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IndraLab

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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RHEB affects MTOR
2 10 4 | 3 162 75
2 10 4 | 3 120 69
sparser
"However no connection between mTORC1 signaling and ASM inhibition was made in this previous report, and our data indicates that siramesine in nutrient-replete conditions cannot break the mTOR-Rheb interaction in the same manner as DQ661."
sparser
"Since it remained possible that FTS may disrupt Rheb interaction with mTOR, we next asked if FTS inhibits Rheb-induced activation of mTOR."
reach
"While CHAPS can retain the interaction of Rheb and mTOR, NP40 disrupts the interaction."
sparser
"Rheb binds directly to the mTOR catalytic domain, and Rheb-GTP enables TORC1 to attain an active configuration."
sparser
"Herein we show that the binding of Rheb to endogenous and recombinant mTOR is reversibly inhibited by withdrawal of all extracellular amino acids or just leucine."
reach
"Rheb interacts directly with mTOR and activates mTOR kinase, whereas Rabin8 interacts with Rheb and inhibits the phosphorylation of Ser235 and Ser236 in small ribosomal subunit protein S6."
reach
"The average excited state lifetime of the EGFP-mTOR in the presence of DsRed-Rheb was determined to be 2200 +/- 50 ps in three independent experiments, the reduced level due to a direct interaction between Rheb and mTOR, due to energy transfer from EGFP to DsRed."
sparser
"Meanwhile, the interaction between Rheb and mTOR was abrogated, which agrees with previously published data [ xref ]."
sparser
"Similarly, while neither baf nor the LMP-inducer siramesine disrupted the mTOR-Rheb interaction, which is critical for mTORC1 growth signaling, this interaction was completely disrupted by DQ661 ( xref )."
RHEB binds FKBP8 and MTOR. 6 / 6
| 6
sparser
"The presence of growth factors and amino acids promotes accumulation of GTP-bound Rheb, which interacts with FKBP38 and releases mTOR from its inhibition [ xref ] ( xref )."
sparser
"While in conditions of rich growth factors and nutrients, FKBP_C domain may interact with Rheb (Ras homolog enriched in brain)-GTP to activate the mTOR downstream signaling pathway by releasing mTOR from FKBP38 ( xref )."
sparser
"Under conditions of ample growth factors and nutrients, the FKBP_C domain might interact with Rheb-GTP to activate downstream mTOR signaling by releasing mTOR from FKBP38 and the Switch I domain of the Rheb-mediated interaction with FKBP_C. Rheb, FKBP38, and mTOR coexist on mitochondria, and their interaction might depend on their localization in living cells ( xref )."
sparser
"Taking this into consideration, the effects of PRL-3 on FKBP38-mTOR and FKBP38-Rheb-GTP interaction are currently under investigation."
sparser
"However, the interactions of Rheb and mTOR with FKBP38 do not appear to be mutually exclusive."
sparser
"A dominant inactive mutant of Rheb is able to bind with FKBP38 without dissociating mTOR, indicating that Rheb regulates FKBP38 allosterically in a GTP-dependent manner and consequently alters its interaction with mTOR [ xref ]."
RHEB binds RRAGB, MTOR, and MADS3. 4 / 4
| 4
sparser
"PA decreases AMPK/ TSC2 phosphorylation and increases mTOR binding with Rheb and Rag GTPases."
sparser
"In contrast, PA appeared to regulate mTORC1 via changes in the interactions of mTOR with Rheb and Rag GTPase."
sparser
"TSC2 then inactivates Rheb, which impairs the interaction of mTOR with Rheb and Rag proteins."
sparser
"The addition of PA to myocytes increased mTORC1-dependent S6K1 phosphorylation, and this was associated with increased binding of mTOR with Rheb and Rag GTPase."
RHEB binds MTOR and TOR. 3 / 3
| 3
sparser
"Amino acid withdrawal may generate an inhibitor of the Rheb-mTOR interaction that interferes with the signaling function of TOR complex 1."
sparser
"Activated Rheb binds and activates the mTOR kinase, constitutively driving the TOR pathway [ xref , xref ]."
sparser
"Activated Rheb binds and activates the mTOR kinase to constitutively drive the TOR pathway [ xref , xref ]."
sparser
"Although difficult to assess quantitatively, the efficiency with which recombinant Rheb associates with HA-mTOR in vivo or in vitro appears to be low."
