IndraLab

Statements

Hydroxychloroquine inhibits viral entry. 15 / 15
| 15
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"Hydroxychloroquine impedes lysosomal acidification and autophagy , preventing in-vitro viral entry [ 106,116 ] ."
33642821
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"By contrast , hydroxychloroquine , which inhibits viral entry by increasing endosomal pH and affecting terminal glycosylation of the ACE2 receptor ( 19 ) , is predicted by the model to be less likely to be effective since drugs that act on viral entry would require exceptionally high suppression to achieve appreciable effects on viral production ."
| DOI
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"That CQ and HCQ can reduce viral entry , trafficking , and budding in vitro constitutes evidence of translational potential relies on the underlying assumption that symptom severity is a function of viral replication ."
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"79 Hydroxychloroquine , blocks viral entry by inhibiting glycosylation of host receptors and endosomal acidification and demonstrates in vitro activity against SARS-CoV-2 ."
| PMC
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"CQ and HCQ inhibit viral entry by impairing terminal glycosylation of ACE2 , which may reduce enzyme activity , elevating Ang II concentration and favoring the pressor axis ."
32686260
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"Furthermore , it has been described that hydroxychloroquine efficiently blocked viral entry and reduced SARS-CoV-2 genomes in Vero-E6 cells [ 20 ] , [ 21 ] ."
| PMC
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"The mechanism of action of how CQ and HCQ block viral entry and progression is still not completely understood , with several mechanisms being proposed : blocking of endosomal acidification , interference with glycosylation of ACE2 or viral proteins , direct binding to ACE2 or viral proteins , interference with viral endocytosis , sequestering of metals , and exertion of immunomodulatory effects ."
33693723
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"Hydroxychloroquine , an anti-malarial drug , facilitates endosomal acidification and blocks viral entry and fusion by inhibiting glycosylation of the host cellular receptors that bind with the viral proteins ( Sanders et al ., 2020 ) ."
32552595
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"Chloroquine , hydroxychloroquine , and arbidol were suggested to inhibit viral entry , whereas remdesivir was suggested to inhibit viral replication ."
| PMC
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"Given that HCQ and ivermectin inhibit the viral entry and reduce the viral RNA respectively , the antiviral activity can be reinforced ( Patr i , & Fabbrocini , 2020 ) ."
32837984
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"The synergistic effect can be produced by using both drugs as Hydroxychloroquine inhibits viral entry & fusion while Nitazoxanide up regulates innate immune response to prevent on-going viral replication ."
32305589
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"Chloroquine , hydroxychloroquine and azithromycin may elevate endosomal pH and hinder viral entry and RNA release process ."
33762954
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"It is suggested that hydroxychloroquine inhibits viral entry , and the mechanism of action against SARS-CoV-2 and other similar viruses is two-fold : first , it increases the pH in endosomes and inhibits viruses from utilizing their activity for cell fusion and entry ; second , it inhibits the glycosylation of angiotensin converting enzyme 2 ( ACE2 ) , which is the receptor targeted by some viruses , including SARS-CoV-2 , for cell entry [ 38 ] ."
33499310
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"Current knowledge suggests that since HCQ blocks viral entry , its site of action would be extracellular lung tissue and intracellularly in type 1 pneumocytes ."
33390974
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"HCQ acts on the ACE2 receptor and prevents viral entry by inhibiting its interaction with spike glycoprotein-ganglioside ."
| PMC