IndraLab

Statements

reach
"In mice with established SjD-like phenotype, HCQ treatment also significantly decreased apoptotic cell death and ameliorated salivary gland hypofunction."
36821638
reach
"Autophagy inhibition via siRNA targeting of AMPK or hydroxychloroquine, an autophagy inhibitor, was found to induce apoptosis in NS1643-treated cells."
| PMC
reach
"In this study, we demonstrated that HCQ decreased apoptotic cell death induced by LAMP3 overexpression in salivary gland epithelial cells."
36821638
reach
"Interestingly, our results indicated that HCQ paradoxically prevented apoptosis in LAMP3-overexpressing epithelial cells."
36821638
reach
"We found that 5 μg/mL of HCQ had little influence on neural cell apoptosis, but decreased the anti-P-induced cell apoptosis ( Fig. 4 C F)."
34229206
reach
"Previous studies by two groups of researchers demonstrated that CQ and HCQ suppressed apoptosis of pancreatic β-cells in diabetic condition but stimulated apoptosis of pulmonary artery smooth muscle cells in hypertensive condition."
34104100
reach
"The results of our study showed that HCQ could reduce cell apoptosis induced by anti-P antibodies in the hippocampal neurons of primary cultures extracted from mice, further supporting the neuroprotec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34229206
reach
"Here we demonstrate that in human T cells there is a basal level of autophagy and that the inhibition of autophagy by hydroxychloroquine induces apoptosis."
23541328
reach
"Hydroxychloroquine sulphate inhibits in vitro apoptosis of circulating lymphocytes in patients with systemic lupus erythematosus."
29716424
reach
"Hydroxychloroquine sulphate inhibits in vitro apoptosis of circulating lymphocytes in patients with systemic lupus erythematosus."
11495297
reach
"In this study we have shown for the first time that HCQ treatment decreased apoptosis in HI newborn rat model in both hemispheres."
35292947
reach
"In a recent study, HCC cells were treated with a combined treatment of HCQ and sorafenib, which reduced tumor growth, cellular proliferation, migration, and invasiveness by suppressing autophagy and regulating apoptosis, overcoming drug resistance."
38973850
reach
"Hydroxychloroquine inhibits the growth of lung cancer cells by inducing G1 cell cycle arrest and apoptosis."
39460964
reach
"CQ and HCQ inhibit osteoblastic activity by suppressing autophagy, inducing oxidative stress and promoting osteoblast apoptosis."
40243121
reach
"In addition, HCQ inhibited growth of cholangiocarcinoma cell line xenograft tumors.Conclusion: HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition, which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment."
34568426
reach
"HCQ inhibits SiHa cell proliferation by inducing apoptosis."
24944668
reach
"To the best of our knowledge, the current study provides the first evidence that HCQ inhibits the autophagy of cervical cancer SiHa cells and then prevents their proliferation by promoting apoptosis."
24944668
reach
"Taken together, these data show that inhibition of autophagy by HCQ triggers apoptosis and suppresses cell proliferation in RCC cell lines."
26134285
reach
"Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth by targeting basal autophagy and enhancing apoptosis."
28433067
reach
"Furthermore, we found that autophagy suppression by hydroxychloroquine promotes apoptosis in a cancer cell model that had been treated with Src inhibitors."
34673141
reach
"Finally, we asked whether the autophagy inhibitor HCQ would enhance the ability of Narc to inhibit proliferation and induce apoptosis ( Fig. 7 )."
29787814
reach
"When cholangiocarcinoma cells underwent apoptosis (IC50 concentration), the fusion of autophagosomes and lysosomes was inhibited by HCQ, while autophagy proceeded smoothly upstream."
34568426
reach
"Hydroxychloroquine Attenuates Acute Inflammation (LPS)-Induced Apoptosis via Inhibiting TRPV1 Channel/ROS Signaling Pathways in Human Monocytes."
34681066
reach
"Another study reported that combining 2-DG with autophagy inhibiting drug hydroxychloroquine enhances apoptosis in BC cells."
36768924
reach
"The addition of hydroxychloroquine, an autophagy inhibitor, reduced autophagy and increased apoptosis in DLBCL cells."
38393538