IndraLab

Statements


CALM1 affects ACOD1
| 937
| 937

sparser
"Effect of endodontic access simulation on the fracture strength of lithium-disilicate and resin-matrix ceramic CAD-CAM crowns."

sparser
"In the sagittal plane, modern braces seem to be more effective than traditional braces, but there is an ongoing debate among clinicians, about which CAD-CAM and CAD-FEM brace provides a better treatment outcome."

sparser
"The introduction of computer-aided design and computer-aided manufacturing (CAD-CAM) technology for complete denture fabrication may have improved clinical outcomes compared with conventional techniques."

sparser
"Interim crowns fabricated by CAD-CAM system are better suited for temporization."

sparser
"A clear consensus as to which finish line design can provide a better marginal and internal adaptation with respect to cobalt-chromium metal alloy copings fabricated by using computer-aided design and computer-aided manufacturing (CAD-CAM) technology is lacking."

sparser
"This article describes a technique for recording the maxilla's orientation in esthetically driven oral rehabilitation and transferring its position by using computer-aided design and computer-aided manufacturing (CAD-CAM) technology."

sparser
"Accurate fit of restorations is extremely essential to achieve acceptable longevity. xref The presence of discrepancies at the crown margins favors plaque accumulation and microleakage, dissolution of cement, leading to secondary caries and periodontal disease. xref Multiple studies have assessed the marginal fit and adaptation of CAD-CAM restorations. xref It is suggested that the marginal accuracy of restorations made with CAD-CAM systems may be influenced by the designing software’s and parameters. xref "

sparser
"They observed the lowest surface roughness in CAD-CAM PMMA blocks."

sparser
"Twenty partially edentulous patients, with severe posterior mandibular atrophy, underwent a guided bone regeneration technique by means of customized CAD-CAM titanium mesh in association with a mixture of autologous bone in chips and deproteinized bovine bone (1:1)."

sparser
"Influence of thermomechanical aging on marginal gap of CAD-CAM and conventional interim restorations."
SAFB affects CALM1
| 231
| 231

sparser
"Various toxicity studies, such as Draize and low volume eye tests, and non-ocular models, such as hen’s egg test-chorioallantoic membrane (HET-CAM), have been developed to assess the safety of the formulations."
| PMC

sparser
"Polymyxin B-loaded hydrogels showed good biocompatibility in HET-CAM tests."
| PMC

sparser
"The Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) assay, corneal hydration study, and histopathology observation showed the non-irritancy of the developed SLN-6, most probably due to the use of physiological compatible lipid and excipients [ xref ]."

sparser
"These results are in agreement with the HET-CAM test confirming the non-irritant potential of DXI loaded polymeric nanoparticles and also the suitability of the HET-CAM test in order to mimic the in vivo irritation phenomena."

sparser
"In this respect, the chick embryo or hen's egg test-chorioallantoic membrane (HET-CAM) model is of special interest, as it is not considered an animal until day 17."

sparser
"HET-CAM study demonstrates that the formulation prepared is non irritant to the highly vascular tissues and hence can be used for the immunological sensitive tissues like inflamed intestine in IBD."

sparser
"We assayed the effects of venoms from the most widespread venomous African Bitis arietens and closely related species Bitis parviocula using The Hen's Egg Test-Chorioallantoic membrane test (HET-CAM) and Chicken embryotoxicity screening test (CHEST), acetylcholinesterase (AChE) analysis, cytotoxicity assay performed on cell lines and protein analysis of selected venoms."

sparser
"The relative safety of the optimized micelles on the ocular tissue was shown with the HET-CAM toxicity test."

sparser
"HET-CAM tests showed that none of the liposomes were irritating (Fig.  xref ), which is suitable for the ocular application."

sparser
"The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and hen's egg-chorioallantoic membrane test (HET-CAM) assays confirmed that the complexes and ocular films were nonirritant and safe for ocular administration."
Dr affects CALM1
| 157
| 151

sparser
"We hypothesized that a decreased level of extracellular COL3A1 resulted in reduced drug binding, increased drug diffusion into cells, and reduced interaction between ECM and cell surface receptors, resulting in reduced CAM-DR strength."

sparser
"Thus it will be critical to move toward a personalized approach for targeting the CAM-DR phenotype associated with cell adhesion as well as for inhibitors of soluble factors that confer drug resistanc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Thus, integrin-mediated chemoresistance is perceived as a form of adhesion-mediated drug resistance (CAM-DR) ( xref )."

sparser
"In this study, we investigated the mechanism of CAM-DR induced by Fibronectin (Fn)."

sparser
"As Wnt signaling has been shown to be an aberrantly upregulated pathway in leukemia ( xref ) and is involved with chemoresistance, this warrants further exploration of celecoxib as a viable therapy to reverse CAM-DR in leukemia."

sparser
"Strengthening our comprehension of miRNA production and activity in the MM cell−BM relationship will help us to identify novel drug targets to overwhelm CAM-DR [ xref , xref ]."
| PMC

sparser
"Intracellular signaling initiated by binding to the ECM seems to be fundamental for cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref ]."
| PMC

sparser
"VTD-PACE is a good option for EMD considering CAM-DR and hypoxia, but might be intolerable for the majority of patients with a terminal phase of MM [ xref ]."

sparser
"One of the resistance phenomena involved in MM is the cell adhesion mediated drug resistance (CAM-DR) [ xref , xref ]."
| PMC

sparser
"Different ECM proteins, including laminin and fibronectin, are associated with CAM-DR in different cancer types [ xref ], including pancreatic cancer [ xref ]."

sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."

sparser
"For example, anticancer drug-induced H3K27 hypermethylation is associated with CAM-DR in MM cells [ xref ]."

sparser
"Finally, we showed that the interaction of Numbl with integrin β1 promotes the formation of CAM-DR in MM cells."

sparser
"In summary, Numbl plays a significant role in the formation of CAM-DR in MM cells."
CALM1 binds DYRK2 and Dr. 2 / 2
| 2

sparser
"To determine whether DYRK2 was associated with CAM-DR in NHL cells, cell adhesion assay was performed to investigate the expression of DYRK2."

sparser
"In conclusion, our study demonstrated that DYRK2 was associated with the proliferation and CAM-DR of NHL cells."
NUP214 affects CALM1
| 107
| 107

sparser
"We used a large (N = 708) age-heterogeneous population-based sample from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), employing age-residualized measures of cognition, data-driven exploratory structural equation modelling and confirmatory factor analysis."

sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [ xref ], Collation of Connectivity Data for the Macaque (CoCoMac) database [ xref ] and Human Connectome Project (HCP) [ xref ], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [ xref ], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [ xref ], the National Alzheimer’s Coordinating Center (NACC) [ xref ], UK Biobank [ xref ] and the Dementias Platform UK (DPUK) [ xref ]."

sparser
"Age-Related Trends in Neuromagnetic Transient Beta Burst Characteristics During a Sensorimotor Task and Rest in the Cam-CAN Open-Access Dataset - Supplementary Information."

sparser
"For completeness, we also related motor adaptation to several other cognitive variables collected in Cam-CAN ( xref ), as shown in the xref ."

sparser
"The acquisition times of the Cam-CAN MT-weighted sequences were under 5 minutes, which would be more acceptable for translation to clinical populations such as AD and PD compared with the other studies that acquired MT-weighted images in over 12 minutes."

sparser
"The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) is a large-scale collaborative research project that aims to identify the neural mechanisms underlying successful aging in a population-based sample spanning the adult life span ( xref )."

sparser
"As was reported to be the case with the Dahl mask ( xref ), it was observed that the Cam-CAN LC mask did not extend as far caudally as did the Keren and Betts masks, explaining the relatively lower overlap with these masks (see xref )."

sparser
"These scans were obtained from an open-access database (Cam-CAN) that did not specifically use imaging parameters to investigate the LC and provide insights on how neuromelanin contrast and scanning parameters can be optimized for future studies."

sparser
"The Cam-CAN LC mask showed good overlap relative to the previously published Dahl mask volume (94%) and the rostral/middle portions of the Keren and Betts masks."

sparser
"Similarly, when identifying markers or developing interventions to support cognition, results from the Cam-CAN cohort highlight the need for a lifespan, targeted approach that builds on strengths as well as seeking to ameliorate decline."
USP9X affects CALM1
| 106
| 106

sparser
"We compared clinical outcomes in the 6-months after enrollment by FAM-CAM status."

sparser
"For family-based interventions, the following measures will be reported: cumulative time family members spent with patients, proportion of daily tasks (e.g., assistance with glasses/hearing aids, handwashing), successfully completed, length of time spent on stimulating activity, and overall agreement of the FAM-CAM with interview-rated CAM assessments."

sparser
"FAM-CAM, Family-based Confusion Assessment Method for delirium; PHQ, Patient Health Questionnaire; PROMIS, Patient-Reported Outcomes Measurement Information System."

sparser
"As such, the Family Confusion Assessment Method (FAM-CAM) was developed to screen for delirium by interviewing family caregivers."

sparser
"Similarly, missing CAM and FAM-CAM data are expected as well."

sparser
"During telephone interviews, the following tests were conducted: the Patient-Reported Outcomes Measurement Information System (PROMIS) 13 Cognitive Function Abilities 4a, Short Blessed Test (score 0-4 = normal cognition, score 5-9 = questionable impairment, score ≥10 = impairment consistent with dementia), 14 Family Confusion Assessment Method (FAM-CAM) for delirium, 15 and the Patient Health Questionnaire-9 (scores ≥10 were considered positive screens for depression)."

sparser
"This study found an incidence of delirium to be 1.4% (2 of 141 patients) three to 5 days after surgery using the FAM-CAM tool."

sparser
"The FAM-CAM xref is an informant-based delirium assessment that may help EDs overcome the barriers to delirium screening by sharing the workload of screening with a caregiver, when available."

sparser
"The FAM-CAM had a specificity of 83% and NPV of 83%."

sparser
"Again, the majority of false negatives in patients with dementia (n=6 out of 9, 67%) were due to the caregiver not identifying inattention on the FAM-CAM."
GO affects CALM1
| 48
CALM1 binds GO. 10 / 48
| 48

sparser
"Finally, the Gene Ontology Causal Activity Models (GO-CAM, [44]) consists of pathways annotated (manually or computationally) with the Gene Ontology (GO) terminology [45] (i.e. with GO terms describing biological processes, molecular functions and cellular components)."

sparser
"GO-CAM is robust in terms of computational aspects: OWL is a powerful representation that structures knowledge in a way that allows for reasoning and offers the potential for real-time consistency checking during a curation process."

sparser
"GO-CAM is based on the GO terminology and uses the Relation Ontology (RO) terms for the annotation of causal interactions [95]."

sparser
"GO-CAM models center on molecular functions that are part of a biological process, which in turn are part of regulatory or signaling networks."

sparser
"The new GO-CAM curation encourages the annotation of biological pathways, with relations between GO terms added for each step in the pathway (see xref )."

sparser
"For example, the schema includes constraints that define allowable evidence and provenance structures for each assertion within a GO-CAM."

sparser
"Causality between entities in a GO-CAM model is defined via building blocks of the form: ‘a molecular function, enabled by a gene product, regulates a molecular function, enabled by the same or another gene product’."

sparser
"The GO-CAM documentation, data and download are directly accessible through."

sparser
"Current formats of causal statements range from the simplest, with only two entities and the causal relationship [e.g. the Simple Interaction Format (SIF) with ‘A activates B’ or ‘A -> B’], to more complex statements including contextual description [e.g. BEL (Biological Expression Language) ( xref ; xref ), GO-CAM ( xref ) and PSI-MITAB2.8 ( xref )]."

sparser
"We focus on our progress on the curation and public release of GO-CAM models, the continuous collaborative work to refine the GO ontology, the review and improvement of the quality of our annotations, and the expansion of the usability of GO through a redesigned website, documentation, data access, visualization widget and 15 years of historical archives of the GO knowledgebase."
CALM1 is modified
| 31 4
CALM1 is phosphorylated.
| 11 4
CALM1 is phosphorylated. 10 / 15
| 11 4

rlimsp
"Thus, our results raise the possibility that the calmodulin-binding domain is directly involved in the membrane association of eNOS and that phosphorylation of the domain and Ca(2+)-calmodulin may regulate the interaction."

sparser
"After incubation of cultured hepatocytes with [32P]Pi, phosphorylated cell-CAM 105 could be isolated."

