IndraLab

Statements

TSC2 affects TSC1
7 16 2 37 13 | 3 2140 888 7
TSC1 binds TSC2. 10 / 2949
7 15 2 37 12 | 3 2122 724 7
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"Hamartin and tuberin associate in viva and patients with alterations in either gene show identi- cal symptoms [50’,51]."
10449328
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"XREF_BIBR Accumulation of the TSC1 and TSC2 complex is achieved through competitive inhibition of complex formations between 14-3-3 and TSC2 by DNA-damage-inducible transcript 4 (DDIT4 or REDD1)."
21272156
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"TSC2 and TSC1 can form a dimer and inhibit the GTPase activity of Rheb, a critical activator of mTOR signaling XREF_BIBR."
25210493
bel
"In turn, Akt phosphorylates the tuberous scleorisis complex, TSC1/TSC2 (hamartin/tuberin) that serves as a GTPase activating protein (GAP) for the small G protein, Ras homolog enriched in brain (Rheb)."
16404421
sparser
"Interestingly, crosstalk between PI3K/Akt/mTOR pathways and MAPK pathways has been investigated that elevated ERK negatively affects mTOR phosphorylation through TSC1-TSC2 complex and Rheb [ xref ]."
32120831
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"However, mTORC2 activation requires PI3K and the TSC1 and TSC2 complex, but is independent of Rheb and is largely insensitive to either nutrients or energy conditions [XREF_BIBR]."
20671809
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"We find that mTORC2 isolated from a variety of cells lacking a functional TSC1 and TSC2 complex is impaired in its kinase activity toward Akt."
18411301
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"TSC1 and TSC2 form a heterodimeric complex that can regulate protein synthesis by controlling mTORC1 activity."
25351249
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"These results suggest that FIP200 interaction with the TSC1 and TSC2 complex might not be required for FIP200 regulation of cell cycle progression."
16043512
reach
"Akt and PKB both regulates and is regulated by the TSC1 and TSC2 complex."
19143635
TSC1 binds TSC2 and TBC1D7. 10 / 32
1 | 10 21
sparser
"The overall architecture of TSC1–TSC2 and TSC1–TBC1D7 interactions together allows one TBC1D7 to be assembled into TSC complex and this subunit stoichiometry is consistent with previous structural and biochemical analyses xref , xref ."
33436626
reach
"Our work gives more detailed insight into the structural and functional relationships between TSC1 and TBC1D7, and provides useful information for further studies aimed at unravelling the molecular structure of the TSC1, TSC2, and TBC1D7 complex."
24714658
reach
"The TSC1, TSC2, and TBC1D7 complex is an important negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues."
24714658
sparser
"When the TSC1-TSC2-TBC1D7 (TSC-TBC) complex is formed, it inhibits mTORC1 activity by means of its GTPase-activating protein (GAP) domain [ xref , xref ]."
26937223
sparser
"Active AKT decreases interaction between PRAS40 and mTORC1 and deactivates the tuberous sclerosis complex (TSC) formed by TSC1, TSC2 and TBC1D7 [ xref ]."
25592035
sparser
"This suggests that the TSC1-TSC2-TBC1D7 interaction may also be conserved."
24714658
reach
"TSC1 is an essential component of the TSC1, TSC2, and TBC1D7 complex."
24714658
sparser
"The TSC complex, formed by the subunits TSC1, TSC2, and TBC1D7, is responsible for relaying most growth factor signaling pathways to mTORC1 (Ben‐Sahra & Manning, xref )."
29210103
sparser
"Additional immunoprecipitations with antibodies that only recognize TSC2 phosphorylated by Akt on either S939 or T1462, confirmed that TSC1 and TBC1D7 readily associate with phosphorylated TSC2 and remain stably bound even after an hour of insulin stimulation ( xref )."
24529379
sparser
"TSC2 forms a protein complex with TSC1 and the recently discovered protein TBC1D7 [ xref ]."
26937223
TSC1 binds TSC2 and RB1CC1. 10 / 23
1 | 22
sparser
"We found that association of FIP200 or its segments N1-859 and N1-638 with the TSC1–TSC2 complex correlated with their ability to increase cell size, up-regulate S6K phosphorylation, and decrease TSC1–TSC complex formation."
16043512
sparser
"These results suggest that FIP200 interaction with the TSC1–TSC2 complex might not be required for FIP200 regulation of cell cycle progression."
16043512
sparser
"Together, these studies suggest that FIP200 interaction with the TSC1–TSC2 complex inhibits its function in the negative regulation of S6K activation through mTOR, which is responsible for the regulation of cell size control by FIP200."
16043512
sparser
"Thus, the identification of the interaction between FIP200 and the TSC1–TSC2 complex raises the possibility that this interaction may play a role in the regulation of cell cycle progression by FIP200."
16043512
sparser
"Similar studies indicated that the N1-859 segment of FIP200, but not the N1-638 segment, which does not bind to TSC1–TSC2, also increased the average cell size of the transfected 293T cells ( xref )."
16043512
sparser
"FIP200 interaction with the TSC1–TSC2 complex is not involved in FIP200 regulation of cell cycle progression."
16043512
sparser
"Therefore, we examined the possible effect of FIP200 on TSC1–TSC2 complex–mediated inhibition of S6K to determine the mechanisms by which FIP200 interaction with the TSC1–TSC2 complex regulated cell size."
