IndraLab

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Curcumin inhibits CTSB. 2 / 3
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"Recent reports indicate that curcumin inhibits mammalian CTSB and CTSH with IC 50 in the nanomolar range under in vitro conditions."
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"First, mTOR suppression is required for Curcumin induced lysosomal activation, based on two important findings : (i) Curcumin treatment inhibits the Akt-mTOR pathway, which is consistent with the previous reports; [XREF_BIBR, XREF_BIBR] (ii) Curcumin fails to block mTOR activity and increase lysosomal acidification and Cathepsin B activity in Tsc2 -/- MEFs."
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