IndraLab
Statements
EIF3F is modified
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EIF3F is phosphorylated.
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"Phosphorylated eIF3F seems to facilitate the formation of immature-nonfunctional eIF3 complex since the phosphorylated eIF3F does not exist in free form at both interphase and M phase as shown in the fraction D of Fig. S6. (2) Phosphorylated eIF3F may make a complex with an unknown protein, which in turn induces translational repression during M phase."
sparser
"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase-processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [ xref ] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation (Fig. xref )."
EIF3F is ubiquitinated.
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3
sparser
"Hence any reports describing pathological phenotypes stemming from altered expression of these three subunits should be at least partially regarded as a failure of the dramatically compromised eIF3 complex to ensure productive general translation initiation in sick cells; like underexpression of eIF3f in gastric, melanoma and pancreatic cancers supposedly deregulating apoptosis ( xref , xref ), eIF3f ubiquitination and proteosomal degradation during muscle atrophy ( xref ), overexpression of eIF3m in human cancer cell lines and colon cancer patient tissues ( xref ), as well as overexpression of eIF3c in testicular seminoma cells ( xref )."
EIF3F is acetylated.
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Spike glycoprotein affects EIF3F
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Spike glycoprotein binds EIF3F.
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Spike glycoprotein inhibits EIF3F.
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Spike glycoprotein inhibits EIF3F. 3 / 3
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"The staining patterns of the two proteins are well overlapped (Fig. 1c, panel E), suggesting that the S protein may sequester the eIF3f to the cytoplasm.The interaction between SARS-CoV S protein and eIF3f was further investigated by checking if the two proteins could form complexes in vitro."
EIF3F affects apoptotic process
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52
EIF3F activates apoptotic process.
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40
EIF3F inhibits apoptotic process.
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"Because the phosphorylation of the
hydrophobic motif at T389 in S6K1 has been shown to regulate the interaction
between S6K1 and the eIF3-PIC complex xref , this prompted us to
examine the phosphorylation state of S6K1 that physically interacts with eIF3f
by using a GST pull down assay with total cellular extracts from normal myotubes
and/or atrophied myotubes."
sparser
"Since eIF3f serves as a connecting platform between mTOR-raptor and S6K1 in
muscle cells ( xref ) and
mutation of the C-terminal lysines in eIF3f increases phosphorylation of S6K1,
we assessed the binding affinities of both eIF3f wt and mutant eIF3f
K 5–10 R proteins with S6K1 and mTOR-raptor."
reach
"In contrast, HA tagged eIF3f mutant K 5-10 R overexpressed in mouse primary myotubes at 4 th day of differentiation was able to bind both endogenous mTOR and raptor by about 2-fold higher than HA tagged eIF3f wt leading to a higher phosphorylation and activity of S6K1 as evidenced by an increased phosphorylation of rpS6 on Ser235/236 residues (XREF_FIG)."
EIF3F affects translation
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EIF3F inhibits translation.
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EIF3F activates translation.
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EIF3F activates translation. 8 / 8
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reach
"Hence any reports describing pathological phenotypes stemming from altered expression of these three subunits should be at least partially regarded as a failure of the dramatically compromised eIF3 complex to ensure productive general translation initiation in sick cells; like underexpression of eIF3f in gastric, melanoma and pancreatic cancers supposedly deregulating apoptosis, eIF3f ubiquitination and proteosomal degradation during muscle atrophy, overexpression of eIF3m in human cancer cell lines and colon cancer patient tissues, as well as overexpression of eIF3c in testicular seminoma cells."
Mutated EIF3F activates translation. 1 / 1
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1
reach
"Although our preliminary data did not show major posttranslational modifications of eIF3f during muscle differentiation, it is possible that mTOR directly phosphorylates eIF3f and we are currently pursuing this line of investigation to see whether there is any mTOR dependent and rapamycin sensitive phosphorylation sites within eIF3f."
sparser
"Although our preliminary data did not show major posttranslational modifications of
eIF3f during muscle differentiation, it is possible that mTOR directly
phosphorylates eIF3f and we are currently pursuing this line of investigation to see
whether there is any mTOR-dependent and rapamycin-sensitive phosphorylation sites
within eIF3f."
