IndraLab
Statements
sparser
"Five more groups (n= 10) were light-cured in a natural tooth mold from two sites (labial and lingual) through a nanohybrid resin composite CAD-CAM restoration (Lava Ultimate A2 LT), for different irradiation times: 90 seconds per site, 40 seconds per site, 30 seconds per site, 20 seconds per site and 10 seconds per site."
sparser
"The HET-CAM test revealed that Soluplus and Pluronic F68 micelle dispersions behaved as the negative control (0.9% NaCl) without inducing bleeding, lysis or coagulation at the time of the study ( t H , t L , and t C > 301 s; IS = 0), which means that they can be considered non-irritants ( xref )."
CALM1 binds Multiple Myeloma and Dr. 4 / 4
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4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
sparser
"We found that stability estimates from the Cam-CAN data were unaffected by the length of raw recordings used for pre-processing and source imaging, as data lengths from 60 s to 150 s (tested in increments of 30 s) indicated no meaningful difference in stability from the full length (480 s) version in all frequencies except high-gamma ( xref )."
sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [ xref ], Collation of Connectivity Data for the Macaque (CoCoMac) database [ xref ] and Human Connectome Project (HCP) [ xref ], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [ xref ], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [ xref ], the National Alzheimer’s Coordinating Center (NACC) [ xref ], UK Biobank [ xref ] and the Dementias Platform UK (DPUK) [ xref ]."
GO affects CALM1
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77
CALM1 is modified
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39
4
CALM1 is phosphorylated.
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14
4
CALM1 is glycosylated.
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14
sparser
"In addition, studies in our laboratories have been performed and are still in progress, mainly aimed to elucidate the expression and significance of the CAM glycosylation patterns, as well as to identify and characterize membrane molecular components implicated in the ion transport processes which occur in the chorionic epithelium [ xref – xref ]."
CALM1 is methylated.
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8
sparser
"The recently completed genome of pineapple has and will continue to facilitate many areas of research in this species, and the present work focuses on the regulatory impact of DNA methylation on CAM pathway-related genes using temporal and spatial methylome and transcriptome analysis."
sparser
"The results showed CALM1 methylation to be significantly increased in cervical and endocervical cancer (CESC) and COAD compared with that in normal tissues, but significantly decreased in LIHC and PCPG ( xref ), showing an inverse trend compared with that of the expression pattern."
CALM1 is acetylated.
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3
EP affects CALM1
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39
sparser
"This suggests that delirium screening can be performed efficiently by nurses and CNAs operating within their scope of practice, using for example the nurse two-step protocol with skip (UB-CAM), or the CNA UB-2 followed by nurse 3D-CAM with skip (not explicitly tested in our study)."
sparser
"The UB-2 can effectively rule out delirium in less than 40 seconds, with a 93% sensitivity in persons with and without dementia. xref , xref If the person correctly answers both items in the UB-2, the protocol is complete; if not, the 3D-CAM is administered as step two. xref , xref The 3D-CAM is a validated diagnostic interview for delirium that can be completed in three minutes. xref We refer to this two-step process as the UB-CAM. (See xref , xref , xref )"
sparser
"This study describes the barriers and facilitators related to the implementation of the Ultra-brief Confusion Assessment Method (UB-CAM), a rapid two-step delirium identification protocol (ultra-brief screen, followed by CAM in positives), field tested with hospitalized older adults (70+)."
sparser
"Herein, we propose a sandwich-type surface enhanced Raman scattering (SERS) immuno-nanosensor which is aimed for detecting and quantifying Carcinoembryonic antigen-related cell adhesion molecule 5 (CEA-CAM5), a protein involved in intercellular adhesion and signaling pathways that acts as a tumor marker in several types of cancer."
sparser
"These could not be explained by higher sensibility of the IL-33 KO mouse strain as the expression of the basic receptors described to be involved in the infectivity such as CEA-CAM [27] , TLR2 [22, 28] , and TLR3 [29] receptors were expressed at a comparable level in WT and IL-33 KO mice."
sparser
"In mammals, CEACAM families consist of a group of orthologous members (CEACAM16, CEACAM18, CEA-CAM19, CEACAM20) where counterparts can be clearly assigned in different species and a group of paralogous members which are most closely related to CEACAM1 within the same species [3] ."