16043512
sparser
"We found that association of FIP200 with the TSC1–TSC2 complex correlated with its ability to increase cell size and up-regulate S6 kinase phosphorylation but was not involved in the regulation of cell cycle progression."
16043512
sparser
"Here, we report identification of FIP200 interaction with the TSC1–TSC2 complex and show that this interaction leads to inhibition of TSC1–TSC2 complex function resulting in increased S6K activity and cell growth."
16043512
sparser
"We initially hypothesized that the interaction between FIP200 and the TSC1–TSC2 complex would play a role in FIP200-mediated cell cycle progression."
16043512
TSC1 binds TSC2 and MTOR. 10 / 13
| 13
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"Interaction of hamartin with tuberin forms a heterodimer that inhibits signaling by the mammalian target of rapamycin to its downstream targets: eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1)."
12867426
sparser
"These results suggest that the identified TSC1 and TSC2 mutations are closely associated with both aberrant mTOR activation and dysregulation of neuronal growth in individuals with FCDII."
28215400
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"Hamartin and tuberin proteins form a complex which would further downregulate the activity of mammalian target of rapamycin (mTOR) activity."
33897168
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"This is achieved via directly phosphorylation of Ser 1345 and Thr 1227 on the tumour suppressor protein tuberous sclerosis 2 (TSC2), which forms an mTOR complex 1 (mTORC1)-inhibitory complex with TSC1 [ xref ]."
26475449
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"The genes code for the proteins hamartin (TSC1) and tuberin (TSC2) which form a complex that regulates the mTOR cell signalling pathway, responsible for important aspects of cell growth and differentiation [ xref ]."
28270230
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"However, due to the limitations of this method, it does not allow us to conclude in which part of the GA, (i.e., cis-, medial-, or trans-) mTOR and TSC1-TSC2 complex exert their effects on cargo transport."
34006213
sparser
"Here we explored the hypothesis that mutations in MTOR , TSC1 or TSC2 are associated with response to rapalog therapy."
26831717
sparser
"Mutations of either tuberous sclerosis 1 (TSC1) or TSC2 are associated with aberrant activation of mammalian target of rapamycin (mTOR) pathway, which increases the risk of RCC ( xref , xref )."
27347102
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"In addition, TSC1 and TSC2 , which form a complex that negatively regulates mTOR activity, demonstrate decreased mRNA and protein levels in GBMs compared to grade II tumors and non-tumor brain."
18759130
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"TSC1 and TSC2 gene products—hamartin and tuberin, respectively—are components of a complex that negatively regulates mTOR signaling and, correspondingly, inactivation of TSC1 or TSC2 is associated wit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15261145
TSC binds TSC1 and TSC2. 10 / 10
| 10
sparser
"In mouse models of TSC, loss of Tsc1 or Tsc2 is associated with abnormal neuronal connectivity – specifically neuronal polarity, axon formation and guidance [ xref – xref ]."
24489482
sparser
"In addition, the TSC complex, which is formed by TSC1 and TSC2, can activate mTORC2 in an independent Rheb manner [ xref ]."
32824627
sparser
"TSC gene products TSC1 and TSC2 form a functional complex and inhibit cell growth."
18926585
sparser
"Hence, loss of the TSC protein complex, either TSC1 or TSC2, leads to high levels of RHEB-GTP, and constitutive activation of mTORC1 [ xref ]."
33891611
sparser
"Two tumor suppressor genes, TSC1 and TSC2 , are associated with the development of TSC, and mutations in either gene are responsible for both the familial and sporadic forms of TSC ( Young and Pove[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17693255
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"The two genes associated with TSC, TSC1 and TSC2 , were discovered by linkage analysis of large TSC families conducted by multinational consortia in 1997 and 1993, respectively."
28099079
sparser
"TSC1 and TSC2 together form the upstream negative regulator TSC complex for mTORC1."
32849516
sparser
"Activated AKT inhibits the formation of the tuberous sclerosis proteins TSC1 and TSC2, thus allowing activation of MTOR."
24882635
sparser
"TSC is associated with mutations in 2 genes, TSC1 and TSC2, which encode hamartin and tuberin, respectively."
11444800
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"The overactivated mammalian target of rapamycin (mTOR) complex 1 (mTORC1) in TSC is associated with loss of function mutation in TSC1 and TSC2 genes ( xref , xref )."
28427564
GAP binds TSC1 and TSC2. 6 / 6
| 6
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"The C-terminal domain of TSC2 contains a small region of homology with GTPase-activating proteins (GAPs), and TSC1 and TSC2 interact to form a complex that acts as a GAP for the small G-protein RHEB, accelerating the conversion of RHEB from its active GTP-bound state to its inactive GDP-bound form xref ."
24714658
sparser
"Hamartin and tuberin are encoded by TSC1 and TSC2 which form a GTPase activating protein heteromer that inhibits the Rheb GTPase from activating a growth promoting protein kinase called mammalian target of rapamycin (mTOR)."
36277492
sparser
"This is accomplished by AKT-1 phosphorylation and inactivation of TSC2 [ xref - xref ], which forms a TSC1–TSC2 protein complex that is a GAP for the RHEB G-protein."
22983298
sparser
"The TSC1 and TSC2 genes encode Hamartin and Tuberin which form a GTPase activating protein (GAP) complex."