sparser
"This work also showed that p70S6K1 interacts with, and phosphorylates eIF3f, leading the authors to suggest that p70S6K1 phosphorylates eIF3 to stimulate the Paip1-eIF3 interaction and promotes translation initiation. xref Whether mTOR or p70S6K directly phosphorylates eIF3f in C2C12 cells or the effects of ablation of eIF3f on differentiation are unknown at this time."
sparser
"Because the phosphorylation of the
hydrophobic motif at T389 in S6K1 has been shown to regulate the interaction
between S6K1 and the eIF3-PIC complex xref , this prompted us to
examine the phosphorylation state of S6K1 that physically interacts with eIF3f
by using a GST pull down assay with total cellular extracts from normal myotubes
and/or atrophied myotubes."
sparser
"This work also showed that p70S6K1 interacts with, and phosphorylates eIF3f, leading the authors to suggest that p70S6K1 phosphorylates eIF3 to stimulate the Paip1-eIF3 interaction and promotes translation initiation. xref Whether mTOR or p70S6K directly phosphorylates eIF3f in C2C12 cells or the effects of ablation of eIF3f on differentiation are unknown at this time."
sparser
"To test whether eIF3f and eIF3h actually interact with the eIF4GI682-1130-MS2 fusion protein, we co-expressed both factors transiently in HEK 293T cells, immunoprecipitated the eIF4G core domain via its MS2 fusion in presence of RNase A and tested for its association of eIF3f and eIF3h ( xref )."
reach
"Based on the convincing fit of the eIF3a and eIF3c structure into the EM density, we attempted to dock the recently solved paralogs of eIF3e (CSN1) and the eIF3h and eIF3f heterodimer (Rpn8 and Rpn11) into the eIF3.IRES EM density along with older models for eIF3k, eIF3m, and eIF3l (XREF_FIG A)."
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
EIF3F affects cell population proliferation
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EIF3F inhibits cell population proliferation.
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EIF3F inhibits cell population proliferation. 10 / 21
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"Recent reports on the biological function of eIF3f in translation and apoptosis in tumor cells demonstrated that eIF3f is down regulated in most human tumors and that overexpression of eIF3f inhibited cell proliferation suggesting a function associated with differentiation XREF_BIBR."
reach
"Previous studies have demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that downregulation of eIF3f is involved in tumorigenesis for many types of cancer [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
reach
"In our current study, we found evidence that stable knockdown of eIF3f in normal human pancreatic ductal epithelial cells increased cell size, nuclear pleomorphism, cytokinesis defects, cell proliferation, clonogenicity, apoptotic resistance, migration, and formation of 3-dimensional irregular masses."
EIF3F activates cell population proliferation.
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sparser
"To test whether eIF3f and eIF3h actually interact with the eIF4GI682-1130-MS2 fusion protein, we co-expressed both factors transiently in HEK 293T cells, immunoprecipitated the eIF4G core domain via its MS2 fusion in presence of RNase A and tested for its association of eIF3f and eIF3h ( xref )."
reach
"Based on the convincing fit of the eIF3a and eIF3c structure into the EM density, we attempted to dock the recently solved paralogs of eIF3e (CSN1) and the eIF3h and eIF3f heterodimer (Rpn8 and Rpn11) into the eIF3.IRES EM density along with older models for eIF3k, eIF3m, and eIF3l (XREF_FIG A)."
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
reach
"Finally, to substantiate the role of Mss4 and eIF3f interaction in protection of stress induced apoptosis, we transiently transfected divergent A7 melanoma cell lines that constitutively expressed different levels of either endogenous, recombinant wt or F75A mutated Mss4 proteins (XREF_FIG) with a plasmid coding for human eIF3f and subsequently subjected them to hydrogen peroxide stress for 8h."
sparser
"Molecular analysis of the Mss4-mediated inhibition of apoptosis showed that interaction of Mss4 with eIF3f (eukaryotic translation initiation factor 3 subunit f), a member of the translation initiation complex and a protein with distinct pro-apoptotic properties, is the critical event in the anti-apoptotic action of Mss4."
sparser
"Moreover, enhanced expression of Mss4 in A7 melanoma cells neutralized the translation inhibitory effect of eIF3f, implying that association of eIF3f with Mss4 is of importance in protection of cells from apoptosis and that the anti-apoptotic properties of Mss4 are based on prevention of translation inhibition by eIF3f."
