IndraLab

Statements



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"Of note, autophagy in the in vivo scenario will be strengthened by other evidence like HCQ mediated LC3 accumulation XREF_BIBR, XREF_BIBR and immunohistochemistry analysis of autophagy associated proteins 26."

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"Hydroxychloroquine (HXQ) was used as a positive control to cause LC3 puncta."

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"Unsurprisingly, HCQ markedly increased the accumulation of P62 and LC3‐II proteins."

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"Monensin, nigericin, chloroquine, hydroxychloroquine, NH 4 Cl, procainamide, lidocaine hydrochloride and betahistine all induced LC3 lipidation in wild-type cells (XREF_FIG and Fig.S2A)."

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"Lipidated LC3 reflecting autophagy inhibition is decreased in KO PPT1 cells treated with either HCQ, Lys05 or DC661, respectively, compared to WT PPT1 cells."