrogin1 and MAFbx gene encoding ubiquitin ligase E3, which eliminates MyoD, calcineurin, eIF3-F translation initiator, and FoxO1 [XREF_BIBR]."
30241315
E affects EIF3F
1 |
E binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
38569033
Dronabinol affects EIF3F
1 |
Dronabinol increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
30283037
DYRK3 affects EIF3F
1 |
DYRK3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32707033
DDX1 affects EIF3F
1 |
EIF3F binds DDX1. 1 / 1
1 |
biogrid
No evidence text available
31527668
Caspase affects Thr-119
| 1
Caspase binds EIF3F and Thr-119. 1 / 1
| 1
reach
"Moreover, caspase processed isoform of the cell division kinase 11 (Cdk11 p46) binds and phosphorylates eIF3f at Ser 46 and Thr 119 during apoptosis in A375 melanoma cells, leading to an inhibition of translation."
23769948
CYLD affects EIF3F
1 |
CYLD binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
27591049
CUL3 affects EIF3F
1 |
CUL3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35563538
CSNK2A3 affects EIF3F
1 |
CSNK2A3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
36736316
COL1A2 affects EIF3F
1 |
COL1A2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32296183
COIL affects EIF3F
1 |
COIL binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
34079125
CIT affects EIF3F
1 |
CIT binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31586073
CIC affects EIF3F
1 |
CIC binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
29844126
CHD4 affects EIF3F
1 |
CHD4 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
28977666
CHD3 affects EIF3F
1 |
CHD3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
28977666
CFTR affects EIF3F
1 |
CFTR binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
26618866
CDSN affects EIF3F
1 |
EIF3F binds CDSN. 1 / 1
1 |
biogrid
No evidence text available
32296183
CDK11-9G8 affects EIF3F
| 1
EIF3F binds CDK11-9G8. 1 / 1
| 1
reach
"Interestingly, overexpression of eIF3f or just its N-terminal 91 amino acid fragment disrupts the eIF3f and CDK11-9G8 complex and prevents efficient 3 ' processing at the 3 ' LTR, leading to reduced viral replication 113."
21957020
CDC123 affects EIF3F
1 |
CDC123 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37314216
CD81 affects EIF3F
1 |
CD81 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
23463506
C9orf72 affects EIF3F
1 |
C9orf72 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
37317656
BTG3 affects EIF3F
1 |
BTG3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35914814
BRD4 affects EIF3F
1 |
BRD4 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32416067
BMI1 affects EIF3F
1 |
BMI1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
34316702
BAP1 affects EIF3F
1 |
BAP1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
35446349
Apc2 affects EIF3F
1 |
Apc2 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
32129710
AURKA affects EIF3F
1 |
EIF3F binds AURKA. 1 / 1
1 |
biogrid
No evidence text available
33669244
ATXN1 affects EIF3F
1 |
ATXN1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
23275563
ATP6V1A affects EIF3F
1 |
EIF3F binds ATP6V1A. 1 / 1
1 |
biogrid
No evidence text available
22939629
APP affects EIF3F
1 |
EIF3F binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
ANXA2 affects EIF3F
1 |
EIF3F binds ANXA2. 1 / 1
1 |
biogrid
No evidence text available
31527668
ANK3 affects EIF3F
1 |
ANK3 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
34079125
AIFM1 affects EIF3F
1 |
AIFM1 binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
40437099
ACVR2B affects EIF3F
| 1
ACVR2B inhibits EIF3F. 1 / 1
| 1
reach
"The loss of p70S6k and eIF3f expression was not seen in immobilized mice treated with ActRIIB (XREF_FIG)."
24504412
ACTN4 affects EIF3F
1 |
EIF3F binds ACTN4. 1 / 1
1 |
biogrid
No evidence text available
31527668
ACSL4 affects K48
| 1
EIF3F binds ACSL4 and K48. 1 / 1
| 1
reach
"EIF3f directly interacted with and stabilised long chain acyl CoA synthetase 4 (ACSL4) through K48-linked deubiquitination, promoting fatty acid biosynthesis (FAB) and tumour malignancy."
40154622
AATF affects EIF3F
1 |
AATF binds EIF3F. 1 / 1
1 |
biogrid
No evidence text available
31363146
(S) protein affects EIF3F
| 1
(S) protein binds EIF3F. 1 / 1
| 1
reach
"In addition, the spike (S) protein of SARS-CoV and infectious bronchitis virus (IBV) can interact with eIF3f to inhibit host translation."
29173589
(-)-epigallocatechin 3-gallate decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
31195006
4,4'-hexafluorisopropylidene diphenol increases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
34186270
3,3',4,4',5-pentachlorobiphenyl decreases the amount of EIF3F. 1 / 1
1 |
ctd
No evidence text available
28973690