sparser
"The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (gene:vWF), Jagged 1 (gene:JAG1), Laminin subunit alpha 2 (gene:LAMA2), Thrombospondin-2 (gene:TSP2), and Collagen IV (gene:COL4)) but do not recognize specific proteins such as Bovine serum albumin (gene:BSA) and human Thrombospondin-1 (gene:TSP1), Biglycan (gene:BGN) and Decorin (gene:DCN)."
sparser
"Of the antibodies identified by ELISA, we found by dot blotting that two rabbit IgG monoclonals (4E7 and 52H11) bound to the CAM-cys modified MYADML2 peptides but were incapable of binding to peptides lacking CAM-cys modifications (peptide sequences shown in xref ; blots shown in xref [probed with 4E7],1C [with 52H11], and 1D [with secondary antibody alone])."
CALM1 affects calcium(2+)
2
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18
CALM1 binds calcium(2+).
2
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9
Calcium(2+) binds CALM1. 10 / 19
2
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9
reach
"These marker proteins are listed in Table S-6 and include for instance calmodulin-1, MARCS, and the peptidyl-prolyl cis-trans isomerase FKBP9, which bind calcium; proteins with chaperone function (CH60, HSPB1, PRS4, and TCPA); components of the nuclear lamina (LMNA, LMNB1), as well as an interferon-induced GTP-binding protein (MX1); and vimentin, a class III intermediate filament."
"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the EF hands in each domain and dramatically changes the two domains of CaM to produce more open conformations"
CALM1 activates calcium(2+).
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5
CALM1 inhibits calcium(2+).
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4
sparser
"The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (gene:vWF), Jagged 1 (gene:JAG1), Laminin subunit alpha 2 (gene:LAMA2), Thrombospondin-2 (gene:TSP2), and Collagen IV (gene:COL4)) but do not recognize specific proteins such as Bovine serum albumin (gene:BSA) and human Thrombospondin-1 (gene:TSP1), Biglycan (gene:BGN) and Decorin (gene:DCN)."
sparser
"Of the antibodies identified by ELISA, we found by dot blotting that two rabbit IgG monoclonals (4E7 and 52H11) bound to the CAM-cys modified MYADML2 peptides but were incapable of binding to peptides lacking CAM-cys modifications (peptide sequences shown in xref ; blots shown in xref [probed with 4E7],1C [with 52H11], and 1D [with secondary antibody alone])."
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S110. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S280. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S172. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S53, S177, and S213 on S274. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, and S213 on S177. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S326, S180, S268, S274, S53, S177, and S213 on S221. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S274, S53, S177, and S213 on S268. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S221, S326, S180, S268, S274, S53, S177, and S213 on S175. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S171. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S174. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S217. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, and S177 on S213. 2 / 2
2
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CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S268, S274, S53, S177, and S213 on S180. 2 / 2
2
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CALM1 affects B3LYP
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25
sparser
"For Fe–Fe/Mo–Fe distances,
CAM-B3LYP gives worse deviations for both spin-coupled (and diamagnetic
complexes) than its parent B3LYP functional with MD = +0.061 Å
(MAD 0.067 Å) and the recent ωB97M-D3BJ functional (found
to be highly accurate for main group thermochemistry) xref , xref offers no improvement either, with MD of +0.067 Å (MAD = 0.067
Å)."
sparser
"The rate-determining
step can be either the bond rotation or the proton transfer, depending
on the rotating bond and the meso -substituents. xref , xref For this particular switch, several density functionals were benchmarked
against CCSD(T)/6-31G data, concluding that both CAM-B3LYP and M05-2X
provide the most reliable results. xref Besides
the Hückel–Möbius interconversion, we also considered
the switching from 28M to 28F with the associated
transition state ( 28TS 3 ), as
shown in."
Calcium(2+) affects CALM1
5
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11
Calcium(2+) binds CALM1.
2
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9
Calcium(2+) binds CALM1. 10 / 19
2
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9
reach
"These marker proteins are listed in Table S-6 and include for instance calmodulin-1, MARCS, and the peptidyl-prolyl cis-trans isomerase FKBP9, which bind calcium; proteins with chaperone function (CH60, HSPB1, PRS4, and TCPA); components of the nuclear lamina (LMNA, LMNB1), as well as an interferon-induced GTP-binding protein (MX1); and vimentin, a class III intermediate filament."
"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the EF hands in each domain and dramatically changes the two domains of CaM to produce more open conformations"
Calcium(2+) activates CALM1.