sparser
"Thus, although the nucleotide-deficient Rheb mutants bind HA-mTOR more tightly than does wild-type Rheb, the HA-mTOR polypeptides bound to these mutants are unable to acquire kinase activity during tr[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"We infer that HA-mTORs bound to wild-type Rheb reflect a mixture of HA-mTORs bound to Rheb-GTP, which have high kinase activity, and (given the 40%–50% GDP charging we observe for wild-type Rheb) a co[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
RHEB binds MTOR and GAPDH. 3 / 3
| 3
sparser
"GAPDH interaction with rheb, the activator of mTOR, mitigates mTOR-C1 signaling pathway thus halting the growth mechanism under conditions of energy depletion or inadequate glycolysis."
sparser
"We explored the impact of GAPDH-Rheb binding upon mTOR signaling."
sparser
"Our co-immunoprecipitation experiments showed that this was not the mechanism for fructose-induced mTORC1 activation, since Rheb-GAPDH and Rheb-mTOR interactions were not affected in the livers of fructose-supplemented rats [ xref ]."
Mutated RHEB binds MTOR. 2 / 2
| 2
reach
"Moreover, the binding of mTOR to Rheb mutants that are unable to bind guanyl nucleotide in vivo is also inhibited by amino withdrawal."
reach
"It has been shown that Rheb mutants devoid of nucleotide binding associate more strongly with mTOR than wild-type or active Rheb."
C1 binds RHEB and MTOR. 2 / 2
| 1 1
reach
"This causes, release of TSC2 bound Rheb (Ras homolog enriched in brain) which then bind to the mTOR 1 complex causing mTOR C1 activation and phosphorylation of its downstream effectors [XREF_BIBR]."
sparser
"This causes, release of TSC2-bound Rheb (Ras homolog enriched in brain) which then bind to the mTOR 1 complex causing mTOR C1 activation and phosphorylation of its downstream effectors [ xref ]."
RHEB binds STAT6 and MTOR. 2 / 2
| 2
sparser
"To further examine the effects of STAT6 on Rheb-mTOR binding, we analyzed the interactions of STAT6 with Rheb or mTOR."
sparser
"STAT6 interacts directly with Rheb, leading to mTOR inhibition."
RHEB binds RPTOR and MTOR. 2 / 2
| 2
sparser
"Whether TSC1/2 and/or Rheb binds to the mTOR complex containing raptor and modulates the signaling function and kinase activity of mTOR remains an important but unanswered question."
sparser
"In addition to directly phosphorylating mTOR, AKT also phosphorylates TSC2, which results in a Rheb-mediated interaction between mTOR and Raptor (regulatory associated protein of mTOR) to create mTOR complex 1 (mTORC1)."
RHEB binds BNIP3L and MTOR. 1 / 1
| 1
sparser
"By contrast, the interaction of NIX with Rheb elicited mTOR- independent effects on cell growth [ xref ]."
RHEB binds RPS6 and MTOR. 1 / 1
| 1
sparser
"A constitutively active form of RHEB, RHEB-Q64L, which stimulates S6 phosphorylation through the activation of MTOR signaling, was transfected into U2OS cells to recover MTOR activity."
RHEB binds MTOR and RALB. 1 / 1
| 1
sparser
"Consistent with Rheb and RalB interacting with the same region of mTOR, we found that RalB could successfully compete with Rheb for mTOR binding ( xref )."
MTORC1 binds RHEB and MTOR. 1 / 1
| 1
sparser
"In agreement with this idea, the increased binding of TSC to Rheb is at the expense of the interaction between Rheb and mTOR ( xref ), which would render mTORC1 inactive and explain severe inhibition of its activity seen in complete starvation conditions."
RHEB binds TSC2 and MTOR. 1 / 1
| 1
sparser
"The gene product of PKD1 , polycystin-1, interacts with TSC2, which forms a complex with the GTP-binding protein RHEB upstream of mTOR."
RHEB binds MTOR and RAB5A. 1 / 1
| 1
sparser
"Both Rab5 and Rheb interact in the mTOR pathway [ xref , xref ]."
RHEB binds RRAGC and MTOR. 1 / 1
| 1
sparser
"This resulted in increased Rheb and RagA/ RagC GTPase interactions with mTOR, as well as suppression of mTORC2."
RHEB binds RAB3IP and MTOR. 1 / 1
| 1
sparser
"We studied the possibility of interaction between Rabin8, Rheb, and mTOR using transfection in HEK293 by simultaneous transfection of pcDNA3.1 and pCMVTag3A control vectors ( xref А, lane 1) or two vectors expressing Rabin8 and Myc-Rheb fusion protein ( xref А, lanes 2– 4 ) in a medium with ( xref A, lanes 1 and 2) or without growth factors ( xref A, lane 3), as well as after short-term stimulation of the cells grown for 24 hr without growth factors ( xref А, lane 4)."
