IndraLab

Statements

IRS1 affects IGF1R
1 4 5 | 3 39 97
IGF1R binds IRS1. 10 / 105
1 4 5 | 3 37 50
sparser
"The association of IRS-1 with IGF-1R was increased in GM3S −/− vs. WT KCs by 8-fold after insulin stimulation ( xref , 5 th row, lanes 6 vs. 3) and by 6-fold after IGF-1 stimulation ( xref , 5 th row, lanes 7 vs. 4)."
24326453
reach
"Moreover, HRGbeta1 stimulation also promoted a significant decrease in association between IRS-1 and IGF-IR in both the MCF-7 and T47D cells, and densitometric analysis revealed this reduction to be statistically significant in both cell lines (P < = 0.01 (n = 3) and P < = 0.05 (n = 3), respectively)."
21939528
trips
"Our findings can be summarized as follows: (i) the tyrosine kinase activity of the IGF-IR is essential for the interaction with p52Shc and IRS-1, (ii) p52Shc and IRS-1 bind to the IGF-IR in the NPEY-juxtamembrane motif, (iii) contrary to p52Shc, IRS-1 binds also to the major autophosphorylation sites (Tyr-1131, -1135, and -1136) of the IGF-IR, and (iv) the amino-terminal domain of p52Shc is required for its association with the IR and the IGF-IR."
7559507
sparser
"The interaction of the IGF-I receptor kinase and substrates such as insulin-receptor substrate 1 (IRS-I), a 185 kDa phosphoprotein that is being phosphorylated in response to activation of the IGFq[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8795068
sparser
"TRAF4 overexpression further augmented this interaction ( xref A ), indicating that TRAF4 enhances IGF-1-induced tyrosine phosphorylation of IRS-1 through promoting the interaction between IRS-1 and IGF-1R. The amount of p85 bound to IRS-1 upon IGF-1 stimulation also was significantly increased when TRAF4 is overexpressed, consistent with the level of IRS-1 tyrosine phosphorylation."
33991522
reach
"Immunoprecipitation and Western blot analysis also revealed that, following treatment of MCF-7 and T47D cells with ABDP, there was a reduced association between IRS-1 and IGF-IR and an enhanced association between IRS-1 and erbB3, as shown in Figure XREF_FIG."
21939528
hprd
No evidence text available
12220227
reach
"Ligand activated IGF-1R binds to IRS1, which then binds to the p85 regulatory subunit of PI3K, which then transmits signals to AKT1 and MTOR."
26429980
trips
"Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10."
8776723
sparser
"We propose that (i) the IGF-IR and the IR share at least in part the same molecular mechanism underlying their interplay with their two substrates, p52Shc and IRS-1, and (ii) IRS-1 interacts with the IGF-IR in a fashion that is different from that used by p52Shc."
7559507
IGF1R binds INSR and IRS1. 6 / 6
| 6
sparser
"Thus, IGFIR, IR and IRS-1 bind to hp55 γ in vitro and this binding requires receptor activation."
9524259
sparser
"As expected, stimulation of WT KCs with insulin or IGF-1 led to the association of IRS-1 with IR ( xref , 2 nd row, lanes 3 and 4, respectively) and IGF-1R ( xref , 5 th row, lanes 3 and 4, respectively)."
24326453
sparser
"Activated INSR and IGF1R interact with insulin receptor substrate 1 (IRS1) to activate an intracellular signaling network, including AKT, mTOR, and mitogen‐activated protein kinase 1 (ERK1)/2. xref , xref We then analyzed insulin‐IGF1 signaling in the hearts of CKO and control mice post‐TAC."
| PMC
sparser
"Interaction with proteins that have been reported to interact with insulin receptor and/or IGF-I receptor such as the docking proteins IRS-1, IRS-3 as well as the PI3 kinase regulatory subunit p85, th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15629149
sparser
"As an important mitogen, insulin may promote cancer progression through its binding to the insulin receptor (IR) and/or IGF-1R (insulin-like growth factor receptor), which results in auto-phosphorylation of insulin-receptor substrate-1 (IRS-1) and activation of the phosphatidylinositol 3-kinase (PI3K)/Akt (serine/threonine kinase)/mammalian target of rapamycin (mTOR) pathway and the mitogen-activated protein kinase (MAPK) pathway xref ."
