IndraLab
Statements
sparser
"Two materials from the acrylic resin group, Jet denture repair acrylic and Duralay, showed higher pushout forces, indicating a better bond with Lucitone 199 CAD-CAM denture base material compared with other tested materials, including composite resin with bonding agent (EZ PickUp, Quick Up, and Triad gel) and composite resin without bonding agent (Chairside)."
sparser
"As seen in the limited contemporary literature on subperiosteal implants (Table xref ), despite the use of CAD‐CAM techniques and improved perioperative optimization, subperiosteal implants still have unpredictable outcomes in comparison to endosseous osseointegrated implants, with the most common failures continuing to be hardware exposure and mobility."
Multiple Myeloma binds Dr and CALM1. 4 / 4
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"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
sparser
"Another significant resource is the Cam-CAN (N = 16) database, a large-scale collaborative research project by the University of Cambridge, which aims to use epidemiological, cognitive, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age."
sparser
"To test our claim, we evaluate the degree of neural coordination using phase synchrony measures xref at different regimes of alpha frequency band in resting-state MEG recordings collected from participants aged 18–88 at the Cambridge Center for Ageing and Neuroscience (Cam-CAN) xref ."
sparser
"To test this hypothesis, the CHR-outcome-neurosignature derived from the PRONIA study, was used to build a binary classifier which was applied to sMRI data of participants from the Human Connectome Project (HCP) ( xref ) and the Cambridge Centre for Ageing and Neuroscience project (Cam-CAN) ( xref )."
sparser
"We predicted that if the neuroanatomical correlates of social dysfunction in CHR-P individuals were on a continuum with the general population, then HCP and Cam-CAN participants whose neuroanatomical profiles were aligned with the PRONIA CHR-outcome-neurosignature would also present with social difficulties."
sparser
"It is unlikely that these findings are attributable to misidentification of future psychosis cases in the HCP and Cam-CAN as no more than 15 individuals in both samples combined could ever present with schizophrenia assuming an approximate lifetime prevalence of 8/1000 persons ( xref )."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
GO affects CALM1
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"There are three existing tools that can be independently completed by family caregivers – the FAM-CAM, the informant Assessment of Geriatric Delirium (I-AGeD) and the Sour Seven. xref – xref A strength of the FAM-CAM is that it allows families to systematically report their observations of features of delirium, as well as to detail when the changes (i.e., whether or not the changes were acute or progressive) began and if they have been getting better or worse (items 8 to 11)."
sparser
"As for informant-based tools such as the Single Question in Delirium (SQiD) which asks ‘ Is this patient more confused than before ’, the FAM-CAM has the benefit of including information on additional features of delirium while not adding burden to the clinicians in the ED. xref The FAM-CAM may be especially helpful in cases when patients present with ‘confusion’ or altered mental status’ as the chief complain associated with the ED visit, common in our cohort, and in patients with dementia where confusion may be part of the patient’s baseline."
CALM1 affects B3LYP
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"They demonstrated that the overestimation by 0.5 eV (in respect to the experimental data) of the transition energy for the relevant TPA state in [5,15-bis(3,5-bitert-butylphenyl)-10,20-bis(trihexylsilylethynyl)porphyrinato]zinc by B3LYP led to a 5-fold overprediction of the TPA cross-section for this molecule, whereas for 5,5′-(ethyne)bis[[10,20-bis(3,5-bitert- butylphenyl)-porphyrinato]zinc], underestimation of the transition energy by 0.5 eV with CAM-B3LYP and by 0.8 eV with B3LYP lead to underestimations of the TPA cross-section by factors of 2 and 4, respectively [ xref ]."
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CALM1 is modified
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CALM1 is phosphorylated.
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sparser
"An involvement of mTORC2 in calcium regulation in muscle is also supported by the decrease in the phosphorylation of calmodulin 1 (CALM1) in Ric mKO muscle, since
calmodulins are calcium ion sensor proteins that transduce most of the calcium signalling to downstream protein kinases and phosphatases (Marcelo et al. 2016)."
CALM1 is acetylated.
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sparser
"This may be due to the lower affinity of Myo1 for unmodified Cam1, which would bring about dissociation of the two proteins at lower concentrations of cellular calcium, despite the pCa of the interaction being unaffected by Cam1 acetylation, and therefore failure to associate with the membrane."
sparser
"Using biochemical analysis of recombinant bacterially expressed amino‐terminally acetylated Cam1, we show this post‐translational modification impacts the helical structure and thermal stability of the Cam1 protein, enhancing its sensitivity to Ca 2+ and affinity for its major cellular binding partner, Myo1."
sparser
"It is worth noting that the proportion of native yeast Cam1 that is acetylated on its amino‐terminus within the yeast cell (40%) [ xref ], generating a subpopulation of CaM with distinct biophysical properties, coincides precisely with the proportion of discrete Cam1 foci (40%) that associates with Myo1 in the fission yeast cell [ xref ]."
CALM1 is methylated.
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"The results showed CALM1 methylation to be significantly increased in cervical and endocervical cancer (CESC) and COAD compared with that in normal tissues, but significantly decreased in LIHC and PCPG ( xref ), showing an inverse trend compared with that of the expression pattern."
sparser
"The recently completed genome of pineapple has and will continue to facilitate many areas of research in this species, and the present work focuses on the regulatory impact of DNA methylation on CAM pathway-related genes using temporal and spatial methylome and transcriptome analysis."
CALM1 is glycosylated.
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"In addition, studies in our laboratories have been performed and are still in progress, mainly aimed to elucidate the expression and significance of the CAM glycosylation patterns, as well as to identify and characterize membrane molecular components implicated in the ion transport processes which occur in the chorionic epithelium [ xref – xref ]."
sparser
"Further advances in production of metal coatings with finer granularity, together with improvements in imaging (tilting and angle of stereo images), may provide better definition of the topography associated with glycosylation and formation of multimeric CAM complexes. (J Histochem Cytochem 49:809-819, 2001)"
sparser
"These same resonances are exchange broadened in CaM bound to the CNGB1 CaM1 peptide (Bej and Ames xref ) and the α-subunit of the retinal cyclic nucleotide-gated channel (CNGA2) (Contessa et al. xref ), but are not exchange broadened in free CaM (Bej and Ames xref ; Kainosho et al. xref )."
reach
"These results suggest that CaM is produced by the CALM1 gene in the early-stage HDFs with an altered dermal composition, and that they are activated in the biological pathways associated with calcium ions.Since calcium signaling is presumably associated with the differentiation of fibroblasts in the elastin-variable hydrogel environments, we assessed the expression of S100A4 (also called fibroblast-specific protein 1, FSP1), which is a marker of differentiated fibroblasts as well as a calcium-binding protein."
sparser
"The UB-2 can effectively rule out delirium in less than 40 seconds, with a 93% sensitivity in persons with and without dementia. xref , xref If the person correctly answers both items in the UB-2, the protocol is complete; if not, the 3D-CAM is administered as step two. xref , xref The 3D-CAM is a validated diagnostic interview for delirium that can be completed in three minutes. xref We refer to this two-step process as the UB-CAM. (See xref , xref , xref )"
sparser
"These same resonances are exchange broadened in CaM bound to the CNGB1 CaM1 peptide (Bej and Ames xref ) and the α-subunit of the retinal cyclic nucleotide-gated channel (CNGA2) (Contessa et al. xref ), but are not exchange broadened in free CaM (Bej and Ames xref ; Kainosho et al. xref )."
