IndraLab

Statements

GRB2 affects EGFR
2 | 1 20
EGF binds EGFR and GRB2. 10 / 16
2 | 14
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"In a similar way, small molecule compound screens could be done to test for drugs that can specifically disrupt EGFR-Grb2 interactions upon EGF-stimulation ( xref )."
28936468
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"Preclinical studies revealed cetuximab could decrease cell proliferation and phosphorylation of EGFR, and blocked the binding of the adaptor protein Grb2 to EGFR upon activation by EGF [ xref ]."
20046965
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"Interestingly, in spite of the free phosphonate group with its negative charges, CGP78850 inhibited association of Grb2 with EGFR in intact serum-starved MDA-MB-468 triple-negative breast cancer cells stimulated with EGF in vitro ."
25495984
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"Our results support the concept that EGFR interacts with Grb2 in both constitutive and EGF-dependent manners and this interaction is independent of HER3 co-expression."
23700486
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"1) Association of Grb2 to EGFR in BxPC-3 induced by EGF in the presence of Erbitux indicates an alternate pathway of Ras-MAPK activation, which may be related with the tumor resistance to treatment; 2) transactivation of EGFR downstream Ras-MAPK pathway by FGF contributes the resistance to treatment; and 3) downregulation of EGFR may increase the response to therapy."
12850474
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"Because Ras activation by EGF involves EGF-stimulated association of EGF-R with Grb2, the EGF-R was immunoprecipitated and a Western blot was probed for Grb2."
8702944
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"To demonstrate the utility of rsTagRFP as a switchable pcFRET acceptor, we next studied the interaction between EGFR and Grb2 that is induced upon stimulation with epidermal growth factor (EGF) in mammalian cells."
20659687
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"This aspect of the model is consistent with the conventional view that adaptors bind exposed phosphotyrosine residues on receptors and our experiments showing that there is only measurable FRET between EGFR and Grb2 after EGF stimulation."
24697349
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"Upon EGF stimulation, Grb2 binds phosphorylated EGFR and activates the signaling pathway xref , xref ."
30076305
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"Together these data indicate that AG-1478 inhibits both constitutive as well as EGF-induced EGFR-Grb2 interaction."
23700486
SHC binds EGF, EGFR, and GRB2. 2 / 2
| 2
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"Dominant-negative forms of SHP-2 had no effect on EGF-stimulated interaction of GRB2 with EGFR or SHC, nor did they influence phosphorylation of SHC and SHC/EGFR association."
9642214
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"Experiments with rat liver have demonstrated that following the administration of a bolus of EGF, intracellular EGFR are associated with Shc, Grb2, and mSOS [73] ."
12648467
EGF binds EGFR, GRB2, eGFP, and mRFP. 1 / 1
| 1
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"The amplitude of the autocorrelation function is inversely related to the cluster density of an EGF, EGFR, eGFP, Grb2, and mRFP complex (eq 4)."
24697349
SHC binds EGF, EGFR, GRB2, and RasGEF. 1 / 1
| 1
sparser
"As shown in xref , EGF binds the EGF receptor (EGFR) to recruit RasGEFs such as SOS via its SHC domain and Grb2 adapter protein xref , xref , xref , xref ."
28068323
CBL binds EGF, EGFR, and GRB2. 1 / 1
| 1
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"Consistent with the autophosphorylation data, the EGF-induced interaction of c-Cbl and Grb2 proteins with EGFR was elevated in the controls and lowered in the HER2 cells ( xref ), while the reverse was true for Gab1, p85 (subunit of PI3K) and SHP2."
23027125
RAS binds EGF, EGFR, and GRB2. 1 / 1
| 1
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"This effect has been associated with reduced EGF-induced EGF receptor (EGFR) tyrosine phosphorylation, Grb-2 association, and Ras activation."
9422787
SHC binds CPD, EGF, EGFR, and GRB2. 1 / 1
| 1
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"Coimmunoprecipitation studies demonstrated that both EGF and Cpd 5 induced tyrosine phosphorylation of EGFR was associated with increased amounts of adapter proteins Shc and Grb2, and the Ras GTP-GDP exchange protein Sos, indicating the formation of functional EGFR complexes."
10797308
EGF affects EGFR, GRB2, RAS, SHC1, and SOS
| 1
RAS binds SOS, SHC1, EGF, EGFR, and GRB2. 1 / 1
| 1
reach
"This is the first report of yeast cells that can reconstitute a mammalian growth signaling pathway mediated by the EGF, EGFR, Grb2, Shc1, Sos, and Ras complex."
24577528
EGF affects EGFR, GRB2, and RAS
| 1
RAS binds EGF, EGFR, and GRB2. 1 / 1
| 1
sparser
"This effect has been associated with reduced EGF-induced EGF receptor (EGFR) tyrosine phosphorylation, Grb-2 association, and Ras activation."
9422787
EGF affects CPD
| 1
SHC binds CPD, EGF, EGFR, and GRB2. 1 / 1
| 1
sparser
"Coimmunoprecipitation studies demonstrated that both EGF and Cpd 5 induced tyrosine phosphorylation of EGFR was associated with increased amounts of adapter proteins Shc and Grb2, and the Ras GTP-GDP exchange protein Sos, indicating the formation of functional EGFR complexes."
10797308
EGF affects CBL
| 1
CBL binds EGF, EGFR, and GRB2. 1 / 1
| 1
sparser
"Consistent with the autophosphorylation data, the EGF-induced interaction of c-Cbl and Grb2 proteins with EGFR was elevated in the controls and lowered in the HER2 cells ( xref ), while the reverse was true for Gab1, p85 (subunit of PI3K) and SHP2."
23027125
CPD affects SHC
| 1
SHC binds CPD, EGF, EGFR, and GRB2. 1 / 1
| 1
sparser
"Coimmunoprecipitation studies demonstrated that both EGF and Cpd 5 induced tyrosine phosphorylation of EGFR was associated with increased amounts of adapter proteins Shc and Grb2, and the Ras GTP-GDP exchange protein Sos, indicating the formation of functional EGFR complexes."
10797308
CBL affects GRB2
| 1
CBL binds EGF, EGFR, and GRB2. 1 / 1
| 1
sparser
"Consistent with the autophosphorylation data, the EGF-induced interaction of c-Cbl and Grb2 proteins with EGFR was elevated in the controls and lowered in the HER2 cells ( xref ), while the reverse was true for Gab1, p85 (subunit of PI3K) and SHP2."
23027125