sparser
"Furthermore, CSC (25 microgram/ml) both increases the rate of transendothelial migration of vitamin D3-differentiated monocyte-like cells across the HUVEC monolayer by 200% and causes an approximately 10-fold increases in the phosphorylation of platelet endothelial CAM (PECAM-1), an adhesion molecule located at intercellular junctions and involved in endothelial cell-cell adhesion."

sparser
"Cam-PK Phosphorylation of phospholamban following chymotryptic digestion of cardiac SR There are at least two explanations that could account for the decreased level of Cam-PK-catalyzed phosphorylat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

rlimsp
"The presence of added Ca2+ led to a small potentiation of poly-L-lysine-dependent calmodulin phosphorylation at low concentrations, with inhibition occurring at higher concentrations where Ca2+ was shown to block calmodulin precipitation by poly-L-lysine."

sparser
"Interestingly, we observed that phosphorylation of CaM1 only has a modest impact on its affinity for calcium."

sparser
"328 Volume 155, number 2 FEBS LETTERS May 1983 Table 1 Phospholamban phosphorylation and oxalate-supported Ca^-uptake in mixed membrane preparations of embryonic, developing and adult [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"All reactions were monitored by thin layer chromatography (TLC) carried out on either Merck silica gel plates (0.25 mm thick, 60F254) or Millipore Silica gel aluminum sheets (60F254) and visualized by using UV (254 nm) or dyes such as KMnO 4 , p -anisaldehyde, and CAM (Hannesian’s Stain)."

sparser
"All reactions were monitored by thin layer chromatography (TLC) carried out on Merck silica gel plates (0.25 mm thick, 60F254), visualized by using UV (254 nm) or dyes such as KMnO 4 , p -Anisaldehyde and CAM."

sparser
"In no case, was affinity labeling more sensitive to proteinase digestion than was the endogenous Cam-PK-catalyzed phosphorylation of phospholamban; i.e., the Cam-PK phosphorylation of phospholamban wa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
CALM1 is glycosylated.
| 13
CALM1 is glycosylated. 10 / 13
| 13

sparser
"It remains to be shown whether glycosylation of soluble C-CAM corresponds to glycosylation of membrane bound C-CAM."

sparser
"Thus, these findings suggest that differential glycosylation of a widely expressed neural CAM can functionally regulate neuronal outgrowth and synapse formation of distinct neuronal subpopulations."

sparser
"Additionally, the glycosylation of HSLFHPEDTGQVFQVSHSFPHPLYN102M CAM SLLK peptide was identified, where M CAM represents carbamidomethylaion of methionine residue."

sparser
"The absence of N-acetyl-galacto-samine, as shown by monosaccharide composition analysis, suggests that C-CAM is exclusively N-glycosylated."

sparser
"The presence of type I and type II chains in the antennae of these glycans results in heterogeneous glycosylation of C-CAM."

sparser
"This phenomenon is known as "oversialylation." In a former study Bierhuizen et al. (1989) characterized the glycosylation of C-CAM from rat liver using lectin-agarose affinity chromatography of desialylated, 14 C-labeled glycopeptides."

sparser
"In addition, studies in our laboratories have been performed and are still in progress, mainly aimed to elucidate the expression and significance of the CAM glycosylation patterns, as well as to identify and characterize membrane molecular components implicated in the ion transport processes which occur in the chorionic epithelium [ xref – xref ]."

sparser
"NCAM120 is a prominent example of a glycosylated GPI-anchored IgSF CAM ( xref ), because similarly to transmembrane NCAM isoforms it can carry polysialic acid (PSA) ( xref )."

sparser
"Based on these results, it was concluded that there were significant differences in the glycosylation of ARH and THC cell-CAM 105."

sparser
"Further advances in production of metal coatings with finer granularity, together with improvements in imaging (tilting and angle of stereo images), may provide better definition of the topography associated with glycosylation and formation of multimeric CAM complexes. (J Histochem Cytochem 49:809-819, 2001)"
CALM1 is acetylated.
| 3
CALM1 is acetylated. 3 / 3
| 3

sparser
"DoerflerlFEBS Letters 344 (1994) 251 254 [12,19] and expressed as percent conversion of chloramphenicol (CAM) to acetylated CAM forms during a 1 h incubation."

sparser
"All CAM acetyltransferases share similar molecular strategies in acetylating CAM."

sparser
"High-level resistance to CAM commonly is mediated by chloramphenicol acetyltransferase (CAT) which catalyzes the acetylation of CAM and renders the drug inactive."
CALM1 is methylated.
| 2
CALM1 is methylated. 2 / 2
| 2

sparser
"Methylation of CAM may be correlated with risk and prognosis of ovarian cancer."

sparser
"The recently completed genome of pineapple has and will continue to facilitate many areas of research in this species, and the present work focuses on the regulatory impact of DNA methylation on CAM pathway-related genes using temporal and spatial methylome and transcriptome analysis."
CALM1 is hydroxylated.
| 2
CALM1 is hydroxylated. 2 / 2
| 2

sparser
"CAM putida Pseudomonas P-450LIN linalool hydroxylation - n."

sparser
"Among cytochrome P450 enzymes the camphor hydroxylating system P450 CAM is the most thoroughly investigated one and details on its active site and inhibitors are known [19,20] ."
CEACAM5 affects CALM1
| 33
| 33

sparser
"As majority of the patients had normal LDH levels, CEA-CAM1 value facilitates a more precise prognostic prediction [60, 73] ."

sparser
"One representative chromatogram is shown in Figure 2A . Three amino acids were identified in each cycle of automated Edman degradation of peak 9 on Figure 2A . These data could be assembled to three peptide sequences of VFYWYK, ETIYSN, and AIYWYR in CEA-CAM10."

sparser
"Interestingly, CEA-CAM 5 is temporarily produced during fetal development until birth."

sparser
"We then removed the following features that were flagged in >0.5% of cells in the CITE-seq dataset: CD269 (TNFRSF17), CD304 (NRP-1), CD66b (CEA-CAM8), CD80, and TCR Va24-Ja18."

sparser
"In addition, Silencing CEA-CAM 6 by RNAs decreased tumor proliferation by 68% in pancreatic cancer xenograft mice compared to control siRNAs (f."

sparser
"In vitro and in vivo studies on melanoma xenografts show that antibodies built to target the extracellular portion of CEACAM1 and to block the N-domain of CEACAM1 (MRG1, a murine IgG1 monoclonal antibody against human CEA-CAM1) did not influence the proliferation rate but facilitate melanoma cell elimination by T cells and have no agonistic effect."