GST binds RHEB and MTOR. 1 / 1
| 1
sparser
"Notably, the inactive Rheb switch 1 mutant Thr38Met binds endogenous mTOR in a manner equivalent to wild-type GST-Rheb, whereas mTOR binding to Rheb Ile39Lys and to GST-Rheb Gln64Leu is reduced as com[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
RHEB binds MTOR and LAMP1. 1 / 1
| 1
sparser
"The availability of amino acids stimulates the translocation of mTORC1 to the lysosomal surface, where it associates with Rheb resulting in activation of mTOR kinase [ xref , xref ]."
RHEB binds MTOR and htt. 1 / 1
| 1
sparser
"Pull-down experiments indicated that amino acids stimulated the interaction of Htt and the guanosine triphosphatase (GTPase) Rheb (a protein that stimulates mTOR activity), and that Htt forms a ternary complex with Rheb and mTOR."
RHEB binds MTOR and PYD1. 1 / 1
| 1
sparser
"This may be due to reduction in AMP-activated protein kinase signaling [ xref ] or due to the decreased interaction of glyceraldehyde 3-phosphate dehydrogenase and Rheb [ xref ], each of which would promote mTOR activation (specifically, the mTORC1 complex) by the small GTPase Rheb ( xref )."
RHEB binds CD36 and MTOR. 1 / 1
| 1
sparser
"A cryo-EM structure of Rheb bound to mTORC1 revealed that the Switch II region of Rheb interacts with the mTOR N-heat, M-heat, and FAT domains."
RHEB binds MTOR and leucine. 1 / 1
| 1
reach
"Thus, there may be one or more Rag, Ragulator, and/or endosomal mechanisms by which sepsis disturbs the interaction of mTOR and Rheb culminating in leucine resistance."
RHEB binds TSC1, TSC2, and MTOR. 1 / 1
| 1
sparser
"Full-length TSC2 protein interacts with TSC1 to inhibit the activation of mTOR by Rheb."
sparser
"Somewhat lesser amounts of HA-mTOR polypeptide are recovered with GST-Rheb(Gln64Leu) as compared with wild-type GST-Rheb ( Figure 7 B); however, when comparable amounts of Rheb bound HA-mTOR polypepti[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
| 1
sparser
"Moreover, changes in mTORC1 activity correlated directly with altered association of mTOR with RagB/RagC, Rheb, raptor, and PRAS40."
RHEB binds RRAGA, RRAGC, and MTOR. 1 / 1
| 1
sparser
"In LD, eIF4E∙eIF4G complex formation, phosphorylation of TSC2, mTOR, and rpS6, and association of mTOR with RagA, RagC, and Rheb were increased by feeding and blunted by prematurity."
TSC binds RHEB, MTOR, and TBC. 1 / 1
| 1
reach
"The mTOR, Rheb, TSC, and TBC complex co and localizes to the lysosome and the phosphorylation of TSC-TBC effects the dissociation of the complex from the lysosome and activates Rheb."
MTORC1 binds RHEB, RPTOR, and MTOR. 1 / 1
| 1
sparser
"The interaction of the mTORC1 components Rheb, mTOR and raptor, tagged with EGFP/DsRed was determined using fluorescence energy transfer-FLIM."
RHEB binds TSC2, ENPP1, and MTOR. 1 / 1
| 1
reach
"Also a PC1, Tuberin, Rheb, and mTOR complex model is proposed to illustrate the role of Tuberin in mTOR signaling pathway 40."
MTOR affects RHEB
2 10 4 | 3 162 75
2 10 4 | 3 120 69
sparser
"However no connection between mTORC1 signaling and ASM inhibition was made in this previous report, and our data indicates that siramesine in nutrient-replete conditions cannot break the mTOR-Rheb interaction in the same manner as DQ661."
sparser
"Since it remained possible that FTS may disrupt Rheb interaction with mTOR, we next asked if FTS inhibits Rheb-induced activation of mTOR."
reach
"While CHAPS can retain the interaction of Rheb and mTOR, NP40 disrupts the interaction."
sparser
"Rheb binds directly to the mTOR catalytic domain, and Rheb-GTP enables TORC1 to attain an active configuration."
sparser
"Herein we show that the binding of Rheb to endogenous and recombinant mTOR is reversibly inhibited by withdrawal of all extracellular amino acids or just leucine."
reach
"Rheb interacts directly with mTOR and activates mTOR kinase, whereas Rabin8 interacts with Rheb and inhibits the phosphorylation of Ser235 and Ser236 in small ribosomal subunit protein S6."
reach
"The average excited state lifetime of the EGFP-mTOR in the presence of DsRed-Rheb was determined to be 2200 +/- 50 ps in three independent experiments, the reduced level due to a direct interaction between Rheb and mTOR, due to energy transfer from EGFP to DsRed."
sparser
"Meanwhile, the interaction between Rheb and mTOR was abrogated, which agrees with previously published data [ xref ]."
sparser
"Similarly, while neither baf nor the LMP-inducer siramesine disrupted the mTOR-Rheb interaction, which is critical for mTORC1 growth signaling, this interaction was completely disrupted by DQ661 ( xref )."
