IndraLab

Statements

COPS8 affects COPS5
9 3 | 3 8
COPS8 binds COPS5.
9 3 | 1 8
COPS5 binds COPS8. 10 / 26
9 2 | 1 4
hprd
No evidence text available
11285227
hprd
No evidence text available
11337588
biogrid
No evidence text available
28514442
sparser
"The best characterized of these intracellular effectors is the COP9-signalosome subunit 5 (CSN5), which is an important determinant of cullin-dependent protein turnover ( xref , xref )."
33324425
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19295130
reach
"Notably, decreases in CSN8 reduced significantly CSN3, CSN5, and CSN7 but not other 4 CSN subunits (XREF_FIG), suggesting that CSN8 may directly interact CSN3, CSN5 and CSN7 during the formation of CSN holo- and mini-complexes and stabilize them."
18706515
biogrid
No evidence text available
27173435
biogrid
No evidence text available
18850735
PDLIM2 binds COPS5 and COPS8. 2 / 2
| 2
sparser
"From this we observed PDLIM2 binding to the CSN5 and CSN8 peptides, slightly to CSN3, but not to CSN1, 2, 4, 6, or 7 ( xref and Supplemental Table S5)."
24196835
sparser
"These results confirm that PDLIM2 binds to CSN5 and CSN8."
24196835
COPS5 binds COPS8 and UNC. 1 / 1
| 1
sparser
"One of the COP9 subunits, CSN-5, interacts with UNC-98 and UNC-96 ( Miller et al. 2009 )."
23146617
COPS5 binds COPS8 and REFA1. 1 / 1
| 1
sparser
"Namely, these 14 genes code for the cytoplasmic ribosomal constituents RpL26, RpL6 and RpS5b, which associate with RpS6 [ xref ], the mitochondrial ribosomal constituents mRpL13, mRpL41, mRpL52 and mRpS30, which bind to mRpL55 [ xref ], the COP9 signalosome component CSN1b, which associates with CSN5 and CSN8 [ xref , xref ], Hsp70Bc and EF1α (100)E, which are linked to Hsc70-4 [ xref ], the replication factor RfC4, which associates with RfC1 [ xref ], as well as Wds, l(2)dtl and Cul4, which bind to DDB1 [ xref ]."
20540764
COPS5 binds COPS8, COPS2, GFER, and GPS1. 1 / 1
1 |
hprd
No evidence text available
15304329
COPS8 increases the amount of COPS5.
| 1
COPS8 increases the amount of COPS5. 1 / 1
| 1
reach
"The decrease in CSN8 suppressed protein levels of CSN3, CSN5 and CSN7 but had little effect on CSN1, CSN2, CSN4, and CSN6 protein levels (XREF_FIG)."
18706515
COPS8 activates COPS5.
| 1
COPS8 activates COPS5. 1 / 1
| 1
reach
"Consistently, CSN8 knockdown reduced the abundance of CSN8 and CSN5 in both holo- and mini-complexes."
18706515
COPS5 affects COPS8
9 3 | 2 8
COPS5 binds COPS8.
9 3 | 1 8
COPS5 binds COPS8. 10 / 26
9 2 | 1 4
hprd
No evidence text available
11285227
hprd
No evidence text available
11337588
biogrid
No evidence text available
28514442
sparser
"The best characterized of these intracellular effectors is the COP9-signalosome subunit 5 (CSN5), which is an important determinant of cullin-dependent protein turnover ( xref , xref )."
33324425
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19295130
reach
"Notably, decreases in CSN8 reduced significantly CSN3, CSN5, and CSN7 but not other 4 CSN subunits (XREF_FIG), suggesting that CSN8 may directly interact CSN3, CSN5 and CSN7 during the formation of CSN holo- and mini-complexes and stabilize them."
18706515
biogrid
No evidence text available
27173435
biogrid
No evidence text available
18850735
PDLIM2 binds COPS5 and COPS8. 2 / 2
| 2
sparser
"From this we observed PDLIM2 binding to the CSN5 and CSN8 peptides, slightly to CSN3, but not to CSN1, 2, 4, 6, or 7 ( xref and Supplemental Table S5)."
24196835
sparser
"These results confirm that PDLIM2 binds to CSN5 and CSN8."
24196835
COPS5 binds COPS8 and UNC. 1 / 1
| 1
sparser
"One of the COP9 subunits, CSN-5, interacts with UNC-98 and UNC-96 ( Miller et al. 2009 )."
23146617
COPS5 binds COPS8 and REFA1. 1 / 1
| 1
sparser
"Namely, these 14 genes code for the cytoplasmic ribosomal constituents RpL26, RpL6 and RpS5b, which associate with RpS6 [ xref ], the mitochondrial ribosomal constituents mRpL13, mRpL41, mRpL52 and mRpS30, which bind to mRpL55 [ xref ], the COP9 signalosome component CSN1b, which associates with CSN5 and CSN8 [ xref , xref ], Hsp70Bc and EF1α (100)E, which are linked to Hsc70-4 [ xref ], the replication factor RfC4, which associates with RfC1 [ xref ], as well as Wds, l(2)dtl and Cul4, which bind to DDB1 [ xref ]."
20540764
COPS5 binds COPS8, COPS2, GFER, and GPS1. 1 / 1
1 |
hprd
No evidence text available
15304329
COPS5 inhibits COPS8.
| 1
COPS5 inhibits COPS8. 1 / 1
| 1
reach
"Down-regulation of COPS5 in mouse embryonic fibroblasts drastically decreased the stability of COPS1, COPS3, and COPS8 [XREF_BIBR - XREF_BIBR]."