EP affects CALM1
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"Finally, levels of epithelial cell adhesion molecule (Ep‐CAM) and E‐selectin (SELE) found exclusively in epithelial and endothelial cells, respectively, were significantly higher in SEVs from patients with severe disease, albeit a less than 1.5‐fold increase compared to the uninfected controls."
sparser
"For example, activity of the core AJ components E-cadherin (E-cad) and α-catenin (α-cat) has been linked to activation of the core Hippo kinase LATS1/2 and inhibition of YAP ( xref ; xref ; xref ), and in Drosophila the Ig-CAM protein Echinoid that localizes to AJs can promote Salvador/Hpo activity to inhibit Yki ( xref )."
sparser
"They contain a furin-like cleavable domain and transmembrane domains, i.e., C-terminal TM-1 and cytoplasmic tail. (f) Membrane-type MMPs, including MMP-17 and MMP-25, resemble archetypal MMPs and contain a C-terminal glycosylphosphatidylinositol (GPI) membrane anchor. (g) Other MMPs (MMP-23A and MMP-23B) also resemble archetypal MMPs, lack a hemopexin domain and contain N-terminal TM-II and cytoplasmic C-terminal immunoglobulin-like cell adhesion molecule (Ig-CAM) domains [ xref , xref ]."
NET affects CALM1
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Isotocin-neurophysin IT 1 affects CALM1
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CR affects CALM1
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CALM1 affects Isotocin-neurophysin IT 1
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CALM1 affects CR
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ESP32 affects CALM1
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sparser
"PubMed, EMBASE® and the Cochrane Central Register of Controlled Trials (CCTR) were systematically reviewed for research articles pertaining to known CYP mediated CAM-drug interactions; case reports describing adverse events in patients, and clinical trials which examined the effects of herbs and supplements used during cancer treatment."
CALM1 affects calcium(2+)
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CALM1 binds calcium(2+).
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CALM1 binds calcium(2+). 10 / 26
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"These marker proteins are listed in Table S-6 and include for instance calmodulin-1, MARCS, and the peptidyl-prolyl cis-trans isomerase FKBP9, which bind calcium; proteins with chaperone function (CH60, HSPB1, PRS4, and TCPA); components of the nuclear lamina (LMNA, LMNB1), as well as an interferon-induced GTP-binding protein (MX1); and vimentin, a class III intermediate filament."
CALM1 activates calcium(2+).
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CALM1 activates calcium(2+). 8 / 8
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"The facilitating effect of CaM1 was significantly enhanced (the K value was reduced from 0.61 to 0.28), but the inhibitory effect was significantly decreased (the K value was increased from 8 to 12) (Fig. 4q; Table S12), indicating that activation of CaM1 and L-VGCC by scoparone likely induced excessive activation of Ca signalling pathways by promoting CDF or blocking CDI of L-VGCC."
CALM1 inhibits calcium(2+).
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"Zhang et al. [ xref ] used 3D densely connected convolutional neural network (CAM-CNN) to extract brain MRI multilevel features for classification of Alzheimer's disease and mild cognitive impairment, densely connected difference at different unit levels; 3D dense unit introduces attention mechanism to generate attention maps and sum transformed MRI hierarchical data into more compact high-level; model has high classification prediction accuracy, and classification performance is at the highest level."
Calcium(2+) affects CALM1
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Calcium(2+) binds CALM1.
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CALM1 binds calcium(2+). 10 / 26
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"These marker proteins are listed in Table S-6 and include for instance calmodulin-1, MARCS, and the peptidyl-prolyl cis-trans isomerase FKBP9, which bind calcium; proteins with chaperone function (CH60, HSPB1, PRS4, and TCPA); components of the nuclear lamina (LMNA, LMNB1), as well as an interferon-induced GTP-binding protein (MX1); and vimentin, a class III intermediate filament."
Calcium(2+) activates CALM1.
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Calcium(2+) activates CALM1. 7 / 7
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"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+–CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the E–F hands in each domain and dramatically changes the two domains of CaM to produce more ‘open’ conformations"
sparser
"A possible explanation is as follows: the percentage cumulative release of PVA-CAM is found to be a systematic and controlled release due to their less cytotoxic effects on blood cells, whereas the percentage cumulative release of uncapped-AgNPs is found to have a faster and sudden release profile due to the absence of a capping agent and their high toxicity to blood cells."
sparser
"Similarly on the 14 th day after excision wound injury, treatment with PVA-CAM showed an equal maximum regeneration of fibroblast and collagen and was significantly more effective and angiogenic compared with CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a moderate amount of collagen and fibroblast regeneration, with scant inflammation during their healing process."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (gene:vWF), Jagged 1 (gene:JAG1), Laminin subunit alpha 2 (gene:LAMA2), Thrombospondin-2 (gene:TSP2), and Collagen IV (gene:COL4)) but do not recognize specific proteins such as Bovine serum albumin (gene:BSA) and human Thrombospondin-1 (gene:TSP1), Biglycan (gene:BGN) and Decorin (gene:DCN)."
sparser
"To enhance the potential for antibodies to bind to reduced protein on immunoblots, a peptide corresponding to this sequence (CFDPKYGEPKRPPNCARGSCPWDSQL; accession # NP_001138585.2) was generated with a reduced N-terminal anchoring cysteine and two CAM-cys residues in place of the remaining native cysteines."
sparser
"Of the antibodies identified by ELISA, we found by dot blotting that two rabbit IgG monoclonals (4E7 and 52H11) bound to the CAM-cys modified MYADML2 peptides but were incapable of binding to peptides lacking CAM-cys modifications (peptide sequences shown in xref ; blots shown in xref [probed with 4E7],1C [with 52H11], and 1D [with secondary antibody alone])."
sparser
"A possible explanation is as follows: the percentage cumulative release of PVA-CAM is found to be a systematic and controlled release due to their less cytotoxic effects on blood cells, whereas the percentage cumulative release of uncapped-AgNPs is found to have a faster and sudden release profile due to the absence of a capping agent and their high toxicity to blood cells."
sparser
"Similarly on the 14 th day after excision wound injury, treatment with PVA-CAM showed an equal maximum regeneration of fibroblast and collagen and was significantly more effective and angiogenic compared with CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a moderate amount of collagen and fibroblast regeneration, with scant inflammation during their healing process."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (gene:vWF), Jagged 1 (gene:JAG1), Laminin subunit alpha 2 (gene:LAMA2), Thrombospondin-2 (gene:TSP2), and Collagen IV (gene:COL4)) but do not recognize specific proteins such as Bovine serum albumin (gene:BSA) and human Thrombospondin-1 (gene:TSP1), Biglycan (gene:BGN) and Decorin (gene:DCN)."
sparser
"To enhance the potential for antibodies to bind to reduced protein on immunoblots, a peptide corresponding to this sequence (CFDPKYGEPKRPPNCARGSCPWDSQL; accession # NP_001138585.2) was generated with a reduced N-terminal anchoring cysteine and two CAM-cys residues in place of the remaining native cysteines."
sparser
"Of the antibodies identified by ELISA, we found by dot blotting that two rabbit IgG monoclonals (4E7 and 52H11) bound to the CAM-cys modified MYADML2 peptides but were incapable of binding to peptides lacking CAM-cys modifications (peptide sequences shown in xref ; blots shown in xref [probed with 4E7],1C [with 52H11], and 1D [with secondary antibody alone])."
sparser
"To assess the selectivity of the immunosensing platform and ensure that the change in the current is due to antigen binding and not the settling of proteins on the surface, a test of some compounds that may be in negative controls of real samples was conducted, including bovine serum albumin (BSA), carcinoembryonic antigen (CEA-CAM), prostate-specific antigen (PSA), 20S proteasome, ascorbic acid (AA), glucose, and dopamine."
sparser
"Additionally, CR can act on the genes of the upstream pathway, such as IL1B and TNF, which are proinflammatory mediators [ xref , xref ], while ATR can act on downstream genes, such as CALM1 and NOS3, which are associated with learning and memory and anti-inflammatory processes."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"CALM1 encodes a regulatory protein of RYR2 and is responsible for inhibiting Ca 2+ release from RYR2 in the sarcoplasmic reticulum to maintain a normal contraction‐relaxation cycle. xref Oxidative stress impairs binding of CALM1 to RYR2 , causing aberrant Ca 2+ release, resulting in cardiac hypertrophy and HF in murine and canine models. xref , xref Our results suggest that estradiol treatment led to tighter control of cardiac Ca 2+ physiology and improved diastolic relaxation."
sparser
"Of these, six LR interactions were highlighted by both analyses, including APOE-SORL1 , APOE-LRP1, CALM1-CACNA1C, CALM1-RYR2, CALM3-CACNA1C, CALM3-RYR2 ( xref ). xref illustrates that the LR pair APOE-SORL1 was downregulated in astrocytes-to-neurons and in microglia-to-neurons signaling."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
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CALM1 phosphorylates itself.