sparser
"These could not be explained by higher sensibility of the IL-33 KO mouse strain as the expression of the basic receptors described to be involved in the infectivity such as CEA-CAM [27] , TLR2 [22, 28] , and TLR3 [29] receptors were expressed at a comparable level in WT and IL-33 KO mice."

sparser
"Pathogens thus exploit the normal physiological function of CEA-CAM1 which acts as an immune inhibitory receptor on leukocytes upon homotypic or heterotypic interactions for example with other CEACAM members [7, 12] ."

sparser
"Fimbrial proteins of several strains of Escherichia coli and Salmonella bind to D-mannosyl residues on CEA, NCA and human C-CAM [49, 50] ."

sparser
"Our scope, once again, is GPI anchored CEAs: CEA-CAM 6 and CEA-CAM 5, which is also known as CD66e ( xref )."
CALM1 affects NFATC2
33 |
CALM1 dephosphorylates NFATC2.
32 |
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S110. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S280. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S172. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S180, S268, S274, S53, S177, and S213 on S326. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S276. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S53, S177, and S213 on S274. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, and S213 on S177. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S326, S180, S268, S274, S53, S177, and S213 on S221. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S274, S53, S177, and S213 on S268. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S221, S326, S180, S268, S274, S53, S177, and S213 on S175. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S171. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S174. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S217. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, and S177 on S213. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S268, S274, S53, S177, and S213 on S180. 2 / 2
2 |

No evidence text available

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S268, S171, S56, S217, S243, S110, S53, S172, S99, S175, S236, S326, S180, S363, S274, S221, S177, and S213 on S280. 1 / 1
1 |

No evidence text available
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S268, S171, S217, S280, S243, S110, S53, S172, S99, S175, S236, S326, S180, S363, S274, S221, S177, and S213 on S56. 1 / 1
1 |

No evidence text available
CALM1 activates NFATC2.
1 |
CALM1 activates NFATC2. 1 / 1
1 |

No evidence text available
CALM1 affects CEACAM5
| 33
| 33

sparser
"As majority of the patients had normal LDH levels, CEA-CAM1 value facilitates a more precise prognostic prediction [60, 73] ."

sparser
"One representative chromatogram is shown in Figure 2A . Three amino acids were identified in each cycle of automated Edman degradation of peak 9 on Figure 2A . These data could be assembled to three peptide sequences of VFYWYK, ETIYSN, and AIYWYR in CEA-CAM10."

sparser
"Interestingly, CEA-CAM 5 is temporarily produced during fetal development until birth."

sparser
"We then removed the following features that were flagged in >0.5% of cells in the CITE-seq dataset: CD269 (TNFRSF17), CD304 (NRP-1), CD66b (CEA-CAM8), CD80, and TCR Va24-Ja18."

sparser
"In addition, Silencing CEA-CAM 6 by RNAs decreased tumor proliferation by 68% in pancreatic cancer xenograft mice compared to control siRNAs (f."

sparser
"In vitro and in vivo studies on melanoma xenografts show that antibodies built to target the extracellular portion of CEACAM1 and to block the N-domain of CEACAM1 (MRG1, a murine IgG1 monoclonal antibody against human CEA-CAM1) did not influence the proliferation rate but facilitate melanoma cell elimination by T cells and have no agonistic effect."

sparser
"These could not be explained by higher sensibility of the IL-33 KO mouse strain as the expression of the basic receptors described to be involved in the infectivity such as CEA-CAM [27] , TLR2 [22, 28] , and TLR3 [29] receptors were expressed at a comparable level in WT and IL-33 KO mice."

sparser
"Pathogens thus exploit the normal physiological function of CEA-CAM1 which acts as an immune inhibitory receptor on leukocytes upon homotypic or heterotypic interactions for example with other CEACAM members [7, 12] ."

sparser
"Fimbrial proteins of several strains of Escherichia coli and Salmonella bind to D-mannosyl residues on CEA, NCA and human C-CAM [49, 50] ."

sparser
"Our scope, once again, is GPI anchored CEAs: CEA-CAM 6 and CEA-CAM 5, which is also known as CD66e ( xref )."
EHD1 affects CALM1
| 27
| 27

sparser
"A large proportion of the LBP population—over 40%—used some form of CAM in the past year, with higher use reported among those with limiting back pain."

sparser
"Factors associated with CAM use in the past 12 months were different for men and women; income and obesity were associated with CAM use in the past 12 months among women and not among men."

sparser
"Among the participants, 15 (60%) had used some form of CAM in the past 12 months, while 10 (40%) had not."

sparser
"6.4% of Singaporeans used at least one form of CAM in the past 12 months for their mental illness."

sparser
"Among the US Navy and Marine Corps personnel who participated in this study, 37% reported using at least one form of CAM in the past year."

sparser
"Use is common and has significantly increased over the past decade, with close to 40 % in 2007 using some form of CAM in the past year [ xref – xref ]."

sparser
"35.1% of adults with cancer reported using some form of CAM in the past 12 months."

sparser
"Without including prayer, and regardless of health status, about two-thirds of our respondents had used some form of CAM in the past year."

sparser
"Here, the data indicated that, with regard to the presenting medical problem, the most common CAM used was herbs (7%) and spiritual healing (7%); chiropractic rated just 0.3%; however, when looking at who had used various forms of CAM in the past 12 months, 7% had seen a chiropractor, while herbs (24%) and massage therapy (17%) were most common."

sparser
"In our study, 49.4% of participants used some form of CAM in the past month, a rate which is significantly higher than the use of CAM by cancer patients in general, reported to be 27% [ xref ]; in turn, prevalence of CAM use by cancer patients across diverse cancers is only slightly higher than the use of CAM in the past year by the Danish population in general which was reported to be 26.3% (31.3% women; 21.1% men) in 2010 [ xref ]."
CALM1 affects calcium(2+)
2 | 17
2 | 8

reach
"Ca ^-dependent binding of nitrendipine to calmo- dulin."

reach
"As summarized in Table I, dogfish erythrocyte D245 and mammalian brain a-fodrin are similar in that they ex- hibit comparable electrophoretic mobili- ties, comparable calcium dependent cal- modulin bi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1."

reach
"We demonstrated that KIF1Bbeta promotes mitochondrial fission by promoting CN dependent dephosphorylation of DRP1 on Ser637.KIF1Bbeta binds to the Ca 2+ sensor and adaptor protein CALM2, a key regulat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"When calmo- dulin binds calcium, it adopts a folded configuration that can then bind to target proteins such as calmo- dulin dependent protein kinase."

