IndraLab

Statements

CDK4 affects CCND1
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CCND1 binds CDK4. 10 / 611
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"To find out the potential therapeutic strategies, we screened the combination of inhibitors against the FGF/FGFR signaling pathway and the CCND1/CDK4 complex and revealed that gefitinib combined with LY2874455 and abemaciclib exhibited the most effective inhibition of resistance in vitro and in vivo ."
35814257
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"This substitution blocks binding of CDK4 to p16 INK4A , but preserves the CDK4-CCND1 interaction, resulting in a constitutively active CDK4/CCND1 complex."
18613999
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"We further revealed the molecular mechanism by which nuclear-localized GHR regulates MSCs proliferation, and found that nuclear-targeted GHR enhanced the phosphorylation of STAT5, and the activated STAT5 initiates the transcription of CyclinD1, after which, the complex of CyclinD1 and CDK4 further phosphorylates Rb, and the activated Rb releases E2F1, the released E2F1 ultimately realizes the biological function of GH promoting cell proliferation."
34866251
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"Progression through G1 phase typically requires the association of cyclin D1 with CDK4 [ 20 ]."
29287202
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"Down-regulation of cyclin D1 and CDK4 expression by TBBX resulted from the disruption of Hsp90 with cyclin D1 and CDK4 complex and led to proteasome degradation ( xref A)."
25946558
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"PCNA plays an important role in DNA repair and was found to be associated with the CDK4 and CCND1 complex (X2)."
7607576
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"CyclinD1 is a cell cycle regulator and forms a complex with CDK4 ( xref , xref )."
34220863
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"An additional layer of complexity is provided by phosphorylation of p27 at Y74, performed by Src and other non-receptor tyrosine kinases, an event that was first thought to convert p27 from an inhibitor to a non-inhibitor of cyclin D1-CDK4 ( xref , xref , xref , xref )."
33166394
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"The biochemical studies revealed that INSM1 binds to cyclin D1 and interrupts cyclin D1 and CDK4 binding, which induces non-NE cell cycle arrest ( xref )."
31113827
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"In our study, NGF exposure mediated the activation of Trk-A and further promoted the upregulation of PI3K/Akt signaling transduction followed by the increase of CyclinD1-CDK4."
31208396
CCND1 binds CDK4 and CDK6. 10 / 54
| 54
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"The activation of cyclin D1, which subsequently interacts with CDK4 or CDK6, leads to the inactivation of the restrictive G1 checkpoint, suppressing cell cycle arrest. xref In our study, DCZ0858 induced cell cycle arrest in the G0/G1 phase and inhibited cell transition into the S phase."
32257397
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"In contrast, overexpression of CDK4 or CCND1 alone resulted in no rescue, suggesting that binding of CCND1 to endogenous CDK4 or CDK6 is not sufficient to protect HSPCs from differentiation-inducing signals."
26150472
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"As a regulatory subunit of cyclin-dependent kinase (CDK), cyclin D1 forms complexes with CDK4 and CDK6, which were a central mediator in the transition from G1 to S phase."
27708248
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"The active form of STAT3 was found to promote the G/S phase transition of the cell cycle through the expression of cyclin D1, which can associate with cdk4 or cdk6 and control progression from G to S [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24388873
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"The binding of cyclin D1 with Cdk4 ( xref ) or Cdk6 ( xref ) was suppressed by Rh2 treatment."
19629651
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"CDK6 interacts with CDK4 and CCND1 to form a complex which is fundamental for Rb function and G1/S transition."
| PMC
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"Hyperphosphorylation of the retinoblastoma (Rb) gene product pRb is mediated in early G 1 by CDK4 and CDK6 interacting with cyclin D 1 ."
19874578
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"In the presence of mitogenic stimuli and abundant nutrients, cyclin D1 is synthesized; to perform its functions, cyclin D1 assembles with CDK4 or CDK6 to form a kinase complex; conversely, growth factor withdrawal or nutrient depletion compromises the formation of new cyclin D1-CDK4/6 complexes, leading to an immediate degradation of cyclin D1 in order to facilitate cell cycle exit [ xref ]."