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rlimsp
"Autophosphorylation of CaM-kinase II produces a form of the enzyme not requiring Ca(2+)/calmodulin for sustained activity. We report that autophosphorylated CaM-kinase II dephosphorylates itself in the presence of ADP (termed autodephosphorylation). The dephosphorylation was unaffected by phosphatase inhibitors and was nucleotide specific, occurring with ADP but not with AMP, GTP, or GDP. (32)P-ATP was produced when ADP was added to (32)P-labeled CaM-kinase II, indicating that the enzyme was undergoing dephosphorylation through a reversal of the autophosphorylation reaction. ATP addition also produced loss of (32)P from the autophosphorylated enzyme while maintaining the kinase in a phosphorylated state."
rlimsp
"Along with information from the crystal structure of Ca2+/CaM bound to CKII(290-314) (Meador, W. E., Means, A. R., and Quiocho, F. A. (1993) Science 262, 1718-1721), our results suggest a model in which CaM-dependent autophosphorylation of CaM-kinase induces a conformational change in the region of the CaM-binding domain which allows the formation of additional stabilizing interactions with CaM."
CALM1 binds.
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"Five strains were sensitive to all four antibiotics (S1-S5), 6 strains were resistant to MTZ (MTZ1-MTZ6), 5 strains were resistant to LVFX (LVFX1-LVFX5), 5 strains were resistant to CAM (CAM1-CAM5), 3 strains exhibited dual drug resistance (DR1-DR3), and 6 strains were multidrug resistant (MDR1-MDR6)."
CALM1 is inactive.
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"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
CALM1 affects apoptotic process
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sparser
"CALM1 encodes a regulatory protein of RYR2 and is responsible for inhibiting Ca 2+ release from RYR2 in the sarcoplasmic reticulum to maintain a normal contraction‐relaxation cycle. xref Oxidative stress impairs binding of CALM1 to RYR2 , causing aberrant Ca 2+ release, resulting in cardiac hypertrophy and HF in murine and canine models. xref , xref Our results suggest that estradiol treatment led to tighter control of cardiac Ca 2+ physiology and improved diastolic relaxation."
sparser
"Of these, six LR interactions were highlighted by both analyses, including APOE-SORL1 , APOE-LRP1, CALM1-CACNA1C, CALM1-RYR2, CALM3-CACNA1C, CALM3-RYR2 ( xref ). xref illustrates that the LR pair APOE-SORL1 was downregulated in astrocytes-to-neurons and in microglia-to-neurons signaling."
reach
"Additionally, the CaM1 assay showed that compared with the control treatment, treatment with the LC , LC , and LC doses of scoparone for 48 h markedly increased the specific activation of PDE by extracted CaM in vivo (by 3.67-, 2.79-, and 1.87-fold, respectively), further demonstrating that scoparone is an agonist of CaM1 (Fig. 4d)."
NAChRbeta2 affects CALM1
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CALM1 binds nAChRbeta2. 10 / 17
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sparser
"Histopathological studies on treatment with PVA-CAM in the excision wound model showed a maximum amount of fibroblast presence and collagen regeneration after the 9 th day of the healing process, which was found to be comparatively more effective than CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a minimal amount of fibroblast and collagen regeneration, with the presence of dense inflammation."
sparser
"These findings indicate that PVA-CAM have a predominant antibacterial activity and accelerate the healing potential of excision wound models in Wistar albino rats by enhancing angiogenesis in the wounded sections and are comparatively more efficient (among polymers) than uncapped-CAM, SBD-CAM or untreated wounds (the control)."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
CALM1 affects nAChRbeta2
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CALM1 binds nAChRbeta2. 10 / 17
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sparser
"Histopathological studies on treatment with PVA-CAM in the excision wound model showed a maximum amount of fibroblast presence and collagen regeneration after the 9 th day of the healing process, which was found to be comparatively more effective than CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a minimal amount of fibroblast and collagen regeneration, with the presence of dense inflammation."
sparser
"These findings indicate that PVA-CAM have a predominant antibacterial activity and accelerate the healing potential of excision wound models in Wistar albino rats by enhancing angiogenesis in the wounded sections and are comparatively more efficient (among polymers) than uncapped-CAM, SBD-CAM or untreated wounds (the control)."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
CALM1 affects cell adhesion
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CALM1 activates cell adhesion. 10 / 16
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"At least eleven at : subunits can combine with seven / 3 subunits to yield at Ieast 16 heterodimers and these numbers are still increasing.The Leu Cam ieucocyte receptors also belong to this superfamily and mediate adhesion of polymorphonuclears, monocytes and lymphocytes to each other and to a complement component, C3bi 1841."
sparser
"Both CALM1 and PPP3CA play essential roles in the transduction of intracellular Ca(2+)-mediated signals, in that CALM1 encodes calcium binding protein which is a subunits of phosphorylase kinase and can bind PPP3CA regulatory domain and causes a conformational change in removing PPP3CA autoinhibitory domain from its catalytic site, i.e., activating PPP3CA ( xref )."
CALM1 affects AP180
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"(a) VEGF 0 (DMEM soaked implant), VEGF 30 (30 ng/implant), VEGF 100 (100 ng/implant) and VEGF 300 (300 ng / implant) induced CAM angiogenic response in absence of coronary endothelial cells (AcEC), in presence of ischemia reperfusion injured coronary endothelial cells (2 A 106 cells/ml, 0.5 A 104 cells and implant) of diabetic 60 ds."
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"(a) VEGF 0 (DMEM soaked implant), VEGF 30 (30 ng/implant), VEGF 100 (100 ng/implant) and VEGF 300 (300 ng / implant) induced CAM angiogenic response in absence of coronary endothelial cells (AcEC) and in presence of coronary endothelial cells (2 A 106 cells/ml, 0.5 A 104 cells and implant) of normal (+ ncEC) rats, diabetic rats 30 ds."
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"(a) VEGF 0 (DMEM soaked implant), VEGF 30 (30 ng/implant), VEGF 100 (100 ng/implant) and VEGF 300 (300 ng / implant) induced CAM angiogenic response in absence of coronary endothelial cells (AcEC), in presence of ischemia reperfusion injured coronary endothelial cells (2 A 106 cells/ml, 0.5 A 104 cells and implant) of diabetic 30 ds."
sparser
"Another retrospective study on the efficacy of an AI-based algorithm, the Natural Language Processing Confusion Assessment Method (NLP-CAM), in detecting delirium based on EMRs of COVID-19 patients admitted to hospitals revealed an increased rate of detection by the NLP-CAM algorithm of 80% as compared to physician diagnosis of 55% [ xref ]."
sparser
"The 3 calmodulin genes ( CALM1-3 ) were scored separately but discussed as a group because they all encode for an identical protein. xref CALM1 and CALM2 were first associated with LQTS by exome sequencing of 2 unrelated infants with QT prolongation where de novo variants were identified. xref Subsequent studies uncovered further genetic evidence for these genes, including CALM3. xref – xref Most recently, the International Calmodulinopthy Registry has published a series of 36 LQTS cases secondary to rare variants distributed among all 3 CALM genes. xref In all cases identified, no other family members were found to be phenotype-positive and were thus concordant with de novo variants, although not in all families was this proven by sequencing of both parents and confirmation of paternity."