"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+–CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the E–F hands in each domain and dramatically changes the two domains of CaM to produce more ‘open’ conformations"

reach
"The calcium binding activity of calmodulin, which TABLE I THE EFFECT OF EDTA ON BINDING OF CALCIUM TO CALMODULIN Bound calcium Addition (pmol) Calmodulin 140 Calmodulin + EDTA 15 - 26 EDTA 23 Note."

reach
"The free calcium concentration at which calmo-dulin binds calcium ions is strongly influencedby the ionic environment and by the presence of target proteins."

reach
"It is speculated that the extract could prevent calcium influx, inhibit the calcium-in- duced calcium release mechanism, prevent the release of calcium from the sarcoplasmic reticu- lure or prevent th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Sasaki, T., Naka, M., Nakamura, F. and Tanaka, T. (1992) Ruthenium red inhibits the binding of calcium to cal- modulin required for enzyme activation."
CALM1 activates calcium(2+).
| 5
| 5

reach
"To examine if CAM mediates the regulatory effects of calcium on phototransduction, we analyzed light responses of wild-type and cam cells in various extracellular calcium concentrations."

reach
"Meanwhile, calmo- dulin was reported to activate calcium uptake by cardiac SR vesicles [14]."

reach
"Cahalan and Hall [21] have elegantly demonstrated the regulation of MIP water permeability by Ca 2+, which is modulated by CAM."

reach
"Regulation of calcium transport in the CAM is not clearly understood; physical interaction of the CAM with the eggshell and/or shell membranes is needed to stimulate development of a functional calciu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Moreover, a Ca ^-ATPase stimulated by PICA and PKG and CAM dependent protein kinases has been described in a microsomal fraction from canine trachea!"
CALM1 inhibits calcium(2+).
| 4
| 4

reach
"As shown in Figure 6, the spontaneous Ca 2+ transients were inhibited by incorporation of GSH-CaM, but not by WT-CaM, while domain zipper, dantrolene had no notable anti-arrhythmogenic effect."

reach
"In this regard, the novel splice variant of CaM-2 decreased significantly the peak current density of recombinant Ca V 2.3 channels."

reach
"A second calmodulin mutant, cam2, also inhibits the Ca Z +-dependent K+ current [196]."

reach
"In another study [20], the CAM antagonists CGS 9343B and calmidazolium were both found to reversibly inhibit Ca 2+ oscillations in rat hepatocytes."
CALM1 affects EHD1
| 27
| 27

sparser
"A large proportion of the LBP population—over 40%—used some form of CAM in the past year, with higher use reported among those with limiting back pain."

sparser
"Factors associated with CAM use in the past 12 months were different for men and women; income and obesity were associated with CAM use in the past 12 months among women and not among men."

sparser
"Among the participants, 15 (60%) had used some form of CAM in the past 12 months, while 10 (40%) had not."

sparser
"6.4% of Singaporeans used at least one form of CAM in the past 12 months for their mental illness."

sparser
"Among the US Navy and Marine Corps personnel who participated in this study, 37% reported using at least one form of CAM in the past year."

sparser
"Use is common and has significantly increased over the past decade, with close to 40 % in 2007 using some form of CAM in the past year [ xref – xref ]."

sparser
"35.1% of adults with cancer reported using some form of CAM in the past 12 months."

sparser
"Without including prayer, and regardless of health status, about two-thirds of our respondents had used some form of CAM in the past year."

sparser
"Here, the data indicated that, with regard to the presenting medical problem, the most common CAM used was herbs (7%) and spiritual healing (7%); chiropractic rated just 0.3%; however, when looking at who had used various forms of CAM in the past 12 months, 7% had seen a chiropractor, while herbs (24%) and massage therapy (17%) were most common."

sparser
"In our study, 49.4% of participants used some form of CAM in the past month, a rate which is significantly higher than the use of CAM by cancer patients in general, reported to be 27% [ xref ]; in turn, prevalence of CAM use by cancer patients across diverse cancers is only slightly higher than the use of CAM in the past year by the Danish population in general which was reported to be 26.3% (31.3% women; 21.1% men) in 2010 [ xref ]."
Calcium(2+) affects CALM1
5 | 10
2 | 8

reach
"Ca ^-dependent binding of nitrendipine to calmo- dulin."

reach
"As summarized in Table I, dogfish erythrocyte D245 and mammalian brain a-fodrin are similar in that they ex- hibit comparable electrophoretic mobili- ties, comparable calcium dependent cal- modulin bi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1."

reach
"We demonstrated that KIF1Bbeta promotes mitochondrial fission by promoting CN dependent dephosphorylation of DRP1 on Ser637.KIF1Bbeta binds to the Ca 2+ sensor and adaptor protein CALM2, a key regulat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"When calmo- dulin binds calcium, it adopts a folded configuration that can then bind to target proteins such as calmo- dulin dependent protein kinase."

"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+–CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the E–F hands in each domain and dramatically changes the two domains of CaM to produce more ‘open’ conformations"

reach
"The calcium binding activity of calmodulin, which TABLE I THE EFFECT OF EDTA ON BINDING OF CALCIUM TO CALMODULIN Bound calcium Addition (pmol) Calmodulin 140 Calmodulin + EDTA 15 - 26 EDTA 23 Note."

reach
"The free calcium concentration at which calmo-dulin binds calcium ions is strongly influencedby the ionic environment and by the presence of target proteins."

reach
"It is speculated that the extract could prevent calcium influx, inhibit the calcium-in- duced calcium release mechanism, prevent the release of calcium from the sarcoplasmic reticu- lure or prevent th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Sasaki, T., Naka, M., Nakamura, F. and Tanaka, T. (1992) Ruthenium red inhibits the binding of calcium to cal- modulin required for enzyme activation."
Calcium(2+) activates CALM1.
3 | 2
3 | 2

"Except for nfat5, nfatc1c4 are activated upon a rise in intracellular ca2+, which stimulates the serine/threonine phosphatase activity of calcineurin the ca2+-calcineurin signal is the most important signal for regulating nfat activation, but the signal that leads to ca2+ influx during neural tube differentiation is still unclear."

