IndraLab

Statements

PRPF8 affects SNRNP200
7 | 5 19
PRPF8 binds SNRNP200.
7 | 2 16
PRPF8 binds SNRNP200. 10 / 13
7 | 1 5
biogrid
No evidence text available
23704370
biogrid
No evidence text available
22939629
biogrid
No evidence text available
27173435
biogrid
No evidence text available
16723661
sparser
"Moreover, they also report that a loss of PHF6 results in increased genomic instability at rDNA genes and a cell cycle delay at G2/M. While this was the first indication of a nucleolar function for PHF6, it has also been reported to interact with PRPF8 and SNRNP200, both constituents of the U4/U6-U5 tri-snRNP pre-mRNA splicing ribonucleoprotein complex [ xref ]."
26103525
sparser
"In addition, a small but reproducible reduction of SNRNP200 and PRPF8 binding was also observed in the case of the Δ201–250 deletion mutant."
34131137
biogrid
No evidence text available
26344197
biogrid
No evidence text available
17317632
biogrid
No evidence text available
16723661
reach
"The conservative missense variant p.PRPF8-Arg2310Lys that is not altering the global charge of the C-terminal tail, and variants located at the basis of the C-terminal tail show milder clinical phenotypes, in accordance with functional data on PRPF8 and SNRNP200 interactions in yeast."
29087248
PRPF8 binds EFTUD2 and SNRNP200. 7 / 7
| 1 6
sparser
"AAR2, ZNHIT2, and the HSP90/R2TP complex associate with the U5-specific proteins EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Remarkably, the GFP-ZNHIT2 SILAC IP revealed a strong association of this factor with EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Notably, depletion of the spliceosome components BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP [ xref ], most strongly phenocopy PRPF8 deficiency (Fig.  xref ; Additional file xref b, c)."
26392272
sparser
"Similarly, in humans, yeast two-hybrid and in vitro binding assays have demonstrated physical interactions between EFTUD2, SNRNP200 and PRPF8 proteins ( xref , xref ), and these interactions have been confirmed by recent cryo-EM structures of the human U4/U6."
33584830
sparser
"Importantly, our results suggest that components of Complex B, and more specifically BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP complex [ xref ], phenocopy PRPF8 most strongly."
26392272
sparser
"Specifically, TSSC4 interacts with U5-specific proteins PRPF8, EFTUD2 and SNRNP200."
34131137
reach
"In addition to the PRPF8, EFTUD2, and SNRNP200 complex, our proteomics analysis as well as previous analyses found that SNW1 was in complex with another splicing subcomplex, PRP19 complex."
25450007
sparser
"Because Snrnp40 is tightly bound to Prpf8, Eftud2, and Snrnp200, it is likely that Snrnp40 also participates and facilitates these processes."
31427773
PRPF8 binds COPS5 and SNRNP200. 1 / 1
| 1
sparser
"A recent 7Å cryo-electron microscopy (cryo-EM) structure of the human tri-snRNP revealed that SNRNP200 interacts with the PRPF8 Jab1 domain, the region of PRPF8 containing the majority of PRPF8 RP-linked variants ( xref ; xref )."
33584830
PRPF8 binds LAP3, EFTUD2, and SNRNP200. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
PRPF8 binds SNRNP200 and TSSC4. 1 / 1
| 1
sparser
"The tethering assay (Fig.  xref ) shows that TSSC4 binding to PRPF8, SNRNP200, and EFTUP2 can occur already in the cytoplasm, which suggests that TSSC4 interaction with RHC components happens primarily during their biogenesis."
34131137
PRPF31 binds PRPF8, PRPF3, SNRNP200, and ATXN3. 1 / 1
| 1
sparser
"Hypomorphic mutations in the core spliceosomal components PRPF3, PRPF8, PRPF31, and SNRNP200 are associated with autosomal dominant retinitis pigmentosa, a disease characterized by progressive retinal degeneration."
22819011
PRPF8 inhibits SNRNP200.
| 1 3
PRPF8 inhibits SNRNP200. 4 / 4
| 1 3
sparser
"In humans, phosphorylation of Prp6 that occurs after the tri-snRNP being integrated into the B-complex may release the inhibition of Brr2 by Prp8 and is important for spliceosomal B-complex activation [ xref , xref ]."
