IndraLab

Statements

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"After internalization, Co‐Fc in CM@Co‐Fc@HCQ catalyzes the generation of a large number of ROS through the Fenton reaction, while HCQ inhibits the fusion of autophagosomes with lysosomes, reducing the clearance of ROS by tumor cells."
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"ROS reduction by HCQ inhibits DXM-induced osteoclastogenesis."
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"In addition, HCQ inhibited growth of cholangiocarcinoma cell line xenograft tumors.Conclusion: HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition, which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment."
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"HCQ, on the other hand, inhibits ROS production and improves NO levels while improving endothelial dysfunction associated with diseases such as diabetes and hypertension [50]."
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"An in vitro study showed that HCQ reduced ROS production through sigma-1 receptors [51]."
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"Before light exposure, HCQ disrupts lysosomal function to inhibit mitophagy, leading to increased ROS and oxidative stress."
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"N-acetyl-l-cysteine, but not hydroxychloroquine, also attenuated ROS production."
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"For instance, in high-glucose conditions, HCQ decreased ROS production in endothelial cells but also diminished NO production and angiogenesis (Rezabakhsh et al., 2017)."
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"Notably, HCQ treatment reversed LPS-induced upregulation of MDA and cytoplasmic ROS and downregulation of GSH and GPx in monocytes, which had some implications for ferroptosis (80)."
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"Furthermore, we found that HCQ inhibited the production of inflammatory cytokines and ROS in response to toll like receptor 4 (TLR4) activation in macrophages."
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"7: Effects of forsythoside A, forsythoside E, chlorogenic acid, and hydroxychloroquine on AGEs induced EA.hy926 Cellular ROS inhibition of cells."
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"Meanwhile, we found that apoptosis of MDSCs was induced in lupus mice by HCQ treatment, and HCQ decreased production of ROS in MDSCs from lupus mice [27] ."
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"Intriguingly, hydroxychloroquine inhibits the production of ROS by affecting the function of polymorphonuclear cells at therapeutic concentration, but has the ability to scavenge at higher concentration [3]."
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"The physiological significance of these results to CQ / HCQ treatment of COVID-19 is not clear but suggests that under some circumstances , HCQ can act to prevent ROS - induced inflammation ."
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"Next, we determined the production of lipid peroxide and ROS in hFob1.19 cells treated with HCQ and found that HG-induced lipid peroxide and ROS accumulation were significantly inhibited by HCQ treatment (Fig. 6F–I)."
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"Further investigation revealed that exposure to HCQ dysregulates Nrf2 activity, a master regulator of neutralizing ROS [162] and consequently, accumulation of DNA damage [163] ."
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"HCQ was shown to inhibit ROS production in activated macrophages [27]."
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