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR To study whether Mss4 is capable to abolish this specific property of eIF3f protein, A7 melanoma cells were transfected with pCS2+ MT empty vector, pCS2+ MT-Mss4 and pCS2+ MT-eIF3f or both plasmids together in addition to pRL-CMV vector in which the luciferase reporter gene is controlled by the CMV promoter."
sparser
"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
sparser
"Our findings are in line with previous observations reporting that endogenous eIF3f can localize at both cytoplasm and nuclear levels. xref During apoptosis, endogenous eIF3f is phosphorylated by CDK11 which is mainly a nuclear protein xref , xref and can assembly with other eIF3 subunits to form nuclear complexes which are involved in functions other than translation initiation, such as ribosome biogenesis that takes place into nucleus. xref The observation of nuclear localization together with the apoptotic effect observed by Annexin V assay strongly suggests that the exogenous and endogenous eIF3f are subjected to similar intracellular processing."
EIF3F affects cell growth
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EIF3F inhibits cell growth.
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EIF3F activates cell growth.
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"Finally, to substantiate the role of Mss4 and eIF3f interaction in protection of stress induced apoptosis, we transiently transfected divergent A7 melanoma cell lines that constitutively expressed different levels of either endogenous, recombinant wt or F75A mutated Mss4 proteins (XREF_FIG) with a plasmid coding for human eIF3f and subsequently subjected them to hydrogen peroxide stress for 8h."
sparser
"Molecular analysis of the Mss4-mediated inhibition of apoptosis showed that interaction of Mss4 with eIF3f (eukaryotic translation initiation factor 3 subunit f), a member of the translation initiation complex and a protein with distinct pro-apoptotic properties, is the critical event in the anti-apoptotic action of Mss4."
sparser
"Moreover, enhanced expression of Mss4 in A7 melanoma cells neutralized the translation inhibitory effect of eIF3f, implying that association of eIF3f with Mss4 is of importance in protection of cells from apoptosis and that the anti-apoptotic properties of Mss4 are based on prevention of translation inhibition by eIF3f."
reach
"21 During apoptosis, endogenous eIF3f is phosphorylated by CDK11 which is mainly a nuclear protein XREF_BIBR, XREF_BIBR and can assembly with other eIF3 subunits to form nuclear complexes which are involved in functions other than translation initiation, such as ribosome biogenesis that takes place into nucleus."
"The interaction between cdk11p46 and eif3 p47 occurs in vitro and in vivo. In addition, cdk11 protein kinase isolated from cells undergoing apoptosis can phosphorylate eif3 p47in vitro, and serine phosphorylation of eif3 p47 occurs in cells during apoptosis.Purified recombinant cdk11p46 inhibited translation of a reporter gene in vitro in a dose-dependent manner.These data suggest that the function of the caspase-processed cdk11p110 isoform may be to inhibit translation during apoptosis. However, whether or not this inhibition of protein translation occurs in an eif3 p47-dependent or -independent manner remains to be clarified."
"Here, we identified a second eif3f phosphorylation site (thr119) by cdk11p46 during apoptosis.Thr119 is located in the mov34 domain of eif3f which is important for both the translational inhibitory function of eif3ffurther studies of how eif3f phosphorylation regulates its function will refine insights into the mechanism and regulation of translation initiation, apoptotic signaling, and tumorigenesis."
"The interaction between cdk11p46 and eif3 p47 occurs in vitro and in vivo. In addition, cdk11 protein kinase isolated from cells undergoing apoptosis can phosphorylate eif3 p47in vitro, and serine phosphorylation of eif3 p47 occurs in cells during apoptosis.Purified recombinant cdk11p46 inhibited translation of a reporter gene in vitro in a dose-dependent manner.These data suggest that the function of the caspase-processed cdk11p110 isoform may be to inhibit translation during apoptosis. However, whether or not this inhibition of protein translation occurs in an eif3 p47-dependent or -independent manner remains to be clarified."