27642100
sparser
"GM3S depletion increases the association of IR, IRS-1, and IGF-1R."
24326453
ESR1 binds IGF1R and IRS1. 3 / 3
| 3
sparser
"Because ectopic expression of ERα reversed the I3C down-regulation of IGF1R and IRS1 transcript expression, the I3C disruption of ERα interactions with the IGF1R and IRS1 promoters mediates the I3C-dependent loss of IGF1R and IRS1 gene expression, respectively."
22835548
sparser
"3.4 I3C disrupts ERα protein interactions with IGF1R and IRS1 promoters."
22835548
sparser
"Our results demonstrate that the I3C mediated down-regulation of ERα causes the loss of ERα binding to the human IGF1R and IRS1 gene promoters and ablation of estrogen dependent transcriptional induction of these two ERα target genes."
22835548
IGF1 binds IGF1R, IRS1, and PIK3CA. 2 / 2
| 2
sparser
"These findings suggest that IGF-I-induced association of p110α with IGF-IR and IRS-1 is enhanced when p110β levels are reduced."
19834495
sparser
"Our results suggest that p110β deficiency leads to increased Akt activation through two separate mechanisms: First, reduced p110β levels enhance the IGF-I-induced association of p110α with IGF-IR and IRS-1."
19834495
ETV6 binds IGF1R, IRS1, and NTRK3. 2 / 2
| 2
sparser
"Further work by the same team has revealed that ETV6–TRKC binds to the IGF1R–IRS1 complex at the plasma membrane; this interaction promotes the recruitment of Src, with consequent activation of the PI3K–AKT signalling cascade and upregulation of MAPK activity and cyclin D1 expression xref ."
30333516
sparser
"Of interest, ETV6-NTRK3 forms a tripartite complex with phosphorylated IRS1 and IGF1R that seems to be critical for the oncogenic action of the chimera."
29455671
IGF1 binds IGF1R, IRS1, PIK3CA, and PIK3CB. 2 / 2
| 2
sparser
"In p110α-deficient cells, IGF-I-induced association of both p110α and p110β with IGF-IR and IRS-1 was reduced, whereas in p110β-deficient cells, association of p110α with IGF-IR and IRS-1 was enhanced ( xref , right)."
19834495
sparser
"Simultaneous knockdown of p110α and p110β prevented IGF-I induced association of both p110α and p110β with IGF-IR and IRS-1."
19834495
SMO binds IGF1R and IRS1. 2 / 2
| 2
sparser
"Furthermore, we show that Smo activity is required for both Shh and IGF-I action and that the IGF-IR and its effector IRS-1 associate with Smo in response to these factors, suggesting that cross talk is already occurring at the receptor level."
21618536
sparser
"The results suggest that the molecular mechanism by which Shh and IGF-I integrate their effect on myoblast proliferation and differentiation can already be found at the receptor level via an interaction of Smo with IGF-IR and IRS-1."
21618536
PI3K binds IGF1R and IRS1. 2 / 2
| 1 1
sparser
"Estradiol also stimulated binding of IRS-1 and PI 3-kinase to the IGF-1R. Depletion of IRS-1 from uterine extracts reduced PI 3-kinase associated with the receptor, which suggests that binding of the enzyme to IGF-1R occurs primarily in a complex that also contains IRS-1."
9565625
reach
"Collectively, these results indicate that UTP did not alter assembly of the IGF-IR, IRS-1, and PI3K complex."
