IndraLab

Statements

RAF1 affects KRAS
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KRAS binds RAF1. 10 / 165
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"The c-Raf-RBD normally binds to KRas when KRas is GTP-bound (KRas GTP )."
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"In other words, the Raf1 and K-Ras complexes will not lose their positioning in the cell membrane while association occurs in the cell membrane, and unless they are separated."
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"The structures of the KRAS and RBDCRD complex provide atomic details of the KRAS-CRD interaction interface, which is similar in size to the KRAS-RBD interface and also consists of nine hydrogen bonds (Supplementary Fig4a-c)."
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"Our simulations showed that these quaternary complexes were highly stable with confined KRas4B membrane orientation, supported by the Raf-1 interactions with both KRas4B and membrane."
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"Next, we determined whether everolimus treatment enhances the interaction of mt K-Ras and c-Raf for the Ras-Raf-ERK activation."
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"Cells expressing higher KRAS levels quickly convert GDP-KRAS to GTP-KRAS by increased upstream EGFR signaling and maintain the GTP-KRAS-CRAF interaction downstream by AURKA signaling, ultimately leading to cell cycle progression and escape from G0 [ xref ]."
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"Together, our observations support the conclusion that KRAS D154Q does not impair the interaction between KRAS and CRAF and that KRAS dimerization is not required for CRAF-KRAS interactions.Finally, w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although the K-Ras/Raf-RBD interaction was readily detectable upon co-expression in a single cell line, or following lysis of co-cultured cell lines separately expressing K-Ras and RBD, bearing in mind the limitations of our assay, we were unable to detect the interaction in the intact, co-cultured cell lines or upon treatment of the Raf-RBD-expressing cells with exosomes containing K-Ras."
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"Raf-1 bound KRas4B has the lowest fluctuations in α 1-L2 and interswitch regions but the highest in Switch-II region."
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"We optimized DoMY-Seq by taking advantage of the well-described and high-affinity interaction between KRAS and CRAF, and we provide high resolution domain mapping on this and other protein interacting pairs, including CRAF-MEK1, RIT1-RGL3, and p53-MDM2."
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RAS binds KRAS and RAF1. 5 / 5
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"Structural superposition of WT KRAS-RBDCRD with all three mutant structures shows similar interaction interfaces, suggesting that the two RAS-binding domains of RAF1 bind to oncogenic KRAS mutants similarly to WT KRAS (Fig.  xref )."
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"In fact, the interaction between these two proteins was first described in a Y2H screening and largely occurs through interaction of the N-terminal (aa 56–131) Ras-binding domain (RBD) of CRAF and the effector-binding domain of KRAS (aa 32–40) in a GTP-dependent manner ( xref , xref )."
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"Subsequent interaction of the RAF1 RAS binding domain with KRAS does not significantly change G-domain configurations on the membrane but affects their relative populations."
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"KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation."
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"Analysis of the canonical RAS-RAF-MEK-ERK signaling cascade ( xref ) after reversion of the mesenchymal H157 and H1155 KRAS mutant cells to an epithelial state through induced, stable, or transient expression of miR-200, showed an increase in KRAS binding to the RAS binding domain (RBD) of RAF1 (CRAF), followed by activation of MAPK signaling ( xref and xref , xref )."
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HRAS binds KRAS and RAF1. 3 / 3
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"Kobe0065, and a less potent analog (Kobe2602) identified by similarity searching, inhibited HRAS- and KRAS:RAF-RBD binding in vitro ."
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"Recently, xref , xref reported that a calmodulin inhibitor induced association of HRas and KRas with Raf1 in COS-1 cells."
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"KRAS mutations, unlike mutations of RAF1 and HRAS, are rarely associated with HCM."
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KRAS binds RAF1 and RBD. 2 / 2
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"This suggests that in addition to the high-affinity binding of RAF1 to KRAS provided by RBD, proper CRD association with KRAS is required for robust RAF1 activation."
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"High-throughput sequencing enables interacting domain mapping of KRAS binding to CRAF RBD."
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FGFR2 binds KRAS, PIK3CA, and RAF1. 1 / 1
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"In the current study, we have also observed that all patients with ERBB2 alterations (N=8) harbored at least one co-alteration, including anomalies in FGFR2 , RAF1 , PIK3CA and KRAS that can be associated with resistance to anti-HER2 regimens ( xref , patient ID: 1, 4, 17, 30, 32, 33, 47 and 53)."
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KRAS binds RAF1 and RAF1. 1 / 1
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"In addition, the KRAS:CRAF/RAF1(RBD-CRD) structure determined by Tran and colleagues is nearly identical to the recently reported HRAS:CRAF/RAF1(RBD-CRD) structure at 2.8 Å, indicating that all RAS isoforms are likely to interact with the CRAF/RAF1(RBD-CRD) in a similar manner ( xref )."