RHEB binds FKBP8 and MTOR. 6 / 6
| 6
sparser
"The presence of growth factors and amino acids promotes accumulation of GTP-bound Rheb, which interacts with FKBP38 and releases mTOR from its inhibition [ xref ] ( xref )."
sparser
"While in conditions of rich growth factors and nutrients, FKBP_C domain may interact with Rheb (Ras homolog enriched in brain)-GTP to activate the mTOR downstream signaling pathway by releasing mTOR from FKBP38 ( xref )."
sparser
"Under conditions of ample growth factors and nutrients, the FKBP_C domain might interact with Rheb-GTP to activate downstream mTOR signaling by releasing mTOR from FKBP38 and the Switch I domain of the Rheb-mediated interaction with FKBP_C. Rheb, FKBP38, and mTOR coexist on mitochondria, and their interaction might depend on their localization in living cells ( xref )."
sparser
"Taking this into consideration, the effects of PRL-3 on FKBP38-mTOR and FKBP38-Rheb-GTP interaction are currently under investigation."
sparser
"However, the interactions of Rheb and mTOR with FKBP38 do not appear to be mutually exclusive."
sparser
"A dominant inactive mutant of Rheb is able to bind with FKBP38 without dissociating mTOR, indicating that Rheb regulates FKBP38 allosterically in a GTP-dependent manner and consequently alters its interaction with mTOR [ xref ]."
RHEB binds RRAGB, MTOR, and MADS3. 4 / 4
| 4
sparser
"PA decreases AMPK/ TSC2 phosphorylation and increases mTOR binding with Rheb and Rag GTPases."
sparser
"In contrast, PA appeared to regulate mTORC1 via changes in the interactions of mTOR with Rheb and Rag GTPase."
sparser
"TSC2 then inactivates Rheb, which impairs the interaction of mTOR with Rheb and Rag proteins."
sparser
"The addition of PA to myocytes increased mTORC1-dependent S6K1 phosphorylation, and this was associated with increased binding of mTOR with Rheb and Rag GTPase."
RHEB binds MTOR and TOR. 3 / 3
| 3
sparser
"Amino acid withdrawal may generate an inhibitor of the Rheb-mTOR interaction that interferes with the signaling function of TOR complex 1."
sparser
"Activated Rheb binds and activates the mTOR kinase, constitutively driving the TOR pathway [ xref , xref ]."
sparser
"Activated Rheb binds and activates the mTOR kinase to constitutively drive the TOR pathway [ xref , xref ]."
sparser
"Although difficult to assess quantitatively, the efficiency with which recombinant Rheb associates with HA-mTOR in vivo or in vitro appears to be low."
sparser
"Thus, although the nucleotide-deficient Rheb mutants bind HA-mTOR more tightly than does wild-type Rheb, the HA-mTOR polypeptides bound to these mutants are unable to acquire kinase activity during tr[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"We infer that HA-mTORs bound to wild-type Rheb reflect a mixture of HA-mTORs bound to Rheb-GTP, which have high kinase activity, and (given the 40%–50% GDP charging we observe for wild-type Rheb) a co[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
RHEB binds MTOR and GAPDH. 3 / 3
| 3
sparser
"GAPDH interaction with rheb, the activator of mTOR, mitigates mTOR-C1 signaling pathway thus halting the growth mechanism under conditions of energy depletion or inadequate glycolysis."
sparser
"We explored the impact of GAPDH-Rheb binding upon mTOR signaling."
sparser
"Our co-immunoprecipitation experiments showed that this was not the mechanism for fructose-induced mTORC1 activation, since Rheb-GAPDH and Rheb-mTOR interactions were not affected in the livers of fructose-supplemented rats [ xref ]."
Mutated RHEB binds MTOR. 2 / 2
| 2
reach
"Moreover, the binding of mTOR to Rheb mutants that are unable to bind guanyl nucleotide in vivo is also inhibited by amino withdrawal."
reach
"It has been shown that Rheb mutants devoid of nucleotide binding associate more strongly with mTOR than wild-type or active Rheb."
C1 binds RHEB and MTOR. 2 / 2
| 1 1
reach
"This causes, release of TSC2 bound Rheb (Ras homolog enriched in brain) which then bind to the mTOR 1 complex causing mTOR C1 activation and phosphorylation of its downstream effectors [XREF_BIBR]."
sparser
"This causes, release of TSC2-bound Rheb (Ras homolog enriched in brain) which then bind to the mTOR 1 complex causing mTOR C1 activation and phosphorylation of its downstream effectors [ xref ]."