32006569
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"In human cells, cyclin D1 interacts with CDK4 and CDK6 to form holoenzymes and then phosphorylates the tumor-suppressor protein Rb in G1 phase, which is important for cell cycle progression. xref The E2F transcription factor binds to Rb and is released when Rb is phosphorylated, inducing the expression levels of a series of genes, such as cyclin E, cyclin A, PCNA and MCM7, which are involved in entry into S phase of the cell division cycle. xref Our study showed that SH treatment downregulated the expression levels of the cell cycle-positive regulators, including CDK4, cyclin D1, cyclin E, phospho-Rb, PCNA and MCM7."
25077542
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"Once produced, cyclin D1 binds to either cyclin dependent kinase 4 (CDK4) or CDK6, dependent on cell type, and serves to activate the kinase moiety (Figure xref )."
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CCND1 binds CDK4 and CDKN1B. 10 / 25
1 | 24
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"While TGF-beta inhibited the formation of cyclin D1-cdk4-p27 complexes in 184(S) cells, it did not inhibit the assembly of cyclin D1-cdk4-p27 complexes in the resistant 184A1L5(R) cells."
11940657
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"The proteins p27, CDK4, and cyclin D1 are associated with the cell cycle and proliferation [ xref – xref ]."
32206038
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"p16 dissociated cyclin D1-Cdk4 complexes with the release of bound p27(KIP1), while Cdk4(N158) formed complexes with cyclin D1 and p27."
9710613
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"While p27KD reduces the concentration of the assembled p27-cyclin D1-cdk4 ternary complex, removing PD’s target, it would also release cdk2, which has been shown competent to drive proliferation in the absence of cdk4 ( xref )."
29330290
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"In addition, the binding of the CDK2 inhibitor p27 to CDK2 was decreased in AMBRA1 -knockout cells and cells expressing cyclin D1(T286A), and at the same time p27 was more abundantly bound to cyclin D1 and CDK4 ( xref , xref , xref )."
33854239
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"The interaction between p27 KIP1 , cyclin D1, and CDK4 was enhanced by galectin-3 depletion."
24971481
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"Hsc70 interacts with CDK inhibitor p27, which regulates the assembly and subcellular localization of cyclin D1-CDK4-p27 complex."
26481195
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"Interestingly, such phenomenon was not observed in the PDAC model (1222), further confirming that only a very small fraction of cyclin D1 and CDK4 could form complex with p27 due to its low baseline expression ( xref )."
33323381
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"In proliferating 184A1L5(R) cells, more p27 was associated with cyclin D1-cdk4 complexes than in 184(S)."
11940657
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"The interaction between p27 KIP1 , cyclin D1, and CDK4 was also decreased by galectin-3 overexpression."
24971481
CCND1 binds CDK4 and RB1. 10 / 10
| 10
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"Interestingly, the interaction between Rb and E2F1 was strongly detected in the absence of galectin-3, although Rb did not interact with cyclin D1 and CDK4 ( xref )."
24971481
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"It may be that 8q affects the formation of CDK4 and cyclin D1 complexes, which is the key step to regulate Rb [ xref , xref ]."
32708403
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"TNC regulates the cyclin D1-CDK4 complex formation and activity of Rb through regulation of FOXO1/β-catenin/p27 Kip1 ."
30519351
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"To investigate the requirement for p53 and Rb activity in senescence-associated OPN regulation, we ectopically expressed a well-characterized dominant negative p53 cDNA (p53-DD) ( xref ) or a cDNA expressing a fusion protein consisting of a mutant form of cyclin dependent kinase 4 R24C (Cdk4) and cyclin D1 (DK) that inhibits Rb ( xref ) ( xref )."
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"CyclinD1 binds and activates cyclin-dependent kinase CDK4 to phosphorylate inhibitory protein Rb protein in Gl phase [ xref , xref ]."
30038385
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"Upregulation of cyclin D1 in HNSCC cell lines is specifically associated with resistance to gefitinib by hyperphosphorylation of retinoblastoma protein (pRb) by cyclin D1-cyclin dependent kinase 4 (CDK4) ( xref )."
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"The results in Fig. xref C indicate that the ectopic expression of TNC enhanced the formation of the cyclin D1-CDK4 complex and Rb phosphorylation."