20089844
SHC binds IGF1R and IRS1. 2 / 2
| 2
sparser
"Binding of the adaptor protein Shc and the docking protein IRS-1 to IGF-1R activates the MAPK and PI3/Akt/mTOR signaling pathways, respectively."
23761989
sparser
"Moreover, partial or complete deletion of the C-terminal tail of the IGF-I receptor augments the reporter activity in a yeast two-hybrid assay quantifying the interaction between IRS-1 or Shc with the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15629149
Integrins binds IGF1R and IRS1. 2 / 2
| 2
sparser
"The beta1A integrin forms a complex with the IGF-IR and insulin receptor substrate-1 (IRS-1); this complex does not promote IGF-I mediated cell adhesion to laminin (LN), although it does support IGF-mediated cell proliferation."
15289498
sparser
"The β 1A integrin forms a complex with the IGF-IR and insulin receptor substrate-1 (IRS-1); this complex does not promote IGF-I mediated cell adhesion to laminin (LN), although it does support IGF-mediated cell proliferation."
15289498
ERBB3 binds IGF1R and IRS1. 1 / 1
| 1
sparser
"Importantly, recruitment of IRS-1 by erbB3 reduced IRS-1 association with IGF-IR in MCF-7 and T47D cells, whilst blockade of IGF-IR-enhanced erbB3-IRS-1 interaction and sensitised both cell lines to HRGβ1, allowing HRGβ1 to override IGF-IR blockade."
21939528
PI3K_p85 binds IGF1R and IRS1. 1 / 1
| 1
sparser
"The levels of IGF-1Rβ and p85 bound to IRS-1 also are not elevated in the IRS-1 mutant cells ( xref B )."
33991522
GAB1 binds IGF1R, IRS1, and PTPN11. 1 / 1
| 1
sparser
"It has been reported that splice variants of β 1 integrins selectively modulate IGFR signaling in response to IGF stimulation, forming different complexes with IGFR and IRS-1 (β 1A ) or Gab-1 and SHP2 (β 1C ; Goel et al., xref )."
22649417
PI3K_p85 binds ESR1, IGF1, IGF1R, and IRS1. 1 / 1
| 1
sparser
"IGF1R-mediated signaling was intact as shown by increased phosphorylation of uterine IGF1R, AKT, and mitogen-activated protein kinase, and association of IRS1 and P85 with the IGF1R following IGF1 treatment of ER α -null mice ( xref )."
28586424
IGF1R binds IRS1 and PPP1R12A. 1 / 1
| 1
sparser
"Indeed, previous studies found that PPP1R12A interacted with insulin receptor substrate 1-insulin-like growth factor 1 receptor (IRS1-IGF1R) complex and mediated the process of IRS1 dephosphorylation, promoting PI3K/AKT cascade activation and in turn led to tumor cell proliferation and tumor growth xref , xref ."
34149934
sparser
"InsR or IGF1R binds to IRS-1 via the phosphotyrosine-binding domain and phosphorylates multiple sites on tyrosine in IRS-1, leading to the association with several signaling molecules such as PI3K, GRB2 and SHP2 [ xref , xref ]."
30404198
IGF1 binds IGF1R and IRS1. 1 / 1
| 1
sparser
"Loss of LAR gene product in a mouse knockout model results in reduced fasting levels of insulin, glucose [ xref ] and IGF-1 [ xref ] alongside elevation of IGF-1 stimulated phosphorylation of IGF-1R, IRS1, IRS1 associated PI3K and extracellular signal related kinase (ERK1/2) activity in vascular smooth muscle cells."
19356234
SHC binds GRB10, IGF1R, and IRS1. 1 / 1
| 1
sparser
"Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10."
23730215
GAB1 binds IGF1R and IRS1. 1 / 1
| 1
sparser
"Interestingly, IGF-1R also constitutively associated with its adaptor protein IRS1, and treatment with osimertinib trended to increase the association of IGF-1R with IRS1 and Gab1, but not EGFR."