32765227
sparser
"The regulation of mTORC1 is dependent on tuberous sclerosis 1 and 2 proteins (TSC1 and TSC2), which form a stable heterodimer (TSC1:TSC2 complex), of which the TSC2 subunit acts as a GTPase-activating protein for the small GTPase Rheb, which negatively controls Rheb and activates mTOR [ xref , xref ]."
32010489
sparser
"The TSC1 and TSC2 genes encode for the proteins hamartin and tuberin that form a GTPase activating protein (GAP) complex and inhibit RAS homologue enriched in brain (RHEB; Garami et al., xref ; Inoki et al., xref ; Tee et al., xref ; Zhang et al., xref )."
32765227
TSC1 binds TSC1, TSC2, and TSC2. 5 / 5
| 5
sparser
"It is also possible that TSC1 facilitates the formation of TSC1-TSC2 complexes containing multiple TSC1 and TSC2 subunits."
23006675
sparser
"Therefore, it is unlikely that the detected TSC1–TSC1 interactions are a consequence of the formation of TSC1–TSC2 complexes containing multiple TSC1 and TSC2 subunits."
20547222
sparser
"TSC is a dominantly inherited multisystem disorder characterized by the formation of hamartomas in different organs and the brain, caused by mutations in the TSC1 or TSC2 genes encoding hamartin and tuberin, respectively."
30705255
sparser
"TSC1 and TSC2 interact to form large complexes containing multiple TSC1 and TSC2 subunits."
23006675
sparser
"Hamartin and tuberin, the TSC1 and TSC2 gene products, interact and the tuberin-hamartin complex inhibits cell growth by antagonising signal transduction to downstream effectors of the mammalian target of rapamycin (mTOR) through the small GTPase rheb."
15483652
MTORC2 binds TSC1 and TSC2. 5 / 5
| 5
sparser
"Most surprising was the finding that the TSC1-TSC2 complex can physically associate with components of mTORC2, but not those unique to mTORC1."
19602587
sparser
"In a previous study, we found that the TSC1-TSC2 complex can physically associate with mTORC2, but not mTORC1, and that the mTORC2 associated with the TSC1-TSC2 complex was catalytically active ( xref )."
19602587
sparser
"The N-terminal region of TSC2 and C-terminal region of Rictor mediate the interaction between the TSC1-TSC2 complex and mTORC2."
19602587
sparser
"To avoid co-purification of endogenous mTORC2, we washed the immunoprecipitates with a high salt wash buffer found previously to disrupt binding of mTORC2 to the TSC1-TSC2 complex ( xref )."
19602587
sparser
"Finally, we find that the TSC1-TSC2 complex can physically associate with mTORC2 but not mTORC1."
18411301
MTORC1 binds TSC1 and TSC2. 5 / 5
| 5
sparser
"While in our experiments relatively acute mTORC1 activation (< 24 hrs) did not alter postsynaptic function directly, there is evidence to suggest that longer, chronic hyperactivation of neuronal mTORC1, via knockdown of TSC1 or TSC2, is associated with morphological and functional changes in the postsynaptic compartment ( xref ; xref )."
23197706
sparser
"In the unstimulated condition, TSC1 forms a complex with TSC2, inhibiting mTORC1 [ xref , xref , xref – xref ]."
29416749
sparser
"Likewise, inactivating mutations in the TSC1 or TSC2 genes cause hamartoma syndromes associated with elevated mTORC1 activity ( xref , xref )."
21216931
sparser
"PKB, by inhibiting the mTORC1 negative regulator tuberous sclerosis complex (TSC), a heterodimer composed by TSC1 and TSC2, finally activates mTORC1 [ xref , xref ]."
33348908
sparser
"The TSC1 and TSC2 proteins form a complex that negatively regulates the mTORC1 signaling pathway, a central signaling hub controlling cellular metabolic processes such as protein and lipid synthesis and autophagy ( xref )."
34380034
AMPK binds TSC1 and TSC2. 4 / 4
| 4
sparser
"In the present study, the activation of AMPK by Met in DLD1 cells with mutated KRAS resulted in an increase in the interaction between TSC2, TSC1, and AMPK (Fig. xref f)."
| PMC
sparser
"Sestrin 1 and 2 have been shown to interact with AMPK, TSC1, and TSC2 to inhibit mTOR signaling in response to genotoxic stress xref ."
27935061
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"For instance, SESN2 (up-regulated by ~ 3.1-fold) which is stress inducible and regulated by p53 inhibits mTORC1 by activating AMPK via forming AMPK-TSC1:TSC2 complex xref – xref ."
33452321
sparser
"Co-immunoprecipitation and gel filtration analyses revealed an interaction between Sesn2 and AMPKα, suggesting that Sestrins are engaged in formation of a large protein complex containing AMPK and TSC1:TSC2."
18692468
P14_3_3 binds TSC1 and TSC2. 3 / 3
| 3
sparser
"The binding of the 14-3-3 protein to the TSC1-TSC2 complex prevents an inhibition of S6 kinase and the non-phosphorylation of 4E binding protein 1, i.e., it causes a weakening of the PI3K/PKB/TOR pathway signaling [ xref ]."
28125008
sparser
"We suggest that 14-3-3 proteins interact with the TSC1-TSC2 complex and negatively regulate the function of the TSC proteins."
12468542
sparser
"Detection of a ternary complex of tuberin, hamartin and 14-3-3 suggests that the tuberin-14-3-3 interaction is compatible with tuberin-hamartin binding and that 14-3-3 proteins interact with the tuberin-hamartin complex [ xref , xref ]."