30519351
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"In fact, the proline-rich N-terminal portion of INSM1 has recently been shown to specifically bind cyclin D1, a key cell cycle regulator, and that through this interaction, INSM1 interrupts the interaction between cyclin D1 and cyclin-dependent kinase 4 (CDK4), which subsequently inhibits Rb phosphorylation [ xref ]."
21609490
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"To better understand the mechanism that TNC promotes the formation of the cyclin D1-CDK4 complex and Rb phosphorylation, we performed an immunoprecipitation assay using anti-CDK4 followed by a western blot with anti-cyclin D1."
30519351
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"2,3,7,8 tetrachlorodibenzo- p -dioxin (TCDD) is a lipophilic toxicant that inhibits estrogen signaling and disrupts interactions between CCND1, CDK4, and RB1 ( xref , xref )."
25699021
CCND1 binds CDK4, CDK6, and RB1. 4 / 4
1 | 3
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"We found that high expression of CDK4, CDK6, CCND1, and phospho-RB1 was associated with higher proliferative index, as defined by MKI67."
28991877
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No evidence text available
9380698
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"The proliferation-promoting action of isoprenaline was abolished by a β1-selective antagonist and was more effectively abolished by a β2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was associated with decreased cyclin D1, CDK-4, CDK-6 and phospho-Rb expression."
23286511
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"As a key mediator of cell cycle progression, cyclin D1 forms complex with cyclin-dependent kinase 4 (CDK4) and CDK6 to inactivate the retinoblastoma (RB) pathway via hyperphosphorylation of the RB protein and result in acceleration of E2F-mediated gene transcription xref ."
28602785
CCND1 binds CCND1 and CDK4. 3 / 3
| 3
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"Consistent with previous reports, both cyclin D1a and cyclin D1b effectively interact with CDK4 (Lu et al , xref ) (Supplementary Fig xref )."
25787974
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"In many cell types, transcription of CCND1 and cyclin D1 assembly with CDK4 each depend on activation of a RAS-dependent kinase cascade that relies on the sequential activities of RAF1, MEK1 and MEK2, and ERKs ( xref - xref )."
26658964
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"Immunoprecipitation analysis revealed that cyclin D1a and cyclin D1-T286A could bind to cyclin-dependent kinase 4 (CDK4) but cyclin D1b has lost its capacity to associate with CDK4."
19415719
E2F binds CCND1, CDK4, and RB1. 2 / 2
| 2
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"Interestingly, a review of the literature indicates that E2F, CCND1, CDK4 and pRB form a complex with p21 that is implicit in cell cycle progression [ xref ]."
29689276
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"Interestingly, a review of the literature indicates that E2F, CCND1, CDK4 and pRB form a complex with p21 that is implicit in cell cycle progression ."
29689276
CCND1 binds CDK4 and G1. 2 / 2
| 2
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"If the TAp73 and deltaNp73 isoform ratio is increased by miR-193a-5p in PCa cells, the expression levels of MDM2 and P21 (CDKN1A) might be elevated, and TP73 might function as a tumor suppressor, leading to the reduced effect of the CCND1 and CDK4 complex and G1 arrest."
29467540
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"CDKN1A (also called p21), which is a CDK inhibitor (CKI), can suppress the effects of the CCND1 and CDK4 complex in the G1 phase, leading to G1 arrest."
29467540
CCND1 binds CDK4 and AHR. 2 / 2
| 1 1
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"In this study, the functional interactions between the AHR, CDK4, and cyclin D1 (CCND1) were investigated as a potential mechanism for the cell cycle regulation by the AHR."
19917880
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"In vitro assays for CDK4 kinase activity demonstrated that RB1 phosphorylation by the AHR, CDK4, and CCND1 complex was reduced in the presence of TCDD."
19917880
CCND1 binds CCND2 and CDK4. 1 / 1
| 1
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"However, as RB1 activity is blocked by phosphorylation by the CCND1, CCND2, and CDK4 complex, RB1 function will likely decrease to the benefit of E2F complex activity."
23560086
RAS binds CCND1, CDK4, and NF1. 1 / 1
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"The remaining patients that have neither gene mutation typically have de-regulated kinases including amplification and overexpression of PAK1 [ xref , xref ], inactivation of the NF-1 tumor suppressor [ xref ], loss of NF-1 associated with RAS activation [ xref , xref ] and cell cycle aberrations such as CCND1 and CDK4 amplification [ xref ]."