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RAF binds BRAF, KRAS, ARAF, and RAF1. 1 / 1
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"Activated KRAS binds and activates RAF family kinases, RAF1, BRAF, and ARAF [ xref ]."
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BRAF affects CBL, GNL3, KRAS, MAP2K1, NRAS, PTPN11, RAF1, SHOC2, and SOS1
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BRAF binds SOS1, CBL, SHOC2, GNL3, KRAS, MAP2K1, NRAS, PTPN11, and RAF1. 2 / 2
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"NS is associated with PTPN11 , SOS1 , KRAS , NRAS , RAF1 , BRAF , SHOC2 , MEK1 and CBL gene mutations [ xref - xref ], LS with PTPN11, RAF1 and BRAF gene mutations [ xref , xref , xref , xref ], NS/LAH with SHOC2 gene mutations [ xref ], CFCS with KRAS , BRAF , MEK1 and MEK2 gene mutations [ xref , xref ], CS with HRAS gene mutations [ xref ]."
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"NS is associated with mutations in PTPN11 , SOS1 , KRAS , NRAS , RAF1 , BRAF , SHOC2 , MEK1 and CBL [ xref , xref , xref , xref , xref , xref , xref , xref ], CS with mutations in HRAS [ xref ], CFCS with mutations in KRAS , BRAF , MEK1 and MEK2 [ xref , xref ], NS/LAH with mutations in SHOC2 [ xref ], LS with mutations in PTPN11 , RAF1 and BRAF [ xref , xref , xref ]."
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RAF1 affects RAF
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RAF binds BRAF, KRAS, ARAF, and RAF1. 1 / 1
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"Activated KRAS binds and activates RAF family kinases, RAF1, BRAF, and ARAF [ xref ]."
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RAF1 affects PIK3CA
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FGFR2 binds KRAS, PIK3CA, and RAF1. 1 / 1
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"In the current study, we have also observed that all patients with ERBB2 alterations (N=8) harbored at least one co-alteration, including anomalies in FGFR2 , RAF1 , PIK3CA and KRAS that can be associated with resistance to anti-HER2 regimens ( xref , patient ID: 1, 4, 17, 30, 32, 33, 47 and 53)."
30348637
RAF1 affects BRAF
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RAF binds BRAF, KRAS, ARAF, and RAF1. 1 / 1
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"Activated KRAS binds and activates RAF family kinases, RAF1, BRAF, and ARAF [ xref ]."
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PIK3CA affects RAF1
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FGFR2 binds KRAS, PIK3CA, and RAF1. 1 / 1
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"In the current study, we have also observed that all patients with ERBB2 alterations (N=8) harbored at least one co-alteration, including anomalies in FGFR2 , RAF1 , PIK3CA and KRAS that can be associated with resistance to anti-HER2 regimens ( xref , patient ID: 1, 4, 17, 30, 32, 33, 47 and 53)."
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KRAS affects RAF
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RAF binds BRAF, KRAS, ARAF, and RAF1. 1 / 1
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"Activated KRAS binds and activates RAF family kinases, RAF1, BRAF, and ARAF [ xref ]."
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KRAS affects PIK3CA
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FGFR2 binds KRAS, PIK3CA, and RAF1. 1 / 1
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"In the current study, we have also observed that all patients with ERBB2 alterations (N=8) harbored at least one co-alteration, including anomalies in FGFR2 , RAF1 , PIK3CA and KRAS that can be associated with resistance to anti-HER2 regimens ( xref , patient ID: 1, 4, 17, 30, 32, 33, 47 and 53)."
30348637
KRAS affects BRAF
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RAF binds BRAF, KRAS, ARAF, and RAF1. 1 / 1
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"Activated KRAS binds and activates RAF family kinases, RAF1, BRAF, and ARAF [ xref ]."
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FGFR2 affects RAF1
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FGFR2 binds KRAS, PIK3CA, and RAF1. 1 / 1
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"In the current study, we have also observed that all patients with ERBB2 alterations (N=8) harbored at least one co-alteration, including anomalies in FGFR2 , RAF1 , PIK3CA and KRAS that can be associated with resistance to anti-HER2 regimens ( xref , patient ID: 1, 4, 17, 30, 32, 33, 47 and 53)."
30348637
BRAF affects RAF1
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RAF binds BRAF, KRAS, ARAF, and RAF1. 1 / 1
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"Activated KRAS binds and activates RAF family kinases, RAF1, BRAF, and ARAF [ xref ]."
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"For example, NS is associated with mutations in A2ML1 , CBL , KRAS , LZTR1 , MAP3K8 , MYST4 , NRAS , PTPN11 , RAF1 , RASA2 , RRAS , RIT1 , SHOC2 , SOS1 , SOS2 and SPRY1 , whereas mutations in HRAS and SPRED1 have been described for CS and Legius syndrome, respectively ( xref ; xref , xref )."
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