19506736
TSC1 binds TSC2 and SESN2. 3 / 3
| 3
sparser
"None of these proteins was precipitated by the Flag antibody if they were co-expressed with GFP instead of Sesn2F. Reciprocal immunoprecipitation experiments confirmed the interaction of Sesn2 with TSC1, TSC2 and AMPKα2 ( xref )."
18692468
sparser
"Upregulated Sesn2 interacted with TSC1:TSC2 and AMPKα for activating AMPKα phosphorylation, which led to the inhibition of mTROC1 signaling ( xref )."
34867324
sparser
"None of these proteins was precipitated by the Flag antibody if they were coexpressed with GFP instead of Sesn2F. Reciprocal immunoprecipitation experiments confirmed the interaction of Sesn2 with TSC[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18692468
TSC binds TSC1, TSC2, and TBC1D7. 3 / 3
| 3
sparser
"TSC1, TSC2, and TBC1D7 assemble the TSC complex with a 2:2:1 stoichiometry, generating an asymmetric modular organization."
33436626
sparser
"This interaction is inhibited by the Rheb-GTPase activating protein (GAP) activity of the tuberous sclerosis protein complex (TSC) that is formed by the TSC1, TSC2 and TBC1D7 proteins [ xref ]."
25950843
sparser
"The TSC heteromeric complex formed by TSC1, TSC2 and TBC1D7 acts as a GTPase activating protein (GAP) for the small Ras-related GTPase Rheb, which, in active GTP-bound form, binds and activates mTOR."
31258848
TSC1 binds TSC2 and NR4A1. 3 / 3
| 3
sparser
"The reciprocal precipitation also demonstrated that TR3 was associated with TSC1 and TSC2 (Supporting Information xref )."
23197407
sparser
"TSC1 and TSC2 both bound to the ligand-binding domain (LBD) of TR3 (Supporting Information xref )."
23197407
sparser
"TR3 bound to TSC2-TSC1 dimers and induced TSC2 ubiquitination and degradation, which led to the activation of mTORC1 but not mTORC2."
23197407
TSC1 binds TSC2, PEX19, and PEX5. 3 / 3
| 3
sparser
"We found TSC1 and TSC2 bound to PEX19 and PEX5, respectively, and an ARL sequence required for PEX5 binding and localization to peroxisomal membranes was identified."
23955302
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"TSC1 and TSC2 bind peroxins PEX19 and PEX5."
23955302
sparser
"TSC1 and TSC2 were bound by PEX19 and PEX5, respectively, and peroxisome-localized TSC functioned as a Rheb GAP to suppress mTORC1 and induce autophagy."
23955302
RHEB binds TSC1 and TSC2. 3 / 3
| 3
sparser
"However, Akt-mediated phosphorylation inhibits the formation of the TSC1-TSC2 complex causing the accumulation of GTP-bound Rheb."
32708855
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"TSC2 forms a complex with TSC1 to promote GTP hydrolysis by the small GTPase Rheb."
20478529
sparser
"Growth factor signals and energy status are transmitted to mTOR C1 via TSC a complex of TSC1 and TSC2 proteins, which bind to Rheb and inhibit mTOR C1 activation."
19725049
sparser
"To determine whether the Sestrins can interact with TSC1, TSC2 or AMPK, we expressed TSC1-Myc, TSC2-HA and AMPKα2-Myc together with Sesn2F in HEK293 cells."
18692468
sparser
"Sestrins interact with TSC1, TSC2 and AMPK."
18692468
AMPK binds TSC1, TSC2, and MTOR. 2 / 2
| 2
sparser
"The complex of hamartin (TSC1) and tuberin (TSC2) interact with AMPK and mTOR, and mutations in TSC1 or TSC2 lead to uncontrolled cell growth. xref TSC is associated with characteristic neoplasms such as neurofibromas in the skin, angiomyolipoma in the kidney and LAM in the lung."
23223565
sparser
"Sestrins inhibit mTORC1 activity by interacting with mTOR pathway suppressors AMPK, TSC1, and TSC2 [ xref ]."
22829831
sparser
"Mutations in TSC1 or TSC2 gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by the formation of non-malignant hamartomas in multiple vital organs."
31655562
sparser
"Inactivating mutations in either TSC1 or TSC2 cause Tuberous Sclerosis Complex, an autosomal dominant disorder, characterized by multi-system tumor and hamartoma development."
33891611
GAP binds RHEB, TSC1, and TSC2. 2 / 2
| 2
sparser
"TBC1D7 knockdown using siRNA decreased the association of TSC1 and TSC2 resulting in the decrease of Rheb-GAP activity."
24863881
sparser
"TBC1D7 knockdown decreases the association of TSC1 and TSC2 leading to decreased Rheb-GAP activity, without effects on the localization of TSC2 to the lysosome."
22795129
GAP binds mTORC1, RHEB, TSC1, and TSC2. 2 / 2
| 2
sparser
"Most of these signals exert their effect on mTORC1 by modulating the activity of the tuberous sclerosis complex proteins, TSC1 and TSC2, which form a heterodimer that functions as a GTPase activating protein (GAP) to inhibit the activity of the small GTPase Rheb ( xref )."