"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+–CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the E–F hands in each domain and dramatically changes the two domains of CaM to produce more ‘open’ conformations"

reach
"This suggests that a calcium wave that reaches the soma and triggers a massive long lasting regenerative calcium release in the nucleus may activate CAM kinase IV and gene transcription in the absence[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Binding of four calcium ions induces a conformational change in calmod- ulin which can then activate a large number of proteins."

"Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1."
CALM1 affects HRAS
20 |
CALM1 is a GEF for HRAS. 10 / 20
20 |

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CEACAM7 affects CALM1
| 19
| 19

sparser
"Interestingly, CEA family members with N domains closely related to the corresponding CEA-CAM1 N domains, but with differently signalling cytoplasmic motifs, are found on granulocytes of humans (CEACAM3) and dogs (CEACAM28) [4, 17] ."

sparser
"BAC2Clone (214 kb) covered a large region proximal to human CEACAM1 on chromosome 19, and two other BAC clones (BAC3 and BAC5; 138, and 211 kb, respectively) covered shorter regions flanking the human CEA-CAM1 gene."

sparser
"Indeed, the 'L' isoform of CEACAM1 is a direct substrate of the IR, which phosphorylates CEA-CAM1 at Tyr-488, and this modification requires an intact Ser-503 residue in the cytoplasmic tail of CEA-CAM1 (reviewed in [31])."

sparser
"Furthermore, the expansion of PSG-like genes took place either close to CEACAM1, as in higher primates, or distal to the orthologous CEA-CAM gene cluster, as found in rodents ( Figure 3 )."

sparser
"In summary, abuse of the inhibitory receptor CEA-CAM1 by viral and bacterial pathogens to gain access to host cells as well as the paternal/maternal conflict in which PSGs possibly are involved have probably strongly contributed to the divergent evolution of the CEA family."

sparser
"While N exon nucleotide sequences of CEACAM16, CEACAM18, CEA-CAM19 and CEACAM20 from different species cluster together, all other CEACAM N domain exon sequences of a given species are most closely related with the corresponding CEACAM1 sequence of that species, indicating that these genes were generated independently by multiple rounds of duplication of an ancestral CEA-CAM1 gene possibly followed by gene conversion events ( Figure 1A )."

sparser
"It will be interesting to observe the further elucidation of CEA-CAM function and the phylogenic diversification of these glycoproteins in light of their exploitation as pathogen receptors in multiple mammalian species."

sparser
"A number of previous studies have implicated CEA-CAM1 in angiogenesis."

sparser
"Multispecies amino acid sequence comparison of the cytoplasmic regions of CEACAMs, therefore, allowed identification of sequence motifs which are indispensable for signalling of CEA-CAM receptors."

sparser
"The observed dN/dS ratio of about 0.1 for the CEACAM16 N2 domain exons indicates a high selective pressure on the conservation of this domain while the dN/dS ratio of~1 found for CEA-CAM1 N domain exons suggests no selection at all."
CALM1 affects NOS3
6 2 6 | 3 2
CALM1 binds NOS3.
1 6 | 2
1 6 | 2

sparser
"We did not observe any interaction between eNOS and CAV1, despite showing a specific and calcium-dependent interaction of eNOS and CALM1 using the same cf expression system."

No evidence text available

"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"

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sparser
"Additionally, CR can act on the genes of the upstream pathway, such as IL1B and TNF, which are proinflammatory mediators [ xref , xref ], while ATR can act on downstream genes, such as CALM1 and NOS3, which are associated with learning and memory and anti-inflammatory processes."
CALM1 phosphorylates NOS3.
6 |
CALM1 phosphorylates NOS3 phosphorylated on S1177 on S633. 6 / 6
6 |

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CALM1 activates NOS3.
1 | 3
CALM1 activates NOS3. 4 / 4
1 | 3

reach
"Fig. 7 E and F showed that KMUP-1 restored p-eNOS at day 28 and KMUP-1S increased p-eNOS at day-7 and at day-28, but Plus and CAM could not restore p-eNOS."

reach
"Plus and CAM group were less effective to restore eNOS."

reach
"VEGF stimulates NO production initially by increasing intracellular Ca 2 + levels and subsequent Ca 2 + -calmodulin dependent activation of eNOS, and later by increasing intracellular eNOS message and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
CALM1 affects CEACAM7
| 19
| 19

sparser
"Interestingly, CEA family members with N domains closely related to the corresponding CEA-CAM1 N domains, but with differently signalling cytoplasmic motifs, are found on granulocytes of humans (CEACAM3) and dogs (CEACAM28) [4, 17] ."

sparser
"BAC2Clone (214 kb) covered a large region proximal to human CEACAM1 on chromosome 19, and two other BAC clones (BAC3 and BAC5; 138, and 211 kb, respectively) covered shorter regions flanking the human CEA-CAM1 gene."

sparser
"Indeed, the 'L' isoform of CEACAM1 is a direct substrate of the IR, which phosphorylates CEA-CAM1 at Tyr-488, and this modification requires an intact Ser-503 residue in the cytoplasmic tail of CEA-CAM1 (reviewed in [31])."

sparser
"Furthermore, the expansion of PSG-like genes took place either close to CEACAM1, as in higher primates, or distal to the orthologous CEA-CAM gene cluster, as found in rodents ( Figure 3 )."

sparser
"In summary, abuse of the inhibitory receptor CEA-CAM1 by viral and bacterial pathogens to gain access to host cells as well as the paternal/maternal conflict in which PSGs possibly are involved have probably strongly contributed to the divergent evolution of the CEA family."

sparser
"While N exon nucleotide sequences of CEACAM16, CEACAM18, CEA-CAM19 and CEACAM20 from different species cluster together, all other CEACAM N domain exon sequences of a given species are most closely related with the corresponding CEACAM1 sequence of that species, indicating that these genes were generated independently by multiple rounds of duplication of an ancestral CEA-CAM1 gene possibly followed by gene conversion events ( Figure 1A )."

sparser
"It will be interesting to observe the further elucidation of CEA-CAM function and the phylogenic diversification of these glycoproteins in light of their exploitation as pathogen receptors in multiple mammalian species."

sparser
"A number of previous studies have implicated CEA-CAM1 in angiogenesis."

sparser
"Multispecies amino acid sequence comparison of the cytoplasmic regions of CEACAMs, therefore, allowed identification of sequence motifs which are indispensable for signalling of CEA-CAM receptors."

