IndraLab

Statements

Hydroxychloroquine inhibits PPT1. 8 / 8
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eidos
"Ppt1 inhibition by HCQ , or DC661 , induced cyclic GMP-AMP synthase ( cGAS ) , stimulator of interferon genes ( STING ) , tank-binding kinase 1 ( TBK1 ) pathway activation and the secretion of interferon beta ( IFN-beta ) in macrophages which was a key component for augmented T cell-mediated cytotoxicity ."
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"Interestingly, PPT1 inhibition by HCQ or DC661 also led to an increased effect of anti-PD-1 therapy in melanoma in vitro and in a murine in vivo model [133], echoing findings recently made in pancreatic cancer [50]."
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"PPT1 has been found to be upregulated in RA synovial tissue and is inhibited by HCQ in vitro ( Rebecca et al ., 2019 ) ."
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No evidence text available
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"PPT1 inhibition by HCQ- or DC661-treated M2 macrophages produced a significant increase in secreted IFN-β secretion compared with vehicle control (Figure 6B)."
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eidos
"Interestingly , HCQ was introduced by other study to inhibit PPT1 activity 24 ."
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"HCQ and Lys05 also bound to and inhibited PPT1 activity, but only DC661 maintained activity in acidic media."
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"While the combination of anti–PD-1 and PPT1 inhibition by HCQ did not result in significant change in the number of activated T cells as assessed by immunophenotyping, the clear changes in macrophage populations could also have a significant impact on antitumor activity."
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