IndraLab

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"The observed inhibition of cathepsin L activation and LMP by DHA is consistent with our previous observation that this Omega-3 fatty acid inhibits cathepsin L activation and LMP in nerve growth factor differentiated PC12 cells during palmitic acid induced lipotoxicity, a process that occurs via both caspase dependent and -independent cell death [XREF_BIBR, XREF_BIBR]."
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"On the other hand, DHA effectively reduced TNF-α-caused necroptosis and autophagy by attenuating ROS production, ceramide production, lysosomal impairment, and cathepsin L activation in the L929 murine fibrosarcoma cell line [17]."
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"Increased cathepsin L expression and processing was not observed in cells preincubated with DHA in the presence or absence of TNF-alpha (XREF_FIG), consistent with the observation that DHA attenuated TNF-alpha-induced lysosomal dysfunction and cathepsin L activation."
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