27058959
sparser
"A model was proposed in which inhibition of Brr2 by the ubiquitinated Prp8 leads to spliceosome assembly and stabilization of the triple snRNP (U4/U6–U5)."
| PMC
sparser
"Given the mechanistic analogy between histone mRNA processing and splicing, we thus envisage that SLBP ubiquitylation may suppress hPrp43 helicase activity in histone mRNA processing similar to Prp8 u[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27203182
reach
"The RNase H domain of PRPF8 inhibits loading of SNRNP200 to U4 snRNA, and a C-terminal part of PRPF8 modulates the SNRNP200 activity for the unwinding of U4/U6 snRNA duplex XREF_BIBR - XREF_BIBR."
25450007
PRPF8 activates SNRNP200.
| 2
PRPF8 activates SNRNP200. 2 / 2
| 2
reach
"Although it has been demonstrated that the PRPF8 RNase H domain inhibits SNRNP200 activity and GTP bound EFTUD2 and that the C-terminus of PRPF8 induces the activation of SNRNP200 XREF_BIBR - XREF_BIBR, the detailed molecular mechanisms of the activation of SNRNP200 remains to be determined."
25450007
reach
"The RNase H domain of PRPF8 inhibits loading of SNRNP200 to U4 snRNA, and a C-terminal part of PRPF8 modulates the SNRNP200 activity for the unwinding of U4/U6 snRNA duplex XREF_BIBR - XREF_BIBR."
25450007
SNRNP200 affects PRPF8
7 | 3 16
SNRNP200 binds PRPF8.
7 | 2 16
PRPF8 binds SNRNP200. 10 / 13
7 | 1 5
biogrid
No evidence text available
23704370
biogrid
No evidence text available
22939629
biogrid
No evidence text available
27173435
biogrid
No evidence text available
16723661
sparser
"Moreover, they also report that a loss of PHF6 results in increased genomic instability at rDNA genes and a cell cycle delay at G2/M. While this was the first indication of a nucleolar function for PHF6, it has also been reported to interact with PRPF8 and SNRNP200, both constituents of the U4/U6-U5 tri-snRNP pre-mRNA splicing ribonucleoprotein complex [ xref ]."
26103525
sparser
"In addition, a small but reproducible reduction of SNRNP200 and PRPF8 binding was also observed in the case of the Δ201–250 deletion mutant."
34131137
biogrid
No evidence text available
26344197
biogrid
No evidence text available
17317632
biogrid
No evidence text available
16723661
reach
"The conservative missense variant p.PRPF8-Arg2310Lys that is not altering the global charge of the C-terminal tail, and variants located at the basis of the C-terminal tail show milder clinical phenotypes, in accordance with functional data on PRPF8 and SNRNP200 interactions in yeast."
29087248
PRPF8 binds EFTUD2 and SNRNP200. 7 / 7
| 1 6
sparser
"AAR2, ZNHIT2, and the HSP90/R2TP complex associate with the U5-specific proteins EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Remarkably, the GFP-ZNHIT2 SILAC IP revealed a strong association of this factor with EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Notably, depletion of the spliceosome components BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP [ xref ], most strongly phenocopy PRPF8 deficiency (Fig.  xref ; Additional file xref b, c)."
26392272
sparser
"Similarly, in humans, yeast two-hybrid and in vitro binding assays have demonstrated physical interactions between EFTUD2, SNRNP200 and PRPF8 proteins ( xref , xref ), and these interactions have been confirmed by recent cryo-EM structures of the human U4/U6."
33584830
sparser
"Importantly, our results suggest that components of Complex B, and more specifically BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP complex [ xref ], phenocopy PRPF8 most strongly."
26392272
sparser
"Specifically, TSSC4 interacts with U5-specific proteins PRPF8, EFTUD2 and SNRNP200."
34131137
reach
"In addition to the PRPF8, EFTUD2, and SNRNP200 complex, our proteomics analysis as well as previous analyses found that SNW1 was in complex with another splicing subcomplex, PRP19 complex."
25450007
sparser
"Because Snrnp40 is tightly bound to Prpf8, Eftud2, and Snrnp200, it is likely that Snrnp40 also participates and facilitates these processes."
31427773
PRPF8 binds COPS5 and SNRNP200. 1 / 1
| 1
sparser
"A recent 7Å cryo-electron microscopy (cryo-EM) structure of the human tri-snRNP revealed that SNRNP200 interacts with the PRPF8 Jab1 domain, the region of PRPF8 containing the majority of PRPF8 RP-linked variants ( xref ; xref )."
