A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

YY1 affects SMAD3
2 | 16 12
2 | 3 12
sparser
"Interestingly, physical interaction between YY1 and Smad3 was dramatically induced by Pg LPS (Fig.  xref B)."
biogrid
No evidence text available
reach
"Interestingly, Smad3 binding to C/EBP1, C/EBP2 and YY1 was increased by PgLPS in a time dependent manner."
reach
"C/EBPbeta and YY1 directly interact with Smad3 in GE1 cells."
reach
"For regulation of Amtn gene transcription by PgLPS via YY1 and Smad3, immunoprecipitation was carried out to examine whether YY1 and Smad3 binding responded independently or interactively to their own elements in the mouse Amtn gene promoter."
sparser
"YY1 interaction with Smad3 leads to the repression of miR-29 promoter during myoblasts transdifferentiation into myofibroblasts ( xref )."
reach
"Interestingly, physical interaction between YY1 and Smad3 was dramatically induced by PgLPS."
reach
"YY1 was co-immunoprecipitated with Smad3 and Smad4 (XREF_FIG), consistent with a previous study XREF_BIBR, suggesting that YY1 physically interacts with both Smad3 and Smad4."
reach
"In contrast, for the interaction between YY1 and Smad3, PgLPS increased YY1 binding to Smad3."
YY1 binds CEBPB and SMAD3. 7 / 7
| 7
sparser
"To further clarify the interaction between specific transcription factors, such as C/EBPβ, YY1 and Smad3, in the mouse Amtn gene promoter in vivo , chromatin immunoprecipitation assays (ChIP) assays were carried out."
sparser
"Hence, we proposed that Pg LPS increased Smad3 binding to C/EBPβ and YY1, and thereby upregulated Amtn gene transcription."
sparser
"Considering to the results of C/EBPβ, YY1, Smad3 and pSmad3 protein levels after stimulation by Pg LPS (Fig.  xref and Table 3), LPS‐induced C/EBPβ, YY1 and pSmad3 directly bind to C/EBP1, 2 and YY1 elements, respectively, mediating their physical interaction with Smad3."
sparser
"Furthermore, we identifiedLPS‐modulated interactions with C/EBPβ,YY1 and Smad3."
sparser
"Here, we report that Pg LPS‐induced physical interactions between C/EBPβ, YY1 and Smad3 upregulate Amtn gene transcription via mitogen‐activated protein kinase kinase 1/2 (MEK1/2), phosphatidylinositol 3‐kinase (PI3‐K) and Smad2/3 pathways in mouse gingival epithelial cells."
sparser
"C/EBPβ and YY1 directly interact with Smad3 in GE1 cells."
sparser
"In this study we have shown that Pg LPS induced Amtn gene transcription that was mediated through C/EBPβ, YY1 and Smad3 binding to C/EBP1, C/EBP2 and YY1 elements, which was accompanied by physical interaction between C/EBPβ, YY1 and Smad3."
YY1 binds SMAD3 and SMAD4. 1 / 1
| 1
sparser
"YY1 was co-immunoprecipitated with Smad3 and Smad4 ( xref ), consistent with a previous study xref , suggesting that YY1 physically interacts with both Smad3 and Smad4."
YY1 binds SMAD3, SMAD4, and CNS1. 1 / 1
| 1
sparser
"YY1 associates with Smad3 and Smad4 to block their binding to the Foxp3 CNS1, which is a crucial Smad-binding site for Foxp3 expression during T reg cell differentiation."
YY1 binds CEBPB, SMAD3, and SMAD3. 1 / 1
| 1
sparser
"We next investigated effects of Pg LPS on the protein levels of transcription factors, such as C/EBPβ, YY1, Smad3 and pSmad3 which bind to C/EBP1, C/EBP2 and YY1 elements in the mouse Amtn gene promotor."
CEBP binds YY1, CEBPB, and SMAD3. 1 / 1
| 1
sparser
"These results demonstrate that Pg LPS regulates Amtn gene transcription via binding of C/EBPβ-Smad3 and YY1-Smad3 complexes to C/EBP1, C/EBP2 and YY1 response elements in the mouse Amtn gene promoter."
NFY binds SP1, TP53, YY1, and SMAD3. 1 / 1
| 1
sparser
"Whether the interaction of Sp1, SMAD3, NF-Y and YY1 with p53 is dependent on cooperativity has so far not been explored."