RHEB binds STAT6 and MTOR. 2 / 2
| 2
sparser
"To further examine the effects of STAT6 on Rheb-mTOR binding, we analyzed the interactions of STAT6 with Rheb or mTOR."
sparser
"STAT6 interacts directly with Rheb, leading to mTOR inhibition."
RHEB binds RPTOR and MTOR. 2 / 2
| 2
sparser
"Whether TSC1/2 and/or Rheb binds to the mTOR complex containing raptor and modulates the signaling function and kinase activity of mTOR remains an important but unanswered question."
sparser
"In addition to directly phosphorylating mTOR, AKT also phosphorylates TSC2, which results in a Rheb-mediated interaction between mTOR and Raptor (regulatory associated protein of mTOR) to create mTOR complex 1 (mTORC1)."
RHEB binds BNIP3L and MTOR. 1 / 1
| 1
sparser
"By contrast, the interaction of NIX with Rheb elicited mTOR- independent effects on cell growth [ xref ]."
RHEB binds RPS6 and MTOR. 1 / 1
| 1
sparser
"A constitutively active form of RHEB, RHEB-Q64L, which stimulates S6 phosphorylation through the activation of MTOR signaling, was transfected into U2OS cells to recover MTOR activity."
RHEB binds MTOR and RALB. 1 / 1
| 1
sparser
"Consistent with Rheb and RalB interacting with the same region of mTOR, we found that RalB could successfully compete with Rheb for mTOR binding ( xref )."
MTORC1 binds RHEB and MTOR. 1 / 1
| 1
sparser
"In agreement with this idea, the increased binding of TSC to Rheb is at the expense of the interaction between Rheb and mTOR ( xref ), which would render mTORC1 inactive and explain severe inhibition of its activity seen in complete starvation conditions."
RHEB binds TSC2 and MTOR. 1 / 1
| 1
sparser
"The gene product of PKD1 , polycystin-1, interacts with TSC2, which forms a complex with the GTP-binding protein RHEB upstream of mTOR."
RHEB binds MTOR and RAB5A. 1 / 1
| 1
sparser
"Both Rab5 and Rheb interact in the mTOR pathway [ xref , xref ]."
RHEB binds RRAGC and MTOR. 1 / 1
| 1
sparser
"This resulted in increased Rheb and RagA/ RagC GTPase interactions with mTOR, as well as suppression of mTORC2."
RHEB binds RAB3IP and MTOR. 1 / 1
| 1
sparser
"We studied the possibility of interaction between Rabin8, Rheb, and mTOR using transfection in HEK293 by simultaneous transfection of pcDNA3.1 and pCMVTag3A control vectors ( xref А, lane 1) or two vectors expressing Rabin8 and Myc-Rheb fusion protein ( xref А, lanes 2– 4 ) in a medium with ( xref A, lanes 1 and 2) or without growth factors ( xref A, lane 3), as well as after short-term stimulation of the cells grown for 24 hr without growth factors ( xref А, lane 4)."
GST binds RHEB and MTOR. 1 / 1
| 1
sparser
"Notably, the inactive Rheb switch 1 mutant Thr38Met binds endogenous mTOR in a manner equivalent to wild-type GST-Rheb, whereas mTOR binding to Rheb Ile39Lys and to GST-Rheb Gln64Leu is reduced as com[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
RHEB binds MTOR and LAMP1. 1 / 1
| 1
sparser
"The availability of amino acids stimulates the translocation of mTORC1 to the lysosomal surface, where it associates with Rheb resulting in activation of mTOR kinase [ xref , xref ]."
RHEB binds MTOR and htt. 1 / 1
| 1
sparser
"Pull-down experiments indicated that amino acids stimulated the interaction of Htt and the guanosine triphosphatase (GTPase) Rheb (a protein that stimulates mTOR activity), and that Htt forms a ternary complex with Rheb and mTOR."
RHEB binds MTOR and PYD1. 1 / 1
| 1
sparser
"This may be due to reduction in AMP-activated protein kinase signaling [ xref ] or due to the decreased interaction of glyceraldehyde 3-phosphate dehydrogenase and Rheb [ xref ], each of which would promote mTOR activation (specifically, the mTORC1 complex) by the small GTPase Rheb ( xref )."
RHEB binds CD36 and MTOR. 1 / 1
| 1
sparser
"A cryo-EM structure of Rheb bound to mTORC1 revealed that the Switch II region of Rheb interacts with the mTOR N-heat, M-heat, and FAT domains."
