IndraLab

Statements

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"These clinical observations are consistent with the translational research data showing a reduced type I interferon signature in monocytes of primary APS patients treated with hydroxychloroquine [70]."
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"While patients with APS are often treated with hydroxychloroquine (HCQ), its effect on trophoblast function is poorly understood."
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"Comparing APs, HCQ prolongs APD during phase-III repolarization, resulting in a higher triangulation ratio than AZM alone or AZM combined with HCQ."
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"In APS, HCQ can modulate pH by similar pathways as described above [71, 72]."
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"Recently, Albert et al. [69] showed that HCQ reversed the aPL-inhibition of trophoblast IL-6 secretion and partially limited aPL-inhibition of cell migration, suggesting that some form of combination [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HCQ increased the percentage of APS passing through the cells from 40.5% to 90.3%, as compared to the control group (Figure 3A)."
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"This effect is restored by HCQ, suggesting its therapeutic interest in APS pregnancies."
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