27903243
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, and GPS1
2 |
hprd
No evidence text available
9535219
hprd
No evidence text available
12220626
UNC affects COPS8
| 1
COPS5 binds COPS8 and UNC. 1 / 1
| 1
sparser
"One of the COP9 subunits, CSN-5, interacts with UNC-98 and UNC-96 ( Miller et al. 2009 )."
23146617
REFA1 affects COPS8
| 1
COPS5 binds COPS8 and REFA1. 1 / 1
| 1
sparser
"Namely, these 14 genes code for the cytoplasmic ribosomal constituents RpL26, RpL6 and RpS5b, which associate with RpS6 [ xref ], the mitochondrial ribosomal constituents mRpL13, mRpL41, mRpL52 and mRpS30, which bind to mRpL55 [ xref ], the COP9 signalosome component CSN1b, which associates with CSN5 and CSN8 [ xref , xref ], Hsp70Bc and EF1α (100)E, which are linked to Hsc70-4 [ xref ], the replication factor RfC4, which associates with RfC1 [ xref ], as well as Wds, l(2)dtl and Cul4, which bind to DDB1 [ xref ]."
20540764
GPS1 affects GFER
1 |
COPS5 binds COPS8, COPS2, GFER, and GPS1. 1 / 1
1 |
hprd
No evidence text available
15304329
COPS8 affects UNC
| 1
COPS5 binds COPS8 and UNC. 1 / 1
| 1
sparser
"One of the COP9 subunits, CSN-5, interacts with UNC-98 and UNC-96 ( Miller et al. 2009 )."
23146617
COPS8 affects REFA1
| 1
COPS5 binds COPS8 and REFA1. 1 / 1
| 1
sparser
"Namely, these 14 genes code for the cytoplasmic ribosomal constituents RpL26, RpL6 and RpS5b, which associate with RpS6 [ xref ], the mitochondrial ribosomal constituents mRpL13, mRpL41, mRpL52 and mRpS30, which bind to mRpL55 [ xref ], the COP9 signalosome component CSN1b, which associates with CSN5 and CSN8 [ xref , xref ], Hsp70Bc and EF1α (100)E, which are linked to Hsc70-4 [ xref ], the replication factor RfC4, which associates with RfC1 [ xref ], as well as Wds, l(2)dtl and Cul4, which bind to DDB1 [ xref ]."
20540764
COPS8 affects GPS1
1 |
COPS5 binds COPS8, COPS2, GFER, and GPS1. 1 / 1
1 |
hprd
No evidence text available
15304329
COPS5 affects UNC
| 1
COPS5 binds COPS8 and UNC. 1 / 1
| 1
sparser
"One of the COP9 subunits, CSN-5, interacts with UNC-98 and UNC-96 ( Miller et al. 2009 )."
23146617
COPS5 affects REFA1
| 1
COPS5 binds COPS8 and REFA1. 1 / 1
| 1
sparser
"Namely, these 14 genes code for the cytoplasmic ribosomal constituents RpL26, RpL6 and RpS5b, which associate with RpS6 [ xref ], the mitochondrial ribosomal constituents mRpL13, mRpL41, mRpL52 and mRpS30, which bind to mRpL55 [ xref ], the COP9 signalosome component CSN1b, which associates with CSN5 and CSN8 [ xref , xref ], Hsp70Bc and EF1α (100)E, which are linked to Hsc70-4 [ xref ], the replication factor RfC4, which associates with RfC1 [ xref ], as well as Wds, l(2)dtl and Cul4, which bind to DDB1 [ xref ]."
20540764
COPS5 affects GPS1
1 |
COPS5 binds COPS8, COPS2, GFER, and GPS1. 1 / 1
1 |
hprd
No evidence text available
15304329
COPS5 affects COPS8, and UNC
| 1
COPS5 binds COPS8 and UNC. 1 / 1
| 1
sparser
"One of the COP9 subunits, CSN-5, interacts with UNC-98 and UNC-96 ( Miller et al. 2009 )."
23146617
COPS5 affects COPS8, and REFA1
| 1
COPS5 binds COPS8 and REFA1. 1 / 1
| 1
sparser
"Namely, these 14 genes code for the cytoplasmic ribosomal constituents RpL26, RpL6 and RpS5b, which associate with RpS6 [ xref ], the mitochondrial ribosomal constituents mRpL13, mRpL41, mRpL52 and mRpS30, which bind to mRpL55 [ xref ], the COP9 signalosome component CSN1b, which associates with CSN5 and CSN8 [ xref , xref ], Hsp70Bc and EF1α (100)E, which are linked to Hsc70-4 [ xref ], the replication factor RfC4, which associates with RfC1 [ xref ], as well as Wds, l(2)dtl and Cul4, which bind to DDB1 [ xref ]."
20540764
COPS5 affects COPS2
1 |
COPS5 binds COPS8, COPS2, GFER, and GPS1. 1 / 1
1 |
hprd
No evidence text available
15304329
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, GPS1, and TP53
1 |
TP53 binds COPS4, COPS7A, COPS6, COPS3, COPS5, COPS8, COPS2, and GPS1. 1 / 1
1 |
hprd
No evidence text available
11285227
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, CUL4A, and GPS1
1 |
hprd
No evidence text available
11337588
hprd
No evidence text available
11337588
SKP1 binds FBXO3, FBXO6, COPS4, COPS7A, COPS7B, COPS6, COPS3, COPS5, COPS8, CUL1, COPS2, EEF2, GPS1, and RBX1. 1 / 1
1 |
hprd
No evidence text available
11337588