IndraLab

Statements

COPS5 affects COPS8
12 2 | 6 10
COPS5 binds COPS8.
12 2 | 1 10
COPS8 binds COPS5. 7 / 31
12 2 | 1 6
sparser
"The best characterized of these intracellular effectors is the COP9-signalosome subunit 5 (CSN5), which is an important determinant of cullin-dependent protein turnover ( xref , xref )."
33324425
reach
"Notably, decreases in CSN8 reduced significantly CSN3, CSN5, and CSN7 but not other 4 CSN subunits (XREF_FIG), suggesting that CSN8 may directly interact CSN3, CSN5 and CSN7 during the formation of CSN holo- and mini-complexes and stabilize them."
18706515
sparser
"Although the exact site where exosomal protein sorting is regulated by CSN5-associated COP9 deubiquitin activity is unknown, it is significant that we identified that CSN5-associated with COP9 possess[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19246649
sparser
"We have shown that deubiquitinase activity of CSN5 is associated with COP9."
19246649
sparser
"Also, E2/GPER pathway downregulated PD-L1 through COP9-signalosome subunit 5 degradation, as reported in melanoma and pancreatic ductal adenocarcinoma ( xref , xref )."
37941543
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"Also plausible is that a deubiquitin enzyme associated with CSN5 or other subunits of COP9 may initiate the reaction, and CSN5 regulates the activity of its associated deubiquitin enzyme since COP9-as[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19246649
sparser
"Knockout of COP9-signalosome subunit 5 (CSN5) suppresses the deneddylation of cullin and leads to cardiac hypertrophy and heart failure [24,25] ."
35661710
COPS5 binds COPS8 and PDLIM2. 2 / 2
| 2
sparser
"These results confirm that PDLIM2 binds to CSN5 and CSN8."
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"From this we observed PDLIM2 binding to the CSN5 and CSN8 peptides, slightly to CSN3, but not to CSN1, 2, 4, 6, or 7 ( xref and Supplemental Table S5)."
24196835
COPS5 binds COPS8 and UNC. 1 / 1
| 1
sparser
"One of the COP9 subunits, CSN-5, interacts with UNC-98 and UNC-96 ( Miller et al. 2009 )."
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REFA1 binds COPS5 and COPS8. 1 / 1
| 1
sparser
"Namely, these 14 genes code for the cytoplasmic ribosomal constituents RpL26, RpL6 and RpS5b, which associate with RpS6 [ xref ], the mitochondrial ribosomal constituents mRpL13, mRpL41, mRpL52 and mRpS30, which bind to mRpL55 [ xref ], the COP9 signalosome component CSN1b, which associates with CSN5 and CSN8 [ xref , xref ], Hsp70Bc and EF1α (100)E, which are linked to Hsc70-4 [ xref ], the replication factor RfC4, which associates with RfC1 [ xref ], as well as Wds, l(2)dtl and Cul4, which bind to DDB1 [ xref ]."
20540764
COPS5 activates COPS8.
| 3
COPS5 activates COPS8. 3 / 3
| 3
reach
"CUL3-Δ9 has been shown to display loss of interaction with several components of the COP9 signalosome (CSN) including CSN5 (also called JAB1) , CSN4 , and CSN8 ."
36861484
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"The COP9 signalosome CSN5 subunit plays an important role in the responses of multiple plants to adverse stresses."
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"For example, the Phytophthora capsici RxLR effector PcSnel4 targets NbCSN5 to suppress HR during infection by impairing the interaction and colocalisation of COP9 signalosome 5 (CSN5) and Cullin1 (CUL1), disrupting HR accumulation (Gao et al. 2023)."
39980173
COPS5 inhibits COPS8.
| 1
COPS5 inhibits COPS8. 1 / 1
| 1
reach
"Down-regulation of COPS5 in mouse embryonic fibroblasts drastically decreased the stability of COPS1, COPS3, and COPS8 [XREF_BIBR - XREF_BIBR]."
