IndraLab

Statements

Hydroxychloroquine inhibits IL6. 52 / 53
| 15 37
reach
"HCQ interferes with the TLR7 and TLR9 signaling pathways, reducing the production of IFNalpha, IL-6, and TNF-alpha [XREF_BIBR]."
29670462
reach
"The use of HCQ and CQ has been reported to reduce the overproduction of IL-1B, IL-6, and Granulocyte-colony stimulating factor (GM-CSF)."
32884603
reach
"These results suggest that HCQ or PRED therapy combined with miR-146a inhibition may be utilized to greatly reduce IL-6 production in SLE."
24121037
eidos
"TNF alpha and IL6 production might be inhibited by HCQ and subsequently blocks the cascade of COVID-19 infection ."
33442168
reach
"In addition, the cytokine IL-6, which has been shown to be inhibited by hydroxychloroquine and chloroquine, can induce B cell maturation and antibody production [42]."
32674481
reach
"Hydroxychloroquine also reduces pro inflammatory cytokines, notably TNF-alpha and IL-6, and decreases insulin resistance."
| PMC
reach
"Selective inhibition of IL-6 by HCQ has been demonstrated in vitro as we11.3 ' Serum IgG levels were also significantly reduced in the HCQ group, which may have been related to the reduction in the IL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8565026
reach
"TLR signaling pathways stimulate cytokine production, and CQ and HCQ have been found to inhibit the production of various cytokines, including IL-6, TNF, and IFN-γ, by mononuclear cells [17]."
| PMC
reach
"HCQ interferes with antigen processing and presentation 14, decreases production of IL-1, IL-6, and TNF-alpha XREF_BIBR, XREF_BIBR, and decreases proliferation and cytotoxicity resulting from allorecognition."
21689773
reach
"Furthermore, considering that the levels of systemic inflammation biomarkers significantly decreased among good responders in our study, it is notable that methotrexate alone or in combination with sulfasalazine reduces circulating levels of IL-6 [XREF_BIBR], and hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production from PBMC [XREF_BIBR]."
26353115
reach
"Our in vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication."
23778483
reach
"This dichotomous effect (inhibition of CD4 T-cell stimulation and promotion of CD8 T-cell stimulation), which still needs to be demonstrated with chronic antimalarial use, may explain in part the paucity of opportunistic infections during antimalarial therapy.In vitro studies have shown that both chloroquine and hydroxychloroquine decrease the production of TNF-α , IL-6, and IFN-γ by mitogen-stimulated peripheral blood lymphocytes (38)."
17970883
reach
"The mechanism is not fully understood, but it is hypothesized that hydroxychloroquine decreases the production of IL-1, IL-6, and TNF-α, which inhibits toll-like receptor (TLR) 3 and 7 and consequently lowers the likelihood of developing SLE-MAS (98)."
34987500
eidos
"In cultured plasmacytoid dendritic cells ( pDC ) and natural killer ( NK ) cells from healthy donors , HCQ blocked TNF-alpha and IL-6 production in pDCs but not in NK cells after stimulation by RNA-containing immune complexes ."
| PMC
reach
"Chloroquine (CQ) and hydroxychloroquine (HCQ) reduce IL-1, IL-6, IFN-alpha and TNFalpha by inhibiting major histocompatibility complex (MHC II), antigen presentation and immune activation."
33278517
eidos
"Hydroxychloroquine inhibits IL-6 , IL1-beta and TNF-alfa release ( Quiros Roldan et al ., 2020 ) , and it showed also anti-thrombotic properties interfering with platelet aggregation and blood clotting proteins ( Quiros Roldan et al ., 2020 ) ."
| PMC
reach
"In peripheral blood mononuclear cells, HCQ could inhibit phytohemagglutinin (PHA)-induced TNF-alpha and IFN-gamma production, and lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 production, but failed to affect PHA induced IL-6 production [29]."
| PMC
eidos
"HCQ has also been implicated in the reduction of other anti-inflammatory cytokines ; in vitro studies have shown that HCQ can reduce the production of IL-1 , IL-6 , TNF , INFgamma by mononuclear cells , and reduce TNF , INF , IL-6 , and CCL4 in plasmacytoid dendritic cells ( pDC , an immune cell type linked to viral defense ) and natural killer cell co-cultures ( Wallace et al ., 1993 ; Wallace et al ., 1994 ) ."
34122106
reach
"In pDC cultures and pDC/NK cocultures, both I92 and HCQ blocked IL-6, IL-8, and MIP1-α, whereas I92 also blocked IFN-γ and MIP1-β production."
30355354
reach
"Hydroxychloroquine inhibited production of IL-1-alpha (monocytes) and IL-6 (T cells and monocytes)."
8336306
eidos
"Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
reach
"It is reported that hydroxychloroquine may reduce TNF, interleukin-1 and interleukin-6 production though the consistency and mechanisms of this effect are uncertain."
30702995
eidos
"Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
reach
"In cultured plasmacytoid dendritic cells (pDC) and natural killer (NK) cells from healthy donors, HCQ blocked TNF-alpha and IL-6 production in pDCs but not in NK cells after stimulation by RNA containing immune complexes."
| PMC
reach
"In addition, hydroxychloroquine has been demonstrated to exhibit anti-inflammatory activity and can significantly decrease the IL-1, IL-6, TNF-alpha and TNF production through Toll like receptor and NF-kappaB signalling (99, 100)."