sparser
"CaM binding decreases the CNG channel-binding affinity for cGMP and causes decreased Ca 2+ influx. xref , xref Two CaM-binding sites are located in CNGB1 called CaM1 (residues 565–589) and CaM2 (residues 1120–1147) ( xref ). xref , xref , xref CaM1 is required for Ca 2+ -dependent modulation of the CNGA1/CNGB1 heteromeric channels. xref , xref The function of CaM2 is not known, but CaM2 is located adjacent to the CNBD where it could affect ligand binding. xref A recent cryoEM structure of the retinal CNG channel revealed that a helix within CNGB1 is bound to the C-terminal domain of CaM (residues 80–149, called the C-lobe). xref However, the cryoEM structure lacked sufficient resolution to distinguish whether the CaM C-lobe is bound to CaM1 or CaM2, and the CaM N-lobe (residues 1–80) was completely missing in the structure."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
CALM1 affects angiogenesis
|
10
5
CALM1 activates angiogenesis.
|
8
CALM1 activates angiogenesis. 8 / 8
|
8
reach
"The CAM (Chick Chorioallantoic Membrane) model allows the assessment of the degree of angiogenesis, as well as the quality of the newly formed vessels, when intervening vascular endothelial growth factors (VEGF) or conversely, factors that inhibit the development of new blood vessels, such as antiangiogenic drugs."
CALM1 inhibits angiogenesis.
|
2
5
sparser
"Another retrospective study on the efficacy of an AI-based algorithm, the Natural Language Processing Confusion Assessment Method (NLP-CAM), in detecting delirium based on EMRs of COVID-19 patients admitted to hospitals revealed an increased rate of detection by the NLP-CAM algorithm of 80% as compared to physician diagnosis of 55% [ xref ]."
sparser
"The 3 calmodulin genes ( CALM1-3 ) were scored separately but discussed as a group because they all encode for an identical protein. xref CALM1 and CALM2 were first associated with LQTS by exome sequencing of 2 unrelated infants with QT prolongation where de novo variants were identified. xref Subsequent studies uncovered further genetic evidence for these genes, including CALM3. xref – xref Most recently, the International Calmodulinopthy Registry has published a series of 36 LQTS cases secondary to rare variants distributed among all 3 CALM genes. xref In all cases identified, no other family members were found to be phenotype-positive and were thus concordant with de novo variants, although not in all families was this proven by sequencing of both parents and confirmation of paternity."
sparser
"CaM binding decreases the CNG channel-binding affinity for cGMP and causes decreased Ca 2+ influx. xref , xref Two CaM-binding sites are located in CNGB1 called CaM1 (residues 565–589) and CaM2 (residues 1120–1147) ( xref ). xref , xref , xref CaM1 is required for Ca 2+ -dependent modulation of the CNGA1/CNGB1 heteromeric channels. xref , xref The function of CaM2 is not known, but CaM2 is located adjacent to the CNBD where it could affect ligand binding. xref A recent cryoEM structure of the retinal CNG channel revealed that a helix within CNGB1 is bound to the C-terminal domain of CaM (residues 80–149, called the C-lobe). xref However, the cryoEM structure lacked sufficient resolution to distinguish whether the CaM C-lobe is bound to CaM1 or CaM2, and the CaM N-lobe (residues 1–80) was completely missing in the structure."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
sparser
"This binding is prohibited by mutation of two amino acid residues (L 18 R and W 21 R, corresponding to L 456 R and W 459 R in full-length MLO2) that are in analogous positions within the CAMBD to those that were previously identified as being essential for the binding of CAM to barley and rice MLO proteins ( xref ; xref )."
sparser
"This binding is prohibited by mutation of two amino acid residues (L 18 R and W 21 R, corresponding to L 456 R and W 459 R in full-length MLO2) that are in analogous positions within the CAMBD to those that were previously identified as being essential for the binding of CAM to MLO proteins in monocotyledonous plants (barley and rice; [ xref , xref ])."
sparser
"LC-MRM peaks were integrated, and relative peak areas for each transition (transition/sum of all transitions) as well as retention times were compared with HP-CAM signals for the same peptide. xref shows a representative example of a confirmed target LC-MRM for a mouse CYP 2C29 peptide, found via data-dependent MS/MS and confirmed by MRM analyses."
CM affects CALM1
|
14
sparser
"One possible problematic outcome of such dismissal is that patients, who already anticipate this negative response, may choose not to discuss their concurrent use of treatments with their HCP, and as such may assume the entire burden of managing the interactions of CM and CAM without any medical guidance, which puts them at a great health risk [ xref , xref ]."
sparser
"This binding is prohibited by mutation of two amino acid residues (L 18 R and W 21 R, corresponding to L 456 R and W 459 R in full-length MLO2) that are in analogous positions within the CAMBD to those that were previously identified as being essential for the binding of CAM to barley and rice MLO proteins ( xref ; xref )."
sparser
"This binding is prohibited by mutation of two amino acid residues (L 18 R and W 21 R, corresponding to L 456 R and W 459 R in full-length MLO2) that are in analogous positions within the CAMBD to those that were previously identified as being essential for the binding of CAM to MLO proteins in monocotyledonous plants (barley and rice; [ xref , xref ])."
sparser
"LC-MRM peaks were integrated, and relative peak areas for each transition (transition/sum of all transitions) as well as retention times were compared with HP-CAM signals for the same peptide. xref shows a representative example of a confirmed target LC-MRM for a mouse CYP 2C29 peptide, found via data-dependent MS/MS and confirmed by MRM analyses."
CALM1 affects CM
|
14
sparser
"One possible problematic outcome of such dismissal is that patients, who already anticipate this negative response, may choose not to discuss their concurrent use of treatments with their HCP, and as such may assume the entire burden of managing the interactions of CM and CAM without any medical guidance, which puts them at a great health risk [ xref , xref ]."
sparser
"Both CALM1 and PPP3CA play essential roles in the transduction of intracellular Ca(2+)-mediated signals, in that CALM1 encodes calcium binding protein which is a subunits of phosphorylase kinase and can bind PPP3CA regulatory domain and causes a conformational change in removing PPP3CA autoinhibitory domain from its catalytic site, i.e., activating PPP3CA ( xref )."
"Phosphorylation of CaM at four sites by CK2 was found to follow a sequential order, with Ser81 as the first, Thr79 as the second, and Ser101 or Thr117 as the third. We found that in the complex between CaM and CaMKII, residue E115 of CaM is strongly interacting with K299 of the kinase through forming a salt-bridge (PDB entry 1WEL), it is quite likely that the phosphorylation induced structural change can disrupt this interaction and negatively affect the binding between the two proteins"
sparser
"As holism is one of the main features that most of the practices defined (by Western) alternative or New Age share, I also refer to CAM-NAt as holistic practices.