CDK11 p46 affects EIF3F
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18
reach
"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
sparser
"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
"The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor."
"The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor."
EIF3F affects phenazine-1-carboxylate
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9
EIF3F activates phenazine-1-carboxylate.
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EIF3F inhibits phenazine-1-carboxylate.
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EIF3F inhibits phenazine-1-carboxylate. 1 / 1
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"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
EIF3F affects adrenoceptor
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7
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"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
sparser
"RHEB (Ras homolog enriched in brain) activates mTORC1 (mechanistic/mammalian target of rapamycin complex 1), which binds to the scaffold protein eIF3f (eukaryotic initiation factor 3f ) through a TOS (TOR signaling) motif and modulates mRNA translation by phosphorylating eIF3f bound-S6K1 (S6 kinase 1) and 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1)."
| PMC
EIF3F affects 9G8
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9G8 affects EIF3F
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sparser
"RHEB (Ras homolog enriched in brain) activates mTORC1 (mechanistic/mammalian target of rapamycin complex 1), which binds to the scaffold protein eIF3f (eukaryotic initiation factor 3f ) through a TOS (TOR signaling) motif and modulates mRNA translation by phosphorylating eIF3f bound-S6K1 (S6 kinase 1) and 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1)."
| PMC
EIF3F inhibits growth.
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4
eidos
"Additionally , iRhom2 protein assembles the deubiquitinase eukaryotic translation initiation factor 3S5 ( EIF3S5 ) , which acts to promote STING during this process.117 STING relocation from the ER and interaction with TBK1 in the perinuclear area , prompts the activation of IRF3 through phosphorylation.120 TBK1 phosphorylates the tail domain of the carboxy-terminal from STING , resulting in the assembly of IRF3 and its subsequent phosphorylation ."
"The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor."
"The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor."
CDK11p46 affects EIF3F
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Heterogeneous nuclear ribonucleoprotein affects EIF3F
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EIF3F affects sCLU
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EIF3F affects heterogeneous nuclear ribonucleoprotein
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EIF3F affects Hypertrophy
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EIF3F affects DTrc8
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sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
reach
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [XREF_BIBR], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [XREF_BIBR]."
EIF3F affects rRNA catabolic process
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EIF3F inhibits rRNA catabolic process.
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EIF3F activates rRNA catabolic process.
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EIF3F activates rRNA catabolic process. 1 / 1
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EIF3F affects cell death
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"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
reach
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [XREF_BIBR], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [XREF_BIBR]."
DTrc8 affects EIF3F
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"RHEB (Ras homolog enriched in brain) activates mTORC1 (mechanistic/mammalian target of rapamycin complex 1), which binds to the scaffold protein eIF3f (eukaryotic initiation factor 3f ) through a TOS (TOR signaling) motif and modulates mRNA translation by phosphorylating eIF3f bound-S6K1 (S6 kinase 1) and 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1)."
| PMC
HnRNP affects EIF3F
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Heterogeneous nuclear ribonucleoprotein affects RNA-binding
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2
Cadmium dichloride affects EIF3F
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Thr-119 affects EIF3F
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SDeltaC affects EIF3F
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"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
RNA-directed RNA polymerase NS5 affects EIF3F
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RNA-binding affects heterogeneous nuclear ribonucleoprotein
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Proteasome affects EIF3F
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Pool 2 affects EIF3F
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M affects EIF3F
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"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
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EIF3F translocates.
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EIF3F is inactive.
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"The interaction between cdk11p46 and eif3 p47 occurs in vitro and in vivo. In addition, cdk11 protein kinase isolated from cells undergoing apoptosis can phosphorylate eif3 p47in vitro, and serine phosphorylation of eif3 p47 occurs in cells during apoptosis.Purified recombinant cdk11p46 inhibited translation of a reporter gene in vitro in a dose-dependent manner.These data suggest that the function of the caspase-processed cdk11p110 isoform may be to inhibit translation during apoptosis. However, whether or not this inhibition of protein translation occurs in an eif3 p47-dependent or -independent manner remains to be clarified."
