IndraLab

Statements

FLT3 phosphorylates itself. 10 / 161
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"Of the 12 FLT3 TKI tested, the majority of them inhibited FLT3 autophosphorylation of wild-type FLT3 with IC 50 values of 20 nM or lower."
28077790
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"Western blot analysis showed that treatment with PKC412 led to dose-dependent decreases in FLT3 autophosphorylation and in phosphorylation of ERK1/2 that correlated with inhibition of cell growth ( Fi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18068628
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"Lestaurtinib, a multi-targeted indolocarbazole derivative that potently inhibits FLT3 autophosphorylation in vitro, has been the most extensively studied agent in clinical trials to date."
21082990
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"We report that AKN-028, a novel tyrosine kinase inhibitor (TKI), is a potent FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor (IC 50 =6 nℳ), causing dose-dependent inhibition of FLT3 autophosphorylation."
22864397
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"As shown in xref , western blot analyses revealed substantially attenuated FL-dependent autophosphorylation of FLT3 in the mutant clones compared to the wild-type K562 clones, although the reduction of total FLT3 protein level was not significant after immunoprecipitation."
26669855
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"FLT3 -ITD mutations, which increase FLT3 autophosphorylation, lead to the activation of RAC1 in AML xref , xref ."
34172833
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"Western blotting confirmed constitutive auto-phosphorylation of the FLT3-receptor and comparable activation of downstream targets such as STAT5 (data not shown)."
26487272
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"LT-171-861 inhibited the autophosphorylation of FLT3 with an IC 50 ≤40 nM, and the inhibition efficacy emerged rapidly after drug administration (Figure xref F-G)."
33391463
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"Interaction with FLT3 ligand causes homo-dimerization, auto-phosphorylation and activation of FLT3 ( xref , xref )."
25053825
trips
"Expression of CBLDeltaexon8 and CBLDeltaexon8+9 in FLT3-WT-Ba/F3 cells induced growth factor-independent proliferation associated with autophosphorylation of FLT3 and activated the downstream targets signal transducer and activator of transcription 5 (STAT5) and protein kinase B (AKT)."
19276253
FLT3 phosphorylates itself on tyrosine. 1 / 1
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"This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules."
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