Anthropology & Medicine
3
Several studies have found that middle-class women (Kligman 1998; Ross 2012; Woodhead 2007) are those who are most frequently drawn to CAM and NAt."
sparser
"Treatment was given on predetermined days, in which the prepared matrix scaffolds were used as substrates for impregnation of AgNPs. xref The process includes the exposure of various synthesized scaffolds ( i.e. , CAM alone, uncapped-CAM, capped = TSC-CAM, PVP-CAM and PVA-CAM, SBD-CAM) which were allowed to react on alternate days with the wound area in order to initiate the inflammatory phase followed by the other phases."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"Finally, PVA-AgNPs, PVP-AgNPs, TSC-AgNPs, uncapped-AgNPs and SBD-suspensions were incorporated into the formulated polymeric matrix to form PVA-AgNP impregnated CAM (PVA-CAM), PVP-AgNP impregnated CAM (PVP-CAM), TSC-AgNP impregnated CAM (TSC-CAM), uncapped-AgNP impregnated CAM (uncapped-CAM) and SBD-suspension impregnated CAM (SBD-CAM), respectively, and freeze dried for further analysis."
sparser
"Wound treatment with uncapped-CAM after the 9 th day of observation showed skin tissue with dense inflammation, an absence of fibroblast development and a very minimal amount of collagen regeneration, and was found to be comparatively less effective than CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM."
sparser
"Although the percentage wound contraction for PVP-CAM, TSC-CAM and SBD-CAM was quite a bit higher than for uncapped-CAM and the control group, wounds treated with PVA-CAM show the maximum significant wound contraction ( p ≤ 0.001) efficiency due to their biocompatibility with wound tissue."
sparser
"Similarly on the 14 th day after excision wound injury, treatment with PVA-CAM showed an equal maximum regeneration of fibroblast and collagen and was significantly more effective and angiogenic compared with CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a moderate amount of collagen and fibroblast regeneration, with scant inflammation during their healing process."
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
sparser
"As holism is one of the main features that most of the practices defined (by Western) alternative or New Age share, I also refer to CAM-NAt as holistic practices.
Anthropology & Medicine
3
Several studies have found that middle-class women (Kligman 1998; Ross 2012; Woodhead 2007) are those who are most frequently drawn to CAM and NAt."
sparser
"Treatment was given on predetermined days, in which the prepared matrix scaffolds were used as substrates for impregnation of AgNPs. xref The process includes the exposure of various synthesized scaffolds ( i.e. , CAM alone, uncapped-CAM, capped = TSC-CAM, PVP-CAM and PVA-CAM, SBD-CAM) which were allowed to react on alternate days with the wound area in order to initiate the inflammatory phase followed by the other phases."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"Finally, PVA-AgNPs, PVP-AgNPs, TSC-AgNPs, uncapped-AgNPs and SBD-suspensions were incorporated into the formulated polymeric matrix to form PVA-AgNP impregnated CAM (PVA-CAM), PVP-AgNP impregnated CAM (PVP-CAM), TSC-AgNP impregnated CAM (TSC-CAM), uncapped-AgNP impregnated CAM (uncapped-CAM) and SBD-suspension impregnated CAM (SBD-CAM), respectively, and freeze dried for further analysis."
sparser
"Wound treatment with uncapped-CAM after the 9 th day of observation showed skin tissue with dense inflammation, an absence of fibroblast development and a very minimal amount of collagen regeneration, and was found to be comparatively less effective than CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM."
sparser
"Although the percentage wound contraction for PVP-CAM, TSC-CAM and SBD-CAM was quite a bit higher than for uncapped-CAM and the control group, wounds treated with PVA-CAM show the maximum significant wound contraction ( p ≤ 0.001) efficiency due to their biocompatibility with wound tissue."
sparser
"Similarly on the 14 th day after excision wound injury, treatment with PVA-CAM showed an equal maximum regeneration of fibroblast and collagen and was significantly more effective and angiogenic compared with CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a moderate amount of collagen and fibroblast regeneration, with scant inflammation during their healing process."
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
TM affects CALM1
|
10
sparser
"The data for CAM-Tm fall very close to those for the parent, but the
former define a slightly,
but distinctly,
biphasic curve (three inflection
points) that is below that of the parent in the range 40-50°C.
The data for carboxymethylated
tropomyosin (CM-Tm) are shown as open
circles in Fig. 2, along with spline curves for Tm (dotted) and CAM-Tm
(solid)."
sparser
"The World Health Organization (WHO) reported that between 70% and 90% of the populations of Canada, France, Germany, and Italy have used some form of TM or CAM and that 110 of the 193 WHO member states reported having some type of policy in place regarding regulation and/or registration of traditional medications in 2007 [ xref ]."
SP affects CALM1
|
10
sparser
"Additionally, CR can act on the genes of the upstream pathway, such as IL1B and TNF, which are proinflammatory mediators [ xref , xref ], while ATR can act on downstream genes, such as CALM1 and NOS3, which are associated with learning and memory and anti-inflammatory processes."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"From an immunohistochemical point of view, EMPSGC is usually positive for Cytokeratin 7 (CK7), CK8, CK8/18, CKAE1/AE3, CK-CAM5.2, Epithelial Membrane Antigen (EMA), Gross Cystic Disease Fluid Protein-15 (GCDFP-15), WT1, Estrogen Receptor (ER), and Progesterone Receptor (PgR), but it is very important to underline the positivity for Synaptophysin (Syn) and/or Chromogranin A (CgA), Neuron-Specific Enolase (NSE), and CD56 [ xref , xref , xref ], which are markers of neuroendocrine differentiation."
sparser
"In terms of immunohistochemistry, MCC cells are positive for epithelial markers such as CK-CAM5.2, CKAE1-AE3, CK20, CK34BetaE12, BerEP4, and Epithelial membrane Antigen (EMA), PIEZO2 [ xref ], with some cases showing positivity for CK7 along with markers of neuroendocrine differentiation including chromogranin A (CgA), synaptophysin (Syn), and CD56 (NCAM1)."
sparser
"Of all the reviewed immunohistochemical stains, cytokeratins (CK-PAN, CK-CAM, CK7) were the most represented: 39 of 60 cases (65%) had diffuse immunohistochemical staining to at least one of the cytokeratins, while the remaining 21 cases (35%) had focal or mild positivity for one of them."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
CALM1 affects TM
|
10
sparser
"The data for CAM-Tm fall very close to those for the parent, but the
former define a slightly,
but distinctly,
biphasic curve (three inflection
points) that is below that of the parent in the range 40-50°C.
The data for carboxymethylated
tropomyosin (CM-Tm) are shown as open
circles in Fig. 2, along with spline curves for Tm (dotted) and CAM-Tm
(solid)."
sparser
"The World Health Organization (WHO) reported that between 70% and 90% of the populations of Canada, France, Germany, and Italy have used some form of TM or CAM and that 110 of the 193 WHO member states reported having some type of policy in place regarding regulation and/or registration of traditional medications in 2007 [ xref ]."
CALM1 affects SP
|
10
sparser
"From an immunohistochemical point of view, EMPSGC is usually positive for Cytokeratin 7 (CK7), CK8, CK8/18, CKAE1/AE3, CK-CAM5.2, Epithelial Membrane Antigen (EMA), Gross Cystic Disease Fluid Protein-15 (GCDFP-15), WT1, Estrogen Receptor (ER), and Progesterone Receptor (PgR), but it is very important to underline the positivity for Synaptophysin (Syn) and/or Chromogranin A (CgA), Neuron-Specific Enolase (NSE), and CD56 [ xref , xref , xref ], which are markers of neuroendocrine differentiation."
sparser
"In terms of immunohistochemistry, MCC cells are positive for epithelial markers such as CK-CAM5.2, CKAE1-AE3, CK20, CK34BetaE12, BerEP4, and Epithelial membrane Antigen (EMA), PIEZO2 [ xref ], with some cases showing positivity for CK7 along with markers of neuroendocrine differentiation including chromogranin A (CgA), synaptophysin (Syn), and CD56 (NCAM1)."
sparser
"Of all the reviewed immunohistochemical stains, cytokeratins (CK-PAN, CK-CAM, CK7) were the most represented: 39 of 60 cases (65%) had diffuse immunohistochemical staining to at least one of the cytokeratins, while the remaining 21 cases (35%) had focal or mild positivity for one of them."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
Myo1 affects CALM1
|
9
sparser
"Myo1 and Cam1 associated with the cell membrane in two distinct ways: we observed both (i) rapid, transient, binding of single Myo1 molecules to the cell membrane, characterized by low-intensity, single, stepwise, changes in intensity ( xref ), alongside (ii) longer endocytic events that were much brighter and took much longer ( xref )."