EIF3F affects tumor growth
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"RHEB (Ras homolog enriched in brain) activates mTORC1 (mechanistic/mammalian target of rapamycin complex 1), which binds to the scaffold protein eIF3f (eukaryotic initiation factor 3f ) through a TOS (TOR signaling) motif and modulates mRNA translation by phosphorylating eIF3f bound-S6K1 (S6 kinase 1) and 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1)."
| PMC
EIF3F affects ribosomal RNA
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EIF3F inhibits ribosomal RNA. 2 / 2
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eidos
"Notably , the eIF3f level was reportedly reduced in pancreatic cancer , and overexpression of eIF3f in pancreatic cancer cells resulted in apoptosis ; 33moreover , eIF3f promoted rRNA degradation and inhibited translation.34eIF3f has been shown to act as a tumor suppressor in melanoma.35 ,36 In patients with gastric cancer , reduced expression of eIF3f was associated with poor prognosis , and eIF3f presumably plays an important role in gastric cancer recurrence.37-39However , it remains controversial whether eIF3f acts as an oncogene or a suppressor ."
EIF3F affects replication
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EIF3F affects protein synthesis
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EIF3F affects hnRNP
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EIF3F affects expression
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EIF3F affects cytokinesis
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EIF3F inhibits cytokinesis. 2 / 2
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"In our current study, we found evidence that stable knockdown of eIF3f in normal human pancreatic ductal epithelial cells increased cell size, nuclear pleomorphism, cytokinesis defects, cell proliferation, clonogenicity, apoptotic resistance, migration, and formation of 3-dimensional irregular masses."
EIF3F affects Thr-119
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EIF3F affects SDeltaC
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EIF3F affects RNA-directed RNA polymerase NS5
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EIF3F affects RNA-binding, and heterogeneous nuclear ribonucleoprotein
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EIF3F affects PCa cells
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EIF3F affects NS5
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EIF3F affects M
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sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
EIF3F affects E protein
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"We found that LAMR1 could interact with UPS13 (Figure 5a, lane 2) and EIF3S5 (Figure 5a, lane 9), but not with the control (Figure 5a, lane 1) or other proteins (Figure 5a, lanes 3–8, and 10), suggesting that EIF3S5 and UPS13 might be involved in the LAMR1-mediated deubiquitination of E protein."
reach
"The same effect was reached in colorectal carcinoma cells lacking of p53 (HCT116 p53 -/-) in about 1 hour for MD 11 -K510R, 1.5 hours for MD 11 -NF and 3 hours for MD 11 -wt eIF3f, confirming that this cell line is more resistant than wild-type to the death stimulus and that p53 may play a role in eIF3f induced death (XREF_FIG)."
EIF3F affects Carcinogenesis
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EIF3F affects CDK11p46
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EIF3F affects CDK11 p46
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E3_Ub_ligase affects EIF3F
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E3_Ub_ligase inhibits EIF3F.
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E3_Ub_ligase inhibits EIF3F. 1 / 1
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"The reduced Akt1 kinase activity observed upon statins treatment, resulted in an increase in dephosphorylation on FoxO3 and FoxO1 transcription factors, their translocation into the nucleus, and activation of the Atrogin1 and MAFbx gene encoding ubiquitin ligase E3, which eliminates MyoD, calcineurin, eIF3-F translation initiator, and FoxO1 [XREF_BIBR]."
E3_Ub_ligase activates EIF3F.
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E3_Ub_ligase activates EIF3F. 1 / 1
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Caspase affects Thr-119
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Valproic acid affects EIF3F
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Triphenyl phosphate affects EIF3F
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sparser
"RHEB (Ras homolog enriched in brain) activates mTORC1 (mechanistic/mammalian target of rapamycin complex 1), which binds to the scaffold protein eIF3f (eukaryotic initiation factor 3f ) through a TOS (TOR signaling) motif and modulates mRNA translation by phosphorylating eIF3f bound-S6K1 (S6 kinase 1) and 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1)."
| PMC
Titanium dioxide affects EIF3F
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Thimerosal affects EIF3F
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Sodium fluoride affects EIF3F
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Sodium arsenite affects EIF3F
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Sodium arsenate affects EIF3F
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Raptor-mTOR affects EIF3F
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Protein affects EIF3F
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"Notably, VPg of caliciviruses binds to eIF3, spike protein of severe acute respiratory syndrome coronavirus (SARS-CoV) and infectious bronchitis virus (IBV) binds to eIF3F, and matrix protein of rabies virus interacts with eIF3 complex and, in all cases, the binding facilitates viral mRNA translation and/or inhibits host cell translation."