sparser
"The observed dN/dS ratio of about 0.1 for the CEACAM16 N2 domain exons indicates a high selective pressure on the conservation of this domain while the dN/dS ratio of~1 found for CEA-CAM1 N domain exons suggests no selection at all."
CALM1 affects B3LYP
| 17
CALM1 binds B3LYP. 10 / 17
| 17

sparser
"The success of CAM-B3LYP (and other range-separated functionals) is due to the fact that it includes a long-range correction of the exchange potential, which incorporates an increasing fraction of Hartree–Fock (HF) exchange as the interelectronic separation increases."
| PMC

sparser
"CAM-B3LYP strongly disfavors Baird aromaticity, yet based on this feature, one may also single out which macrocycles with high certainty are Baird-aromatic in reality."

sparser
"Range-separated hybrid functionals show significantly poorer performance compared to the meta -GGA hybrids, except for CAM-B3LYP-D3 (RMSD = 1.8 kcal mol –1 ), as pointed out in previous benchmark studies on expanded porphyrins. xref , xref We recently proved that M06-2X and CAM-B3LYP exhibit very similar degrees of π-electron delocalization in expanded porphyrins. xref Disappointingly, the promising range-separated hybrid ωB97M-V with nonlocal correlation, xref designed using a combinatorial approach and containing only 12 parameters, clearly underperforms the older ωB97XD for topology interconversions in expanded porphyrins."

sparser
"Among the plethora of functionals, the most often used to simulate the spectra of porphyrins are: B3LYP, CAM-B3LYP, and PBE0 [ xref , xref , xref , xref , xref , xref ]."
| PMC

sparser
"Based on numerous reports, it is usually advised to use CAM-B3LYP to predict adsorption spectra [ xref ]; see xref ."
| PMC

sparser
"In the singlet excited states Kim, Nakano, Yamago, and co-workers recently revealed rapid interconversion between self-trapped exciton and delocalized states, xref yet it has earlier been found through time-dependent CAM-B3LYP calculations that the S 1 state of [ n ]CPP ’s is more delocalized than the T 1 state. xref Similar observations in the T 1 state of various [ n ]CPP ’s could give experimental support as to which functional gives the right description: UB3LYP or UCAM-B3LYP?"

sparser
"xref shows that B3LYP, BHandHLYP, LC–wPBE, CAMB3LYP, wB97XD, and HF calculations give positive values for the complexation energy of the H 2 @C 50 complex, suggesting that this complex is thermodynamically unstable, regardless of the basis set used, 6-31G(d,p) or 6-311G(d,p)."

sparser
"In contrast, the CAM-B3LYP method exhibited slight overestimates on the excitation energies of T-705/BC23, T-705/B 12 N 12, and T-705/CB 11 N 12 complexes and underestimates at T-705/C 24 as compared to the UB3LYP method in gas and aqueous phases, xref , xref ."

sparser
"They demonstrated that the overestimation by 0.5 eV (in respect to the experimental data) of the transition energy for the relevant TPA state in [5,15-bis(3,5-bitert-butylphenyl)-10,20-bis(trihexylsilylethynyl)porphyrinato]zinc by B3LYP led to a 5-fold overprediction of the TPA cross-section for this molecule, whereas for 5,5′-(ethyne)bis[[10,20-bis(3,5-bitert- butylphenyl)-porphyrinato]zinc], underestimation of the transition energy by 0.5 eV with CAM-B3LYP and by 0.8 eV with B3LYP lead to underestimations of the TPA cross-section by factors of 2 and 4, respectively [ xref ]."
| PMC

sparser
"Just as in the case of B3LYP, the original CAM-B3LYP functional closely reproduces the coupled cluster reference values."
EP affects CALM1
| 16
CALM1 binds EP. 10 / 16
| 16

sparser
"4P–R) and collagen III positive and were SP-A, cytokeratin, EP-CAM, CD-45, CD-68 and CD-31 negative (data not shown), indicating that these infected cells are fibroblasts."

sparser
"Using a panel of monoclonal antibodies to keratinocyte differentiation and proliferation markers, we investigated the association of EP-CAM expression with differentiation-related and/or neoplastic changes in cervical epithelium."

sparser
"Finally, levels of epithelial cell adhesion molecule (EpCAM) and E‐selectin (SELE) found exclusively in epithelial and endothelial cells, respectively, were significantly higher in SEVs from patients with severe disease, albeit a less than 1.5‐fold increase compared to the uninfected controls."

sparser
"The small, cuboidal cells stained positive for SP-A, cytokeratin, EP-CAM, and a type II cell-specific antibody obtained from Dr."

sparser
"CD9, CD63, Alix, and EP-CAM can be enriched by antibody-coated magnetic beads."
| PMC

sparser
"In addition, CD9, CD63, Alix, and EP-CAM can be used for the isolation of exosomes."
| PMC

sparser
"To employ the hybrid plan, magnetite nanoparticles were bound to MCF-7 cells through the specific EP-CAM antibodies."

sparser
"EpCAM, as a downstream target gene of Wnt/β‐catenin signal, was positively expressed in non‐responders, which means EpCAM could be a biomarker for IFNAR2‐positive patients resistant to IFN/5‐Fu. xref "

sparser
"TNFR2 ligands were mainly on CD45 − EP-CAM + lung epithelial cells at steady-state ( xref )."

sparser
"The first bi-specific antibody to gain regulatory approval was Catumaxomab, which targeted CD3 on T cells and EP-CAM on tumor cells and was approved in 2009 by the European Union for the treatment of malignant ascites in patients with EpCAM-positive disease [115]."
EGFR affects CALM1
4 4 5 1 | 1
EGFR phosphorylates CALM1.
2 4 1 |
EGFR phosphorylates CALM1 on Y100. 7 / 7
2 4 1 |

No evidence text available

No evidence text available

"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."

No evidence text available

No evidence text available

No evidence text available

"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
EGFR binds CALM1.
4 1 | 1
4 1 | 1

No evidence text available

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No evidence text available

sparser
"Over-expressed CALM1 and EGFR were significantly associated with clinical stage, T classification and poor overall prognosis, respectively."

No evidence text available
EGFR inhibits CALM1.
2 |
EGFR inhibits CALM1. 2 / 2
2 |

"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."