sparser
"If TORC2 does indeed phosphorylate Myo1, it would be important to know, first, whether TORC2 function is elevated in meiotic cells compared to mitotic cells and, second, what the effect of different growth conditions (vegetative, sexual, and nutrient limiting) is on the association of Myo1 with Cam1 vs. Cam2 as assessed via co-immunoprecipitations."
sparser
"The gene NCAN , a CNS-specific extracellular matrix protein whose expression has been linked to malignant behavior of neuroblastoma, xref and additional genes encoding cell surface proteins relevant for adhesion of neurons and leukocytes ( DSCAML1 , MAD-CAM1 ) also correlated significantly with OMAS neuroimmune symptoms."
sparser
"Throughout foetal development in mice, chemokines such as CXCL12 and -13, CCL19, -20 and -21, and adhesion molecules including vascular cell adhesion molecule 1 (VCAM-1), mucosal vascular addressing cell adhesion molecule 1 (MAD-CAM1) and intercellular adhesion molecule 1 (ICAM-1), altogether signal to promote the circulation of LTi cells and the migration of T- and B-lymphocytes into primordia resembling Peyer’s patches (Kunkel et al. xref ; Patel et al. xref )."
sparser
"Moreover, hypersialylation promotes tumor dissemination and metastasis by modulating the function of different integrins. xref For example, inhibiting sialylation in MM impairs interactions between tumor cells, VCAM1 and mucosal vascular addressin cell adhesion molecule 1 (MAD-CAM1) by altering the maturation of CD49d. xref Sialylation also participates in the generation of selectin ligands."
sparser
"These ligands include PSGL-1, the hemopoietic stem cell marker CD34, glycosylation-dependent cell adhesion molecule 1 (GlyCAM1) and mucosal addressin cell adhesion molecule 1 (MAd-CAM1), all of which contain a sulphated form of the sLe x tetrasaccharide. xref - xref However, there are other selectin ligands that occur naturally in humans which do not contain sLe x , the similar tetrasaccharide sLe a , nor structurally related carbohydrate moieties."
sparser
"The expression of some adhesion molecules on BM mononuclear cells was assessed by a panel
of MoAbs directed against: CD1 la, CDI lb, CDI lc, CD44, CD49d(VLA4), CD49e(VLA-5), LEC-CAM I.
P-170 expression
P-170 expression was evaluated by the MoAb C219 (Cis International, Centocor Diagnostics), which is an IgG2b antibody that recognizes a cytoplasmic antigen."
sparser
"The N-terminal domain (aa 22–138) of CALM contains the ANTH domain, which specifically binds to lipids (PtdIns(4,5)P 2 ) in the plasma membrane. xref , xref , xref , xref The three-dimensional structure of the N-terminal 280 amino acids of CALM has been solved and consists of 10 α-helices, which aggregate to form a globular protein. xref The C-terminal half of CALM, on the other hand, has most likely a poorly ordered structure that contains multiple short protein interaction motifs, functioning like a flexible ‘fishing line'. xref This composition of CALM permits the establishment of interactions during clathrin-coated pit assembly. xref Interestingly, FHL2 binds to β-integrin, xref which together with clathrin, a major binding partner of CALM, has been shown to be involved in endocytosis. xref , xref Taken together, these data suggest a role for the CALM–FHL2 interaction in the complex interaction network in endocytosis."
DRG affects CALM1
|
9
CALM1 affects Myo1
|
9
sparser
"Myo1 and Cam1 associated with the cell membrane in two distinct ways: we observed both (i) rapid, transient, binding of single Myo1 molecules to the cell membrane, characterized by low-intensity, single, stepwise, changes in intensity ( xref ), alongside (ii) longer endocytic events that were much brighter and took much longer ( xref )."
sparser
"If TORC2 does indeed phosphorylate Myo1, it would be important to know, first, whether TORC2 function is elevated in meiotic cells compared to mitotic cells and, second, what the effect of different growth conditions (vegetative, sexual, and nutrient limiting) is on the association of Myo1 with Cam1 vs. Cam2 as assessed via co-immunoprecipitations."
sparser
"The gene NCAN , a CNS-specific extracellular matrix protein whose expression has been linked to malignant behavior of neuroblastoma, xref and additional genes encoding cell surface proteins relevant for adhesion of neurons and leukocytes ( DSCAML1 , MAD-CAM1 ) also correlated significantly with OMAS neuroimmune symptoms."
sparser
"Throughout foetal development in mice, chemokines such as CXCL12 and -13, CCL19, -20 and -21, and adhesion molecules including vascular cell adhesion molecule 1 (VCAM-1), mucosal vascular addressing cell adhesion molecule 1 (MAD-CAM1) and intercellular adhesion molecule 1 (ICAM-1), altogether signal to promote the circulation of LTi cells and the migration of T- and B-lymphocytes into primordia resembling Peyer’s patches (Kunkel et al. xref ; Patel et al. xref )."
sparser
"Moreover, hypersialylation promotes tumor dissemination and metastasis by modulating the function of different integrins. xref For example, inhibiting sialylation in MM impairs interactions between tumor cells, VCAM1 and mucosal vascular addressin cell adhesion molecule 1 (MAD-CAM1) by altering the maturation of CD49d. xref Sialylation also participates in the generation of selectin ligands."
sparser
"These ligands include PSGL-1, the hemopoietic stem cell marker CD34, glycosylation-dependent cell adhesion molecule 1 (GlyCAM1) and mucosal addressin cell adhesion molecule 1 (MAd-CAM1), all of which contain a sulphated form of the sLe x tetrasaccharide. xref - xref However, there are other selectin ligands that occur naturally in humans which do not contain sLe x , the similar tetrasaccharide sLe a , nor structurally related carbohydrate moieties."
sparser
"The expression of some adhesion molecules on BM mononuclear cells was assessed by a panel
of MoAbs directed against: CD1 la, CDI lb, CDI lc, CD44, CD49d(VLA4), CD49e(VLA-5), LEC-CAM I.
P-170 expression
P-170 expression was evaluated by the MoAb C219 (Cis International, Centocor Diagnostics), which is an IgG2b antibody that recognizes a cytoplasmic antigen."
sparser
"The N-terminal domain (aa 22–138) of CALM contains the ANTH domain, which specifically binds to lipids (PtdIns(4,5)P 2 ) in the plasma membrane. xref , xref , xref , xref The three-dimensional structure of the N-terminal 280 amino acids of CALM has been solved and consists of 10 α-helices, which aggregate to form a globular protein. xref The C-terminal half of CALM, on the other hand, has most likely a poorly ordered structure that contains multiple short protein interaction motifs, functioning like a flexible ‘fishing line'. xref This composition of CALM permits the establishment of interactions during clathrin-coated pit assembly. xref Interestingly, FHL2 binds to β-integrin, xref which together with clathrin, a major binding partner of CALM, has been shown to be involved in endocytosis. xref , xref Taken together, these data suggest a role for the CALM–FHL2 interaction in the complex interaction network in endocytosis."
