IndraLab

Statements


CXCR4 is active.
2 3 |
Tyrosine-phosphorylated CXCR4 is active. 2 / 2
2 |

No evidence text available

No evidence text available
CXCR4 bound to MIF is active. 1 / 1
1 |

"We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF [] By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis."
CXCR4 bound to CD74 is active. 1 / 1
1 |

"Cd74 forms functional complexes with cxcr4 that mediate mif-specific signaling."
CXCR4 bound to CXCL12 is active. 1 / 1
1 |

"To study the role of the sdf-1/cxcr4-chemokine/receptor system as a regulator of vertebrate development, we isolated and characterized a cdna encoding sdf-1 of the lower vertebrate xenopus laevis (xsdf-1). Recombinant xsdf-1 was produced in insect cells, purified, and functionally characterized. Although xsdf-1 is only 64-66% identical with its mammalian counterparts, it is indistinguishable from human (h)sdf-1alpha in terms of activating both x. laevis cxcr4 and hcxcr4. Thus, both xsdf-1 and hsdf-1alpha promoted cxcr4-mediated activation of heterotrimeric g(i2) in a cell-free system and induced release of intracellular calcium ions in and chemotaxis of intact lymphoblastic cells."
CXCR4 is catalytically active.
1 |
CXCR4 is catalytically active. 1 / 1
1 |

"surface CXCR4 expression was down-regulated by cytokines interleukin-4 (IL-4), IL-13, and granulocyte-macrophage colony-stimulating factor (GM-CSF)"