IndraLab
Statements
Hydroxychloroquine inhibits Kv11.1. 4 / 4
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4
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"HCQ is known to block Kv11.1 (HERG) and induce prolong QT, thus predisposing the patient to malignant arrhythmia such as torsade de points.70, 71 However, studies have found that these arrhythmic toxicities are mostly encountered in chronic use with multiple concomitant QT prolonging agents, metabolic abnormalities, renal insufficiency, as well as medication overdose.72, 73 Because the use of HCQ in COVID-19 has relatively short duration, the risk of developing significant arrhythmia is relatively low."