RHEB binds MTOR and leucine. 1 / 1
| 1
reach
"Thus, there may be one or more Rag, Ragulator, and/or endosomal mechanisms by which sepsis disturbs the interaction of mTOR and Rheb culminating in leucine resistance."
RHEB binds TSC1, TSC2, and MTOR. 1 / 1
| 1
sparser
"Full-length TSC2 protein interacts with TSC1 to inhibit the activation of mTOR by Rheb."
sparser
"Somewhat lesser amounts of HA-mTOR polypeptide are recovered with GST-Rheb(Gln64Leu) as compared with wild-type GST-Rheb ( Figure 7 B); however, when comparable amounts of Rheb bound HA-mTOR polypepti[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
| 1
sparser
"Moreover, changes in mTORC1 activity correlated directly with altered association of mTOR with RagB/RagC, Rheb, raptor, and PRAS40."
RHEB binds RRAGA, RRAGC, and MTOR. 1 / 1
| 1
sparser
"In LD, eIF4E∙eIF4G complex formation, phosphorylation of TSC2, mTOR, and rpS6, and association of mTOR with RagA, RagC, and Rheb were increased by feeding and blunted by prematurity."
TSC binds RHEB, MTOR, and TBC. 1 / 1
| 1
reach
"The mTOR, Rheb, TSC, and TBC complex co and localizes to the lysosome and the phosphorylation of TSC-TBC effects the dissociation of the complex from the lysosome and activates Rheb."
MTORC1 binds RHEB, RPTOR, and MTOR. 1 / 1
| 1
sparser
"The interaction of the mTORC1 components Rheb, mTOR and raptor, tagged with EGFP/DsRed was determined using fluorescence energy transfer-FLIM."
RHEB binds TSC2, ENPP1, and MTOR. 1 / 1
| 1
reach
"Also a PC1, Tuberin, Rheb, and mTOR complex model is proposed to illustrate the role of Tuberin in mTOR signaling pathway 40."
FKBP8 affects MTOR, and RHEB
| 6
RHEB binds FKBP8 and MTOR. 6 / 6
| 6
sparser
"The presence of growth factors and amino acids promotes accumulation of GTP-bound Rheb, which interacts with FKBP38 and releases mTOR from its inhibition [ xref ] ( xref )."
sparser
"While in conditions of rich growth factors and nutrients, FKBP_C domain may interact with Rheb (Ras homolog enriched in brain)-GTP to activate the mTOR downstream signaling pathway by releasing mTOR from FKBP38 ( xref )."
sparser
"Under conditions of ample growth factors and nutrients, the FKBP_C domain might interact with Rheb-GTP to activate downstream mTOR signaling by releasing mTOR from FKBP38 and the Switch I domain of the Rheb-mediated interaction with FKBP_C. Rheb, FKBP38, and mTOR coexist on mitochondria, and their interaction might depend on their localization in living cells ( xref )."
sparser
"Taking this into consideration, the effects of PRL-3 on FKBP38-mTOR and FKBP38-Rheb-GTP interaction are currently under investigation."
sparser
"However, the interactions of Rheb and mTOR with FKBP38 do not appear to be mutually exclusive."
sparser
"A dominant inactive mutant of Rheb is able to bind with FKBP38 without dissociating mTOR, indicating that Rheb regulates FKBP38 allosterically in a GTP-dependent manner and consequently alters its interaction with mTOR [ xref ]."
MADS3 affects MTOR, RHEB, and RRAGB
| 4
RHEB binds RRAGB, MTOR, and MADS3. 4 / 4
| 4
sparser
"PA decreases AMPK/ TSC2 phosphorylation and increases mTOR binding with Rheb and Rag GTPases."
sparser
"In contrast, PA appeared to regulate mTORC1 via changes in the interactions of mTOR with Rheb and Rag GTPase."
sparser
"TSC2 then inactivates Rheb, which impairs the interaction of mTOR with Rheb and Rag proteins."
sparser
"The addition of PA to myocytes increased mTORC1-dependent S6K1 phosphorylation, and this was associated with increased binding of mTOR with Rheb and Rag GTPase."
MTOR affects RHEB, and TOR
| 3
RHEB binds MTOR and TOR. 3 / 3
| 3
sparser
"Amino acid withdrawal may generate an inhibitor of the Rheb-mTOR interaction that interferes with the signaling function of TOR complex 1."
sparser
"Activated Rheb binds and activates the mTOR kinase, constitutively driving the TOR pathway [ xref , xref ]."
sparser
"Activated Rheb binds and activates the mTOR kinase to constitutively drive the TOR pathway [ xref , xref ]."