18762019
sparser
"Most of these signals exert their effect on mTORC1 by modulating the activity of the tuberous sclerosis complex proteins, TSC1 and TSC2, which form a heterodimer that functions as a GTPase activating [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18762019
RHEB binds TSC1, TSC2, and MTOR. 2 / 2
| 2
sparser
"Most TSC patients present with mutations in the TSC1 or TSC2 genes, which encode proteins that form the TSC1-TSC2 complex that serves to antagonize the signaling pathway downstream of mammalian target of rapamycin (mTOR) by promoting the activation of the small GTPase Rheb and thereby inhibiting cellular growth and proliferation."
34901059
sparser
"Full-length TSC2 protein interacts with TSC1 to inhibit the activation of mTOR by Rheb."
24318044
AKT binds TSC1 and TSC2. 2 / 2
| 2
sparser
"AKT associates with TSC1-TSC2 complexes, promoting phosphorylation of TSC2, and increases degradation of TSC1-TSC2 complexes [ xref ]."
26318033
sparser
"Inoki et al. observed a weakened interaction between Akt-phosphorylated TSC2 and TSC1 in mammalian cells, which lead to ubiquitin-mediated degradation of TSC2 ( xref )."
20965424
TSC1 binds TSC2 and tumour suppressor. 2 / 2
| 2
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"This disorder is caused by mutations in TSC1 or TSC2 that encode tumour suppressor proteins which form the complex TSC1–TSC2 that regulate protein synthesis in a wide range of mammalian cell types, including neurons xref ."
23325215
sparser
"TSC2 protein forms a heterodimeric tumour suppressor complex with TSC1, which is at the crossroads of many different signalling pathways, and serves as a nexus for integrating extracellular growth factor signalling and nutritional availability [ xref , xref ]."
24318044
TSC1 binds TSC2 and TOR. 2 / 2
| 2
sparser
"We show that Tsc1 and Tsc2 can physically associate with TOR and function upstream of TOR genetically."
12172555
sparser
"One possibility is that TOR and TSC1-TSC2 complexes associate with detergent-containing micelles."
23006675
TSC1 binds TSC2 and catenin. 1 / 1
| 1
sparser
"It is interesting to note that the tumor suppressor complex formed by TSC1 and TSC2 interacts with the β -catenin degradation complex and thus modulates the action of Wnt signaling [ xref , xref ]."
26881141
TSC1 binds TSC2, RB1CC1, and MEF. 1 / 1
| 1
sparser
"Together, these results demonstrate that FIP200 could associate with the TSC1–TSC2 complex in mammalian cells such as 293T cells and MEFs."
16043512
MTORC1 binds TSC1, TSC2, and NCAPD2. 1 / 1
| 1
sparser
"The finding of the association of mTORC1 with the bipartite complex TSC1 and TSC2 of tumor suppressor proteins provided a molecular link between mTOR and cancer (reviewed in REF xref )."
19644473
TSC1 binds TSC2 and TRIM6. 1 / 1
| 1
sparser
"Moreover, the results of the Co-IP and immunofluorescence staining both indicated that TRIM6 was tightly associated with TSC1 and TSC2 ( xref )."
33634104
Mutated TSC1 binds TSC2. 1 / 1
| 1
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"Inactivating mutations of the TSC1 and TSC2 complex (TSC1/2) cause tuberous sclerosis (TSC), a hereditary syndrome with neurological symptoms and benign hamartoma tumours in the brain."
27516388
TSC1 binds TSC2 and GAP domain. 1 / 1
| 1
reach
"TSC1 is required to stabilize TSC2 as the TSC1 and TSC2 complex and the GAP domain on TSC2 hydrolyze Rheb-GTP to Rheb-GDP, thereby inhibiting the activation of mTOR kinase 42."
28215400
TSC1 binds TSC2 and ARSD. 1 / 1
| 1
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"ASD was not associated with TSC1 or TSC2 mutations ( P = 1.0)."
23445896
TSC1 binds TSC2, STRADA, and PTEN. 1 / 1
| 1
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"Among these, TSC1, TSC2, STRADα and PTEN are associated with epilepsy and autism in humans and animal models."
21890410
TSC1 binds TSC2 and PLK2. 1 / 1
| 1
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"We have demonstrated that Plk2 interacts with both TSC1 (endogenous, CT-Plk2) and TSC2 (CT-Plk2) in various cell types."
20054236
TSC1 binds TSC2 and D1. 1 / 1
| 1
reach
"It was suggested that TSC1 and TSC2 complex may regulate Cyclin D1 expression through canonical Wnt and beta-catenin signaling."
25639352
MTORC1 binds TSC1, TSC2, HERC1, and ATP6AP1. 1 / 1
| 1
sparser
"TSC subunit 1 (TSC1) stabilizes TSC2 by inhibiting the interaction between TSC2 and HERC1, forming a TSC1-TSC2 complex that negatively regulates mTORC1."
32921582
TSC1 binds TSC2 and RICTOR. 1 / 1
| 1
sparser
"However, when either mTOR or mSin1 were omitted, only Rictor bound to the TSC1-TSC2 complex, demonstrating that Rictor is sufficient for the association."
19602587
sparser
"Tuberous sclerosis complex is exclusively associated with mutations in either the TSC1 or TSC2 tumour suppressor gene, which encodes the proteins hamartin and tuberin, respectively."
23143994
AMPK binds TSC1, TSC2, and SESN2. 1 / 1
| 1
sparser
"To study whether a complex containing Sesn2, TSC1, TSC2 and AMPK can form under more physiological conditions, we immunoprecipitated lysates of MCF7-tet OFF Sesn2F or MCF7-tet OFF GFP cells with the Flag antibody."
