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Hydroxychloroquine increases the amount of SQSTM1. 6 / 8
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"Compared with SHK treated group, HCQ increased the expression of LC3B and p62 induced by SHK combination strategies, SHK + HCQ and HCQ followed by SHK, suggesting that a combination of SHK and HCQ cou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, HCQ slightly increased p62 expression compared to the control group."
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"In this study, we found that p62 levels increased on inhibition of autophagy by 3-methyladenine or HCQ, or on knockdown of ATG3 ( Fig. 2 )."
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"In our study, we found d -gal dramaticlly increased the expression of p62, and HCQ did not induce additional augment of p62 expression."
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"HCQ (50 μM) significantly decreased the beclin-1 ( Fig. 5 a) and increased the p62 levels ( Fig. 5 b) and the LC3-II/LC3-I ratio ( Fig. 5 c)."
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"However, the accumulation of the sensor protein exhibited contrasting results, with HCQ increasing the expression of p62 while SHK has no significant change compared with the control group ( Fig.S1B a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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