Hemagglutinins affects MTOR, and RHEB
| 3
sparser
"Although difficult to assess quantitatively, the efficiency with which recombinant Rheb associates with HA-mTOR in vivo or in vitro appears to be low."
sparser
"Thus, although the nucleotide-deficient Rheb mutants bind HA-mTOR more tightly than does wild-type Rheb, the HA-mTOR polypeptides bound to these mutants are unable to acquire kinase activity during tr[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"We infer that HA-mTORs bound to wild-type Rheb reflect a mixture of HA-mTORs bound to Rheb-GTP, which have high kinase activity, and (given the 40%–50% GDP charging we observe for wild-type Rheb) a co[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
GAPDH affects MTOR, and RHEB
| 3
RHEB binds MTOR and GAPDH. 3 / 3
| 3
sparser
"GAPDH interaction with rheb, the activator of mTOR, mitigates mTOR-C1 signaling pathway thus halting the growth mechanism under conditions of energy depletion or inadequate glycolysis."
sparser
"We explored the impact of GAPDH-Rheb binding upon mTOR signaling."
sparser
"Our co-immunoprecipitation experiments showed that this was not the mechanism for fructose-induced mTORC1 activation, since Rheb-GAPDH and Rheb-mTOR interactions were not affected in the livers of fructose-supplemented rats [ xref ]."
MTOR affects RHEB, and STAT6
| 2
RHEB binds STAT6 and MTOR. 2 / 2
| 2
sparser
"To further examine the effects of STAT6 on Rheb-mTOR binding, we analyzed the interactions of STAT6 with Rheb or mTOR."
sparser
"STAT6 interacts directly with Rheb, leading to mTOR inhibition."
MTOR affects RHEB, and RPTOR
| 2
RHEB binds RPTOR and MTOR. 2 / 2
| 2
sparser
"Whether TSC1/2 and/or Rheb binds to the mTOR complex containing raptor and modulates the signaling function and kinase activity of mTOR remains an important but unanswered question."
sparser
"In addition to directly phosphorylating mTOR, AKT also phosphorylates TSC2, which results in a Rheb-mediated interaction between mTOR and Raptor (regulatory associated protein of mTOR) to create mTOR complex 1 (mTORC1)."
C1 affects MTOR, and RHEB
| 1 1
C1 binds RHEB and MTOR. 2 / 2
| 1 1
reach
"This causes, release of TSC2 bound Rheb (Ras homolog enriched in brain) which then bind to the mTOR 1 complex causing mTOR C1 activation and phosphorylation of its downstream effectors [XREF_BIBR]."
sparser
"This causes, release of TSC2-bound Rheb (Ras homolog enriched in brain) which then bind to the mTOR 1 complex causing mTOR C1 activation and phosphorylation of its downstream effectors [ xref ]."
MTOR affects RHEB, and mTORC1
| 1
MTORC1 binds RHEB and MTOR. 1 / 1
| 1
sparser
"In agreement with this idea, the increased binding of TSC to Rheb is at the expense of the interaction between Rheb and mTOR ( xref ), which would render mTORC1 inactive and explain severe inhibition of its activity seen in complete starvation conditions."
MTOR affects RHEB, and leucine
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RHEB binds MTOR and leucine. 1 / 1
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reach
"Thus, there may be one or more Rag, Ragulator, and/or endosomal mechanisms by which sepsis disturbs the interaction of mTOR and Rheb culminating in leucine resistance."
MTOR affects RHEB, and htt
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RHEB binds MTOR and htt. 1 / 1
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sparser
"Pull-down experiments indicated that amino acids stimulated the interaction of Htt and the guanosine triphosphatase (GTPase) Rheb (a protein that stimulates mTOR activity), and that Htt forms a ternary complex with Rheb and mTOR."
MTOR affects RHEB, and TSC2
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RHEB binds TSC2 and MTOR. 1 / 1
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sparser
"The gene product of PKD1 , polycystin-1, interacts with TSC2, which forms a complex with the GTP-binding protein RHEB upstream of mTOR."
MTOR affects RHEB, TSC1, and TSC2
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RHEB binds TSC1, TSC2, and MTOR. 1 / 1
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sparser
"Full-length TSC2 protein interacts with TSC1 to inhibit the activation of mTOR by Rheb."
MTOR affects RHEB, TBC, and TSC
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TSC binds RHEB, MTOR, and TBC. 1 / 1
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reach
"The mTOR, Rheb, TSC, and TBC complex co and localizes to the lysosome and the phosphorylation of TSC-TBC effects the dissociation of the complex from the lysosome and activates Rheb."
