IndraLab

Statements

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"HCQ inhibits SiHa cell proliferation by inducing apoptosis."
24944668
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"Here we demonstrate that in human T cells there is a basal level of autophagy and that the inhibition of autophagy by hydroxychloroquine induces apoptosis."
23541328
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"Previous studies by two groups of researchers demonstrated that CQ and HCQ suppressed apoptosis of pancreatic β-cells in diabetic condition but stimulated apoptosis of pulmonary artery smooth muscle cells in hypertensive condition."
34104100
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"Furthermore, we found that autophagy suppression by hydroxychloroquine promotes apoptosis in a cancer cell model that had been treated with Src inhibitors."
34673141
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"Hydroxychloroquine Attenuates Acute Inflammation (LPS)-Induced Apoptosis via Inhibiting TRPV1 Channel/ROS Signaling Pathways in Human Monocytes."
34681066
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"In addition, HCQ inhibited growth of cholangiocarcinoma cell line xenograft tumors.Conclusion: HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition, which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment."
34568426
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"In mice with established SjD-like phenotype, HCQ treatment also significantly decreased apoptotic cell death and ameliorated salivary gland hypofunction."
36821638
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"Hydroxychloroquine sulphate inhibits in vitro apoptosis of circulating lymphocytes in patients with systemic lupus erythematosus."
11495297
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"Autophagy inhibition via siRNA targeting of AMPK or hydroxychloroquine, an autophagy inhibitor, was found to induce apoptosis in NS1643-treated cells."
| PMC
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"When cholangiocarcinoma cells underwent apoptosis (IC50 concentration), the fusion of autophagosomes and lysosomes was inhibited by HCQ, while autophagy proceeded smoothly upstream."
34568426
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"Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth by targeting basal autophagy and enhancing apoptosis."
28433067
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"To the best of our knowledge, the current study provides the first evidence that HCQ inhibits the autophagy of cervical cancer SiHa cells and then prevents their proliferation by promoting apoptosis."
24944668
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"In this study we have shown for the first time that HCQ treatment decreased apoptosis in HI newborn rat model in both hemispheres."
35292947
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"Taken together, these data show that inhibition of autophagy by HCQ triggers apoptosis and suppresses cell proliferation in RCC cell lines."
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