
IndraLab
Statements
Vemurafenib binds BRAF. 10 / 13
|
11
1
reach
"The crystal structures of the BRAF and V600E complex with PLX7904 (pdb id 4XV1), the BRAF V600E mutant bound with PLX7922 (pdb id 4XV3), and the BRAF and PLX5568 complex (pdb id 4XV9) have revealed a binding mode and interaction profiles that are highly reminiscent of the BRAF and Vemurafenib complex."
Vemurafenib binds BRAF-V600E. 9 / 9
|
9
reach
"Based on prior structural data of MEK1-BRAF, vemurafenib bound V600E BRAF, and MEK1-KSR2 and structural alignments of vemurafenib bound V600E BRAF with BRAF or KSR2, we hypothesized a regulatory V600E BRAF- MUT MEK complex where V600E BRAF arginine 662 makes critical contacts with MEK residues in one complex interface (XREF_FIG)."
Vemurafenib binds mutated BRAF. 2 / 2
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2
Vemurafenib binds BRAF and F595. 1 / 1
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1
Vemurafenib binds mutated BRAF and V600. 1 / 1
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1