IndraLab

Statements

CYLD affects NFKBIA
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CYLD activates NFKBIA.
| 2
CYLD activates NFKBIA. 1 / 2
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"Consistent with the notion that NF-kappaB signalling could be turned off through negative feedback mechanism involving CYLD mediated ubiquitin (Ub) deconjugation [XREF_BIBR], the CYLD depletion compromised and CYLD overexpression potentiated cell apoptosis are separately overrided by NF-kappaB inhibitor BAY 11-7085 and IkappaBalpha siRNA."
29050336
CYLD-C601A activates NFKBIA. 1 / 1
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"Consistent with our previous study [XREF_BIBR], the inhibitory function of CYLD on NF-kappaB relies on its intact catalytic activity because expression of a catalytically inactive CYLD C601A mutant, in which cysteine601 is substituted by alanine, could not enhance the abundance of IkappaBalpha to the equivalent extent as wild-type CYLD did (XREF_SUPPLEMENTARY)."
29050336
CYLD inhibits NFKBIA.
| 2
CYLD inhibits NFKBIA. 2 / 2
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"Treatment with BAY 11-7085, a known NF-kappaB antagonist that blocks IkappaBalpha phosphorylation and NF-kappaB transactivation, effectively abrogated the CYLD siRNA induced IkappaBalpha degradation."
29050336
reach
"While the CYLD deficiency slightly decreased the basal expression levels of IkappaBalpha and IkappaBbeta proteins, it did not affect the basal expression of IkappaBepsilon in RASMCs (XREF_FIG)."
22406061
CYLD dephosphorylates NFKBIA.
| 1
Mutated CYLD leads to the dephosphorylation of NFKBIA. 1 / 1
| 1
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"This led to permanent inhibition of the NFkappaB pathway by the inactivation resistant CYLD mutant and result in slightly diminished phosphorylation of I-kappaBalpha."
23335970
CYLD decreases the amount of NFKBIA.
| 1
Modified CYLD decreases the amount of NFKBIA. 1 / 1
| 1
reach
"In this study, high glucose inhibited expression of IkappaBalpha was significantly reversed by the overexpression of CYLD, and p-IkappaBalpha, NF-kappaBp65, and p-NF-kappaBp65 proteins levels were significantly decreased."
29259980
NFKBIA affects CYLD
| 1
NFKBIA activates CYLD. 1 / 1
| 1
sparser
"Endogenous MALT1 activity was evaluated by western blotting for A20, BCL10, and CYLD, and NF-κB activation by phospho-IκB-α and total IκB-α ( xref )."
23238016
sparser
"The 21 core genes associated with the RIG-I-like receptor signaling pathway included IFIH1, TRIM25, NFKB1, DHX58, DDX3X, IRF7, ISG15, DDX58, TRAF2, MAPK11, RELA, CXCL8, TBK1, IL12B, RIPK1, NFKBIA, CYLD, IL12A, TNF, AZI2 , and TANK ."
34490145