CALM1 affects DRG
|
9
Valproic acid affects CALM1
8
|
sparser
"These values were significantly higher than those obtained from the zero-order model (0.5145 ± 0.014, 0.6242 ± 0.011, 0.5751 ± 0.024, and 0.4150 ± 0.10 for CAM gel, CAM-BE gel, CAM-ES gel, and CAM-SOL, respectively) and the Higuchi diffusion model (0.8081 ± 0.096, 0.8475 ± 0.017, 0.8203 ± 0.035, and 0.7240 ± 0.016, respectively)."
sparser
"According to xref , the results showed that after 36 h, the amount of CAM that penetrated the CAM-BE gel formulation was considerably (P<0.001) higher, at 154.37 ± 3.92 μg/cm 2 compared to 101.38 ± 2.79 μg/cm 2 , 136.02 ± 3.35 μg/cm 2 and 129.08 ± 5.10 μg/cm 2 obtained from CAM gel, CAM-ES gel and CAM-SOL."
sparser
"The higher deposition showed that CAM-BE gel accumulated for a longer period of time in the skin, serving as a reservoir and permitting CAM to function for an extended period of time at the nearby tissue of the skin’s deep layers in between treatments. xref , xref When compared to both CAM gel and CAM-SOL, the ethosomes’ ethanol, phospholipid, and edge activator considerably enhanced CAM penetration and epidermal deposition, according to earlier experimental findings."
sparser
"Related studies have shown that it is of quite interest to study the changes in lipid CH 2 in the stratum corneum, xref and the literature suggests that the position of the peaks in the spectra is due to the stretching vibrations of SC lipids, and the (-CH 2 ) asymmetric stretching vibration band of the treated skin in the PBS group appeared at 2926.31 cm −1 , which shifted to higher wave numbers after the CAM-SOL and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2927.56 cm −1 , 2929.49 cm −1 and 2940.60 cm −1 ), respectively."
sparser
"The Area 2850 peak’s decline indicated that the sample had an impact on the stratum corneum that included lipid extraction. xref Additionally, the peak’s shift to a higher wavenumber suggested that the stratum corneum’s intercellular lipid problem had increased and the CH 2 symmetric (2850 cm −1 ) vibration band of the treated skin in the CAM-SOL group appeared at 2854.27 cm −1 , which shifted to higher wave numbers after the PBS and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2853.31 cm −1 , 2852.34 cm −1 , and 2850.85 cm −1 ), respectively."
Capsid protein affects CALM1
|
8
Capsid protein binds CALM1. 8 / 8
|
8
sparser
"Compared to a cryo-EM analysis of CAM-bound capsids that mostly revealed that CAM induced Cp tertiary and quaternary structural changes, the crystallography of CpY132A heximers revealed a more detailed interaction of the CAM molecule with amino acid residues of Cp at the HAP pocket due to an improved resolution [ xref , xref ]."
sparser
"In our initial efforts to achieve this goal, we compared three computational chemistry methods for their ability to predict a panel of 35 naturally occurring Cp mutations that may confer resistance to representative CAM-A and CAM-E compounds with all the crystal or CryoEM structures of CAM-bound HBV capsids or CpY132 hexamers available in the protein database."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
PCL affects CALM1
|
8
sparser
"As previously shown, the drug
release kinetics into 10 mL 1 × PBS differ between the two wound
dressings, although no differences in the disk diffusion assay (release
into the gel) were seen. xref Interestingly,
previously reported biofilm assays revealed that the CAM-PCL dressing
was more effective compared with the CAM-PCL/PEO dressing on E. coli CFT073, most likely due to the different
release kinetics. xref In the current assay,
both formulations with the same drug load exhibited a similar antibiofilm
effect, as a 6-log difference was observed in bacterial numbers for E. coli and S. epidermidis ( xref A,C)."
sparser
"As shown before for the CAM-PCL/PEO
dressing, 90% of the drug is released in the first 60 min, but for
the CAM-PCL dressing, the amount of drug released is only 40% after
24 h and up to 50% after 48 h. xref Therefore,
the available drug concentration after 24 h of treatment is different,
being higher when using the CAM-PCL/PEO dressing."
sparser
"Drug encapsulation
can either increase or decrease the mechanical
properties of electrospun PCL fibers. xref , xref It has been
shown that incorporation of the antibacterial drug linezolid into
PCL scaffolds improved their mechanical properties. xref It is known that drug–polymer interactions affect
the mechanical properties of electrospun polyester fibers, xref and as the solid-state analyses in our previous
study have revealed, different solvents may have affected the CAM–PCL
interactions at the molecular level differently. xref This may lead to different mechanical behavior of scaffolds."
sparser
"The ES solution compositions,
conditions, and method parameters of all four different types of wound
dressings (two pristine PCL and PCL/PEO dressings and two antibacterial
drug CAM-loaded CAM-PCL and CAM-PCL/PEO dressings) have been previously
published by Preem et al. In brief, ES solutions were prepared by
dissolving the polymer PCL 12.5% (w/V) alone or PCL 10% (w/V) together
with PEO 2% (w/V) in a chloroform/methanol (CHF/MET) (3:1 V/V) solvent
mixture."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
sparser
"Our investigations show no response to LFA-1/ICAM-1 alone, but that costimulation by LFA-1/CAM-1 interaction induces prolonged inositol phospholipid hydrolysis (up to 4 h), resulting in generation of both inositol(1,4,5)phosphate3 and inositol(1,3,4,5)phosphate4 and their derivatives."
sparser
"A = lack of M H C classI antigen expression by tumour cells permitting escape from cytolytic T-cells;
B=sheddingofI-CAM-1 into circulation may block T-cell receptors for this molecule and prevent tumour cell/cytolytic cell interactions; C=Tcells binding to classI antigen and D = stabilisation in association with I-CAM-1/LFA-1 interaction."
reach
"These results indicated that SUMOylation of Kv7.2 and Kv7.3 specifically regulates their binding with CaM1.To verify the role of SUMOylation of Kv7.2 and Kv7.3 in their binding with CaM1, these plasmids were transfected with SUMO2, and the co-IP results showed that SUMO2 significantly enhanced the binding of both Kv7.2 and Kv7.3 with CaM1 (Fig. 4F)."
HR affects CALM1
|
8
sparser
"For examples, two particular CAMS, the Gradient Weighted CAM (Grad-CAM) and High Resolution CAM (HR-CAM) have been shown to provide insights into the process of AI decision-making for oral cancer and other cancer types, with improved diagnostic performance and positive user feedback ( xref – xref )."
sparser
"Specifically, Grad-CAM generates heatmaps by computing the gradients of the target class score with respect to the feature maps of the last convolutional layers in the CNN while HR-CAM aggregates feature maps from several layers to create a high-resolution localization map ( xref )."
sparser
"These values were significantly higher than those obtained from the zero-order model (0.5145 ± 0.014, 0.6242 ± 0.011, 0.5751 ± 0.024, and 0.4150 ± 0.10 for CAM gel, CAM-BE gel, CAM-ES gel, and CAM-SOL, respectively) and the Higuchi diffusion model (0.8081 ± 0.096, 0.8475 ± 0.017, 0.8203 ± 0.035, and 0.7240 ± 0.016, respectively)."
sparser
"According to xref , the results showed that after 36 h, the amount of CAM that penetrated the CAM-BE gel formulation was considerably (P<0.001) higher, at 154.37 ± 3.92 μg/cm 2 compared to 101.38 ± 2.79 μg/cm 2 , 136.02 ± 3.35 μg/cm 2 and 129.08 ± 5.10 μg/cm 2 obtained from CAM gel, CAM-ES gel and CAM-SOL."
sparser
"The higher deposition showed that CAM-BE gel accumulated for a longer period of time in the skin, serving as a reservoir and permitting CAM to function for an extended period of time at the nearby tissue of the skin’s deep layers in between treatments. xref , xref When compared to both CAM gel and CAM-SOL, the ethosomes’ ethanol, phospholipid, and edge activator considerably enhanced CAM penetration and epidermal deposition, according to earlier experimental findings."
sparser
"Related studies have shown that it is of quite interest to study the changes in lipid CH 2 in the stratum corneum, xref and the literature suggests that the position of the peaks in the spectra is due to the stretching vibrations of SC lipids, and the (-CH 2 ) asymmetric stretching vibration band of the treated skin in the PBS group appeared at 2926.31 cm −1 , which shifted to higher wave numbers after the CAM-SOL and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2927.56 cm −1 , 2929.49 cm −1 and 2940.60 cm −1 ), respectively."
sparser
"The Area 2850 peak’s decline indicated that the sample had an impact on the stratum corneum that included lipid extraction. xref Additionally, the peak’s shift to a higher wavenumber suggested that the stratum corneum’s intercellular lipid problem had increased and the CH 2 symmetric (2850 cm −1 ) vibration band of the treated skin in the CAM-SOL group appeared at 2854.27 cm −1 , which shifted to higher wave numbers after the PBS and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2853.31 cm −1 , 2852.34 cm −1 , and 2850.85 cm −1 ), respectively."