3
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2
Calcium(2+) activates CALM1. 5 / 5
3
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2
"Except for nfat5, nfatc1c4 are activated upon a rise in intracellular ca2+, which stimulates the serine/threonine phosphatase activity of calcineurin the ca2+-calcineurin signal is the most important signal for regulating nfat activation, but the signal that leads to ca2+ influx during neural tube differentiation is still unclear."
"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the EF hands in each domain and dramatically changes the two domains of CaM to produce more open conformations"
sparser
"For example, activity of the core AJ components E-cadherin (E-cad) and α-catenin (α-cat) has been linked to activation of the core Hippo kinase LATS1/2 and inhibition of YAP ( xref ; xref ; xref ), and in Drosophila the Ig-CAM protein Echinoid that localizes to AJs can promote Salvador/Hpo activity to inhibit Yki ( xref )."
sparser
"Transmembrane protein P0 is an immunoglobulin-like cell adhesion molecule (Ig-CAM) and mediates the adhesion of the extracellular myelin surfaces. xref , xref , xref Periaxin is the second most abundant protein in PNS myelin and is a scaffolding protein. xref , xref , xref Periaxin is expressed before P0, MBP, or MAG and is suggested to play an important role during ensheathment and myelination in the PNS. xref In the CNS and PNS, MBP accounts for 8% of the myelin proteins and mediates the intracellular adhesion of cytoplasmic surfaces between individual layers of compact myelin. xref , xref , xref MBP is a highly heterogeneous protein as a result of alternative splicing and posttranslational modifications such as N-terminal acylation, GTP- and ADP-ribose binding sites, deamidation, methylated arginine, methionine sulfoxide, phosphorylation, and deimination of arginyl residues. xref , xref In the CNS of shiverer mutant mice, which do not express MBP, major dense lines are missing."
sparser
"They contain a furin-like cleavable domain and transmembrane domains, i.e., C-terminal TM-1 and cytoplasmic tail. (f) Membrane-type MMPs, including MMP-17 and MMP-25, resemble archetypal MMPs and contain a C-terminal glycosylphosphatidylinositol (GPI) membrane anchor. (g) Other MMPs (MMP-23A and MMP-23B) also resemble archetypal MMPs, lack a hemopexin domain and contain N-terminal TM-II and cytoplasmic C-terminal immunoglobulin-like cell adhesion molecule (Ig-CAM) domains [ xref , xref ]."
sparser
"Considering that quantification of the most abundant myelin proteins requires a high dynamic range ( xref ; xref ), we calculated the relative abundance of the 562 proteins identified in zebrafish myelin by MS E . According to this dataset, the most abundant zebrafish myelin proteins are myelin basic protein (MBPa), the Ig-CAM myelin protein zero (MPZa), the short-chain dehydrogenase 36K (also termed DHRS12), MPZb, and the complement inhibitor CD59, which respectively, constitute 7.6%, 7.3%, 6.3%, 4.7%, and 4.6% of the total myelin protein ( xref )."
sparser
"This triggers the activation of integrins from the cancer cells allowing their firmer adhesion to members of the Ig‐CAM family such as ICAM and VCAM‐1, initiating the transendothelial migration and therefore the extravasation process. xref VCAM‐1 is therefore thought to play a key role in the process of malignant progression and its presence studied in terms of impact on cell migration. xref "
sparser
"For example, activity of the core AJ components E-cadherin (E-cad) and α-catenin (α-cat) has been linked to activation of the core Hippo kinase LATS1/2 and inhibition of YAP ( xref ; xref ; xref ), and in Drosophila the Ig-CAM protein Echinoid that localizes to AJs can promote Salvador/Hpo activity to inhibit Yki ( xref )."
sparser
"Transmembrane protein P0 is an immunoglobulin-like cell adhesion molecule (Ig-CAM) and mediates the adhesion of the extracellular myelin surfaces. xref , xref , xref Periaxin is the second most abundant protein in PNS myelin and is a scaffolding protein. xref , xref , xref Periaxin is expressed before P0, MBP, or MAG and is suggested to play an important role during ensheathment and myelination in the PNS. xref In the CNS and PNS, MBP accounts for 8% of the myelin proteins and mediates the intracellular adhesion of cytoplasmic surfaces between individual layers of compact myelin. xref , xref , xref MBP is a highly heterogeneous protein as a result of alternative splicing and posttranslational modifications such as N-terminal acylation, GTP- and ADP-ribose binding sites, deamidation, methylated arginine, methionine sulfoxide, phosphorylation, and deimination of arginyl residues. xref , xref In the CNS of shiverer mutant mice, which do not express MBP, major dense lines are missing."