18692468
ERK binds TSC1 and TSC2. 1 / 1
| 1
sparser
"As a result, upon abrogation of basal levels of Erk activity, wild-type TSC2 binds TSC1 as strongly as TSC2 S664A/S540A , suggesting that the observed stronger interaction between TSC1 and the TSC2 S6[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15851026
AMPK binds TP53, TSC1, TSC2, and MTOR. 1 / 1
| 1
sparser
"The antioxidant response of p53 also inhibits the mTOR pathway via the Sestrins, which are induced by p53 and can interact with mTOR pathway suppressors AMPK, TSC1 and TSC2 [ xref ]."
21340684
TSC1 binds TSC2 and Thr1462. 1 / 1
| 1
reach
"AKT is a key activator of the Mammalian target of rapamycin (mTOR) signaling cascade by directly phosphorylating Ser 2448 of mTOR and by inhibiting of the TSC1/TSC2 complex via catalyzing Thr1462 phosphorylation of TSC2."
33294746
TSC1 binds TSC2 and NTS. 1 / 1
| 1
sparser
"The T147K, M280T, and L369P substitutions are predicted to either cause a packing defect or disrupt helix formation of the TSC2 NT domain that is required for the interaction with TSC1 (Zech et al., xref )."
31799751
TSC binds TSC1, TSC1, TSC2, and TSC2. 1 / 1
| 1
sparser
"Genetically, TSC is associated with mutations in TSC1 or TSC2 (located on 9q 34 and 16q13 respectively), leading to impaired production of the proteins hamartin and tuberin respectively."
25750268
MTORC1 binds RHEB, TSC1, and TSC2. 1 / 1
| 1
sparser
"Loss-of-function TSC1 or TSC2 mutations are associated with increased Rheb-GTP levels and aberrant activation of mTORC1 in various TSC-associated hamartomas ( xref , xref )."
20498248
TSC1 binds TSC2 and ATXN3. 1 / 1
| 1
sparser
"PEComas are related to the genetic alterations of tuberous sclerosis complex (TSC), an autosomal dominant genetic disease associated with losses of TSC1 (9q34) or TSC2 (16p13.3) genes, which seem to have a role in the regulation of the Rheb/mTOR/p70S6K pathway."
24965209
TSC binds TSC1, TSC2, and MTOR. 1 / 1
| 1
sparser
"TSC is associated with mutations in TSC1 or TSC2, resulting in hyperactivation of mTOR complex 1 (mTORC1)."
28710231
TSC1 binds TSC2 and PIK3C3. 1 / 1
| 1
sparser
"Given that TSC1 is required for the stability of TSC2 [ xref ], we hypothesized that binding of VPS34 to TSC1 disengaged TSC1/TSC2 heterodimer, which may lead to degradation of TSC2."
27409169
TSC1 binds TSC1, TSC2, TSC2, and ATXN3. 1 / 1
| 1
sparser
"TSC is an autosomal dominant disease that is associated with gene mutations of TSC1 or TSC2 , encoding hamartin and tuberin, respectively [ xref ]."
23072249
TSC1 binds TSC2, PEX19, and Flag. 1 / 1
| 1
sparser
"While a very small amount of Flag-TSC2 was associated with the PEX19-TSC1 complex ( xref ), this association was abrogated with the TSC2-G294E mutant (a TSC1 binding-deficient mutant xref ), indicating the little TSC2 detected in this complex was likely associated with TSC1, rather than directly bound to PEX19 ( xref )."
23955302
TSC1 binds TSC2, CCNB1, MTOR, and Ribosomal Protein S6. 1 / 1
| 1
sparser
"This allows the formation of an active TSC1-TSC2 dimer that inhibits the phosphorylation of Ribosomal Protein S6 Kinase B1 (RPS6KB1) by the mTOR protein complex, which in turn inhibits the phosphorylation of Ribosomal Protein S6 (RPS6), part of the 40S ribosomal subunit required for initiation [ xref ]."
33477877
TSC1 binds TSC2, CIB2, RPTOR, and MTOR. 1 / 1
| 1
sparser
"To gain insights into the molecular mechanism of CIB2-mediated mTORC1 modulation, we assessed direct interactions between CIB2 and TSC1, TSC2, mTORC1-specific subunit Raptor, mTOR kinase, and Rheb, using a previously reported nanoscale pulldown 2.0 (NanoSPD) quantitative interaction assay xref ."
34162842
TSC1 binds TSC2 and PAM. 1 / 1
| 1
sparser
"Our studies show that Pam interacts with the TSC1-TSC2 complex, and regulates mTORC1 signaling [ xref , xref , xref ]."
23514105
VEGF binds TSC1 and TSC2. 1 / 1
| 1
sparser
"Loss of the TSC1 or TSC2 gene has been associated with increased production of vascular endothelial growth factor (VEGF), and inhibitors of mTOR have been shown to have an inhibitory effect on production of VEGF, tumor growth, and angiogenesis, both in vitro and in vivo. xref , xref "
24143074
TSC1 binds TSC2 and 293T. 1 / 1
| 1
reach
"Consistent with these transfection studies, we could also detect the interaction of endogenous FIP200 with the endogenous TSC1 and TSC2 complex in 293T cells (XREF_FIG E)."