YY1 binds SMAD2, SMAD3, SMAD4, and foxp3. 1 / 1
| 1
sparser
"YY1 was associated with Smad3 ( xref ), Smad4 ( xref ), Foxp3 ( xref ) and Smad2 ( xref )."
SMAD3 affects YY1
2 | 16 12
2 | 3 12
sparser
"Interestingly, physical interaction between YY1 and Smad3 was dramatically induced by Pg LPS (Fig.  xref B)."
biogrid
No evidence text available
reach
"Interestingly, Smad3 binding to C/EBP1, C/EBP2 and YY1 was increased by PgLPS in a time dependent manner."
reach
"C/EBPbeta and YY1 directly interact with Smad3 in GE1 cells."
reach
"For regulation of Amtn gene transcription by PgLPS via YY1 and Smad3, immunoprecipitation was carried out to examine whether YY1 and Smad3 binding responded independently or interactively to their own elements in the mouse Amtn gene promoter."
sparser
"YY1 interaction with Smad3 leads to the repression of miR-29 promoter during myoblasts transdifferentiation into myofibroblasts ( xref )."
reach
"Interestingly, physical interaction between YY1 and Smad3 was dramatically induced by PgLPS."
reach
"YY1 was co-immunoprecipitated with Smad3 and Smad4 (XREF_FIG), consistent with a previous study XREF_BIBR, suggesting that YY1 physically interacts with both Smad3 and Smad4."
reach
"In contrast, for the interaction between YY1 and Smad3, PgLPS increased YY1 binding to Smad3."
YY1 binds CEBPB and SMAD3. 7 / 7
| 7
sparser
"To further clarify the interaction between specific transcription factors, such as C/EBPβ, YY1 and Smad3, in the mouse Amtn gene promoter in vivo , chromatin immunoprecipitation assays (ChIP) assays were carried out."
sparser
"Hence, we proposed that Pg LPS increased Smad3 binding to C/EBPβ and YY1, and thereby upregulated Amtn gene transcription."
sparser
"Considering to the results of C/EBPβ, YY1, Smad3 and pSmad3 protein levels after stimulation by Pg LPS (Fig.  xref and Table 3), LPS‐induced C/EBPβ, YY1 and pSmad3 directly bind to C/EBP1, 2 and YY1 elements, respectively, mediating their physical interaction with Smad3."
sparser
"Furthermore, we identifiedLPS‐modulated interactions with C/EBPβ,YY1 and Smad3."
sparser
"Here, we report that Pg LPS‐induced physical interactions between C/EBPβ, YY1 and Smad3 upregulate Amtn gene transcription via mitogen‐activated protein kinase kinase 1/2 (MEK1/2), phosphatidylinositol 3‐kinase (PI3‐K) and Smad2/3 pathways in mouse gingival epithelial cells."
sparser
"C/EBPβ and YY1 directly interact with Smad3 in GE1 cells."
sparser
"In this study we have shown that Pg LPS induced Amtn gene transcription that was mediated through C/EBPβ, YY1 and Smad3 binding to C/EBP1, C/EBP2 and YY1 elements, which was accompanied by physical interaction between C/EBPβ, YY1 and Smad3."
YY1 binds SMAD3 and SMAD4. 1 / 1
| 1
sparser
"YY1 was co-immunoprecipitated with Smad3 and Smad4 ( xref ), consistent with a previous study xref , suggesting that YY1 physically interacts with both Smad3 and Smad4."
YY1 binds SMAD3, SMAD4, and CNS1. 1 / 1
| 1
sparser
"YY1 associates with Smad3 and Smad4 to block their binding to the Foxp3 CNS1, which is a crucial Smad-binding site for Foxp3 expression during T reg cell differentiation."
YY1 binds CEBPB, SMAD3, and SMAD3. 1 / 1
| 1
sparser
"We next investigated effects of Pg LPS on the protein levels of transcription factors, such as C/EBPβ, YY1, Smad3 and pSmad3 which bind to C/EBP1, C/EBP2 and YY1 elements in the mouse Amtn gene promotor."
CEBP binds YY1, CEBPB, and SMAD3. 1 / 1
| 1
sparser
"These results demonstrate that Pg LPS regulates Amtn gene transcription via binding of C/EBPβ-Smad3 and YY1-Smad3 complexes to C/EBP1, C/EBP2 and YY1 response elements in the mouse Amtn gene promoter."