Protein 1 affects EIF3F
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sparser
"Except for the directly connected and stress-related GTP-binding nuclear protein (RAN1; Jiang et al., xref ), other connections including 17 ribosomal proteins [e.g., 60S ribosomal protein L14-2 (RPL14B), 40S ribosomal protein S15-1 (RPS15) and 40S ribosomal protein S15-4 (RPS15D)], and actin-11 (ACT11), ADP/ATP carrier protein 1 (AAC1) and eukaryotic translation initiation factor 3 subunit F (TIF3F1) formed tertiary nodes."
Progesterone affects EIF3F
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Potassium chromate affects EIF3F
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Phosphate(3-) affects EIF3F
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Phosphate(3-) leads to the phosphorylation of EIF3F. 1 / 1
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Paracetamol affects EIF3F
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Nickel acetate affects EIF3F
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Methylmercury chloride affects EIF3F
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Methyl methanesulfonate affects EIF3F
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Mercury(0) affects EIF3F
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sparser
"RHEB (Ras homolog enriched in brain) activates mTORC1 (mechanistic/mammalian target of rapamycin complex 1), which binds to the scaffold protein eIF3f (eukaryotic initiation factor 3f ) through a TOS (TOR signaling) motif and modulates mRNA translation by phosphorylating eIF3f bound-S6K1 (S6 kinase 1) and 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1)."
| PMC
Ketone body affects EIF3F
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Indometacin affects EIF3F
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Hsa-miR-6889-3p affects EIF3F
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Hsa-miR-6807-5p affects EIF3F
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Hsa-miR-661 affects EIF3F
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Hsa-miR-550b-2-5p affects EIF3F
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Hsa-miR-550a-5p affects EIF3F
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Hsa-miR-550a-3-5p affects EIF3F
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Hsa-miR-4436b-5p affects EIF3F
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Hsa-miR-4252 affects EIF3F
1
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Hsa-miR-320a affects EIF3F
1
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Hsa-miR-3116 affects EIF3F
1
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Hsa-miR-16-5p affects EIF3F
1
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Hsa-miR-155-5p affects EIF3F
1
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Hsa-miR-149-5p affects EIF3F
1
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Hsa-miR-1271-3p affects EIF3F
1
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Hsa-miR-1254 affects EIF3F
1
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Hsa-miR-106b-5p affects EIF3F
1
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Heterogenous nuclear ribonucleoprotein K affects EIF3F
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1
HGle1 affects EIF3F
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1
HCG1 affects EIF3F
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1
Gentamycin affects EIF3F
1
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Folic acid affects EIF3F
1
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EIF3 protein complex affects EIF3F
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1
EIF3 core affects EIF3F
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1
reach
"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
Diarsenic trioxide affects EIF3F
1
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Cupric oxide affects EIF3F
1
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Core eIF3 complex affects EIF3F
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1
Copper(II) sulfate affects EIF3F
1
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Cobalt dichloride affects EIF3F
1
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Clothianidin affects EIF3F
1
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Chloropicrin affects EIF3F
1
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Bisphenol A affects EIF3F
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1
Bisphenol A activates EIF3F. 1 / 1
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1
Benzo[a]pyrene affects EIF3F
1
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Benzo[a]pyrene diol epoxide I affects EIF3F
1
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Alpha-chain affects EIF3F
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1
Aflatoxin B1 affects EIF3F
1
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reach
"The reduced Akt1 kinase activity observed upon statins treatment, resulted in an increase in dephosphorylation on FoxO3 and FoxO1 transcription factors, their translocation into the nucleus, and activation of the Atrogin1 and MAFbx gene encoding ubiquitin ligase E3, which eliminates MyoD, calcineurin, eIF3-F translation initiator, and FoxO1 [XREF_BIBR]."
sparser
"Five of these proteins have known or putative ATP binding domains (UBA1, HSP90AA1, HSPA2, RUVBL2 and ATP5B/ATP5A1), which is in accord with quercetin's known ability to inhibit ATPases and kinases. xref The remaining proteins, SF3B3 and EIF3F are not associated with nucleotide binding domains, and may bind to quercetin through some other site."