16043512
TSC1 binds TSC2, MMP2, and PHEX. 1 / 1
| 1
sparser
"Here we show that TSC1 and TSC2 associate with PEX proteins and are localized to peroxisomal membranes, where they regulate mTORC1 signaling in response to ROS."
23955302
Phosphorylated TSC1 binds TSC2. 1 / 1
| 1
reach
"The phosphorylated TSC1 and TSC2 complex inactivates the Rheb GTP component needed for mTOR signaling."
19549896
TSC1 binds TSC2 and SIRT1. 1 / 1
| 1
sparser
"Our results demonstrate that SIRT1 and mTOR signaling pathways are indeed interconnected in a way that promotes stress sensing pro-survival signals, where the regulation of mTOR is mediated potentially through an interaction of SIRT1 with the TSC1-TSC2 complex."
20169165
TSC1 binds TSC2 and proline. 1 / 1
| 1
reach
"Perhaps the most dramatic metabolic consequence of PI3K and Akt stimulation however, is downstream activation of the cell growth regulator mechanistic target of rapamycin complex 1 (mTORC1) upon Akt mediated phosphorylation of either of two mTORC1 inhibitors : tuberous sclerosis 2 (TSC2; part of the TSC1 and TSC2 complex) or proline rich Akt substrate 40 kDa (PRAS40)."
23009760
AXIN binds Wnt, TSC1, TSC2, and CTNNB1. 1 / 1
| 1
sparser
"Both TSC1 and TSC2 are able to associate with Axin and β-catenin in the canonical Wnt pathway, and an absence of either TSC1 or TSC2 has shown to increase Wnt signaling ( Mak, Takemaru, Kenerson, Moon[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30086265
GST binds TSC1, TSC2, and TBC1D7. 1 / 1
| 1
sparser
"Furthermore, the pull-down analysis showed that both of TSC1 and TSC2 obtained from HEK293 cells bound to the bacterial GST-TBC7 in a dose-dependent manner, but not to the control protein (D)."
17658474
TP53 binds TSC1 and TSC2. 1 / 1
| 1
sparser
"Further application of full exome and genome sequencing will likely uncover additional evidence of genetic interactions between TP53 and both TSC1 and TSC2 in a variety of human cancers."
23580196
TGFB1 binds TSC1 and TSC2. 1 / 1
| 1
sparser
"Furthermore, we found that reduced expression of TSC1 and TSC2 caused by TGF-β1 is associated with the promoter methylation status of TSC1 and TSC2."
28041914
TSC1 binds TSC2 and TBC1 domain. 1 / 1
| 1
reach
"TSC2 forms a complex with TSC1 and TBC1 domain family member 7 (TSC complex) and acts as a negative regulator of mTORC1 signaling XREF_BIBR, XREF_BIBR, XREF_BIBR."
26918392
E3_Ub_ligase binds TSC1 and TSC2. 1 / 1
| 1
sparser
"Also it is suggested that TSC1 interacts with TSC2 to stabilize TSC2 by excluding HERC1 ubiquitin ligase from the TSC2 complex xref ."
29622767
TSC1 binds TSC2, MYC, and Hemagglutinins. 1 / 1
| 1
sparser
"Next, we co-transfected HeLa cells with different forms of myc-TSC1 with HA-TSC2 and treated with nocodazole."
29559472
TSC1 binds TSC2, RRAGB, TBC1D7, and MADS3. 1 / 1
| 1
sparser
"Likewise, we find increased binding of TSC2, TSC1 and TBC1D7 to the Rag GTPases in response to various stresses ( xref ), in agreement with relocalization of the entire TSC complex to lysosomes."
26868506
TSC1 binds TSC2 and TRX1. 1 / 1
| 1
sparser
"We showed that pUL38 interacts with TSC1 and TSC2 in cells infected with wild-type cytomegalovirus."
18407068
RHEB binds TSC1, TSC2, TBC1D17, and JUN. 1 / 1
| 1
sparser
"Growth factors and cytokines promote the activation of MTORC1 by inhibiting the tuberous sclerosis complex, a complex of TSC1, TSC2, and TBC1D17 that is the GTPase activator protein (GAP) for the ras-like small GTPase Rheb xref ."
30647914
TSC1 binds TSC2 and RHOA. 1 / 1
| 1
sparser
"Because TSC2 binds TSC1 ( xref , xref ; xref ) by the domain that overlaps the Rho-activating domain of TSC1 and potentially inhibits TSC1-dependent Rho activation, we investigated whether or not stress fiber disassembly involves TSC1."
15611338
FH affects FLCN, MET, MITF, PTEN, PYD1, TFE3, TFEB, TSC1, TSC2, and VHL
| 1
TFE3 binds TFEB, TSC1, TSC2, VHL, FLCN, FH, MET, MITF, PTEN, and PYD1. 1 / 1
| 1
sparser
"Currently there are at least twelve different genes associated with the development of kidney cancer, the VHL , MET , FLCN , TSC1 , TSC2 , TFE3, TFEB, MITF, fumarate hydratase (FH), succinate dehydrogenase B (SDHB), succinate dehydrogenase D ( SDHD) , and PTEN genes."
