IndraLab

Statements



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"This effect was specific to the H2-receptor blocking activity of these drugs : equivalent degrees of receptor blockade by four different H2 antihistamines resulted in equipotent enhancement; H1-receptor antagonists did not alter histamine release; and aminoguanidine and amodiaquine, agents that inhibit histamine metabolism but do not block H2 receptors, did not enhance histamine release."

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"The earlier study demonstrated that the in vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs ( Barth et al., 1975 )."

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"Also, the same dose of amodiaquine enhanced histamine-stimulated gastric secretion in dogs ( Barth et al., 1975 )."