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Statements

Rosiglitazone inhibits ACE2. 9 / 9
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"In contrast, rosiglitazone treatment significantly attenuated urinary ACE2 activity in db/db mice."
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"However, in type 2 diabetic mice, rosiglitazone normalized hyperglycemia, attenuated renal injury, and decreased urinary ACE2 excretion and renal ADAM17 protein expression but, unlike insulin, did not affect renal ACE2 expression."
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"Rosiglitazone Treatment of Type 2 Diabetic db/db Mice Attenuates Urinary Albumin and Angiotensin Converting Enzyme 2 Excretion.Alterations within the renal renin angiotensin system play a pivotal role in the development and progression of cardiovascular and renal disease."
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"Rosiglitazone treatment decreased urinary ACE2 protein excretion compared to untreated db/db mice."
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"Chronic treatment with rosiglitazone significantly reduced urinary ACE2 activity in treated db/db mice compared to untreated db/db mice (Figure 6a)."
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"Treatment with rosiglitazone attenuated urinary ACE2 protein excretion and activity but had no effect on renal ACE2 in treated db/db mice compared to untreated db/db mice."
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"Rosiglitazone Treatment of Type 2 Diabetic db/db Mice Attenuates Urinary Albumin and Angiotensin Converting Enzyme 2 Excretion."
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"Urinary ACE2 was significantly attenuated by insulin, rosiglitazone and metformin with/without exercise, the agents known to correct high blood glucose concentrations (23-26)."
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"In contrast, rosiglitazone treatment significantly attenuated urinary ACE2 activity in db/db mice."
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