33236131
reach
"In vitro studies have shown that HCQ decreases the production of TNF-α, IL-6 and IFN-α by mitogen-stimulated peripheral blood lymphocytes [12]."
25348033
reach
"Consistent with its immunomodulator property, hydroxychloroquine also reduces pro-inflammatory cytokines, notably TNFα and IL6, thereby decreasing insulin resistance."
32283128
eidos
"Contrarily , CQ and HCQ inhibited IL-1 , IL-2 , IL-6 , IL-17 , and IL-22 as well as PGs ( Table 1 ) Tumor necrosis factor ( TNF ) is a pleiotropic cytokine that partakes in crucial regulatory roles in immune and inflammatory responses via cell surface receptors [ 59 , 101 ] ."
33062720
reach
"IL-6 plays a central role in the COVID- 19 Cytokine storm ( An extra figure to illustrate this point would be needed)With in the domain of therapeutic implications, some subheadings can go like ' IL-6 inhibitors'Steroids Hydroxychloroquine, azithromycin 4."
32539627
reach
"CONCLUSIONS Our in vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication."
23778483
eidos
"Chloroquine and hydroxychloroquine Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
eidos
"The patient was started on hydroxychloroquine , which suppresses interleukin-6 and tumor necrosis factor-alpha , which can lead to control of the cytokine storm [ 9 ] ."
33451758
eidos
"In addition , hydroxychloroquine has a modulating effect on activated immune cells , downregulates the expression of Toll-like receptors ( TLRs ) and TLR-mediated signal transduction , and decreases the production of interleukin-6 [ 6 ] ."
32194152
reach
"Another study showed that HCQ inhibited production of IL-1alpha (monocytes) and IL-6 (T cells and monocytes), whereas failed to affect the productions of IL-2, IL-4, TNF-alpha and IFN-gamma [30]."
| PMC
eidos
"For patients with IL-6 levels lower than 60 pg mL -1 before treated with HCQ , HCQ decreased IL-6 levels from 12.8 ( 8.2-23.5 ) pg mL -1 to 3.5 ( 2.7-5.6 ) pg mL -1 after 5 days , and reached 3.0 ( 2 ."
32418114
reach
"Hydroxychloroquine reduces IL-6 and pro thrombotic status."
32413408
reach
"Thus, HCQ therapy inhibits the production of tumor necrosis factor-alpha (TNF-alpha), IL-1, and IL-6 by mononuclear cells [24,27]."
34779707
reach
"We previously demonstrated that HCQ inhibits the production of IL-1-a and IL-6 in vitro by inhibiting posttranscriptional modification. ""
8565026
reach
"Hydroxychloroquine also has immunomodulatory effects, and has been reported to decrease IL-1, IL-2, IL-6, IL-17, IL-22, IFN-alpha, and tumor necrosis factor [XREF_BIBR, XREF_BIBR]."
| PMC
eidos
"Chloroquine and hydroxychloroquine Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
reach
"CQ and HCQ may inhibit the release of IL-6, IL-1B, and TNF-a and so cause a decrease in hepcidin and inhibit viral replication [32]."
32901413
reach
"Furthermore, chloroquine and hydroxychloroquine have well-known immunomodulatory effects, suppressing the production/release of TNF-α and IL-6, thus modulating the host hyperimmune response."
32472459
eidos
"The exact mechanism via which HCQ decreased IL-6 and IL-17 as well as IL-22 concentrations is still a matter of debate ."
33062720
reach
"Hydroxychloroquine also inhibited CpG induced production of interleukin-6 and tumor necrosis factor-alpha in B cell subsets."
29981383
reach
"The mechanism is not fully understood, but it is hypothesized that hydroxychloroquine decreases the production of IL-1, IL-6, and TNF-a, which inhibits toll-like receptor (TLR) 3 and 7 and consequently lowers the likelihood of developing SLE-MAS (98) ."
34987500
eidos
"Differential suppression of NF-kappaB activation , TNF-alpha , and IL-6 by HCQ and QC could also affect antimalarial response in CLE patients ."
30227141
reach
"In two clinical trials conducted in the 1990s, Sperber et al. reported suppressive effects on immune activation (measured at that time as IL-6 production) and viral load in individuals treated with 800mg of hydroxychloroquine and day (bioequivalent to 500mg/day of chloroquine) [XREF_BIBR, XREF_BIBR]."
26084487
eidos
"Contrarily , CQ and HCQ inhibited IL-1 , IL-2 , IL-6 , IL-17 , and IL-22 as well as PGs ( Table 1 ) [ 61 , 98 , 99 ] ."
33062720
reach
"This disrupts antigen processing and inhibiting toll like receptor (TLR) 3, 7, 8, and 9 activity [XREF_BIBR - XREF_BIBR]; furthermore, HCQ can inhibit macrophage production of interleukin-1 and interleukin-6 [XREF_BIBR]."
24460726
reach
"Furthermore, IL-6, IFN-γ, MIP1-α, and MIP1-β production was inhibited by I92, whereas only IL-6 and MIP1-β were significantly inhibited by HCQ (Fig. 4a, b)."
30355354
reach
"In addition, hydroxychloroquine has been demonstrated to exhibit anti-inflammatory activity and can significantly decrease the IL-1, IL-6, TNF-alpha and TNF production through Toll like receptor and NF-kappaB signalling."
33236131
reach
"Hydroxychloroquine inhibits IL-6, IL1-beta and TNF-alfa release, and it showed also anti-thrombotic properties interfering with platelet aggregation and blood clotting proteins."
| PMC