MTOR affects RHEB, and RRAGC
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RHEB binds RRAGC and MTOR. 1 / 1
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sparser
"This resulted in increased Rheb and RagA/ RagC GTPase interactions with mTOR, as well as suppression of mTORC2."
MTOR affects RHEB, RRAGA, and RRAGC
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RHEB binds RRAGA, RRAGC, and MTOR. 1 / 1
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sparser
"In LD, eIF4E∙eIF4G complex formation, phosphorylation of TSC2, mTOR, and rpS6, and association of mTOR with RagA, RagC, and Rheb were increased by feeding and blunted by prematurity."
MTOR affects RHEB, RPTOR, and mTORC1
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MTORC1 binds RHEB, RPTOR, and MTOR. 1 / 1
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sparser
"The interaction of the mTORC1 components Rheb, mTOR and raptor, tagged with EGFP/DsRed was determined using fluorescence energy transfer-FLIM."
MTOR affects RHEB, and RPS6
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RHEB binds RPS6 and MTOR. 1 / 1
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sparser
"A constitutively active form of RHEB, RHEB-Q64L, which stimulates S6 phosphorylation through the activation of MTOR signaling, was transfected into U2OS cells to recover MTOR activity."
MTOR affects RALB, and RHEB
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RHEB binds MTOR and RALB. 1 / 1
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sparser
"Consistent with Rheb and RalB interacting with the same region of mTOR, we found that RalB could successfully compete with Rheb for mTOR binding ( xref )."
MTOR affects RAB5A, and RHEB
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RHEB binds MTOR and RAB5A. 1 / 1
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sparser
"Both Rab5 and Rheb interact in the mTOR pathway [ xref , xref ]."
MTOR affects RAB3IP, and RHEB
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RHEB binds RAB3IP and MTOR. 1 / 1
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sparser
"We studied the possibility of interaction between Rabin8, Rheb, and mTOR using transfection in HEK293 by simultaneous transfection of pcDNA3.1 and pCMVTag3A control vectors ( xref А, lane 1) or two vectors expressing Rabin8 and Myc-Rheb fusion protein ( xref А, lanes 2– 4 ) in a medium with ( xref A, lanes 1 and 2) or without growth factors ( xref A, lane 3), as well as after short-term stimulation of the cells grown for 24 hr without growth factors ( xref А, lane 4)."
MTOR affects PYD1, and RHEB
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RHEB binds MTOR and PYD1. 1 / 1
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sparser
"This may be due to reduction in AMP-activated protein kinase signaling [ xref ] or due to the decreased interaction of glyceraldehyde 3-phosphate dehydrogenase and Rheb [ xref ], each of which would promote mTOR activation (specifically, the mTORC1 complex) by the small GTPase Rheb ( xref )."
LAMP1 affects MTOR, and RHEB
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RHEB binds MTOR and LAMP1. 1 / 1
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sparser
"The availability of amino acids stimulates the translocation of mTORC1 to the lysosomal surface, where it associates with Rheb resulting in activation of mTOR kinase [ xref , xref ]."
GST affects MTOR, and RHEB
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GST binds RHEB and MTOR. 1 / 1
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"Notably, the inactive Rheb switch 1 mutant Thr38Met binds endogenous mTOR in a manner equivalent to wild-type GST-Rheb, whereas mTOR binding to Rheb Ile39Lys and to GST-Rheb Gln64Leu is reduced as com[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
GST affects Hemagglutinins, MTOR, and RHEB
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sparser
"Somewhat lesser amounts of HA-mTOR polypeptide are recovered with GST-Rheb(Gln64Leu) as compared with wild-type GST-Rheb ( Figure 7 B); however, when comparable amounts of Rheb bound HA-mTOR polypepti[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
ENPP1 affects MTOR, RHEB, and TSC2
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RHEB binds TSC2, ENPP1, and MTOR. 1 / 1
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reach
"Also a PC1, Tuberin, Rheb, and mTOR complex model is proposed to illustrate the role of Tuberin in mTOR signaling pathway 40."
CD36 affects MTOR, and RHEB
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RHEB binds CD36 and MTOR. 1 / 1
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sparser
"A cryo-EM structure of Rheb bound to mTORC1 revealed that the Switch II region of Rheb interacts with the mTOR N-heat, M-heat, and FAT domains."
BNIP3L affects MTOR, and RHEB
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RHEB binds BNIP3L and MTOR. 1 / 1
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sparser
"By contrast, the interaction of NIX with Rheb elicited mTOR- independent effects on cell growth [ xref ]."
AKT1S1 affects MTOR, RHEB, and RPTOR
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sparser
"Moreover, changes in mTORC1 activity correlated directly with altered association of mTOR with RagB/RagC, Rheb, raptor, and PRAS40."