RP23-244N6.4 affects EIF3F
1
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RP23-151A15.2 affects EIF3F
1
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RP23-12I13.1 affects EIF3F
1
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Pool 1 affects EIF3F
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1
Niclosamide affects EIF3F
1
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NP_789740 affects EIF3F
1
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NP_705926 affects EIF3F
1
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Mechanical overload affects EIF3F
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1
MAFbx Atrogin-1 affects EIF3F
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1
L-methionine affects EIF3F
1
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ICP27 of HSV affects EIF3F
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1
HIV1gp5 affects EIF3F
1
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HIV1gp1 affects EIF3F
1
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sparser
"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
EIF3F affects tumor-free survival
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1
EIF3F affects translational phase cells synchronized nocodazole treatment
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1
EIF3F affects translational initiation
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1
EIF3F inhibits translational initiation. 1 / 1
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1
EIF3F affects specific robust recruitment endogenous eIF4G raptor rpS6 m7-GTP cap complex
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1
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1
eidos
"It is important to note that eIF3f induces a specific and robust recruitment of endogenous eIF4G , raptor and rpS6 to the m7-GTP cap complex , suggesting that this protein is not only an activator of the cap-dependent translation but also a major actor of the proper assembly of the translation initiation complex in myotubes ( Csibi et al ., 2010 ) ."
EIF3F affects snail2
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1
EIF3F affects skeletal muscle atrophy
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1
EIF3F inhibits skeletal muscle atrophy. 1 / 1
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1
EIF3F affects raptor-mTOR
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1
EIF3F affects rRNA
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1
EIF3F affects protein
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1
reach
"Notably, VPg of caliciviruses binds to eIF3, spike protein of severe acute respiratory syndrome coronavirus (SARS-CoV) and infectious bronchitis virus (IBV) binds to eIF3F, and matrix protein of rabies virus interacts with eIF3 complex and, in all cases, the binding facilitates viral mRNA translation and/or inhibits host cell translation."
EIF3F affects protein 1
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1
sparser
"Except for the directly connected and stress-related GTP-binding nuclear protein (RAN1; Jiang et al., xref ), other connections including 17 ribosomal proteins [e.g., 60S ribosomal protein L14-2 (RPL14B), 40S ribosomal protein S15-1 (RPS15) and 40S ribosomal protein S15-4 (RPS15D)], and actin-11 (ACT11), ADP/ATP carrier protein 1 (AAC1) and eukaryotic translation initiation factor 3 subunit F (TIF3F1) formed tertiary nodes."
EIF3F affects phosphorylated Akt PCa cells
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1
EIF3F affects p70S6k
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1
EIF3F affects molecular mechanisms cancer cell migration invasion
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1
EIF3F affects modification
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1
EIF3F affects models
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1
EIF3F affects migratory lung cancer cells
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1
sparser
"RHEB (Ras homolog enriched in brain) activates mTORC1 (mechanistic/mammalian target of rapamycin complex 1), which binds to the scaffold protein eIF3f (eukaryotic initiation factor 3f ) through a TOS (TOR signaling) motif and modulates mRNA translation by phosphorylating eIF3f bound-S6K1 (S6 kinase 1) and 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1)."
