A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

vemurafenib affects RAF1
| 2 3
Vemurafenib binds RAF1. 5 / 5
| 2 3
reach
"Additionally, vemurafenib has been found to induce the trans-activation of WT-BRAF or CRAF through hetero-dimerization between vemurafenib bound BRAF V600E and WT-BRAF or CRAF."
reach
"The data suggest that binding of PLX to CRAF induces activation of the enzyme and, subsequently, ERK signaling."
sparser
"To test whether direct binding of PLX to CRAF is required for induction of signaling, we generated a catC carrying a mutation at the gatekeeper position (T421) in the kinase domain (mutations used and their properties are in xref )."
sparser
"The data suggest that binding of PLX to CRAF induces activation of the enzyme and, subsequently, ERK signaling."
reach
"To test whether direct binding of PLX to CRAF is required for induction of signaling, we generated a catC carrying a mutation at the gatekeeper position (T421) in the kinase domain (mutations used and their properties are in XREF_SUPPLEMENTARY)."
RAF1 affects vemurafenib
| 2 3
Vemurafenib binds RAF1. 5 / 5
| 2 3
reach
"Additionally, vemurafenib has been found to induce the trans-activation of WT-BRAF or CRAF through hetero-dimerization between vemurafenib bound BRAF V600E and WT-BRAF or CRAF."
reach
"The data suggest that binding of PLX to CRAF induces activation of the enzyme and, subsequently, ERK signaling."
sparser
"To test whether direct binding of PLX to CRAF is required for induction of signaling, we generated a catC carrying a mutation at the gatekeeper position (T421) in the kinase domain (mutations used and their properties are in xref )."
sparser
"The data suggest that binding of PLX to CRAF induces activation of the enzyme and, subsequently, ERK signaling."
reach
"To test whether direct binding of PLX to CRAF is required for induction of signaling, we generated a catC carrying a mutation at the gatekeeper position (T421) in the kinase domain (mutations used and their properties are in XREF_SUPPLEMENTARY)."