CALM1 affects endocytosis
|
6
2
CALM1 activates endocytosis.
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6
CALM1 activates endocytosis. 6 / 6
|
6
reach
"The fact that this process takes place only in the case of multimeric ligands incubated with cells at 37degreesC, but not at 4degreesC, indicates that CAM mediated endocytosis is an active process, with close similarities to typical receptor mediated endocytosis (Muro et al., 2008)."
reach
"Recent studies by Muro et al. [35,37] revealed that to internalise anti-ICAM and anti-PECAM conjugates via constitutively non internalisable determinants ECs employ a novel, previously unknown internalisation pathway, which differs from clathrin- and caveoli mediated endocytosis and CAM mediated endocytosis."
CALM1 inhibits endocytosis.
|
2
CALM1 inhibits endocytosis. 2 / 2
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2
sparser
"Although the presence of this domain was required for CALM-AF10 to inhibit transferrin endocytosis in a transfected human cell line, internalization of growth factor receptors and their signaling was not affected in leukemia cells lines or in primary leukemia cells isolated from mice transplanted with cells transduced with CALM-AF10."
CALM1 affects capsid protein
|
8
Capsid protein binds CALM1. 8 / 8
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8
sparser
"Compared to a cryo-EM analysis of CAM-bound capsids that mostly revealed that CAM induced Cp tertiary and quaternary structural changes, the crystallography of CpY132A heximers revealed a more detailed interaction of the CAM molecule with amino acid residues of Cp at the HAP pocket due to an improved resolution [ xref , xref ]."
sparser
"In our initial efforts to achieve this goal, we compared three computational chemistry methods for their ability to predict a panel of 35 naturally occurring Cp mutations that may confer resistance to representative CAM-A and CAM-E compounds with all the crystal or CryoEM structures of CAM-bound HBV capsids or CpY132 hexamers available in the protein database."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
CALM1 affects PCL
|
8
sparser
"As previously shown, the drug
release kinetics into 10 mL 1 × PBS differ between the two wound
dressings, although no differences in the disk diffusion assay (release
into the gel) were seen. xref Interestingly,
previously reported biofilm assays revealed that the CAM-PCL dressing
was more effective compared with the CAM-PCL/PEO dressing on E. coli CFT073, most likely due to the different
release kinetics. xref In the current assay,
both formulations with the same drug load exhibited a similar antibiofilm
effect, as a 6-log difference was observed in bacterial numbers for E. coli and S. epidermidis ( xref A,C)."
sparser
"As shown before for the CAM-PCL/PEO
dressing, 90% of the drug is released in the first 60 min, but for
the CAM-PCL dressing, the amount of drug released is only 40% after
24 h and up to 50% after 48 h. xref Therefore,
the available drug concentration after 24 h of treatment is different,
being higher when using the CAM-PCL/PEO dressing."
sparser
"Drug encapsulation
can either increase or decrease the mechanical
properties of electrospun PCL fibers. xref , xref It has been
shown that incorporation of the antibacterial drug linezolid into
PCL scaffolds improved their mechanical properties. xref It is known that drug–polymer interactions affect
the mechanical properties of electrospun polyester fibers, xref and as the solid-state analyses in our previous
study have revealed, different solvents may have affected the CAM–PCL
interactions at the molecular level differently. xref This may lead to different mechanical behavior of scaffolds."
sparser
"The ES solution compositions,
conditions, and method parameters of all four different types of wound
dressings (two pristine PCL and PCL/PEO dressings and two antibacterial
drug CAM-loaded CAM-PCL and CAM-PCL/PEO dressings) have been previously
published by Preem et al. In brief, ES solutions were prepared by
dissolving the polymer PCL 12.5% (w/V) alone or PCL 10% (w/V) together
with PEO 2% (w/V) in a chloroform/methanol (CHF/MET) (3:1 V/V) solvent
mixture."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
sparser
"Our investigations show no response to LFA-1/ICAM-1 alone, but that costimulation by LFA-1/CAM-1 interaction induces prolonged inositol phospholipid hydrolysis (up to 4 h), resulting in generation of both inositol(1,4,5)phosphate3 and inositol(1,3,4,5)phosphate4 and their derivatives."
sparser
"A = lack of M H C classI antigen expression by tumour cells permitting escape from cytolytic T-cells;
B=sheddingofI-CAM-1 into circulation may block T-cell receptors for this molecule and prevent tumour cell/cytolytic cell interactions; C=Tcells binding to classI antigen and D = stabilisation in association with I-CAM-1/LFA-1 interaction."
reach
"These results indicated that SUMOylation of Kv7.2 and Kv7.3 specifically regulates their binding with CaM1.To verify the role of SUMOylation of Kv7.2 and Kv7.3 in their binding with CaM1, these plasmids were transfected with SUMO2, and the co-IP results showed that SUMO2 significantly enhanced the binding of both Kv7.2 and Kv7.3 with CaM1 (Fig. 4F)."
CALM1 affects HR
|
8
sparser
"For examples, two particular CAMS, the Gradient Weighted CAM (Grad-CAM) and High Resolution CAM (HR-CAM) have been shown to provide insights into the process of AI decision-making for oral cancer and other cancer types, with improved diagnostic performance and positive user feedback ( xref – xref )."
sparser
"Specifically, Grad-CAM generates heatmaps by computing the gradients of the target class score with respect to the feature maps of the last convolutional layers in the CNN while HR-CAM aggregates feature maps from several layers to create a high-resolution localization map ( xref )."
sparser
"An AR based system for enhancing spatial awareness and comprehension problems for engineering graphics education was designed (Chen et al 2011) . (Yan et al 2011) worked on an prototype for integrating Building Information Modeling (BIM) (providing geometric and alphanumeric information), and gaming to improve architectural visualization. (Pena 2014 ) researched a graphical application for tablet computers that supports 2D computer graphics and interaction for two-fold use: a teaching lab module and stand-alone instructional tool. (Shirazi and Behzadan 2015b) designed and assessed the effectiveness of a collaborative context-aware mobile augmented reality tool (CAM-ART) for the civil engineering curriculum. (Turkan et al 2017) designed and developed an AR application and run it in a pilot study at a junior level structural analysis class to assess the pedagogical impact and the design concepts employed by the AR tool."
| DOI
sparser
"An AR based system for enhancing spatial awareness and comprehension problems for engineering graphics education was designed (Chen et al 2011) . (Yan et al 2011) worked on an prototype for integrating Building Information Modeling (BIM) (providing geometric and alphanumeric information), and gaming to improve architectural visualization. (Pena 2014 ) researched a graphical application for tablet computers that supports 2D computer graphics and interaction for two-fold use: a teaching lab module and stand-alone instructional tool. (Shirazi and Behzadan 2015b) designed and assessed the effectiveness of a collaborative context-aware mobile augmented reality tool (CAM-ART) for the civil engineering curriculum. (Turkan et al 2017) designed and developed an AR application and run it in a pilot study at a junior level structural analysis class to assess the pedagogical impact and the design concepts employed by the AR tool."
| DOI
Hsa-miR-7-5p affects CALM1
7
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Hsa-miR-450b-5p affects CALM1
7
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Hsa-miR-3680-3p affects CALM1
7
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Hsa-miR-1-3p affects CALM1
7
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TS affects CALM1
|
7