32929081
IGF1R binds IRS1 and PIK3CA. 1 / 1
| 1
sparser
"In p110α-deficient cells, IGF-I-induced association of both p110α and p110β with IGF-IR and IRS-1 was reduced, whereas in p110β-deficient cells, association of p110α with IGF-IR and IRS-1 was enhanced ( xref , right)."
19834495
IGF1R binds INSR, IRS1, IRS2, and IGFs. 1 / 1
| 1
sparser
"Following the binding of IGFs to IGF-1R or IR, IRS-1 and IRS-2 are phosphorylated, and then PI3K-AKT-mTOR and MAPK pathways are activated [ xref ]."
30911300
Phosphorylated AKT binds IGF1R and IRS1. 1 / 1
| 1
sparser
"TC-71 cells also expressed high levels of IGF-1R, and R1507 decreased steady-state levels of this receptor by internalization/degradation, an effect which was associated with a decrease in p-IGF-1R, p-IRS-1, and p-Akt."
22022506
CAV1 binds IGF1R, INS, and IRS1. 1 / 1
| 1
sparser
"Moreover, Cav-1 directly interact with insulin and IGF1 receptor and their principal substrate IRS-1 supporting a role in metabolic regulation ( xref , xref )."
33935978
SHC binds IGF1R, INSR, and IRS1. 1 / 1
| 1
sparser
"We have recently shown that both SHC and IRS-1 interact with the tyrosine-phosphorylated NPEY motif of the IR and insulin-like growth factor I receptor via non-SH2 domains (Gustafson, T. A., He, W., Craparo, A., Schaub, C. D., and O'Neill, T. J. (1995) Mol."
7559478
IGF1R binds IRS1 and RAD51. 1 / 1
| 1
sparser
"This effect involves an interaction between Rad51 and the major IGF-IR signaling molecule, insulin receptor substrate 1 (IRS-1)."
14559999
EGFR binds IGF1R and IRS1. 1 / 1
| 1
sparser
"Such association with EGFR limited IRS-1 binding to IGF-IR and the activation of the downstream Akt, but treatment with gefitinib shifted IRS-1 back to the IGF-IR signaling."
19030971
IGF1R binds IRS1 and PTK6. 1 / 1
| 1
sparser
"Reverse-phase protein arrays and subsequent analyses revealed that PTK6 forms a complex with IGF-1R and the adaptor protein IRS-1, and modulates anchorage-independent survival by regulating IGF-1R expression and phosphorylation."
20668531
PI3K binds FER, IGF1R, and IRS1. 1 / 1
| 1
sparser
"FER has been associated with signaling complexes containing insulin receptor substrate-1, IGF1R and phosphatidylinositol 3-kinase [ xref ]."
25540073
Adaptor_protein_II binds IGF1R and IRS1. 1 / 1
| 1
sparser
"In the context of endocytosis, IGF1R binds to IRS1–AP2 but does not have MIM xref , xref , suggesting that the internalization of IGF1R does not involve the mitotic checkpoint module and is solely controlled by the IRS module."
32576931
AKT binds ERK, PI3K, IGF1R, and IRS1. 1 / 1
| 1
sparser
"Pharmacological or siRNA inhibition of the IGF1R was associated with a significant reduction in IRS1, PI3K, AKT and ERK phosphorylation."
30328953
ESR1 binds IGF1R, IRS1, and InR. 1 / 1
| 1
reach
"In estrogen receptor-alpha-positive (ERalpha+) breast cancer cells (MCF-7 and T47D), NT157 also resulted in cytoplasmic ERalpha downregulation likely because of disruption of an IRS-1, IGF-IR, InR, and ERalpha complex."
