IndraLab

Statements

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"Since, there was still a reduction in IL-1beta production, it supports the notion that the action of HCQ to block IL-1beta is not at NF-kappaB but rather by blocking LMP."
31556748
eidos
"HCQ also caused significant reduction in the production of IL-1beta in BMDM after cSiO2 exposure ( Fig. 1C ) ."
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"Therefore, it could be suggested that HCQ blocked IL-1beta release by acting on the NF-kappaB pathway as previously proposed."
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"We also detected the cytokine production in the supernatants of purified DCs stimulated with RA patient serum with or without HCQ, and we found that HCQ inhibited the secretion of IFN-alpha, but not TNF-alpha and IL-1beta (XREF_FIG D)."
33049581
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"In vitro, HCQ inhibited IL-1beta and caspase 1 activation induced by ATP in a dose dependent manner."
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"In high-fat diet-induced obese mice, HCQ decreased the hepatic levels of macrophage-specific genes [cluster of differentiation 68 (CD68) and arginase 1 (Arg1)] and pro-inflammatory genes (IL-1β, TNF-α and MCP-1)."
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"However, IL-1beta secretion was not inhibited by HCQ."
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"HCQ blocks IL-1beta production in ex vivo culture Since HCQ was effective in blocking silica-induced IL-1beta release from BMDM and the data showed that HCQ was taken up by lysosomes in AM , the AM from the mice were evaluated ex vivo ."
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"Hydroxychloroquine inhibits IL-1beta production from amyloid-stimulated human neutrophils."
31775905
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"CQ and HCQ may inhibit the release of IL-6, IL-1B, and TNF-a and so cause a decrease in hepcidin and inhibit viral replication [32]."
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"We also detected the cytokine production in the supernatants of purified DCs stimulated with RA patient serum with or without HCQ, and we found that HCQ inhibited the secretion of IFN-alpha, but not TNF-alpha and IL-1beta."
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"Again, HCQ could not inhibit IL-1beta nor caspase 1 activation triggered by nigericin."
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"Fujita et al. demonstrated that hydroxychloroquine significantly inhibited IL-1b production in activated human neutrophils in vitro (Fujita et al., 2019)."
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"HCQ was able to block the production of IL-1beta and the release of NAG into the cytosol in cSiO 2 -exposed BMDM indicating that LMP was being prevented."
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"In addition, HCQ decreased the inflammatory cytokine IL-1β and the inflammatory mediator iNOS."
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"Hydroxychloroquine inhibits IL-1beta production from amyloid stimulated human neutrophils."
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"Hydroxychloroquine inhibits IL-6, IL1-beta and TNF-alfa release, and it showed also anti-thrombotic properties interfering with platelet aggregation and blood clotting proteins."
| PMC
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"These findings suggest that hydroxychloroquine affects the activation process of NLRP3, and reduces the production of IL-1beta in human neutrophils as the innate immune cells."
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"The use of HCQ and CQ has been reported to reduce the overproduction of IL-1B, IL-6, and Granulocyte-colony stimulating factor (GM-CSF)."
32884603
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"Hydroxychloroquine inhibits IL-6 , IL1-beta and TNF-alfa release ( Quiros Roldan et al ., 2020 ) , and it showed also anti-thrombotic properties interfering with platelet aggregation and blood clotting proteins ( Quiros Roldan et al ., 2020 ) ."
| PMC
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"Western blot studies showed that HCQ treatment impaired the secretion of mature IL-1beta but did not modify the levels of pro-IL-1beta in the cell lysate when stimulated with ATP."
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