NFY binds SP1, TP53, YY1, and SMAD3. 1 / 1
| 1
sparser
"Whether the interaction of Sp1, SMAD3, NF-Y and YY1 with p53 is dependent on cooperativity has so far not been explored."
YY1 binds SMAD2, SMAD3, SMAD4, and foxp3. 1 / 1
| 1
sparser
"YY1 was associated with Smad3 ( xref ), Smad4 ( xref ), Foxp3 ( xref ) and Smad2 ( xref )."
CEBPB affects SMAD3, and YY1
| 8
YY1 binds CEBPB and SMAD3. 7 / 7
| 7
sparser
"To further clarify the interaction between specific transcription factors, such as C/EBPβ, YY1 and Smad3, in the mouse Amtn gene promoter in vivo , chromatin immunoprecipitation assays (ChIP) assays were carried out."
sparser
"Hence, we proposed that Pg LPS increased Smad3 binding to C/EBPβ and YY1, and thereby upregulated Amtn gene transcription."
sparser
"Considering to the results of C/EBPβ, YY1, Smad3 and pSmad3 protein levels after stimulation by Pg LPS (Fig.  xref and Table 3), LPS‐induced C/EBPβ, YY1 and pSmad3 directly bind to C/EBP1, 2 and YY1 elements, respectively, mediating their physical interaction with Smad3."
sparser
"Furthermore, we identifiedLPS‐modulated interactions with C/EBPβ,YY1 and Smad3."
sparser
"Here, we report that Pg LPS‐induced physical interactions between C/EBPβ, YY1 and Smad3 upregulate Amtn gene transcription via mitogen‐activated protein kinase kinase 1/2 (MEK1/2), phosphatidylinositol 3‐kinase (PI3‐K) and Smad2/3 pathways in mouse gingival epithelial cells."
sparser
"C/EBPβ and YY1 directly interact with Smad3 in GE1 cells."
sparser
"In this study we have shown that Pg LPS induced Amtn gene transcription that was mediated through C/EBPβ, YY1 and Smad3 binding to C/EBP1, C/EBP2 and YY1 elements, which was accompanied by physical interaction between C/EBPβ, YY1 and Smad3."
YY1 binds CEBPB, SMAD3, and SMAD3. 1 / 1
| 1
sparser
"We next investigated effects of Pg LPS on the protein levels of transcription factors, such as C/EBPβ, YY1, Smad3 and pSmad3 which bind to C/EBP1, C/EBP2 and YY1 elements in the mouse Amtn gene promotor."
SMAD3 affects SMAD4, and YY1
| 1
YY1 binds SMAD3 and SMAD4. 1 / 1
| 1
sparser
"YY1 was co-immunoprecipitated with Smad3 and Smad4 ( xref ), consistent with a previous study xref , suggesting that YY1 physically interacts with both Smad3 and Smad4."
SMAD2 affects SMAD3, SMAD4, YY1, and foxp3
| 1
YY1 binds SMAD2, SMAD3, SMAD4, and foxp3. 1 / 1
| 1
sparser
"YY1 was associated with Smad3 ( xref ), Smad4 ( xref ), Foxp3 ( xref ) and Smad2 ( xref )."
NFY affects SMAD3, SP1, TP53, and YY1
| 1
NFY binds SP1, TP53, YY1, and SMAD3. 1 / 1
| 1
sparser
"Whether the interaction of Sp1, SMAD3, NF-Y and YY1 with p53 is dependent on cooperativity has so far not been explored."
CNS1 affects SMAD3, SMAD4, and YY1
| 1
YY1 binds SMAD3, SMAD4, and CNS1. 1 / 1
| 1
sparser
"YY1 associates with Smad3 and Smad4 to block their binding to the Foxp3 CNS1, which is a crucial Smad-binding site for Foxp3 expression during T reg cell differentiation."
CHUK affects HIF1A, JNK, NOTCH1, SMAD3, and YY1
| 1
| 1
sparser
"It has been reported that NICD could associate with NFκB, IKKα, Smad3, HIF-1α, YY1, and JNK, although the conditions for these associations have not been well characterized [ xref , xref , xref ]."
CEBP affects CEBPB, SMAD3, and YY1
| 1
CEBP binds YY1, CEBPB, and SMAD3. 1 / 1
| 1
sparser
"These results demonstrate that Pg LPS regulates Amtn gene transcription via binding of C/EBPβ-Smad3 and YY1-Smad3 complexes to C/EBP1, C/EBP2 and YY1 response elements in the mouse Amtn gene promoter."