IndraLab

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"FKBP5: A549 VC v DHT p = 0.0250, DHT v ENZA p = 0.0493, DHT v DHT + ENZA p = 0.0285; H1944 VC v DHT p = 5.7 × 10 -6 , DHT v ENZA p = 7.1 × 10 -5 , DHT v DHT + ENZA p = 1.7 × 10 -5Enzalutamide downregulates Tmprss2 in mouse lung."
34210968
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"The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic, is a positive-sense single-stranded RNA coronavirus highly related to SARS-CoV, which caused the 2002/2003 SARS pandemic1,2."
34210968
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"Both RD162 and MDV3100 antagonized induction of PSA and TMPRSS2 by the synthetic androgen R1881 in parental LNCaP cells (XREF_SUPPLEMENTARY)."
19359544
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"by mining publicly available data on gene expression, identified that the estrogen-related compounds including genistein, androgen receptor antagonist enzalutamide and estradiol can down-regulate the TMPRSS2."
34527703
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"On the other hand , TMPRSS2 was induced significantly upon DHT exposure and was suppressed by enzalutamide or WBM ."
33791688
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"Consistently , enzalutamide significantly decreased TMPRSS2 expression and inhibited SARS-CoV-2 infection in human prostate cancer cells ( Fig. 2 ) ."
33558541
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"The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV- 2 in human lung cells.SARS-CoV-2 attacks various organs, most destructively the lung, and cellular entry requires two host cell surface proteins: ACE2 and TMPRSS2."
34210968
reach
"The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells."
34210968
eidos
"Distinct from results in LNCaP cells that DHT stimulated TMPRSS2 expression and enzalutamide reduced TMPRSS2 expression , respectively , no obvious changes in TMPRSS2 expression were observed in H2126 and H1437 cells with these two treatments ( Supplementary Fig. 5g ) ."
33558541
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"Notably , unlike in LNCaP cells , in which DHT stimulated and enzalutamide reduced TMPRSS2 expression , no obvious changes in mRNA expression of TMPRSS2 were observed in H2126 and H1437 cells treated with these two agents ( Supplementary Fig. 5c-f ) ."
33558541
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"Thus , an AR inhibitor , enzalutamide can reduce TMPRSS2 expression , subsequently resulting in the attenuated entry driven by SARS-CoV-2 ."
33558541
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"On the other hand , TMPRSS2 was induced signi cantly upon DHT exposure and was suppressed by enzalutamide or WBM ."
33791688
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"In line with this , enzalutamide ( an androgen receptor antagonist ) , estradiol , and the phytoestrogen genistein were recently reported to downregulate the expression of TMPRSS2 using RNA sequencing data derived from human prostate , breast , and endometrial cancer cell lines ."
33369210
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"The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells."
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