| PMC
EIF3F affects mTOR-raptor
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1
EIF3F affects luciferase reporter gene
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1
EIF3F affects heterogenous nuclear ribonucleoprotein K
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1
EIF3F affects hGle1
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1
EIF3F affects hCG1
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1
EIF3F affects formation
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1
EIF3F affects efficient protein synthesis
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1
EIF3F affects eIF3f proteasomal
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1
EIF3F affects eIF3 protein complex
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1
EIF3F affects eIF3 core
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1
reach
"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
EIF3F affects delayed tumor onset
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1
EIF3F affects core eIF3 complex
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1
EIF3F affects cell migration
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1
EIF3F activates cell migration. 1 / 1
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1
EIF3F affects cell metastasis
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1
EIF3F affects cell differentiation
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1
EIF3F inhibits cell differentiation. 1 / 1
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1
EIF3F affects cap-dependent translation
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1
EIF3F affects cap-dependent cap-independent translation
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1
EIF3F affects cap-dependent cap-independent i.e IRES mechanisms translation initiation
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1
EIF3F affects cancer cells
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1
EIF3F affects binding
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1
EIF3F affects binding hnRNP K rRNA
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1
EIF3F affects atrophy
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1
EIF3F affects anti-atrophic myotubes miRNA mimics
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1
EIF3F affects alpha-chain
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1
EIF3F affects adult skeletal muscle
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1
EIF3F affects activity
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1
EIF3F affects activation
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1
EIF3F affects Translation
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1
sparser
"Five of these proteins have known or putative ATP binding domains (UBA1, HSP90AA1, HSPA2, RUVBL2 and ATP5B/ATP5A1), which is in accord with quercetin's known ability to inhibit ATPases and kinases. xref The remaining proteins, SF3B3 and EIF3F are not associated with nucleotide binding domains, and may bind to quercetin through some other site."
EIF3F affects RP23-244N6.4
1
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EIF3F affects RP23-151A15.2
1
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EIF3F affects RP23-12I13.1
1
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EIF3F affects Prostatic Neoplasms
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1
EIF3F activates Prostatic Neoplasms. 1 / 1
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1
EIF3F affects Phosphorylation Akt
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1
EIF3F affects PI3K/Akt/mTOR
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1
EIF3F affects PI3K Akt mTOR
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1
EIF3F affects PCa cell
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1
EIF3F affects PCa cell growth vivo.Knockdown eIF3f
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1
EIF3F affects NP_789740
1
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EIF3F affects NP_705926
1
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EIF3F affects ICP27 of HSV
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1
EIF3F affects HIV1gp5
1
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EIF3F affects HIV1gp1
1
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EIF3F affects HIV replication
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1
EIF3F affects Growth PCa
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1
eidos
"EIF3f Knockdown Suppressed the Growth of PCa Tumor Xenografts To explore the function of eIF3f in the growth of PCa cells in vivo , we subcutaneously injected 22Rv1 cells stably expressing shRNA targeting eIF3f ( sheIF3f # 1 and sheIF3f # 2 ) or vector control ( shCON ) into 6-week-old nude mice ."
EIF3F affects Embryonic Development
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1
EIF3F activates Embryonic Development. 1 / 1
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1
EIF3F affects Cell Survival
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1
EIF3F inhibits Cell Survival. 1 / 1
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1
sparser
"Importantly, while no significant changes were observed in the relative levels of either the 52 or 47kDa forms of cathepsin D ( xref ), the reduction in levels of mature cathepsin D approached significance at 34kDa ( xref ) and was significant at 28kDa when compared against CTRL fibroblasts ( xref )."
EIF3F affects CDK11-9G8
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1
EIF3F affects Apoptosis
1
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EIF3F affects 1-phenylethanol
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1
EIF3F activates 1-phenylethanol. 1 / 1
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1
EIF3F affects (S) protein
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1
sparser
"The most interesting observation is that all these genes are associated with liver diseases: EIF3A, EIF3B, EIF3C, EIF3D and EIF3G are all associated with Liver Failure xref , Acute Hepatitis; EIF3E, EIF3F and EIF3K are associated with Liver Neoplasms xref ; EIF3H is associated with Carcinoma Hepatocellular xref ; EIF3I is associated with clonorchiasis xref ."
sparser
"Importantly, while no significant changes were observed in the relative levels of either the 52 or 47kDa forms of cathepsin D ( xref ), the reduction in levels of mature cathepsin D approached significance at 34kDa ( xref ) and was significant at 28kDa when compared against CTRL fibroblasts ( xref )."
COP9 signalosome subunits affects EIF3F
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1
CDK11-9G8 affects EIF3F
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1
Antirheumatic Agents affects EIF3F
1
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1
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17alpha-ethynylestradiol affects EIF3F
1
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(S) protein affects EIF3F
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1
(-)-epigallocatechin 3-gallate affects EIF3F
1
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3,3',4,4',5-pentachlorobiphenyl affects EIF3F
1
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