27903243
COPS5 increases the amount of COPS8.
| 1
COPS5 increases the amount of COPS8. 1 / 1
| 1
reach
"Of note, CSN5 knock-down led to significantly reduced CSN1 and CSN8 levels, indicating that CSN5 is critical for the stability of the entire CSN complex.A distinguishing feature of Jab1/CSN5 is that i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30468907
COPS8 affects COPS5
12 2 | 4 10
COPS8 binds COPS5.
12 2 | 1 10
COPS8 binds COPS5. 7 / 31
12 2 | 1 6
sparser
"The best characterized of these intracellular effectors is the COP9-signalosome subunit 5 (CSN5), which is an important determinant of cullin-dependent protein turnover ( xref , xref )."
33324425
reach
"Notably, decreases in CSN8 reduced significantly CSN3, CSN5, and CSN7 but not other 4 CSN subunits (XREF_FIG), suggesting that CSN8 may directly interact CSN3, CSN5 and CSN7 during the formation of CSN holo- and mini-complexes and stabilize them."
18706515
sparser
"Although the exact site where exosomal protein sorting is regulated by CSN5-associated COP9 deubiquitin activity is unknown, it is significant that we identified that CSN5-associated with COP9 possess[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19246649
sparser
"We have shown that deubiquitinase activity of CSN5 is associated with COP9."
19246649
sparser
"Also, E2/GPER pathway downregulated PD-L1 through COP9-signalosome subunit 5 degradation, as reported in melanoma and pancreatic ductal adenocarcinoma ( xref , xref )."
37941543
sparser
"Also plausible is that a deubiquitin enzyme associated with CSN5 or other subunits of COP9 may initiate the reaction, and CSN5 regulates the activity of its associated deubiquitin enzyme since COP9-as[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19246649
sparser
"Knockout of COP9-signalosome subunit 5 (CSN5) suppresses the deneddylation of cullin and leads to cardiac hypertrophy and heart failure [24,25] ."
35661710
COPS5 binds COPS8 and PDLIM2. 2 / 2
| 2
sparser
"These results confirm that PDLIM2 binds to CSN5 and CSN8."
24196835
sparser
"From this we observed PDLIM2 binding to the CSN5 and CSN8 peptides, slightly to CSN3, but not to CSN1, 2, 4, 6, or 7 ( xref and Supplemental Table S5)."
24196835
COPS5 binds COPS8 and UNC. 1 / 1
| 1
sparser
"One of the COP9 subunits, CSN-5, interacts with UNC-98 and UNC-96 ( Miller et al. 2009 )."
23146617
REFA1 binds COPS5 and COPS8. 1 / 1
| 1
sparser
"Namely, these 14 genes code for the cytoplasmic ribosomal constituents RpL26, RpL6 and RpS5b, which associate with RpS6 [ xref ], the mitochondrial ribosomal constituents mRpL13, mRpL41, mRpL52 and mRpS30, which bind to mRpL55 [ xref ], the COP9 signalosome component CSN1b, which associates with CSN5 and CSN8 [ xref , xref ], Hsp70Bc and EF1α (100)E, which are linked to Hsc70-4 [ xref ], the replication factor RfC4, which associates with RfC1 [ xref ], as well as Wds, l(2)dtl and Cul4, which bind to DDB1 [ xref ]."
20540764
COPS8 increases the amount of COPS5.
| 2
COPS8 increases the amount of COPS5. 2 / 2
| 2
reach
"The decrease in CSN8 suppressed protein levels of CSN3, CSN5 and CSN7 but had little effect on CSN1, CSN2, CSN4, and CSN6 protein levels (XREF_FIG)."
18706515
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"Mechanistically, CCL5 leads to the formation of the nuclear factor κρρa p65/STAT3 complex, which binds to the COP9 signal 5 (CSN5) promoter to upregulates CSN5 gene expression."
37141250
COPS8 activates COPS5.
| 1
COPS8 activates COPS5. 1 / 1
| 1
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"Consistently, CSN8 knockdown reduced the abundance of CSN8 and CSN5 in both holo- and mini-complexes."
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