22705279
ERK affects TSC2
| 1
ERK binds TSC1 and TSC2. 1 / 1
| 1
sparser
"As a result, upon abrogation of basal levels of Erk activity, wild-type TSC2 binds TSC1 as strongly as TSC2 S664A/S540A , suggesting that the observed stronger interaction between TSC1 and the TSC2 S6[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15851026
E3_Ub_ligase affects TSC2
| 1
E3_Ub_ligase binds TSC1 and TSC2. 1 / 1
| 1
sparser
"Also it is suggested that TSC1 interacts with TSC2 to stabilize TSC2 by excluding HERC1 ubiquitin ligase from the TSC2 complex xref ."
29622767
DUSP5 affects DUSP6, PEBP1, PPP2, PTEN, TSC1, and TSC2
| 1
PPP2 binds TSC1, TSC2, DUSP5, DUSP6, PEBP1, and PTEN. 1 / 1
| 1
sparser
"However, the regulation of this pathway is a rather complex process and there are also many tumor suppressor proteins interacting with this pathway such as PTEN, RKIP, PP2A, DUSP5, DUSP6, TSC1, and TSC2 [ xref ]."
29296181
D1 affects TSC2
| 1
TSC1 binds TSC2 and D1. 1 / 1
| 1
reach
"It was suggested that TSC1 and TSC2 complex may regulate Cyclin D1 expression through canonical Wnt and beta-catenin signaling."
25639352
CTNNB1 affects Wnt
| 1
AXIN binds Wnt, TSC1, TSC2, and CTNNB1. 1 / 1
| 1
sparser
"Both TSC1 and TSC2 are able to associate with Axin and β-catenin in the canonical Wnt pathway, and an absence of either TSC1 or TSC2 has shown to increase Wnt signaling ( Mak, Takemaru, Kenerson, Moon[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30086265
CIB2 affects TSC2
| 1
TSC1 binds TSC2, CIB2, RPTOR, and MTOR. 1 / 1
| 1
sparser
"To gain insights into the molecular mechanism of CIB2-mediated mTORC1 modulation, we assessed direct interactions between CIB2 and TSC1, TSC2, mTORC1-specific subunit Raptor, mTOR kinase, and Rheb, using a previously reported nanoscale pulldown 2.0 (NanoSPD) quantitative interaction assay xref ."
34162842
CCNB1 affects TSC2
| 1
TSC1 binds TSC2, CCNB1, MTOR, and Ribosomal Protein S6. 1 / 1
| 1
sparser
"This allows the formation of an active TSC1-TSC2 dimer that inhibits the phosphorylation of Ribosomal Protein S6 Kinase B1 (RPS6KB1) by the mTOR protein complex, which in turn inhibits the phosphorylation of Ribosomal Protein S6 (RPS6), part of the 40S ribosomal subunit required for initiation [ xref ]."
33477877
AXIN affects Wnt
| 1
AXIN binds Wnt, TSC1, TSC2, and CTNNB1. 1 / 1
| 1
sparser
"Both TSC1 and TSC2 are able to associate with Axin and β-catenin in the canonical Wnt pathway, and an absence of either TSC1 or TSC2 has shown to increase Wnt signaling ( Mak, Takemaru, Kenerson, Moon[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30086265
ATP6AP1 affects mTORC1
| 1
MTORC1 binds TSC1, TSC2, HERC1, and ATP6AP1. 1 / 1
| 1
sparser
"TSC subunit 1 (TSC1) stabilizes TSC2 by inhibiting the interaction between TSC2 and HERC1, forming a TSC1-TSC2 complex that negatively regulates mTORC1."
32921582
ARSD affects TSC2
| 1
TSC1 binds TSC2 and ARSD. 1 / 1
| 1
sparser
"ASD was not associated with TSC1 or TSC2 mutations ( P = 1.0)."
23445896
AMPK affects TP53
| 1
AMPK binds TP53, TSC1, TSC2, and MTOR. 1 / 1
| 1
sparser
"The antioxidant response of p53 also inhibits the mTOR pathway via the Sestrins, which are induced by p53 and can interact with mTOR pathway suppressors AMPK, TSC1 and TSC2 [ xref ]."
21340684
AMPK affects SESN2, TSC1, and TSC2
| 1
AMPK binds TSC1, TSC2, and SESN2. 1 / 1
| 1
sparser
"To study whether a complex containing Sesn2, TSC1, TSC2 and AMPK can form under more physiological conditions, we immunoprecipitated lysates of MCF7-tet OFF Sesn2F or MCF7-tet OFF GFP cells with the Flag antibody."
18692468
AMPK affects MTOR, TP53, TSC1, and TSC2
| 1
AMPK binds TP53, TSC1, TSC2, and MTOR. 1 / 1
| 1
sparser
"The antioxidant response of p53 also inhibits the mTOR pathway via the Sestrins, which are induced by p53 and can interact with mTOR pathway suppressors AMPK, TSC1 and TSC2 [ xref ]."
21340684
AKT1 affects AKT3, DEPDC5, FCD, MMP12, MTOR, NPRL2, PIK3CA, TSC1, and TSC2
| 1
sparser
"Our data confirm the association of mutations in AKT1, AKT3, DEPDC5, MTOR, NPRL2, PIK3CA, TSC1 , and TSC2 with FCD or HME, and show that “two-hit” germline and somatic TSC2 mutations can cause isolated HME."
29281825
293T affects TSC2
| 1
TSC1 binds TSC2 and 293T. 1 / 1
| 1
reach
"Consistent with these transfection studies, we could also detect the interaction of endogenous FIP200 with the endogenous TSC1 and TSC2 complex in 293T cells (XREF_FIG E)."
16043512