IndraLab

Statements

USP8 affects STAMBP
1 | 3 15
STAMBP binds USP8. 8 / 8
| 3 5
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156
sparser
"The interaction of the two endosomal DUBs, AMSH, and USP8 (UBPY in yeast), with a UIM-containing signal transducing adaptor molecule 2 (STAM2) enhances their deubiquitinating efficacy via substrate arrest [ xref , xref ]."
32512887
sparser
"Both AMSH and Usp8 bind components of the endosomal sorting complex for transport (ESCRT) which are involved in targeting ubiquitinated cargo receptors for incorporation into intraluminal vesicles (IL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and –III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
reach
"The DUBs AMSH (associated molecule with the SH3 domain of STAM) XREF_BIBR and UBPY (ubiquitin isopeptidase Y/ubiquitin specific protease 8) XREF_BIBR, bind both the ESCRT-0 component STAM (signal transducing adaptor molecule) and ESCRT and III complex members XREF_BIBR, and are implicated in regulating EGFR sorting onto the degradative pathway."
24295852
reach
"The competitive binding of AMSH and USP8 to ESCRT subunits, and the fact that they associate with both ESCRT-0 and -III, suggests that these DUBs may regulate cargo deubiquitination in complex ways."
21332354
sparser
"AMSH and Usp8 bind with their PxxP motif to the non-canonical SH3-binding motif of ESCRT-0 protein STAM, and with their MIT (Microtubule Interacting and Transport)-domain to several CHMP proteins of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23333852
sparser
"AMSH and USP8 can also interact with CHMP proteins that are components of the late ESCRT-III machinery xref , xref ."
26918171
STAMBP binds USP8 and STAM. 5 / 5
| 5
sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
26918171
USP8 binds STAMBP and CHMP1B. 1 / 1
1 |
hprd
No evidence text available
17711858
USP8 binds STAMBP, STAM, and HRS. 1 / 1
| 1
sparser
"Ubiquitylation is a highly dynamic process, and Ub is ultimately removed from cargoes prior to MVB vesicle incorporation by the deubiquitylating ESCRT enzymes, UBPY or AMSH, which interact with both the HRS:STAM adaptor and ESCRT-III subunits ( xref , xref )."
23527693
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
USP8 binds STAMBP and AVP. 1 / 1
| 1
sparser
"Like Doa4 in yeast, mammalian Usp8 and AMSH associate with class E Vps proteins on endosomes."
19489724
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP4B binds STAMBP, MITD1, and USP8. 1 / 1
| 1
sparser
"To test this idea, we assayed whether the CHMP4C peptide could competitively inhibit AMSH, MITD1 and USP8 MIT binding to labeled CHMP4B ( xref )."
36107470
CHMP4A affects CHMP4B, MITD1, RAD51B, STAMBP, USP8, and chmp4
| 1
Chmp4 binds RAD51B, CHMP4A, CHMP4B, MITD1, USP8, and STAMBP. 1 / 1
| 1
sparser
"This was surprising, particularly as MITD1, USP8, and AMSH all bound the other two CHMP4 paralogs, CHMP4A and CHMP4B ( xref )."
36107470
CHMP3 affects USP8
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
CHMP1B affects USP8
1 |
USP8 binds STAMBP and CHMP1B. 1 / 1
1 |
hprd
No evidence text available
17711858
CHMP1A affects USP8
| 1
CHMP1A binds CHMP2A, CHMP3, STAMBP, and USP8. 1 / 1
| 1
sparser
"CHMP1 (Did2), CHMP2 (Vps2) and CHMP3 (Vps24) can interact with two mammalian deubiquitinating enzymes, AMSH and UBPY, to facilitate their recruitment directly [ xref , xref , xref ]."
19143619
AVP affects USP8
| 1
USP8 binds STAMBP and AVP. 1 / 1
| 1
sparser
"Like Doa4 in yeast, mammalian Usp8 and AMSH associate with class E Vps proteins on endosomes."
19489724