A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGF affects EGFR, and GRB2
2 | 14
EGF binds EGFR and GRB2. 10 / 16
2 | 14
sparser
"Upon EGF stimulation, Grb2 binds phosphorylated EGFR and activates the signaling pathway xref , xref ."
sparser
"Together these data indicate that AG-1478 inhibits both constitutive as well as EGF-induced EGFR-Grb2 interaction."
sparser
"Preclinical studies revealed cetuximab could decrease cell proliferation and phosphorylation of EGFR, and blocked the binding of the adaptor protein Grb2 to EGFR upon activation by EGF [ xref ]."
sparser
"Interestingly, in spite of the free phosphonate group with its negative charges, CGP78850 inhibited association of Grb2 with EGFR in intact serum-starved MDA-MB-468 triple-negative breast cancer cells stimulated with EGF in vitro ."
sparser
"Our results support the concept that EGFR interacts with Grb2 in both constitutive and EGF-dependent manners and this interaction is independent of HER3 co-expression."
sparser
"1) Association of Grb2 to EGFR in BxPC-3 induced by EGF in the presence of Erbitux indicates an alternate pathway of Ras-MAPK activation, which may be related with the tumor resistance to treatment; 2) transactivation of EGFR downstream Ras-MAPK pathway by FGF contributes the resistance to treatment; and 3) downregulation of EGFR may increase the response to therapy."
sparser
"Compound inhibited epidermal growth factor (EGF)-induced protein–protein interactions between EGFR (EGF receptor) and Grb2 in MDA-MB-468 cells and inhibited Ras activation in the same cell line."
sparser
"We identified that As 2 O 3 activates EGFR and promotes phosphorylation of p66 ShcA and its interaction with the Grb2 adaptor protein with slower kinetics compared to EGF-mediated EGFR activation."
sparser
"Because Ras activation by EGF involves EGF-stimulated association of EGF-R with Grb2, the EGF-R was immunoprecipitated and a Western blot was probed for Grb2."
sparser
"Pre-clinical studies showed cetuximab decreased cell proliferation and phosphorylation of EGFR, and blocked the binding of the adaptor protein Grb2 to EGFR upon activation by EGF [ xref ]."
EGF affects EGFR, GRB2, and SHC
| 2
SHC binds EGF, EGFR, and GRB2. 2 / 2
| 2
sparser
"Dominant-negative forms of SHP-2 had no effect on EGF-stimulated interaction of GRB2 with EGFR or SHC, nor did they influence phosphorylation of SHC and SHC/EGFR association."
sparser
"Experiments with rat liver have demonstrated that following the administration of a bolus of EGF, intracellular EGFR are associated with Shc, Grb2, and mSOS [73] ."
EGF affects EGFR, GRB2, eGFP, and mRFP
| 1
EGF binds EGFR, GRB2, eGFP, and mRFP. 1 / 1
| 1
reach
"The amplitude of the autocorrelation function is inversely related to the cluster density of an EGF, EGFR, eGFP, Grb2, and mRFP complex (eq 4)."
EGF affects EGFR, GRB2, RasGEF, and SHC
| 1
SHC binds EGF, EGFR, GRB2, and RasGEF. 1 / 1
| 1
sparser
"As shown in xref , EGF binds the EGF receptor (EGFR) to recruit RasGEFs such as SOS via its SHC domain and Grb2 adapter protein xref , xref , xref , xref ."
EGF affects EGFR, GRB2, RAS, SHC1, and SOS
| 1
RAS binds SOS, SHC1, EGF, EGFR, and GRB2. 1 / 1
| 1
reach
"This is the first report of yeast cells that can reconstitute a mammalian growth signaling pathway mediated by the EGF, EGFR, Grb2, Shc1, Sos, and Ras complex."
EGF affects EGFR, GRB2, and RAS
| 1
RAS binds EGF, EGFR, and GRB2. 1 / 1
| 1
sparser
"This effect has been associated with reduced EGF-induced EGF receptor (EGFR) tyrosine phosphorylation, Grb-2 association, and Ras activation."
CPD affects EGF, EGFR, GRB2, and SHC
| 1
SHC binds CPD, EGF, EGFR, and GRB2. 1 / 1
| 1
sparser
"Coimmunoprecipitation studies demonstrated that both EGF and Cpd 5 induced tyrosine phosphorylation of EGFR was associated with increased amounts of adapter proteins Shc and Grb2, and the Ras GTP-GDP exchange protein Sos, indicating the formation of functional EGFR complexes."
CBL affects EGF, EGFR, and GRB2
| 1
CBL binds EGF, EGFR, and GRB2. 1 / 1
| 1
sparser
"Consistent with the autophosphorylation data, the EGF-induced interaction of c-Cbl and Grb2 proteins with EGFR was elevated in the controls and lowered in the HER2 cells ( xref ), while the reverse was true for Gab1, p85 (subunit of PI3K) and SHP2."