sparser
"They contain a furin-like cleavable domain and transmembrane domains, i.e., C-terminal TM-1 and cytoplasmic tail. (f) Membrane-type MMPs, including MMP-17 and MMP-25, resemble archetypal MMPs and contain a C-terminal glycosylphosphatidylinositol (GPI) membrane anchor. (g) Other MMPs (MMP-23A and MMP-23B) also resemble archetypal MMPs, lack a hemopexin domain and contain N-terminal TM-II and cytoplasmic C-terminal immunoglobulin-like cell adhesion molecule (Ig-CAM) domains [ xref , xref ]."
sparser
"Considering that quantification of the most abundant myelin proteins requires a high dynamic range ( xref ; xref ), we calculated the relative abundance of the 562 proteins identified in zebrafish myelin by MS E . According to this dataset, the most abundant zebrafish myelin proteins are myelin basic protein (MBPa), the Ig-CAM myelin protein zero (MPZa), the short-chain dehydrogenase 36K (also termed DHRS12), MPZb, and the complement inhibitor CD59, which respectively, constitute 7.6%, 7.3%, 6.3%, 4.7%, and 4.6% of the total myelin protein ( xref )."
sparser
"This triggers the activation of integrins from the cancer cells allowing their firmer adhesion to members of the Ig‐CAM family such as ICAM and VCAM‐1, initiating the transendothelial migration and therefore the extravasation process. xref VCAM‐1 is therefore thought to play a key role in the process of malignant progression and its presence studied in terms of impact on cell migration. xref "
sparser
"While N exon nucleotide sequences of CEACAM16, CEACAM18, CEA-CAM19 and CEACAM20 from different species cluster together, all other CEACAM N domain exon sequences of a given species are most closely related with the corresponding CEACAM1 sequence of that species, indicating that these genes were generated independently by multiple rounds of duplication of an ancestral CEA-CAM1 gene possibly followed by gene conversion events ( Figure 1A )."
sparser
"The following oligonucleotide primers that detect murine CEA-CAM1 isoforms were used for detection: mouse CEACAM1, a common sense primer that detects both long and short isoform FP-5 0 -GCCATGCAGCCTCTA ACCCACC-3 0 ; and two antisense primers that detect specific isoforms, mouse CEACAM1-L BP-5 0 -CTGGAGGTTGAGGGTTTGTGCTC-3 0 and mouse CEA-CAM1-S BP-5 0 -TCAGAAGGAGCCAGACCCGCC-3 0 ."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"Additionally, CR can act on the genes of the upstream pathway, such as IL1B and TNF, which are proinflammatory mediators [ xref , xref ], while ATR can act on downstream genes, such as CALM1 and NOS3, which are associated with learning and memory and anti-inflammatory processes."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"While N exon nucleotide sequences of CEACAM16, CEACAM18, CEA-CAM19 and CEACAM20 from different species cluster together, all other CEACAM N domain exon sequences of a given species are most closely related with the corresponding CEACAM1 sequence of that species, indicating that these genes were generated independently by multiple rounds of duplication of an ancestral CEA-CAM1 gene possibly followed by gene conversion events ( Figure 1A )."
sparser
"The following oligonucleotide primers that detect murine CEA-CAM1 isoforms were used for detection: mouse CEACAM1, a common sense primer that detects both long and short isoform FP-5 0 -GCCATGCAGCCTCTA ACCCACC-3 0 ; and two antisense primers that detect specific isoforms, mouse CEACAM1-L BP-5 0 -CTGGAGGTTGAGGGTTTGTGCTC-3 0 and mouse CEA-CAM1-S BP-5 0 -TCAGAAGGAGCCAGACCCGCC-3 0 ."
sparser
"These results suggest that in vitro binding of TCF4B and CaM or CaM1,2,3,4 can occur independently of Ca 2+ binding, but that in vivo CaM-dependent prevention of pyramidal cell aggregation by TCF4B gain of function requires Ca 2+ , because the Ca 2+ insensitive CaM1,2,3,4 was ineffective at rescuing cellular aggregation."
sparser
"These same resonances are exchange broadened in CaM bound to the CNGB1 CaM1 peptide (Bej and Ames xref ) and the α-subunit of the retinal cyclic nucleotid