30229539
IGF1R binds IRS1 and ATM. 1 / 1
| 1
sparser
"However, in DU145 cells, where IRS-1 is almost exclusively cytoplasmic ( xref ), we could not detect interaction between ATM and IGF-1R or IRS-1 ( xref ), and there was no evidence of a functional ATM defect in IGF-1R-inhibited cells ( xref )."
24186206
IGF1R binds IRS1 and RB1. 1 / 1
| 1
sparser
"PIK3R3 participates in the regulation of all kinds of tumors and diseases by interacting with the insulin-like growth factor 1 receptor, IRS1 and retinoblastoma protein ( xref ; xref )."
34900997
Cadherin binds Integrins, IGF1R, and IRS1. 1 / 1
| 1
sparser
"It was reported that integrin and cadherin were bound to IRS-1 and the IGF-I receptor ( xref – xref ), and these molecules play roles in cell-cell or cell-extracellular matrix binding ( xref , xref )."
32180762
IGF1R binds IRS1 and IRS2. 1 / 1
| 1
sparser
"Statistically significant associations were noted for the CA repeat in the IGF1 gene with Ki-ras- mutated tumors; IGF1R , IRS1 , and IRS2 were associated mainly with CIMP-positive and MSI tumors."
18992263
CRKL binds FER, IGF1R, and IRS1. 1 / 1
| 1
sparser
"As demonstrated in Figure  xref , IRS1 and IGF1R respectively interact with FER and CRKL, providing additional evidence for crosstalk between FER and CRKL in the activation of the ERK/HIF-1α/NF-κB signaling pathway."
25540073
CASP3 affects CASP8, CASP9, CCNB1, CCND1, CDK1, CYCS, IGF1R, IRS1, JNK, PARP1, and RAC
| 1
JNK binds RAC, CASP3, CASP8, CASP9, CCNB1, CCND1, CDK1, CYCS, PARP1, IGF1R, and IRS1. 1 / 1
| 1
sparser
"Selective inhibition of IGF-IR was associated with caspase-3, caspase-8, caspase-9, and PARP cleavage, cytochrome c release, up-regulation of cyclin B1, and down-regulation of cyclin D1, pCdc2, pIRS-1, pAkt, and pJnk."
21330319
Adaptor_protein_II affects IRS1
| 1
Adaptor_protein_II binds IGF1R and IRS1. 1 / 1
| 1
sparser
"In the context of endocytosis, IGF1R binds to IRS1–AP2 but does not have MIM xref , xref , suggesting that the internalization of IGF1R does not involve the mitotic checkpoint module and is solely controlled by the IRS module."
32576931
ATM affects IRS1
| 1
IGF1R binds IRS1 and ATM. 1 / 1
| 1
sparser
"However, in DU145 cells, where IRS-1 is almost exclusively cytoplasmic ( xref ), we could not detect interaction between ATM and IGF-1R or IRS-1 ( xref ), and there was no evidence of a functional ATM defect in IGF-1R-inhibited cells ( xref )."
24186206
AKT affects PI3K
| 1
AKT binds ERK, PI3K, IGF1R, and IRS1. 1 / 1
| 1
sparser
"Pharmacological or siRNA inhibition of the IGF1R was associated with a significant reduction in IRS1, PI3K, AKT and ERK phosphorylation."
30328953
AKT affects IGF1R, and IRS1
| 1
Phosphorylated AKT binds IGF1R and IRS1. 1 / 1
| 1
sparser
"TC-71 cells also expressed high levels of IGF-1R, and R1507 decreased steady-state levels of this receptor by internalization/degradation, an effect which was associated with a decrease in p-IGF-1R, p-IRS-1, and p-Akt."
22022506
AKT affects ERK, IGF1R, IRS1, and PI3K
| 1
AKT binds ERK, PI3K, IGF1R, and IRS1. 1 / 1
| 1
sparser
"Pharmacological or siRNA inhibition of the IGF1R was associated with a significant reduction in IRS1, PI3K, AKT and ERK phosphorylation."
30328953