27447557
CLEC4D binds CCND1, CDK4, CDK6, and MYC. 1 / 1
| 1
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"Among the miR with most prognostic significant impact ( P < 0.01), miR-34a raised our interest because of its association with the control of several relevant genes of MCL pathogenesis, such as CDK4 , CDK6 , MYC , and CCND1 , among others ( xref )."
23640973
CCND1 binds CDK4, CDK8, and NCIT:C95407. 1 / 1
| 1
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"In colon cancer cells, H19 interacts with the macroH2A protein to de-repress the expression of CDK8, CDK4 and CCND1, leading to cell cycle progression [ xref ]."
30159439
CCND1 binds CD44, CDK4, and PLK1. 1 / 1
| 1
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"From the analysis, NSC765600 and NSC765691- CCND1 , CDK4 , PLK1 , and CD44 complexes displayed the highest binding energies of −9.3, −8.3, −7.4 and −7.0 kcal/mol and (−9.6, −8.0, −7.7 and −7.3 kcal/mol, respectively ( xref and xref and accompanying tables), as compared to the standard inhibitors’ results, which were −7.5, −7.6 and −7.9 kcal/mol for fascaplysin, ribociclib, and volasertib- CCND1 , CDK4 , and PLK1, respectively ( xref , accompanying table)."
34063946
CCND1 binds CDK4 and PHY1. 1 / 1
| 1
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"P27 is a key cell cycle protein kinase inhibitor which forms a nuclear complex with CCND1 and CDK4."
24427780
CCND1 binds CDK4 and cdk-4. 1 / 1
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"Future clinical studies need to address whether CCND1 or CDK4 amplification may associate with sensitivity to CDK4/6 inhibitors, as preliminary clinical data suggest for other tumor types [ xref , xref ]."
27207748
CCND1 binds mutated CDK4. 1 / 1
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"However, the CCND1 misbinding mutant CDK4 Delta50-56, lacking the 50-56 aa sequence PISTVRE, still maintained the majority of the interaction with PRMT5."
27708221
CCND1 affects CD46, CDK4, E2F3, EGR2, WTAP, and YBX1
| 1
CCND1 binds WTAP, CDK4, E2F3, EGR2, CD46, and YBX1. 1 / 1
| 1
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"Further, GSEA revealed that KIAA1429, METTL3, and IGF2BP1 were significantly related to multiple biological behaviors, including proliferation, apoptosis, metastasis, energy metabolism, drug resistance, and recurrence, and that KIAA1429 and IGF2BP1 had potential target genes, including E2F3, WTAP, CCND1, CDK4, EGR2, YBX1, and TLX, which were associated with cancers."
32849929
CCND1 affects CD44, CDK4, and PLK1
| 1
CCND1 binds CD44, CDK4, and PLK1. 1 / 1
| 1
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"From the analysis, NSC765600 and NSC765691- CCND1 , CDK4 , PLK1 , and CD44 complexes displayed the highest binding energies of −9.3, −8.3, −7.4 and −7.0 kcal/mol and (−9.6, −8.0, −7.7 and −7.3 kcal/mol, respectively ( xref and xref and accompanying tables), as compared to the standard inhibitors’ results, which were −7.5, −7.6 and −7.9 kcal/mol for fascaplysin, ribociclib, and volasertib- CCND1 , CDK4 , and PLK1, respectively ( xref , accompanying table)."
34063946
CCND1 affects CCND3, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CDKN2B, CDKN2C, CDKN2D, and RB1
| 1
CCND1 binds CCND3, CDK2, CDK4, CDK6, CDKN1A, CDKN2B, CDKN2C, CDKN2D, RB1, and CDKN2A. 1 / 1
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"We have found no evidence that common variations in RB1 , CDK2 , CDK4 , CDK6 , CDKN2A , CDKN2B , CDKN2C , CDKN2D , CCND1 , CCND3 , or CDKN1A are associated with outcome after a diagnosis of ovarian cancer."
18281541
CCND1 affects CCND2, and CDK4
| 1
CCND1 binds CCND2 and CDK4. 1 / 1
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"However, as RB1 activity is blocked by phosphorylation by the CCND1, CCND2, and CDK4 complex, RB1 function will likely decrease to the benefit of E2F complex activity."
23560086