IndraLab

Statements

SPOP binds NANOG. 10 / 32
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sparser
"Moreover, SPOP specifically interacted with Nanog both in vitro and in cells ( xref – xref ) but not with other stem cell determining factors such as Oct4, Sox2, and Klf4 in cells ( xref )."
30595538
sparser
"The cancer-associated NANOG S68Y mutant is refractory for SPOP-mediated degradation since NANOG Ser68 is required for the direct interaction between SPOP and NANOG."
30595535
reach
"Co-immunoprecipitation experiments in SW1990 cells showed that SPOP interacted with the stem-cell marker NANOG, and this interaction has recently been shown to play a critical role in regulating progression of prostate cancer."
31624231
reach
"In addition, SPOP mediated NANOG degradation is controlled by the AMPK-BRAF signal axis through the phosphorylation of NANOG at Ser68, which blocked the interaction between SPOP and NANOG."
30595535
sparser
"However, the cancer-associated mutation 66 PDYST 70 in the NANOG mutant increased steric hindrance and impaired its interaction with SPOP ( xref ), suggesting that the cancer-associated mutant S68Y may affect the interaction between NANOG and SPOP."
30595535
sparser
"Importantly, deleting the putative motif 66PDSST 70 (ΔPDSST) impaired the interaction between Nanog and SPOP both in cells and in vitro ( xref , xref , and xref ), leading to acquired resistance to SPOP-mediated destruction ( xref – xref ) and poly-ubiquitination in cells and in vitro ( xref and xref )."
30595538
sparser
"Clinically, cancer-associated mutations in the MATH domain of SPOP disrupt the interaction between SPOP and NANOG, thereby preventing SPOP-mediated destruction of NANOG, stabilizing NANOG from AMPK-BRAF-signaling-axis-induced phosphorylation, and consequently promoting the maintenance of PCa stem-like cells."
30595535
sparser
"Notably, we observed that deletion of the MATH domain could disrupt SPOP interaction with Nanog and abrogate SPOP-mediated Nanog destruction ( xref and xref )."
30595538
sparser
"Our data indicated that SPOP specifically interacts with NANOG, but not other stem cell transcriptional factors, including OCT4, SOX2, and KLF4 ( xref )."
30595535
sparser
"Co-immunoprecipitation experiments in SW1990 cells showed that SPOP interacted with the stem-cell marker NANOG, and this interaction has recently been shown to play a critical role in regulating progression of prostate cancer."
31624231