IndraLab

Statements


2 10 4 | 3 105 204

sparser
"MTOR-WGA (cell periphery marker) and mTOR-Rheb co-localization was greater in LEAA compared to PLA irrespective of time-point (p<0.05)."

reach
"It is activated by Akt and PKB, which phosphorylates tuberin (TSC2) at multiple sites relieving the inhibitory effects of the hamartin-tuberin (TSC1-TSC2) complex on Rheb and mTOR complex 1 (mTORC1) [XREF_BIBR - XREF_BIBR]."

sparser
"Active Rheb binds mTOR promoting its activation."

sparser
"The lead compound they developed is a dimeric quinacrine (DQ661), which is derived from Lys05, has improved lysosomal targeting capability and impairs the activity of palmitoyl-protein thioesterase (PPT1), which is required for mTOR interaction with Rheb at the lysosome [ xref ]; inhibition of PPT1 also prevents mTORC1 from associating with the lysosomal membrane, causing mTOR inhibition [ xref ]."

reach
"Consistent with the notion that the endomembrane may serve as a platform for the assembly of a functional Rheb and mTOR complex, treatment of cells with brefeldin A interferes with transmission of Rheb signals to p70S6K."

No evidence text available

reach
"Because TSC2 functions as a GAP for Rheb, inhibition of its activity promotes the binding of Rheb with mTOR, thereby enhancing mTORC1 function."

sparser
"Because protein-protein interactions are important in mediating signaling events, the association of Rheb with mTOR was assessed."

sparser
"EtOH also decreased the interaction of Rheb with mTOR, and this was prevented by Leu."

reach
"The TSC heteromeric complex formed by TSC1, TSC2 and TBC1D7 acts as a GTPase activating protein (GAP) for the small Ras related GTPase Rheb, which, in active GTP bound form, binds and activates mTOR."
RHEB binds RPS6 and MTOR. 1 / 1
| 1

sparser
"A constitutively active form of RHEB, RHEB-Q64L, which stimulates S6 phosphorylation through the activation of MTOR signaling, was transfected into U2OS cells to recover MTOR activity."