"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
| 1 14

eidos
"CaM inhibitors ( CaMi ) and several kinases facilitate Ser-181 phosphorylation , thus promoting apoptosis ."

reach
"Identification of cells undergoing apoptosis in human PBMNC treated with CAM."

reach
"PtdEtn formation through PtdSer decarboxylation showed little change in apoptotic cells induced by UV irradiation or TNF-alpha and CHX similar to the CAM induced apoptosis, but [3 H] serine derived Pt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Our data also showed that caspase-1 was cleaved to its active 20 kDa form during CAM mediated apoptosis in U937 cells.To assess PtdSer biosynthesis in U937 cells during CAM induced apoptosis, cells we[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"The mechanisms by which CAM induces apoptosis and exerts its well known anti-cancer effects in tumour cells are not fully elucidated."

reach
"After induction of apoptosis by CAM also sequential time dependent increase of the 2E12 reactivity in all cell lines was detected."

reach
"For most experiments, camptothecin (CAM; Calbiochem) was administered at various concentrations to induce apoptosis with or without co-incubation or pre-incubation for 60 min with caspase inhibitor, c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"On the basis of this, it might be hypothesised that 1alpha,25 (OH) 2 D 3 suppresses CAM induced apoptosis by inhibiting cell proliferation, which then reduces the number of the dividing cells and thus[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Treatment with CAM for 5 h resulted in an 8-fold increase of newly radiolabelled PtdSer in the medium.We also examined the synthesis of other phospholipids during CAM induced apoptosis."

reach
"Furthermore, knockdown of CNA and CALM2 impairs apoptosis of primary sympathetic neurons following neurotrophin deprivation to the same extent as loss of DRP1 expression."
| 10 5
CALM1 activates angiogenesis.
| 8
| 8

reach
"The CAM assay supports the observation that TNFalpha induces neovascularization as reported before [38] and the active principles of Triphala, CA, CI, GA as well as the AlE inhibit angiogenesis induce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Angiogenesis Inhibition Data were obtained by the chorioallantoic membrane (CAM) test, an accepted in vivo angiogenesis assay [12, 13] that observes the inhibition of the initial embryonic vas- culari[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"The CAM assay supports the observation that TNFalpha induces neovascularization as reported before [38] and the active principles of Triphala, CA, CI, GA as well as the AlE inhibit angiogenesis induce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"The anti-angiogenic capacity of Serpin E1 is further supported by in vivo CAM data showing recombinant Serpin E1 preventing FGF2 induced angiogenesis."

reach
"Together, these findings suggest that integrin alphavbeta3 and MMP-2 associate on the same vascular sprouts during cytokine induced angiogenesis on the chick CAM or tumor induced angiogenesis within t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Fig. 2 B shows the effects of LY294002 on angiogenin induced angiogenesis in the chick embryo chorioallantoic membrane (CAM) in vivo."

reach
"In addition, antimetastatic activities for complexes 1 and 3 were observed by inhibition of cell migration by the wound healing assay and Boyden chamber assay, as well as inhibition of angiogenesis caused by MDA-MB-231 tumor cells in the CAM model."

reach
"The CAM (Chick Chorioallantoic Membrane) model allows the assessment of the degree of angiogenesis, as well as the quality of the newly formed vessels, when intervening vascular endothelial growth factors (VEGF) or conversely, factors that inhibit the development of new blood vessels, such as antiangiogenic drugs."
CALM1 inhibits angiogenesis.
| 2 5
| 2 5

reach
"We have found that CAM inhibits tumor angiogenesis, growth and metastasis of mouse B16 melanoma cells (Yatsunami, unpublished data)."

sparser
"Some, including our group, have reported that CAM inhibits neovascularization [ xref , xref , xref , xref ]."

reach
"We found that CAM and RXM inhibited angiogenesis induced by human lung cancer cells and mouse melanoma cells in a mouse dorsal air sac model [12,13]."

sparser
"These data indicate that inhibition of in vivo angiogenesis by CAM administered systematically may not be attributable to its effects on the implanted lung cancer cells, but rather to its effects on e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"We found that CAM and RXM inhibited angiogenesis induced by human lung cancer cells and mouse melanoma cells in a mouse dorsal air sac model [12,13] ."

sparser
"We have found that CAM inhibits tumor angiogenesis, growth and metastasis of mouse B16 melanoma cells (Yatsunami, unpublished data)."

sparser
"In addition to a direct effect on tumour cells, there is evidence that CAM can inhibit tumour-induced angiogenesis in mice [ xref ]."
| 13 1
CALM1 activates cell adhesion.
| 12
| 12

reach
"These observations raise the question as to what kind of agents could be utilized in an attempt to block migration of leukemic blasts in a therapeutic manner during induction therapy, and the candidat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Identifying the mechanisms by which CAMS, individually and in combination, initiate cellular interactions that alter tissue morphology [5] is a major challenge, as are the delineations of the signal p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"In this way, a cell is able to control CAM mediated adhesion in response to external stimuli (see also Update)."

reach
"If on the other hand a particular CAM mediates cell to cell adhesion and cells aggregate, they may become more mobile and protected from cytotoxicity."

reach
"The most provocative, however, are those that indicate that CAM mediated adhesion may lead to changes in gene expression and those that suggest that the expression of CAM genes may be regulated by the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"We found, as has also been described by others [21,22], that C- CAM 1 could mediate adhesion in vitro."

reach
"Nevertheless, it is clear that CAM mediated adhesion can have a significant effect on cell behavior."

reach
"The use of transfection to express CAMS in cells that normally do not express them also indicated that CAMS can influence a variety of cell parameters and provided some hint that CAM mediated adhesion[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Integrins are a basal and principal CAM that mediate cell adhesion to make solid tumor cells grow in three-dimensional architectures, and integrins are widely expressed in almost all cancer cells orig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"However, the application of anti-CAM Fab to retinal cells cultured through to neurite formation [36], to the outgrowth ofneurites from spinal ganglion cultures [38] and to isolated embryonic retina in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
CALM1 inhibits cell adhesion.
| 1 1
| 1 1

sparser
"Adhesion also was dependent on expression of CAM on the cell surface, since monoclonal antibodies to CAM inhibited adhesion of activated NK cells to varying degrees (from 50 to 80%)."

reach
"Second, EETs act as autocrine hormones to inhibit both IKK activity and cytokine induced CAM expression, which reduces the adhesion of inflammatory cells."
CALM1 affects PDE
| 14
CALM1 inhibits PDE.
| 7