33584830
PRPF8 binds LAP3, EFTUD2, and SNRNP200. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
PRPF8 binds SNRNP200 and TSSC4. 1 / 1
| 1
sparser
"The tethering assay (Fig.  xref ) shows that TSSC4 binding to PRPF8, SNRNP200, and EFTUP2 can occur already in the cytoplasm, which suggests that TSSC4 interaction with RHC components happens primarily during their biogenesis."
34131137
PRPF31 binds PRPF8, PRPF3, SNRNP200, and ATXN3. 1 / 1
| 1
sparser
"Hypomorphic mutations in the core spliceosomal components PRPF3, PRPF8, PRPF31, and SNRNP200 are associated with autosomal dominant retinitis pigmentosa, a disease characterized by progressive retinal degeneration."
22819011
SNRNP200 deubiquitinates PRPF8.
| 1
SNRNP200 deubiquitinates PRPF8. 1 / 1
| 1
reach
"Following de-ubiquitination of Prp8, Brr2 is free to promote unwinding of U4/U6, resulting in activation of the spliceosome [48]."
| PMC
PLIN2 affects PRPF3, PRPF31, PRPF8, REG3A, SNRNP200, and TOPORS
| 1
PRPF31 binds PRPF8, PRPF3, TOPORS, PLIN2, SNRNP200, and REG3A. 1 / 1
| 1
sparser
"Among the genes involved in mRNA splicing, mutations in PRPC8 (human homolog of yeast pre-mRNA splicing factor C8), PRP31 (human homolog of yeast pre-mRNA splicing factor 31), HPRP3 (human homolog of yeast pre-mRNA splicing factor 3), PAP-1 (PIM-1 kinase), TOPORS (topoisomerase-I-binding arginine/serine-rich protein) and SNRNP200 (small nuclear ribonucleoprotein, 200 kDa) are associated with adRP [ xref - xref ], although the mechanisms behind the process remain unclear."
20519033
PDAP1 affects PLIN2, PRPF3, PRPF31, PRPF8, and SNRNP200
| 1
PDAP1 binds PRPF31, PRPF8, PRPF3, PLIN2, and SNRNP200. 1 / 1
| 1
sparser
"Other essential components of the spliceosome, PRPF31, PRPF3, PRPF8, PAP1 and SNRNP200 , have been associated with adRP [ xref - xref ]."
21496248
LAP3 affects SNRNP200
| 1
PRPF8 binds LAP3, EFTUD2, and SNRNP200. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
EFTUD2 affects SNRNP40
| 1
sparser
"Because Snrnp40 is tightly bound to Prpf8, Eftud2, and Snrnp200, it is likely that Snrnp40 also participates and facilitates these processes."
31427773
EFTUD2 affects LAP3, PRPF8, and SNRNP200
| 1
PRPF8 binds LAP3, EFTUD2, and SNRNP200. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
COPS5 affects SNRNP200
| 1
PRPF8 binds COPS5 and SNRNP200. 1 / 1
| 1
sparser
"A recent 7Å cryo-electron microscopy (cryo-EM) structure of the human tri-snRNP revealed that SNRNP200 interacts with the PRPF8 Jab1 domain, the region of PRPF8 containing the majority of PRPF8 RP-linked variants ( xref ; xref )."
33584830
ATXN3 affects SNRNP200
| 1
PRPF31 binds PRPF8, PRPF3, SNRNP200, and ATXN3. 1 / 1
| 1
sparser
"Hypomorphic mutations in the core spliceosomal components PRPF3, PRPF8, PRPF31, and SNRNP200 are associated with autosomal dominant retinitis pigmentosa, a disease characterized by progressive retinal degeneration."
22819011
AAR2 affects ECD, EFTUD2, PRP8, PRPF8, and SNRNP200
| 1
AAR2 binds ECD, PRPF8, EFTUD2, SNRNP200, and PRP8. 1 / 1
| 1
sparser
"A recent study by Claudius et al demonstrated that human ECD can rescue splicing defects in drosophila induced by deletion of fly Ecd and Ecd also interacts with a complex containing Prp8, Aar2, Brr2 and Snu114 proteins [ xref ]."
28492064